Fabio Perrotta, Vito D'Agnano, Domenica Francesca Mariniello, Giuseppe Castaldo, Maria Vitale, Mario Cazzola, Andrea Bianco, Filippo Scialò
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a debilitating and progressive lung disease of unknown aetiology, characterized by the relentless deposition of fibrotic tissue. Biomarkers may play a pivotal role as indicators of disease presence, progression, and treatment response. Sirtuins, a family of enzymes with ADP ribosyltransferase or deacetylase activity, have been implicated in several diseases, including pulmonary fibrosis. METHODS: A cross-sectional, prospective, observational single-center study was conducted to investigate the potential role of serum SIRTs levels as biomarkers in patients with IPF...
April 27, 2024: Respiratory Research