Richard W Chapman, Michel R Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, Adam J Plaunt, Donna M Konicek, Vladimir Malinin, Zhili Li, David Cipolla, Walter Perkins
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in TRE- and TP-induced cough, using a dry powder formulation of TP (TPIP) to supplement previous data obtained with an aqueous suspension formulation of TP (TPIS). Experiments in guinea pigs and rats investigated the prostanoid receptor subtype producing cough and whether it involved activation of sensory nerves in the airways and vasculature...
January 2021: ERJ Open Research