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https://www.readbyqxmd.com/read/29444516/cardiac-magnetic-resonance-imaging-of-the-myocardium-in-chronic-kidney-disease
#1
Eva Kis, Laszlo Ablonczy, György S Reusz
Early stages of chronic kidney disease (CKD) are often underdiagnosed, while their deleterious effects on the cardiovascular (CV) system are already at work. Thus, the assessment of early CV damage is of crucial importance in preventing major CV events. Myocardial fibrosis is one of the major consequences of progressive CKD, as it may lead to reentry arrhythmias and long-term myocardial dysfunction predisposing to sudden death and/or congestive heart failure. Subclinical myocardial fibrosis, with a potential key role in the development of uraemic cardiac disease, can be measured and characterised by appropriate cardiac magnetic resonance (CMR) techniques...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29444151/predicting-1-year-mortality-after-hospitalization-for-community-acquired-pneumonia
#2
Ane Uranga, Jose M Quintana, Urko Aguirre, Amaia Artaraz, Rosa Diez, Silvia Pascual, Aitor Ballaz, Pedro P España
BACKGROUND: Community-acquired pneumonia (CAP) is a major public health problem with high short- and long-term mortality. The main aim of this study was to develop and validate a specific prognostic index for one-year mortality in patients admitted for CAP. METHODS: This was an observational, prospective study of adults aged ≥18 years admitted to Galdakao-Usansolo Hospital (Bizkaia, Spain) from January 2001 to July 2009 with a diagnosis of CAP surviving the first 15 days...
2018: PloS One
https://www.readbyqxmd.com/read/29441746/long-term-prognosis-and-clinical-characteristics-of-patients-with-newly-diagnosed-diabetes-mellitus-detected-after-first-acute-myocardial-infarction-from-kamir-nih-registry
#3
Hyun Woong Park, Min Gyu Kang, Kyehwan Kim, Jin Sin Koh, Jeong Rang Park, Young Hoon Jeong, Jong Hwa Ahn, Jeong Yoon Jang, Choong Hwan Kwak, Yongwhi Park, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim, Jin Yong Hwang
BACKGROUND AND OBJECTIVES: After the first acute myocardial infarction (AMI), a considerable proportion of patients are newly diagnosed with diabetes mellitus (DM). However, in AMI, controversy remains regarding the disparity in prognosis between previously diagnosed DM (known-DM) and newly diagnosed DM (new-DM). METHODS: The study included 10,455 patients with AMI (non-DM, 6,236; new-DM, 659; known-DM, 3,560) admitted to one of 15 participating centers in Korea between November 2011 and January 2016 (average follow-up, 523 days)...
February 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29438790/cervical-spinal-fusion-16-year-trends-in-epidemiology-indications-and-in-hospital-outcomes-by-surgical-approach
#4
Stephan N Salzmann, Peter B Derman, Lukas P Lampe, Janina Kueper, Ting Jung Pan, Jingyan Yang, Jennifer Shue, Federico P Girardi, Stephen Lyman, Alexander P Hughes
BACKGROUND: The rate of cervical spinal fusion has been increasing significantly. However, there is paucity of literature describing trends based on surgical approach using complete population databases. We investigated the approach-based trends in epidemiology, indications and in-hospital outcomes of cervical spinal fusion. METHODS: New York's Statewide Planning and Research Cooperative System database was queried to identify patients who underwent primary subaxial cervical fusion from 1997-2012...
February 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29437221/the-complexity-of-determining-whether-a-nursing-home-transfer-is-avoidable-at-time-of-transfer
#5
Kathleen T Unroe, Jennifer L Carnahan, Susan E Hickman, Greg A Sachs, Zachary Hass, Greg Arling
OBJECTIVES: To describe the relationship between nursing facility resident risk conditions and signs and symptoms at time of acute transfer and diagnosis of conditions associated with potentially avoidable acute transfers (pneumonia, urinary tract infection, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) or asthma, dehydration, pressure sores). DESIGN: As part of a demonstration project to reduce potentially avoidable hospital transfers, Optimizing Patient Transfers, Impacting Medical Quality, Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project clinical staff collected data on residents who transferred to the emergency department (ED) or hospital...
February 13, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29437026/vasopressin-in-heart-failure
#6
Michele Iovino, Massimo Iacoviello, Giovanni De Pergola, Brunella Licchelli, Emanuela Iovino, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani
The nonapeptide hormone vasopressin (VP), synthesized by the hypothalamic supraoptic and paraventricular nuclei, exerts important effects on cardiovascular system via its receptors V1, V2 and V3. Patients with congestive heart failure (CHF) present elevated plasma VP levels that induce vasoconstriction, left ventricular hypertrophy, and free water reabsorption that leads to edema and hyponatremia, markers of advanced CHF. Vaptans, antagonists of VP receptors, are able to increase urine output and plasma sodium levels without the increased risk of arrhythmic death induced by diuretics, even though, further studies are needed to establish a possible role of these drugs in the treatment of CHF...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29434130/a-case-of-quetiapine-related-acute-kidney-injury-requiring-transient-continuous-hemodiafiltration
#7
Haruhi Yamada, Yukiko Katsumori, Miki Kawano, Shumpei Mori, Ryo Takeshige, Jun Mukai, Hiroshi Imada, Hiroyuki Shimoura, Hachidai Takahashi, Tadasu Horai, Yutaka Okita, Ken-Ichi Hirata
A 73-year-old man, with congestive heart failure due to combined valvar disease, underwent curative surgery. Although the surgery was successful, his clinical course was eventful because of pulmonary complications, and he began to deteriorate mentally. Quetiapine was prescribed, which appeared to effectively settle his mental status. Following the administration of quetiapine, however, he developed acute kidney injury (AKI) that required continuous hemodiafiltration. Subsequent to discontinuation of quetiapine, his renal function gradually improved...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29433525/assessment-of-clinical-effect-and-treatment-quality-of-immediate-release-carvedilol-ir-versus-slow-release-carvedilol-sr-in-heart-failure-patients-slow-hf-study-protocol-for-a-randomized-controlled-trial
#8
Dong-Ju Choi, Chan Soon Park, Jin Joo Park, Hae-Young Lee, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Seok Keun Hong, Joon-Han Shin, Myung-A Kim, Dae-Gyun Park, Eung-Ju Kim, Soon-Jun Hong, Seok Yeon Kim, Jae-Joong Kim
BACKGROUND: Carvedilol is a non-selective, third-generation beta-blocker and is one of the cornerstones for treatment for patients with heart failure and reduced ejection fraction (HFrEF). However, due to its short half-life, immediate-release carvedilol (IR) needs to be prescribed twice a day. Recently, slow-release carvedilol (SR) has been developed. The aim of this study is to evaluate whether carvedilol-SR is non-inferior to standard carvedilol-IR in terms of its clinical efficacy in patients with HFrEF...
February 13, 2018: Trials
https://www.readbyqxmd.com/read/29432704/clinicopathological-features-and-comorbidities-of-cats-with-mild-moderate-or-severe-hyperthyroidism-a-radioiodine-referral-population
#9
Natalie Watson, Jane K Murray, Sonja Fonfara, Angie Hibbert
Objectives This study sought to explore the clinicopathological features and comorbidities of cats with mild, moderate and severe hyperthyroidism in a radioiodine referral population. Methods Medical records were reviewed, along with results of serum biochemistry, urinalysis, systolic blood pressure and diagnostic imaging performed at the time of radioiodine referral. Cats were grouped by total thyroxine (TT4) levels as mildly (TT4 60.1-124.9 nmol/l), moderately (TT4 125-250 nmol/l) or severely (TT4 >250 nmol/l) hyperthyroid at the time of diagnosis and referral...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29432453/clinical-findings-and-prognosis-of-patients-hospitalized-for-acute-decompensated-heart-failure-analysis-of-the-influence-of-chagas-etiology-and-ventricular-function
#10
Caíque Bueno Terhoch, Henry Fukuda Moreira, Silvia Moreira Ayub-Ferreira, Germano Emilio Conceição-Souza, Vera Maria Cury Salemi, Paulo Roberto Chizzola, Mucio Tavares Oliveira, Silvia Helena Gelas Lage, Edimar Alcides Bocchi, Victor Sarli Issa
AIMS: Explore the association between clinical findings and prognosis in patients with acute decompensated heart failure (ADHF) and analyze the influence of etiology on clinical presentation and prognosis. METHODS AND RESULTS: Prospective cohort of 500 patients admitted with ADHF from Aug/2013-Feb/2016; patients were predominantly male (61.8%), median age was 58 (IQ25-75% 47-66 years); etiology was dilated cardiomyopathy in 141 (28.2%), ischemic heart disease in 137 (27...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29428540/in-vitro-assessment-of-the-interactions-of-dopamine-%C3%AE-hydroxylase-inhibitors-with-human-p-glycoprotein-and-breast-cancer-resistance-protein
#11
Joana Bicker, Gilberto Alves, Ana Fortuna, Patrício Soares-da-Silva, Amílcar Falcão
Inhibition of the biosynthesis of noradrenaline is a currently explored strategy for the treatment of hypertension, congestive heart failure and pulmonary arterial hypertension. While some dopamine β-hydroxylase (DBH) inhibitors cross the blood-brain barrier (BBB) and cause central as well as peripheral effects (nepicastat), others have limited access to the brain (etamicastat, zamicastat). In this context, peripheral selectivity is clinically advantageous, in order to prevent alterations of noradrenaline levels in the CNS and the occurrence of adverse central effects...
February 8, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29427301/prospective-validation-and-refinement-of-a-decision-rule-to-obtain-cxr-in-patients-with-non-traumatic-chest-pain-in-the-ed
#12
Case Newsom, Rebecca Jeanmonod, Wendy Woolley, Nirali Shah, Shellie Asher, Eric Bruno, Michael Silberman, Mark Reiter, Donald Jeanmonod
OBJECTIVES: To prospectively validate and refine previously published criteria to determine the potential utility of chest x-ray (CXR) in the evaluation and management of patients presenting to the emergency department (ED) with non-traumatic chest pain. METHODS: A prospective observational study was performed of patients presenting to three EDs in the US with a chief complaint of non-traumatic chest pain. Previously defined high-risk history and exam elements were combined into a refined decision rule and these elements were recorded for each patient by the ED physician...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29426315/effects-of-smoke-free-air-law-on-acute-myocardial-infarction-hospitalization-in-indianapolis-and-marion-county-indiana
#13
Anne M Weaver, Yi Wang, Katelin Rupp, Dennis P Watson
BACKGROUND: A comprehensive smoke-free air law was enacted on June 1, 2012 in most of Marion County, Indiana, including all of the City of Indianapolis. We evaluated changes in acute myocardial infarction (AMI) admission rates in Indianapolis and Marion County before compared to after the law. METHODS: We collected AMI admissions from five Marion County hospitals between May 2007 and December 2014. We used Poisson regression to evaluate the overall effects of the law on monthly AMI hospitalizations, adjusting for month, seasonality, meteorology, air pollution, and hospital utilization...
February 9, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29425051/carbohydrate-antigen-125-a-promising-tool-for-risk-stratification-in-heart-diseases
#14
Felipe Falcão, Flávio R A de Oliveira, Flávio R A de Oliveira, Maria Cleide F C da Silva, Dário C Sobral Filho
All patients with heart diseases should undergo risk stratification to predict those who are at high risk for short- and long-term adverse outcomes. Carbohydrate antigen 125 (CA125) is a glycoprotein produced by mesothelium that has clinical role in ovarian cancer monitoring. However, as it is not specific for ovarian cells, CA125 could also be used in heart diseases to monitor congestion and inflammation. Pericarditis, atrial fibrillation, heart failure and coronary artery disease are some scenarios in which this biomarker was studied...
February 9, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29421933/predictors-for-choledocholitiasis-in-patients-undergoing-endoscopic-ultrasound
#15
Julie Vaynshtein, Gilbert Sabbag, Ilya Pinsk, Ilan Rahmani, Avraham Reshef
AIM: Biliary lithiasis is common in most western countries. Symptomatic patients will also have choledocholithiasis in 10% of the cases. For patients with intermediate probability of CBD stones, the recommended imaging studies are endoscopic ultrasound (EUS) or MRCP. This study aims to identify early factors that can be used as predictors for the presence of CBD stones, and by that to find which patient should undergo ERCP without an early EUS. METHODS: This is a retrospective cohort study including all patients who underwent EUS for suspected choledocholithiasis at the Soroka University Medical Center (SUMC) in the years 2009-2014...
February 8, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29421236/mitoq-improves-mitochondrial-dysfunction-in-heart-failure-induced-by-pressure-overload
#16
Rogério Faustino Ribeiro Junior, Erinne Rose Dabkowski, Kadambari Chandra Shekar, Kelly A O Connell, Peter A Hecker, Michael P Murphy
Heart failure remains a major public-health problem with an increase in the number of patients worsening from this disease. Despite current medical therapy, the condition still has a poor prognosis. Heart failure is complex but mitochondrial dysfunction seems to be an important target to improve cardiac function directly. Our goal was to analyze the effects of MitoQ (100 µM in drinking water) on the development and progression of heart failure induced by pressure overload after 14 weeks. The main findings are that pressure overload-induced heart failure in rats decreased cardiac function in vivo that was not altered by MitoQ...
February 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29420093/the-effects-of-fasting-on-heart-rate-variability-in-hypertensive-patients
#17
Khadija Mzoughi, Ihsen Zairi, Mariem Jabeur, Sondos Kraiem
Heart rate variability (HRV) is an independent indicator of increased mortality in patients with myocardial infarction and congestive heart failure. The effects of fasting on the HRV are not known in hypertensive patients. Therefore, studying the effects of Ramadan fasting on hypertensive patients' HRV seems reasonable to address. We conducted a prospective study including 20 hypertensive patients with sinus rhythm. HRV was determined twice by ambulatory 24-hour Holter recordings at fasting during and after Ramadan...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29419562/acupuncture-and-cardiovascular-disease-focus-on-heart-failure
#18
Yu-Ming Ni, William H Frishman
Symptomatic heart failure is managed with interdisciplinary approaches to reduce acute exacerbations and to improve mortality. Acupuncture is a standardized treatment of Traditional Chinese Medicine that has been shown to have beneficial effects on the cardiovascular system via a neurohumoral pathway known as the long-loop pathway. This article serves to examine recent evidence supporting the long-loop pathway as the physiologic mechanism of acupuncture and the sympatholytic, vasodilatory, and cardioprotective effects of acupuncture that could specifically improve cardiac function and quality of life measures in the management of congestive heart failure...
March 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29419560/implications-of-the-new-national-guidelines-for-hypertension
#19
Wilbert S Aronow, William H Frishman
Automated validated devices should be used for measuring blood pressure (BP). A systolic BP between 120 and 129 mm Hg with a diastolic BP < 80 mm Hg should be treated by lifestyle measures. Lifestyle measures plus BP lowering drugs should be used for secondary prevention of recurrent cardiovascular disease (CVD) events in persons with clinical CVD (coronary heart disease, congestive heart failure, and stroke) and an average systolic BP of ≥130 mm Hg or an average diastolic BP ≥ 80 mm Hg. Lifestyle measures plus BP lowering drugs should be used for primary prevention of CVD in persons with an estimated 10-year risk of atherosclerotic CVD ≥ 10% and an average systolic BP ≥130 mm Hg or an average diastolic BP ≥ 80 mm Hg...
March 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29417235/the-impact-of-anaemia-transfusion-dependency-comorbidities-and-polypharmacy-in-elderly-patients-with-low-risk-myelodysplastic-syndromes
#20
Roberto Castelli, Riccardo Schiavon, Giorgio Lambertenghi Deliliers
Myelodysplastic syndromes (MDS) are heterogeneous clonal disorders ranging from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukaemia. Comorbid conditions have rarely been systematically studied among patients with MDS. Older age per se has a negative impact on survival of MDS patients, in particular of those with lower risk. However, age indirectly affects also the survival of higher-risk patients by limiting their eligibility to intensive treatments. In addition, ageing is associated with an increasingly high risk of developing comorbidity, and a high prevalence of comorbid diseases has indeed been reported in MDS patients...
February 8, 2018: Medical Oncology
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