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Ovarian cryopreservation

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https://www.readbyqxmd.com/read/29136154/the-number-of-oocytes-retrieved-during-ivf-a-balance-between-efficacy-and-safety
#1
Åsa Magnusson, Karin Källen, Ann Thurin-Kjellberg, Christina Bergh
STUDY QUESTION: What is the relationship between the number of oocytes collected in fresh IVF treatments and the likelihood of cumulative delivery rate (fresh and frozen) per oocyte aspiration, severe ovarian hyperstimulation syndrome (OHSS) and thromboembolic events? SUMMARY ANSWER: Cumulative delivery rate per aspiration increases up to 20 oocytes retrieved and then evens out while the incidence of severe OHSS increases more rapidly from around 18 oocytes and thromboembolic events, although rare, occurs in particular if 15 or more oocytes are retrieved...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29130738/ethylene-glycol-and-dimethyl-sulfoxide-combination-reduces-cryoinjuries-and-apoptotic-gene-expression-in-vitrified-laying-hen-ovary
#2
Reihane Nateghi, AliReza Alizadeh, Yousef Jafari Ahangari, Rouhollah Fathi, Amir Akhlaghi
Successful cryopreservation of avian gonads is important not only for avian breeding but is also crucial for preservation of species, especially of endangered birds. The aim of this study was to evaluate the effect of vitrification by several cryoprotectants on the ovarian tissues of laying hens. Ovarian tissues were randomly divided into six groups: control (nonvitrified: C), dehydrated using ethylene glycol (EG), dehydrated with propylene glycol (PROH), dehydrated using dimethyl sulfoxide (DMSO), and two combined groups, EG+DMSO and EG+PROH...
November 13, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29127678/allogeneic-matched-related-transplantation-for-%C3%AE-thalassemia-and-sickle-cell-anemia
#3
Françoise Bernaudin, Corinne Pondarré, Claire Galambrun, Isabelle Thuret
Allogeneic hematopoietic stem cell transplantation (HSCT) can cure single gene disorders such as thalassemia and sickle cell anemia (SCA). These non-malignant diseases have in common severe hemolytic anemia and high proliferative bone marrow, requiring frequent transfusions. The risk of rejection is high and graft-vs-host disease is not desirable. Important progress has been made in the management of these diseases, including leukocyte depletion of blood products, and chelation therapy, for both diseases, and erythrocytapheresis and hydroxycarbamide for SCA...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29117320/update-on-fertility-preservation-from-the-barcelona-international-society-for-fertility-preservation-eshre-asrm-2015-expert-meeting-indications-results-and-future-perspectives
#4
Francisca Martinez
STUDY QUESTION: What progress has been made in fertility preservation (FP) over the last decade? SUMMARY ANSWER: FP techniques have been widely adopted over the last decade and therefore the establishment of international registries on their short- and long-term outcomes is strongly recommended. WHAT IS KNOWN ALREADY: FP is a fundamental issue for both males and females whose future fertility may be compromised. Reproductive capacity may be seriously affected by age, different medical conditions and also by treatments, especially those with gonadal toxicity...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29093602/fertility-preservation-in-female-patients-with-breast-cancer-a-current-overview
#5
Veronika Guenther, Ibrahim Alkatout, Wiebe Junkers, Dirk Bauerschlag, Nicolai Maass, Soeren von Otte
Many premenopausal patients who develop breast cancer have not yet completed their family planning, so measures of fertility protection to preserve their fertile potential would be beneficial. Polychemotherapy causes irreversible damage to the ovarian follicles - irrespective of whether in a neoadjuvant or adjuvant setting - and this can sometimes result in permanent infertility. Depending on which cytostatic agents are used and on the age-related ovarian reserve of the woman, gonadotoxic risk must be classified as low, moderate or high...
October 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29061149/a-modified-and-tailored-human-follicle-isolation-procedure-improves-follicle-recovery-and-survival
#6
Maria Costanza Chiti, Marie-Madeleine Dolmans, Maria Hobeika, Alice Cernogoraz, Jacques Donnez, Christiani Andrade Amorim
BACKGROUND: Ovarian tissue cryopreservation followed by transplantation after cancer remission is the most commonly applied fertility restoration approach in very young girls and women who require immediate cancer therapy. However, clinicians strongly advise against reimplantation of one's own ovarian tissue when there is a high risk of recurrence after grafting. For these patients, development of an alternative strategy, namely a transplantable artificial ovary, offers future hope of conceiving...
October 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29050014/a-real-life-analysis-of-reproductive-outcome-after-fertility-preservation-in-female-cancer-patients
#7
Sofie Hulsbosch, Martin Koskas, Carla Tomassetti, Petra De Sutter, Hans Wildiers, Patrick Neven, Thomas D'Hooghe, Frederic Amant
BACKGROUND: Fertility preservation before or during cancer treatment in young women has become an important health issue because of delayed motherhood and improved survival rates. This study evaluates the necessity and the efficacy of fertility preservation, with a focus on actual pregnancy wish and outcome after fertility preservation and cancer treatment. PATIENTS AND METHODS: All consecutive patients who received fertility preservation in 2 university referral centers before or during cancer treatment were included...
October 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29045555/reproductive-potential-and-performance-of-fertility-preservation-strategies-in-brca-mutated-breast-cancer-patients
#8
M Lambertini, O Goldrat, A R Ferreira, J Dechene, H A Azim, J Desir, A Delbaere, M-D t'Kint de Roodenbeke, E de Azambuja, M Ignatiadis, I Demeestere
BackgroundPreclinical evidence suggests a possible negative impact of deleterious BRCA mutations on female fertility. However, limited and rather conflicting clinical data are available. This study assessed the reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients.Patients and MethodsThis was a retrospective analysis of two prospective studies investigating oocyte cryopreservation and ovarian tissue cryopreservation in newly diagnosed early breast cancer patients...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29043522/cryovial-monolayer-vitrification-for-ovarian-tissue-cryopreservation
#9
Hongxia Li, Haixia Cao, Xingping Guo, Huaixiu Wang
The cryopreservation of ovarian tissue has been proved to be effective for fertility preservation. To find a better cryopreservation method, we tested the efficacy of cryovial monolayer vitrification method in comparison with that of needle immersed vitrification (NIV). Ovaries from 10 female kunming mice aged 6-8 weeks were cut into pieces and allocated into group A (cryovial monolayer vitrification method), group B (NIV method) and group C (fresh control). In group A, pieces of ovarian tissue were layered around the inner wall of cryovial as a monolayer; and in group B, pieces of ovarian tissue were pierced with a needle...
October 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29040589/corifollitropin-alfa-followed-by-highly-purified-hmg-versus-recombinant-fsh-in-young-poor-ovarian-responders-a-multicentre-randomized-controlled-clinical-trial
#10
Panagiotis Drakopoulos, Thi Ngoc Lan Vuong, Ngoc Anh Vu Ho, Alberto Vaiarelli, Manh Tuong Ho, Christophe Blockeel, Michel Camus, Anh Tuan Lam, Arne van de Vijver, Peter Humaidan, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher ongoing pregnancy rates compared with daily recombinant FSH (rFSH) in young poor responders? SUMMARY ANSWER: Corifollitropin alfa followed by hp-HMG does not increase ongoing pregnancy rates compared with rFSH in young poor responders, although more supernumerary cryopreserved embryos were obtained with corifollitropin alfa and hp-HMG. WHAT IS KNOWN ALREADY: Poor ovarian response remains one of the main therapeutic challenges in women undergoing ovarian stimulation, given that very low live birth rates of 6% have been reported in this particular group of infertile patients...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29039070/the-evaluation-of-xenotransplantation-of-feline-ovarian-tissue-vitrified-by-needle-immersed-vitrification-technique-into-male-immunodeficient-mice
#11
Mürşide Ayşe Demirel, Duygu Baki Acar, Burcu Ekim, Ferda Topal Çelikkan, Kübra Karakaş Alkan, Seçkin Salar, Esra Atabenli Erdemli, Sinan Özkavukçu, Seda Sağlam Yar, Halit Kanca, Ayhan Baştan
In this study, the efficiency of the "Needle Immersed Vitrification" technique was tested on cryopreserved feline ovarian tissue. For vitrification, ovarian fragments (0.5-1.5 mm(2)) from each ovary were collected; the grafts were exposed to 7.5-15% ethylene glycol and 7.5-15% dimethyl sulfoxide at room temperature and stored in liquid nitrogen at least 1 week. Morphologic examinations, expression of genes such as B cell lymphoma 2, B-cell lymphoma-2-associated X protein, Bone morphogenetic protein 15, zone of polarizing activity, zona pellucida C protein and DNA (cytosine-5)-methyltransferase 1, ultrastructural analysis and viability tests were carried out from collected grafts...
October 16, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29032255/single-incision-laparoscopic-surgery-sils-for-ovarian-tissue-cryopreservation
#12
Gilad Karavani, Natali Schachter-Safrai, Henry H Chill, Talya Mordechai Daniel, Dvora Bauman, Ariel Revel
STUDY OBJECTIVE: To present single-incision laparoscopic surgery (SILS) as an alternative to standard multi-port laparoscopic surgery (MPLS) for ovarian tissue cryopreservation (OTC). DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Tertiary medical center. PATIENTS: Two hundred thirty-one patients referred for oncological fertility preservation. INTERVENTION: Non-inferiority comparison of SILS to MPLS for ovarian cryopreservation for future transplantation...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29030068/double-ovarian-stimulation-during-the-follicular-and-luteal-phase-in-women-%C3%A2-38-years-a-retrospective-case-control-study
#13
Conghui Liu, Hong Jiang, Wenxiang Zhang, Huiqun Yin
Previous studies have shown that double ovarian stimulation could obtain more oocytes in women with poor ovarian response. This retrospective case-control study aimed to investigate the efficacy of double ovarian stimulation in older women. One hundred and sixteen women aged ≥38 years who received double ovarian stimulation were assigned to the study, with 103 divided into four groups according to follicular-phase ovarian stimulation protocols, including gonadotrophin-releasing hormone agonist short protocol (n = 27), gonadotrophin-releasing hormone antagonist protocol (n = 32), mild stimulation protocol (n = 21) and medrocyprogesterone acetate (MPA) pituitary down-regulation protocol (n = 23)...
August 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28987775/slow-freezing-versus-vitrification-technique-for-human-ovarian-tissue-cryopreservation-an-evaluation-of-histological-changes-wnt-signaling-pathway-and-apoptotic-genes-expression
#14
Azam Dalman, Nafiseh Sadat Deheshkar Gooneh Farahani, Mehdi Totonchi, Reihaneh Pirjani, Bita Ebrahimi, Mojtaba Rezazadeh Valojerdi
This study compared slow freezing and vitrification of ovarian tissue by evaluation of histological changes, WNT signaling pathway and apoptotic genes expression. Ovarian tissue was obtained from women aging 27-38 years old. Ovarian cortex from each patient was divided into three pieces and randomly grouped as slow freezing, vitrification and control groups for investigation of WNT signaling gene expression and β-CATENIN presence as well as histological studies. The stromal structure of all ovaries were preserved...
October 4, 2017: Cryobiology
https://www.readbyqxmd.com/read/28986734/antral-follicle-responsiveness-to-fsh-assessed-by-the-follicular-output-rate-fort-is-altered-in-hodgkin-s-lymphoma-when-compared-with-breast-cancer-candidates-for-fertility-preservation
#15
Charlotte Sonigo, Marjorie Comtet, Solene Duros, Christophe Sifer, Nathalie Sermondade, Michaël Grynberg
PURPOSE: Oocyte and/or embryo cryopreservation after controlled ovarian hyperstimulation (COH) represents the most established method for female fertility preservation (FP) before cancer treatment. Whether patients suffering from malignancies, candidates for FP, have a normal ovarian capacity to respond to stimulation is controversial. Reduced responsiveness of antral follicle to exogenous FSH might be at play. The percentage of antral follicles that successfully respond to FSH administration may be estimated by the follicular output rate (FORT), which presumably reflects the health of granulosa cells...
October 6, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28973701/fertility-preservation-in-breast-cancer
#16
REVIEW
Cristina O'Donoghue, Gwendolyn P Quinn, M Catherine Lee
As more young women survive breast cancer, fertility preservation (FP) is an important component of care. This review highlights the importance of early pretreatment referral, reviews the risks of infertility associated with breast cancer treatment, and defines existing and emerging techniques for FP. The techniques reviewed include ovarian suppression, embryo cryopreservation, oocyte cryopreservation, and ovarian tissue cryopreservation and transplantation. The barriers women face, such as not being appropriately referred and the costs of treatment, also are addressed...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28967642/comparison-of-various-tissue-and-cell-therapy-approaches-when-restoring-ovarian-hepatic-and-kidney-s-function-after-chemotherapy-induced-ovarian-failure
#17
M M Kozub, V Y Prokopiuk, K P Skibina, O V Prokopiuk, N I Kozub
About 1% of women suffer from premature ovarian failure, which leads to a significant deterioration in the life quality. Most often this condition is caused by performed chemotherapy, autoimmune diseases, surgery performed on ovaries, uterus, or fallopian tubes. The aim of this study was to compare different approaches of tissue and cell therapy in restoring the sexual function in case of ovarian failure induced by chemotherapy. MATERIALS AND METHODS: The study was carried out in BALB/c mice with the modeled ovarian failure, induced by cyclophosphamide and busulfan...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28960429/the-effects-of-low-dose-human-chorionic-gonadotropin-combined-with-human-menopausal-gonadotropin-protocol-on-women-with-hypogonadotropic-hypogonadism-undergoing-ovarian-stimulation-for-in-vitro-fertilization
#18
Shutian Jiang, Yanping Kuang
OBJECTIVES: To investigate the effects of low-dose human chorionic gonadotropin (hCG) combined with human menopausal gonadotropin (HMG) protocol on cycle characteristics and outcomes of infertile women with hypogonadotropic hypogonadism (HH) undergoing ovarian stimulation for in vitro fertilization (IVF). DESIGN: A retrospective cohort study. SETTING: Tertiary-care academic medical centre. PATIENT(S): Forty-six infertile patients with HH and seventy-one infertile patients with tubal factor (TF) infertility undergoing IVF...
September 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28942372/restoration-of-fresh-cat-ovarian-tissue-function-by-autografting-to-subcutaneous-tissue-a-pilot-study
#19
Ellen C R Leonel, Janice M V Vilela, Raísa E G Paiva, José L P R Jivago, Rodrigo S Amaral, Carolina M Lucci
Ovarian tissue transplantation could be a valuable technique for the preservation of endangered animals. The domestic cat affords an adequate experimental model for studies aimed at wild felids due to its phylogenetic similarity. Thus, this pilot study evaluated the efficacy of cat ovarian tissue autotransplantation to a peripheral site. Three adult queens were submitted to ovariohysterectomy. The ovaries were fragmented into eight pieces; two were fixed as a control and six were transplanted to subcutaneous tissue of the dorsal neck...
January 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/28938728/modeling-of-live-birth-rates-and-cost-effectiveness-of-oocyte-cryopreservation-for-cancer-patients-prior-to-high-and-low-risk-gonadotoxic-chemotherapy
#20
B Lyttle Schumacher, N Grover, T Mesen, A Steiner, J Mersereau
STUDY QUESTION: What is the live-birth rate (LBR) and cost-effectiveness of fertility preservation with oocyte cryopreservation (FP-OC) compared to expectant management in cancer patients age 25-40 based on estimated gonadotoxicity of treatments 5 years after cancer diagnosis? SUMMARY ANSWER: Oocyte cryopreservation prior to cancer treatment is more costly, yet more effective (producing more live births), than not undergoing oocyte cryopreservation but it is most beneficial for patients undergoing high-risk chemotherapy (HRC)...
October 1, 2017: Human Reproduction
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