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Susanna Sforzini, Caterina Oliveri, Andrea Orrù, Giannina Chessa, Beniamina Pacchioni, Caterina Millino, Awadhesh N Jha, Aldo Viarengo, Mohamed Banni
In the present study, we investigated the health status of marine mussels (Mytilus galloprovincialis) caged and deployed at three different sites on the Sardinian coastline characterized by different levels of contamination: Fornelli (F, the reference site), Cala Real (CR), and Porto Torres (PT). A new low density oligonucleotide microarray was used to investigate global gene expression in the digestive gland of mussels. Target genes were selected to cover most of the biological processes involved in the stress response in bivalve mollusks (e...
February 11, 2018: Science of the Total Environment
Jian Hou, Huizhen Sun, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Diabetes is related to exposure to polycyclic aromatic hydrocarbons (PAHs), inflammation in the body and housing characters. However, associations of urinary monohydroxy-PAHs (OH-PAHs) or fractional exhaled nitric oxide (FeNO) with diabetes risk in relation to housing characters are unclear. In this study, 2645 individuals were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. Associations of diabetes with urinary OH-PAHs or FeNO among cooking participants were estimated using logistics regression models...
February 14, 2018: Indoor Air
Savita Chaudhary, Priyanka Sharma, Arshpreet Kaur, Rajeev Kumar, S K Mehta
This manuscript represents the synthesis of silica nanoparticles modified with four different types of cationic surfactants. The surfactant capped nanoparticles have better control over the size of silica nanoparticles. The as formed as model nanomaterials were used for the removal of naphthalene, a simple white crystalline polycyclic aromatic hydrocarbon (PAH) from aqueous media. The obtained materials were characterized by various microscopic and spectroscopic techniques. The average particle size of nanoparticles was approximately between 50 and 75 nm...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Antonio Wellington Lima de Sa, Hugo Gajardoni de Lemos, Marcelo A Pereira-da-Silva, Everaldo Carlos Venancio
In this work it was studied the production of nanostructured thin films containing alternating layers of poly(allylamine hydrochloride) (PAH) and bovine serum albumin protein (BSA). It was studied the adsorption processes of these materials onto solid surfaces, which included adsorption kinetics and film growth studies by using UV-Vis spectroscopy. The film morphology, thickness and roughness were studied by using atomic force microscopy (AFM). The AFM results showed that the film presented a globular-like surface morphology and a thickness within the nanoscale, which could be controlled by the number of deposited layers...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Imen Gdara, Ines Zrafi, Catia Balducci, Angelo Cecinato, Ahmed Ghrabi
Polycyclic aromatic hydrocarbons are of great concern due to their persistence, bioaccumulation and toxic properties. The occurrence, source and ecological risk assessment of 26 polycyclic aromatic hydrocarbons in industrial and agricultural effluents affecting the Wadi El Bey watershed were investigated by means of gas chromatographic/mass spectrometric analysis (GC/MS). Total PAHs (∑ 26 PAH) ranged from 1.21 to 91.7 µg/L. The 4- and 5-ring compounds were the principal PAHs detected in most of 5 sites examined...
February 13, 2018: Environmental Geochemistry and Health
Ying Pang, Ming-Ting Liang, Ying Gong, Yong Yang, Pei-Li Bu, Mei Zhang, Heng-Chen Yao
The purpose of the present study was to investigate the anti-inflammatory effect of hepatocyte growth factor (HGF) on pulmonary artery hypertension (PAH) in a rat model and underlying mechanisms. Wistar rats were treated with monocrotaline intravenously to induce PAH and then treated with vehicle or HGF for 2 weeks, respectively. The mean pulmonary artery pressure (mPAP), the index of right heart ventricular hypertrophy (RHVI), pathological changes, and inflammation in the lungs of individual rats were measured...
February 13, 2018: Inflammation
Xing Chen, Xinran Liu, Min Liu, Yi Yang, Shixue Wu, Chong Wang
Spatial-temporal distributions, source identification, and possible effects of land use patterns on PAHs were studied in overlying water and surface sediments in Yangtze estuarine and nearby coastal areas. The concentrations of PAHs ranged from 172.6 ± 9.3 to 5603.7 ± 548.7 ng L-1, 841.0 ± 36.6 to 31 190.5 ± 3711.5 ng g-1and 312.3 ± 7.6 to 9081.1 ± 862.3 ng g-1, with mean contents of 1042.9 ng L-1, 8922.9 ng g-1and 2400.2 ng g-1in water, suspended particulate matter (SPM) and sediments. PAH concentrations in three phases were higher in dry seasons (January and April) than in rainy seasons (July and October), and showed a distribution pattern as freshwater area > transition area > seawater area...
February 14, 2018: Environmental Science. Processes & Impacts
Shini Feng, Huijie Zhang, Chunyi Zhi, Xiao-Dong Gao, Hideki Nakanishi
Background: Anticancer drug-delivery systems (DDSs) capable of responding to the physiological stimuli and efficiently releasing drugs inside tumor cells are highly desirable for effective cancer therapy. Herein, pH-responsive, charge-reversal poly(allylamine hydrochlorid)-citraconic anhydride (PAH-cit) functionalized boron nitride nanospheres (BNNS) were fabricated and used as a carrier for the delivery and controlled release of doxorubicin (DOX) into cancer cells. Methods: BNNS was synthesized through a chemical vapor deposition method and then functionalized with synthesized charge-reversal PAH-cit polymer...
2018: International Journal of Nanomedicine
Grzegorz Majewski, Kamila Widziewicz, Wioletta Rogula-Kozłowska, Patrycja Rogula-Kopiec, Karolina Kociszewska, Tomasz Rozbicki, Małgorzata Majder-Łopatka, Mariusz Niemczyk
This study assessed inhalation exposure to particulate matter (PM₁)-bound mercury (Hg p ) and PM₁-bound polycyclic aromatic hydrocarbons (PAHs) among university students. For this purpose, simultaneous indoor (I) and outdoor (O) measurements were taken from two Polish technical universities (in Gliwice and Warsaw) located in distinct areas with respect to ambient concentrations and major sources of PM. The indoor geometric mean concentrations of Hg p were found to be 1.46 pg·m -3 and 6.38 pg·m -3 in Warsaw and Gliwice, while the corresponding outdoor concentrations were slightly lower at 1...
February 12, 2018: International Journal of Environmental Research and Public Health
Songyan Zhang, Shuaizhang Li, Zhiguang Zhou, Hualing Fu, Li Xu, Heidi Qunhui Xie, Bin Zhao
Airborne persistent toxic substances are associated with health impacts resulting from air pollution, e.g. dioxins, dioxin-like polychlorinated biphenyls and certain polycyclic aromatic hydrocarbons (PAHs), which activate aryl hydrocarbon receptor (AhR) and thereby produce the adverse outcomes. Thus, a bioassay for evaluating AhR activation is required for the risk assessment of ambient-air samples, and for this purpose, we developed a new and sensitive recombinant mouse hepatoma cell line, CBG2.8D, in which a novel luciferase-reporter plasmid containing 2 copies of a newly designed dioxin-responsive domain and a minimal promoter derived from a native gene were integrated...
February 13, 2018: Environmental Science & Technology
Nika Skoro-Sajer, Christian Gerges, Olga Hajnalka Balint, Dora Kohalmi, Monika Kaldararova, Iveta Simkova, Johannes Jakowitsch, Harald Gabriel, Helmut Baumgartner, Mario Gerges, Roela Sadushi-Kolici, David S Celermajer, Irene Marthe Lang
OBJECTIVE: To assess the efficacy and safety of subcutaneous treprostinil in adult patients with congenital heart disease (CHD)-associated pulmonary arterial hypertension (PAH) after 12 months of treatment. METHODS: Consecutive adult patients with CHD-PAH received subcutaneous treprostinil to maximum tolerated doses in an observational study. RESULTS: Advanced CHD-PAH patients with WHO class III or IV disease (n=32, age 40±10 years, 20 females) received treprostinil for suboptimal response to bosentan (n=12), WHO functional class IV disease (FC, n=7) or prior to bosentan approval (n=13)...
February 7, 2018: Heart: Official Journal of the British Cardiac Society
Charles D Burger, A Burak Ozbay, Howard M Lazarus, Ellen Riehle, Leslie B Montejano, Gregory Lenhart, R James White
BACKGROUND: Despite multiple treatment options, the prognosis of pulmonary arterial hypertension (PAH) remains poor. PAH patients experience a high economic burden due to comorbidities, hospitalizations, and medication costs. Although combination therapy has been shown to reduce hospitalizations, the relationship between treatment, health care utilization, and costs remains unclear. OBJECTIVE: To provide a characterization of health care utilization and costs in real-world settings by comparing periods before and after initiating PAH-specific treatment...
February 13, 2018: Journal of Managed Care & Specialty Pharmacy
Abhishek Kumar, Priyashree Sunita, Shivesh Jha, Shakti P Pattanayak
Breast cancer (BC) is a persistent and impulsive metabolic disorder with the highest prevalence in women, worldwide. 7,12-Dimethylbenz(a)anthracene (DMBA) is a potent polyaromatic hydrocarbon (PAH)-based carcinogen producing mammary carcinomas in rats resembling the human hormone-dependent BC. 7,8-Dihydroxycoumarin (78DC) is a coumarin derivative that possesses diversified and favorable pharmacology profile to be considered in anticancer research against various malignancies. The present study was intended to investigate the antiproliferative and chemotherapeutic potentials of 78DC (20, 40, and 80 mg/kg BW) against DMBA (20 mg in olive oil)-induced mammary carcinoma Sprague-Dawley rats...
February 12, 2018: Journal of Physiology and Biochemistry
Susana Hoette, Nicolas Creuzé, Sven Günther, David Montani, Laurent Savale, Xavier Jaïs, Florence Parent, Olivier Sitbon, Carlos Eduardo Rochitte, Gerald Simonneau, Marc Humbert, Rogerio Souza, Denis Chemla
BACKGROUND: The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the right ventricular fractional area change (RVFAC) takes into account both the longitudinal and the transversal components. The aim of our study was to evaluate the relationship between RVEF, RVFAC, and TAPSE according to hemodynamic severity in two groups of patients with PH: pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH)...
February 12, 2018: Lung
Gisela M B Meyer, Fernanda B Spilimbergo, Stephan Atmayer, Gabriel S Pacini, Matheus Zanon, Guilherme Watte, Edson Marchiori, Bruno Hochhegger
INTRODUCTION: Our goal was to assess the diagnostic performance of magnetic resonance imaging (MRI) as a single method to diagnose pulmonary hypertension (PH) compared to right heart catheterization (RHC), computed tomography (CT), and ventilation/perfusion (V/Q) scintigraphy. METHODS: We identified 35 patients diagnosed with PH by RHC in our institution who have also undergone a CT, a scintigraphy, and an MRI within a month. All cases were discussed in multidisciplinary meetings...
February 12, 2018: Lung
Jing Yu, Shukui Zhu, Liling Pang, Pin Chen, Gang-Tian Zhu
Stable and reusable porphyrin-based magnetic nanocomposites were successfully synthesized for efficient extraction of polycyclic aromatic hydrocarbons (PAHs) from environmental water samples. Meso-Tetra (4-carboxyphenyl) porphyrin (TCPP), a kind of porphyrin, can connect the copolymer after amidation and was linked to Fe3O4@SiO2 magnetic nanospheres via cross-coupling. Several characteristic techniques such as field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, vibrating sample magnetometry and a tensiometer were used to characterize the as-synthesized materials...
February 7, 2018: Journal of Chromatography. A
Oriol Baltrons, Montserrat López-Mesas, Mercè Vilaseca, Carmen Gutiérrez-Bouzán, Franck Le Derf, Florence Portet-Koltalo, Cristina Palet
In order to assess the effect of mixed pollutants, the influence of different concentration levels of a mixture of metals (Cr, Co, Pb, Mn, Ni, Cu, Zn) on the biodegradation of some PAHs (phenanthrene, fluoranthene, pyrene, benzo[b]fluoranthene and benzo[a]pyrene) in soil samples was evaluated. To do so, groups of microcosms of a natural soil from the region of Sabadell (Barcelona, Spain) were prepared as a reproduction of the native environment at laboratory scale, under controlled conditions. Mixtures of PAHs and metals were carefully selected, according to soil characterization and microbiological growth preliminary assays, and were added to microcosms...
February 9, 2018: Science of the Total Environment
Helena Libalova, Pavel Rossner, Kristyna Vrbova, Tana Brzicova, Jitka Sikorova, Michal Vojtisek-Lom, Vit Beranek, Jiri Klema, Miroslav Ciganek, Jiri Neca, Miroslav Machala, Jan Topinka
Modern vehicles equipped with Gasoline Direct Injection (GDI) engine have emerged as an important source of particulate emissions potentially harmful to human health. We collected and characterized gasoline exhaust particles (GEPs) produced by neat gasoline fuel (E0) and its blends with 15% ethanol (E15), 25% n-butanol (n-But25) and 25% isobutanol (i-But25). To study the toxic effects of organic compounds extracted from GEPs, we analyzed gene expression profiles in human lung BEAS-2B cells. Despite the lowest GEP mass, n-But25 extract contained the highest concentration of polycyclic aromatic hydrocarbons (PAHs), while i-But25 extract the lowest...
February 9, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Peter Afdal, Antoine F AbdelMassih
Severe angio-obliterative pulmonary vascular disease (PAH) remains a disease characterized by great morbidity and shortened survival. Unfortunately, the only currently available treatments for angio-obliterative changes are palliative in the form of pulmonary vasodilators evolving from the phosphodiesterase inhibitor sildenafil to endothelin receptor antagonist: Bosentan; while the only definitive treatment is lung transplantation which remains dependent on the availability of donors and the transplant policies which vary widely from a country to another...
February 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Kuang-Hueih Chen, Asish Dasgupta, Jianhui Lin, Francois Potus, Sebastien Bonnet, James Iremonger, Jennifer Fu, Jeffrey Mewburn, Danchen Wu, Kimberly Dunham-Snary, Anne L Theilmann, Zhi-Cheng Jing, Charles Hindmarch, Mark L Ormiston, Allan Lawrie, Stephen L Archer
Background -Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The fission mediator, dynamin related protein 1 (Drp1) must complex with adaptor proteins to cause fission. Drp1-induced fission has been therapeutically targeted in experimental PAH. Here we examine the role of two recently discovered, poorly understood, Drp1 adapter proteins, mitochondrial dynamics protein of 49 and 51 kDa (MiD49 and MiD51) in normal vascular cells and explore their dysregulation in PAH...
February 5, 2018: Circulation
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