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https://www.readbyqxmd.com/read/29684897/reproductive-and-developmental-changes-in-tree-swallows-tachycineta-bicolor-are-influenced-by-multiple-stressors-including-polycyclic-aromatic-compounds-in-the-athabasca-oil-sands
#1
K J Fernie, S C Marteinson, C Soos, D Chen, L Cruz-Martinez, J E G Smits
Mining in the Athabasca Oil Sands Region (AOSR) has contributed extensively to increased exposure of wildlife to naturally occurring polycyclic aromatic compounds (PACs), yet little is known about the toxicity of PACs to wildlife in this region. We identified reproductive and developmental changes in tree swallows (Tachycineta bicolor) breeding in close proximity to mining-related activities in the AOSR, and determined these changes in relation to the birds' exposure and accumulation of 41 PACs (parent-, alkylated-PAHs), dibenzothiophenes (DBTs; previously published), diet (carbon (δ13 C), nitrogen (δ15 N)), volatile organic compounds, and weather variables...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684877/toxicity-and-mutagenicity-of-exhaust-from-compressed-natural-gas-could-this-be-a-clean-solution-for-megacities-with-mixed-traffic-conditions
#2
Avinash K Agarwal, Bushra Ateeq, Tarun Gupta, Akhilendra P Singh, Swaroop K Pandey, Nikhil Sharma, Rashmi A Agarwal, Neeraj K Gupta, Hemant Sharma, Ayush Jain, Pravesh C Shukla
Despite intensive research carried out on particulates, correlation between engine-out particulate emissions and adverse health effects is not well understood yet. Particulate emissions hold enormous significance for mega-cities like Delhi that have immense traffic diversity. Entire public transportation system involving taxis, three-wheelers, and buses has been switched from conventional liquid fuels to compressed natural gas (CNG) in the Mega-city of Delhi. In this study, the particulate characterization was carried out on variety of engines including three diesel engines complying with Euro-II, Euro-III and Euro-IV emission norms, one Euro-II gasoline engine and one Euro-IV CNG engine...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684875/toxicoproteomic-analysis-of-human-lung-epithelial-cells-exposed-to-steel-industry-ambient-particulate-matter-pm-reveals-possible-mechanism-of-pm-related-carcinogenesis
#3
S Senthil Kumar, P Muthuselvam, V Pugalenthi, N Subramanian, K M Ramkumar, T Suresh, T Suzuki, P Rajaguru
Toxicoproteomic analysis of steel industry ambient particulate matter (PM) that contain high concentrations of PAHs and metals was done by treating human lung cancer cell-line, A549 and the cell lysates were analysed using quantitative label-free nano LC-MS/MS. A total of 18,562 peptides representing 1576 proteins were identified and quantified, with 196 proteins had significantly altered expression in the treated cells. Enrichment analyses revealed that proteins associated to redox homeostsis, metabolism, and cellular energy generation were inhibited while, proteins related to DNA damage and repair and other stresses were over expressed...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684090/predictors-of-poor-outcome-in-patients-with-pulmonary-arterial-hypertension-a-single-center-study
#4
Emilia Stepnowska, Ewa Lewicka, Alicja Dąbrowska-Kugacka, Ludmiła Daniłowicz-Szymanowicz, Paweł Zagożdżon, Rafał Kamiński, Zuzanna Lewicka-Potocka, Paweł Miękus, Dariusz Kozłowski, Wojciech Potocki, Grzegorz Raczak
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a rare disorder with unfavorable prognosis despite implementation of specific PAH-oriented therapy. The aim of the study was to define predictors of poor prognosis in patients from one center treated according to the Polish National Health Fund program. PATIENTS AND METHODS: Forty-seven consecutive patients (30 women; aged 39±17 years) with PAH diagnosis were enrolled to the study. Clinical assessment, laboratory measurements, electrocardiogram, echocardiography, 6-minute walk test, 24-hour Holter monitoring, cardiopulmonary exercise test and microvolt T-wave alternans test were performed during routine visits...
2018: PloS One
https://www.readbyqxmd.com/read/29684050/intronic-pah-gene-mutations-cause-a-splicing-defect-by-a-novel-mechanism-involving-u1snrnp-binding-downstream-of-the-5-splice-site
#5
Ainhoa Martínez-Pizarro, Maja Dembic, Belén Pérez, Brage S Andresen, Lourdes R Desviat
Phenylketonuria (PKU), one of the most common inherited diseases of amino acid metabolism, is caused by mutations in the phenylalanine hydroxylase (PAH) gene. Recently, PAH exon 11 was identified as a vulnerable exon due to a weak 3' splice site, with different exonic mutations affecting exon 11 splicing through disruption of exonic splicing regulatory elements. In this study, we report a novel intron 11 regulatory element, which is involved in exon 11 splicing, as revealed by the investigated pathogenic effect of variants c...
April 23, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29682499/paracest-agents-encapsulated-in-reverse-nano-assembled-capsules-racs-how-slow-molecular-tumbling-can-quench-cest-contrast
#6
Annah Farashishiko, Jacqueline R Slack, Mauro Botta, Mark Woods
Although paraCEST is a method with immense scope for generating image contrast in MRI, it suffers from the serious drawback of high detection limits. For a typical discrete paraCEST agent the detection limit is roughly an order of magnitude higher than that of a clinically used relaxation agent. One solution to this problem may be the incorporation of a large payload of paraCEST agents into a single macromolecular agent. Here we report a new synthetic method for accomplishing this goal: incorporating a large payload of the paraCEST agent DyDOTAM3+ into a Reverse Assembled nano-Capsule...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29681759/impacts-of-a-large-boreal-wildfire-on-ground-level-atmospheric-concentrations-of-pahs-vocs-and-ozone
#7
Gregory R Wentworth, Yayne-Abeba Aklilu, Matthew S Landis, Yu-Mei Hsu
During May 2016 a very large boreal wildfire burned throughout the Athabasca Oil Sands Region (AOSR) in central Canada, and in close proximity to an extensive air quality monitoring network. This study examines speciated 24-h integrated polycyclic aromatic hydrocarbon (PAH) and volatile organic compound (VOC) measurements collected every sixth day at four and seven sites, respectively, from May to August 2016. The sum of PAHs (ΣPAH) was on average 17 times higher in fire-influenced samples (852 ng m-3 , n = 8), relative to non-fire influenced samples (50 ng m-3 , n = 64)...
April 2018: Atmospheric Environment
https://www.readbyqxmd.com/read/29680762/removal-and-fate-of-polycyclic-aromatic-hydrocarbons-in-a-hybrid-anaerobic-anoxic-oxic-process-for-highly-toxic-coke-wastewater-treatment
#8
Wentao Zhao, Qian Sui, Xia Huang
Elimination of polycyclic aromatic hydrocarbons (PAHs) from coke wastewater is crucial to minimize the PAHs contamination levels to the environment. Knowledge about the characteristics of PAHs removal in biological treatment processes, especially hybrid systems, for real coke wastewater treatment has been very scarce. In this study, a lab-scale hybrid anaerobic-anoxic-oxic (A1 /A2 /O) process was used to treat highly toxic coke wastewater and operated more than 600 d at total hydraulic retention time (HRT) of 50 h, 40 h, 30 h, 20 h and internal mixed liquor recirculation ratio (R) of 3, 6, 9...
April 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29680741/etched-poly-ether-ether-ketone-jacket-stir-bar-with-detachable-dumbbell-shaped-structure-for-stir-bar-sorptive-extraction
#9
Wei Zhou, Chenlu Wang, Xuemei Wang, Zilin Chen
Development of stir bar sorptive extraction (SBSE) device with high stability and extraction efficiency is critical and challenging by date. In this work, etched poly(ether ether ketone) (PEEK) tube with high mechanical strength and large specific surface area was used as jacket for SBSE device. By etching with concentrated sulfuric acid, the smooth outer surface of PEEK become porous with plenty of micro holes, which was beneficial for coating of sorbents and significantly improved the extraction performance...
April 12, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29679939/semi-volatile-organic-compounds-in-the-snow-of-russian-arctic-islands-archipelago-novaya-zemlya
#10
A T Lebedev, D M Mazur, O V Polyakova, D S Kosyakov, A Yu Kozhevnikov, T B Latkin, I Andreeva Yu, V B Artaev
Environmental contamination of the Arctic has widely been used as a worldwide pollution marker. Various classes of organic pollutants such as pesticides, personal care products, PAHs, flame retardants, biomass burning markers, and many others emerging contaminants have been regularly detected in Arctic samples. Although numerous papers have been published reporting data from the Canadian, Danish, and Norwegian Arctic regions, the environmental situation in Russian Arctic remains mostly underreported. Snow analysis is known to be used for monitoring air pollution in the regions with cold climate in both short-term and long-term studies...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679599/mortality-in-pulmonary-arterial-hypertension-patients-treated-with-continuous-prostanoids
#11
S D Bartolome, N Sood, T S Shah, K Styrvoky, F T Torres, K M Chin
INTRODUCTION: Parenteral prostanoids are considered the treatment of choice for patients with severe pulmonary arterial hypertension (PAH). Prognostic studies for patients treated in the modern era are limited. METHODS: In this retrospective cohort study, patients initiating IV epoprostenol or IV or SC treprostinil therapy for PAH from 2007-2016 at UT Southwestern, Dallas, TX and Ohio State University, Columbus, OH were included. Transplant-free survival was assessed from the time of IV/SC initiation and from the time of first follow-up...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29676587/a-potential-role-for-exosomal-tctp-export-in-vascular-remodeling-in-pulmonary-arterial-hypertension
#12
Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, Mark L Ormiston, Stephen Moore, John Deighton, Lu Long, Xu Dong Yang, Duncan J Stewart, Nicholas W Morrell
Pulmonary arterial hypertension (PAH) is characterized by increased proliferation and resistance to apoptosis of pulmonary vascular cells. Increased expression of translationally controlled tumor protein (TCTP), a pro-survival and anti-apoptotic mediator, has recently been demonstrated in patients with hereditary PAH (HPAH) although its role in the pathobiology of PAH remains unclear. Silencing of TCTP in blood outgrowth endothelial cells (BOECs) isolated from control subjects led to significant changes in morphology, cytoskeletal organization, increased apoptosis and decreased directionality during migration...
April 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29674244/a-green-chemometrics-assisted-fluorimetric-detection-method-for-the-direct-and-simultaneous-determination-of-six-polycyclic-aromatic-hydrocarbons-in-oil-field-wastewaters
#13
Hui-Wen Gu, Shan-Hui Zhang, Bai-Chun Wu, Wu Chen, Jing-Bo Wang, Yang Liu
Oil-field wastewaters contain high level of polycyclic aromatic hydrocarbons (PAHs), which have to be analyzed to assess the environmental effects before discharge. In this work, a green fluorimetric detection method that combines excitation-emission matrix (EEM) fluorescence with parallel factor analysis (PARAFAC) algorithm was firstly developed to achieve the direct and simultaneous determination of six U.S. EPA PAHs in two different kinds of complex oil-field wastewaters. Due to the distinctive "second-order advantage", neither time-consuming sample pretreatments nor toxic organic reagents were involved in the determination...
April 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29674186/pulmonary-hypertension-real-world-data-from-a-portuguese-expert-referral-centre
#14
A Gomes, C Cruz, J Rocha, M Ricardo, M Vicente, A Melo, M Santos, L Carvalho, F Gonçalves, A Reis
BACKGROUND: Pulmonary hypertension (PH) is a heterogeneous, debilitating condition with highly relevant impact on functional capacity, quality of life, and life-expectancy. OBJECTIVES: This study aims to provide long-term data on the Portuguese PH population, by characterising the clinical presentation, evolution, and outcomes of PH patients in a specialised referral centre. METHODS: Retrospective analysis of a cohort of 101 patients with pre-capillary PH (pcPH) referenced to an expert tertiary care referral centre in northern Portugal from 2002 to 2013...
April 16, 2018: Pulmonology
https://www.readbyqxmd.com/read/29673911/targeting-the-rhoa-rock-pathway-to-regulate-t-cell-homeostasis-in-hypoxia-induced-pulmonary-arterial-hypertension
#15
Cheng Li, Ping-Ping Liu, Dou-Dou Tang, Rong Song, Yi-Qing Zhang, Si Lei, Shang-Jie Wu
BACKGROUND: Hypoxic pulmonary arterial hypertension (PAH) is a crippling disease with limited therapeutic methods. The imbalance of T helper 17 cell (Th17)/regulatory T cell (Treg) plays an important role in the development of Hypoxic PAH. However, whether targeting the ras homolog family member A-Rho kinase (RhoA-ROCK) pathway (activation and inhibition) by lysophosphatidic acid (LPA) and fasudil (FSD) regulate T-cell homeostasis in Hypoxic PAH remain unknown. OBJECTIVE: To examine the effects of LPA and FSD on hypoxic pulmonary vascular remodeling and homeostasis of Th17/Treg cells in Hypoxic PAH...
April 16, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29673765/three-dimensional-ionic-liquid-ferrite-functionalized-graphene-oxide-nanocomposite-for-pipette-tip-solid-phase-extraction-of-16-polycyclic-aromatic-hydrocarbons-in-human-blood-sample
#16
Yun Zhang, Yong-Gang Zhao, Wei-Sheng Chen, He-Li Cheng, Xiu-Qiong Zeng, Yan Zhu
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitously found in the environment and have been proved to be prospectively associated with the risk of cancer. In this study, a simple method based on pipette-tip solid phase extraction (PT-SPE) and gas chromatography-mass spectrometry (GC-MS) has been firstly developed for the determination of 16 PAHs in human whole blood. Three-dimensional ionic liquid-ferrite functionalized graphene oxide nanocomposite (3D-IL-Fe3 O4 -GO) was used as sorbent in PT-SPE. Compared with conventional SPE method, the PT-SPE method was solvent-saving (1...
March 21, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29672951/construction-of-polycyclic-%C3%AF-conjugated-systems-incorporating-an-azulene-unit-following-the-oxidation-of-1-8-diphenyl-9-10-bis-phenylethynyl-phenanthrene
#17
Akihito Konishi, Atsushi Morinaga, Makoto Yasuda
Polycyclic aromatic hydrocarbons (PHAs) that incorporate either heptagons or pentagons consist of non-planar molecular structures with unusual optoelectronic properties, and the design of a relatively simple and efficient method to construct these highly fused π-conjugated systems with odd-membered rings is in high demand. Herein, we describe using silver(I) cation to promote the efficient synthesis of azulene-embedded PAH 2, which is a structural isomer of tribenzo[fg,ij,rst]pentaphene 3, via tandem oxidative transannulation between the phenyl and arylethynyl moieties...
April 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29672222/macrophage-derived-extracellular-vesicles-mediates-smooth-muscle-hyperplasia-role-of-altered-mirna-cargo-in-response-to-hiv-infection-and-substance-abuse
#18
Himanshu Sharma, Mahendran Chinnappan, Stuti Agarwal, Pranjali Dalvi, Sumedha Gunewardena, Amy O'Brien-Ladner, Navneet K Dhillon
Our previous studies consistently demonstrate enhanced pulmonary vascular remodeling in HIV-infected intravenous drug users, and in simian immunodeficiency virus-infected macaques or HIV-transgenic rats exposed to opioids or cocaine. Although we reported an associated increase in perivascular inflammation, the exact role of inflammatory cells in the development of pulmonary vascular remodeling remains unknown. In this study, HIV-infected and cocaine (H+C)-treated human monocyte derived macrophages released a higher number of extracellular vesicles (EVs), compared to HIV-infected or uninfected cocaine-treated macrophages, with a significant increase in the particle size range to 100-150 nm...
April 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29672033/declining-pulmonary-function-in-populations-with-long-term-exposure-to-polycyclic-aromatic-hydrocarbons-enriched-pm2-5
#19
Meili Shen, Jie Xing, Qianpeng Ji, Zhihui Li, Yanhua Wang, Hongwei Zhao, Qingrong Wang, Ting Wang, Liwei Yu, Xiuchuan Zhang, Yaxin Sun, Zhihu Zhang, Yong Niu, Huanqiang Wang, Wen Chen, Yufei Dai, Wenge Su, Huawei Duan
This study assesses the effects of long-term exposure to ambient air pollutants on inflammatory response and lung function. We selected 390 male coke oven workers with exposure to polycyclic aromatic hydrocarbons (PAHs) and fine particulate matter (PM2.5) and 115 control workers. Pulmonary function tests were performed in all subjects. The average duration in the exposed group was 9.10 years. The total amount of PAHs was more enriched in PM2.5 which collected from the coke oven workshop compared with the control areas...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29669571/sex-differences-in-pulmonary-arterial-hypertension-role-of-infection-and-autoimmunity-in-the-pathogenesis-of-disease
#20
REVIEW
Kyle A Batton, Christopher O Austin, Katelyn A Bruno, Charles D Burger, Brian P Shapiro, DeLisa Fairweather
Registry data worldwide indicate an overall female predominance for pulmonary arterial hypertension (PAH) of 2-4 over men. Genetic predisposition accounts for only 1-5% of PAH cases, while autoimmune diseases and infections are closely linked to PAH. Idiopathic PAH may include patients with undiagnosed autoimmune diseases based on the relatively high presence of autoantibodies in this group. The two largest PAH registries to date report a sex ratio for autoimmune connective tissue disease-associated PAH of 9:1 female to male, highlighting the need for future studies to analyze subgroup data according to sex...
April 18, 2018: Biology of Sex Differences
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