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https://www.readbyqxmd.com/read/28822773/methodology-design-of-the-regional-sub-saharan-africa-total-diet-study-in-benin-cameroon-mali-and-nigeria
#1
Luc Ingenbleek, Eric Jazet, Anaclet D Dzossa, Samson B Adebayo, Julius Ogungbangbe, Sylvestre Dansou, Zima J Diallo, Christiant Kouebou, Abimbola Adegboye, Epiphane Hossou, Salimata Coulibaly, Sara Eyangoh, Bruno Le Bizec, Philippe Verger, Jean Kamanzi, Caroline Merten, Jean-Charles Leblanc
The core food model was described more than three decades ago, and has been used ever since to identify main food contributors to dietary intakes for both nutrients and other food chemicals. The Sub-Saharan Africa Total Diet Study (SSA-TDS) uses this model to describe the food consumption habits of some selected populations of Benin, Cameroon, Mali, and Nigeria, prior to use in the completion of quantitative risk assessments with regard to food chemicals. Food consumption data were derived from food expenditure data contained in national household budget surveys that were provided by the national institutes of statistics in each country...
August 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28822048/evaluation-of-methods-to-determine-adsorption-of-polycyclic-aromatic-hydrocarbons-to-dispersed-carbon-nanotubes
#2
Berit Glomstad, Lisbet Sørensen, Jingfu Liu, Mohai Shen, Florian Zindler, Bjørn M Jenssen, Andy M Booth
A number of methods have been reported for determining hydrophobic organic compound adsorption to dispersed carbon nanotubes (CNTs), but their accuracy and reliability remain uncertain. We have evaluated three methods to investigate the adsorption of phenanthrene (a model polycyclic aromatic hydrocarbon, PAH) to CNTs with different physicochemical properties: dialysis tube (DT) protected negligible depletion solid phase microextraction (DT-nd-SPME), ultracentrifugation, and filtration using various types of filters...
August 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28822013/biomonitoring-of-chemicals-in-biota-of-two-wetland-protected-areas-exposed-to-different-levels-of-environmental-impact-results-of-the-previeni-project
#3
Cristiana Guerranti, Guido Perra, Eva Alessi, Davide Baroni, Dante Caserta, Donatella Caserta, Augusto De Sanctis, Emiliano Leonida Fanello, Cinzia La Rocca, Michela Mariottini, Monia Renzi, Sabrina Tait, Carlo Zaghi, Alberto Mantovani, Silvano Ettore Focardi
The PREVIENI project (funded by the Ministry of Environment) investigated the exposure to endocrine disrupters in samples of human population and environmental biota in Italy. The environmental biomonitoring considered two Italian WWF Oasis, with the aim to compare the presence and effects of endocrine disruptors in organisms from two protected natural areas, respectively, upstream and downstream a chemical emission site. Chemical analysis of pollutants' tissue levels was made on tissues from earthworm, barbell, trout, and coot, selected as bioindicator organisms...
August 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28821056/fabrication-of-salecan-poly-amps-co-hmaa-semi-ipn-hydrogels-for-cell-adhesion
#4
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and has excellent physicochemical and biological properties. A series of hydrogels were fabricated from Salecan and poly(2-acrylamido-2-methylpropanesulfonic acid-co-N-hydroxymethyl acrylamide) (poly(AMPS-co-HMAA), PAH) by semi-IPN technique. The introduction of Salecan into the PAH network endows the system with enhanced cell adhesion properties. These semi-IPN hydrogels with open interconnected pores had pH and salt-sensitive swelling behavior. The increase in the content of hydrophilic Salecan could enhance the water uptake of the hydrogels...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821001/influence-on-serum-asymmetric-dimethylarginine-adma-concentrations-of-human-paraoxonase-1-polymorphism-q192r-and-exposure-to-polycyclic-aromatic-hydrocarbons-pahs-in-mexican-women-a-gene-environment-interaction
#5
Ángeles C Ochoa-Martínez, Tania Ruíz-Vera, Claudia I Almendarez-Reyna, Sandra T Orta-García, Iván N Pérez-Maldonado
It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit...
August 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28820995/influence-of-monitoring-data-selection-for-optimization-of-a-steady-state-multimedia-model-on-the-magnitude-and-nature-of-the-model-prediction-bias
#6
Hee Seok Kim, Dong Soo Lee
SimpleBox is an important multimedia model used to estimate the predicted environmental concentration for screening-level exposure assessment. The main objectives were (i) to quantitatively assess how the magnitude and nature of prediction bias of SimpleBox vary with the selection of observed concentration data set for optimization and (ii) to present the prediction performance of the optimized SimpleBox. The optimization was conducted using a total of 9604 observed multimedia data for 42 chemicals of four groups (i...
August 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28820526/silica-nanoparticle-monolayers-on-a-macroion-modified-surface-formation-mechanism-and-stability
#7
M Morga, Z Adamczyk, D Kosior
Even though silica nanoparticles and their monolayers find a broad field of applications, only a few studies providing a quantitative description of silica nanoparticle deposition at solid/liquid interfaces have been reported in the literature. Given the deficit of reliable experimental data, the goal of this work is to acquire thorough physicochemical characteristics of amorphous silica nanoparticle deposition. Silica nanoparticle monolayers of controlled coverage were formed on macroion (PAH)-modified mica...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819713/plasma-growth-differentiation-factor-15-is-a-potential-biomarker-for-pediatric-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease
#8
Gang Li, Yan Li, Xiao-Qiu Tan, Peng Jia, Jian Zhao, Dong Liu, Ting Wang, Bin Liu
We aimed to investigate plasma growth differentiation factor-15 (GDF-15) levels in pediatric pulmonary arterial hypertension secondary to congenital heart disease (PAH-CHD), and assess the association with hemodynamic parameters. Plasma GDF-15 levels were measured in children with PAH-CHD (n = 46) and compared to children with CHD without PAH (n = 39). Normal individuals (n = 30) served as health control group. Plasma GDF-15 levels were significantly elevated in patients with PAH-CHD compared with those with CHD without PAH (median 1415 ng/L, interquartile range [IQR] 926...
August 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28819545/circulating-mirnas-in-pediatric-pulmonary-hypertension-show-promise-as-biomarkers-of-vascular-function
#9
Vitaly O Kheyfets, Carmen C Sucharov, Uyen Truong, Jamie Dunning, Kendall Hunter, Dunbar Ivy, Shelley Miyamoto, Robin Shandas
BACKGROUND/OBJECTIVES: The objective of this study was to evaluate the utility of circulating miRNAs as biomarkers of vascular function in pediatric pulmonary hypertension. METHOD: Fourteen pediatric pulmonary arterial hypertension patients underwent simultaneous right heart catheterization (RHC) and blood biochemical analysis. Univariate and stepwise multivariate linear regression was used to identify and correlate measures of reactive and resistive afterload with circulating miRNA levels...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28818881/selexipag-for-the-treatment-of-connective-tissue-disease-associated-pulmonary-arterial-hypertension
#10
Sean Gaine, Kelly Chin, Gerry Coghlan, Richard Channick, Lilla Di Scala, Nazzareno Galiè, Hossein-Ardeschir Ghofrani, Irene M Lang, Vallerie McLaughlin, Ralph Preiss, Lewis J Rubin, Gérald Simonneau, Olivier Sitbon, Victor F Tapson, Marius M Hoeper
Patients with connective tissue disease-associated pulmonary arterial hypertension (PAH-CTD) have a poor prognosis compared with other aetiologies. The underlying CTD can influence treatment response and outcomes. We characterised the GRIPHON study PAH-CTD subgroup and evaluated response to selexipag.Of 334 patients with PAH-CTD, PAH was associated with systemic sclerosis (PAH-SSc) in 170, systemic lupus erythematosus (PAH-SLE) in 82 and mixed CTD/CTD-other in 82. For the primary composite endpoint of morbidity/mortality, hazard ratios (HR) and 95% CI were calculated using Cox proportional hazard models...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28818794/comprehensive-and-comparative-ecotoxicological-and-human-risk-assessment-of-polycyclic-aromatic-hydrocarbons-pahs-in-reef-surface-sediments-and-coastal-seawaters-of-iranian-coral-islands-persian-gulf
#11
Ali Ranjbar Jafarabadi, Alireza Riyahi Bakhtiari, Amirhossein Shadmehri Toosi
The concentration and spatial distribution along with ecotoxicological risk of 30 polycyclic aromatic hydrocarbons were investigated in the reef surface sediments (RSSs) and coastal seawater (CSW) of ten coral Islands from the Persian Gulf, Iran, in January 2015. For all sampling sites, assessment of ecological risk was undertaken using several approaches. Mean concentration of ∑30PAHs varied between 70 and 884ngL(-l) with an overall mean value of 464ngL(-l) in the CSW, while the RSS ranged from 274 to 1098ngg(-1)dw with a total average of 619ngg(-1)dw...
August 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28818587/phenanthrene-responsive-micrornas-and-their-targets-in-wheat-roots
#12
Jinfeng Li, Le Yue, Yu Shen, Yu Sheng, Xinhua Zhan, Guohua Xu, Baoshan Xing
MicroRNAs (miRNAs) play key roles in plant growth, development and responses to abiotic stress. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants. However, it is yet unknown how miRNAs work during PAH uptake by plant roots. Thus, in this study we ascertain phenanthrene (a model PAH)-responsive miRNAs using small RNA high-throughput deep sequencing and their target genes in wheat roots. We identified 108 conserved and non-conserved miRNA members belonging to 82 miRNA families and found 11 differentially expressed miRNAs, among which four miRNAs (miR156, miR164, miR171a and miR9678-3p) were up-regulated and the other seven miRNAs (miR398, miR531, miR1121, miR5048-5p, miR9653b, miR9773 and miR9778) were down-regulated...
August 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28817465/new-insights-into-the-recognition-classification-and-management-of-systemic-sclerosis-associated-pulmonary-hypertension
#13
Christopher J Mullin, Stephen C Mathai
PURPOSE OF REVIEW: Pulmonary hypertension is a common complication of systemic sclerosis (SSc), and remains a leading cause of morbidity and mortality. We will review recent developments in the recognition, classification and treatment of pulmonary hypertension in SSc. RECENT FINDINGS: Advances in screening for pulmonary arterial hypertension (PAH) and use of exercise haemodynamics may help to identify pulmonary vascular disease earlier in SSc. Recent studies have led to changes in recommendations for adjunct therapy and selection of pulmonary vasodilators for the treatment of SSc-associated PAH...
August 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28816428/aqueous-exfoliation-of-graphite-into-graphene-assisted-by-sulfonyl-graphene-quantum-dots-for-photonic-crystal-applications
#14
Minxiang Zeng, Smit A Shah, Dali Huang, Dorsa Parviz, Yi-Hsien Yu, Xuezhen Wang, Micah J Green, Zhengdong Cheng
We investigate the π-π stacking of polyaromatic hydrocarbons (PAHs) with graphene surfaces, showing that such interactions are general across a wide range of PAH sizes and species, including graphene quantum dots. We synthesized a series of graphene quantum dots with sulfonyl, amino and carboxylic functional groups and employed them to exfoliate and disperse pristine graphene in water. We observed that sulfonyl-functionalized graphene quantum dots were able to stabilize the highest concentration of graphene in comparison to other functional groups; this is consistent with prior findings by pyrene...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816352/pulmonary-artery-wave-propagation-and-reservoir-function-in-conscious-man-impact-of-pulmonary-vascular-disease-respiration-and-dynamic-stress-tests
#15
Junjing Su, Charlotte Manisty, Ulf Simonsen, Luke S Howard, Kim H Parker, Alun D Hughes
Detailed hemodynamic analysis may provide novel insights into the pulmonary circulation. Therefore, wave intensity and reservoir-excess pressure analyses were applied in the pulmonary artery to characterise changes in wave propagation and reservoir function during spontaneous respiration and dynamic stress tests. Right heart catheterisation was performed using a pressure and Doppler flow sensor tipped guidewire to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery in control subjects and patients with pulmonary arterial hypertension (PAH) at rest...
August 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28815369/suspended-particulate-matter-collection-methods-influence-the-quantification-of-polycyclic-aromatic-compounds-in-the-river-system
#16
Fayez Abuhelou, Laurence Mansuy-Huault, Catherine Lorgeoux, Delphine Catteloin, Valéry Collin, Allan Bauer, Hussein Jaafar Kanbar, Renaud Gley, Luc Manceau, Fabien Thomas, Emmanuelle Montargès-Pelletier
In this study, we compared the influence of two different collection methods, filtration (FT) and continuous flow field centrifugation (CFC), on the concentration and the distribution of polycyclic aromatic compounds (PACs) in suspended particulate matter (SPM) occurring in river waters. SPM samples were collected simultaneously with FT and CFC from a river during six sampling campaigns over 2 years, covering different hydrological contexts. SPM samples were analyzed to determine the concentration of PACs including 16 polycyclic aromatic hydrocarbons (PAHs), 11 oxygenated PACs (O-PACs), and 5 nitrogen PACs (N-PACs)...
August 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28814664/pulmonary-arterial-hypertension-treatment-with-carvedilol-for-heart-failure-a-randomized-controlled-trial
#17
Samar Farha, Didem Saygin, Margaret M Park, Hoi I Cheong, Kewal Asosingh, Suzy Aa Comhair, Olivia R Stephens, Emir C Roach, Jacqueline Sharp, Kristin B Highland, Frank P DiFilippo, Donald R Neumann, W H Wilson Tang, Serpil C Erzurum
BACKGROUND: Right-sided heart failure is the leading cause of death in pulmonary arterial hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β-adrenoreceptor (βAR) abnormalities are found in PAH. Based on successful therapy of left heart failure with β-blockade, the safety and benefits of the nonselective β-blocker/vasodilator carvedilol were evaluated in PAH. METHODS: PAH Treatment with Carvedilol for Heart Failure (PAHTCH) is a single-center, double-blind, randomized, controlled trial...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28812058/environmental-pollutants-and-neurodevelopment-review-of-benefits-from-closure-of-a-coal-burning-power-plant-in-tongliang-china
#18
Vrinda Kalia, Frederica Perera, Deliang Tang
Background. Understanding preventable causes of neurodevelopmental disorders is a public health priority. Polycyclic aromatic hydrocarbons (PAH) from combustion of fossil fuel, lead, and mercury are among known neurodevelopmental toxicants. Method. For the first time, we comprehensively review the findings from a study by the Columbia Center for Children's Environmental Health and Chinese partners that followed 2 groups of mother-child pairs, one from 2002 and another from 2005, in Tongliang County, China. Pregnant mothers in the 2 cohorts experienced different exposure to PAH because a local coal-burning power plant was shut down in 2004...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28810687/the-characterization-of-polycyclic-aromatic-hydrocarbons-in-northeastern-us-trucking-terminals
#19
Erica D Walker, Jaime E Hart, Eric Garshick, Jennifer M Cavallari, Mary E Davis, Thomas J Smith, Francine Laden
In recent years, significant attention has been given to polycyclic aromatic hydrocarbons (PAHs) exposures given their mutagenic and carcinogenic properties. However, levels of exposure and the key determinants of exposure are not well defined for the trucking industry. We measured ultrafine particle characteristics at 10 trucking terminals of varying operating size and location in the Northeast region of the United States using particle concentration counter and a surface area analyzer. Multivariate mixed-effects linear regression models were used to assess determinants of the concentration of total bound PAHs (tPAH), the total aerosol active surface area (AS), and the ratio tPAH/AS overall and individually within docks, trucking cabs, and administrative offices...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28810598/differentially-methylated-regions-in-patients-with-rheumatic-heart-disease-and-secondary-pulmonary-arterial-hypertension
#20
Dawei Zheng, Xiaoying Chen, Ni Li, Lebo Sun, Qingyun Zhou, Huoshun Shi, Guodong Xu, Jing Liu, Limin Xu, Shiwei Duan, Guofeng Shao
The aim of the present study was to identify differentially methylated regions (DMRs) in patients with rheumatic heart disease and secondary pulmonary arterial hypertension (RHD-PAH). A genome-wide DNA methylation assay was performed between 6 patients with RHD-PAH and 6 healthy controls using an Illumina Infinium HumanMethylation450 BeadChip kit. The Limma software package was subsequently used to identify significant DMRs. A total of 40 hypome-thylated and 64 hypermethylated CpG sites were identified between the RHD-PAH group and the control group...
August 2017: Experimental and Therapeutic Medicine
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