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J Zhang, B Wu, M Zhou, D Liu, L Fan, D Wei, H Yang, J Y Chen
Objective: To investigate the timing and complications of lung transplantation for the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). Method: The clinical data of connective tissue-associated disease lung transplantation recipients from September, 2015 to February, 2017 were collected. Results: 11 patients with CTD-ILD were evaluated by lung transplantation and were treated with lung transplantation. Including 2 cases dermatomyositis/polymyositis and interstitial lung disease (PM/DM-ILD), 4 cases rheumatoid arthritis and interstitial lung disease (RA-ILD), 4 cases of primary Sjgren's syndrome and interstitial lung disease (pSS-ILD), 1 case of systemic sclerosis and interstitial lung disease (SSc-ILD)...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
Yimeng Tan, Tao Tang, Sandong Yang, Mingzhu Xia, Fengyun Wang, Tong Li
Supramolecular solvent (SUPRAS) is a nano-structured liquid generated from amphiphiles through a sequential self-assembly process. It is an efficient and excellent solvent for the sample extraction. In this paper, a method to directly extract and rapidly analyze polycyclic aromatic hydrocarbons (PAHs) in water samples by high performance liquid chromatography-fluorescence detection (HPLC-FLD) was developed. The composition and amount of SUPRAS were optimized and practical samples were tested. It indicated that the combination of tetrahydrofuran and 1-octanol was a suitable SUPRAS for the extraction of four PAHs with recoveries between 89...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
Jiaying Zhao, Xiaomin Li, Xiaohua Lu, Qinghe Zhang, Weibing Zhang
A method for the determination of four polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]anthracene, chrysene, benzo[b]fluoranthene and benzo[a]pyrene in olive oil by high performance liquid chromatography-fluorescent detection (HPLC-FLD) was developed. The olive oil samples were diluted with isopropanol and cleaned-up by a solid phase extraction cartridge with π-π specificity. Critical isomers were separated by gradient elution with water-acetonitrile on an Agilent ZORBAX Eclipse PAH column (100 mm×2...
July 8, 2017: Se Pu, Chinese Journal of Chromatography
Haijing Li, Xiangwen Zhang
As coking precursors, aromatic hydrocarbons have an effect on the cracking stability of fuels. A method for identifying and quantitating aromatics in the supercritical cracking products of jet fuel was established by comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC×GC-MS). The effects of main chromatographic conditions such as initial oven temperature and modulation period on the separation of supercritical cracking products were studied. The method has good separation ability for polycyclic aromatic hydrocarbons (PAH) isomers...
August 8, 2017: Se Pu, Chinese Journal of Chromatography
Meifei Wang, Lili Yang, Enyu Hu
A method by using microwave extraction and high performance liquid chromatography was developed to determine polycyclic aromatic hydrocarbons (PAHs) in airborne particles. The glass/quartz fiber filter, on which particles adsorbed, was extracted with a mixed solvent n-hexane/acetone (1:1, v/v) using microwave, and the subsequent purification of the extract was carried out by a florisil cartridge. The prepared sample was determined by high performance liquid chromatography coupled with photodiode array (PDA) and fluorescence dual-detector...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
Joey S Stevens, Stephanie Padilla, David M DeMarini, Deborah L Hunter, W Kyle Martin, Leslie C Thompson, M Ian Gilmour, Mehdi S Hazari, Aimen K Farraj
Exposure to fine particulate matter (PM) air pollution causes adverse cardiopulmonary outcomes. Yet the limited capacity to readily identify contributing PM sources and associated PM constituents in any given ambient air shed impedes risk assessment efforts. The health effects of PM have been attributed in part to its capacity to elicit irritant responses. A variety of chemicals trigger irritant behavior responses in zebrafish that can be easily measured. The purposes of this study were to examine the utility of zebrafish locomotor responses in the toxicity assessment of fine PM and its chemical fractions and uncover mechanisms of action...
October 17, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
Scott A Barman, David Fulton
Pulmonary arterial hypertension (PAH) is a progressive disease arising from remodeling and narrowing of pulmonary arteries (PA) resulting in high pulmonary arterial blood pressure and ultimately right ventricular failure. Elevated production of reactive oxygen species (ROS) by NADPH oxidase 4 (Nox4), a constitutively active enzyme, has been associated with oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis. Further, elevated expression of Nox4 has been reported in a number of cardiovascular diseases, including atherosclerosis, hypertension, cardiac failure, ischemic stroke, and PAH...
2017: Advances in Experimental Medicine and Biology
Jason Weatherald, Laurent Savale, Marc Humbert
PURPOSE OF REVIEW: The purpose of this review was to outline the mechanisms and to review recent literature on pulmonary arterial hypertension (PAH) medications in group 5 pulmonary hypertension (PH). RECENT FINDINGS: The first steps in management are to understand the mechanisms and hemodynamic profile and to exclude chronic thromboembolic disease. Recent studies in the past 5 years have found that PAH medications may improve hemodynamics in patients with pre-capillary pulmonary hypertension due to sarcoidosis, pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis, and myeloproliferative disorders with dasatinib-induced PH...
October 18, 2017: Current Hypertension Reports
Jacob L Johansen, Bridie J M Allan, Jodie L Rummer, Andrew J Esbaugh
Global demand for energy and oil-based products is progressively introducing petrogenic polycyclic aromatic hydrocarbons (PAHs) into sensitive marine environments, primarily from fossil-fuel exploration, transport, and urban and industrial runoff. These toxic pollutants are found worldwide, yet the long-term ecological effects on coral reef ecosystems are unknown. Here, we demonstrate that oil exposure spanning PAH concentrations that are environmentally relevant for many coastal marine ecosystems (≤5.7 μg l(-1)), including parts of the Great Barrier Reef, Red Sea, Asia and the Caribbean, causes elevated mortality and stunted growth rates in six species of pre-settlement coral reef fishes, spanning two evolutionarily distinct families (Pomacentridae and Lethrinidae)...
August 2017: Nature ecology & evolution
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Maria Helena Guerra Andersen, Anne Thoustrup Saber, Per Axel Clausen, Julie Elbæk Pedersen, Mille Løhr, Ali Kermanizadeh, Steffen Loft, Niels Ebbehøj, Åse Marie Hansen, Peter Bøgh Pedersen, Ismo Kalevi Koponen, Eva-Carina Nørskov, Peter Møller, Ulla Vogel
This study investigated a number of biomarkers, associated with systemic inflammation as well as genotoxicity, in 53 young and healthy subjects participating in a course to become firefighters, while wearing personal protective equipment (PPE). The exposure period consisted of a 3-day training course where the subjects participated in various live-fire training exercises. The subjects were instructed to extinguish fires of either wood or wood with electrical cords and mattresses. The personal exposure was measured as dermal polycyclic aromatic hydrocarbon (PAH) concentrations and urinary excretion of 1-hydroxypyrene (1-OHP)...
October 13, 2017: Mutagenesis
Amanda A Brennan, Nathan Johnson
The over- or under-prediction of risk in moderately contaminated sediments can have a large impact on the nature of applied management strategies since concentrations border on being toxic or not toxic. Project managers should give significant consideration as to how moderate levels of contaminants in native sediments and dredged material used for restoration will impact recovery of habitat. Total solid-phase (Ctotal ) and porewater (Cfree ) polycyclic aromatic hydrocarbons (PAHs) were quantified in native sediments and dredged material to determine if the predictions of risk from Ctotal are consistent with those based on Cfree ...
October 17, 2017: Integrated Environmental Assessment and Management
Chao Yuan, Min Xu, Rong Rong, Yong Mei, Wenyan Cai, Lin Li, Yao Xue, Baoli Zhu, Kai Sun, Lei Han
miR-200c is an antioncogene in multiple tumors. However, its function in the pathogenesis of pulmonary arterial hypertension (PAH) has not been thoroughly investigated nor understood. In this study, we discovered that miR-200c was able to substantially upregulate in pulmonary arterial smooth muscle cells (PASMCs) treated with endothelin-1 (ET-1). miR-200c also induced cell proliferation and suppressed cell apoptosis in PASMCs in vitro. However, miR-200c had no effect on G1/S/G2 transitions during the cell cycle...
October 16, 2017: IUBMB Life
Jennifer L A Keir, Umme S Akhtar, David M J Matschke, Tracy L Kirkham, Hing Man Chan, Pierre Ayotte, Paul A White, Jules M Blais
Occupational exposures to combustion emissions were examined in Ottawa Fire Service (OFS) firefighters. Paired urine and dermal wipe samples (i.e., pre- and post-event) as well as personal air samples and fire event questionnaires were collected from 27 male OFS firefighters. A total of 18 OFS office workers were used as additional controls. Exposures to polycyclic aromatic hydrocarbons (PAHs) and other organic mutagens were assessed by quantification of urinary PAH metabolite levels, levels of PAHs in dermal wipes and personal air samples, and urinary mutagenicity using the Salmonella mutagenicity assay (Ames test)...
October 18, 2017: Environmental Science & Technology
Michal Schäfer, Uyen Truong, Lorna P Browne, Gareth J Morgan, Michael Ross, Richard Ing, Kendall S Hunter, Vitaly O Kheyfets, Steven H Abman, D Dunbar Ivy, Neil Wilson
We sought to compare pulmonary flow hemodynamic indices obtained by Fick and thermodilution catheterization techniques with phase-contrast MRI (PC-MRI) in children with diverse etiologies of pulmonary arterial hypertension (PAH). Calculation of pulmonary flow ([Formula: see text]) using the Fick principle in most catheter laboratories relies on an estimate of oxygen consumption which may limit its reliability. Flow hemodynamic indices acquired from thirty patients with PAH who underwent successful same-day PC-MRI and catheterization were evaluated for absolute and percent bias...
October 17, 2017: Pediatric Cardiology
Jianchun Yang, Xin Che, Rui Shen, Can Wang, Xueming Li, Weimin Chen
A high-sensitivity photonic crystal fiber long-period grating (PCF-LPG) methane sensor with cryptophane-A-6Me absorbed on a poly(acrylic acid)-carbon nanotubes/ polypropylene amine hydrochloride (PAA-CNTs/PAH) nanofilm was investigated. The sensing film was coated onto the internal surface of a photonic crystal fiber cladding air holes by an electrostatic self-assembly technique. Based on a finite element method and the coupled local-mode theory, the effects of the sensing film's refractive index (RI) and thickness on the resonant wavelength were theoretically and numerically analyzed...
August 21, 2017: Optics Express
Marek Roszko, Marta Kamińska, Krystyna Szymczyk, Renata Jędrzejczak
The aim of this work was to assess dietary risk resulting from consumption of polycyclic aromatic hydrocarbons (PAHs) with tea infusions. To this end, levels of 28 PAHs in black, green, red and white teas available on the Polish retail market have been assessed. Profiles and correlation between concentrations of individual PAHs have been identified. A model study on transfer of PAHs from tea leaves into tea preparations has been conducted. Relatively high concentrations of 28 evaluated PAHs have been found in 58 tested samples of black, green, red and white teas sampled on the Polish retail market...
October 17, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Dongmei Jiang, Yu Chen, Yuxiang Zhu, Guosheng Fu, Shiming Xu
Pulmonary arterial hypertension (PAH) is a serious pulmonary vascular disease. The changes in the structure, function and metabolism of endothelial cells are some of the important features of PAH. Previous studies have demonstrated that the mevalonate pathway is important in cardiovascular remodeling. However, whether the mevalonate pathway is involved in the development of PAH remains to be elucidated. The present study aimed to investigate the expression pattern of mevalonate pathway-related enzymes in monocrotaline (MCT)-induced PAH...
October 17, 2017: Molecular Medicine Reports
Sou Hyun Kim, Dahye Yoon, Yun-Hee Lee, Jaewon Lee, Nam Deuk Kim, Suhkmann Kim, Young-Suk Jung
Polycyclic aromatic hydrocarbons (PAHs) are widespread contaminants resulting from the incomplete combustion of organic materials in the environment. The primary concern for the hazardous effect of PAHs is their ability to activate the pathway linked to the aryl hydrocarbon receptor (AhR) and lead to carcinogenesis. While previous research has demonstrated that oxidative stress plays a key role in the AhR-dependent toxic response, the effect of PAHs on the biosynthesis of glutathione (GSH), which is a powerful endogenous antioxidant, has not been extensively investigated...
October 11, 2017: International Journal of Molecular Medicine
Erin M Adkins, J Houston Miller
Trends linking the topological characteristics of polynuclear aromatic hydrocarbons (PAH) to their electronic properties are reported. TD-DFT electronic spectra computations, using the 6-31G* basis set and B3LYP exchange correlation functional, were calculated for a series of PAH, allowing for the HOMO-LUMO gaps to be reported. Clar structures provide an avenue to link the physical structure and the aromaticity of the molecule; which, when extended by bond length and harmonic oscillator model of aromaticity analysis, provide powerful tools to understand the link between electronic and physical structure...
October 17, 2017: Physical Chemistry Chemical Physics: PCCP
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