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Ovarian cancer etiology

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https://www.readbyqxmd.com/read/29321816/erbb-signaling-in-ctcs-of-ovarian-cancer-and-glioblastoma
#1
REVIEW
Anjali Geethadevi, Deepak Parashar, Erin Bishop, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Circulating Tumor Cells (CTCs) are floating cell populations, which are resistant to anoikis after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. CTCs are considered as seed cells for metastasis, and thus isolation of CTCs does not require any invasive procedure. Based on the nature and location of ovarian cancer and glioblastoma, the role of CTCs and hematogenous (carried by blood) spreading of tumor cells in these cancers were not understood well...
November 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29303936/type-i-versus-type-ii-endometrial-cancer-differential-impact-of-comorbidity
#2
Mette Calundann Noer, Sofie Leisby Antonsen, Bent Ottesen, Ib Jarle Christensen, Claus Høgdall
OBJECTIVE: Two distinct types of endometrial carcinoma (EC) with different etiology, tumor characteristics, and prognosis are recognized. We investigated if the prognostic impact of comorbidity varies between these 2 types of EC. Furthermore, we studied if the recently developed ovarian cancer comorbidity index (OCCI) is useful for prediction of survival in EC. MATERIALS AND METHODS: This nationwide register-based cohort study was based on data from 6487 EC patients diagnosed in Denmark between 2005 and 2015...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29290361/dietary-inflammatory-index-and-ovarian-cancer-risk-in-a-new-jersey-case-control-study
#3
Nitin Shivappa, James R Hébert, Lisa E Paddock, Lorna Rodriguez-Rodriguez, Sara H Olson, Elisa V Bandera
OBJECTIVE: Diet may influence the development of ovarian cancer. Although it has been shown that inflammation plays an important etiologic role in ovarian carcinogenesis, little is known about the influence of the inflammatory potential of food consumption. The aim of this study was to evaluate the effect of a proinflammatory diet, as indicated by a high dietary inflammatory index (DII®) score, on ovarian cancer risk, in a New Jersey population. METHODS: Data from a case-control study conducted in New Jersey were used to estimate the relation between DII score and the risk for ovarian cancer...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29204511/smarca4-germline-gene-mutation-in-a-patient-with-epithelial-ovarian-a-case-report
#4
Reshma Muppala, Talia Donenberg, Marilyn S Huang, Matthew P Schlumbrecht
Background: SMARCA4 is gene whose protein product participates in chromatin remodeling. Somatic mutations in this gene are associated with non-small cell lung cancer and malignant rhabdoid tumors, and both germline and somatic mutations are seen with small cell carcinoma of the ovary, hypercalcemic type. To date, there are no data identifying an association with more common epithelial carcinomas of the ovary. Case: The patient is a 57-year-old female without any significant family history of cancer, diagnosed with high-grade serous carcinoma of the ovary...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29188658/assessing-local-stromal-alterations-in-human-ovarian-cancer-subtypes-via-second-harmonic-generation-microscopy-and-analysis
#5
Kirby R Campbell, Paul J Campagnola
The collagen architecture in all human ovarian cancers is substantially remodeled, where these alterations are manifested in different fiber widths, fiber patterns, and fibril size and packing. Second harmonic generation (SHG) microscopy has differentiated normal tissues from high-grade serous (HGS) tumors with high accuracy; however, the classification between low-grade serous, endometrioid, and benign tumors was less successful. We postulate this is due to known higher genetic variation in these tissues relative to HGS tumors, which are genetically similar, and this results in more heterogeneous collagen remodeling in the respective matrix...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29113037/vitamin-d-and-vdr-in-gynecological-cancers-a-systematic-review
#6
REVIEW
Eileen Deuster, Udo Jeschke, Yao Ye, Sven Mahner, Bastian Czogalla
In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers...
November 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29083341/a-case-of-refractary-epilepsy-and-related-pain-due-to-dysmenorrhea-solved-with-loading-dose-of-lacosamide-clinical-and-neurophysiological-correlates
#7
Nicolino Marchitto, Umberto Ceratti, Serenella Dalmaso, Gianfranco Raimondi
 In most cases, the etiology of epilepsy is unknown, although some individuals may develop epilepsy as a result of certain brain injuries, following a stroke, a brain tumor or because of drugs and alcohol. Even some rare genetic mutations may be related to the onset of the condition. Seizures are the result of excessive and abnormal activity of neurons in the cerebral cortex. In this case report we show a clinical case of refractory epilepsy due to pain related to uncontrolled dysmenorrhea. The patient, 43 yrs old, had a history of epilepsy of 20 years and ovarian cancer...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29061967/high-grade-serous-ovarian-carcinomas-originate-in-the-fallopian-tube
#8
S Intidhar Labidi-Galy, Eniko Papp, Dorothy Hallberg, Noushin Niknafs, Vilmos Adleff, Michael Noe, Rohit Bhattacharya, Marian Novak, Siân Jones, Jillian Phallen, Carolyn A Hruban, Michelle S Hirsch, Douglas I Lin, Lauren Schwartz, Cecile L Maire, Jean-Christophe Tille, Michaela Bowden, Ayse Ayhan, Laura D Wood, Robert B Scharpf, Robert Kurman, Tian-Li Wang, Ie-Ming Shih, Rachel Karchin, Ronny Drapkin, Victor E Velculescu
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients...
October 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29057034/oxidative-stress-and-endometriosis-a-systematic-review-of-the-literature
#9
REVIEW
Gennaro Scutiero, Piergiorgio Iannone, Giulia Bernardi, Gloria Bonaccorsi, Savino Spadaro, Carlo Alberto Volta, Pantaleo Greco, Luigi Nappi
Endometriosis is one of the most common gynaecologic diseases in women of reproductive age. It is characterized by the presence of endometrial tissue outside the uterine cavity. The women affected suffer from pelvic pain and infertility. The complex etiology is still unclear and it is based on three main theories: retrograde menstruation, coelomic metaplasia, and induction theory. Genetics and epigenetics also play a role in the development of endometriosis. Recent studies have put the attention on the role of oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, which may be implicated in the pathophysiology of endometriosis causing a general inflammatory response in the peritoneal cavity...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29016487/ovarian-vein-thrombosis-incidence-of-recurrent-venous-thromboembolism-and-survival
#10
Charles J Lenz, Waldemar E Wysokinski, Stanislav Henkin, Kevin P Cohoon, Ana Casanegra, Benjamin S Simmons, Rayya A Saadiq, Paul R Daniels, Ewa M Wysokinska, Haraldur Bjarnason, Robert D McBane
OBJECTIVE: To identify the risk of venous thromboembolism recurrence, major bleeding, and mortality in patients with ovarian vein thrombosis so as to better define optimal treatment strategies. METHODS: Patients with ovarian vein thrombosis (1990-2015) and age- and gender-matched patients with contemporary leg deep vein thrombosis (DVT) were assessed for differences in etiology, venous thromboembolism recurrence, and survival in a case-control study. RESULTS: Over the timeframe of this study, only 219 ovarian vein thrombosis cases were identified compared with 13,417 leg DVTs...
November 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28985766/mutations-in-brca1-brca2-and-other-breast-and-ovarian-cancer-susceptibility-genes-in-central-and-south-american-populations
#11
REVIEW
Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco, Raul Godoy
Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes. In non-carriers of BRCA1/2 mutations, disease susceptibility may be explained of a small number of mutations in BRCA1/2 and a much higher proportion of mutations in ethnicity-specific moderate- and/or low-penetrance genes. In Central and South American populations, studied have focused on analyzing the distribution and prevalence of BRCA1/2 mutations and other susceptibility genes that are scarce in Latin America as compared to North America, Europe, Australia, and Israel...
October 6, 2017: Biological Research
https://www.readbyqxmd.com/read/28889025/industrial-pollution-and-cancer-in-spain-an-important-public-health-issue
#12
Pablo Fernández-Navarro, Javier García-Pérez, Rebeca Ramis, Elena Boldo, Gonzalo López-Abente
Cancer can be caused by exposure to air pollution released by industrial facilities. The European Pollutant Release and Transfer Register (E-PRTR) has made it possible to study exposure to industrial pollution. This study seeks to describe the industrial emissions in the vicinity of Spanish towns and their temporal changes, and review our experience studying industrial pollution and cancer. Data on industrial pollutant sources (2007-2010) were obtained from the E-PRTR registries. Population exposure was estimated by the distance from towns to industrial facilities...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28834887/c-reactive-protein-and-risk-of-ovarian-cancer-a-systematic-review-and-meta-analysis
#13
REVIEW
Jing Li, Xuedan Jiao, Zhongfu Yuan, Haifeng Qiu, Ruixia Guo
BACKGROUND: Although several studies have suggested an association between elevated C-reactive protein (CRP) and ovarian cancer risk, others have yielded contradictory results. To address this issue, we conducted a meta-analysis. METHODS: Studies were identified by searching PubMed and EMBASE up to July 2017 without language restrictions. Six case-control studies and 1 cohort study were included, including 1898 ovarian cancer cases. Pooled risk estimates were generated by using the fixed-effect model or the random-effect model based on the heterogeneity between studies...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28818315/screening-for-familial-cancer-risk-focus-on-breast-cancer
#14
REVIEW
Christine Rousset-Jablonski, Anne Gompel
A breast or an ovarian cancer occurring at a young age and/or in a family where other cases preexist suggests that those patients should be candidates for screening for mutations. Despite decades of medical research, less than 30% of cases with a suggestive personal and/or family history of hereditary breast cancer have an identified causative gene mutation. The vast majority of these cases are due to a mutation in one of the highly penetrant breast cancer genes (BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11) and various guidelines direct the management of these patients...
November 2017: Maturitas
https://www.readbyqxmd.com/read/28782606/epigenetics-in-ovarian-cancer
#15
REVIEW
Yanina Natanzon, Ellen L Goode, Julie M Cunningham
Ovarian cancer is a disease with a poor prognosis and little progress has been made to improve treatment. It is now recognized that there are several histotypes of ovarian cancer, each with distinct epidemiologic and genomic characteristics. Cancer therapy is moving beyond classical chemotherapy to include epigenetic approaches. Epigenetics is the dynamic regulation of gene expression by DNA methylation and histone post translational modification in response to environmental cues. Improvement in technology to study DNA methylation has enabled a more agnostic approach and, with larger samples sets, has begun to unravel how epigenetics contributes to the etiology, response to chemotherapy and prognosis in of ovarian cancer...
August 3, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28780673/investigating-the-genetic-relationship-between-alzheimer-s-disease-and-cancer-using-gwas-summary-statistics
#16
Yen-Chen Anne Feng, Kelly Cho, Sara Lindstrom, Peter Kraft, Jean Cormack, Liming Liang, Jane A Driver
Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 9931 to 54,162; SNPs were imputed to the 1000 Genomes European panel. Our results based on cross-trait LD Score regression showed a significant positive genetic correlation between AD and five cancers combined (colon, breast, prostate, ovarian, lung; r g = 0...
October 2017: Human Genetics
https://www.readbyqxmd.com/read/28748634/timing-of-births-and-oral-contraceptive-use-influences-ovarian-cancer-risk
#17
Anna H Wu, Celeste Leigh Pearce, Alice W Lee, Chiuchen Tseng, Anjali Jotwani, Prusha Patel, Malcolm C Pike
Increasing parity and duration of combined oral contraceptive (COC) use provide substantial protection against ovarian carcinoma (cancer). There are limited data on the impact of the age of the births or age of COC use on reducing ovarian cancer risk. Here, we examined the effects of age at first and last births and age at use of COCs using data from studies conducted in Los Angeles County, California, USA (1,632 cases, 2,340 controls). After adjusting for the number of births, every 5 years that a first birth was delayed reduced the risk of ovarian cancer by 13% (95% CI 5-21%; p = 0...
December 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28711970/does-a-male-polycystic-ovarian-syndrome-equivalent-exist
#18
REVIEW
R Cannarella, R A Condorelli, L M Mongioì, S La Vignera, A E Calogero
The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (<35 years) androgenetic alopecia (AGA). Hence, this feature has been proposed as a clinical sign of the male PCOS equivalent. Clinical evidence has shown that men with early onset AGA have hormonal and metabolic abnormalities...
July 15, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28692125/steroid-metabolism-gene-polymorphisms-and-their-implications-on-breast-and-ovarian-cancer-prognosis
#19
E V W Dos Santos, L N R Alves, I D Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instability) and LOH (loss of heterozygosity) in AR, ERβ and CYP19 genes in women from Espírito Santo State, Brazil. The study population consisted of 107 female breast and 24 ovarian tumors...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28681696/mass-spectrometric-profiling-reveals-association-of-n-glycan-patterns-with-epithelial-ovarian-cancer-progression
#20
Huanhuan Chen, Zaian Deng, Chuncui Huang, Hongmei Wu, Xia Zhao, Yan Li
Aberrant changes of N-glycan modifications on proteins have been linked to various diseases including different cancers, suggesting possible avenue for exploring their etiologies based on N-glycomic analysis. Changes in N-glycan patterns during epithelial ovarian cancer development have so far been investigated mainly using serum, plasma, ascites, and cell lines. However, changes in patterns of N-glycans in tumor tissues during epithelial ovarian cancer progression have remained largely undefined. To investigate whether changes in N-glycan patterns correlate with oncogenesis and progression of epithelial ovarian cancer, we profiled N-glycans from formalin-fixed paraffin-embedded tissue slides using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and quantitatively compared among different pathological grades of epithelial ovarian cancer and healthy controls...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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