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Roi Treister, Mette Lodahl, Magdalena Lang, Shelley S Tworoger, Shlomo Sawilowsky, Anne Louise Oaklander
Small-fiber polyneuropathy (SFPN) affects unmyelinated and thinly myelinated peripheral axons. Several questionnaires have been developed to assess polyneuropathy from diabetes or chemotherapy, but none for SFPN from other or unknown causes. A comprehensive survey could help clinicians diagnose and assess treatment responses, define prevalence natural history and cures, and identify research subjects. Thus, we developed the 1-page Small-Fiber Symptom Survey, using input from patients and 21 medical/scientific experts...
May 2017: Journal of Pain: Official Journal of the American Pain Society
Anca Chiriac, Irina Costache, Cristian Podoleanu, Adrian Naznean, Simona Stolnicu
Bullosis diabeticorum (BD), or diabetic bulla, is 1 of the cutaneous manifestations of diabetes mellitus, reported in 0.5% of people with diabeties in the United States, mostly in adult men who have had long-lasting and uncontrolled diabetes associated with diabetic peripheral neuropathy. However, BD in young children is a mostly unrecognized entity. We present a case of BD in a 3-year-old girl with type 1 diabetes mellitus who had been treated with insulin for 7 months prior to hospitalization. Dermatologic examination revealed a large, tense bulla filled with clear fluid and not associated with pain or pruritus, localized on the lateral margin of the right hand...
April 2017: Canadian Journal of Diabetes
Mara Graziele Maciel Silveira, Antônio Carlos Sobral Sousa, Marcos Antônio Almeida Santos, Irlaneide da Silva Tavares, Stephanie Macedo Andrade, Luiza Dantas Melo, Loren Suyane Oliveira de Andrade, Emmanuel Lima Almeida Santos, Joselina Luzia Menezes Oliveira
BACKGROUND: Physical stress echocardiography is an established methodology for diagnosis and risk stratification of coronary artery disease in patients with physical capacity. In obese (body mass index ≥ 30 kg/m2) the usefulness of pharmacological stress echocardiography has been demonstrated; however, has not been reported the use of physical stress echocardiography in this growing population group. OBJECTIVE: To assess the frequency of myocardial ischemia in obese and non-obese patients undergoing physical stress echocardiography and compare their clinical and echocardiographic differences...
May 2015: Arquivos Brasileiros de Cardiologia
R K Vinod, M Shashikala, K P Suresh
The objectives of the study were to determine dyslipidaemia prevalence in first episode coronary heart disease cases and to determine the pattern of distribution of risk factors in this temporal relationship. This hospital based retrospective cohort study was conducted at Basaveshwara Teaching Hospital, Gulbarga, during January 2012. Data for the 3 year period (January 2005-December 2007) were collected from the case sheets of cardiac care unit admissions. Out of the 1,373 admissions to the cardiac care unit over the 36 months period, 462 case sheets were examined as these were the ones with first episode coronary heart disease aetiology...
June 2013: Journal of the Indian Medical Association
I K Quaye, L A Brakohiakpa, G A Amoah, N Ayi-Ankrah, Y Kido
Glycemic indices have been used to predict useful carbohydrate sources of food for patients with non-insulin-dependent diabeties mellitus (NIDDM) on dietary management programs. The present study has revealed that glycemic indices alone are not adequate predictors of useful carbohydrate meal sources. We observed for the first time that glycemic indexes inversely correlate with triglyceride indices. In our test mixed meals varying in five Ghanaian carbohydrate food types for nine non-insulin dependent diabetics, the correlation between glycemic and triglyceride indices was (r = -0...
March 1999: Asia Pacific Journal of Clinical Nutrition
P Fu, H Zhang, S M Siew, S Q Wang, A Xue, B H Hsu-Hage, M L Wahlqvist, Y F Wang, X X Li
This study investigated the food consumption patterns of 430 Beijing Chinese adults and assessed the impact on these patterns of the following socio-demographic characteristics: gender, age, educational achievement, and gross household income. Food intake by category, food variety and meal patterns were assessed using a 156-item food frequency questionnaire. It was found that gender and age were the most important factors to influence food consumption patterns. Men consumed more wheat products, red meat and tea, whereas women consumed more vegetables, fruit, nuts, fish, eggs and milk...
June 1998: Asia Pacific Journal of Clinical Nutrition
Knox Van Dyke, Erica Ghareeb, Robert Hoeldtke, Mark Van Dyke, Chris Van Dyke, David Van Thiel
Since oxidative/nitrosative stress cause diabetes, can we prevent this chemistry generating the disease? Streptozotocin causes diabetes by entering the pancreatic beta cell generating excessive nitric oxide which reacts with oxygen creating a toxin possibly peroxynitrite, dinitrogen trioxide, dinitrogen tetraoxide and so forth. The toxic compounds damage the DNA causing beta cell death. This prevents insulin synthesis, storage and release. By using antioxidant substances that destroy the nitric-oxide-based toxins (e...
2011: ISRN Toxicology
N Vador, Aarti G Jagtap, Archana Damle
Various studies have indicated that peptic ulcers occurring during the course of diabetic state are more severe and often associated with complications such as gastrointestinal bleeding. This study is the first attempt to understand the pathogenesis of gastric ulcers occurring during the diabetic state considering alternate biochemical pathways using suitable markers and its amelioration by Cuminum cyminum. In this study, diabetic rats showed a progressive increase in the stomach advanced glycated end products formation, gastric mucosal tumour necrosis factor-α and Thiobarbituric acid reactive substances levels as compared to normal control (nondiabetic) rats...
September 2012: Indian Journal of Pharmaceutical Sciences
Ayham Deeb, Salim Abou Jaoude, Mary Ann Winkle
SESSION TYPE: Sleep PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: To find out if the apnea link test (AL) is a reliable device for diagnosis or exclusion of OSA. To assess the correlation between AL and an overnight in-laboratory polysomnogram (PSG) performed at an accredited sleep laboratory, and to select a diagnostic apnea hypopnea index (AHI) cut off point on the AL that would reliably diagnose OSA.METHODS: We designed a prospective study that included patients who were hospitalized with a variety of conditions (Congestive heart failure, COPD, asthma exacerbation, diabeties and sepsis) between July 2009 and July 2011, who had a high clinical suspicion for OSA, and an AL performed during their hospitalization...
October 1, 2012: Chest
Hong Wang
OBJECTIVE: To investigate the effect of ophiopogon-polysaccharide on adiponectin (APN) in gestational diabetic mellitus rat. METHODS: The model of gestational diabetes mellitus rat were established with streptozotocin by intraperitoneal injection. Model rats were randomly divided into ophiopogon-polysaccharide 125 mg/kg group, 250 mg/kg group, 500 mg/kg group, GDM group and normal pregnancy group (n=10). Ophiopogon-polysaccharide was given by intragastric administration for 14 days...
April 13, 2013: Asian Pacific Journal of Tropical Medicine
A Ghosh, K Jana, K M Ali, D De, K Chatterjee, D Ghosh
The present study was conducted to explore the effect of ethyl acetate fraction of hydro-methanolic (40 : 60) extract of seed of Eugenia jambolana on testicular impairment in diabetic rats. In this respect, biomarkers of oxidative stress, genomics and proteomics in testicular tissue were assessed. Side by side, glycated haemoglobin, serum testosterone, activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in serum, epididymal sperm count including reproductive organosomatic indices were evaluated...
April 2014: Andrologia
Dingkun Gui, Jianhua Huang, Yongping Guo, Jianguo Chen, Yifang Chen, Wenzhen Xiao, Xusheng Liu, Niansong Wang
Accumulating evidence suggests that inflammatory processes are involved in the development of diabetic nephropathy (DN). However, there are no effective interventions for inflammation in the diabetic kidneys. Here, we tested the hypothesis that Astragaloside IV(AS-IV), a novel saponin purified from Astragalus membranaceus (Fisch) Bge, ameliorates DN in streptozotocin (STZ)-induced diabetic rats through anti-inflammatory mechanisms. Diabetes was induced with STZ (65 mg/kg) by intraperitoneal injection in rats...
March 2013: Cytokine
Samuele Baldasseroni, Alessandro Antenore, Claudia Di Serio, Francesco Orso, Giuseppe Lonetto, Nadia Bartoli, Alice Foschini, Andrea Marella, Alessandra Pratesi, Salvatore Scarantino, Stefano Fumagalli, Matteo Monami, Edoardo Mannucci, Niccolò Marchionni, Francesca Tarantini
BACKGROUND: Several peptides, named adipokines, are produced by the adipose tissue. Among those, adiponectin (AD) is the most abundant. AD promotes peripheral insulin sensitivity, inhibits liver gluconeogenesis and displays anti-atherogenic and anti-inflammatory properties. Lower levels of AD are related to a higher risk of myocardial infarction and a worse prognosis in patients with coronary artery disease. However, despite a favorable clinical profile, AD increases in relation to worsening heart failure (HF); in this context, higher adiponectinemia is reliably related to poor prognosis...
2012: Cardiovascular Diabetology
Carla W Sabandar, Norizan Ahmat, Faridahanim Mohd Jaafar, I Sahidin
The genus Jatropha (Euphorbiaceae) comprises of about 170 species of woody trees, shrubs, subshrubs or herbs in the seasonally dry tropics of the Old and the New World. They are used in medicinal folklore to cure various diseases of 80% of the human population in Africa, Asia and Latin America. Species from this genus have been popular to cure stomachache, toothache, swelling, inflammation, leprosy, dysentery, dyscrasia, vertigo, anemia, diabetis, as well as to treat HIV and tumor, opthalmia, ringworm, ulcers, malaria, skin diseases, bronchitis, asthma and as an aphrodisiac...
January 2013: Phytochemistry
Elisa Vega-Ávila, José Luis Cano-Velasco, Francisco J Alarcón-Aguilar, María Del Carmen Fajardo Ortíz, Julio César Almanza-Pérez, Rubén Román-Ramos
Introduction. Catharanthus roseus (L.) is used in some countries to treat diabetes. The aim of this study was to evaluate the hypoglycemic activity of extracts from the flower, leaf, stem, and root in normal and alloxan-induced diabetic mice. Methods. Roots, leaves, flowers, and stems were separated to obtain organic and aqueous extracts. The blood glucose lowering activity of these extracts was determinate in healthy and alloxan-induced (75 mg/Kg) diabetic mice, after intraperitoneal administration (250 mg/Kg body weight)...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
Hanan Munitz
Clozapine has been in use since 1975. It was withdrawn due to its toxic effects on granulocytes. It was reintroduced due to its positive effect on schizophrenia in patients who did not respond to two antipsychotic drugs. These patients suffer from a chronic debilitating disease, with numerous and sometimes chronic hospitalizations. Clozapine also has antiaggression and antisuicide effects, as well as specific effects on the negative symptoms of schizophrenia. There are severe side effects that may appear. These include suppression of granulocytes, cardiotoxic effect on the myocard, as well as cardiac conduction defects...
May 2012: Harefuah
Huilan Bao, Li Chen
OBJECTIVE: To investigate the effects of icariin on cardiac functions and mitochondrial oxidative stress in streptozotocin (STZ)-induced diabetic rats. METHOD: Male SD rats were randomly divided into normal control group, icariin control group, diabetic group, and diabetic groups administered with a low dose (30 mL x kg(-1) x d(-1), ig) or a high dose (120 mL x kg(-1) d(-1), ig) of icariin for 8 weeks. The body weight, blood glucose, cardiac functions, left ventricular weight, and myocardial collagen level were assayed...
June 2011: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Paula Claudina, Teresa Amaral, A Dinis da Gama
INTRODUCTION: Critical limb ischemia is a manifestation of peripheral arterial disease and in Portugal the profile of these patients is yet unknown as well as the frequency of hospital malnutrition. The present study aims to contribute to the updating of knowledge on the nutritional status of patients with this condition. AIM: To evaluate the frequency of malnutrition in hospitalized patients with critical lower limb ischemia. METHODOLOGY: A prospective longitudinal study was conducted in the University Clinic of Vascular Surgery of Hospital Santa Maria between November 2010 and February 2011...
October 2010: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Francesca Scarpini, Roberta Cappellone, Alberto Auteri, Luca Puccetti
Statins are relevant drugs involved in the reduction of cardiovascular events both in primary and secondary prevention. Related muscular side-effects are the most common cause of withdrawal and statins discontinuation could induce a negative rebound effect in terms of vascular events. Among factors in association with statins side-effects the combination with other drugs and the female sex are established conditions. However recent data suggest a specific genetic influence in intolerance development, at least for some statins...
September 2012: Cardiovascular & Hematological Disorders Drug Targets
Abiola O Oladapo, Jamie C Barner, Karen L Rascati, Scott A Strassels
BACKGROUND: Adherence to oral antidiabetic (OAD) medications is essential in achieving glycemic control and slowing the progression of diabeties-related complications such as neuropathic pain. OAD medication adherence has been suboptimal and adding neuropathic pain medications may negatively affect adherence. However, little is known about adherence to neuropathic pain medications by patients with diabetes and how this may be related to OAD medication adherence. OBJECTIVE: The objectives of our study were to: (1) describe painful diabetic peripheral neuropathy (PDPN) and OAD medication use, (2) determine if PDPN medication adherence differs among individual PDPN medications (ie, tricyclic antidepressants, gabapentin, pregabalin, and duloxetine); and (3) determine if PDPN medication adherence is related to post-index OAD medication adherence while controlling for covariates...
March 2012: Clinical Therapeutics
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