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https://www.readbyqxmd.com/read/28651084/treatment-of-food-waste-recycling-wastewater-using-anaerobic-ceramic-membrane-bioreactor-for-biogas-production-in-mainstream-treatment-process-of-domestic-wastewater
#1
Yeongmi Jeong, Slawomir W Hermanowicz, Chanhyuk Park
A bench-scale anaerobic membrane bioreactor (AnMBR) equipped with submerged flat-sheet ceramic membranes was operated at mesophilic conditions (30-35 °C) treating domestic wastewater (DWW) supplemented with food wasterecycling wastewater (FRW) to increase the organic loading rate (OLR) for better biogas production. Coupling ceramic membrane filtration with AnMBR treatment provides an alternative strategy for high organic wastewater treatment at short hydraulic retention times (HRTs) with the potential benefits of membrane fouling because they have a high hydrophilicity and more robust at extreme conditions...
June 19, 2017: Water Research
https://www.readbyqxmd.com/read/28650030/carbon-nanoscroll-silk-crystallite-hybrid-structures-with-controllable-hydration-and-mechanical-properties
#2
Yuan Cheng, Leng-Duei Koh, Fan Wang, Dechang Li, Baohua Ji, Jingjie Yeo, Guijian Guan, Ming-Yong Han, Yong-Wei Zhang
Hybrid structures of nanomaterials (e.g. tubes, scrolls, threads, cages) and biomaterials (e.g. proteins) hold tremendous potential for applications as drug carriers, biosensors, tissue scaffolds, cancer therapeutic agents, etc. However, in many cases, the interacting forces at the nano-bio interfaces and their roles in controlling the structures and dynamics of nano-bio-hybrid systems are very complicated but poorly understood. In this study, we investigate the structure and mechanical behavior of a protein-based hybrid structure, i...
June 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28648720/an-engineered-home-environment-for-untethered-data-telemetry-from-nonhuman-primates
#3
Marc P Powell, William R Britz, James S Harper Iii, David A Borton
BACKGROUND: Wireless neural recording technologies now provide untethered access to large populations of neurons in the nonhuman primate brain. Such technologies enable long-term, continuous interrogation of neural circuits and importantly open the door for chronic neurorehabilitation platforms. For example, by providing continuous consistent closed loop feedback from a brain machine interface, the nervous system can leverage plasticity to integrate more effectively into the system than would be possible in short experimental sessions...
June 22, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28646180/sustained-release-from-a-metal-analgesics-entrapped-within-biocidal-silver
#4
Barak Menagen, Rami Pedahzur, David Avnir
Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645511/lamellae-spatial-distribution-modulates-fracture-behavior-and-toughness-of-african-pangolin-scales
#5
Michael J Chon, Matthew Daly, Bin Wang, Xianghui Xiao, Alireza Zaheri, Marc A Meyers, Horacio D Espinosa
Pangolin scales form a durable armor whose hierarchical structure offers an avenue towards high performance bio-inspired materials design. In this study, the fracture resistance of African pangolin scales is examined using single edge crack three-point bend fracture testing in order to understand toughening mechanisms arising from the structures of natural mammalian armors. In these mechanical tests, the influence of material orientation and hydration level are examined. The fracture experiments reveal an exceptional fracture resistance due to crack deflection induced by the internal spatial orientation of lamellae...
June 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28644382/metal-ion-loaded-nanofibre-matrices-for-calcification-inhibition-in-polyurethane-implants
#6
Charanpreet Singh, Xungai Wang
Pathologic calcification leads to structural deterioration of implant materials via stiffening, stress cracking, and other structural disintegration mechanisms, and the effect can be critical for implants intended for long-term or permanent implantation. This study demonstrates the potential of using specific metal ions (MI)s for inhibiting pathological calcification in polyurethane (PU) implants. The hypothesis of using MIs as anti-calcification agents was based on the natural calcium-antagonist role of Mg(2+) ions in human body, and the anti-calcification effect of Fe(3+) ions in bio-prosthetic heart valves has previously been confirmed...
June 23, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28641542/functional-nanoparticles-and-their-interactions-with-mesenchymal-stem-cells
#7
Weiwei Wang, Zijun Deng, Xun Xu, Zhengdong Li, Friedrich Jung, Nan Ma, Andreas Lendlein
Mesenchymal stem cells (MSCs) have become one of the most important cell sources for regenerative medicine. However, some mechanisms of MSC-based therapy are still not fully understood. The clinical outcome may be restricted by some MSC-related obstacles such as the low survival rate, differentiation into undesired lineages and malignant transformation. In recent years, with the emergence of nanotechnology, various types of multifunctional nanoparticles (NPs) have been designed, prepared and explored for bio-related applications...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28641524/the-bio-psycho-social-dimension-in-women-s-sexual-desire-argumentum-ad-novitatem
#8
Nur Syazwani Roslan, Nik Ruzyanei Nik Jaafar, Hatta Sidi, Najwa Baharuddin, Jaya Kumar, Srijit Das, Nik Hazlina Nik Hussein
Sexual desire includes complex motivation and drive. In the context of biological and cognitive-emotive state art of science, it is often a neglected field in medicine. With regard to the treatment, study on women's sexual function received less attention compared to the men's sexuality. In the past, this endeavor was relatively not well disseminated in the scientific community. Recently, there was a revolutionized surge of drug targets available to treat women with low sexual desire. It is timely to review the relevant biological approach, especially in the context of pharmacotherapy to understand this interesting clinical entity which was modulated by numerous interactive psychosocial inter-play and factors...
June 21, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28640952/label-free-dynamic-mass-redistribution-and-bio-impedance-methods-for-drug-discovery
#9
Manuel Grundmann
Label-free biosensors are increasingly employed in drug discovery. Cell-based biosensors provide valuable insights into the biological consequences of exposing cells and tissues to chemical agents and the underlying molecular mechanisms associated with these effects. Optical biosensors based on the detection of dynamic mass redistribution (DMR) and impedance biosensors using cellular dielectric spectroscopy (CDS) capture changes of the cytoskeleton of living cells in real time. Because signal transduction correlates with changes in cell morphology, DMR and CDS biosensors are exquisitely suited for recording integrated cell responses in an unbiased, yet pathway-specific manner without the use of labels that may interfere with cell function...
June 22, 2017: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/28640580/a-bio-inspired-alginate-gum-arabic-hydrogel-with-micro-nano-scale-structures-for-controlled-drug-release-in-chronic-wound-healing
#10
Mi Li, Haichang Li, Xiangguang Li, Hua Zhu, Zihui Xu, Lianqing Liu, Jianjie Ma, Mingjun Zhang
Bio-polymeric hydrogels have drawn increasingly research interests in biomaterials due to its tunable physical and chemical properties for both creating bioactive cellular micro-environment and serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant for trapping insects, here we have developed a bio-inspired hydrogel to deliver mitsugumin53 (MG53), an important protein in cell membrane repair, for chronic wound healing. Both chemical compositions and micro/nano morphological properties inherent from the natural Sundew hydrogel were mimicked using sodium alginate and gum arabic with calcium ion-mediated cross-linking...
June 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28639437/ultrasound-assisted-green-economic-synthesis-of-hydroxyapatite-nanoparticles-using-eggshell-bio-waste-and-study-of-mechanical-and-biological-properties-for-orthopaedic-applications
#11
Vijay H Ingole, Kamal Hany Hussein, Anil A Kashale, Kalyani Ghule, Tomaž Vuherer, Vanja Kokol, Jia-Yaw Chang, Yong-Chien Ling, Aruna Vinchurkar, Hom N Dhakal, Anil V Ghule
Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic approach for the synthesis of nanocrystalline hydroxyapatite (Ca10 (PO4 )6 (OH)2 ) using recycled eggshell bio-waste referred as EHAp. The process involves the reaction of eggshell bio-waste as a source of calcium and ammonium dihydrogen orthophosphate as a phosphate source...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28634719/a-sugarcane-pathogenesis-related-protein-scpr10-plays-a-positive-role-in-defense-responses-under-sporisorium-scitamineum-srmv-sa-and-meja-stresses
#12
Qiong Peng, Yachun Su, Hui Ling, Waqar Ahmad, Shiwu Gao, Jinlong Guo, Youxiong Que, Liping Xu
A pathogenesis-related gene, ScPR10 , was isolated from sugarcane and its bio-function was characterized, demonstrating that ScPR10 was involved in plant defense responses to Sporisorium scitamineum , SrMV, SA, and MeJA stresses. Plant fungal and viral diseases are the major concerns in sugarcane industry. Many anti-fungal and antivirus components, including pathogenesis-related (PR) proteins, have been identified. The pathogenesis-related protein 10 (PR10) is the dominant group in PR families, involved in the plant defense mechanism...
June 20, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28633113/transformation-and-toxicity-assessment-of-two-uv-filters-using-uv-h2o2-process
#13
Mingguo Peng, Erdeng Du, Zhihong Li, Dongdong Li, Huajie Li
The treatment of two typical UV filters benzophenone-4 (BP4) and benzophenone-9 (BP9) was evaluated in aqueous solutions by UV/H2O2 process. High-resolution accurate mass spectrometry (HRMS) was used to identify the degradation intermediates. A total of 12 BP4 degradation products and 17 BP9 degradation products were identified. A series of OH-initiated reactions, including hydroxylation, dihydroxylation, decarboxylation, demethylation, and ring breaking, lead to the final mineralization of BP4 and BP9. The degradation mechanisms of BP4 and BP9 are also proposed, separately...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28630679/molecular-interactions-of-amyloid-nanofibrils-with-biological-aggregation-modifiers-implications-for-cytotoxicity-mechanisms-and-biomaterial-design
#14
REVIEW
Durga Dharmadana, Nicholas P Reynolds, Charlotte E Conn, Céline Valéry
Amyloid nanofibrils are ubiquitous biological protein fibrous aggregates, with a wide range of either toxic or beneficial activities that are relevant to human disease and normal biology. Protein amyloid fibrillization occurs via nucleated polymerization, through non-covalent interactions. As such, protein nanofibril formation is based on a complex interplay between kinetic and thermodynamic factors. The process entails metastable oligomeric species and a highly thermodynamically favoured end state. The kinetics, and the reaction pathway itself, can be influenced by third party moieties, either molecules or surfaces...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28630410/investigating-the-life-expectancy-and-proteolytic-degradation-of-engineered-skeletal-muscle-biological-machines
#15
Caroline Cvetkovic, Meghan C Ferrall-Fairbanks, Eunkyung Ko, Lauren Grant, Hyunjoon Kong, Manu O Platt, Rashid Bashir
A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, including fibrin, that provide physical support and cues to the cells as an engineered basement membrane. However, maintaining consistent results becomes challenging when sustaining a living system in vitro...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629074/tunable-green-graphene-silk-biomaterials-mechanism-of-protein-based-nanocomposites
#16
Fang Wang, S S Jyothirmayee Aravind, Hao Wu, Joseph Forys, Venkat Venkataraman, Kandalam Ramanujachary, Xiao Hu
Green graphene materials prepared by photoreduction of graphite oxide were first time blended with aqueous-based silk fibroin proteins to improve the mechanical and thermal properties of silk biomaterials, and their nanocomposite interaction mechanism was illustrated. Powder X-ray diffraction (XRD) analysis confirmed the complete exfoliation of graphite oxide to graphene in presence of focused pulses of solar radiation. By varying the concentration of graphene (0.1wt% to 10wt%), a series of free standing graphene-silk films were prepared and were systematically characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and nanoindentation measurements...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629012/equilibrium-kinetics-and-mechanism-of-au-3-pd-2-and-ag-ions-adsorption-from-aqueous-solutions-by-graphene-oxide-functionalized-persimmon-tannin
#17
Zhongmin Wang, Xiaojuan Li, Haijun Liang, Jingliang Ning, Zhide Zhou, Guiyin Li
In this study, a novel bio-adsorbent (PT-GO) was prepared by functionalization persimmon tannin (PT) with graphene oxide (GO) and the effective adsorption behaviors of Au(3+), Pd(2+) and Ag(+) ions from aqueous solution was investigated. The PT-GO was characterized by Fourier transform infrared spectrometer (FTIR), scanning electronic microscope (SEM), thermogravimetric analysis (TGA) and Zeta potential. Many influence factors such as pH value, bio-adsorbent dosage, initial concentration of metal ions and contact time were optimized...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628995/in-simulated-body-fluid-performance-of-polymorphic-apatite-coatings-synthesized-by-pulsed-electrodeposition
#18
Shoujie Liu, Hejun Li, Leilei Zhang, Xuemin Yin, Yao Guo
Surface modification is to modify biological responses through changing surface properties without reducing the mechanical properties of the implant. Specifically bioactive coatings, such as hydroxyapatite, carbonate apatite and dicalcium phosphate dehydrate, have been deposited on carbon/carbon (C/C) composites to change the bio-inert surface state. This work focused on the effects of voltages and electrolyte concentrations of pulsed electrodeposition on apatite layer. The apatite coatings thus synthesized were then structurally, morphologically and chemically characterized using X-ray diffraction, scanning electron microscopy, Transmission electron microscopy and Fourier-transform infrared spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627259/first-total-synthesis-of-a-novel-amide-alkaloid-derived-from-aconitum-taipeicum-and-its-anticancer-activity
#19
Xinxin Zhang, Dandan Li, Xuanji Xue, Yan Zhang, Jie Zhang, Chen Huang, Zengjun Guo, Nigatu Tadesse
A concise total synthesis of a naturally occurring 3-isopropyl-tetrahydropyrrolo[1, 2-a]pyrimidine-2, 4(1H, 3H)-dione (ITPD) isolated from Aconitum taipeicum with a three-step approach was depicted in this study for the first time. Two key intermediates, diethyl isopropylmalonate (2) and pyrrolidin-2-amine (3), being synthsesised separately from initial diethyl malonate (4) and 3, 4-dihydro-2H-pyrrol-5-amine (5), were utilised to obtain the compound entitled ITPD. ITPD showed a promising anticancer activity in vitro on SMMC-7721 cell lines...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28626450/microbial-phosphorus-solubilization-and-its-potential-for-use-in-sustainable-agriculture
#20
REVIEW
Elizabeth T Alori, Bernard R Glick, Olubukola O Babalola
The use of excess conventional Phosphorus (P) fertilizers to improve agricultural productivity, in order to meet constantly increasing global food demand, potentially causes surface and ground water pollution, waterway eutrophication, soil fertility depletion, and accumulation of toxic elements such as high concentration of selenium (Se), arsenic (As) in the soil. Quite a number of soil microorganisms are capable of solubilizing/mineralizing insoluble soil phosphate to release soluble P and making it available to plants...
2017: Frontiers in Microbiology
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