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https://www.readbyqxmd.com/read/28213660/evidence-of-an-unidentified-extracellular-heat-stable-factor-produced-by-lysobacter-enzymogenes-oh11-that-degrade-fusarium-graminearum-ph1-hyphae
#1
Benard Omondi Odhiambo, Gaoge Xu, Guoliang Qian, Fengquan Liu
Lysobacter enzymogenes OH11 produces heat-stable antifungal factor (HSAF) and lytic enzymes possessing antifungal activity. This study bio-prospected for other potential antifungal factors besides those above. The cells and extracellular metabolites of L. enzymogenes OH11 and the mutants ΔchiA, ΔchiB, ΔchiC, Δclp, Δpks, and ΔpilA were examined for antifungal activity against Fusarium graminearum PH1, the causal agent of Fusarium head blight (FHB). Results evidenced that OH11 produces an unidentified extracellular heat-stable degrading metabolite (HSDM) that exhibit degrading activity on F...
February 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28211801/effect-of-shear-induced-platelet-activation-on-red-blood-cell-aggregation
#2
Hoyoon Lee, Kisung Lee, Byoung-Kwon Lee, Alexander V Priezzhev, Sehyun Shin
Mechanical shear stress is one of the important factors for platelet activation. Although shear stress has been frequently utilized in many applications of diagnostic bio-equipment, there has been little consideration as to whether shear stress induces platelet activation and consequently alters hemorheological characteristics. Therefore, we investigated the effect of shear-induced platelet activation on red blood cell (RBC) aggregation. The hypothesis of the present research is as follows: Platelets activated by high shear stress secrete substances, which can affect hemorheological characteristics to promote RBC aggregation...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28211362/marrow-isolated-adult-multilineage-inducible-cells-embedded-within-a-biologically-inspired-construct-promote-recovery-in-a-mouse-model-of-peripheral-vascular-disease
#3
Cristina Grau-Monge, Gaëtan J-R Delcroix, Andrea Bonnin-Marquez, Mike Valdes, Ead Lewis Mazen Awadallah, Daniel F Quevedo, Maxime R Armour, Ramon B Montero, Paul C Schiller, Fotios M Andreopoulos, Gianluca D'Ippolito
Peripheral vascular disease is one of the major vascular complications in individuals suffering from diabetes and in the elderly that is associated with significant burden in terms of morbidity and mortality. Stem cell therapy is being tested as an attractive alternative to traditional surgery to prevent and treat this disorder. The goal of this study was to enhance the protective and reparative potential of marrow-isolated adult multilineage inducible (MIAMI) cells by incorporating them within a bio-inspired construct (BIC) made of two layers of gelatin B electrospun nanofibers...
February 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28204831/tachycardia-bradycardia-syndrome-electrophysiological-mechanisms-and-future-therapeutic-approaches-review
#4
Gary Tse, Tong Liu, Ka Hou Christien Li, Victoria Laxton, Andy On-Tik Wong, Yin Wah Fiona Chan, Wendy Keung, Camie W Y Chan, Ronald A Li
Sick sinus syndrome (SSS) encompasses a group of disorders whereby the heart is unable to perform its pacemaker function, due to genetic and acquired causes. Tachycardia‑bradycardia syndrome (TBS) is a complication of SSS characterized by alternating tachycardia and bradycardia. Techniques such as genetic screening and molecular diagnostics together with the use of pre-clinical models have elucidated the electrophysiological mechanisms of this condition. Dysfunction of ion channels responsible for initiation or conduction of cardiac action potentials may underlie both bradycardia and tachycardia; bradycardia can also increase the risk of tachycardia, and vice versa...
February 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28202024/who-cone-bio-assays-of-classical-and-new-generation-long-lasting-insecticidal-nets-call-for-innovative-insecticides-targeting-the-knock-down-resistance-mechanism-in-benin
#5
Marius Allossogbe, Virgile Gnanguenon, Boulais Yovogan, Bruno Akinro, Rodrigue Anagonou, Fiacre Agossa, André Houtoukpe, Germain Gil Padonou, Martin Akogbeto
BACKGROUND: To increase the effectiveness of insecticide-treated nets (ITN) in areas of high resistance, new long-lasting insecticidal nets (LLINs) called new-generation nets have been developed. These nets are treated with the piperonyl butoxide (PBO) synergist which inhibit the action of detoxification enzymes. The effectiveness of the new-generation nets has been proven in some studies, but their specific effect on mosquitoes carrying detoxification enzymes and those carrying both detoxification enzymes and the knock-down resistance gene in Benin is not well known...
February 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28196415/hierarchical-assembly-of-tough-bioelastomeric-egg-capsules-is-mediated-by-a-bundling-protein
#6
Jun Jie Loke, Akshita Kumar, Shawn Hoon, Chandra S Verma, Ali Miserez
Marine snail egg capsules are shock-absorbing bio-elastomers made from precursor "egg case proteins" (ECPs) that initially lack long-range order. During capsule formation, these proteins self-assemble into coiled-coil filaments that subsequently align into microscopic layers, a multi-scale process which is crucial to the capsules' shock-absorbing properties. In this study, we show that the self-assembly of ECPs into their functional capsule material is mediated by a bundling protein that facilitates the aggregation of coiled-coil building blocks and their gelation into a pre-final capsule prior to final stabilization...
February 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28194238/epigenome-wide-association-study-ewas-on-lipids-the-rotterdam-study
#7
Kim V E Braun, Klodian Dhana, Paul S de Vries, Trudy Voortman, Joyce B J van Meurs, Andre G Uitterlinden, Albert Hofman, Frank B Hu, Oscar H Franco, Abbas Dehghan
BACKGROUND: DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol in 725 participants of the Rotterdam Study, a population-based cohort study. Subsequently, we sought replication in a non-overlapping set of 760 participants...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28193541/a-nano-scaled-and-multi-layered-recombinant-fibronectin-cadherin-chimera-composite-selectively-concentrates-osteogenesis-related-cells-and-factors-to-aid-bone-repair
#8
Junchao Xing, Tieniu Mei, Keyu Luo, Zhiqiang Li, Aijun Yang, Zhilin Li, Zhao Xie, Zehua Zhang, Shiwu Dong, Tianyong Hou, Jianzhong Xu, Fei Luo
: Easily accessible and effective bone grafts are in urgent need in clinic. The selective cell retention (SCR) strategy, by which osteogenesis-related cells and factors are enriched from bone marrow into bio-scaffolds, holds great promise. However, the retention efficacy is limited by the relatively low densities of osteogenesis-related cells and factors in marrow; in addition, a lack of satisfactory surface modifiers for scaffolds further exacerbates the dilemma. To address this issue, a multi-layered construct consisting of a recombinant fibronectin/cadherin chimera was established via a layer-by-layer self-assembly technique (LBL-rFN/CDH) and used to modify demineralised bone matrix (DBM) scaffolds...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28193207/a-novel-point-mutation-in-rpob-improves-osmotolerance-and-succinic-acid-production-in-escherichia-coli
#9
Mengyong Xiao, Xinna Zhu, Hongtao Xu, Jinlei Tang, Ru Liu, Changhao Bi, Feiyu Fan, Xueli Zhang
BACKGROUND: Escherichia coli suffer from osmotic stress during succinic acid (SA) production, which reduces the performance of this microbial factory. RESULTS: Here, we report that a point mutation leading to a single amino acid change (D654Y) within the β-subunit of DNA-dependent RNA polymerase (RpoB) significantly improved the osmotolerance of E. coli. Importation of the D654Y mutation of RpoB into the parental strain, Suc-T110, increased cell growth and SA production by more than 40% compared to that of the control under high glucose osmolality...
February 13, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28193060/-bio-sensing-using-nanoparticle-arrays-on-the-effect-of-analyte-transport-on-sensitivity
#10
N Scott Lynn, Jiří Homola
There has recently been an extensive amount of work regarding the development of optical, electrical, and mechanical (bio)sensors employing planar arrays of surface-bound nanoparticles. The sensor output for these systems is dependent on the rate at which analyte is transported to, and interacts with, each nanoparticle in the array. There has so far been little discussion on the relationship between the design parameters of an array and the interplay of convection, diffusion, and reaction. Moreover, current methods providing such information require extensive computational simulation...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191922/synergistic-integration-of-experimental-and-simulation-approaches-for-the-de-novo-design-of-silk-based-materials
#11
Wenwen Huang, Davoud Ebrahimi, Nina Dinjaski, Anna Tarakanova, Markus J Buehler, Joyce Y Wong, David L Kaplan
Tailored biomaterials with tunable functional properties are crucial for a variety of task-specific applications ranging from healthcare to sustainable, novel bio-nanodevices. To generate polymeric materials with predictive functional outcomes, exploiting designs from nature while morphing them toward non-natural systems offers an important strategy. Silks are Nature's building blocks and are produced by arthropods for a variety of uses that are essential for their survival. Due to the genetic control of encoded protein sequence, mechanical properties, biocompatibility, and biodegradability, silk proteins have been selected as prototype models to emulate for the tunable designs of biomaterial systems...
February 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28187320/mechanical-and-biological-behavior-of-ultrafine-grained-ti-alloy-aneurysm-clip-processed-using-high-pressure-torsion
#12
Ho Yong Um, Byung Ho Park, Dong-Hyun Ahn, Mohamed Ibrahim Abd El Aal, Jaechan Park, Hyoung Seop Kim
Severe plastic deformation (SPD) has recently been advanced as the main process for fabricating bulk ultrafine grained or nanocrystalline metallic materials, which present much higher strength and better bio-compatibility than coarse-grained counterparts. Medical devices, such as aneurysm clips and dental implants, require high mechanical and biological performance (e.g., stiffness, yield strength, fatigue resistance, and bio-compatibility). These requirements match well the characteristics of SPD-processed materials...
February 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28186709/in-vitro-evaluation-of-the-biological-compatibility-and-antibacterial-activity-of-a-bone-substitute-material-consisting-of-silver-doped-hydroxyapatite-and-bio-oss-%C3%A2
#13
Jingjue Gong, Lei Yang, Qi He, Ting Jiao
This study evaluated biological compatibility and antibacterial activity of a bone substitute material consisting of silver-doped hydroxyapatite (AgHA) and Bio-Oss(®) with different mixture ratios in vitro and investigated its antibacterial mechanism. AgHA was synthesized by a chemical precipitation method. After characterization, AgHA was mixed with Bio-Oss(®) at three ratios: 1:1, 1:2, and 1:4 by weight. Then, Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were used to test the antibacterial activity of the mixture...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28186214/monodisperse-phase-transfer-and-surface-bioengineering-of-metal-nanoparticles-via-a-silk-fibroin-protein-corona
#14
Xiao-Wei Huang, Hong Liang, Zhi Li, Jie Zhou, Xian Chen, Shu-Meng Bai, Huang-Hao Yang
Uniform hydrophobic nanoparticles synthesized in nonpolar solvents possess excellent physio-chemical properties, showing great potential in biomedical applications. However, the presence of hydrophobic ligands on their surfaces limits their use under physiological conditions. Inspired by protein coronas present at the nano-bio interface, here we report a facile and universal method for phase transfer and surface bioengineering of hydrophobic nanoparticles using β-sheet-rich silk fibroin, a FDA-approved natural protein...
February 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28186124/algal-cell-response-to-pulsed-waved-stimulation-and-its-application-to-increase-algal-lipid-production
#15
Oleksandra Savchenko, Jida Xing, Xiaoyan Yang, Quanrong Gu, Mohamed Shaheen, Min Huang, Xiaojian Yu, Robert Burrell, Prabir Patra, Jie Chen
Generating renewable energy while sequestering CO2 using algae has recently attracted significant research attention, mostly directing towards biological methods such as systems biology, genetic engineering and bio-refining for optimizing algae strains. Other approaches focus on chemical screening to adjust culture conditions or culture media. We report for the first time the physiological changes of algal cells in response to a novel form of mechanical stimulation, or a pulsed wave at the frequency of 1.5 MHz and the duty cycle of 20%...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183649/biological-and-mechanical-evaluation-of-a-bio-hybrid-scaffold-for-autologous-valve-tissue-engineering
#16
S Jahnavi, U Saravanan, N Arthi, G S Bhuvaneshwar, T V Kumary, S Rajan, R S Verma
Major challenge in heart valve tissue engineering for paediatric patients is the development of an autologous valve with regenerative capacity. Hybrid tissue engineering approach is recently gaining popularity to design scaffolds with desired biological and mechanical properties that can remodel post implantation. In this study, we fabricated aligned nanofibrous Bio-Hybrid scaffold made of decellularized bovine pericardium: polycaprolactone-chitosan with optimized polymer thickness to yield the desired biological and mechanical properties...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183073/melkersson-rosenthal-syndrome-a-case-report-with-a-psychosomatic-perspective
#17
Patrick Alves, Orlando von Doellinger, Maria Luísa Quintela, Aníbal Fonte, Rui Coelho
Context • The Melkersson-Rosenthal syndrome (MRS) is a rare condition characterized by a triad of symptoms: (1) recurrent and/or persistent orofacial swelling, (2) recurrent facial paralysis, and (3) a fissured tongue. Although various contributing factors have been suggested, the etiology and mechanisms of the syndrome have not been fully elucidated. Objective • The aim of the current study was to examine for the first time some psychosomatic aspects of the syndrome and to evaluate the benefits of a brief psychotherapeutic process in which the research team worked to reintegrate the complex bio-psycho-social functioning of the patient...
January 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28183018/multifold-enhanced-synergistic-removal-of-nickel-and-phosphate-by-a-n-fe-dual-functional-bio-sorbent-mechanism-and-application
#18
Yan-Hong Zhang, Fu-Qiang Liu, Chang-Qing Zhu, Xiao-Peng Zhang, Meng-Meng Wei, Feng-He Wang, Chen Ling, Ai-Min Li
A novel (N,Fe)-dual-functional biosorbent (N/Fe-DB) capable of efficient synergistic removal of Ni(II) and H2PO4(-) from aqueous solution was synthesized. The adsorption capacities of Ni(II) and H2PO4(-) were both remarkably enhanced over 3 times compared with those in single systems. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed that complexation of amino groups and ligand exchange of hydrous ferric oxide in N/Fe-DB played dominant roles. The electric double layer compressing and chelating ligand of deprotonated H2PO4(-) accounted for the enhanced removal of Ni(II) in binary system, while cation bridge interaction promoted uptake of H2PO4(-)...
January 31, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28179013/reac-technology-as-optimizer-of-stallion-spermatozoa-liquid-storage
#19
Fiammetta Berlinguer, Valeria Pasciu, Sara Succu, Ignazio Cossu, Sabrina Caggiu, Daniela Addis, Alessandro Castagna, Vania Fontani, Salvatore Rinaldi, Eraldo Sanna Passino
BACKGROUND: REAC technology (acronym for Radio Electric Asymmetric Conveyor) is a technology platform for neuro and bio modulation. It has already proven to optimize the ions fluxes at the molecular level and the molecular mechanisms driving cellular asymmetry and polarization. METHODS: This study was designed to verify whether this technology could extend spermatozoa life-span during liquid storage, while preserving their functions, DNA integrity and oxidative status...
February 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28178887/magnesium-presence-prevents-removal-of-antigenic-nuclear-associated-proteins-from-bovine-pericardium-for-heart-valve-engineering
#20
Ailsa Dalgliesh, Zhi Zhao Liu, Leigh Griffiths
Current heart valve prostheses are associated with significant complications including aggressive immune response, limited valve life expectancy, and inability to grow in juvenile patients. Animal derived "tissue" valves undergo glutaraldehyde fixation to mask tissue antigenicity, however chronic immunological responses and associated calcification still commonly occur. A heart valve formed from an unfixed bovine pericardium (BP) extracellular matrix (ECM) scaffold, in which antigenic burden has been eliminated or significantly reduced, has potential to overcome deficiencies of current bio-prostheses...
February 8, 2017: Tissue Engineering. Part A
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