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https://www.readbyqxmd.com/read/28823079/mechanobiological-model-of-arterial-growth-and-remodeling
#1
Maziyar Keshavarzian, Clark A Meyer, Heather N Hayenga
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure...
August 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28818729/characterization-of-citrus-pectin-films-integrated-with-clove-bud-essential-oil-physical-thermal-barrier-antioxidant-and-antibacterial-properties
#2
Tanzeela Nisar, Zi-Chao Wang, Xi Yang, You Tian, Muneeb Iqbal, Yurong Guo
The increasing demand for bio-based materials to be used in food packaging has stimulated the development of novel, environmentally-friendly edible films. Antimicrobial films were developed by incorporating different levels of clove bud essential oil (0.5%, 1.0%, and 1.5%) into the citrus pectin in order to modify the functional properties of the films. Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry analysis (DSC) and X-ray diffraction (XRD) were performed, together with the determination of physical, optical, mechanical, antioxidant and antimicrobial properties of pectin emulsified films...
August 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28815910/streptococcus-pneumoniae-surface-protein-pfba-is-a-versatile-multi-domain-and-multi-ligand-binding-adhesin-employing-different-binding-mechanisms
#3
D S Jemima Beulin, Deepthi Radhakrishnan, C S Sharanya, Chittalakottu Sadasivan, Masaya Yamaguchi, Shigetada Kawabata, Karthe Ponnuraj
Streptococcus pneumoniae, one of the major human respiratory pathogens, uses its repertoire of surface proteins to adhere to the epithelium of the nasopharynx and lungs leading to colonization. PfbA is a conserved surface protein of S. pneumoniae and helps the bacterium to colonize the host by recognizing the extracellular matrix (ECM) molecule fibronectin, as well as blood proteins like plasminogen and human serum albumin. The crystal structure of rPfbA150-607 revealed it to possess a beta helical region similar to those of carbohydrate-active enzymes as well as a C-terminal segment that resembles the fibronectin-binding regions of fibronectin-binding proteins...
August 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28815775/pet-switching-mechanism-of-a-napthalimide-derivative-with-its-solvatochromic-behaviour-an-experimental-and-theoretical-study-with-in-cell-investigations
#4
Dipti Singharoy, Sourav Chowdhury, Soumya Sundar Mati, Swadesh Ghosh, Krishnananda Chattopadhyay, Subhash Chandra Bhattacharya
The sole existence of t-bone shape napthalimide derivative [2-(2-aminoethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione] (NAP) which in turn gives rise to a PET mechanism, has been established using a combination of experimental and theoretical studies. In parallel an in vitro-in cell PET mechanism has also been shown. To understand the photo physics of NAP, solvent studies have been carried out in different solvents. In addition, theoretical calculations have been resorted to explain the spectroscopic properties through optimized structures...
August 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815412/study-of-the-removal-mechanism-of-aquatic-emergent-pollutants-by-new-bio-based-chars
#5
Maria Manuel Serrano Bernardo, Catarina Alexandra Catanas Madeira, Nuno Carlos Lapa Dos Santos Nunes, Diogo André Costa Messias Dias, Delfina Maria Barbosa Godinho, Maria Filomena de Jesus Pinto, Inês Alexandra Morgado do Nascimento Matos, Ana Paula Batista Carvalho, Isabel Maria de Figueiredo Ligeiro Fonseca
This work is dedicated to study the potential application of char byproducts obtained in the gasification of rice husk (RG char) and rice husk blended with corn cob (RCG char) as removal agents of two emergent aquatic contaminants: tetracycline and caffeine. The chars presented high ash contents (59.5-81.5%), being their mineral content mainly composed of silicon (as silica) and potassium. The samples presented a strong basic character, which was related to its higher mineral oxides content. RCG char presented better textural properties with a higher apparent surface area (144 m(2) g(-1)) and higher micropore content (V micro = 0...
August 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28815398/characterization-of-host-response-resorption-and-strength-properties-and-performance-in-the-presence-of-bacteria-for-fully-absorbable-biomaterials-for-soft-tissue-repair
#6
N F N Stoikes, J R Scott, A Badhwar, C R Deeken, G R Voeller
PURPOSE: The objective was to evaluate the host response, resorption, and strength properties, and to assess the performance in the presence of bacteria for Phasix™ Mesh (Phasix™) and Gore(®) Bio-A(®) Tissue Reinforcement (Bio-A(®)) in preclinical models. METHODS: In a rat model, one mesh (2 × 2 cm) was implanted subcutaneously in n = 60 rats. Animals were euthanized after 2, 4, 8, 12, 16, or 24 weeks (n = 5/mesh/time point), and implant sites were assessed for host inflammatory response and overall fibrotic repair thickness...
August 16, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28814027/challenges-in-using-compliant-ligaments-for-position-estimation-within-robotic-joints
#7
Felix Russell, Lei Gao, Peter Ellison, Ravi Vaidyanathan
The mechanical advantages of bio-inspired condylar robotic knee joints for use in prosthetics or rehabilitation has been argued extensively in literature. A common limitation of these designs is the difficulty of estimating joint angle and therefore accurately controlling the joint. Furthermore, the potential role of ligament-like structures in robotic knees is not very well established. In this work, we investigate the role of compliant stretch sensing ligaments and their integration into a condylar robotic knee...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811206/production-and-physicochemical-properties-of-carboxymethyl-cellulose-films-enriched-with-spent-coffee-grounds-polysaccharides
#8
Lina F Ballesteros, Miguel A Cerqueira, José A Teixeira, Solange I Mussatto
Extracts rich in polysaccharides were obtained by alkali pretreatment (PA) or autohydrolysis (PB) of spent coffee grounds, and incorporated into a carboxymethyl cellulose (CMC)-based film aiming at the development of bio-based films with new functionalities. Different concentrations of PA or PB (up to 0.20% w/v) were added to the CMC-based film and the physicochemical properties of the final films were determined. Scanning electronic microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, as well as determinations of optical and mechanical properties, moisture content, solubility, water vapor permeability, contact angle and sorption isotherms were performed...
August 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28810222/bio-electro-oxidation-of-indigo-carmine-by-using-microporous-activated-carbon-fiber-felt-as-anode-and-bioreactor-support
#9
Luane Ferreira Garcia, Ana Claudia Rodrigues Siqueira, Germán Sanz Lobón, Jossano Saldanha Marcuzzo, Benevides Costa Pessela, Eduardo Mendez, Telma Alves Garcia, Eric de Souza Gil
The bioremediation and electro-oxidation (EO) processes are included among the most promising cleaning and decontamination mechanisms of water. The efficiency of bioremediation is dictated by the biological actuator for a specific substrate, its suitable immobilization and all involved biochemical concepts. The EO performance is defined by the anode efficiency to perform the complete mineralization of target compounds and is highlighted by the low or null use of reagent. Recently, the combination of both technologies has been proposed...
August 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28810203/chemical-activity-and-distribution-of-emerging-pollutants-insights-from-a-multi-compartment-analysis-of-a-freshwater-system
#10
Pedro A Inostroza, Riccardo Massei, Romy Wild, Martin Krauss, Werner Brack
Emerging pollutants are ubiquitous in the aquatic system and may pose risks to aquatic ecosystems. The quantification and prediction of environmental partitioning of these chemicals in aquatic systems between water, sediment and biota is an important step in the comprehensive assessment of their sources and final fates in the environment. In this multi-compartment field study, we applied equilibrium partitioning theory and chemical activity estimates to investigate the predictability of concentrations in Gammarus pulex as a model invertebrate from water and sediment in a typical small central European river...
August 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28807882/control-of-nucleus-positioning-in-mouse-oocytes
#11
REVIEW
Maria Almonacid, Marie-Emilie Terret, Marie-Hélène Verlhac
The position of the nucleus in a cell can instruct morphogenesis in some cases, conveying spatial and temporal information and abnormal nuclear positioning can lead to disease. In oocytes from worm, sea urchin, frog and some fish, nucleus position regulates embryo development, it marks the animal pole and in Drosophila it defines the future dorso-ventral axis of the embryo and of the adult body plan. However, in mammals, the oocyte nucleus is centrally located and does not instruct any future embryo axis. Yet an off-centre nucleus correlates with poor outcome for mouse and human oocyte development...
August 11, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28802218/pharmaceutical-and-biomedical-applications-of-dispersive-liquid-liquid-microextraction
#12
REVIEW
Fotouh R Mansour, Mostafa A Khairy
Sample treatment is so crucial in pharmaceutical and biomedical analysis. Proper sample preparation protects the analytical instrument, increases the sensitivity, and enhances the selectivity by removing probable interfering substances. Dispersive liquid-liquid microextraction (DLLME) is one of the most important approaches in sample treatment. In normal DLLME, the organic droplet of the extractant is mixed with a dispersing solvent before being injected into the sample. After manual or mechanical shaking, the cloudy solution is centrifuged to break the formed emulsion...
August 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28802167/induction-of-senescence-in-cancer-cells-by-5-aza-2-deoxycytidine-bioinformatics-and-experimental-insights-to-its-targets
#13
Jayarani F Putri, Nashi Widodo, Kazuichi Sakamoto, Sunil C Kaul, Renu Wadhwa
5'-Aza-2'-deoxycytidine (5-Aza-dC) is a demethylating drug that causes genome-wide hypomethylation resulting in the expression of several tumor suppressor genes causing growth arrest of cancer cells. Cancer is well established as a multifactorial disease and requires multi-module therapeutics. Search for new drugs and their approval by FDA takes a long time. Keeping this in view, research on new functions of FDA-approved anticancer drugs is desired to expand the list of multi-module functioning drugs for cancer therapy...
August 2, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28801920/restoration-of-thalamo-cortical-connectivity-after-brain-injury-recovery-of-consciousness-complex-behavior-or-passage-of-time
#14
Julia S Crone, Branden J Bio, Paul M Vespa, Evan S Lutkenhoff, Martin M Monti
In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to the return of complex cognitive function in general or simply the temporal evolution of post-injury pathophysiological events. To test whether the restoration of thalamo-cortical connectivity is specific to consciousness, 20 moderate-to-severe brain injury patients (from a recruited sample of 42) underwent resting-state functional magnetic resonance imaging within a week after injury and again six months later...
August 12, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28801795/storage-lipid-and-polysaccharide-metabolism-in-yarrowia-lipolytica-and-umbelopsis-isabellina
#15
Marianna Dourou, Panagiotis Mizerakis, Seraphim Papanikolaou, George Aggelis
Complex biochemical mechanisms are being involved in oleaginous microorganisms during storage lipid and polysaccharide metabolism. Detailed biochemical analyses and monitoring of key enzymes involved in carbon metabolism were performed in Yarrowia lipolytica and Umbelopsis isabellina, which are often used as model oleaginous microorganisms. It was found that during the early oleaginous phase, the carbon source (glucose) was channeled to lipid accumulation, but also to polysaccharide biosynthesis. However, during transition from the early to the late oleaginous phase, glucose was exclusively converted to lipids, while in U...
August 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28801640/spectroscopic-observation-of-oxygen-dissociation-on-nitrogen-doped-graphene
#16
Mattia Scardamaglia, Toma Susi, Claudia Struzzi, Rony Snyders, Giovanni Di Santo, Luca Petaccia, Carla Bittencourt
Carbon nanomaterials' reactivity towards oxygen is very poor, limiting their potential applications. However, nitrogen doping is an established way to introduce active sites that facilitate interaction with gases. This boosts the materials' reactivity for bio-/gas sensing and enhances their catalytic performance for the oxygen reduction reaction. Despite this interest, the role of differently bonded nitrogen dopants in the interaction with oxygen is obscured by experimental challenges and has so far resisted clear conclusions...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799760/biomolecular-structure-information-from-high-speed-quantum-mechanical-electronic-spectra-calculation
#17
Jakob Seibert, Christoph Bannwarth, Stefan Grimme
A fully quantum mechanical (QM) treatment to calculate electronic absorption (UV-Vis) and circular dichroism (CD) spectra of typical biomolecules with thousands of atoms is presented. With our highly efficient sTDA-xTB method, spectra averaged along structures from molecular dynamics (MD) simulations can be computed in a reasonable time frame on standard desktop computers. This way, non-equilibrium structure and conformational as well as purely quantum mechanical effects like charge-transfer or exciton-coupling are included...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28799741/early-assessment-and-correlations-of-nanoclay-s-toxicity-to-their-physical-and-chemical-properties
#18
Alixandra Wagner, Andrew White, Todd A Stueckle, Derrick Banerjee, Konstantinos A Sierros, Yon Rojanasakul, Sushant Agarwal, Rakesh K Gupta, Cerasela Zoica Dinu
Nanoclays' functionalization with organic modifiers increases their individual barrier properties, thermal stability, and mechanical properties and allows for ease of implementation in food packaging materials or medical devices. Previous reports have showed that while organic modifiers integration between the layered mineral silicates leads to nanoclays with different degrees of hydrophobicity that become easily miscible in polymers, they could also pose possible effects at inhalation or ingestion routes of exposure...
August 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28799341/polyaspartic-acid-facilitates-oxolation-within-iron-iii-oxide-pre-nucleation-clusters-and-drives-the-formation-of-organic-inorganic-composites
#19
J Scheck, M Drechsler, X Ma, M T Stöckl, J Konsek, J B Schwaderer, S M Stadler, J J De Yoreo, D Gebauer
The interplay between polymers and inorganic minerals during the formation of solids is crucial for biomineralization and bio-inspired materials, and advanced material properties can be achieved with organic-inorganic composites. By studying the reaction mechanisms, basic questions on organic-inorganic interactions and their role during material formation can be answered, enabling more target-oriented strategies in future synthetic approaches. Here, we present a comprehensive study on the hydrolysis of iron(iii) in the presence of polyaspartic acid...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28798358/small-amphipathic-peptides-are-responsible-for-the-assembly-of-cruciferin-nanoparticles
#20
Hui Hong, Ali Akbari, Jianping Wu
Amphipathic peptides are versatile building blocks for fabricating well-ordered nanostructures, which have gained much attention owing to their enormous design possibilities and bio-functionalities. However, using amphipathic peptides from natural proteins to create tunable nanostructures is challenging because of their heterogeneity and great tendency to form aggregates. Here we fabricated two well-defined nanoparticles from cruciferin amphipathic peptides by integrating top-down and bottom-up approach. Alkali hydrolysis (pH 12, 120 °C for 30 min) was introduced to break down intact cruciferin into peptides (top-down)...
August 10, 2017: Scientific Reports
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