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https://www.readbyqxmd.com/read/28110507/computer-assisted-quantification-of-cd3-t-cells-in-follicular-lymphoma
#1
Fazly S Abas, Arwa Shana'ah, Beth Christian, Robert Hasserjian, Abner Louissaint, Michael Pennell, Berkman Sahiner, Weijie Chen, Muhammad Khalid Khan Niazi, Gerard Lozanski, Metin Gurcan
The advance of high resolution digital scans of pathology slides allowed development of computer based image analysis algorithms that may help pathologists in IHC stains quantification. While very promising, these methods require further refinement before they are implemented in routine clinical setting. Particularly critical is to evaluate algorithm performance in a setting similar to current clinical practice. In this article, we present a pilot study that evaluates the use of a computerized cell quantification method in the clinical estimation of CD3 positive (CD3+) T cells in follicular lymphoma (FL)...
January 22, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28110367/accurate-simultaneous-quantification-of-liver-steatosis-and-iron-overload-in-diffuse-liver-diseases-with-mri
#2
Manuela França, Ángel Alberich-Bayarri, Luis Martí-Bonmatí, Pedro Oliveira, Francisca Emanuel Costa, Graça Porto, José Ramón Vizcaíno, Javier Sanchez Gonzalez, Eduardo Ribeiro, João Oliveira, Helena Pessegueiro Miranda
PURPOSE: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload in a wide spectrum of diffuse liver diseases having biopsy as reference standard. METHODS: MECSE-MR-acquired images were used to calculate fat fraction and iron content in a single breath-hold in 109 adult patients. Proton density fat fraction (PDFF) was prospectively estimated using complex-based data reconstruction with multipeak fat modeling...
January 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28110361/the-impact-of-routine-whole-spine-mri-screening-in-the-evaluation-of-spinal-degenerative-diseases
#3
Rishi Mugesh Kanna, Younis Kamal, Anupama Mahesh, Prakash Venugopal, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: Magnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can be asymptomatic but significant. The efficacy of whole spine T2 sagittal screening in providing additional information has been demonstrated in several spinal diseases but its routine use in patients with spinal degenerative diseases has not been studied...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28110328/impact-of-medical-tv-shows-on-preprocedural-fear-of-surgical-in-house-patients
#4
Kai Witzel, Horst J Koch, Cornelia Kaminski
: Background and Hypotheses: The growing number of medical television series and the increasing amount of time people spend watching TV will have an influence on what they expect from their treatment in a hospital. We suspect that reality as presented in the media and the actual reality of hospitals are not always conceived of as two different worlds. Many medical TV shows present dramatic, life-threatening operations much more often than they occur in reality. Patients who frequently watch such shows might be induced to believe that even routine operations are often dangerous, which could result in higher levels of fear before such an operation...
January 21, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28110298/idh1-mutation-in-diffuse-gliomas-in-persons-age-55-years-and-over
#5
Chase Robinson, B K Kleinschmidt-DeMasters
Diffuse astrocytoma (DA), anaplastic astrocytoma (AA), and glioblastoma (GBM) are defined by the World Health Organization (WHO) based on IDH-mutational status. The vast majority of IDH-mutated gliomas (90% of which involve a mutation in IDH1 R132H, which can be assessed by IDH1 immunohistochemistry [IHC]) occur in persons younger than 55 years of age. This raises the question as to the prevalence of IDH-mutant tumors in older persons and whether the gliomas in older patients should be routinely tested. Since January 1, 2014, we have employed a standard screening panel for all gliomas regardless of patient age...
January 21, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28110285/validation-of-a-clinical-screening-instrument-for-tumour-predisposition-syndromes-in-patients-with-childhood-cancer-tups-protocol-for-a-prospective-observational-multicentre-study
#6
Floor A M Postema, Saskia M J Hopman, Corianne A J M de Borgie, Peter Hammond, Raoul C Hennekam, Johannes H M Merks, Cora M Aalfs, Jakob K Anninga, Lieke Pv Berger, Fonnet E Bleeker, Eveline Sjm de Bont, Corianne Ajm de Borgie, Charlotte J Dommering, Natasha Ka van Eijkelenburg, Peter Hammond, Raoul C Hennekam, Marry M van den Heuvel-Eibrink, Saskia Mj Hopman, Marjolijn Cj Jongmans, Wijnanda A Kors, Tom Gw Letteboer, Jan Lcm Loeffen, Johannes Hm Merks, Maran Jw Olderode-Berends, Floor Am Postema, Anja Wagner
INTRODUCTION: Recognising a tumour predisposition syndrome (TPS) in patients with childhood cancer is of significant clinical relevance, as it affects treatment, prognosis and facilitates genetic counselling. Previous studies revealed that only half of the known TPSs are recognised during standard paediatric cancer care. In current medical practice it is impossible to refer every patient with childhood cancer to a clinical geneticist, due to limited capacity for routine genetic consultation...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110281/incidence-risk-factors-and-risk-prediction-of-hospital-acquired-suspected-adverse-drug-reactions-a-prospective-cohort-of-ugandan-inpatients
#7
Ronald Kiguba, Charles Karamagi, Sheila M Bird
OBJECTIVES: To determine the incidence and risk factors of hospital-acquired suspected adverse drug reactions (ADRs) among Ugandan inpatients. We also constructed risk scores to predict and qualitatively assess for peculiarities between low-risk and high-risk ADR patients. METHODS: Prospective cohort of consented adults admitted on medical and gynaecological wards of the 1790-bed Mulago National Referral Hospital. Hospital-acquired suspected ADRs were dichotomised as possible (possible/probable/definite) or not and probable (probable/definite) or not, using the Naranjo scale...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110270/assessment-of-neonatal-pain-during-heel-prick-lancet-vs-needle-a-randomized-controlled-study
#8
Carl Britto, Suman P N Rao
BACKGROUND: Heel prick is a frequent painful procedure in newborns. A lancet or a 26-gauge needle is used for a heel prick in India. OBJECTIVE: To compare the pain caused by heel prick with a lancet or a 26-gauge needle in newborns admitted in the neonatal intensive care unit (NICU) using the preterm infant pain profile (PIPP). METHODS: This randomized controlled trial was conducted over 2 months in a Level III NICU with a sample size of 40 subjects (20 in each group), which was required for the study to have a power of 80% with an alpha error of 0...
January 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28110196/application-of-modern-anticoincidence-ac-system-in-hpge-%C3%AE-spectrometry-for-the-detection-limit-lowering-of-the-radionuclides-in-air-filters
#9
Magdalena Długosz-Lisiecka
The use of active and passive shields can substantially reduce the Minimum Detectable Activity (MDA) of the γ-ray counting systems, rejecting events induced by cosmic-rays or by environmental radioactivity. However, the size and geometry of the samples lead to limitations in the background reduction in routine measurements. The Minimum Detectable Activity (MDA) values for low energy of γ-ray emitting radionuclides (<200 keV) deposited in three typical air filter geometries have been compared for anticoincidence and single HPGe detector mode of γ-spectrometry systems...
January 19, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28109936/precision-phenotyping-in-heart-failure-and-pattern-clustering-of-ultrasound-data-for-the-assessment-of-diastolic-dysfunction
#10
Alaa Mabrouk Salem Omar, Sukrit Narula, Mohamed Ahmed Abdel Rahman, Gianni Pedrizzetti, Hala Raslan, Osama Rifaie, Jagat Narula, Partho P Sengupta
OBJECTIVES: The aim of this study was to investigate whether cluster analysis of left atrial and left ventricular (LV) mechanical deformation parameters provide sufficient information for Doppler-independent assessment of LV diastolic function. BACKGROUND: Medical imaging produces substantial phenotyping data, and superior computational analyses could allow automated classification of repetitive patterns into patient groups with similar behavior. METHODS: The authors performed a cluster analysis and developed a model of LV diastolic function from an initial exploratory cohort of 130 patients that was subsequently tested in a prospective cohort of 44 patients undergoing cardiac catheterization...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109918/%C3%AE-ct-based-trabecular-anisotropy-can-be-reproducibly-computed-from-hr-pqct-scans-using-the-triangulated-bone-surface
#11
Hadi S Hosseini, Ghislain Maquer, Philippe K Zysset
The trabecular structure can be assessed at the wrist or tibia via high-resolution peripheral quantitative computed tomography (HR-pQCT). Yet on this modality, the performance of the existing methods, evaluating trabecular anisotropy is usually overlooked, especially in terms of reproducibility. We thus proposed to compare the TRI routine used by SCANCO Medical AG (Brüttisellen, Switzerland), the classical mean intercept length (MIL), and the grey-level structure tensor (GST) to the mean surface length (MSL), a new method for evaluating a second-order fabric tensor based on the triangulation of the bone surface...
January 18, 2017: Bone
https://www.readbyqxmd.com/read/28109890/sunlight-damage-to-cellular-dna-focus-on-oxidatively-generated-lesions
#12
André Passaglia Schuch, Natália Cestari Moreno, Natielen Jacques Schuch, Carlos Frederico Martins Menck, Camila Carrião Machado Garcia
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the most significant environmental DNA-damaging agents to which humans are exposed. Sunlight, specifically UVB and UVA, triggers various types of DNA damage. Although sunlight, mainly UVB, is necessary for the production of vitamin D, which is necessary for human health, DNA damage may have several deleterious consequences, such as cell death, mutagenesis, photoaging and cancer. UVA and UVB photons can be directly absorbed not only by DNA, which results in lesions, but also by the chromophores that are present in skin cells...
January 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28109858/radiological-dilemma-in-an-extra-axial-petroclival-lesion-low-vs-high-grade
#13
Madhivanan Karthigeyan, Chirag Kamal Ahuja, Debjyoti Chatterjee, Pravin Salunke
BACKGROUND: Radiological differentiation between a low and high grade lesion is crucial on deciding the extent of resection and prognostication. Occasionally the imaging features can be confusing between the two. We report such a case which was a radiological dilemma. The lesion appeared apparently benign and extra-axial on routine magnetic resonance (MR) sequences. However, there were subtle clinical and imaging clues towards high grade lesion. CASE DESCRIPTION: A 27-year-old lady presented with multiple cranial nerve palsies, gait ataxia and features of raised intracranial pressure...
January 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28109735/implementation-and-evaluation-of-two-educational-strategies-to-improve-screening-for-eating-disorders-in-pediatric-primary-care
#14
Holly C Gooding, Elizabeth Cheever, Sara F Forman, Jonathan Hatoun, Farah Jooma, Currie Touloumtzis, Louis Vernacchio
PURPOSE: Routine screening for disordered eating or body image concerns is recommended by the American Academy of Pediatrics. We evaluated the ability of two educational interventions to increase screening for eating disorders in pediatric primary care practice, predicting that the "active-learning" group would have an increase in documented screening after intervention. METHODS: We studied 303 practitioners in a large independent practice association located in the northeastern United States...
January 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28109733/course-of-participation-after-subarachnoid-hemorrhage
#15
Elize M Kruisheer, Irene M C Huenges Wajer, Johanna M A Visser-Meily, Marcel W M Post
OBJECTIVES: The study aimed to investigate participation problems in patients with subarachnoid hemorrhage (SAH), and the course of participation between 3 and 12 months post-SAH, and to identify determinants of this course. DESIGN: This is a prospective cohort study. SETTING: The study was done in the SAH outpatient clinic at the University Medical Center Utrecht. SUBJECTS: Subjects included patients independent in activities of daily living who visited the SAH outpatient clinic for a routine follow-up visit 3 months after the event...
January 18, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28109728/the-utility-of-hair-cortisol-concentrations-in-the-prediction-of-ptsd-symptoms-following-traumatic-physical-injury
#16
Maria L Pacella, Bryce Hruska, Susann Steudte-Schmiedgen, Richard L George, Douglas L Delahanty
RATIONALE: Although cortisol alterations have been associated with posttraumatic stress disorder (PTSD) and PTSD symptoms (PTSS), the direction of association is mixed. Cortisol which is measured in blood, saliva, or urine is subject to transient factors that may confound results. Recent advances in cortisol sampling techniques provide novel opportunities to address these inconsistencies. Hair cortisol sampling is a non-invasive method for the retrospective assessment of long-term integrated cortisol, yet its utility at predicting PTSS has not been assessed in acute injury victims...
January 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28109672/optimizing-follow-up-after-anatomic-total-shoulder-arthroplasty
#17
Bradley Schoch, Jean David Werthel, Cathy D Schleck, William S Harmsen, John Sperling, Joaquín Sánchez-Sotelo, Robert H Cofield
BACKGROUND: With increases in both total shoulder arthroplasty (TSA) volumes and patient life expectancies, the number of patients requiring follow-up after shoulder arthroplasty continues to grow exponentially. The purpose of this study is to establish a data-based follow-up schedule minimizing unnecessary patient and health care system costs without sacrificing patient care. METHODS: Between January 1975 and January 2013, 2786 consecutive anatomic TSAs were performed at our institution...
January 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28109650/development-and-evaluation-of-a-generic-education-program-for-chronic-diseases-in-childhood
#18
Gundula Ernst, Ingo Menrath, Karin Lange, Nora Eisemann, Doris Staab, Ute Thyen, Ruediger Szczepanski
OBJECTIVE: To support families with a chronically ill child, a modular curriculum and new healthcare structures (trainer education, quality management) for a group self-management program (ModuS) were developed. ModuS focuses on common psychosocial aspects of chronic conditions and comprises generic and disease-specific modules. A pilot test was conducted for asthma by comparing ModuS with an established asthma-specific education program (CAE). METHODS: Under routine care conditions, 491 children (6-17 years) with asthma and their parents participated in a multi-center prospective study (265 ModuS; 226 CAE)...
January 12, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28109642/non-routine-discharge-from-military-service-mental-illness-substance-use-disorders-and-suicidality
#19
Emily Brignone, Jamison D Fargo, Rebecca K Blais, Marjorie E Carter, Matthew H Samore, Adi V Gundlapalli
INTRODUCTION: Mental illness and substance use disorders among newly returned military service members pose challenges to successful reintegration into civilian life and, in extreme cases, may lead to outcomes such as incarceration, homelessness, and suicide. One potential early indicator for these difficulties is non-routine discharge from military service. METHODS: Using data from the Veterans Health Administration (VHA) for 443,360 active duty service Veterans who deployed to Afghanistan and Iraq and subsequently utilized VHA services between Fiscal Years 2004 and 2013, this study examined risk for receiving a VHA-documented diagnosis of mental illness, substance use disorders, and suicidality as a function of discharge type, controlling for demographic and military service covariates...
January 18, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28109584/net-effects-of-nitrogen-fertilization-on-the-nutritive-value-and-digestibility-of-oat-forages
#20
W K Coblentz, M S Akins, J S Cavadini, W E Jokela
Applications of soil amendments containing N are part of routine forage-management strategies for grasses, with a primary goal of increasing forage yield. However, the effects of N fertilization on forage nutritive value, estimates of energy density, and in vitro dry matter or neutral detergent fiber disappearance sometimes have been erratic or inconsistent. Our objectives were to evaluate the effects of N fertilization on the nutritive value of a single cultivar (ForagePlus, Kratz Farms, Slinger, WI) of fall-grown oat fertilized at planting with 20, 40, 60, 80, or 100 kg of N/ha of urea or 2 rates of dairy slurry (42,300 or 84,600 L/ha)...
January 18, 2017: Journal of Dairy Science
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