Meifeng Nie, Shuyu Wu, Yiyi Chen, Yangtao Wu, Ruitong Chen, Yue Liu, Mingxi Yue, Yao Jiang, Dekui Qiu, Man Yang, Zikang Wang, Jiahua Gao, Hualong Xiong, Ruoyao Qi, Jinhang He, Jinlei Zhang, Liang Zhang, Yingbin Wang, Mujin Fang, Yuqiong Que, Youliang Yao, Shaowei Li, Jun Zhang, Qinjian Zhao, Quan Yuan, Tianying Zhang, Ningshao Xia
Micro/Nano-scale particles are widely used as vaccine adjuvants to enhance immune response and improve antigen stability. While aluminum salt is one of the most common adjuvants approved for human use, its immunostimulatory capacity is suboptimal. In this study, we modified risedronate, an immunostimulant and anti-osteoporotic drug, to create zinc salt particle-based risedronate (Zn-RS), also termed particulate risedronate. Compared to soluble risedronate, micronanoparticled Zn-RS adjuvant demonstrated increased recruitment of innate cells, enhanced antigen uptake locally, and a similar antigen depot effect as aluminum salt...
November 14, 2023: Journal of Controlled Release