keyword
https://read.qxmd.com/read/38505524/inhibition-of-rankl-improves-the-skeletal-phenotype-of-adenine-induced-chronic-kidney-disease-in-mice
#1
JOURNAL ARTICLE
Corinne E Metzger, Mizuho Kittaka, Alec N LaPlant, Yasuyoshi Ueki, Matthew R Allen
Skeletal fragility and high fracture rates are common in CKD. A key component of bone loss in CKD with secondary hyperparathyroidism is high bone turnover and cortical bone deterioration through both cortical porosity and cortical thinning. We hypothesized that RANKL drives high bone resorption within cortical bone leading to the development of cortical porosity in CKD (study 1) and that systemic inhibition of RANKL would mitigate the skeletal phenotype of CKD (study 2). In study 1, we assessed the skeletal properties of male and female Dmp1-cre RANKLfl/fl (cKO) and control genotype ( Ranklfl/fl ; Con) mice after 10 wk of adenine-induced CKD (AD; 0...
February 2024: JBMR Plus
https://read.qxmd.com/read/38368307/twelve-month-resistance-and-impact-exercise-program-or-risedronate-provides-a-relative-benefit-to-hip-bone-structure-in-postmenopausal-women-results-from-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
R Blay, L E Flores, K Kupzyk, N Waltman, J Lappe, L Mack, L Bilek
UNLABELLED: Bone strength estimates are important for fracture prevention. This study compared bone strength changes in postmenopausal women with low bone mass who were assigned to 12 months of exercise, a bone medication, or control. Exercise and bone medications benefited structure at the hip. Structure should be considered in fracture prevention research. PURPOSE: Exercise and bisphosphonates reduce fracture risk, but their impact on estimates of bone strength remains uncertain...
February 17, 2024: Osteoporosis International
https://read.qxmd.com/read/38367035/role-of-zinc-in-health-and-disease
#3
REVIEW
Lucy I Stiles, Kevin Ferrao, Kosha J Mehta
This review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. Zinc cannot be stored in significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport dietary zinc ions from the duodenum into the enterocyte, ZnT1 transports zinc ions from the enterocyte into the circulation, and ZnT5B (bidirectional zinc transporter) facilitates endogenous zinc secretion into the intestinal lumen...
February 17, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38342711/anti-osteoporotic-drug-efficacy-for-periprosthetic-bone-loss-after-total-hip-arthroplasty-a-systematic-review-and-network-meta-analysis
#4
JOURNAL ARTICLE
Masaki Hatano, Yasuhiko Koizumi, Norio Yamamoto, Kota Miyoshi, Kensuke Kawabata, Takeyuki Tanaka, Sakae Tanaka, Akihiro Shiroshita, Yuki Kataoka
BACKGROUND: Periprosthetic bone loss following total hip arthroplasty (THA) threatens prosthesis stability. This systematic review and network meta-analysis aimed to compare the efficacy of anti-osteoporotic drugs for measures of hip function according to functional outcomes, periprosthetic femoral bone mineral density loss in each Gruen zone, and revision surgery after THA. METHODS: The systematic search of six literature databases was conducted in December 2021 in accordance with PRISMA guidelines...
February 10, 2024: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://read.qxmd.com/read/38313307/denosumab-teriparatide-and-bisphosphonates-for-glucocorticoid-induced-osteoporosis-a-bayesian-network-meta-analysis
#5
Liang Dong, Lianghai Jiang, Zhengwei Xu, Xiaobo Zhang
Background: Several medications have been used for glucocorticoids-induced osteoporosis (GIO). However, the best therapeutic option for GIO is still controversial. A Bayesian network meta-analysis was conducted to compare the efficacy and safety of denosumab, teriparatide and bisphosphonates for patients with GIO. Methods: Relevant randomized controlled trials published in PubMed, Embase, Cochrane Library and ClinicalTrials.gov up to August 2023 were searched. The following efficiency and safety outcomes were extracted for comparison: bone mineral density (BMD) percentage changes in lumbar spine, femur neck and total hip, and incidences of adverse events (AEs), serious adverse events (SAEs), vertebrae and non-vertebrae fracture...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38244843/risedronate-functionalized-manganese-hydroxyapatite-amorphous-particles-a-potent-adjuvant-for-subunit-vaccines-and-cancer-immunotherapy
#6
JOURNAL ARTICLE
Xiuli Zhang, Mingjing Wei, Zhigang Zhang, Yarong Zeng, Feihong Zou, Sibo Zhang, Zhiping Wang, Fentian Chen, Hualong Xiong, Yufang Li, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Jun Zhang, Ying Gu, Qinjian Zhao, Shaowei Li, Ningshao Xia
The cGAS-STING pathway and the Mevalonate Pathway are druggable targets for vaccine adjuvant discovery. Manganese (Mn) and bisphosphonates are known to exert adjuvant effects by targeting these two pathways, respectively. This study found the synergistic potential of the two pathways in enhancing immune response. Risedronate (Ris) significantly amplified the Mn adjuvant early antibody response by 166-fold and fortified its cellular immunity. However, direct combination of Mn2+ and Ris resulted in increased adjuvant toxicity (40% mouse mortality)...
January 18, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38198389/influence-of-risedronate-on-orthodontic-tooth-movement-in-rodents-a-systematic-review-and-case-report
#7
JOURNAL ARTICLE
Roberta Magalhães Miranda, Juliana Lourdes Fernandes, Mariana de Souza Santos, Humberto Jácome-Santos, Roselaine Moreira Coelho Milagres, Henrique Pretti, Lucas Guimarães Abreu, Soraia Macari
INTRODUCTION: Bisphosphonates have an inhibitory impact on osteoclastic activity, reducing bone resorption. However, the influence of risedronate on tooth movement is not well-defined. OBJECTIVE: This systematic review assessed the effect of risedronate intake on orthodontic tooth movement. A case report was also provided. METHODS: Two independent reviewers searched six databases (PubMed, Web of Science, Ovid, Lilacs, Scopus, and Open Grey)...
2024: Dental Press Journal of Orthodontics
https://read.qxmd.com/read/38197974/safety-and-effectiveness-of-risedronate-in-paget-s-disease-of-bone-postmarketing-surveillance-study-in-japan
#8
JOURNAL ARTICLE
Jun Hashimoto, Yuki Arai, Shinsuke Kurosu, Toshimi Ikezaki
INTRODUCTION: We conducted an all-case postmarketing surveillance study between 2008 and 2017 to evaluate the safety and effectiveness of risedronate for Paget's disease of bone (PDB) in Japan. MATERIAL AND METHODS: This study registered all patients who received once-daily risedronate 17.5 mg for the treatment of PDB and collected data over a 48-week follow-up period per treatment cycle for each patient. RESULTS: The safety analysis set included 184 patients (mean age, 63...
January 2024: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/38145750/unravelling-the-potential-of-triflusal-as-an-anti-tb-repurposed-drug-by-targeting-replication-protein-dcia
#9
JOURNAL ARTICLE
Waseem Ali, Salma Jamal, Rishabh Gangwar, Faraz Ahmed, Isha Pahuja, Rahul Sharma, Ved Prakash Dwivedi, Meetu Agarwal, Sonam Grover
The increasing prevalence of drug-resistant Tuberculosis (TB) is imposing extreme difficulties in controlling the TB infection rate globally, making treatment critically challenging. To combat the prevailing situation, it is crucial to explore new anti-TB drugs with a novel mechanism of action and high efficacy. The Mycobacterium tuberculosis (M.tb)DciA is an essential protein involved in bacterial replication and regulates its growth. DciA interacts with DNA and provides critical help in binding other replication machinery proteins to the DNA...
December 23, 2023: Microbes and Infection
https://read.qxmd.com/read/38138351/bbd-driven-fabrication-of-hydroxyapatite-engineered-risedronate-loaded-thiolated-chitosan-nanoparticles-and-their-in-silico-in-vitro-and-ex-vivo-studies
#10
JOURNAL ARTICLE
Zoya Saifi, Tanya Ralli, Md Rizwanullah, Meraj Alam, Divya Vohora, Showkat R Mir, Saima Amin, Sadia Ameen
Risedronate sodium (RIS) exhibits limited bioavailability and undesirable gastrointestinal effects when administered orally, necessitating the development of an alternative formulation. In this study, mPEG-coated nanoparticles loaded with RIS-HA-TCS were created for osteoporosis treatment. Thiolated chitosan (TCS) was synthesized using chitosan and characterized using DSC and FTIR, with thiol immobilization assessed using Ellman's reagent. RIS-HA nanoparticles were fabricated and conjugated with synthesized TCS...
November 30, 2023: Micromachines
https://read.qxmd.com/read/38112890/the-effectiveness-of-ibandronate-in-reducing-the-risk-of-nonvertebral-fractures-in-women-with-osteoporosis-systematic-review-and-meta-analysis-of-observational-studies
#11
REVIEW
Carlos Alves, Diogo Mendes, Ana Penedones, Tânia Oliveira, António Donato, Francisco Batel-Marques
BACKGROUND: Ibandronate is effective in reducing the risk of vertebral fractures, but experimental evidence offers conflicting results regarding nonvertebral fractures. Real-world evidence has been published evaluating the anti-nonvertebral fracture effect of ibandronate. AIM: This meta-analysis of observational studies assessed the effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis. METHOD: Pubmed/Embase databases were searched for observational studies...
December 19, 2023: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/38013362/risk-factors-for-new-vertebral-compression-fracture-after-vertebroplasty-and-efficacy-of-osteoporosis-treatment-a-strobe-compliant-retrospective-study
#12
JOURNAL ARTICLE
Seongjoo Park, Sang Sik Choi, Heezoo Kim, Sang Yoon Byun, Chung Hun Lee
Vertebroplasty (VP) effectively treats vertebral compression fractures (VCFs). However, the issue of secondary new VCFs (SNVCFs) after VP is yet to be addressed. Therefore, identification of risk factors for SNVCFs after VP may aid the development of strategies to minimize SNVCF risk. This study aimed to retrospectively evaluate risk factors for SNVCFs after VP, including those associated with the type of anti-osteoporotic treatment administered after VP. Data from 128 patients who underwent single-level VP were collected and reviewed...
November 24, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38003342/synergic-action-of-systemic-risedronate-and-local-rutherpy-in-peri-implantar-repair-of-ovariectomized-rats-biomechanical-and-molecular-analysis
#13
JOURNAL ARTICLE
Bruna Kaori Namba Inoue, Laura Vidoto Paludetto, Naara Gabriela Monteiro, Fábio Roberto de Souza Batista, Igor Lebedenco Kitagawa, Roberto Santana da Silva, Cristina Antoniali, Paulo Noronha Lisboa Filho, Roberta Okamoto
Postmenopausal osteoporosis and poor dietary habits can lead to overweightness and obesity. Bisphosphonates are the first-line treatment for osteoporosis. However, some studies show that they may increase the risk of osteonecrosis of the jaw. Considering the antimicrobial, angiogenic and vasodilatory potential of nitric oxide, this study aims to evaluate the local activity of this substance during the placement of surface-treated implants. Seventy-two Wistar rats were divided into three groups: SHAM (SHAM surgery), OVX + HD (ovariectomy + cafeteria diet), and OVX + HD + RIS (ovariectomy + cafeteria diet + sodium risedronate treatment), which were further subdivided according to the surface treatment of the future implant: CONV (conventional), TE10, or TE100 (TERPY at 10 or 100 μM concentration); n = 8 per subgroup...
November 10, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37972764/micronanoparticled-risedronate-exhibits-potent-vaccine-adjuvant-effects
#14
JOURNAL ARTICLE
Meifeng Nie, Shuyu Wu, Yiyi Chen, Yangtao Wu, Ruitong Chen, Yue Liu, Mingxi Yue, Yao Jiang, Dekui Qiu, Man Yang, Zikang Wang, Jiahua Gao, Hualong Xiong, Ruoyao Qi, Jinhang He, Jinlei Zhang, Liang Zhang, Yingbin Wang, Mujin Fang, Yuqiong Que, Youliang Yao, Shaowei Li, Jun Zhang, Qinjian Zhao, Quan Yuan, Tianying Zhang, Ningshao Xia
Micro/Nano-scale particles are widely used as vaccine adjuvants to enhance immune response and improve antigen stability. While aluminum salt is one of the most common adjuvants approved for human use, its immunostimulatory capacity is suboptimal. In this study, we modified risedronate, an immunostimulant and anti-osteoporotic drug, to create zinc salt particle-based risedronate (Zn-RS), also termed particulate risedronate. Compared to soluble risedronate, micronanoparticled Zn-RS adjuvant demonstrated increased recruitment of innate cells, enhanced antigen uptake locally, and a similar antigen depot effect as aluminum salt...
November 14, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37969460/efficacy-and-safety-of-different-anti-osteoporotic-drugs-for-the-spinal-fusion-surgery-a-network-meta-analysis
#15
JOURNAL ARTICLE
Xiao-Yuan He, Huan-Xiong Chen, Zhi-Rong Zhao
BACKGROUND: Administering anti-osteoporotic agents to patients perioperatively is a widely accepted approach for improving bone fusion rates and reducing the risk of complications. The best anti-osteoporotic agents for spinal fusion surgery remain unclear. AIM: To investigate the efficacy and safety of different anti-osteoporotic agents in spinal fusion surgery via network meta-analysis. METHODS: Searches were conducted in four electronic databases (PubMed, EMBASE, Web of Science, the Cochrane Library and China National Knowledge Infrastructure (CNKI) from inception to November 2022...
October 26, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/37908566/multiple-spontaneous-vertebral-fractures-in-a-younger-post-menopausal-woman-upon-stopping-denosumab-therapy
#16
Xun Yang Hu, William D Leslie, Gregory Kline
Denosumab is a widely used medication for the treatment of osteoporosis. It has been observed in recent years that abruptly stopping denosumab leads to an increase in bone turnover markers, a decrease in bone mineral density, and a higher incidence of vertebral fractures. We present the case of a 53-year-old woman with few comorbidities and no prior fragility fractures who experienced 4 spontaneous and severely debilitating vertebral fractures 5-months post denosumab discontinuation. At the time of her fractures, she was found to have markedly elevated bone turnover markers, despite bone mineral density that was not significantly changed from measurements done while on denosumab treatment...
May 2023: JCEM Case Rep
https://read.qxmd.com/read/37908466/two-cases-of-external-auditory-canal-osteonecrosis-in-patients-on-antiresorptive-therapy-for-osteoporosis
#17
Shejil Kumar, Terrence Diamond, Joanna Walton
Bisphosphonates and denosumab have demonstrated overwhelmingly favorable skeletal benefit/risk profile in managing postmenopausal osteoporosis. External auditory canal osteonecrosis is a rare skeletal complication of antiresorptives previously described in 11 patients with bisphosphonate exposure and 1 bisphosphonate-naïve patient on denosumab. We present 2 patients who developed external auditory canal osteonecrosis while taking antiresorptives for postmenopausal osteoporosis; a 79-year-old asymptomatic bisphosphonate-naïve woman with 2-year exposure to denosumab, and a 64-year-old woman with otalgia after 5 years of risedronate and 5 years of denosumab treatment...
March 2023: JCEM Case Rep
https://read.qxmd.com/read/37904317/what-is-the-role-of-risedronate-in-the-primary-and-secondary-prevention-of-fractures-associated-with-osteoporosis-in-postmenopausal-women-a-cochrane-review-summary-with-commentary
#18
JOURNAL ARTICLE
Sina Arman
No abstract text is available yet for this article.
October 30, 2023: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/37770860/clinicians-%C3%A2-views-of-prescribing-oral-and-intravenous-bisphosphonates-for-osteoporosis-a-qualitative-study
#19
JOURNAL ARTICLE
Simon Bishop, Melanie Jay Narayanasamy, Zoe Paskins, Nadia Corp, Anastasios Bastounis, Jill Griffin, Neil Gittoes, Jo Leonardi-Bee, Tessa Langley, Opinder Sahota
BACKGROUND: Bisphosphonate medications, including alendronate, ibandronate and risedronate administered orally and zoledronate, administered intravenously, are commonly prescribed for the treatment of osteoporosis based on evidence that, correctly taken, bisphosphonates can improve bone strength and lead to a reduction in the risk of fragility fractures. However, it is currently unclear how decisions to select between bisphosphonate regimens, including intravenous regimen, are made in practice and how clinicians support patients with different treatments...
September 29, 2023: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/37765307/enhancing-osteoporosis-treatment-through-targeted-nanoparticle-delivery-of-risedronate-in-vivo-evaluation-and-bioavailability-enhancement
#20
JOURNAL ARTICLE
Zoya Saifi, Sadat Shafi, Tanya Ralli, Shreshta Jain, Divya Vohora, Showkat Rasool Mir, Abdulsalam Alhalmi, Omar M Noman, Ahmad Alahdab, Saima Amin
Risedronate-loaded mPEG-coated hydroxyapatite, thiolated chitosan-based (coated) and non-coated nanoparticles were tested for their potential effects in the treatment of osteoporosis. The prepared nanoparticles were evaluated for their bone-targeting potential by inducing osteoporosis in female Wistar rats via oral administration of Dexona (dexamethasone sodium phosphate). In vivo pharmacokinetic and pharmacodynamic studies were performed on osteoporotic rat models treated with different formulations. The osteoporotic model treated with the prepared nanoparticles indicated a significant effect on bone...
September 18, 2023: Pharmaceutics
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