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Alendronate

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https://www.readbyqxmd.com/read/27925290/bisphosphonate-withdrawal-effects-on-bone-formation-and-bone-resorption-in-maturing-male-mice
#1
Frank C Ko, Lamya Karim, Daniel J Brooks, Mary L Bouxsein, Marie B Demay
Bisphosphonates are being increasingly used to treat pediatric patients with skeletal disorders. However, the effects of long-term bisphosphonate therapy and cessation of therapy during growth are unclear. Thus, studies were undertaken to determine the effects of alendronate discontinuation following treatment of C57Bl/6 mice during the period of rapid skeletal growth. Compared to vehicle-treated mice, 16 weeks of alendronate treatment starting at 18 days of age resulted in a 3.7 fold increase in trabecular bone in the setting of suppressed bone formation...
December 7, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27921147/can-the-alendronate-dosage-be-altered-when-combined-with-high-frequency-loading-in-osteoporosis-treatment
#2
C B Correa, G V Camargos, M Chatterjee, M F Mesquita, A A Del Bel Cury, I Naert, J Duyck, K Vandamme
: Alendronate therapy has been associated with serious side effects. Altering the alendronate concentration and combining with high-frequency loading as mechanical intervention was explored in this animal study as a treatment for osteoporosis. The bone anabolic potency of high-frequency loading was overruled by the different alendronate dosages applied in the present study. Further exploration of reduced hormonal therapy associated with mechanical interventions in osteoporosis treatment should be sought...
December 5, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27915335/network-meta-analysis-of-pharmacological-agents-for-osteoporosis-treatment-and-fracture-prevention
#3
Xu-Cheng Yang, Zhen-Han Deng, Ting Wen, Wei Luo, Wen-Feng Xiao, Rui-Bo Zhao, Yu-Sheng Li
BACKGROUND AND OBJECTIVE: Osteoporosis afflicts a large number of populations in the world and is featured by systemic impairment of bone mass and strength which may further trigger an increase in the risk of fragile fractures. This network meta-analysis (NMA) is designed to distinguish therapies more preferable than others with respect to efficacy and safety. METHODS: We searched the medical literature for relevant studies systematically. Both direct and indirect evidence were synthesized to compare the efficacy, described by odds ratios (OR) and 95% credible intervals (CrI)...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27904727/influence-of-early-bisphosphonate-administration-for-fracture-healing-in-patients-with-osteoporotic-proximal-humerus-fractures
#4
Joong-Bae Seo, Jae-Sung Yoo, Jee-Won Ryu, Kun-Woong Yu
BACKGROUND: Bisphosphonates are generally known to adversely affect fracture healing because they inhibit osteoclastic bone resorption. However, some authors argue that bisphosphonates have no adverse effect on the restoration of the mechanical integrity of long bones after fractures. It is unclear whether bisphosphonates can be initiated safely in patients with acute proximal humerus fractures. The aim of this study was to determine whether the early use of a bisphosphonate affects healing and outcomes of osteoporotic proximal humerus fractures treated with a locking compression plate...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27887884/calcium-phosphate-nanoparticles-functionalized-with-alendronate-conjugated-polyethylene-glycol-peg-for-the-treatment-of-bone-metastasis
#5
Weijing Chu, Yanjuan Huang, Chanzhen Yang, Yunhui Liao, Xuefei Zhang, Mina Yan, Shengmiao Cui, Chunshun Zhao
Because of the peculiarity of the bone microstructure, the uptake of chemotherapeutics often happens at non-targeted sites, which induces side effects. In order to solve this problem, we designed a bone-targeting drug delivery system that can release drug exclusively in the nidus of the bone. Alendronate (ALN), which has a high ability to target to hydroxyapatite, was used to fabricate double ALN-conjugated poly (ethylene glycol) 2000 material (ALN-PEG2k-ALN). The ALN-PEG2k-ALN was characterized using (1)H NMR and (31)P NMR and FTIR...
November 22, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27876532/efficacy-of-the-c-terminal-telopeptide-test-in-predicting-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaw-a-systematic-review
#6
REVIEW
K J Dal Prá, C A A Lemos, R Okamoto, A M P Soubhia, E P Pellizzer
This systematic review evaluated the efficacy of the morning fasting serum C-terminal telopeptide (CTX) test in predicting the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). A comprehensive search of studies published up to March 2016, and listed in the PubMed/MEDLINE, Web of Science, and Cochrane Library databases, was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This review has been registered in the PROSPERO international prospective register of systematic reviews (CRD42016036717)...
November 19, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27869358/disease-systems-analysis-of-bone-mineral-density-and-bone-turnover-markers-in-response-to-alendronate-placebo-and-washout-in-postmenopausal-women
#7
J Berkhout, J A Stone, K M Verhamme, M Danhof, T M Post
A previously established mechanism-based disease systems model for osteoporosis that is based on a mathematically reduced version of a model describing the interactions between osteoclast (bone removing) and osteoblast (bone forming) cells in bone remodeling has been applied to clinical data from women (n = 1,379) receiving different doses and treatment regimens of alendronate, placebo, and washout. The changes in the biomarkers, plasma bone-specific alkaline phosphatase activity (BSAP), urinary N-telopeptide (NTX), lumbar spine bone mineral density (BMD), and total hip BMD, were linked to the underlying mechanistic core of the model...
November 21, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27866217/osteonecrosis-of-the-jaw-onj-and-atypical-femoral-fracture-aff-in-an-osteoporotic-patient-chronically-treated-with-bisphosphonates
#8
A Sánchez, R Blanco
The aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87 years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999-2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006-2008). She received occasional supplements of ergocalciferol...
November 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27847678/a-systematic-review-of-treatment-strategies-for-degenerative-lumbar-spine-fusion-surgery-in-patients-with-osteoporosis
#9
Charla R Fischer, Gregory Hanson, Melinda Eller, Ronald A Lehman
PURPOSE: To evaluate the current evidence in the literature on treatment strategies for degenerative lumbar spine fusion in patients with osteoporosis. METHODS: A systematic review of the literature from 1950 to 2015. RESULTS: The review of the literature yielded 15 studies on the effect of treatment options for osteoporosis on lumbar fusion rates. This study evaluated only degenerative lumbar spine conditions and excluded deformity patients...
December 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27824143/engineered-nanomedicine-with-alendronic-acid-corona-improves-targeting-to-osteosarcoma
#10
Tuyen Duong Thanh Nguyen, Arunkumar Pitchaimani, Santosh Aryal
We engineered nanomedicine with the stealth corona made up of densely packed bone seeking ligand, alendronic acid. In a typical nanoconstruct, alendronic acid is conjugated with hydrophilic head moiety of phospholipid that has an ability to self-assemble with hydrophobic polymeric core through its hydrophobic long carbon-chain. Proposed nanomedicine has three distinct compartments namely; poly(l-lactic-co-glycolic acid) polymeric core acting as a drug reservoir and skeleton of the nanoconstruct, phospholipid monolayer covers the core acting as a diffusion barrier, and a densely packed alendronic acid corona acting as a stabilizer and targeting moiety...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27813398/treatment-of-osteoporosis-secondary-to-hypogonadism-in-prostate-carcinoma-patients-a-prospective-randomized-multicenter-international-study-with-denosumab-vs-alendronate
#11
Carlo Doria, Giulia R Mosele, Federico Solla, Gianluca Maestretti, Massimo Balsano, Roberto M Scarpa
BACKGROUND: Osteoporosis is a complication of androgen deprivation therapy (ADT) in men with prostate carcinoma. This is a multicenter, randomized, double-blind prospective study on use of Denosumab versus Alendronate in the therapy of secondary osteoporosis related to ADT. METHODS: 234 patients with diagnosis of osteoporosis underwent ADT for prostate cancer were enrolled. Patients were randomly assigned 1:1 to receive Denosumab 60 mg subcutaneously every 6 months or Alendronate (70 mg weekly) for 2 years...
November 4, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27812727/-atypical-subtrochanteric-femur-fracture-under-alendronate-therapy-in-spite-of-an-intramedullar-implant
#12
H-P Sobotta, T Gösling
There are a number of case reports about women undergoing long-term bisphosphonate therapy who have suffered an atypical subtrochanteric or femoral shaft fracture due to an inadequate trauma.The present case reports on a patient who underwent a subtrochanteric femur fracture with the inserted AO femur interlocking nail.
November 3, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27810280/-1-h-nmr-based-metabonomic-study-on-the-effects-of-epimedium-on-glucocorticoid-induced-osteoporosis
#13
Sina Pan, Ali Chen, Zhihui Han, Yaling Wang, Xin Lu, Yongxia Yang
Glucocorticoids are widely used in clinical practice for the treatment of many immune-mediated and inflammatory diseases, and glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. Epimedium is one of the most commonly used traditional Chinese medicines for treating osteoporosis. In the present study, we systematically analysed the metabonomic characteristics of GIO model rats and elucidated the therapeutic effect of Epimedium by using a (1)H NMR-based metabonomic approach in conjunction with multivariate data analysis...
October 14, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27807651/comparison-of-the-alendronate-and-irradiation-with-a-light-emitting-diode-led-on-murine-osteoclastogenesis
#14
Hong Moon Sohn, Youngjong Ko, Mineon Park, Bora Kim, Jung Eun Park, Donghwi Kim, Young Lae Moon, Wonbong Lim
Photomodulation therapy (PBMT) using light-emitting diode (LED) has been proposed as an alternative to conventional osteoporosis therapies. Our aim was to determine the effect of irradiation with a light-emitting diode on receptor activator of NF-κB ligand (RANKL)-mediated differentiation of mouse bone marrow macrophages into osteoclasts and compare it to alendronate treatment. The cells were irradiated with LED at 635±10 nm, 9-cm spot size, 5 mW/cm(2), and 18 J for 60 min/day in a CO2 incubator. The differentiation of irradiated and untreated RANKL-stimulated bone marrow macrophages into osteoclasts was evaluated by tartrate-resistant acid phosphatase (TRAP) staining and by molecular methods...
November 2, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27801641/a-systematic-review-and-economic-evaluation-of-bisphosphonates-for-the-prevention-of-fragility-fractures
#15
Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes
BACKGROUND: Fragility fractures are fractures that result from mechanical forces that would not ordinarily result in fracture. OBJECTIVES: To evaluate the clinical effectiveness and safety of bisphosphonates [alendronic acid (Fosamax(®) and Fosamax(®) Once Weekly, Merck Sharp & Dohme Ltd), risedronic acid (Actonel(®) and Actonel Once a Week(®), Warner Chilcott UK Ltd), ibandronic acid (Bonviva(®), Roche Products Ltd) and zoledronic acid (Aclasta(®), Novartis Pharmaceuticals UK Ltd)] for the prevention of fragility fracture and to assess their cost-effectiveness at varying levels of fracture risk...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27796444/effects-of-raloxifene-and-alendronate-on-non-enzymatic-collagen-cross-links-and-bone-strength-in-ovariectomized-rabbits-in-sequential-treatments-after-daily-human-parathyroid-hormone-1-34-administration
#16
S Kimura, M Saito, Y Kida, A Seki, Y Isaka, K Marumo
: This study investigated the effects of raloxifene and alendronate to follow parathyroid hormone (PTH) on bone collagen and biomechanical properties in ovariectomized rabbits. Sequential treatments of raloxifene and alendronate after hPTH(1-34) treatment improved biomechanical properties with and without bone collagen improvement, respectively. INTRODUCTION: The standard sequential treatment to follow human parathyroid hormone (hPTH) (1-34) therapy for osteoporosis has yet to be determined...
October 29, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27793710/enhanced-oral-delivery-of-alendronate-by-sucrose-fatty-acids-esters-in-rats-and-their-absorption-enhancing-mechanisms
#17
Tammam Alama, Hiroko Katayama, Sachiko Hirai, Shizuka Ono, Ayumi Kajiyama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Oral delivery is the most fascinating route for interminable drug remedy. However, the intestinal absorption of alendronate (ALN), a bisphosphonate drug after oral administration is very poor. Absorption enhancers, which help to achieve the efficiency-safety balance, are considered one of the most promising agents for the improvement the intestinal absorption of drugs. In the current study, we focused on using sucrose fatty acid esters (SEs) as promising absorption enhancers to enhance the intestinal absorption of alendronate using an in situ closed-loop method in rats...
October 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27789081/use-of-drugs-against-osteoporosis-in-the-baltic-countries-during-2010-2014
#18
Ott Laius, Katre Maasalu, Sulev Kõks, Aare Märtson
BACKGROUND AND OBJECTIVE: Osteoporosis is a major health threat nowadays. Aging of the population and changes in peoples' lifestyle result in a constant increase in the number of fractures all over the world. Our study aimed at describing the drug utilization pattern and choice of active substances of antiosteoporotic medicines in the Baltic countries. MATERIALS AND METHODS: Sales data of the antiosteoporotic medicines was obtained from the internet. These are available on the website of medicines regulatory agencies...
2016: Medicina
https://www.readbyqxmd.com/read/27781436/exploiting-the-metal-chelating-properties-of-the-drug-cargo-for-in-vivo-positron-emission-tomography-imaging-of-liposomal-nanomedicines
#19
Scott Edmonds, Alessia Volpe, Hilary Shmeeda, Ana C Parente-Pereira, Riya Radia, Julia Baguña-Torres, Istvan Szanda, Gregory W Severin, Lefteris Livieratos, Philip J Blower, John Maher, Gilbert O Fruhwirth, Alberto Gabizon, Rafael T M de Rosales
The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body imaging techniques such as positron emission tomography (PET). Thus, a broad method to radiolabel and track preformed nanomedicines such as liposomal drugs with PET radionuclides will have a wide impact in nanomedicine. Here, we introduce a simple and efficient PET radiolabeling method that exploits the metal-chelating properties of certain drugs (e.g., bisphosphonates such as alendronate and anthracyclines such as doxorubicin) and widely used ionophores to achieve excellent radiolabeling yields, purities, and stabilities with (89)Zr, (52)Mn, and (64)Cu, and without the requirement of modification of the nanomedicine components...
October 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/27779611/effects-of-alendronate-on-bone-remodeling-around-osseointegrated-implants-in-rats
#20
Kyung Chul Oh, Woojin Hwang, Young Bum Park, Jae Hoon Lee, Hong Seok Moon, Jee Hwan Kim
OBJECTIVE: To determine the effects of alendronate on bone remodeling around osseointegrated implants in rats. MATERIALS AND METHODS: The maxillary first molars were extracted from 36 male Sprague-Dawley rats, and replaced with customized implants. They were then administered twice-weekly subcutaneous injections of either alendronate (alendronate group) or saline (control group) after allowing a 4-week period for osseointegration. They were killed at 4, 8, or 12 weeks after the commencement of the injection protocol, and the implant sites were evaluated comprehensively by microcomputed tomographic, histologic, and biochemical assessments...
October 20, 2016: Implant Dentistry
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