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Alendronate

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https://www.readbyqxmd.com/read/28719844/phosphate-functionalized-4-4-armchair-cnts-as-novel-drug-delivery-systems-for-alendronate-and-etidronate-anti-osteoporosis-drugs
#1
Zahra Nikfar, Zahra Shariatinia
The ability of (4,4)-armchair CNT and its three phosphate functionalized forms (CNT-nH2PO4, n=1-3) were evaluated as novel drug delivery systems (DDSs) for the two commercially well-known anti-osteoporosis drugs namely alendronate (AL) and etidronate (ET). For this purpose, the DFT calculations were accomplished at both B3LYP and B3PW91 levels using 6-31g(d) basis set. The binding energy was increased by increasing number of H2PO4 moieties attached on the CNT with the most negative binding energy was measured for the carrier containing three phosphate groups...
July 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28715470/impairment-of-cold-injury-induced-muscle-regeneration-in-mice-receiving-a-combination-of-bone-fracture-and-alendronate-treatment
#2
Shigeo Kawada, Atsushi Harada, Naohiro Hashimoto
Alendronate, a nitrogen-containing bisphosphonate, is well established as a treatment for osteoporosis through regulation of osteoclast activity. Previously, the pharmacological effects of bisphosphonates on cells outside the bone environment have been considered irrelevant because bisphosphonates target bone. Here we show that administration of alendronate impairs muscle regeneration in mice after bone fracture. A series of injections of alendronate alone or bone fracture alone did not affect muscle regeneration induced by cold injury...
2017: PloS One
https://www.readbyqxmd.com/read/28715463/potassium-citrate-prevents-increased-osteoclastogenesis-resulting-from-acidic-conditions-implication-for-the-treatment-of-postmenopausal-bone-loss
#3
Donatella Granchi, Elena Torreggiani, Annamaria Massa, Renata Caudarella, Gemma Di Pompo, Nicola Baldini
The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the skeleton and the deterioration of bone microarchitecture. Alkalinization through supplementation with potassium citrate (K citrate) has been proposed to limit the osteopenia progression, even though its pharmacological activity in bone microenvironment is not well defined. We evaluated if K citrate was able to prevent the adverse effects that acidic milieu induces on bone cells...
2017: PloS One
https://www.readbyqxmd.com/read/28714038/one-and-two-year-persistence-with-different-anti-osteoporosis-medications-a-retrospective-cohort-study
#4
C Reyes, C Tebe, D Martinez-Laguna, M S Ali, A Soria-Castro, C Carbonell, D Prieto-Alhambra
Adherence to anti-osteoporosis medications is poor. We carried out a cohort study using a real-world population database to estimate the persistence of anti-osteoporosis drugs. Unadjusted 2-year persistence ranged from 10.3 to 45.4%. Denosumab users had a 40% lower risk of discontinuation at 2 years compared to alendronate users. PURPOSE: The purpose of this study was to estimate real-world persistence amongst incident users of anti-osteoporosis medications. METHODS: This is a retrospective cohort using data from anonymised records and dispensation data ( www...
July 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28704906/the-therapeutic-effects-of-combination-therapy-with-curcumin-and-alendronate-on-spine-fusion-surgery-in-the-ovariectomized-rats
#5
Dae-Chul Cho, Kyoungsu Ryu, Kyoung-Tae Kim, Joo-Kyung Sung
OBJECTIVE: The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. METHODS: Thirty-two female Sprague-Dawley rats (12 weeks old) underwent bilateral ovariectomy (OVX). Eight weeks after surgery, animals underwent intertransverse spine fusion at L4-5. The rats were randomly distributed amongst 4 groups; untreated OVX group, curcumin administered group, alendronate administered group, and the combination therapy group...
June 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28699744/design-synthesis-and-pharmacokinetics-of-a-bone-targeting-dual-action-prodrug-for-treatment-of-osteoporosis
#6
Haibo Xie, Gang Chen, Robert N Young
A dual-action bone-targeting prodrug has been designed, synthesized and evaluated for in vitro and in vivo metabolic stability and in vivo tissue distribution, and rates of release of the active constituents after binding to bones through the use of differentially double labelled derivatives. The conjugate (general structure 7) embodies the merger of a very potent and proven anabolic selective agonist of the prostaglandin EP4 receptor, compound 5, and alendronic acid, a potent inhibitor of bone resorption, optimally linked through a differentially hydrolyzable linker unit, N-4-carboxymethylphenyl-methyloxycarbonyl-leucinyl-argininyl-para-aminophenylmethylalcohol (Leu-Arg-PABA)...
July 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28699091/the-effects-of-ozone-application-on-genotoxic-damage-and-wound-healing-in-bisphosphonate-applied-human-gingival-fibroblast-cells
#7
Sıdıka Sinem Akdeniz, E Beyler, Y Korkmaz, E Yurtcu, U Ates, K Araz, F I Sahin, O Y Torun
OBJECTIVES: Medication-related osteonecrosis of the jaws (MRONJ) is an extremely therapy-resistant disease involving the jaws especially following bisphosphonate treatment. Bisphosphonates accumulate in bone in concentrations sufficient to be directly toxic to the oral epithelium. Current therapeutic options are inadequate for the prevention and treatment of MRONJ. The aim of this study was to investigate effects of ozone gas plasma therapy on wound healing in bisphosphonate-applied human fibroblasts...
July 11, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28698172/alendronate-may-cut-hip-fracture-risk-in-older-patients-taking-prednisolone
#8
Jacqui Wise
No abstract text is available yet for this article.
July 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28697254/association-between-alendronate-use-and-hip-fracture-risk-in-older-patients-using-oral-prednisolone
#9
Kristian F Axelsson, Anna G Nilsson, Hans Wedel, Dan Lundh, Mattias Lorentzon
Importance: Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids. Objective: To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects. Design, Setting, and Participants: Retrospective cohort study using a national database (N = 433 195) of patients aged 65 years or older undergoing a health evaluation (baseline) at Swedish health care facilities; 1802 patients who were prescribed alendronate after at least 3 months of oral prednisolone treatment (≥5 mg/d) were identified...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28694026/nano-technology-based-carriers-for-nitrogen-containing-bisphosphonates-delivery-as-sensitisers-of-%C3%AE-%C3%AE-t-cells-for-anticancer-immunotherapy
#10
Naomi O Hodgins, Julie Tzu-Wen Wang, Khuloud T Al-Jamal
Nitrogen containing bisphosphonates (N-BPs) including zoledronate (ZOL) and alendronate (ALD) inhibit farnesyl diphosphate synthase, and have been shown to have a cytotoxic affect against cancer cells as a monotherapy and to also sensitise tumour cells to destruction by γδ T cells. γδ T cells are a subset of human T lymphocytes and have a diverse range of roles in the immune system including the recognition and destruction of cancer cells. This property of γδ T cells can be harnessed for use in cancer immunotherapy through in vivo expansion or the adoptive transfer of ex vivo activated γδ T cells...
July 7, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28692499/would-be-prophylactic-administrations-of-low-concentration-of-alendronate-an-alternative-for-improving-the-craniofacial-bone-repair-a-preliminary-study-focused-in-the-period-of-cellular-differentiation-and-tissue-organization
#11
Isabella Göhringer, Carmem L Storrer Muller, Emanuelle Juliana Cunha, Giuliene Nunes De Souza Passoni, Juliana Souza Vieira, João Cesar Zielak, Rafaela Scariot, Tatiana Miranda Deliberador, Allan Fernando Giovanini
BACKGROUND: Alendronate (ALN) is a nitrogen-bisphosphonate that may induce an anabolic effect on craniofacial bone repair when administrated in low doses. Based on this premise, this study analyzed the influence of prophylactic low doses of ALN on bone healing in defects created in rabbit mandible. METHODS: A 5 × 2-mm diameter deep defect was created in the calvaria of 28 rabbits. Fourteen of these rabbits received previously 50 μg/kg of 1% sodium ALN for 4 weeks, while the other rabbits received only 0...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28688093/influence-of-bisphosphonates-on-the-adherence-and-metabolism-of-epithelial-cells-and-gingival-fibroblasts-to-titanium-surfaces
#12
Fernanda Gonçalves Basso, Taisa N Pansani, Diana G Soares, Lais M Cardoso, Josimeri Hebling, Carlos Alberto de Souza Costa
OBJECTIVES: To evaluate the effects of sodium alendronate (SA) and zoledronic acid (ZA), on the adhesion and metabolism of epithelial cells and gingival fibroblasts to titanium surfaces considering cell functions related to an effective mucosal barrier around the implant. MATERIALS AND METHODS: Cells were seeded onto titanium discs and incubated for 24 h. Then, serum-free DMEM containing selected bisphosphonates (0, 0.5, 1, or 5 μM) was added for 24 and 48 h...
July 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28687467/what-is-the-effect-of-anti-resorptive-drugs-ards-on-the-development-of-medication-related-osteonecrosis-of-the-jaw-mronj-in-osteoporosis-patients-a-systematic-review
#13
Suad Aljohani, Riham Fliefel, Jacob Ihbe, Jan Kühnisch, Michael Ehrenfeld, Sven Otto
PURPOSE: To conduct a systematic review of the literature to detect the effect of anti-resorptive drugs (ARDs) and their administration characteristics in the development of medication-related osteonecrosis of the jaw (MRONJ) in osteoporosis patients. METHODS: Systematic search in PubMed, Web of Sciences and Cochrane Library was performed for relevant studies to July 2016. Population variables (age, gender, comorbidities, medications, preceding events, number of patients with MRONJ), ARDs and clinical variables were abstracted independently from these articles...
June 3, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28685283/short-term-effects-of-extracorporeal-shock-wave-therapy-on-bone-mineral-density-in-postmenopausal-osteoporotic-patients
#14
L Shi, F Gao, W Sun, B Wang, W Guo, L Cheng, Z Li, W Wang
It has been proved that extracorporeal shock wave therapy (ESWT) could promote new bone formation. Therefore, we designed an experiment to test the efficiency of ESWT on BMD in postmenopausal osteoporotic patients. The results showed that ESWT could effectively improve the local bone mass of the treated bone area within a short duration. INTRODUCTION: This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD). METHODS: A total of 64 postmenopausal osteoporotic patients were recruited and randomized into 3 groups in 2015...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28682411/coordination-self-assembly-of-platinum-bisphosphonate-polymer-metal-complex-nanoparticles-for-cisplatin-delivery-and-effective-cancer-therapy
#15
Yanjuan Huang, Yuanfeng He, Ziyuan Huang, Yali Jiang, Weijing Chu, Xiaoqi Sun, Liangfeng Huang, Chunshun Zhao
Cisplatin (CDDP) is a potent anti-carcinogen that is widely used for various solid tumors; however, its clinical application is limited by its severe nephrotoxicity. Novel platinum-bisphosphonate polymer-metal complex nanoparticles (Pt-bp NPs), based on platinum-bisphosphonate coordination, have been established. Three polymer carriers bearing alendronate (ALN) ligands, while containing different lengths of alkyl hydrophobic chains, were synthesized. Their structures were characterized by (1)H NMR, (31)P NMR and FTIR...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28678950/effect-of-1-sodium-alendronate-in-the-non-surgical-treatment-of-periodontal-intraosseous-defects-a-6-month-clinical-trial
#16
Bernardo Carvalho Dutra, Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Flavio Ricardo Manzi, Sheila Cavalca Cortelli, Luís Otávio de Miranda Cota, Fernando Oliveira Costa
Background and objectives: Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and Methods: Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28678942/role-of-1-alendronate-gel-as-adjunct-to-mechanical-therapy-in-the-treatment-of-chronic-periodontitis-among-smokers
#17
Anuj Sharma, Achala Raman, Avani Raju Pradeep
Objective: Alendronate (ALN) inhibits osteoclastic bone resorption and triggers osteostimulative properties both in vivo and in vitro, as shown by increase in matrix formation. This study aimed to explore the efficacy of 1% ALN gel as local drug delivery (LDD) in adjunct to scaling and root planing (SRP) for the treatment of chronic periodontitis among smokers. Material and Methods: 75 intrabony defects were treated in 46 male smokers either with 1% ALN gel or placebo gel...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28678853/randomized-clinical-trial-comparing-efficacy-and-safety-of-brand-versus-generic-alendronate-bonmax%C3%A2-for-osteoporosis-treatment
#18
Aasis Unnanuntana, Atthakorn Jarusriwanna, Panupan Songcharoen
INTRODUCTION: Although the same efficacy and tolerability are anticipated due to both drugs containing the same active ingredients, comparative studies between brand and generic alendronate are limited. Accordingly, the objective of this study was to compare efficacy and safety between brand alendronate and a recently introduced generic alendronate drug. METHODS: A total of 140 postmenopausal women or men aged older than 50 years who met the indications for osteoporosis treatment were randomized to receive either generic (Bonmax®) or brand alendronate (Fosamax®) 70 mg/week over a 12-month period during the May 2014 to June 2015 study period...
2017: PloS One
https://www.readbyqxmd.com/read/28669103/disease-modifying-anti-rheumatic-drug-effect-of-denosumab-on-radiographic-progression-in-rheumatoid-arthritis-a-systematic-review-of-the-literature
#19
Gonçalo Boleto, Moustapha Dramé, Isabelle Lambrecht, Jean-Paul Eschard, Jean-Hugues Salmon
The aim of this study was to evaluate the structural effect of denosumab on patients with rheumatoid arthritis (RA). We performed a systematic review of the literature in the following databases: PubMed, Cochrane, Web of Science, ClinicalTrials.gov , and the WHO International Clinical Trials Registry Platform. All studies evaluating the structural effect of denosumab on RA and meeting predefined criteria were included. Data regarding disease activity, progression of joint damage, joint space narrowing, and safety were recorded...
July 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28665545/inhibition-of-mevalonate-pathway-prevents-ischemia-induced-cardiac-dysfunction-in-rats-via-rhoa-independent-signaling-pathway
#20
Ying Yang, Xiqing Rong, Xue Lv, Wenbing Jiang, Yuan Yang, Dongwu Lai, Shiming Xu, Guosheng Fu
AIM: We previously demonstrated that anoxia-mediated Ca(2+) handling dysfunction could be ameliorated through inhibition of mevalonate pathway via RhoA- and Ras-related mechanisms in H9c2 cells. In this study, we further explored whether inhibition of mevalonate pathway is associated with cardiac remodeling and dysfunction in ischemic cardiomyopathy, and discuss the possible role of Ras, Rac and RhoA in cardiac dysfunction. METHODS: We investigated the role of mevalonate pathway in cardiac remodeling and cardiomyocyte Ca(2+) handling proteins expression in a rat model of cardiac dysfunction due to myocardial infarction (MI)...
June 30, 2017: Cardiovascular Therapeutics
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