Vetra Markeviciute, Manoj Puthia, Linnea Arvidsson, Yang Liu, Elin Törnquist, Alessandro Tengattini, Jintian Huang, Yiguang Bai, Corina Vater, Robertas Petrolis, Stefan Zwingenberger, Algimantas Krisciukaitis, Alfredas Smailys, Saulius Lukosevicius, Mindaugas Stravinskas, Hanna Isaksson, Sarunas Tarasevicius, Lars Lidgren, Magnus Tägil, Deepak Bushan Raina
Fracture fixation in an ageing population is challenging and fixation failure increases mortality and societal costs. We report a novel fracture fixation treatment by applying a hydroxyapatite (HA) based biomaterial at the bone-implant interface and biologically activating the biomaterial by systemic administration of a bisphosphonate (zoledronic acid, ZA). We first used an animal model of implant integration and applied a calcium sulphate (CaS)/HA biomaterial around a metallic screw in the tibia of osteoporotic rats...
March 13, 2024: Acta Biomaterialia