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https://www.readbyqxmd.com/read/27801641/a-systematic-review-and-economic-evaluation-of-bisphosphonates-for-the-prevention-of-fragility-fractures
#1
Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes
BACKGROUND: Fragility fractures are fractures that result from mechanical forces that would not ordinarily result in fracture. OBJECTIVES: To evaluate the clinical effectiveness and safety of bisphosphonates [alendronic acid (Fosamax(®) and Fosamax(®) Once Weekly, Merck Sharp & Dohme Ltd), risedronic acid (Actonel(®) and Actonel Once a Week(®), Warner Chilcott UK Ltd), ibandronic acid (Bonviva(®), Roche Products Ltd) and zoledronic acid (Aclasta(®), Novartis Pharmaceuticals UK Ltd)] for the prevention of fragility fracture and to assess their cost-effectiveness at varying levels of fracture risk...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26229930/use-of-risedronate-for-consolidation-and-callus-formation-in-colles-fractures-in-postmenopausal-women-solid-study
#2
Lindomar Guimarães Oliveira, Sérgio Ragi Eis, Henrique Mota Neto, Frederico Barra de Moraes, Luiz Antônio Silveira Simões Pires, José Wanderley Vasconcelos
OBJECTIVE: This open, randomized and blinded parallel-group multicenter study evaluated the efficacy of Actonel(®) (35 mg) plus calcium/vitamin D versus calcium/vitamin D alone for preserving bone mineral density (BMD) in postmenopausal women with Colles fractures. METHODS: Patients with a Colles fracture for seven days were randomized to receive either Actonel(®) (35 mg) once a week plus calcium/vitamin D (ACD group) or calcium/vitamin D alone (CD group). The patients were evaluated after 90 and 180 days of treatment...
May 2015: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/24534414/systematic-review-of-the-use-of-bone-turnover-markers-for-monitoring-the-response-to-osteoporosis-treatment-the-secondary-prevention-of-fractures-and-primary-prevention-of-fractures-in-high-risk-groups
#3
REVIEW
Jane Burch, Stephen Rice, Huiqin Yang, Aileen Neilson, Lisa Stirk, Roger Francis, Paul Holloway, Peter Selby, Dawn Craig
BACKGROUND: There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations. Bone turnover markers have advantages over DXA as they are non-invasive, relatively cheap and can detect changes in bone turnover rates earlier. However, they do have disadvantages, particularly high within- and between-patient variability...
February 2014: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/23644167/late-onset-psychosis-and-risedronate-treatment-for-osteoporosis
#4
Shmuel Hirschmann, Anatoly Gibel, Irena Tsvelikhovsky, Alexander Lisker
As women age and enter menopause, they are sometimes more susceptible than men to certain physical and mental disorders such as osteoporosis and late-onset schizophrenia. Risedronate (Actonel©) is a bisphosphonate used for the treatment of osteopenia. Early initiation of pharmacotherapy for osteopenia is recommended to prevent greater bone loss. The most common side effects of risedronate include fever and flu-like symptoms, hypocalcemia, bone and joint pain, peripheral edema, fatigue, change in bowel movements, osteonecrosis of the jaw, and atrial fibrillation...
April 2015: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/22479027/use-of-oral-bisphosphonates-by-older-adults-with-fractures-and-impaired-renal-function
#5
Cheryl A Sadowski, Tara Spencer, Nese Yuksel
BACKGROUND: The manufacturers of oral bisphosphonates (alendronate, risedronate) recommend avoiding use of these drugs in patients with renal impairment. However, many patients who have osteoporosis or who are at risk of fracture are elderly and may have renal impairment. This situation poses a quandary for clinicians in deciding how best to manage osteoporosis in this high-risk population. OBJECTIVE: To synthesize published evidence regarding the use and safety of oral bisphosphonates for patients with impaired renal function...
January 2011: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/21781014/in-vitro-disintegration-studies-of-weekly-generic-and-branded-risedronate-sodium-formulations-available-in-canada
#6
COMPARATIVE STUDY
A D Walker, J D Adachi
OBJECTIVE: The aim of this study was to evaluate the in vitro disintegration of the five newly available Canadian generic risedronate 35 mg tablets compared to the innovator (branded) product, ACTONEL * *ACTONEL is a registered trade name of Warner Chilcott Company, LLC. (risedronate sodium) 35 mg. RESEARCH DESIGN AND METHODS: Tablets were inspected for colour and appearance. Disintegration times were determined using United States Pharmacopeia 33 (USP33-NF 28) methods...
September 2011: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/21312265/bone-turnover-markers-and-bone-mineral-density-response-with-risedronate-therapy-relationship-with-fracture-risk-and-patient-adherence
#7
RANDOMIZED CONTROLLED TRIAL
Richard Eastell, Bernard Vrijens, David L Cahall, Johann D Ringe, Patrick Garnero, Nelson B Watts
Surrogate markers of fracture risk--bone turnover markers (BTMs) and bone mineral density (BMD)--can be used to monitor treatment response. We assessed whether changes in these markers greater than the least significant change (LSC) were associated with fracture risk reduction and greater adherence. This secondary analysis of the Improving Measurements of Persistence on ACtonel Treatment (IMPACT) study--a multinational prospective, open-label, cluster-randomized study of postmenopausal women on oral risedronate 5 mg/d for 52 weeks-assessed adherence by electronic monitors...
July 2011: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/20141367/response-to-oral-bisphosphonates-in-subgroups-of-younger-and-older-postmenopausal-women
#8
RANDOMIZED CONTROLLED TRIAL
Dale W Stovall, Mary K Beard, Suzanne Barbier, Erluo Chen, Elizabeth Rosenberg, Anne E de Papp
BACKGROUND: Although the effects of bisphosphonates in bone are known for postmenopausal women, it is not known if younger postmenopausal women have a similar response. Furthermore, it is not known if the effects of alendronate and risedronate differ in postmenopausal women in regard to age, specifically in women at or younger than the mean age of natural menopause. Our aim was to examine the effects of two oral bisphosphonates in postmenopausal women by age. METHODS: This was a post-hoc analysis of postmenopausal women <55 or > or =55 years old with low bone mineral density (BMD), randomized to once weekly alendronate 70 mg or risedronate 35 mg for 1 year with 1-year extensions in U...
March 2010: Journal of Women's Health
https://www.readbyqxmd.com/read/19826634/profound-muscle-weakness-and-pain-after-one-dose-of-actonel
#9
Irina Badayan, Merit E Cudkowicz
The World Health Organization (WHO) defines osteopenia as a bone density between 1 and 2.5 standard deviation (SD) below the bone density of a normal young adult Iqbal 2000. Osteoporosis is defined as 2.5 SD or more below that reference point Iqbal 2000. Bisphosphonates are a group of medications used to treat osteoporosis, Padget's disease of bone, and osteopenia. We report a woman who developed profound muscle weakness and pain after one dose of Risedronate (Actonel).
2009: Case Reports in Medicine
https://www.readbyqxmd.com/read/19584189/antiresorptive-effects-of-phytoestrogen-supplements-compared-with-estradiol-or-risedronate-in-postmenopausal-women-using-41-ca-methodology
#10
RANDOMIZED CONTROLLED TRIAL
C M Weaver, B R Martin, G S Jackson, G P McCabe, J R Nolan, L D McCabe, S Barnes, S Reinwald, M E Boris, M Peacock
INTRODUCTION: Reduction of ovarian estrogen secretion at menopause increases net bone resorption and leads to bone loss. Isoflavones have been reported to protect bone from estrogen deficiency, but their modest effects on bone resorption have been difficult to measure with traditional analytical methods. METHODS: In this randomized-order, crossover, blinded trial in 11 healthy postmenopausal women, we compared four commercial sources of isoflavones from soy cotyledon, soy germ, kudzu, and red clover and a positive control of oral 1 mg estradiol combined with 2...
October 2009: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/19430791/differences-in-persistence-safety-and-efficacy-of-generic-and-original-branded-once-weekly-bisphosphonates-in-patients-with-postmenopausal-osteoporosis-1-year-results-of-a-retrospective-patient-chart-review-analysis
#11
COMPARATIVE STUDY
Johann D Ringe, Gerd Möller
The objective of this study was to compare the changes on bone mineral density, and the effects on persistence and adverse events in patients treated for postmenopausal osteoporosis with generic alendronate or with branded alendronate (Fosamax®) or branded risedronate (Actonel®) once weekly. In this retrospective patient chart analysis, we reviewed the 1-year observational treatment results for 186 women (ITT population) with postmenopausal osteoporosis. Patients from our outpatient department, who had started with once-weekly bisphosphonate therapy between 36 and at least 12 months before this chart review, were included in this comparative three-arm study according to their treatment: A, Generic Alendonate 70 mg products; B, Branded Alendronate (Fosamax®) 70 mg once weekly and C, Branded Risedronate (Actonel®) 35 mg once weekly...
December 2009: Rheumatology International
https://www.readbyqxmd.com/read/19024283/-differences-among-bisfosfonates-specificity-of-risedronate-actonel
#12
Zlatko Giljević
Bisphosphonates, a gold standard in therapeutic options for the management of osteoporosis, inhibit bone resorption with relatively few side effects. As a result, they are widely used for the prevention and treatment of osteoporosis. There are clear biochemical and pharmacological differences among bisfosfonates group. Risedronate has moderate mineral binding and has a higher inhibition of a key branch-point enzyme famesyl pyrophosphate synthase (FPPS) in the mevalonate pathway. Risedronate (Actonel) prevents vertebral and nonvertebral fractures as early as at 6 months of treatment...
2008: Reumatizam
https://www.readbyqxmd.com/read/18830555/dxa-based-hip-structural-analysis-of-once-weekly-bisphosphonate-treated-postmenopausal-women-with-low-bone-mass
#13
S L Bonnick, T J Beck, F Cosman, M C Hochberg, H Wang, A E de Papp
SUMMARY: DXA-based hip structural analysis from 947 individuals completing two large osteoporosis clinical trials was pooled and analyzed. Treatment with once-weekly (OW) ALN or OW RIS resulted in significant improvements from baseline in geometric parameters at all three HSA ROIs. Improvements were generally greater with OW ALN than OW RIS. INTRODUCTION: BMD can be altered by changes in distribution and quantity of bone and changes in mineralization. These effects cannot be distinguished with conventional measurements of BMD...
June 2009: Osteoporosis International
https://www.readbyqxmd.com/read/18772843/monthly-risedronate-actonel-for-postmenopausal-osteoporosis
#14
COMPARATIVE STUDY
(no author information available yet)
No abstract text is available yet for this article.
September 8, 2008: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/18450246/the-utilisation-and-expenditure-of-medicines-for-the-prophylaxis-and-treatment-of-osteoporosis
#15
B McGowan, K Bennett, M Barry, M Canny
The elderly population represent the fastest growing age-group and the incidence of osteoporotic related fractures is likely to increase with continued ageing of the population. This study determined the prescribing patterns on the Health Services Executive's (HSE) Primary Care Reimbursement Services Scheme (HSE-PCRS) of medicines dispensed for the prophylaxis and treatment of osteoporosis in Ireland. The HSE - PCRS prescription databases were analysed for the years 2004/2005. Approximately 65% of patients (total 60,000) were dispensed either Alendronate (Fosamax once weekly) or Risedronate (Actonel once weekly)...
February 2008: Irish Medical Journal
https://www.readbyqxmd.com/read/18351152/-risedronate-actonel-from-randomized-clinical-trials-to-real-life
#16
REVIEW
Branimir Anić
No abstract text is available yet for this article.
2007: Reumatizam
https://www.readbyqxmd.com/read/18324951/a-comparison-of-the-effect-of-alendronate-and-risedronate-on-bone-mineral-density-in-postmenopausal-women-with-osteoporosis-24-month-results-from-facts-international
#17
RANDOMIZED CONTROLLED TRIAL
D M Reid, D Hosking, D Kendler, M L Brandi, J D Wark, J F Marques-Neto, G Weryha, N Verbruggen, C M Hustad, E M Mahlis, M E Melton
OBJECTIVES: To compare alendronate 70 mg once weekly (OW) with risedronate 35 mg OW with respect to change in bone mineral density (BMD), biochemical markers and upper gastrointestinal (UGI) tolerability over 24 months. METHODS: This was a 12-month extension to the Fosamax Actonel Comparison Trial international study (FACTS). Postmenopausal women with osteoporosis randomly assigned to either alendronate 70 mg OW or risedronate 35 mg OW for the 12-month base study continued taking the same double-blind study medication...
April 2008: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/17580558/-treatment-of-osteoporosis-by-risedronate-speed-efficacy-and-safety
#18
REVIEW
Zlatko Giljević, Tonko Vlak
Risedronate (Actonel 35 mg), which was promoted in Croatia a few months ago, is the latest (III) generation of bisphosphonates, the most efficient anti-resorption drugs that inhibit osteoclast-mediated bone resorption and change the bone metabolism. The effect of risedronate is 10 times stronger than that of alendronate, and 10.000 times stronger than that of etidronate. The bone turnover is reduced while the osteoblast activity and bone mineralisation are preserved. Decreases in biochemical markers of bone turnover were observed as soon as within 1 month and reached a maximum in 3-6 months of Actonel 35 mg application once a week or 5 mg a day...
2006: Reumatizam
https://www.readbyqxmd.com/read/17244788/effect-of-monitoring-bone-turnover-markers-on-persistence-with-risedronate-treatment-of-postmenopausal-osteoporosis
#19
RANDOMIZED CONTROLLED TRIAL
Pierre D Delmas, Bernard Vrijens, Richard Eastell, Christian Roux, Huibert A P Pols, Johann D Ringe, Andreas Grauer, David Cahall, Nelson B Watts et al.
CONTEXT: Persistence with osteoporosis treatment is poor but is important for maximum benefit. OBJECTIVE: The objective of the study was to assess the impact of physician reinforcement using bone turnover markers (BTMs) on persistence with risedronate treatment. DESIGN AND SETTING: This was a 1-yr multinational prospective, open-label, blinded study in 171 osteoporosis centers in 21 countries. PATIENTS: A total of 2382 postmenopausal women (65-80 yr old) with spine/hip T-score -2...
April 2007: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/17163237/alendronic-acid-produces-greater-effects-than-risedronic-acid-on-bone-density-and-turnover-in-postmenopausal-women-with-osteoporosis-results-of-facts-international
#20
RANDOMIZED CONTROLLED TRIAL
David M Reid, David Hosking, David Kendler, Maria L Brandi, John D Wark, Georges Weryha, João F Marques-Neto, Keavy A Gaines, Nadia Verbruggen, Mary E Melton
BACKGROUND: The objective of the study was to evaluate the effects of alendronic acid once weekly relative to risedronic acid once weekly on bone mineral density (BMD), markers of bone turnover and tolerability in the treatment of osteoporosis in postmenopausal women. METHODS: This was a randomised, double-masked, double-dummy multicentre international study (75 centres in 27 countries in Europe, the Americas and Asia-Pacific). A total of 1303 women were screened and 936 with low bone density (T-score < or = -2...
2006: Clinical Drug Investigation
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