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Vania Teixeira, Marcelo Fernández, Natalia Oddone, Xiuli Zhang, Fabio Gallazzi, Hugo Cerecetto, Juan Pablo Gambini, Williams Porcal, Pablo Cabral, Thomas P Quinn
BACKGROUND: Lactam cyclized alpha-melanocyte stimulating hormone (α-MSH) analogues exhibit high stability and affinity for the MC1-R receptors over expressed in melanoma cells. Recently, we reported a novel <sup>99m</sup>Tc-HYNIC-cycMSH<sub>4-13</sub> analogue with the HYNIC chelator directly attached to the lactam cyclized ring. OBJECTIVE: In this study we proposed the introduction of a 6-aminohexanoic acid (Ahx) linker between the HYNIC chelator and lactam cyclized peptide cycMSH4-13 to reduce steric hindrance and improve the melanoma targeting and imaging proprieties of the radiolabeled peptide...
December 6, 2016: Anti-cancer Agents in Medicinal Chemistry
Woosuk Chung, Min Jeong Ryu, Jun Young Heo, Soomin Lee, Seunghwan Yoon, Haram Park, Sangil Park, Yangsik Kim, Yoon Hee Kim, Seok Hwa Yoon, Yong Sup Shin, Won Hyung Lee, Xianshu Ju, Gi Ryang Kweon, Youngkwon Ko
BACKGROUND: Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of sevoflurane on mitochondrial function were also assessed to further understand the mechanism behind spinogenesis. METHODS: Postnatal day 16 to 17 mice were exposed to sevoflurane (2...
December 6, 2016: Anesthesiology
Han Na Suh, Sohee Jun, Ah-Young Oh, Mrinal Srivastava, Sunhye Lee, Cullen M Taniguchi, Songlin Zhang, Won Sup Lee, Junjie Chen, Bum-Joon Park, Jae-Il Park
Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancreatic intraepithelial neoplasia, the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient samples...
December 6, 2016: Scientific Reports
Myoung Sup Shim, Keun-Young Kim, Won-Kyu Ju
Glaucoma is characterized by a slow and progressive degeneration of optic nerve, including retinal ganglion cell (RGC) axons in the optic nerve head (ONH), leading to visual impairment. Despite the high prevalence, the biological basis of glaucoma pathogenesis still is not yet fully understood, and the factors contributing to its progression are currently not well characterized. Intraocular pressure (IOP) is the only modifiable risk factor, and reduction of IOP is the standard treatment for glaucoma. However, lowering IOP itself is not always effective for preserving visual function in patients with primary open-angle glaucoma...
December 5, 2016: BMB Reports
Dong Sup Hwang, Hyo Bum Kwak, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Eun Sang Ji, Hyun Hee Choi, Oh Young Kwon
PURPOSE: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice. METHODS: The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2'-deoxyuridine immunofluorescence was used to assess neurogenesis...
November 2016: International Neurourology Journal
Sae-Kwang Ku, Jongdoo Kim, Sang Chan Kim, Jong-Sup Bae
Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Dabrafenib (DAB) is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. However, little is known about the effects of DAB on EPCR shedding. We investigated this issue by monitoring the effects of DAB on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-α-, interleukin (IL)-1β-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs), and cecal ligation and puncture (CLP)-mediated EPCR shedding in mice and underlying mechanism...
December 1, 2016: Archives of Pharmacal Research
Vivek Verma, Shifeng Chen, Sumin Zhou, Charles A Enke, Andrew O Wahl
PURPOSE: Using high-quality CT-on-rails imaging, the daily motion of the prostate bed clinical target volume (PB-CTV) based on consensus Radiation Therapy Oncology Group (RTOG) definitions (instead of surgical clips/fiducials) was studied. It was assessed whether PB motion in the superior portion of PB-CTV (SUP-CTV) differed from the inferior PB-CTV (INF-CTV). PATIENTS AND METHODS: Eight pT2-3bN0-1M0 patients underwent postprostatectomy intensity-modulated radiotherapy, totaling 300 fractions...
December 1, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Min-Sup Shin, Jayun Choi, Ryu-Yeon Ahn, Dong-Young Lee, Jun-Soo Kwon
OBJECTIVE: The aim of this study was to examine the concurrent validity of a newly developed computerized memory diagnostic system (MDS) with the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K). METHODS: Subtests of the MDS and CERAD-K, including the auditory-verbal, visuo-spatial, and working memory tests, were administered to 43 adults aged 60 to 74 years. We calculated the correlations between the subtest scores of the MDS and CERAD-K to examine the concurrent validity of the MDS...
November 2016: Psychiatry Investigation
Il-Sup Kim, Young-Saeng Kim, Yul-Ho Kim, Ae Kyung Park, Han-Woo Kim, Jun-Hyuck Lee, Ho-Sung Yoon
[This corrects the article DOI: 10.1371/journal.pone.0158841.].
2016: PloS One
Ramon Springer, Byoung Yeop Kang, Raju Lampande, Dae Hyun Ahn, Simone Lenk, Sebastian Reineke, Jang Hyuk Kwon
This paper demonstrates 2-stack and 3-stack white organic light-emitting diodes (WOLEDs) with fluorescent blue and phosphorescent yellow emissive units. The 2-stack and 3-stack WOLED comprises blue-yellow and blue-blue-yellow (blue-yellow-blue) combinations. The position of the yellow emitter and possible cavity lengths in different stack architectures are theoretically and experimentally investigated to reach Commission Internationale de L'Eclairage (CIE) coordinates of near (0.333/0.333). Here, a maximum external quantum efficiency (EQE) of 23...
November 28, 2016: Optics Express
S Ter-Avetisyan, A Andreev, K Platonov, J H Sung, S K Lee, H W Lee, J Y Yoo, P K Singh, H Ahmed, C Scullion, K F Kakolee, T W Jeong, P Hadjisolomou, M Borghesi
A significant level of back reflected laser energy was measured during the interaction of ultra-short, high contrast PW laser pulses with solid targets at 30° incidence. 2D PIC simulations carried out for the experimental conditions show that at the laser-target interface a dynamic regular structure is generated during the interaction, which acts as a grating (quasi-grating) and reflects back a significant amount of incident laser energy. With increasing laser intensity above 10<sup>18</sup> W/cm<sup>2</sup> the back reflected fraction increases due to the growth of the surface modulation to larger amplitudes...
November 28, 2016: Optics Express
Yoon-Seok Lee, Sang Min Lee, Heonoh Kim, Han Seb Moon
We report a bright photon-pair source with a coincidence counting rate per input power (cps/mW) of tens of thousands, obtained via spontaneous four-wave mixing from a Doppler-broadened atomic ensemble of the 5S<sub>1/2</sub>-5P<sub>3/2</sub>-5D<sub>5/2</sub> transition of <sup>87</sup>Rb. The photon-pair generation rate is enhanced by the two-photon coherence contributions from almost all the atomic velocity groups in the Doppler-broadened ladder-type atomic system...
November 28, 2016: Optics Express
Isaac Trumper, Heejoo Choi, Dae Wook Kim
An instantaneous phase shifting deflectometry measurement method is presented and implemented by measuring a time varying deformable mirror with an iPhone <sup>®</sup> 6. The instantaneous method is based on multiplexing phase shifted fringe patterns with color, and decomposing them in x and y using Fourier techniques. Along with experimental data showing the capabilities of the instantaneous deflectometry system, a quantitative comparison with the Fourier transform profilometry method, which is a distinct phase measuring method from the phase shifting approach, is presented...
November 28, 2016: Optics Express
Jen-Hao Rick Chang, B V K Vijaya Kumar, Aswin C Sankaranarayanan
Projectors create grayscale images by outputting a series of bitplanes or binary images within a short time period. While this technique works well for projecting low bit-depth (8-bit) images, it becomes infeasible for high bit-depth (say, 16-bit) projection - a capability that is increasingly desirable in many applications including cinemas and gaming. Existing designs for high bit-depth projection rely on multiple spatial light modulators and, as a consequence, their costs and complexities are usually far beyond the average consumer...
November 28, 2016: Optics Express
Baolai Yang, Hanwei Zhang, Chen Shi, Xiaolin Wang, Pu Zhou, Xiaojun Xu, Jinbao Chen, Zejin Liu, Qisheng Lu
Transverse mode instability (TMI) is one of the main limiting factors in kW-level fiber lasers. Unlike fiber amplifiers, TMI in fiber laser oscillators attracts less attention from researchers. In this work, we construct an all-fiber ytterbium-doped laser oscillator and investigate the performance in co-pumping and bidirectional-pumping configurations, respectively. In the co-pumping scheme, TMI occurs at ~1.6kW and restricts further output power scaling. Different from the characteristic of dynamic TMI in fiber amplifiers, quasi-static TMI is observed in the laser oscillator...
November 28, 2016: Optics Express
Joel Carpenter, Benjamin J Eggleton, Jochen Schröder
We demonstrate polarization-resolved frequency domain cross-correlated (C<sup>2</sup>) imaging to characterize a 5m length of hollow-core photonic bandgap fiber. We produce a spectrogram of the fiber response to investigate the spatial, polarization, spectral, and temporal behavior. We then show how this temporally-resolved technique can be used to characterize multiple fiber launch conditions simultaneously by assigning each a unique time delay.
November 28, 2016: Optics Express
Jun Yang, Daniel A Nolan
We propose two new methods to measure principal modes, or Eisenbud-Wigner-Smith eigenstates in optically scattering medium. Both methods use similar techniques as in quantum state tomography, and are based on direct measurement of temporal delays. The first method requires N<sup>2</sup> different input launching conditions, and only the mean signal delay of these input states are needed to obtain full information of the principal modes. When the mode delay differences are large and all modes are non-degenerate, a second method can be used, which only requires 3N - 2 input launching conditions...
November 28, 2016: Optics Express
Ren-Chao Jin, Jie Li, Ying-Hua Wang, Ming-Jie Zhu, Jia-Qi Li, Zheng-Gao Dong
Optical forces can be enhanced by surface plasmon resonances with various interesting characteristics. Here, we numerically calculated the optical forces enhanced by a new kind of toroidal dipolar resonance in a double-disk metastructure. The results show that this kind of optical force is competitive with ordinary plasmonic forces and typically can reach-182.5pNμm<sup>2</sup>mW<sup>-1</sup>. Influences of geometric parameters are discussed for the enhancement characteristic of optical force...
November 28, 2016: Optics Express
Xiutao Lou, Tie Zhang, Hongze Lin, Shiyi Gao, Lianjie Xu, Junnan Wang, Li Wan, Sailing He
We demonstrate a second-harmonic-generation (SHG) based method for the detection of gaseous elemental mercury by using a newly available green diode laser. Multimode ultraviolet radiation at 253.7 nm is generated through a process of SHG. Correlation spectroscopy is introduced into the scheme to guarantee the measurement accuracy. The limit of detection achieved is 0.6 μg/m<sup>3</sup> (0.07 ppb) for 1-m pathlength and 10-s integration time. The measurement accuracy is estimated to be 1.2%. The linear response range is estimated to be 0~60 μg/m<sup>2</sup> (6...
November 28, 2016: Optics Express
Jake Fontana, Melissa Maldonado, Nicholas Charipar, Scott A Trammell, Rafaela Nita, Jawad Naciri, Alberto Pique, Banahalli Ratna, Anderson S L Gomes
We created centimeter-scale area metasurfaces consisting of a quasi-hexagonally close packed monolayer of gold nanospheres capped with alkanethiol ligands on glass substrates using a directed self-assembly approach. We experimentally characterized the morphology and the linear and nonlinear optical properties of metasurfaces. We show these metasurfaces, with interparticle gaps of 0.6 nm, are modeled well using a classical (without charge transfer) description. We find a large dispersion of linear refractive index, ranging from values less than vacuum, 0...
November 28, 2016: Optics Express
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