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https://www.readbyqxmd.com/read/28227778/hybrid-automata-models-of-cardiac-ventricular-electrophysiology-for-real-time-computational-applications
#1
Sidharta Andalam, Harshavardhan Ramanna, Avinash Malik, Parthasarathi Roop, Nitish Patel, Mark L Trew, Sidharta Andalam, Harshavardhan Ramanna, Avinash Malik, Parthasarathi Roop, Nitish Patel, Mark L Trew, Nitish Patel, Avinash Malik, Parthasarathi Roop, Harshavardhan Ramanna, Mark L Trew, Sidharta Andalam
Virtual heart models have been proposed for closed loop validation of safety-critical embedded medical devices, such as pacemakers. These models must react in real-time to off-the-shelf medical devices. Real-time performance can be obtained by implementing models in computer hardware, and methods of compiling classes of Hybrid Automata (HA) onto FPGA have been developed. Models of ventricular cardiac cell electrophysiology have been described using HA which capture the complex nonlinear behavior of biological systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227719/a-telepresence-wheelchair-using-cellular-network-infrastructure-in-outdoor-environments
#2
Van Kha Ly Ha, Tuan Nghia Nguyen, Hung T Nguyen, Van Kha Ly Ha, Tuan Nghia Nguyen, Hung T Nguyen, Van Kha Ly Ha, Tuan Nghia Nguyen, Hung T Nguyen
Mobile wireless network technology has grown rapidly over the past decade with emerging applications and services. Particularly, the fourth generation (4G) cellular network has acted as a bridge between telecommunication technology and daily life applications. In this paper, we present an investigation into a telepresence wheelchair in outdoor environments employing cellular network infrastructure instead of using local wireless networks in indoor environments. Experiments were carried out to demonstrate remote interaction and control from a long distance and across countries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227326/detection-of-binaural-interaction-in-free-field-evoked-auditory-brainstem-responses-by-time-scale-representations
#3
Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Horst Hessel, Erik Schebsdat, Harald Seidler, Daniel J Strauss
The so called β-wave of the binaural interaction component (BIC) in auditory brainstem responses (ABR) has been shown to be an objective measure for binaural interaction (BI). This component is the arithmetical difference between the sum of the monaurally evoked ABRs and the binaurally evoked ABR. Unfortunately, these neural responses are known to be very fragile and as a result the calculated BIC. An additional issue is, that the findings of this measurement are predominantly needed in people with hearing loss who may use hearing devices like hearing aids (HA) or cochlear implants (CI), thus they are not able to use headphones (like in conventional ABR measurements) during the detection of possible BI...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226415/topographical-pressure-pain-sensitivity-maps-of-the-temporalis-muscle-in-people-with-frequent-episodic-and-chronic-tension-type-headache
#4
María Palacios Ceña, Matteo Castaldo, Kelun Wang, Pascal Madeleine, Ángel L Guerrero, Lars Arendt-Nielsen, César Fernández de Las Peñas
BACKGROUND: Previous pilot studies suggest the presence of heterogeneous sensitivity to pressure in primary headaches without considering the frequency of headache episodes. OBJECTIVE: To investigate the differences in topographical pressure pain sensitivity maps in the temporalis muscle between individuals with frequent episodic (FETTH) and chronic (CTTH) tension-type headache by controlling the presence of anxiety and depression. METHODS: Pressure pain thresholds (PPTs) were assessed bilaterally from 9 points distributed over the temporalis muscle (3 points in the anterior portion, 3 in the middle portion, and the remaining 3 in the posterior portion of the muscle belly) in 113 patients with FETTH and 91 with CTTH in a blinded design...
February 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28226376/hyaluronic-acid-fillers-in-soft-tissue-regeneration
#5
Arianna Fallacara, Stefano Manfredini, Elisa Durini, Silvia Vertuani
Over the last years, hyaluronic acid (HA) injectable dermal fillers (DFs) have become the most popular agents for soft tissue contouring and volumizing. HA fillers are characterized by most of the properties that an ideal DF should have, due to HA unique chemical-physical properties, biocompatibility, biodegradability, and versatility. Therefore, HA DFs have revolutionized the filler market with a high number of products, which differ in terms of HA source, cross-linkage (agent and degree), HA concentration, hardness, cohesivity, consistency, inclusion or lack of anesthetic, indication, and longevity of correction...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226262/an-urban-runoff-model-designed-to-inform-stormwater-management-decisions
#6
Nicole G Beck, Gary Conley, Lisa Kanner, Margaret Mathias
We present an urban runoff model designed for stormwater managers to quantify runoff reduction benefits of mitigation actions that has lower input data and user expertise requirements than most commonly used models. The stormwater tool to estimate load reductions (TELR) employs a semi-distributed approach, where landscape characteristics and process representation are spatially-lumped within urban catchments on the order of 100 acres (40 ha). Hydrologic computations use a set of metrics that describe a 30-year rainfall distribution, combined with well-tested algorithms for rainfall-runoff transformation and routing to generate average annual runoff estimates for each catchment...
February 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28225815/different-characteristics-of-mesenchymal-stem-cells-isolated-from-different-layers-of-full-term-placenta
#7
Yoo Shin Choi, Yong-Beom Park, Chul-Won Ha, Jin A Kim, Jin-Chul Heo, Woo-Jung Han, Soo-Young Oh, Suk-Joo Choi
BACKGROUND: The placenta is a very attractive source of mesenchymal stem cells (MSCs) for regenerative medicine due to readily availability, non-invasive acquisition, and avoidance of ethical issues. Isolating MSCs from parts of placenta tissue has obtained growing interest because they are assumed to exhibit different proliferation and differentiation potentials due to complex structures and functions of the placenta. The objective of this study was to isolate MSCs from different parts of the placenta and compare their characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28225774/environmental-characteristics-drive-variation-in-amazonian-understorey-bird-assemblages
#8
Juliana Menger, William E Magnusson, Marti J Anderson, Martin Schlegel, Guy Pe'er, Klaus Henle
Tropical bird assemblages display patterns of high alpha and beta diversity and, as tropical birds exhibit strong habitat specificity, their spatial distributions are generally assumed to be driven primarily by environmental heterogeneity and interspecific interactions. However, spatial distributions of some Amazonian forest birds are also often restricted by large rivers and other large-scale topographic features, suggesting that dispersal limitation may also play a role in driving species' turnover. In this study, we evaluated the effects of environmental characteristics, topographic and spatial variables on variation in local assemblage structure and diversity of birds in an old-growth forest in central Amazonia...
2017: PloS One
https://www.readbyqxmd.com/read/28225681/case-6-2017-a-57-year-old-woman-with-fatigue-sweats-weight-loss-headache-and-skin-lesions
#9
Paul A Monach, John H Stone, Amita Sharma, Rosalynn M Nazarian
Presentation of Case. Dr. Kevin J. Heaton (Medicine): A 57-year-old woman was seen in the outpatient rheumatology clinic of this hospital because of fatigue, night sweats, weight loss, headache, diffuse abdominal pain, and skin lesions. The patient had been well until approximately 24 months before..
February 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28225674/inhibiting-plasma-kallikrein-for-hereditary-angioedema-prophylaxis
#10
Aleena Banerji, Paula Busse, Mustafa Shennak, William Lumry, Mark Davis-Lorton, Henry J Wedner, Joshua Jacobs, James Baker, Jonathan A Bernstein, Richard Lockey, H Henry Li, Timothy Craig, Marco Cicardi, Marc Riedl, Ahmad Al-Ghazawi, Carolyn Soo, Ryan Iarrobino, Daniel J Sexton, Christopher TenHoor, Jon A Kenniston, Ryan Faucette, J Gordon Still, Harvey Kushner, Robert Mensah, Chris Stevens, Joseph C Biedenkapp, Yung Chyung, Burt Adelman
Background Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular-weight kininogen. Lanadelumab (DX-2930) is a new kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency. Methods We conducted a phase 1b, multicenter, double-blind, placebo-controlled, multiple-ascending-dose trial...
23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28225569/hepatic-alanine-differentiates-nonalcoholic-steatohepatitis-from-simple-steatosis-in-humans-and-mice-a-proton-mr-spectroscopy-study-with-long-echo-time
#11
Tae-Hoon Kim, Hong Young Jun, Ki-Jong Kim, Young Hwan Lee, Myeung Su Lee, Keum Ha Choi, Ki Jung Yun, Yong Yeon Jeong, Chung Hwan Jun, Eun Young Cho, Kwon-Ha Yoon
PURPOSE: To evaluate the hepatic metabolic alterations in nonalcoholic fatty liver disease (NAFLD) by using (1) H-MRS (proton magnetic resonance spectroscopy) with long echo time and to test the reproducibility of human study in an animal model. Liver biopsy is the gold standard for diagnosing NAFLD but with practical constraints. (1) H-MRS allows in vivo assessment of hepatocellular metabolism and has shown potential for biochemical differentiation in diffuse liver disease. MATERIALS AND METHODS: In all, 32 subjects (11 patients with nonalcoholic steatohepatitis [NASH], 15 with simple steatosis [SS], and six healthy controls) were studied...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225190/ahs-members-choice-award-for-the-best-headache-article
#12
Thomas N Ward
No abstract text is available yet for this article.
March 2017: Headache
https://www.readbyqxmd.com/read/28225189/new-headache-associate-editors
#13
Jason Roberts
No abstract text is available yet for this article.
March 2017: Headache
https://www.readbyqxmd.com/read/28225088/the-general-pts-component-hpr-determines-the-preference-for-glucose-over-mannitol
#14
Mangyu Choe, Young-Ha Park, Chang-Ro Lee, Yeon-Ran Kim, Yeong-Jae Seok
Preferential sugar utilization is a widespread phenomenon in biological systems. Glucose is usually the most preferred carbon source in various organisms, especially in bacteria where it is taken up via the phosphoenolpyruvate:sugar phosphotransferase system (PTS). The currently proposed model for glucose preference over non-PTS sugars in enteric bacteria including E. coli is strictly dependent on the phosphorylation state of the glucose-specific PTS component, enzyme IIA(Glc) (EIIA(Glc)). However, the mechanism of the preference among PTS sugars is largely unknown in Gram-negative bacteria...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224964/-horton-disease-in-the-elderly-patient
#15
REVIEW
Abrar-Ahmad Zulfiqar, Audrey Fouqué, Xavier Sui Seng, Nadir Kadri, Jean Doucet
Horton disease is difficult to diagnose in the elderly, due to the non-specificity of clinical signs. When evoked in the case of recent headaches, laboratory tests must be carried out to look for signs of inflammation.
January 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28224789/ultra-sensitive-room-temperature-operable-gas-sensors-using-p-type-na-zno-nanoflowers-for-diabetes-detection
#16
Rawat Jaisutti, Minkyung Lee, Jaeyoung Kim, Seungbeom Choi, Tae-Jun Ha, Jaekyun Kim, Hyoungsub Kim, Sung Kyu Park, Yong-Hoon Kim
Ultra-sensitive room-temperature operable gas sensors utilizing the photocatalytic activity of Na-doped p-type ZnO (Na:ZnO) nanoflowers (NFs) are demonstrated as a promising candidate for diabetes detection. The flowerlike Na:ZnO nano-particles possessing ultrathin hierarchical nanosheets were synthesized by a facile solution route at a low process temperature of 40 (o)C. It was found that the Na element acting as a p-type dopant was successfully incorporated in the ZnO lattice. Based on the synthesized p-type Na:ZnO NFs, room-temperature operable chemiresistive-type gas sensors were realized, activated by ultraviolet (UV) illumination...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28224786/cisplatin-crosslinked-multifunctional-nanodrugplexes-for-combination-therapy
#17
Weiqi Zhang, Ching-Hsuan Tung
Combination therapy efficiently tackles cancer by hitting multiple action mechanisms. However, drugs administered, simultaneously or sequentially, may not reach the targeted sites with the desired dose and ratio. The outcomes of combination therapy could be improved with a polymeric nanoparticle, which can simultaneously transport an optimal combination of drugs. We have demonstrated a simple one-pot strategy to formulate nanomedicines based on platinum coordination and the non-covalent interactions of the drugs...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28224326/treatment-with-telmisartan-a-long-acting-angiotensin-ii-receptor-blocker-prevents-migraine-attacks-in-japanese-non-responders-to-lomerizine
#18
Ken Ikeda, Sayori Hanashiro, Yuichi Ishikawa, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Ken Miura, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Yasuo Iwasaki
Lomerizine, calcium channel blocker, is the most used medication for migraine prophylaxis in Japan. The effectiveness of this drug is reported as 50-75%. Telmisartan is angiotensin II receptor blockers which plasma half-life is 24 h. We examined whether telmisartan has preventative benefits in lomerizine non-responsive migraineurs. Lomerizine non-responders received telmisartan (20 mg/day) for 3 months after the investigation period of 3 months. Blood pressure, frequency of headache days/month, headache severity, and doses of triptans and analgesics were analyzed by Wilcoxon signed rank test...
February 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28224300/nilotinib-first-line-therapy-in-patients-with-philadelphia-chromosome-negative-bcr-abl-positive-chronic-myeloid-leukemia-in-chronic-phase-enest1st-sub-analysis
#19
Andreas Hochhaus, Franҫois-Xavier Mahon, Philipp le Coutre, Ljubomir Petrov, Jeroen J W M Janssen, Nicholas C P Cross, Delphine Rea, Fausto Castagnetti, Andrzej Hellmann, Gianantonio Rosti, Norbert Gattermann, Maria Liz Paciello Coronel, Maria Asuncion Echeveste Gutierrez, Valentin Garcia-Gutierrez, Beatrice Vincenzi, Luca Dezzani, Francis J Giles
PURPOSE: The ENEST1st sub-analysis presents data based on Philadelphia chromosome (Ph) status, i.e., Ph+ and Ph-/BCR-ABL1 + chronic myeloid leukemia. METHODS: Patients received nilotinib 300 mg twice daily, up to 24 months. RESULTS: At screening, 983 patients were identified as Ph+ and 30 patients as Ph-/BCR-ABL + based on cytogenetic and RT-PCR assessment; 76 patients had unknown karyotype (excluded from this sub-analysis). In the Ph-/BCR-ABL1 + subgroup, no additional chromosomal aberrations were reported...
February 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28224114/ha-triggers-the-switch-from-mek1-sumoylation-to-phosphorylation-of-the-erk-pathway-in-influenza-a-virus-infected-cells-and-facilitates-its-infection
#20
Chengmin Wang, Huimin Liu, Jing Luo, Lin Chen, Meng Li, Wen Su, Na Zhao, Shelan Liu, Li Xie, Yaxiong Jia, Hua Ding, Xiufeng Wan, Hongxuan He
Several post-translational modifications in host cells are hijacked by pathogens to facilitate their propagation. A number of components of the influenza virus have been reported to be modified by small ubiquitin-like modifier (SUMO) proteins during infection. We hypothesized that the MAPK/ERK pathway could be modified by SUMO1 because the SUMOylation of MEK1 was quickly eliminated after influenza A virus infection. We identified host cell MEK1 as a target of SUMO1 through LC/MS/MS, and enhanced MEK1 SUMOylation inhibited the infection of the virus, while inhibition of host cell MEK1 SUMOylation facilitated virus propagation...
2017: Frontiers in Cellular and Infection Microbiology
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