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https://www.readbyqxmd.com/read/28454399/inhibition-of-lung-cancer-growth-by-hangamdan-b-is-mediated-by-macrophage-activation-to-m1-subtype
#1
Hye-Rin Park, Eun-Ji Lee, Seong-Cheol Moon, Tae-Wook Chung, Keuk-Jun Kim, Hwa-Seung Yoo, Chong-Kwan Cho, Ki-Tae Ha
Re-education of tumor-associated macrophages (TAMs) toward antitumor effectors may be a promising therapeutic strategy for the successful treatment of cancer. HangAmDan-B (HAD-B), a herbal formula, has been used for stimulating immune function and activation of vital energy to cancer patients in traditional Korean Medicine. Previous studies have reported the anti-angiogenic and anti-metastatic effects of HAD-B; however, evidence on the immunomodulatory action of HAD-B was not demonstrated. In the present study, immunocompetent mice were used to demonstrate the suppression of the in vivo growth of allograft Lewis lung carcinoma (LLC) cells, by HAD-B...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454367/matrix-metalloproteinases-in-vietnamese-patients-with-colorectal-cancer
#2
Thao Phuong Bui, Anh Ngoc Hoang, Phuong Lan Le, Bich Thi Pham, Linh Thi Tu Nguyen, Ha Minh Do, To Van Ta, Thai Hong Trinh
Matrix metalloproteinases (MMPs), a family of endopeptidases also known as gelatinases, have been reported to affect the acquisition of the cell proliferative, cell invasive and metastatic phenotype of several types of cancer. In particular, the gelatinases MMP-2 and -9 have been revealed to facilitate tumor growth and invasion in patients with colorectal cancer (CRC). However, it is not known whether the gelatinase activity of MMP-2 and -9 is also elevated in Vietnamese patients with CRC. The activity of MMP-2 and -9 in the tissue samples of 103 patients with CRC was evaluated by gelatin zymography and quantified using ImageJ...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454348/effects-of-ptcs-on-nonsense-mediated-mrna-decay-are-dependent-on-ptc-location
#3
Heegyum Moon, Xuexiu Zheng, Tiing Jen Loh, Ha Na Jang, Yongchao Liu, Da-Woon Jung, Darren R Williams, Haihong Shen
The récepteur d'origine nantais (RON) gene is a proto-oncogene that is responsible for encoding the human macrophage-stimulating protein (MSP) 1 receptor. MSP activation induces RON-mediated cell dissociation, migration and matrix invasion. Isoforms of RON that exclude exons 5 and 6 encode the RONΔ160 protein, which promotes cell transformation in vitro and tumor metastasis in vivo. Premature termination codons (PTCs) in exons activate the nonsense-mediated mRNA decay (NMD) signaling pathway. The present study demonstrated that PTCs at various locations in the alternative exons 5 and 6 could induce NMD of the majority of the spliced, or partially spliced, isoforms...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454286/suspected-tumor-to-meningioma-metastasis-a-case-report
#4
Iuri Santana Neville, Davi Fontoura Solla, Arthur Maynart Oliveira, Cesar Casarolli, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Tumor-to-meningioma metastasis (TMM) is a fairly uncommon phenomenon. Only 7 cases of prostate cancer with TMM have previously been described in the literature. The present study aimed to report a case of prostate cancer TMM, and to discuss the relevant clinical and neuroimaging aspects of this condition. A 68-year-old patient presented with headaches, poor visual acuity in the left eye and ipsilateral eyelid droop 3 years after a Simpson II resection of a left sphenoid wing meningioma. Computed tomography revealed a hyperdense area suggestive of a recurrent left sphenoid wing meningioma...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454091/heterogeneous-nuclear-ribonucleoprotein-hnrnp-l-promotes-dna-damage-induced-cell-apoptosis-by-enhancing-the-translation-of-p53
#5
Ji-Young Seo, Do-Yeon Kim, Seong-Hoon Kim, Hyo-Jin Kim, Hye Guk Ryu, Juhyun Lee, Kyung-Ha Lee, Kyong-Tai Kim
The tumor suppressor p53 is an essential gene in the induction of cell cycle arrest, DNA repair, and apoptosis. p53 protein is induced under cellular stress, blocking cell cycle progression and inducing DNA repair. Under DNA damage conditions, it has been reported that post-transcriptional regulation of p53 mRNA contributes to the increase in p53 protein level. Here we demonstrate that heterogeneous nuclear ribonucleoprotein (hnRNP) L enhances p53 mRNA translation. We found that hnRNP L is increased and binds to the 5'UTR of p53 mRNA in response to DNA damage...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453951/are-biodegradable-plates-applicable-in-endoscope-assisted-open-reduction-and-internal-fixation-of-mandibular-subcondyle-fractures
#6
Jang-Ho Son, Jinhee Ha, Yeong-Cheol Cho, Iel-Yong Sung
PURPOSE: To investigate whether biodegradable plates are applicable in endoscope-assisted open reduction and internal fixation (EAORIF) of mandibular subcondyle fractures. MATERIALS AND METHODS: This retrospective case-series study included patients with mandibular subcondyle fractures treated with EAORIF using an unsintered hydroxyapatite particles/poly-l-lactide biodegradable plate system, with at least 6 months of clinical follow-up data available. The outcome variables were fracture healing with postoperative stability and postoperative complications...
April 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28453716/inflated-medicine-prices-in-vietnam-a-qualitative-study
#7
Tuan Anh Nguyen, Rosemary Knight, Andrea Mant, Husna Razee, Geoffrey Brooks, Thu Ha Dang, Elizabeth Ellen Roughead
One third of the world's population lacks regular access to essential medicines partly because of the high cost of medicines. In Vietnam, the cost to patients of medicines was 47 times the international reference price for originator brands and 11 times the price for generic equivalents in the public sector. In this article, we report the results of a qualitative study conducted to identify the principal reasons for inflated medicine prices in Vietnam.Between April 2008 and December 2009, 29 semi-structured interviews were conducted with staff from pharmaceutical companies, private pharmacies, the Ministry of Health, and the Ministry of Finance of Vietnam...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453445/the-effectiveness-of-a-cognitive-behavioral-exercise-approach-cbea-compared-to-usual-care-in-patients-with-a-whiplash-associated-disorder-a-quasi-experimental-clinical-trial
#8
Jorge Hugo Villafañe, Davide Perucchini, Joshua A Cleland, Cristina Barbieri, Fernanda de Lima E Sá Resende, Stefano Negrini
BACKGROUND: Whiplash Associated Disorders (WAD) is a biopsychosocial problem, education may be an essential part in the treatment and the prevention of chronic WAD. However, it is still unclear which type of educative intervention has already been used in WAD patients and how effective such interventions are. OBJECTIVE: To examine the effectiveness of a cognitive behavioral exercises approach (CBEA) for self-training of the neck relative to usual care in individuals with WAD in acute phase...
April 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28449463/efficacy-of-nebulized-colistin-based-therapy-without-concurrent-intravenous-colistin-for-ventilator-associated-pneumonia-caused-by-carbapenem-resistant-acinetobacter-baumannii
#9
Yong Kyun Kim, Jae Ha Lee, Hyun-Kyung Lee, Byung Cheol Chung, Seung Jung Yu, Ho-Young Lee, Jin-Han Park, Sunyoung Kim, Hyeon-Kuk Kim, Sungmin Kiem, Hang-Jea Jang
BACKGROUND: Although there have been studies regarding the role of nebulized colistin as adjunctive therapy of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB), a paucity of information on the efficacy of nebulized colistin as monotherapy is available. METHODS: We retrospectively reviewed 219 patients with VAP caused by CRAB treated with either intravenous (n=93) or nebulized colistin (n=126), from March 2010 to November 2015...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449254/bioresorbable-fe-mn-and-fe-mn-ha-materials-for-orthopedic-implantation-enhancing-degradation-through-porosity-control
#10
Michael Heiden, Eric Nauman, Lia Stanciu
Resorbable, porous iron-manganese-hydroxyapatite biocomposites with suitable degradation rates for orthopedic applications are prepared using salt-leaching for the first time. These transient biomaterials have the potential to replace inert, permanent implants that can suffer from long-term complications, or have to be surgically removed, leaving an unfavorable void. Fe30Mn-10HA materials are newly developed to address inadequate resorption rates of degradable materials proposed for orthopedic environments in the past...
April 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28448878/rapid-extraction-of-uranium-from-sea-water-using-fe3o4-and-humic-acid-coated-fe3o4-nanoparticles
#11
Pallavi Singhal, Sanjay K Jha, Shailaja P Pandey, Suman Neogy
Uranium is one of the most toxic elements present in the environment and a number of methods have been developed for its extraction. Herein we have demonstrated a new method using magnetic nanoparticles (NPs) that can be used for uranium extraction from water and sea water matrix. Fe3O4 and humic acid (HA) coated Fe3O4 NPs with different amount of HA coating were synthesized and uranium sorption from water and sea water matrix was demonstrated. It was observed that sorption increases with increase in amount of HA coating...
April 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28448844/consequences-of-bioenergy-wood-extraction-for-landscape-level-availability-of-habitat-for-dead-wood-dependent-organisms
#12
Matthew Hiron, Mats Jonsell, Ariana Kubart, Göran Thor, Martin Schroeder, Anders Dahlberg, Victor Johansson, Thomas Ranius
Stumps and slash resulting from forest clearcutting is used as a source of low-net-carbon energy, but there are concerns about the consequences of biofuel extraction on biodiversity. Logging residues constitute potentially important habitats, since a large part of forest biodiversity is dependent on dead wood. Here we used snapshot field data from a managed forest landscape (25 000 ha) to predict landscape scale population changes of dead wood dependent organisms after extraction of stumps and slash after clearcutting...
April 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28448748/evaluation-of-humic-substances-removal-from-leachates-originating-from-solid-waste-landfills-in-rio-de-janeiro-state-brazil
#13
Letícia S M S Lima, Ronei De Almeida, Bianca R Quintaes, Daniele M Bila, Juacyara C Campos
This study aimed to evaluate the use of coagulation/flocculation and Fenton processes for the removal of the recalcitrant component, in particular humic substances, from two different leachates generated in the Gericinó and Gramacho landfills in Rio de Janeiro State (Brazil). A coagulation/flocculation process, using FeCl3·6H2O as the coagulant, was applied to the two leachate samples. In the case of the leachate from Gericinó landfill, the treatment removed 93% of color, 71% of TOC, 69% of COD, 76% of HS, 73% of humic acids (HA) and 82% of fulvic acids (FA)...
April 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28448607/complementing-the-topsoil-information-of-the-land-use-land-cover-area-frame-survey-lucas-with-modelled-n2o-emissions
#14
Emanuele Lugato, Lily Paniagua, Arwyn Jones, Wim de Vries, Adrian Leip
Two objectives of the Common Agricultural Policy post-2013 (CAP, 2014-2020) in the European Union (EU) are the sustainable management of natural resources and climate smart agriculture. To understand the CAP impact on these priorities, the Land Use/Cover statistical Area frame Survey (LUCAS) employs direct field observations and soil sub-sampling across the EU. While a huge amount of information can be retrieved from LUCAS points for monitoring the environmental status of agroecosystems and assessing soil carbon sequestration, a fundamental aspect relating to climate change action is missing, namely nitrous oxide (N2O) soil emissions...
2017: PloS One
https://www.readbyqxmd.com/read/28448425/vulnerability-to-psychopathology-and-dimensions-of-personality-in-patients-with-fibromyalgia
#15
Alba Garcia-Fontanals, Mariona Portell, Susanna García-Blanco, Violant Poca-Dias, Ferran García-Fructuoso, Marina López-Ruiz, Teresa Gutiérrez-Rosado, Montserrat Gomà-I-Freixanet, Joan Deus
OBJECTIVE: Fibromyalgia (FM) patients may present psychopathology and some characteristic personality traits that may affect their adaptation to the disease. This paper aims to study the relationship between personality dimensions according to the psychobiological model of Cloninger and the presence of psychopathology. METHOD: The study sample consisted of 42 patients with FM and 38 healthy controls. The assessment instruments administered were the Temperament and Character Inventory (TCI-R) and the Millon Clinical Multiaxial Inventory (MCMI-III)...
April 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28448166/changes-in-motorcycle-related-injuries-and-deaths-after-mandatory-motorcycle-helmet-law-in-a-district-of-vietnam
#16
Ninh Thi Ha, David Ederer, Van Anh Vo Ha, An Van Pham, Anthony Mounts, Leisha Nolen, David Sugerman
OBJECTIVE: Our study measured the change in head injuries and deaths among motorcycle users in Cu Chi district, a suburban district of Ho Chi Minh City. METHODS: Hospital records for road traffic injuries (RTI) were collected from the Cu Chi Trauma Centre and motorcycle-related death records were obtained from mortality registries in commune health offices. Head injury severity was categorised using the Abbreviated Injury Score (AIS). Rate ratios (RR) were used to compare rates pre- and post-law (2005/06-2009/10)...
April 27, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28447489/forodesine-in-the-treatment-of-cutaneous-t-cell-lymphoma
#17
Daniel J Lewis, Madeleine Duvic
Cutaneous T-cell lymphoma (CTCL) is characterized by the accumulation of neoplastic CD4+ T lymphocytes in the skin. Given the lack of curative treatments for CTCL, there is a significant need for new, superior therapies. Forodesine is a transition-state analogue that inhibits purine nucleoside phosphorylase. Because it selectively targets T lymphocytes, it represents a drug of interest for the treatment of CTCL. Areas covered: Phase I/II dose-ranging studies of intravenous (IV) and oral forodesine demonstrated its activity, safety, and tolerability for refractory CTCL...
April 27, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28447450/band-bending-of-ga-polar-gan-interfaced-with-al2o3-through-ultraviolet-ozone-treatment
#18
Kwangeun Kim, Jae Ha Ryu, Jisoo Kim, Sang June Cho, Dong Liu, Jeongpil Park, In-Kyu Lee, Baxter Moody, Weidong Zhou, John Albrecht, Zhenqiang Ma
Understanding the band bending at the interface of GaN/dielectric under different surface treatment conditions is critically important for device design, device performance, and device reliability. The effects of ultraviolet/ozone (UV/O3) treatment of the GaN surface on the energy band bending of atomic-layer-deposition (ALD) Al2O3 coated Ga-polar GaN were studied. The UV/O3 treatment and post-ALD anneal can be used to effectively vary the band bending, valence band offset, conduction band offset, and interface dipole at the Al2O3/GaN interfaces...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28447370/vulnerability-to-forest-loss-through-altered-postfire-recovery-dynamics-in-a-warming-climate-in-the-klamath-mountains
#19
Alan J Tepley, Jonathan R Thompson, Howard E Epstein, Kristina J Anderson-Teixeira
In the context of ongoing climatic warming, certain landscapes could be near a tipping point where relatively small changes to their fire regimes or their postfire forest recovery dynamics could bring about extensive forest loss, with associated effects on biodiversity and carbon-cycle feedbacks to climate change. Such concerns are particularly valid in the Klamath Region of northern California and southwestern Oregon, where severe fire initially converts montane conifer forests to systems dominated by broadleaf trees and shrubs...
April 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28447301/management-of-chemotherapy-induced-nausea-and-vomiting-in-pediatric-patients
#20
REVIEW
Rudolph M Navari
Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is perceived by patients as a major adverse effect of the treatment. This review summarizes the safety and efficacy of current antiemetic agents for the prevention of CINV in children. Information on antiemetic prophylaxis for CINV in children was obtained from a literature review of current peer-reviewed articles and recent international guidelines. The literature review and the international antiemetic guidelines provide recommendations for use of specific antiemetics in children based on the emetogenicity of the chemotherapy...
April 21, 2017: Paediatric Drugs
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