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https://www.readbyqxmd.com/read/28545130/responses-of-absolute-and-specific-enzyme-activity-to-consecutive-application-of-composted-sewage-sludge-in-a-fluventic-ustochrept
#1
Xiao Liu, Kangli Guo, Lin Huang, Zhengyu Ji, Huimin Jiang, Hu Li, Jianfeng Zhang
Composted sewage sludge (CS) is considered a rich source of soil nutrients and significantly affects the physical, chemical, and biological characteristics of soil, but its effect on specific enzyme activity in soil is disregarded. The present experiment examined the absolute and specific enzyme activity of the enzymes involved in carbon, nitrogen, and phosphorus cycles, the diversity of soil microbial functions, and soil community composition in a Fluventic Ustochrept under a maize-wheat rotation system in North China during 2012-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28545112/home-range-size-of-tengmalm-s-owl-during-breeding-in-central-europe-is-determined-by-prey-abundance
#2
Marek Kouba, Luděk Bartoš, Václav Tomášek, Alena Popelková, Karel Šťastný, Markéta Zárybnická
Animal home ranges typically characterized by their size, shape and a given time interval can be affected by many different biotic and abiotic factors. However, despite the fact that many studies have addressed home ranges, our knowledge of the factors influencing the size of area occupied by different animals is, in many cases, still quite poor, especially among raptors. Using radio-telemetry (VHF; 2.1 g tail-mounted tags) we studied movements of 20 Tengmalm's owl (Aegolius funereus) males during the breeding season in a mountain area of Central Europe (the Czech Republic, the Ore Mountains: 50° 40' N, 13° 35' E) between years 2006-2010, determined their average hunting home range size and explored what factors affected the size of home range utilised...
2017: PloS One
https://www.readbyqxmd.com/read/28544985/experiences-of-nursing-students-and-educators-during-the-co-construction-of-clinical-nursing-leadership-learning-activities-a-qualitative-research-and-development-study
#3
Laurence Ha, Jacinthe Pepin
BACKGROUND: Student voice posits that students' unique perspectives on teaching and learning can be used in conjunction with those of educators to create meaningful educational activities. OBJECTIVE: The study aimed to describe nursing students' and educators' experiences during the co-construction of educational activities involving clinical nursing leadership. DESIGN: Qualitative research and development model. SETTING: The study was conducted at a French-Canadian nursing faculty that provides a 3-year undergraduate program...
May 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28544350/association-between-the-zinc-finger-protein-804a-znf804a-gene-and-the-risk-of-schizophrenia-and-bipolar-i-disorder-across-diagnostic-boundaries
#4
Ji Hyun Baek, Kyooseob Ha, Yongkang Kim, So Yung Yang, Eun-Young Cho, Yujin Choi, Seunghyong Ryu, Yu-Sang Lee, Taesung Park, Kyung Sue Hong
OBJECTIVES: In this study, we aimed to determine the role of genetic variations within the zinc finger protein 804A (ZNF804A) gene, a candidate for a psychosis risk-conferring gene, in the development of schizophrenia (SZ) and bipolar disorder (BP) in the Korean population. METHODS: A total of 921 patients with SZ, bipolar I (BP-I) and II (BP-II) disorder, and 502 control subjects participated in the study. Twenty-one tag single nucleotide polymorphisms (SNPs) across the genomic region of ZNF804A and seven reference SNPs based on previous reports were genotyped...
May 22, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28544341/synthesized-enone-fatty-acids-resembling-metabolites-from-gut-microbiota-suppress-macrophage-mediated-inflammation-in-adipocytes
#5
Ha-Eun Yang, Yongjia Li, Akira Nishimura, Huei-Fen Jheng, Ana Yuliana, Ryuji Kitano-Ohue, Wataru Nomura, Nobuyuki Takahashi, Chu-Sook Kim, Rina Yu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Teruo Kawada, Tsuyoshi Goto
SCOPE: Recent reports indicate that gut microbiota and their metabolite may regulate inflammatory conditions, including the chronic inflammation of obese adipose tissues, in the host. In this study, we investigated whether specific synthesized fatty acids, identical to the metabolites generated by gut microbiota, act as anti-inflammatory factors in inflammation-induced obesity. METHODS AND RESULTS: We first used lipopolysaccharide-stimulated RAW 264.7 macrophages to examine the anti-inflammatory effect of fatty acids synthesized to resemble representative polyunsaturated fatty acid metabolites from gut microbiota...
May 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28544265/lasting-improvement-of-medication-overuse-headache-after-brief-intervention-a-long-term-follow-up-in-primary-care
#6
E S Kristoffersen, J Straand, M B Russell, C Lundqvist
BACKGROUND AND PURPOSE: Withdrawal therapy improves the headache situation for many patients with medication-overuse headache (MOH), but relapses are common. The objective was to assess the long-term effectiveness of a general practitioner conducted brief intervention (BI) for MOH. METHODS: Sixty MOH patients initially participating in a blinded cluster-randomized controlled trial evaluating BI versus business as usual (BAU) were followed up for 16 months. Follow-up was open after 6 months...
May 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28544252/soil-organic-carbon-dynamics-jointly-controlled-by-climate-carbon-inputs-soil-properties-and-soil-carbon-fractions
#7
Zhongkui Luo, Wenting Feng, Yiqi Luo, Jeff Baldock, Enli Wang
Soil organic carbon (SOC) dynamics are regulated by the complex interplay of climatic, edaphic and biotic conditions. However, the interrelation of SOC and these drivers and their potential connection networks are rarely assessed quantitatively. Using observations of SOC dynamics with detailed soil properties from 90 field trials at 28 sites under different agroecosystems across the Australian cropping regions, we investigated the direct and indirect effects of climate, soil properties, carbon (C) inputs and soil C pools (a total of 17 variables) on SOC change rate (rC , Mg C ha(-1) yr(-1) )...
May 19, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28544039/cofactor-free-direct-photoactivation-of-enoate-reductases-for-asymmetric-reduction-of-c-c-bonds
#8
Sahng Ha Lee, Da Som Choi, Milja Pesic, Yang Woo, Caroline Paul, Frank Hollmann, Chan Beum Park
Enoate reductases from the family of Old Yellow Enzymes (OYEs) can catalyze stereoselective trans-hydrogenation of activated C=C bonds. Here, we report visible light-driven activation of OYEs through NAD(P)H-free, direct transfer of photoexcited electrons from xanthene dyes to the prosthetic flavin moiety. Our spectroscopic and electrochemical analyses verified spontaneous association of rose bengal and its derivatives with OYEs. Illumination of a white light-emitting-diode triggered photoreduction of OYEs by xanthene dyes, which facilitated the enantioselective reduction of C=C bonds in the absence of NADH...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543874/ex-vivo-magnetic-resonance-imaging-using-hyaluronic-acid-fillers-differences-between-monophasic-and-biphasic-fillers
#9
M J Kim, W-J Moon, M S Hur, S H Han, Y W Lee, Y B Choe, K J Ahn
BACKGROUND/PURPOSE: Hyaluronic acid (HA) is an anionic, non-sulfated glycosaminoglycan distributed throughout the human skin and injectable HA fillers are the most commonly used in aesthetic field. This study aimed to determine if differences in physical characteristics of HA products (monophasic or biphasic fillers) affect the patterns of magnetic resonance imaging (MRI). METHODS: Twenty biphasic fillers and nine monophasic fillers were obtained from a commercial source, and examined with a 3...
May 25, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28543053/sofosbuvir-and-ribavirin-in-adolescents-12-to-17-years-old-with-hepatitis-c-virus-genotype-2-or-3-infection
#10
Stefan Wirth, Philip Rosenthal, Regino P Gonzalez-Peralta, Maureen M Jonas, William F Balistreri, Lin Chuan-Hao, Winita Hardikar, Kathryn Kersey, Benedetta Massetto, Bittoo Kanwar, Diana M Brainard, Jiang Shao, Evguenia Svarovskaia, Brian Kirby, Ronen Arnon, Karen F Murray, Kathleen B Schwarz
BACKGROUND & AIMS: Children with chronic hepatitis C virus (HCV) infection have limited treatment options. We evaluated the all-oral combination of sofosbuvir and ribavirin in adolescents aged 12-17 with HCV genotype 2 or 3. METHODS: Fifty-two patients received sofosbuvir 400mg once daily and weight-based ribavirin twice daily for 12 (genotype 2) or 24 (genotype 3) weeks. The pharmacokinetics of sofosbuvir and its metabolite GS-331007 were evaluated by intensive plasma sampling at day 7 in the first 10 patients enrolled, and by sparse sampling in all patients throughout treatment...
May 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28542914/efficacy-and-adverse-events-of-oral-isotretinoin-for-acne-a-systematic-review
#11
REVIEW
I A Vallerand, R T Lewinson, M S Farris, C D Sibley, M L Ramien, A G M Bulloch, S B Patten
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total n=760 patients randomized), containing mostly males. Mean treatment ages ranged from 18 to 47.9 years and participants generally had moderate-severe acne...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28542913/reduction-of-escherichia-coli-o157-h7-in-biofilms-using-bacteriophage-bpeco-19
#12
Mohammad Sadekuzzaman, Sungdae Yang, Md Furkanur Rahaman Mizan, Sang-Do Ha
Biofilm formation is a growing concern in the food industry. Escherichia coli O157:H7 is one of the most important foodborne pathogens that can persists in food and food-related environments and subsequently produce biofilms. The efficacy of bacteriophage BPECO 19 was evaluated against three E. coli O157:H7 strains in biofilms. Biofilms of the three E. coli O157:H7 strains were grown on abiotic (stainless steel, rubber, and minimum biofilm eradication concentration [MBEC(TM) ] device) and biotic (lettuce) surfaces at different temperatures...
May 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28542895/aura-and-other-neurologic-dysfunction-in-or-with-migraine
#13
Narayan R Kissoon, Fred Michael Cutrer
PREMISE: Migraine can present with a wide range of neurological symptoms. PROBLEM: Based on currently available data, the symptoms of typical migraine aura are most likely related to cortical spreading depression (CSD), and evidence supports that CSD can lead to trigeminovascular activation resulting in the headache phase of migraine. POTENTIAL SOLUTION: An alternative diagnosis to migraine aura should be considered if migrainous headaches present with transient neurological symptoms that have features inconsistent with aura...
May 19, 2017: Headache
https://www.readbyqxmd.com/read/28542727/tics-in-tacs-a-step-into-an-avalanche-systematic-literature-review-and-conclusions
#14
Christian Wöber
BACKGROUND: Trigeminal autonomic cephalalgias (TACs) comprise cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks, and hemicrania continua. In some cases, trigeminal neuralgia (TN, "tic douloureux") or TN-like pain may co-occur with TACs. AIM: This article will review the co-occurrence and overlap of TACs and tics in order to contribute to a better understanding of the issue and an improved management of the patients. METHODS: For performing a systematic literature review Pubmed was searched using a total of ten terms...
May 19, 2017: Headache
https://www.readbyqxmd.com/read/28542715/hyperleucocytosis-in-paediatric-acute-myeloid-leukaemia-the-challenge-of-white-blood-cell-counts-above-200%C3%A2-%C3%A3-%C3%A2-10-9-l-the-nopho-experience-1984-2014
#15
Bernward Zeller, Heidi Glosli, Erik Forestier, Shau-Yin Ha, Kirsi Jahnukainen, Ólafur G Jónsson, Birgitte Lausen, Josefine Palle, Henrik Hasle, Jonas Abrahamsson
Hyperleucocytosis in paediatric acute myeloid leukaemia (AML) is associated with increased morbidity and mortality. We studied hyperleucocytosis in 890 patients with AML aged 0-18 years registered in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) registry, with special focus on very high white blood cell counts (WBC >200 × 10/l). Eighty-six patients (10%) had WBC 100-199 × 10(9) /l and 57 (6%) had WBC ≥200 × 10(9) /l. Patients with WBC ≥200 × 10(9) /l had a high frequency of t(9;11) and a paucity of trisomy 8...
May 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542649/evaluation-of-connectivity-map-discovered-celastrol-as-a-radiosensitizing-agent-in-a-murine-lung-carcinoma-model-feasibility-study-of-diffusion-weighted-magnetic-resonance-imaging
#16
Hong Young Jun, Tae-Hoon Kim, Jin Woo Choi, Young Hwan Lee, Kang Kyoo Lee, Kwon-Ha Yoon
This study was designed to identify potential radiosensitizing (RS) agents for combined radio- and chemotherapy in a murine model of human lung carcinoma, and to evaluate the in vivo effect of the RS agents using diffusion-weighted magnetic resonance imaging (DW-MRI). Radioresistance-associated genes in A549 and H460 cells were isolated on the basis of their gene expression profiles. Celastrol was selected as a candidate RS by using connectivity mapping, and its efficacy in lung cancer radiotherapy was tested...
2017: PloS One
https://www.readbyqxmd.com/read/28542410/gla-rich-protein-function-as-an-anti-inflammatory-agent-in-monocytes-macrophages-implications-for-calcification-related-chronic-inflammatory-diseases
#17
Carla S B Viegas, Rúben M Costa, Lúcia Santos, Paula A Videira, Zélia Silva, Nuna Araújo, Anjos L Macedo, António P Matos, Cees Vermeer, Dina C Simes
Calcification-related chronic inflammatory diseases are multifactorial pathological processes, involving a complex interplay between inflammation and calcification events in a positive feed-back loop driving disease progression. Gla-rich protein (GRP) is a vitamin K dependent protein (VKDP) shown to function as a calcification inhibitor in cardiovascular and articular tissues, and proposed as an anti-inflammatory agent in chondrocytes and synoviocytes, acting as a new crosstalk factor between these two interconnected events in osteoarthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28542287/the-relationship-between-occupational-noise-and-vibration-exposure-and-headache-eyestrain-based-on-the-fourth-korean-working-condition-survey-kwcs
#18
Jihyun Kim, Wanhyung Lee, Jong-Uk Won, Jin-Ha Yoon, Hongdeok Seok, Yeong-Kwang Kim, Seunghyun Lee, Jaehoon Roh
INTRODUCTION: The individual and combined effect of occupational noise and vibration exposures, on workers' health has not been thoroughly investigated. In order to find better ways to prevent and manage workers' headache, this study aimed to investigate the effects of occupational noise and vibration exposure on headache/eyestrain. METHODS: We used data from the fourth Korean Working Condition Survey (2014). After applying inclusion and exclusion criteria, 25,751 workers were included...
2017: PloS One
https://www.readbyqxmd.com/read/28542275/combination-of-the-immunization-with-the-sequence-close-to-the-consensus-sequence-and-two-dna-prime-plus-one-vlp-boost-generate-h5-hemagglutinin-specific-broad-neutralizing-antibodies
#19
Guiqin Wang, Renfu Yin, Paul Zhou, Zhuang Ding
Hemagglutinin (HA) head has long been considered to be able to elicit only a narrow, strain-specific antibody response as it undergoes rapid antigenic drift. However, we previously showed that a heterologous prime-boost strategy, in which mice were primed twice with DNA encoding HA and boosted once with virus-like particles (VLP) from an H5N1 strain A/Thailand/1(KAN)-1/2004 (noted as TH DDV), induced anti-head broad cross-H5 neutralizing antibody response. To explain why TH DDV immunization could generate such breadth, we systemically compared the neutralization breadth and potency between TH DDV sera and immune sera elicited by TH DDD (three times of DNA immunizations), TH VVV (three times of VLP immunizations), TH DV (one DNA prime plus one VLP boost) and TK DDV (plasmid DNA and VLP derived from another H5N1 strain, A/Turkey/65596/2006)...
2017: PloS One
https://www.readbyqxmd.com/read/28542228/alteration-of-membrane-complement-regulators-is-associated-with-transporter-status-in-patients-on-peritoneal-dialysis
#20
Daniel Kitterer, Dagmar Biegger, Stephan Segerer, Niko Braun, M Dominik Alscher, Joerg Latus
INTRODUCTION: A growing body of evidence from animal models and cell culture studies indicate an important role of a local regulatory complement system (CS) in peritoneal injury during peritoneal dialysis (PD). We investigated the expression of the local regulatory CS (reflected by CD46,CD55,CD59) in the peritoneal tissue of patients with different membrane function characteristics. PATIENTS AND METHODS: Biopsies from the parietal peritoneum were taken from 24 patients on PD, 22 uremic patients prior to PD...
2017: PloS One
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