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https://www.readbyqxmd.com/read/28078976/beyond-purity
#1
Roger Giner-Sorolla, Hanah A Chapman
Previous studies support a link between moral disgust and impurity, whereas anger is linked to harm. We challenged these strict correspondences by showing that disgust is activated in response to information about moral character, even for harm violations. By contrast, anger is activated in response to information about actions, including their moral wrongness and consequences. Study 1 examined disgust and anger in response to an action that suggests bad moral character (animal cruelty) versus an action that is seen as inherently more wrong (domestic abuse)...
January 2017: Psychological Science
https://www.readbyqxmd.com/read/28076529/relationships-between-oncohematopediatrics-mothers-and-children-in-communicating-bad-news
#2
Selene Beviláqua Chaves Afonso, Maria Cecília de Souza Minayo
We present a study about the relations between pediatric oncological haematologists, mothers, and children in sharing bad news (BN) in a public hospital in Rio de Janeiro. The text emphasizes the intertwining of technique and emotions for the treatment of children with diagnoses in which the fatal outcome is always a probability. We used a qualitative approach, privileging participant observation and open interviews with oncologists (at this service all professionals were female) and mothers. We sought to understand the importance of communication which includes expressions and control of emotions; bioethical issues that require sensitivity, serenity, and truth about approaching the end of life; and how the professionals balance proximity to children and families and objectivity in their activity...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076372/bad-to-the-bone-on-in-vitro-and-ex-vivo-microbial-biofilm-ability-to-directly-destroy-colonized-bone-surfaces-without-participation-of-host-immunity-or-osteoclastogenesis
#3
Adam Junka, Patrycja Szymczyk, Grzegorz Ziółkowski, Ewa Karuga-Kuzniewska, Danuta Smutnicka, Iwona Bil-Lula, Marzenna Bartoszewicz, Susan Mahabady, Parish Paymon Sedghizadeh
Bone infections are a significant public health burden associated with morbidity and mortality in patients. Microbial biofilm pathogens are the causative agents in chronic osteomyelitis. Research on the pathogenesis of osteomyelitis has focused on indirect bone destruction by host immune cells and cytokines secondary to microbial insult. Direct bone resorption by biofilm pathogens has not yet been seriously considered. In this study, common osteomyelitis pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Streptococcus mutans) were grown as biofilms in multiple in vitro and ex vivo experiments to analyze quantitative and qualitative aspects of bone destruction during infection...
2017: PloS One
https://www.readbyqxmd.com/read/28074313/characterizing-clinical-genetic-counselors-countertransference-experiences-an-exploratory-study
#4
Rebecca Reeder, Patricia McCarthy Veach, Ian M MacFarlane, Bonnie S LeRoy
Countertransference (CT) refers to conscious and unconscious emotions, fantasies, behaviors, perceptions, and psychological defenses genetic counselors experience in response to any aspect of genetic counseling situations (Weil 2010). Some authors theorize about the importance of recognizing and managing CT, but no studies solely aim to explore genetic counselors' experiences of the phenomenon. This study examined the extent to which clinical genetic counselors' perceive themselves as inclined to experience CT, gathered examples of CT encountered in clinical situations, and assessed their CT management strategies...
January 10, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28073870/successful-treatment-of-takayasu-arteritis-with-rituximab-as-a-first-line-immunosuppressant
#5
Mortimer B O'Connor, Neil O'Donovan, Ursula Bond, Mark J Phelan
Takayasu arteritis is a rare large vessel vasculitis which has traditionally been treated with high-dose steroids. There have been a small number of publications where biological agents have been used to manage refractory cases. To the authors knowledge, there are no publications using biological agents in combination with steroids as a first-line treatment in Takayasu arteritis. In this publication, we document the case of Takayasu arteritis, in a 39-year-old woman, where rituximab was used in combination with steroids as a first-line agent in the setting of poorly controlled bipolar affective disorder...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28072478/the-difficulties-experienced-by-nurses-and-healthcare-staff-involved-in-the-process-of-breaking-bad-news
#6
Clare Warnock, Jean Buchanan, Angela Mary Tod
AIMS: To explore the difficulties experienced by nurses and healthcare professionals when engaging in the process of breaking bad news BACKGROUND: The challenges faced by staff when breaking bad news have previously been researched in relation to particular settings or subjects. This study involved staff from diverse settings and roles to develop broader insights into the range of difficulties experienced in clinical practice. DESIGN: The study used a descriptive survey design involving self-reported written accounts and framework analysis...
January 10, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28072037/benzodiazepine-maintenance-in-opiate-substitution-treatment-good-or-bad-a-retrospective-primary-care-case-note-review
#7
Adam Bakker, Emmanuel Streel
BACKGROUND: Co-prescribing benzodiazepines to patients in opiate substitution treatment is controversial and often alleged to increase mortality. In an inner-London general practice, patients with problematic benzodiazepine co-dependence were allowed benzodiazepine maintenance treatment (BMT) since 1994, providing an opportunity for analysis. METHOD: 1) Case-note review of all 278 opiate substitution treatment patients, accruing 1289 patient treatment years; 46% had concurrent BMT...
January 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28068874/short-lag-spatial-coherence-ultrasound-imaging-with-adaptive-synthetic-transmit-aperture-focusing
#8
Jinxin Zhao, Yuanyuan Wang, Jinhua Yu, Wei Guo, Shun Zhang, Saeid Aliabadi
The short-lag spatial coherence (SLSC) imaging has been demonstrated to be advantageous over the traditional B-mode ultrasound imaging. With focused scanning beams, the SLSC imaging has an excellent performance in clutter reduction and lesion detection, especially in the low signal-to-noise ratio (SNR) scenarios. The synthetic aperture (SA) imaging is an appropriate mode for the SLSC imaging as the dynamic transmit focusing could keep a good focusing quality at any depth. However, the SLSC image may still suffer a bad resolution performance when a low lag value is used in the coherence summation to ensure the contrast enhancement...
January 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28068830/work-life-balance-and-welfare
#9
Lois Evans, Greg Young
OBJECTIVES: An online survey and focus groups were conducted, providing qualitative information on the work-life balance of psychiatrists and trainees in Australasia. METHODS: An invitation to participate in an anonymous online welfare survey was emailed to all the Royal Australian and New Zealand College of Psychiatrists trainees, Fellows, and Affiliates. Following this, nine focus groups were held across Australia and New Zealand. RESULTS: Responses received were thematically analysed...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28068553/the-relationship-of-community-activities-with-cognitive-impairment-and-depressive-mood-independent-of-mobility-disorder-in-japanese-older-adults
#10
Mika Okura, Mihoko Ogita, Miki Yamamoto, Toshimi Nakai, Tomoko Numata, Hidenori Arai
AIM: This study aimed to examine the relationship of participating in community activities (CA) with cognitive impairment and depressive mood independent of mobility disorder (MD) among older Japanese people. METHODS: Elderly residents in institutions or those requiring long-term care insurance services were excluded; questionnaires were mailed to 5401 older adults in 2013. The response rate was 94.3% (n=5094). We used multiple imputation to manage missing data...
December 29, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28066979/when-proteostasis-goes-bad-protein-aggregation-in-the-cell
#11
REVIEW
Mona Radwan, Rebecca J Wood, Xiaojing Sui, Danny M Hatters
Protein aggregation is a hallmark of the major neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's and motor neuron and is a symptom of a breakdown in the management of proteome foldedness. Indeed, it is remarkable that under normal conditions cells can keep their proteome in a highly crowded and confined space without uncontrollable aggregation. Proteins pose a particular challenge relative to other classes of biomolecules because upon synthesis they must typically follow a complex folding pathway to reach their functional conformation (native state)...
January 9, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28065728/are-there-risk-factors-for-osseous-mandibular-inferior-border-defects-after-bilateral-sagittal-split-osteotomy
#12
J P Verweij, J G van Rijssel, M Fiocco, G Mensink, P J J Gooris, J P R van Merkesteyn
PURPOSE: Bone defects of the inferior mandibular border (osseous inferior border defects) can cause unesthetic postoperative outcomes after bilateral sagittal split osteotomy (BSSO). The aim of this study was to estimate the frequency of osseous inferior border defects after BSSO and to identify risk factors for this complication. MATERIALS AND METHODS: This retrospective study included consecutive patients who underwent BSSO for mandibular retrognathia. The primary outcome was the presence/absence of osseous inferior border defects...
December 21, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28064511/level-of-pain-and-quality-of-life-of-people-living-with-hiv-aids-pain-and-quality-of-life-in-hiv-aids
#13
Joelma Gomes da Silva, Dimas Anaximandro da Rocha Morgan, Flávia Cavalcante Monteiro Melo, Isis Kelly Dos Santos, Kesley Pablo Morais de Azevedo, Humberto Jefferson de Medeiros, Maria Irany Knackfuss
The aim of this descriptive study was to correlate the level of pain with the quality of life in 261 people living with HIV/AIDS. Mild pain/no pain was reported by 47.5% of subjects, 24.1% reported moderate pain, and 28.4% reported severe pain; pain levels were correlated with gender (p = 0.02), health status (p < 0.001), perception (p < 0.001), and stage of infection (p = 0.005). Being female represented a risk factor for moderate (p < 0.001) and intense pain (p = 0.004). Poor health represented a risk for moderate (p < 0...
January 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28064307/-the-cause-of-cancer-mutations-improvable-bad-life-or-inevitable-stochastic-replication-errors
#14
I V Alekseenko, A I Kuzmich, V V Pleshkan, D V Tyulkina, M V Zinovyeva, M B Kostina, E D Sverdlov
Despite substantial progress in understanding the mechanisms of carcinogenesis and fighting oncology diseases, cancer mortality remains rather high. Therefore, there is a striving to reduce this mortality to the level determined by endogenous biological factors. The review analyzes the mutations that lead to cell malignant transformation and describes the contribution that self-renewal of adult tissues makes to tumorigenesis. Cancer progression is considered as a development of a complicated system where cells mutate, evolve, and are subject to selection...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28064222/pulsed-electromagnetic-field-stimulation-promotes-anti-cell-proliferative-activity-in-doxorubicin-treated-mouse-osteosarcoma-cells
#15
Yoshitaka Muramatsu, Takuya Matsui, Masataka Deie, Keiji Sato
AIM: We aimed to investigate the synergistic effects of pulsed electromagnetic field (PEMF) and doxorubicin therapy in a mouse osteosarcoma cell line (LM8 cells) in vitro. MATERIALS AND METHODS: The effects of PEMF (5 mT, 200 Hz) of different durations and doxorubicin on the proliferative activity of LM8 cells were measured by the MTT assay. Apoptotic-related factors such as cell-cycle phase, mitochondrial membrane potential, and caspase 3/7 activity were investigated using 4',6-diamidino-2-phenylindole staining and apoptosis kits...
2, 2017: In Vivo
https://www.readbyqxmd.com/read/28064196/understanding-interactions-among-cephalometrics-variables-during-growth-in-untreated-class-iii-subjects
#16
Pietro Auconi, Marco Scazzocchio, Guido Caldarelli, Michele Nieri, James A McNamara, Lorenzo Franchi
OBJECTIVE: The aim of the present study was to apply a computational method commonly used in data mining discipline, classification trees (CTs), to evaluate the growth features in untreated Class III subjects. MATERIALS AND METHODS: CT was applied to data from 91 untreated Class III subjects (48 females and 43 males) and compared with the results of discriminant analysis (DA). For all subjects, lateral cephalograms were available at T1 (mean age 10.4 ± 2.0 years) and at T2 (mean age 15...
January 7, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28063663/why-good-is-more-alike-than-bad-processing-implications
#17
REVIEW
Hans Alves, Alex Koch, Christian Unkelbach
Humans process positive information and negative information differently. These valence asymmetries in processing are often summarized under the observation that 'bad is stronger than good', meaning that negative information has stronger psychological impact (e.g., in feedback, learning, or social interactions). This stronger impact is usually attributed to people's affective or motivational reactions to evaluative information. We present an alternative interpretation of valence asymmetries based on the observation that positive information is more similar than negative information...
January 4, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28063461/acceptability-of-self-sampling-in-portuguese-women-the-good-the-bad-or-the-ugly
#18
Jani Silva, Fátima Cerqueira, Rui Medeiros
Background: Self-sampling is a less costly approach that has been used for human papillomavirus (HPV) testing. Methods: A cross-sectional study involving 313 Portuguese women assessed the acceptability of cervicovaginal self-sampling. Results: Self-sampling was a well-accepted method [75.7%; 95% confidence interval (CI) 70.5-80.2], and the majority of women felt no pain (67.4%; 95% CI 61.9-72.5), no discomfort (70.9%; 95% CI 65.5-75.8) and no complexity (76.4%; 95% CI 71.2-80.9). The willingness to repeat self-sampling was high (89...
January 9, 2017: Sexual Health
https://www.readbyqxmd.com/read/28062472/is-having-a-family-member-with-chronic-health-concerns-bad-for-young-people-s-health-cross-sectional-evidence-from-a-national-survey-of-young-australians
#19
Anna K Moffat, Gerry Redmond
OBJECTIVES: Young people's perspectives on the association between having a family member with a chronic health concern (FHC) and their own health are under-researched. This study used young people's reports to assess the prevalence of FHCs and their association with negative health outcomes, with an aim of identifying potential inequalities between marginalised and non-marginalised young people. Family cohesion was examined as a moderating factor. DESIGN: Cross-sectional data from the Australian Child Wellbeing Project survey were used...
January 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28062345/tumor-talk-and-child-well-being-perceptions-of-good-and-bad-news-among-parents-of-children-with-advanced-cancer
#20
Angela M Feraco, Veronica Dussel, Liliana Orellana, Tammy I Kang, J Russell Geyer, Abby R Rosenberg, Chris Feudtner, Joanne Wolfe
CONTEXT: Little is known about how parents of children with advanced cancer classify news they receive about their child's medical condition. OBJECTIVE: To develop concepts of "good news" and "bad news" in discussions of advanced childhood cancer from parent perspectives. METHODS: Parents of children with advanced cancer cared for at three children's hospitals were asked to share details of conversations in the preceding 3 months that contained "good news" or "bad news" related to their child's medical condition...
January 3, 2017: Journal of Pain and Symptom Management
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