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https://www.readbyqxmd.com/read/28934713/imposex-levels-and-butyltin-compounds-bts-in-hexaplex-trunculus-linnaeus-1758-from-the-northern-adriatic-sea-italy-ecological-risk-assessment-before-and-after-the-ban
#1
Federica Cacciatore, Rossella Boscolo Brusà, Seta Noventa, Camilla Antonini, Vanessa Moschino, Malgorzata Formalewicz, Claudia Gion, Daniela Berto, Massimo Gabellini, Maria Gabriella Marin
The aim of this study was to compare imposex and butyltin compounds (BTs) data, collected before and after the organotin ban in 2008, in order to assess temporal and spatial variation of the phenomenon, the decline of BT contamination, and the effects on Hexaplex trunculus population in the coastal area of the northern Adriatic Sea, close to the Venice Lagoon. Both in marine and in lagoon sites, the results obtained in 2013-2015 showed a significant decline in the incidence of imposex in respect to those from the 2002 survey...
September 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28933921/are-you-ready-to-have-fun-the-spanish-state-form-of-the-state-trait-cheerfulness-inventory
#2
Raúl López-Benítez, Alberto Acosta, Juan Lupiáñez, Hugo Carretero-Dios
Although cheerfulness, seriousness, and bad mood as traits have been widely studied as the basis of sense of humor, data are scarce regarding the same dimensions as states. In this study, we adapted the state form of the State-Trait-Cheerfulness Inventory (STCI-S) into Spanish. At the same time, we empirically tested new predictions. We assessed 5 independent samples accounting for 1,029 participants (647 women) with ages ranging from 18 to 78 years. We confirmed the 3-dimensional structure as well as a strong measurement invariance between men and women...
September 21, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28933009/does-iris-in-bring-bad-news-or-good-news
#3
REVIEW
Silvio Buscemi, Davide Corleo, Carola Buscemi, Carla Giordano
Irisin, a novel myokine produced in response to physical activity, promotes white-to-brown fat transdifferentiation. The name irisin referred to the ancient Greek goddess Iris, the messenger who delivered (bad) news from the gods. In mice, it has been demonstrated that irisin plays a key role in metabolic regulation, energy expenditure and glucose homeostasis. New findings from various studies carried out in both animals and humans suggest that irisin might also have other favorable effects, such as increasing bone cortical mass, preventing hepatic lipid accumulation, and improving cognitive functions, thus mediating many exercise-induced health benefits...
September 20, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28931829/peer-punishment-promotes-enforcement-of-bad-social-norms
#4
Klaus Abbink, Lata Gangadharan, Toby Handfield, John Thrasher
Social norms are an important element in explaining how humans achieve very high levels of cooperative activity. It is widely observed that, when norms can be enforced by peer punishment, groups are able to resolve social dilemmas in prosocial, cooperative ways. Here we show that punishment can also encourage participation in destructive behaviours that are harmful to group welfare, and that this phenomenon is mediated by a social norm. In a variation of a public goods game, in which the return to investment is negative for both group and individual, we find that the opportunity to punish led to higher levels of contribution, thereby harming collective payoffs...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28931667/an-invisible-disease-severe-asthma-is-more-than-just-bad-asthma
#5
EDITORIAL
Sally E Wenzel, Sheila Brillhart, Kristin Nowack
No abstract text is available yet for this article.
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28929711/-statistics-at-the-time-of-the-crisis
#6
Andrea Saltelli, Philip B Stark
Science lies nowadays in the centre of several storms. The better known is the finding of non-reproducibility of many scientific results, which stretches from the medical field (clinic and pre-clinic tests) to study on behaviour (priming research). Although the bad use of statistics is reported to be a patent cause of the reproducibility crisis, its deep reasons are to be sought elsewhere; particularly, in the passage from a regimen of little science - regulated by small communities of researchers - to the current big science - identified by a hypertrophic production of millions of research papers and by the imperative "publish or perish", in a setting dominated by market...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929662/-effect-of-astragaloside-on-mrna-expression-of-pi3k-akt-mtor-signal-transduction-in-anemia-model-mice-induced-by-chemotherapy
#7
Tie Qiao, Ke Liang, Jin Ma, Shu-Ru Lin, Bing-Yuan Zheng, Li-de Zhang
To study the influence of astragaloside on mRNA expression of PI3K/Akt/mTOR signal transduction in anemia model mice induced by chemotherapy, 48 male BALB/c mice which were 6-7 week old were picked as the research objects and randomly divided into four groups, blank group, model group, astragaloside group and astragaloside IV group. Each group was 12 mice. Chemotherapy anemia model was established by cyclophosphamide. The mice were drawn blood from eyeball after 14 days treatment. The QPCR was used to test the mRNA concentrations of Akt, PI3K, BCL-xl, bad, FoxO, mTOR, PTEN in mouse spleen...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928875/microrna-216b-5p-functions-as-a-tumor-suppressive-rna-by-targeting-tpt1-in-pancreatic-cancer-cells
#8
Yu You, Jiaxin Tan, Yi Gong, Haisu Dai, Haowei Chen, Xuejun Xu, Aigang Yang, Yujun Zhang, Ping Bie
MicroRNAs (miRNAs) are increasingly recognized as being involved in pancreatic cancer progression by directly regulating the expression of their targets. In this study, we showed that miR-216b-5p expression was significantly decreased in pancreatic cancer tissues and cell lines. In addition, low miR-216b-5p expression was significantly associated with large tumor size and advanced TNM stage. Meanwhile, both Kaplan-Meier and multivariate survival analysis showed that decreased miR-216b-5p expression was associated with overall survival...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28927780/effects-of-metformin-on-proliferation-and-apoptosis-of-human-megakaryoblastic-dami-and-meg-01-cells
#9
Xue Liang, Peiyan Kong, Jin Wang, Yulin Xu, Chunfang Gao, Guozhen Guo
Metformin has received increasing attention for its potential anticancer activity against certain human leukemia cells, but its effects on human megakaryoblastic cells are unclear. This study aimed to investigate the effects of metformin on proliferation and apoptosis of human megakaryoblastic cells (Dami and MEG-01) and the underlying molecular mechanisms. CCK8 assay was employed to measure cell proliferation. Flow cytometry was adopted to detect cell apoptosis. Western blot was further employed to measure apoptosis-related proteins...
August 23, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28927134/primary-mucinous-adenocarcinoma-of-the-lung-a-case-report-and-review-of-the-literature
#10
Yan Liu, He-Long Zhang, Jia-Zhuan Mei, Yan-Wei Guo, Rui-Jun Li, Si-Dong Wei, Fu Tian, Lu Yang, Hui Wang
Mucinous adenocarcinoma is an unusual histological type of lung cancer, and its clinicopathological feature is distinctive from that of other histopathological types of lung adenocarcinoma. Mucinous adenocarcinoma has a mucus-producing function, which explains its name. The present study reports a rare case of a mucus-producing adenocarcinoma of the lung. A 60-year-old Chinese female patient was diagnosed with mucinous adenocarcinoma of the lung, which manifested as respiratory symptoms, including fever, cough and expectoration...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926722/innovation-in-care-for-individuals-with-cognitive-impairment-can-reimbursement-policy-spread-best-practices
#11
Soo Borson, Joshua Chodosh, Cyndy Cordell, Beth Kallmyer, Malaz Boustani, Anna Chodos, Jatin K Dave, Lisa Gwyther, Susan Reed, David B Reuben, Stephen Stabile, Monica Willis-Parker, William Thies
There is now an unprecedented opportunity to improve the care of the over 5 million people who are living with Alzheimer's disease and related dementias and many more with cognitive impairment due to brain injury, systemic diseases, and other causes. The introduction of a new Medicare care planning benefit-long sought openly by advocacy organizations and clinicians and badly needed by patients and families-could greatly improve health care quality, but only if widely and fully implemented. We describe the components of this new benefit and its promise of better clinical care, as well as its potential to create a new platform for clinical and health outcomes research...
September 16, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28926353/randomized-double-blind-placebo-and-active-comparator-controlled-crossover-study-evaluating-the-abuse-potential-of-the-antiepileptic-drug-lacosamide-in-healthy-recreational-drug-users
#12
Kerri A Schoedel, Jens-Otto Andreas, Pamela Doty, Klaus Eckhardt, Edward M Sellers
PURPOSE: This phase 1, randomized, double-blind, placebo- and active comparator-controlled crossover study assessed the abuse potential of the antiepileptic drug, lacosamide. METHODS: After a qualification phase, 38 healthy, recreational central nervous system-depressant users were randomized to treatment sequences comprising single oral therapeutic (200 mg) and supratherapeutic (800 mg) doses of lacosamide, alprazolam (1.5 and 3 mg), and placebo. Subjective effects were assessed for 24 hours following each dose using a range of scales, with a 5- to 9-day washout between treatments...
September 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28926159/randomized-controlled-feasibility-trial-of-intranasal-ketamine-compared-to-intranasal-fentanyl-for-analgesia-in-children-with-suspected-extremity-fractures
#13
Stacy L Reynolds, Kathleen K Bryant, Jonathan R Studnek, Melanie Hogg, Connell Dunn, Megan A Templin, Charity G Moore, James R Young, Katherine Rivera Walker, Michael S Runyon
OBJECTIVE: We compared the tolerability and efficacy of intranasal sub-dissociative ketamine to intranasal fentanyl for analgesia of children with acute traumatic pain and investigated the feasibility of a larger non-inferiority trial that could investigate the potential opioid sparing effects of intranasal ketamine. METHODS: This randomized controlled trial compared intranasal ketamine 1 mg/kg to intranasal fentanyl 1.5 μg/kg in children 4-17 years old with acute pain from suspected, isolated extremity fractures presenting to an urban level II pediatric trauma center from December 2015 to November 2016...
September 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28925978/dental-environmental-noise-evaluation-and-health-risk-model-construction-to-dental-professionals
#14
Kuen Wai Ma, Hai Ming Wong, Cheuk Ming Mak
Occupational noise is unavoidably produced from dental equipment, building facilities, and human voices in the dental environment. The purpose of this study was to investigate the effect of occupational noise exposure on the dental professionals' health condition. The psychoacoustics approach noise exposure assessment followed by the health risk assessment was carried on at the paediatric dentistry clinic and the dental laboratory in the Prince Philip Dental Hospital of Hong Kong. The A-weighted equivalent sound level, total loudness, and sharpness values were statistically significantly higher for the noise at the laboratory than that at the clinic...
September 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28924687/comskil-communication-training-in-oncology-adaptation-to-german-cancer-care-settings
#15
Tim J Hartung, David Kissane, Anja Mehnert
Medical communication is a skill which can be learned and taught and which can substantially improve treatment outcomes, especially if patients' communication preferences are taken into account. Here, we give an overview of communication training research and outline the COMSKIL program as a state-of-the-art communication skills training in oncology. COMSKIL has a solid theoretical foundation and teaches core elements of medical communication in up to ten fully operationalized modules. These address typical situations ranging from breaking bad news to responding to difficult emotions, shared decision-making, and communicating via interpreters...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#16
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28923633/changes-in-dna-methylation-of-glucocorticoid-induced-tumor-necrosis-factor-receptor-and-its-ligand-in-liver-transplantation
#17
W Wang, G Ji, Y Chen, J Wang, J Sun, G Tang, Z Xie, H Zhao, G Liu, S Tan, G Chen, H Xue
Liver transplantation (LT) is the criterion standard of care in patients with end-stage liver disease and those with tumors of hepatic origin in the setting of liver dysfunction. Chronic immune rejection of the liver transplant can lead to bad prognosis for patients. Glucocorticoid-induced tumor necrosis factor receptor (GITR) play a key role in dominant immunologic self-tolerance maintained by CD25+/CD4+ regulatory T cells. Here, we investigated the DNA methylation variations of GITR and GITR ligand (GITRL) using pyrosequencing by analyzing blood DNA samples of patients after LT...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923578/coastal-dynamics-vs-beach-users-attitudes-and-perceptions-to-enhance-environmental-conservation-and-management-effectiveness
#18
Roberta Aretano, Luca Parlagreco, Teodoro Semeraro, Giovanni Zurlini, Irene Petrosillo
This work carries out a landscape analysis for the last 60years to compare the degree of preservation of two areas on the same Italian coastline characterized by different environmental protection levels: a National designated protected areas and a highly tourist coastal destination. The conversion of natural land-covers into human land uses were detected for protected and unprotected coastal stretches highlighting that the only establishment of a protected area is not enough to stem undesirable land-use outcomes...
September 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28923577/quality-index-of-the-surface-water-of-amazonian-rivers-in-industrial-areas-in-par%C3%A3-brazil
#19
Adaelson Campelo Medeiros, Kleber Raimundo Freitas Faial, Kelson do Carmo Freitas Faial, Iris Danielly da Silva Lopes, Marcelo de Oliveira Lima, Raphael Mendonça Guimarães, Neyson Martins Mendonça
In this study was to evaluate the waters quality of the Murucupi River, located in urban agglomerate area and intense industrial activity in Barcarena City, Pará State. The Arapiranga River in Abaetetuba City was used as control area (Background), next to Barcarena. Was used the Water Quality Index (WQI) based on nine variables analized. Waters quality of the Arapiranga and Murucupi rivers were regular to good and bad to good, respectively. Anthropogenic influence on the Murucupi River was higher, mainly by the disposal of domestic effluents from the urban agglomerate and of the industrial waste tailing basins upstream of this river...
September 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28922662/treatment-of-autoimmune-glial-fibrillary-acidic-protein-astrocytopathy-follow-up-in-7-cases
#20
Xinguang Yang, Junyan Liang, Qingmei Huang, Huiming Xu, Cong Gao, Youming Long, Xiaoyu Xiao
OBJECTIVE: The aim of this work was to report an autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy with long-term follow-up in 7 patients. METHODS: Antibodies were detected by indirect immunofluorescence assay and patient data were analyzed retrospectively. RESULTS: Seven patients (4 female, 3 male) with ≥1 year follow-up were included. All patients had positive GFAP antibodies in their cerebral spinal fluid (CSF). Their median age at disease onset was 56 years (range 27-69) and the median disease duration was 1 year (range 1-4)...
September 19, 2017: Neuroimmunomodulation
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