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https://www.readbyqxmd.com/read/29145367/daca-s-demise-is-bad-for-our-health
#1
Sahand Ghodrati
No abstract text is available yet for this article.
November 14, 2017: Scientific American
https://www.readbyqxmd.com/read/29145275/asymptomatic-syringomyelia-accompanied-with-metastatic-cerebellar-and-spinal-intramedullary-lymphoma-a-case-report
#2
Jia-Jia Zhou, Jin-Feng Xu, Xu-Ning Zheng, Guo-Ping Peng
RATIONALE: Asympotamic syringomyelia accompanied with metastatic cerebellar and thoracic spinal intramedullary lymphoma is rare in clinical practice. If the intramedullary lymphoma is large enough, the patient will rapidly develop neurologic signs of spinal injury. The prognosis of this type of complication is always bad. PATIENT CONCERNS: Rapid and correct diagnosis and treatment is important for metastatic extranodal lymphoma with B cell of origin. DIAGNOSES: Syringomyelia accompanied with metastatic cerebellar and thoracic spinal intramedullary lymphoma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145271/tug1-spry4-it1-and-hulc-as-valuable-prognostic-biomarkers-of-survival-in-cancer-a-prisma-compliant-meta-analysis
#3
Yucheng Zhong, Zhicong Chen, Shuyuan Guo, Xinhui Liao, Haibiao Xie, Yien Zheng, Bin Cai, Peixian Huang, Yuhan Liu, Qun Zhou, Yuchen Liu, Weiren Huang
BACKGROUND: Long noncoding RNAs (LncRNAs) are involved in the development and progression of various cancers. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors. METHODS: Here, 3 well-known lncRNAs associated with cancer were gathered to prove the potential role of lncRNAs as novel predictors of survival in human cancer. This meta-analysis collected all eligible studies about TUG1, SPRY4-IT1, and HULC and explored the relationship between lncRNAs expression and lymph node metastasis (LNM) or overall survival (OS)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145137/uncertainty-in-positive-matrix-factorization-solutions-for-pahs-in-surface-sediments-of-the-yangtze-river-estuary-in-different-seasons
#4
Ruimin Liu, Cong Men, Wenwen Yu, Fei Xu, Qingrui Wang, Zhenyao Shen
To examine the variabilities of source contributions in the Yangtze River Estuary (YRE), the uncertainty based on the positive matrix factorization (PMF) was applied to the source apportionment of the 16 priority PAHs in 120 surface sediment samples from four seasons. Based on the signal-to-noise ratios, the PAHs categorized as "Bad" might drop out of the estimation of bootstrap. Next, the spatial variability of residuals was applied to determine which species with non-normal curves should be excluded. The median values from the bootstrapped solutions were chosen as the best estimate of the true factor contributions, and the intervals from 5th to 95th percentile represent the variability in each sample factor contribution...
October 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/29144503/mait-cells-in-type-1-diabetes-a-good-friend-turned-bad
#5
Lina Petersone, Lucy S K Walker
No abstract text is available yet for this article.
November 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29143780/who-participates-in-running-events-socio-demographic-characteristics-psychosocial-factors-and-barriers-as-correlates-of-non-participation-a-pilot-study-in-belgium
#6
Delfien van Dyck, Greet Cardon, Ilse de Bourdeaudhuij, Lisa de Ridder, Annick Willem
In Western countries, the popularity of running events has increased exponentially during the last three decades. However, little is known about the profile of non-participants. This knowledge is crucial to tailor promotional actions towards people who are currently not participating. Therefore, this study aimed: (1) to examine which socio-ecological factors are related to participation in running events, (2) to give an overview of the barriers towards participation, and (3) to examine differences in barriers depending on gender, age and educational level...
October 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29143090/pattern-of-lower-intestinal-ostomies-in-a-low-income-country-case-of-southeast-of-niger-republic
#7
Harissou Adamou, Oumarou Habou, Ibrahim Amadou Magagi, Ousseini Adakal, Amadou Magagi, Maazou Halidou, Rachid Sani
BACKGROUND: Intestinal ostomies are common surgical procedures performed in visceral surgery as part of management for several gastrointestinal diseases. This study aims to report the socio-demographic characteristics, indications and prognosis of intestinal ostomies in low-income country. METHODS: This was a 4-year retrospective study (January 2013 to December 2016) at Zinder National Hospital (Niger). All patients with a digestive ostomy on an ileum or colic segment were included in the study...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29142990/the-chemical-chaperone-pba-reduces-er-stress-and-autophagy-and-increases-collagen-iv-%C3%AE-5-expression-in-cultured-fibroblasts-from-men-with-x-linked-alport-syndrome-and-missense-mutations
#8
Dongmao Wang, Mardhiah Mohammad, Yanyan Wang, Rachel Tan, Lydia S Murray, Sharon Ricardo, Hayat Dagher, Tom van Agtmael, Judy Savige
Introduction: X-linked Alport syndrome (OMIM 301050) is caused by COL4A5 missense variants in 40% of families. This study examined the effects of chemical chaperone treatment (sodium 4-phenylbutyrate) on fibroblast cell lines derived from men with missense mutations. Methods: Dermal fibroblast cultures were established from 2 affected men and 3 normals. Proliferation rates were examined, the collagen IV α5 chain localized with immunostaining, and levels of the intra- and extracellular chains quantitated with an in-house enzyme-linked immunosorbent assay...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142424/apoptotic-effect-of-nigella-sativa-on-human-lymphoma-u937-cells
#9
Belkis Atasever Arslan, Fatma Busra Isik, Hazal Gur, Fatih Ozen, Tunc Catal
Objective: Nigella sativa is from botanical Ranunculaceae family and commonly known as black seed. Apoptotic effect of N. sativa and its apoptotic signaling pathways on U937 lymphoma cells are unknown. Materials and Methods: In this study, we investigated selective cytotoxic and apoptotic effects of N. sativa extract and its apoptotic mechanisms on U937 cells. In addition, we also studied selective cytotoxic activity of thymoquinone that is the most active essential oil of N...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142412/tyrosinase-inhibitory-activities-of-carissa-opaca-stapf-ex-haines-roots-extracts-and-their-phytochemical-analysis
#10
Wajeeha Malik, Dildar Ahmed, Sania Izhar
Objective: Carissa opaca is a medicinal plant with rich folkloric applications. The present research was conducted to explore the tyrosinase inhibitory potential of aqueous decoction (AD) and methanolic extract (ME) of roots of C. opaca and its fractions in various solvents and their phytochemical analysis. Materials and Methods: AD of the dried powdered roots of C. opaca was prepared by boiling in water. ME was prepared by cold maceration. Its fractions were obtained in solvents of increasing polarity, i...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141794/short-term-outcome-of-adem-results-from-a-retrospective-cohort-study-from-south-india
#11
Mary Iype, P A Mohammed Kunju, Geetha Saradakutty, T S Anish, Mini Sreedharan, Shahanaz M Ahamed
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM), an immune mediated inflammatory disease is common in children. The profile and immediate outcome of children hospitalized with ADEM is scarce in the available literature. OBJECTIVES: We aimed to study the clinical profile of children with ADEM and to look for prognostic factors for outcome at discharge from hospital METHODS: We chose a retrospective cohort study of all children diagnosed with ADEM at our institution between January 2006 and December 2015, and they were evaluated, after excluding other diagnoses when they were summoned for a follow up visit...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141197/medical-abortion-reversal-science-and-politics-meet
#12
Khadijah Z Bhatti, Antoinette T Nguyen, Gretchen S Stuart
Medical abortion is a safe, effective, and acceptable option for patients seeking an early non-surgical abortion. In 2014, medical abortion accounted for nearly one-third (31%) of all abortions performed in the United States. State-level attempts to restrict reproductive and sexual health have recently included bills that require physicians to inform women that a medical abortion is reversible. In this commentary, we will review the history, current evidence-based regimen, and regulation of medical abortion...
November 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29140260/vaccinia-virus-natural-infections-in-brazil-the-good-the-bad-and-the-ugly
#13
REVIEW
Jaqueline Silva de Oliveira, Poliana de Oliveira Figueiredo, Galileu Barbosa Costa, Felipe Lopes de Assis, Betânia Paiva Drumond, Flávio Guimarães da Fonseca, Maurício Lacerda Nogueira, Erna Geessien Kroon, Giliane de Souza Trindade
The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remain unknown. VACV was the primary component of the smallpox vaccine, largely used during the smallpox eradication campaign. After smallpox was declared eradicated, the vaccination that conferred immunity to OPV was discontinued, favoring a new contingent of susceptible individuals to OPV...
November 15, 2017: Viruses
https://www.readbyqxmd.com/read/29139225/oolong-tea-prevents-cardiomyocyte-loss-against-hypoxia-by-attenuating-p-jnk-mediated-hypertrophy-and-enhancing-p-igf1r-p-akt-and-p-bad-ser136-activity-and-by-fortifying-nrf2-antioxidation-system
#14
Marthandam Asokan Shibu, Chia-Hua Kuo, Bih-Cheng Chen, Da-Tong Ju, Ray-Jade Chen, Chao-Hung Lai, Pei-Jane Huang, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Tea, the most widely consumed natural beverage has been associated with reduced mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing high levels of catechins, their degree of oxidation varies between 20%-80% causing differences in their active metabolites. In this study we examined the effect of oolong tea extract (OTE) obtained by oxidation at low-temperature for short-time against hypoxic injury and found that oolong tea provides cyto-protective effects by suppressing the JNK mediated hypertrophic effects and by enhancing the innate antioxidant mechanisms in neonatal cardiomyocytes and in H9c2 cells...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29139079/neuromodulatory-procedures-for-gait-disorders-in-parkinson-s-disease
#15
REVIEW
Patrick Santens
The neurophysiology of gait is complex and involves numerous structures in the central nervous system. Gait disorders occur frequently in Parkinson's disease (PD), and their management may become cumbersome, especially in the more advanced stages. Neuromodulatory treatments, including deep brain stimulation, cortical stimulation and spinal cord stimulation, are reviewed with respect to their effectiveness to improve gait in PD patients. Although positive effects have been reported for all of these procedures, many issues remain in view of methodological heterogeneity, variability in outcome measures and sample size...
November 14, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29138173/cardiovascular-preventive-care-for-patients-with-serious-mental-illness
#16
Sarah Ritchie, Laura Muldoon
OBJECTIVE: To determine whether patients with serious mental illness (SMI) are receiving preventive care for cardiovascular disease at the same rate as those without SMI in an interprofessional practice with a mandate to care for persons with barriers to access to the health care system. DESIGN: Quality improvement exercise using a case-matched retrospective chart review. SETTING: Somerset West Community Health Centre in downtown Ottawa, Ont...
November 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29136764/cardiac-apoptosis-induced-under-high-glucose-condition-involves-activation-of-igf2r-signaling-in-h9c2-cardiomyoblasts-and-streptozotocin-induced-diabetic-rat-hearts
#17
Chih-Chung Feng, Sudhir Pandey, Ching-Yuang Lin, Chia-Yao Shen, Ruey-Lin Chang, Tung-Ti Chang, Ray-Jade Chen, Vijaya Padma Viswanadha, Yueh-Min Lin, Chih-Yang Huang
The insulin-like growth factor type 2 receptor (IGF2R) overexpression has been implicated in heart disease progression. Unregulated IGF2R signaling triggers cardiac hypertrophy, apoptosis, and cardiomyopathies. The present study investigated the role of IGF2R in cardiomyocyte apoptosis under high glucose (HG) levels and in streptozotocin (STZ) induced diabetic rat hearts. We found that IGF2 and IGF2R protein expression were highly upregulated under high glucose condition in H9c2 cells as well as in STZ induced diabetic rat hearts...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29135144/-the-use-of-prostadoz-in-patients-with-benign-prostatic-hyperplasia-and-coexistent-high-grade-prostatic-intraepithelial-neoplasia
#18
A G Antonov, V V Gordeev, S B Fedorchuk, D O Laptev
INTRODUCTION: In recent years there has been an increasing interest in the drug treatment of benign prostatic hyperplasia (BPH) to improve the patients quality of life without surgical treatment. In this connection, phytotherapeutic drugs and biologically active dietary supplements (BADS), consisting of a combination of microelements, vitamins and plant extracts, have been increasingly used in addition to synthetic preparations. OBJECTIVE: To investigate the clinical effectiveness of dietary supplement ProstaDoz in the treatment of BPH with coexistent high-grade prostatic intraepithelial neoplasia (PIN)...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29134707/reproducibility-of-diagnostic-criteria-associated-with-atypical-breast-cytology
#19
J Weigner, I Zardawi, S Braye, P McElduff
OBJECTIVE: The aim of this project was to assess the interobserver and intraobserver variability when identifying cytological criteria, which were found to have a statistically significant association with C3 within a workplace environment. METHODS: Sixty C3 cases with known endpoints of malignant, benign proliferative or benign non-proliferative diagnoses were blindly and independently screened by seven experienced cytologists to identify previously reported statistically significant criteria associated with the C3 category...
November 14, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29134113/research-advances-in-kinase-enzymes-and-inhibitors-for-cardiovascular-disease-treatment
#20
REVIEW
Rand Shahin, Omar Shaheen, Faris El-Dahiyat, Maha Habash, Sana Saffour
The targeting of protein kinases has great future potential for the design of new drugs against cardiovascular diseases (CVDs). Enormous efforts have been made toward achieving this aim. Unfortunately, kinase inhibitors designed to treat CVDs have suffered from numerous limitations such as poor selectivity, bad permeability and toxicity. So, where are we now in terms of discovering effective kinase targeting drugs to treat CVDs? Various drug design techniques have been approached for this purpose since the discovery of the inhibitory activity of Staurosporine against protein kinase C in 1986...
November 2017: Future Science OA
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