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https://www.readbyqxmd.com/read/28437544/polypharmacy-in-the-elderly-when-good-drugs-lead-to-bad-outcomes-a-teachable-moment
#1
Casey Carroll, Ahmed Hassanin
No abstract text is available yet for this article.
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28437212/the-impact-of-communication-skills-training-on-cardiology-fellows-and-attending-physicians-perceived-comfort-with-difficult-conversations
#2
Kathryn Berlacher, Robert M Arnold, Eva Reitschuler-Cross, Jeffrey Teuteberg, Winifred Teuteberg
BACKGROUND: Cardiologists need to decide which treatments are appropriate for seriously ill patients and whether they align with patient goals. Reconciling medical options with patients' wishes requires skilled communication. Although there is evidence that communication is teachable, few cardiologists receive formal training. OBJECTIVE: To demonstrate that providing communication skills training to cardiologists is feasible and improves their perceived preparedness (PP) for leading difficult conversations...
March 1, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28435363/lightness-chroma-and-hue-distributions-in-natural-teeth-measured-by-a-spectrophotometer
#3
Teuta Pustina-Krasniqi, Kujtim Shala, Gloria Staka, Teuta Bicaj, Enis Ahmedi, Linda Dula
OBJECTIVE: The aim of the study was to analyze the distribution of color parameters, lightness (L*), chroma (C), hue (H), a* and b*, in the intercanine sector in maxilla. MATERIAL AND METHODS: Patients' tooth color measurements were performed using an intraoral spectrophotometer VITA Easyshade(®) (VITA Zahnfabrik H. Rauter GmbH and Co. KG, Bad Sackingen, Germany). The measurements were made in 255 subjects in the intercanine sector in maxilla. RESULTS: The mean values for the group of 255 subjects were as follows: L*, a*, b*, C, and H as 81...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28435362/awareness-about-the-effects-of-tobacco-consumption-on-oral-health-and-the-possibility-of-smoking-behavior-among-male-saudi-schoolchildren
#4
Muhammad Ashraf Nazir, Khalid Almas
OBJECTIVE: To investigate an association between the awareness about the effects of tobacco consumption on oral health and the likelihood of smoking among male schoolchildren. MATERIALS AND METHODS: A cross sectional study was conducted using a multistage random sampling technique. The participants (ages 15-19 years) were recruited from male public high schools in Greater Dammam in Saudi Arabia. A pretested questionnaire inquired participants' awareness about the effects of smoking on oral health...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434418/beliefs-and-attitudes-towards-the-influenza-vaccine-in-high-risk-individuals
#5
A J Santos, I Kislaya, A Machado, B Nunes
Societal and economic impact of influenza is mainly due to influenza infection of specific groups, who are at higher risk of health complications leading up to hospitalisation or death. In this study we applied the health belief model (HBM) to evaluate beliefs and attitudes towards influenza disease and vaccine in community-dwelling high-risk individuals (aged 65 or more or having a chronic disease). We conducted a mixed-method study using data collected through a telephone survey of a household unit sample...
April 24, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28433402/sensing-bad-are-co-stimulatory-car-expressing-%C3%AE-%C3%AE-t-cells-safer
#6
Robin Parihar
No abstract text is available yet for this article.
April 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28433364/belts-evaluated-as-limb-tourniquets-belt-study-comparing-trouser-supporters-used-as-medical-devices-in-a-manikin-model-of-wound-bleeding
#7
Blake W Bequette, John F Kragh, James K Aden, Michael A Dubick
OBJECTIVE: The purpose of the present study is to compare several models of commercially designed belts as used as a tourniquet. METHODS: In the Belts Evaluated as Limb Tourniquets (BELT) study, an experiment was designed to test the effectiveness of pants belts as nonimprovised medical devices to control hemorrhage in a manikin. Models of belts included Tourni-belt, Tourniquet Belt, ParaBelt, and Battle Buddy. Data collected included effectiveness, time to stop bleeding, total time of application, pressure, blood loss, and composite results (score count of good results; composite outcome good if every component was good)...
April 19, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28431825/single-subcortical-infarct-pathomechanism-assessed-by-thin-section-computed-tomography-perfusion
#8
Dong Hoon Shin, Ernst Klotz, Eung Yeop Kim
INTRODUCTION: The pathomechanism of a single subcortical infarct (SSI) may be better determined by assessing the perfusion status between parent artery and ischemic lesion. We aimed to compare the classifications into branch atheromatous disease (BAD) versus non-BAD based on diffusion-weighted imaging (DWI) or computed tomography perfusion (CTP), and to test whether a CTP-based classification improves the predicting power for progression in SSI (PSSI) compared to that by DWI. METHODS: We enrolled 109 consecutive patients with SSI examined by whole-supratentorial brain CTP and follow-up DWI...
April 18, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28428163/public-response-to-scientific-misconduct-assessing-changes-in-public-sentiment-toward-the-stimulus-triggered-acquisition-of-pluripotency-stap-cell-case-via-twitter
#9
Alberto Gayle, Motomu Shimaoka
BACKGROUND: In this age of social media, any news-good or bad-has the potential to spread in unpredictable ways. Changes in public sentiment have the potential to either drive or limit investment in publicly funded activities, such as scientific research. As a result, understanding the ways in which reported cases of scientific misconduct shape public sentiment is becoming increasingly essential-for researchers and institutions, as well as for policy makers and funders. In this study, we thus set out to assess and define the patterns according to which public sentiment may change in response to reported cases of scientific misconduct...
April 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28427732/endogenous-bacterial-endophthalmitis-a-report-of-2cases
#10
M Cubillas, A Sampedro, B Domínguez, I Carrio, V Bango, J J Barbón
CLINICAL CASES: The cases are presented on 2patients with bacterial endogenous endophthalmitis. The first one was caused by Streptococcus bovis, developed after colonoscopy, which had a poor outcome and resulted in evisceration. The second case was caused by a methicillin resistant Staphylococcus aureus from an arthrodesis complicated with a para-spinal abscess. It had an excellent visual outcome. DISCUSSION: Bacterial endogenous endophthalmitis is a rare, but serious ocular disease that occurs when bacteria reach the eye via the bloodstream...
April 17, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28426734/study-of-deaths-by-suicide-of-homosexual-prisoners-in-nazi-sachsenhausen-concentration-camp
#11
Esther Cuerda-Galindo, Francisco López-Muñoz, Matthis Krischel, Astrid Ley
Living conditions in Nazi concentration camps were harsh and inhumane, leading many prisoners to commit suicide. Sachsenhausen (Oranienburg, Germany) was a concentration camp that operated from 1936 to 1945. More than 200,000 people were detained there under Nazi rule. This study analyzes deaths classified as suicides by inmates in this camp, classified as homosexuals, both according to the surviving Nazi files. This collective was especially repressed by the Nazi authorities. Data was collected from the archives of Sachsenhausen Memorial and the International Tracing Service in Bad Arolsen...
2017: PloS One
https://www.readbyqxmd.com/read/28426397/a-successful-debrief-program-for-house-staff
#12
Victoria Leff, Adrienne Klement, Anthony Galanos
Challenging end-of-life encounters can be stressful and may lead to burnout. Monthly debriefing sessions are led by a physician and clinical social worker (LCSW). Sessions focus on experiences and emotional reactions rather than case details. Themes identified included; feeling unsupported after difficult deaths, identifying with patients emotionally, and conceptualizing a "good" versus "bad" death. Debriefing provides opportunities for residency physicians to reflect on the affective side of their work and helps promote resiliency...
April 20, 2017: Journal of Social Work in End-of-life & Palliative Care
https://www.readbyqxmd.com/read/28425886/an-overview-of-teaching-communication-of-bad-news-in-medical-school-should-a-lecture-be-adequate-to-address-the-topic
#13
Filipe Coutinho, Anisha Ramessur
INTRODUCTION: Delivering bad news is very common in medical daily practice. Several studies have shown a lack of effective communication skills amongst medical students, particularly concerning how to deliver bad news. The SPIKES protocol allows communicating bad news in a 6-step method. The aim of this study is to investigate the perspective of students related to this subject. MATERIAL AND METHODS: A 45 minute lecture "Breaking Bad News" was given to 160 students in the fifth and sixth years of the Medicine course, using the SPIKES' protocol training...
December 30, 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28425745/when-good-is-stickier-than-bad-understanding-gain-loss-asymmetries-in-sequential-framing-effects
#14
Jehan Sparks, Alison Ledgerwood
Considerable research has demonstrated the power of the current positive or negative frame to shape people's current judgments. But humans must often learn about positive and negative information as they encounter that information sequentially over time. It is therefore crucial to consider the potential importance of sequencing when developing an understanding of how humans think about valenced information. Indeed, recent work looking at sequentially encountered frames suggests that some frames can linger outside the context in which they are first encountered, sticking in the mind so that subsequent frames have a muted effect...
April 20, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28425196/bad-blood-contaminating-germline-databases
#15
Jane E Churpek
No abstract text is available yet for this article.
May 2017: Human Mutation
https://www.readbyqxmd.com/read/28425183/associations-between-major-life-events-and-adherence-glycemic-control-and-psychosocial-characteristics-in-teens-with-type-1-diabetes
#16
Persis V Commissariat, Lisa K Volkening, Zijing Guo, Jessica L ElBach, Deborah A Butler, Lori M Laffel
AIMS: This cross-sectional study assessed the type of major life events occurring in a contemporary sample of teens with type 1 diabetes and the association between event frequency and demographic, diabetes management, and psychosocial characteristics. METHODS: Parents of 178 teens completed the Life Events Checklist to report major events teens had experienced in the last year: 42% experienced 0 to 1 event (n = 75), 32% experienced 2 to 3 events (n = 57), and 26% experienced 4+ events (n = 46)...
April 19, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28423695/ndrg2-promotes-adriamycin-sensitivity-through-a-bad-p53-complex-at-the-mitochondria-in-breast-cancer
#17
Yifang Wei, Shentong Yu, Yongping Zhang, Yuan Zhang, Huadong Zhao, Zhixiong Xiao, Libo Yao, Suning Chen, Jian Zhang
Chemo-resistance presents a difficult challenge for the treatment of breast cancer. Our previous study showed that N-Myc downstream-regulated gene 2 (NDRG2) is involved in p53-mediated apoptosis induced by chemotherapy, through a mechanism that has so far remained obscure. Here, we explored the role of NDRG2 in chemo-resistance with a focus on Adriamycin (ADR) and found that NDRG2 expression decreased in ADR resistance breast cancer cells. Interestingly, NDRG2 can promote ADR sensitivity by inhibiting proliferation, enhancing cellular damage responses, and promoting apoptosis in a p53-dependent manner...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423649/stellettin-b-induces-apoptosis-in-human-chronic-myeloid-leukemia-cells-via-targeting-pi3k-and-stat5
#18
Yali Chen, Qianxiang Zhou, Lei Zhang, Yuxu Zhong, Guanwei Fan, Zhe Zhang, Ran Wang, Meihua Jin, Yuling Qiu, Dexin Kong
Novel agents are still urgently expected for therapy of chronic myeloid leukemia (CML). The in vitro anti-leukemia activity of Stellettin B (Stel B), a triterpenoid we isolated from marine sponge Jaspis stellifera, on human CML K562 and KU812 cells was recently investigated. Stel B inhibited K562 and KU812 cell proliferation with IC50 as 0.035 μM and 0.95 μM respectively. While no obvious cell cycle arrest was observed, apoptosis was induced in K562 cells after Stel B treatment. The Stel B-induced apoptosis might be in mitochondrial pathway, with increase of Bad and Bax, decrease of Bcl-2 and activation of caspase-9...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423593/anti-cancer-effect-of-novel-pak1-inhibitor-via-induction-of-puma-mediated-cell-death-and-p21-mediated-cell-cycle-arrest
#19
Tae-Gyun Woo, Min-Ho Yoon, Shin-Deok Hong, Jiyun Choi, Nam-Chul Ha, Hokeun Sun, Bum-Joon Park
Hyper-activation of PAK1 (p21-activated kinase 1) is frequently observed in human cancer and speculated as a target of novel anti-tumor drug. In previous, we also showed that PAK1 is highly activated in the Smad4-deficient condition and suppresses PUMA (p53 upregulated modulator of apoptosis) through direct binding and phosphorylation. On the basis of this result, we have tried to find novel PAK1-PUMA binding inhibitors. Through ELISA-based blind chemical library screening, we isolated single compound, IPP-14 (IPP; Inhibitor of PAK1-PUMA), which selectively blocks the PAK1-PUMA binding and also suppresses cell proliferation via PUMA-dependent manner...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422575/cardiovascular-risk-factors-of-long-term-care-workers
#20
Kelly Doran, Barbara Resnick
Little is known about long-term care workers' cardiovascular disease (CVD) risk. Thus, the authors used baseline objective and subjective data from 98 long-term care staff participating in a worksite health promotion study to provide a comprehensive CVD assessment. The median age of the sample was 32 years ( SD = 13.38). Nine (12.2%) participants smoked and 27 (37.0%) participants reported exposure to secondhand smoke. The average nightly hours of sleep was 6.5 ( SD = 1.18), with 24 (32%) participants reporting sleeping at least fairly bad...
April 1, 2017: Workplace Health & Safety
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