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https://www.readbyqxmd.com/read/29334280/comparison-of-guidelines-for-the-use-of-tnf-inhibitors-for-psoriasis-in-the-united-states-canada-europe-and-the-united-kingdom-a-critical-appraisal-and-comprehensive-review
#1
Vidhi V Shah, Erica B Lee, Shivani Reddy, Elaine J Lin, Jashin J Wu
PURPOSE: To compare and contrast evidence-based CPGs from leading dermatological organizations for the use of tumor necrosis factor inhibitors (TNFi) in psoriasis. MATERIALS AND METHODS: Guidelines from the British National Institute for Health and Care Excellence (NICE), the British Association of Dermatologists (BAD), the American Academy of Dermatology (AAD), the National Psoriasis Foundation (NPF), and the Canadian Dermatology Association (CDA) were reviewed and compared...
January 15, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29333831/-mammary-hemangioma-in-an-infant-with-apparent-mastitis-case-report
#2
Cristina Rodríguez Jiménez, Concepción Míguez Navarro, Minia Campos Domínguez, Carmen Garrido Colino
Mammary pathology is infrequent during childhood. It is rare the probability of finding a breast mass in an infant. The most frequent possible diagnoses at this age are breast abscess, mastitis, breast engorgement due to maternal hormonal stimulation and hemangioma. Reaching the proper diagnosis is essential in order to apply a suitable treatment and avoid the potential disease complications. We present the case of a female infant having a mass in the right breast from birth. Initially the entity was treated as mastitis...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333679/publication-ethics-where-are-we-today-part-3-the-good-the-bad-and-the-ugly-face-of-publication
#3
EDITORIAL
Lin Perry
No abstract text is available yet for this article.
December 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29333657/gelatin-methacryloyl-hydrogels-in-the-absence-of-a-crosslinker-as-3d-glioblastoma-multiforme-gbm-mimetic-microenvironment
#4
Pelin Erkoc, Fidan Seker, Tugba Bagci-Onder, Seda Kizilel
3D platforms are important for monitoring tumor progression and screening drug candidates to eradicate tumors such as glioblastoma multiforme (GBM), a malignant type of human brain tumor. Here, a new strategy is reported that exploits visible-light-induced crosslinking of gelatin where the reaction is carried out in the absence of an additional crosslinker. Visible light-induced crosslinking promotes the design of cancer microenvironment-mimetic system without compromising the cell viability during the process and absence of crosslinker facilitates the synthesis of the unique construct...
January 15, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29332562/the-delicate-balance-between-the-good-and-the-bad-il-1-proinflammatory-effects-in-endometriosis
#5
Justyna Sikora, Simone Ferrero, Aleksandra Mielczarek-Palacz, Zdzislawa Kondera-Anasz
BACKGROUND: Endometriosis is an inflammatory gynaecological disease with an associated chronic inflammation. Interleukin(IL)-1 is one of the most important immune and proinflammatory factors, produced mainly by monocytes and macrophages. Studies indicate the role of the cytokine from IL-1 family in endometrium-related disorders, particularly in endometriosis. METHODS: The information about the impact of cytokine from IL-1 cytokine family on the pathogenesis and development of endometriosis was obtained with an electronic literature search based on the PubMed and Medline databases, spanning the period of January 1950 to July 2017 and includes associated references in the published studies...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29330559/a-post-translational-balancing-act-the-good-and-the-bad-of-sumoylation-in-pancreatic-islets
#6
EDITORIAL
Patrick E MacDonald
Post-translational modification of proteins contributes to the control of cell function and survival. The balance of these in insulin-producing pancreatic beta cells is important for the maintenance of glucose homeostasis. Protection from the damaging effects of reactive oxygen species is required for beta cell survival, but if this happens at the expense of insulin secretory function then the ability of islets to respond to changing metabolic conditions may be compromised. In this issue of Diabetologia, He et al ( https://doi...
January 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29329414/is-big-bad-or-bearable-long-term-renal-transplant-outcomes-in-obese-recipients
#7
O M McCloskey, A E Courtney, J A McCaughan, P Devine
No abstract text is available yet for this article.
January 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29327925/writing-theory-and-modeling-papers-for-langmuir-the-good-the-bad-and-the-ugly
#8
David S Sholl, Zuihof Han, Shu-Hong Yu
Langmuir has a long tradition of publishing excellent theory and modeling papers. As of the time of writing, for example, two modeling papers from 2013 are among the most cited 10 papers in Langmuir from that year [1,2] and the most cited paper from Langmuir in 2016 is a theory and modeling paper [3]. At the same time, many manuscripts using theory and modeling are submitted to Langmuir but are ultimately rejected. Although Langmuir has a mandate to publish the highest quality work of all kinds relevant to interface science, there are some issues that exist that are specific to considering work based on theory and modeling...
January 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29325852/quality-and-readability-of-internet-based-information-on-halitosis
#9
Jung Hwan Jo, Eui Joo Kim, Ji Rak Kim, Moon Jong Kim, Jin Woo Chung, Ji Woon Park
OBJECTIVE: To evaluate quality and readability of Internet-based information on halitosis. STUDY DESIGN: An Internet search through 3 engines (Google, Yahoo, and Bing) was done with the terms ("bad breath," "halitosis," "oral malodor," "foul breath," "mouth malodor," "breath malodor," "fetor ex ore," "fetor oris," "ozostomia," and "stomatodysodia"). The first 50 websites from each engine resulting from each search term were screened. Included websites were evaluated using Health on the Net (HON) criteria, Journal of American Medical Association (JAMA) benchmarks, DISCERN, Ensuring Quality Information for Patients (EQIP), Flesch Reading Ease (FRE) score, and Flesch-Kincaid Grade level...
December 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29325354/-excision-of-giant-desmoid-in-the-abdominal-wall-method-of-abdominal-wall-reconstruction-and-follow-up-of-long-termed-effect
#10
Y Fei, J Y Li
Objective: To explore the ideal procedure of excision and repair for giant desmoid in the abdominal wall and long-termed follow-up results. Methods: Clinical and follow-up data of 24 patients with giant desmoid in the abdominal wall underwent radical removal and immediate abdominal wall reconstruction in Diagnostic and Therapeutic Center of Hernia and Abdominal Wall Diseases, First Affiliated Hospital of People's Liberation Army General Hospital from October 2006 to October 2016 were analyzed retrospectively...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29324224/good-bug-bad-bug-breaking-through-microbial-stereotypes
#11
Mihai Cirstea, Nina Radisavljevic, B Brett Finlay
Our expanding knowledge of microbial mechanisms is challenging the notion of "good" versus "bad" microbes and encouraging a better understanding of their roles in various contexts before their widespread therapeutic and clinical application. The intestinal microbe Akkermansia muciniphila, a promising probiotic with an emerging cautionary tale, best highlights this challenge.
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29319545/patient-reported-outcomes-after-lateral-wall-sinus-floor-elevation-a-systematic-review
#12
Faris Younes, Aryan Eghbali, Thomas Goemaere, Thomas De Bruyckere, Jan Cosyn
OBJECTIVES: The aim of this systematic review is to assess patient-reported outcome measures (PROMs) after a sinus lift elevation by means of a lateral approach. MATERIAL AND METHODS: An electronic search was performed to search for eligible publications reporting PROMs after a lateral wall sinus lift procedure. Selected articles were further scrutinized and underwent a quality check before inclusion in a final study pool. RESULTS: The electronic search provided us with 2444 articles of which 98 were further examined through a full-text analysis...
January 9, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29319135/radiosynoviorthesis-of-acromioclavicular-joint-using-169er-citrate-prospective-evaluation-of-efficacy
#13
Marika Vereb, Knut Liepe, Manfred Fischer, Lucia Kaliska, Lucia Noskovicova, Sona Balogova
BACKGROUND: There is a clinical need for therapeutic alternative in patients with persisting painful arthritis of AC-joint and failure of previous treatments. However, no radiopharmaceutical is currently explicitly approved for radiosynoviorthesis of acromioclavicular joint. The aim of our study was to prospectively assess the efficacy and safety of radiosynoviorthesis of acromioclavicular joint using erbium-169 citrate. MATERIAL AND METHODS: Radiosynoviorthesis of acromioclavicular joint was performed in 51 consecutive patients (18 males, 33 females) mean age 64...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29318903/decoding-oral-cancer-conundrums-from-bad-luck-point-of-view
#14
Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
No abstract text is available yet for this article.
January 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29318214/urinary-calcium-excretion-and-risk-of%C3%A2-chronic-kidney-disease-in-the-general%C3%A2-population
#15
Jacob M Taylor, Lyanne M Kieneker, Martin H de Borst, Sipke T Visser, Ido P Kema, Stephan J L Bakker, Ron T Gansevoort
Introduction: High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronic kidney disease (CKD) in community-dwelling subjects. Methods: Urine samples of 5491 subjects who were free of CKD at baseline and participated in the Prevention of Renal and Vascular End-Stage Disease study (a prospective, observational, general population-based cohort of Dutch men and women aged 28-75 years) were examined for UCaE...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29315131/the-big-bad-obesity-pandemic
#16
Quentin R Regestein
No abstract text is available yet for this article.
January 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29313888/british-association-of-dermatologists-guidelines-for-the-management-of-lichen-sclerosus-2018
#17
F M Lewis, F M Tatnall, S S Velangi, C B Bunker, A Kumar, F Brackenbury, M F Mohd Mustapa, L S Exton
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of lichen sclerosus (LS) in adults (18+ years), children (0-12 years) and young people (13-17 years). The document aims to. offer an appraisal of all relevant literature up to July 2017, focusing on any key developments. address important, practical clinical questions relating to the primary guideline objective. provide guideline recommendations and if appropriate research recommendations. The guideline is presented as a detailed review with highlighted recommendations for practical use in primary care and in secondary care clinics, in addition to an updated Patient Information Leaflet (PIL; available on the BAD website, http://www...
January 4, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29313529/bad-germs-are-trapped
#18
Liman Zhang, Hao Wu
Activation of the NAIP/NLRC4 inflammasomes initiates inflammatory responses against bacterial invasion. Two recent reports described the cryo-EM structure of the flagellin/NAIP5 complex, providing important insights into the mechanism of bacterial sensing by innate immunity.
January 9, 2018: Cell Research
https://www.readbyqxmd.com/read/29313423/rho-guanosine-nucleotide-exchange-factors-are-not-such-bad-guys-after-all-in-cancera
#19
Javier Robles-Valero, L Francisco Lorenzo-Martín, Isabel Fernández-Pisonero, Xosé R Bustelo
Rho GDP/GTP exchange factors (GEFs), the enzymes that trigger the stimulation of Rho GTPases during cell signaling, are widely deemed as potential therapeutic targets owing to their protumorigenic functions. However, the sparse use of animal models has precluded a full understanding of their pathophysiological roles at the organismal level. In a recent article in Cancer Cell, we have reported that the Vav1 GEF unexpectedly acts as a tumor suppressor by mediating the noncatalytic nucleation of cytoplasmic complexes between the E3 ubiquitin ligase Cbl-b and the active Notch1 intracellular domain (ICN1)...
January 9, 2018: Small GTPases
https://www.readbyqxmd.com/read/29312620/copy-number-variations-in-atypical-fibroxanthomas-and-pleomorphic-dermal-sarcomas
#20
Doris Helbig, Alexander Quaas, Cornelia Mauch, Sabine Merkelbach-Bruse, Reinhard Büttner, Michael Emberger, Marion Wobser, Vanessa Rüsseler, Katharina Pütz, Elke Binot, Jan Rehker, Jan Budczies, Michaela Angelika Ihle
Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are frequent cutaneous sarcomas typically arising on sun-exposed skin in elderly patients. In contrast to AFX, which generally do not recur after complete excision, PDS locally recur in up to 50% and metastasize in up to 20%. We recently detected characteristic UV-induced TP53 mutations as potential driver mutation in almost all PDS investigated as well as activating PIK3CA and RAS gene mutations in around one third of our tumors representing targets for personalized treatments in patients with unresectable or metastasized PDS...
December 12, 2017: Oncotarget
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