Patricio Millar Vernetti, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Italo Biaggioni, Cyndya A Shibao, Amanda Peltier, Roy Freeman, Christopher Gibbons, David S Goldstein, Phillip A Low, Wolfgang Singer, Elizabeth A Coon, Mitchell G Miglis, Gregor K Wenning, Alessandra Fanciulli, Steven Vernino, Rebecca A Betensky, Horacio Kaufmann
We aimed to describe the clinical features of patients with pure autonomic failure (PAF) preceding phenoconversion that could be useful as predictive markers for advancing α-synuclein-associated neurodegeneration of the brain. Patients diagnosed with PAF were evaluated at 8 Centers (7-US based and 1 European) and enrolled in a longitudinal observational cohort study (NCT01799915). Subjects underwent detailed assessments of motor, sleep, olfactory, cognitive, and autonomic function and were followed prospectively to determine whether they developed parkinsonism or dementia for up to 10 years...
February 15, 2024: Brain