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Ropinirole and stroke

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https://www.readbyqxmd.com/read/25483226/serotonin-syndrome-in-stroke-patients
#1
Sung Ho Jang, Yong Min Kwon, Min Cheol Chang
OBJECTIVE: Serotonin syndrome is a potentially life-threatening condition that can be caused by administration of agents that increase serotonergic activity in the brain. We report here on 2 stroke patients who presented with serotonin syndrome following administration of dopaminergic agents. CASE REPORT: Two stroke patients were administered ropinirole (patient 1) and carbidopa/levodopa (patient 2) during rehabilitation. Both patients exhibited the clinical features of serotonin syndrome, coinciding with an increase in dosage of each drug...
March 2015: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/25070961/predictors-and-biomarkers-of-treatment-gains-in-a-clinical-stroke-trial-targeting-the-lower-extremity
#2
RANDOMIZED CONTROLLED TRIAL
Erin Burke, Bruce H Dobkin, Elizabeth A Noser, Lori A Enney, Steven C Cramer
BACKGROUND AND PURPOSE: Behavioral measures are often used to distinguish subgroups of patients with stroke (eg, to predict treatment gains, stratify clinical trial enrollees, or select rehabilitation therapy). In studies of the upper extremity, measures of brain function using functional magnetic resonance imaging (fMRI) have also been found useful, but this approach has not been examined for the lower extremity. The current study hypothesized that an fMRI-based measure of cortical function would significantly improve prediction of treatment-induced lower extremity behavioral gains...
August 2014: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/20378354/successful-treatment-of-post-stroke-apathy-by-the-dopamine-receptor-agonist-ropinirole
#3
Naoto Kohno, Satoshi Abe, Genya Toyoda, Hiroaki Oguro, Hirokazu Bokura, Shuhei Yamaguchi
Dopamine D2/3 receptor agonists have been widely used to treat motor symptoms in Parkinson's disease and are also reported to improve cognitive and emotional disturbances. Here we describe a patient who developed severe apathy after cerebral infarction in the prefrontal cortex. After administration of ropinirole, his verbal output and spontaneity in daily life was improved remarkably. This improvement was associated with increased blood flow in the prefrontal cortex and basal ganglia. We suggest that ropinirole may be a treatment option for deficits in motivated behavior after prefrontal damage...
June 2010: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/19520987/randomized-placebo-controlled-double-blind-study-of-ropinirole-in-chronic-stroke
#4
RANDOMIZED CONTROLLED TRIAL
Steven C Cramer, Bruce H Dobkin, Elizabeth A Noser, Rachelle W Rodriguez, Lori A Enney
BACKGROUND AND PURPOSE: Evidence suggests the potential to improve motor status in patients with stroke by modifying brain catecholaminergic tone. The current study hypothesized that increased dopaminergic tone via the dopamine agonist ropinirole, when combined with physiotherapy (PT), would significantly and safely increase gait velocity. METHODS: Patients with moderate motor deficits due to stroke 1 to 12 months prior were randomized (double blinded) to 9 weeks of immediate-release ropinirole or placebo, each with PT, and followed up for 3 additional weeks...
September 2009: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/1969802/autonomic-and-haemodynamic-responses-to-sk-f-101468-ropinirole-a-da2-agonist-in-anaesthetised-cats
#5
R J Eden, M S Wallduck, B Patel, D A Owen
The haemodynamic and autonomic nervous system effects of the DA2 agonist, SK & F 101468, have been studied in anaesthetised cats. SK & F 101468 inhibited the tachycardia response to cardiac accelerans nerve stimulation. The inhibition, reversed by L-sulpiride a selective DA2 receptor antagonist, was dose-dependent over the dose range 10-50 micrograms.kg-1 and there was proportionally greater inhibition of the responses to low rather than high frequency stimulation. There was evidence that SK & F 101468-A inhibited sympathetically mediated reflexes, but even at high doses, of up to 500 micrograms...
January 17, 1990: European Journal of Pharmacology
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