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Stuart Biddle
In the JAPA supplement (JAPA 24[Suppl.], June 2016), which contained the abstracts for the 9th World Congress on Active Ageing, an incorrect abstract appears on page S102. This abstract, "An Australian Unique Way of Addressing the Research-Selling Health and Wellness to the Over 60s with Active Life Weekends", by B. Lord, was a duplicate of an earlier printed abstract. The correct abstract appears below. We apologize for this error. The online version has been corrected.
July 2016: Journal of Aging and Physical Activity
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Journal of the American Psychoanalytic Association
Jiang-Jiang Qin, Wei Wang, Sushanta Sarkar, Sukesh Voruganti, Rajesh Agarwal, Ruiwen Zhang
The transcription factor NFAT1 and the oncogene MDM2 have crucial roles in breast cancer development, progression, and metastasis. We have recently discovered that NFAT1 activates MDM2 expression. Here, we identified a small molecule (named Inulanolide A) that dually inhibited both NFAT1 and MDM2 in breast cancer cells in vitro and in vivo. Unlike conventional MDM2 inhibitors, Inulanolide A (InuA) exerted its selective anticancer activity in both p53-dependent and -independent manners. InuA decreased cell proliferation and induced G2/M phase arrest and apoptosis in breast cancer cells; it also led to a decrease in MDM2, NFAT1 and proteins associated with cell proliferation, and an increase in apoptotic signal related proteins...
May 31, 2016: Oncotarget
Deva Japa, Mahpaekar Mashhadi, Sanjeeth Peter
Atrial myxomas are the commonest benign primary tumours of the heart. They are generally 2 to 6 cm in size. Depending on their size and site may result in mitral valve obstruction which may lead to pulmonary hypertension. Clinical symptoms may suggest the presence of a myxoma but echocardiography is the mainstay of diagnosis and confirmation is by histopathology. A well-formed, organized thrombus is a common differential. The report of an unusually large left atrial myxoma that occurred in a 54-year-old male causing mitral valve obstruction and pulmonary hypertension is presented here...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Jiang-Jiang Qin, Wei Wang, Sukesh Voruganti, Hui Wang, Wei-Dong Zhang, Ruiwen Zhang
Transcription factor NFAT1 has been recently identified as a new regulator of the MDM2 oncogene. Targeting the NFAT1-MDM2 pathway represents a novel approach to cancer therapy. We have recently identified a natural product MDM2 inhibitor, termed JapA. As a specific and potent MDM2 inhibitor, JapA inhibits MDM2 at transcriptional and post-translational levels. However, the molecular mechanism remains to be fully elucidated for its inhibitory effects on MDM2 transcription. Herein, we reported that JapA inhibited NFAT1 and NFAT1-mediated MDM2 transcription, which contributed to the anticancer activity of JapA...
October 20, 2015: Oncotarget
Hillary Z Kimbrell, Andrew B Sholl, Swarnamala Ratnayaka, Shanker Japa, Michelle Lacey, Gandahari Carpio, Parisha Bhatia, Emad Kandil
BACKGROUND: BRAF V600E mutation is associated with poor prognosis in patients with papillary thyroid carcinoma (PTC). PTC is often multifocal, and there are no guidelines on how many tumors to test for BRAF mutation in multifocal PTC. METHODS: Fifty-seven separate formalin-fixed and paraffin-embedded PTCs from twenty-seven patients were manually macrodissected and tested for BRAF mutation using a commercial allele-specific real-time polymerase chain reaction-based assay (Entrogen, Woodland Hills, CA)...
2015: BioMed Research International
(no author information available yet)
No abstract text is available yet for this article.
June 2015: Journal of the American Psychoanalytic Association
Ornampai Japa, Jane E Hodgkinson, Richard D Emes, Robin J Flynn
The helminth Fasciola hepatica causes fasciolosis throughout the world, a major disease of livestock and an emerging zoonotic disease in humans. Sustainable control mechanisms such as vaccination are urgently required. To discover potential vaccine targets we undertook a genome screen to identify members of the transforming growth factor (TGF) family of proteins. Herein we describe the discovery of three ligands belonging to this superfamily and the cloning and characterisation of an activin/TGF like molecule we term FhTLM...
2015: Veterinary Research
(no author information available yet)
No abstract text is available yet for this article.
February 2015: Journal of the American Psychoanalytic Association
Claudio Japas, Synnøve Knutsen, Salem Dehom, Hildemar Dos Santos, Serena Tonstad
BACKGROUND: Obesity increases risk of premature disease, and may be associated with unfavorable lifestyle changes that add to risk. This study analyzed the association of midlife BMI change with current lifestyle patterns among multiethnic men. METHODS: Men aged 40-60 years (n=9864) retrospectively reported body weight between ages 20-40 years and current dietary, TV, physical activity and sleep practices in the Adventist Health Study II, a study of church-goers in the US and Canada...
November 2014: Obesity Research & Clinical Practice
(no author information available yet)
No abstract text is available yet for this article.
June 27, 2014: Journal of the American Psychoanalytic Association
Mercedes Perullini, Matías Jobbágy, María Laura Japas, Sara A Bilmes
The fine tuning of porosity in sol gel based devices makes possible the design of novel applications in which the transport of molecules through the oxide gel plays a crucial role. In this work we develop a new method for the simultaneous analysis of diffusion and adsorption of small diffusing probes, as anionic and cationic dyes, through silica mesoporous hydrogels synthesized by sol-gel. The novelty of the work resides in the simplicity of acquisition of the experimental data (by means of a desk scanner) and further mathematical modeling, which is in line with high throughput screening procedures, enabling rapid and simultaneous determination of relevant diffusion and adsorption parameters...
July 1, 2014: Journal of Colloid and Interface Science
Yan Yan, Yue Wu, Jun Guo, Ke-Cheng Tian, Ding-Ming Wang
To study the genotype of Norovirus associated with acute gastroenteritis in Guizhou Province 2011, the patients' fecal specimens were collected from the Guizhou Province People's Hospital in the period of May to December 2011. Noroviruses in specimens were detected by a real-time reverse transcription polymerase chain reaction (Real-time RT-PCR). VP1 genes of norovirus-positive strains were then cloned and sequenced. Out of 70 clinical samples, the positive rates for norovirus G I (1 strain) and G II (34 strains) were 1...
January 2013: Bing du Xue Bao, Chinese Journal of Virology
Kevin F Erickson, Sohan Japa, Douglas K Owens, Glenn M Chertow, Alan M Garber, Jeremy D Goldhaber-Fiebert
OBJECTIVES: The authors sought to evaluate the cost-effectiveness of statins for primary prevention of myocardial infarction (MI) and stroke in patients with chronic kidney disease (CKD). BACKGROUND: Patients with CKD have an elevated risk of MI and stroke. Although HMG Co-A reductase inhibitors (“statins”) may prevent cardiovascular events in patients with non–dialysis-requiring CKD, adverse drug effects and competing risks could materially influence net effects and clinical decision-making...
March 26, 2013: Journal of the American College of Cardiology
Rodney E Shackelford, Nicholas A Whitling, Patricia McNab, Shanker Japa, Domenico Coppola
Activating point mutations in codons 12, 13, and 61 of the KRAS proto-oncogene are common in colorectal, non-small cell lung, pancreatic, and thyroid cancers. Constitutively activated KRAS mutations are strongly associated with a resistance to anti-epidermal growth factor receptor (EGFR) therapies, such as panitumumab and cetuximab used for treating metastatic colorectal carcinoma and EGFR tyrosine inhibitors used for advanced non-small cell lung cancers. Since anti-EGFR therapies are costly and may exert deleterious effects on individuals without activating mutations, KRAS mutation testing is recommended prior to the initiation of anti-EGFR therapy for these malignancies...
July 2012: Genes & Cancer
Diane E Whaley
No abstract text is available yet for this article.
July 2012: Journal of Aging and Physical Activity
Elizabeth A Danze, Stephen M Sonnenberg
In this discussion of Adele Tutter's "Design as Dream and Self-Representation: Philip Johnson and the Glass House of Atreus" (JAPA 59/3), the architect Elizabeth Danze and the psychoanalyst Stephen Sonnenberg highlight what they see as the most important of Tutter's contributions as regards an understanding of Johnson's work. They then discuss those contributions as they illuminate the study of the relationship of architecture and design, on the one hand, and psychoanalysis on the other.
June 2012: Journal of the American Psychoanalytic Association
Jennifer Stuart
Analytic work with a pregnant woman may foster the psychological gestation of the self-as-mother. For the mother--as for the infant--the developmental process continues well beyond delivery. It should not surprise us, then, that many mothers continue to bring their babies to sessions after birth. Analytic work in this context can affect a patient's sense of herself, and perhaps her competence, as a mother. Yet the presence of babies in the consulting room is an underacknowledged feature of contemporary practice...
June 2012: Journal of the American Psychoanalytic Association
Steven T Levy
No abstract text is available yet for this article.
December 2011: Journal of the American Psychoanalytic Association
Sabrina Simoncelli, Pablo A Hoijemberg, M Laura Japas, Pedro F Aramendía
The proton transfer from 2-naphthol to aliphatic amines was studied in supercritical CO(2) (scCO(2)) and in cyclohexane as reference solvent, by absorption and fluorescence spectroscopy and by time-resolved emission. Irradiation of 2-naphthol in scCO(2) in the presence of ethyldiisopropylamine shows dynamic fluorescence quenching of the acidic form of 2-naphthol and emission from the basic form. Fluorescence excitation spectra show that the emission of the basic form is originated upon excitation of the acidic form...
December 22, 2011: Journal of Physical Chemistry. A
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