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Rosana C Gomes, Elaine C O Guirro, Adriana C Gonçalves, Jayme A Farina Junior, Luiz O Murta Junior, Rinaldo R J Guirro
INTRODUCTION: Severe burns benefit from skin grafting, and grafting surgery is of great importance in the treatment of these injuries. As a result, there is formation of an additional wound at the donor site, which is painful and susceptible to infection. However, the therapeutic approach to these problems at donor sites for skin grafting is insufficiently explored in the literature. AIM: To evaluate electrical stimulation of the donor sites of burn patients treated by grafting surgery...
February 2, 2018: Burns: Journal of the International Society for Burn Injuries
Mirela Pelizaro Valeri, Guilherme Borges Dias, Valéria do Socorro Pereira, Gustavo Campos Silva Kuhn, Marta Svartman
Satellite DNAs (satDNAs) are major components of eukaryote genomes. However, because of their quick divergence, the evolutionary origin of a given satDNA family can rarely be determined. Herein we took advantage of available primate sequenced genomes to determine the origin of the CapA satDNA (approx. 1500 bp long monomers), first described in the tufted capuchin monkey Sapajus apella We show that CapA is an abundant satDNA in Platyrrhini, whereas in the genomes of most eutherian mammals, including humans, this sequence is present only as a single copy located within a large intron of the NOS1AP (nitric oxide synthase 1 adaptor protein) gene...
January 2018: Biology Letters
N Capa, C Celebi, A Casur, I Tuncel, A Usumez
PURPOSE: The purpose of this study was to evaluate the effect of the different color of resin cements and zirconia cores on the translucency parameter (TP) of the restoration that simulates the implant-supported fixed prosthesis using titanium base on the bottom. MATERIALS AND METHODS: Zirconia core plates (Zr-Zahn) were prepared in A2 shades (n = 11). Resin cement plates (3M ESPE) were prepared in A2, A1, translucent (TR) shades (n = 11). The initial color measurements and were measured on zirconia core plates, and resin cements plates using a spectrophotometer...
December 2017: Nigerian Journal of Clinical Practice
Sharon Clark, Debbie Emberly, Kathleen Pajer, Emily Delong, Susan McWilliam, Alexa Bagnell, Sabina Abidi, Barbara Casey, William Gardner
Objective: The Choice and Partnership Approach (CAPA) is designed to improve access and quality of pediatric mental health care. We tested whether CAPA improved access in an academic pediatric hospital. Method: We used de-identified administrative data to compare access pre- (2011) and post-CAPA (2013). Results: Wait time to first appointment in 2011 was 225.3 days (95% CI = [211.0, 239.6], N = 364), compared to 93.0 days (95% CI = [89.2, 96...
January 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
Ying Huang, Xiaodong Liu, Zheng Cui, Daniel Wiegmann, Giuliana Niro, Christian Ducho, Yuan Song, Zhaoyong Yang, Steven G Van Lanen
Capuramycins are antimycobacterial antibiotics that consist of a modified nucleoside named uridine-5'-carboxamide (CarU). Previous biochemical studies have revealed that CarU is derived from UMP, which is first converted to uridine-5'-aldehyde in a reaction catalyzed by the dioxygenase CapA and subsequently to 5'-C-glycyluridine (GlyU), an unusual β-hydroxy-α-amino acid, in a reaction catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent transaldolase CapH. The remaining steps that are necessary to furnish CarU include decarboxylation, O atom insertion, and oxidation...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
Júlia Dauernheimer Machado, Eduardo Guimarães Camargo, Roberta Boff, Laís da Silva Rodrigues, Joíza Lins Camargo, Ariana Aguiar Soares, Sandra Pinho Silveiro
AIM: To evaluate the accuracy of creatinine and cystatin C (cysC) equations to estimate glomerular filtration rate (GFR) in type 2 diabetes mellitus (DM) patients and healthy adults. METHODS: Case-control study including 84 patients with type 2 DM and 100 healthy adults with measured GFR (mGFR)≥60mL/min/1.73m2. GFR was measured by 51Cr-EDTA and estimated (eGFR) by the following equations using creatinine, cysC or both markers: Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Caucasian Asian Pediatrics and Adults (CAPA), CKD-EPI creatinine-cystatin C (CKDEPI-CC), and CKD-EPI cystatin C (CKDEPIcysC)...
January 10, 2018: Clinical Biochemistry
Fatih Artvinli, Şahap Erkoç, Fulya Kardeş
Introduction: The aim of this article is to provide a brief history of Turkish Neuropsychiatric Society by examining its institutional background, the milestones within its history, and the major activities undertaken by the organization during the years. Methods: Firstly, the books, journals, and articles that are related to the history of psychiatry and neurology in Turkey have been reviewed and the information that can explain the history of the society has been brought together...
December 2017: Noro Psikiyatri Arsivi
Joffre V Tandazo-Yunga, Mario X Ruiz-González, Jacqueline R Rojas, Edwin D Capa-Mora, Jaime Prohens, José D Alejandro, Pablo G Acosta-Quezada
Changing climatic conditions impose a challenge both to biodiversity and food security. The effects of climate change affect different aspects of the plant or crop, such as morphological and phenological aspects, as well as yield. The effects of greenhouse conditions might be comparable in some cases to a permanent extreme disturbance in climate and weather, thus, contributing to our knowledge on climate change impacts on plant species. We have investigated the differences for 23 traits in two cultivar groups of an Andean traditional crop, Solanum betaceum, under two different environmental conditions that correspond to the traditional practices in the open field and three cultural managements under greenhouse conditions (no fertilization or control, organic, and mineral)...
2017: PloS One
Elena Kosobrodova, Alexey Kondyurin, Wojciech Chrzanowski, Christina Theodoropoulos, Elena Morganti, Dietmar Hutmacher, Marcela M M Bilek
Polycaprolactone with five different molecular weights was spin-coated on silicon wafers and plasma immersion ion implanted (PIII) with ion fluence in the range 5 × 1014-2 × 1016 ions/cm2. The effects of PIII treatment on the optical properties, chemical structure, crystallinity, morphology, gel fraction formation and wettability were investigated. As in the case of a number of previously studied polymers, oxidation and hydrophobic recovery of the PIII treated PCL follow second order kinetics. CAPA 6250, which has the lowest molecular weight and the highest degree of crystallinity of the untreated PCL films studied, has the highest carbonization of the modified layer after PIII treatment...
December 14, 2017: Journal of Materials Science. Materials in Medicine
Anshu Gupta, Tanima Dwivedi, Sadhana, Raju Chaudhary
Introduction: Patient's satisfaction is the need of the hour and one of the most important quality indicators in the laboratory medicine. Aim: To assess the patient's satisfaction with phlebotomy services in a neuropsychiatric hospital by a structured questionnaire with grading scale. Also, identify the problems causing dissatisfactions and to undertake necessary Corrective and Preventative Action (CAPA). Materials and Methods: Total 1200 patients were randomly selected over a period of two months (June and July 2016)...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Behide Saltepe, Ebru Sahin Kehribar, Side Selin Su Yirmibesoglu, Urartu Ozgur Safak Seker
: An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic circuits have been imple-mented such as engineered logic operation in analog and digital circuits. Whole cell biosensors are widely used biological devices that employ several biocomputation tools to program cells for desired functions. Up to date, a wide range of whole-cell biosensors have been designed and implemented for disease theranostics, biomedical applications and environmental monitoring...
November 23, 2017: ACS Sensors
Anthony Vacher, Sana El Mhamdi, Alain dʼHollander, Marion Izotte, Yves Auroy, Philippe Michel, Jean-Luc Quenon
OBJECTIVE: The aim of the study was to assess the effectiveness of a new methodological tool for the identification of corrective and preventive actions (CAPAs) after root cause analysis of health care-related adverse events. METHODS: From January to June 2010, we conducted a randomized controlled trial involving risk managers from 111 health care facilities of the Aquitaine Regional Center for Quality and Safety in Health Care (France). Fifty-six risk managers, randomly assigned to two groups (intervention and control), identified CAPAs in response to two sequentially presented adverse event scenarios...
November 8, 2017: Journal of Patient Safety
Jonas Björk, Anders Grubb, Vilmundur Gudnason, Olafur S Indridason, Andrew S Levey, Runolfur Palsson, Ulf Nyman
Background: Validation studies comparing glomerular filtration rate (GFR) equations based on standardized creatinine and cystatin C assays in the elderly are needed. The Icelandic Age, Gene/Environment Susceptibility-Kidney cohort was used to compare two pairs of recently developed GFR equations, the revised Lund-Malmö creatinine equation (LMRCr) and the arithmetic mean of the LMRCr and Caucasian, Asian, Paediatric and Adult cystatin C equations (MEANLMR+CAPA), as well as the Full Age Spectrum creatinine equation (FASCr) and its combination with cystatin C (FASCr+Cys), with the corresponding pair of Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPICr and CKD-EPICr+Cys)...
October 5, 2017: Nephrology, Dialysis, Transplantation
Jonas Björk, Sten Erik Bäck, Natalie Ebert, Marie Evans, Anders Grubb, Magnus Hansson, Ian Jones, Edmund J Lamb, Peter Martus, Elke Schaeffner, Per Sjöström, Ulf Nyman
BACKGROUND: Although recommended by the Kidney Disease Improving Global Outcomes, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPICR) creatinine equation was not targeted to estimate glomerular filtration rate (eGFR) among older adults. The Berlin Initiative Study (BIS1CR) equation was specifically developed in older adults, and the Lund-Malmö revised (LMRCR) and the Full Age Spectrum (FASCR) equations have shown promising results in older adults. Our aim was to validate these four creatinine equations, including addition of cystatin C in a large multicenter cohort of Europeans ≥70 years...
October 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
Miguel Ángel Martínez-García, Erica Riveiro-Falkenbach, José L Rodríguez-Peralto, Eduardo Nagore, Antonio Martorell-Calatayud, Francisco Campos-Rodríguez, Ramón Farré, Luis Hernández Blasco, Jose Bañuls Roca, Eusebi Chiner Vives, Alicia Sánchez-de-la-Torre, Jorge Abad Capa, Josep Maria Montserrat, Isaac Almendros, Amalia Pérez-Gil, Valentin Cabriada Nuño, Irene Cano-Pumarega, Jaime Corral Peñafiel, Trinidad Diaz Cambriles, Olga Mediano, Joan Dalmau Arias, David Gozal
Melanoma is a highly prevalent cancer that is associated with substantial mortality. Although clinical staging procedures can serve as relatively robust prognostic indicators, we aimed to determine whether assessments of the abundance of hypoxia inducible factor-1α (HIF-1α) or vascular endothelial growth factor (VEGF) in postexcisional melanoma tumor tissues may enable more accurate determination of tumor aggressiveness. We carried out a multicenter prospective study, in which we systematically evaluated 376 consecutive patients diagnosed with melanoma, and performed histochemical assessments for both HIF-1α and VEGF immunoreactivity in the tumor biopsies...
December 2017: Melanoma Research
Susanne Neupert, Pawel Marciniak, Rene Köhler, Ronald J Nachman, Charles P-C Suh, Reinhard Predel
Capa and pyrokinin (pk) genes in hexapods share a common evolutionary origin. Using transcriptomics and peptidomics, we analyzed products of these genes in two beetles, the giant mealworm beetle (Zophobas atratus; Tenebrionidae) and the boll weevil (Anthonomus grandis grandis; Curculionidae). Our data revealed that even within Coleoptera, which represents a very well-defined group of insects, highly different evolutionary developments occurred in the neuropeptidergic system. These differences, however, primarily affect the general structure of the precursors and differential processing of mature peptides and, to a lesser degree, the sequences of the active core motifs...
August 31, 2017: General and Comparative Endocrinology
Robert M Gordon, Jing Lan
How effective is psychoanalytic/psychodynamic distance training over the Internet? To assess this, we surveyed graduates of the 2-year and 4-year programs of the China America Psychoanalytic Alliance (CAPA). The main results of the 90 graduates' surveys showed that 77% of their work involves a psychoanalytic formulation of their cases as compared to other theoretical orientations. Graduates highly rated the effectiveness of their own psychoanalytic therapy over videoconferencing (VCON). Graduates' ratings of treatment with their patients over VCON positively correlated with years of psychoanalytic education, number of days a week in own treatment, years doing psychoanalytic treatment, and degree working with a psychoanalytic orientation...
2017: Psychodynamic Psychiatry
Debra Topham, Debra Drew
CAPA is a multifaceted pain assessment tool that was adopted at a large tertiary Midwest hospital to replace the numeric scale for adult patients who could self-report their pain experience. This article describes the process of implementation and the effect on patient satisfaction scores. Use of the tool is supported by the premise that pain assessment entails more than just pain intensity and that assessment is an exchange of meaning between patients and clinicians dependent on internal and external factors...
August 23, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
Zhangfei Shen, Yu Chen, Lingjuan Hong, Zhenteng Cui, Huipeng Yang, Xiaobai He, Ying Shi, Liangen Shi, Feng Han, Naiming Zhou
CAPA peptides, such as periviscerokinin (PVK), are insect neuropeptides involved in many signaling pathways controlling, for example, metabolism, behavior, and reproduction. They are present in a large number of insects and, together with their cognate receptors, are important for research into approaches for improving insect control. However, the CAPA receptors in the silkworm (Bombyx mori) insect model are unknown. Here, we cloned cDNAs of two putative CAPA peptide receptor genes, BNGR-A27 and -A25, from the brain of B...
October 6, 2017: Journal of Biological Chemistry
Selim Terhzaz, Lucy Alford, Joseph Gc Yeoh, Richard Marley, Anthony J Dornan, Julian At Dow, Shireen A Davies
BACKGROUND: Neuropeptides are central to the regulation of physiological and behavioural processes in insects, directly impacting cold and desiccation survival. However, little is known about the control mechanisms governing these responses in Drosophila suzukii. The close phylogenetic relationship of D. suzukii with Drosophila melanogaster allows, through genomic and functional studies, an insight into the mechanisms directing stress tolerance in D. suzukii. RESULTS: Capability (Capa), leucokinin (LK), diuretic hormone 44 (DH44 ) and DH31 neuropeptides demonstrated a high level of conservation between D...
July 17, 2017: Pest Management Science
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