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https://www.readbyqxmd.com/read/28812768/chemical-nutritive-composition-and-a-wide-range-of-bioactive-properties-of-honey-mushroom-armillaria-mellea-vahl-fr-kummer
#1
Marina Kostić, Marija Smiljković, Jovana Petrović, Jasmina Glamočlija, Lillian Barros, Isabel C F R Ferreira, Ana Ćirić, Marina Soković
A. mellea fruiting bodies collected from nature were chemically characterized and shown to be rich in carbohydrates (81.25 g per 100 g dw), ash, fat and proteins (8.84 g per 100 g dw, 1.97 g per 100 g dw and 1.81 g per 100 g dw, respectively). Mannitol was the main free sugar while malic acid was the most abundant organic acid. δ-Tocopherol was the dominant form of tocopherols with 42.41 μg per 100 g dw. Polyunsaturated fatty acids were predominant, followed by saturated and monounsaturated fatty acids. A methanolic extract prepared from these samples was tested for antioxidant, quorum sensing and antimicrobial assays, as well as for its cytotoxicity effects...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28809501/microencapsulated-solid-lipid-nanoparticles-as-a-hybrid-platform-for-pulmonary-antibiotic-delivery
#2
Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices...
August 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28803402/actin-filaments-regulate-the-adhesion-between-the-plasma-membrane-and-the-cell-wall-of-tobacco-guard-cells
#3
Qin Yu, Jing-Jing Ren, Lan-Jing Kong, Xiu-Ling Wang
During the opening and closing of stomata, guard cells undergo rapid and reversible changes in their volume and shape, which affects the adhesion of the plasma membrane (PM) to the cell wall (CW). The dynamics of actin filaments in guard cells are involved in stomatal movement by regulating structural changes and intracellular signaling. However, it is unclear whether actin dynamics regulate the adhesion of the PM to the CW. In this study, we investigated the relationship between actin dynamics and PM-CW adhesion by the hyperosmotic-induced plasmolysis of tobacco guard cells...
August 13, 2017: Protoplasma
https://www.readbyqxmd.com/read/28801787/reduction-of-68-ga-psma-renal-uptake-with-mannitol-infusion-preliminary-results
#4
Federica Matteucci, Emilio Mezzenga, Paola Caroli, Valentina Di Iorio, Anna Sarnelli, Monica Celli, Lorenzo Fantini, Andrea Moretti, Riccardo Galassi, Ugo De Giorgi, Giovanni Paganelli
PURPOSE: Urea-based prostate-specific membrane antigen (PSMA) ligands labelled with (68)Ga or (177)Lu are new tracers with great potential for theranostic approaches in prostate cancer. However, clinical studies have shown that the kidneys are one of the off-target organs along with the salivary and lacrimal glands. In the kidneys, PSMA is physiologically expressed in the apical epithelium of the proximal tubules, and mannitol acts as an osmotic diuretic in these tubules. We investigated the potential of mannitol to reduce renal uptake of (68)Ga-PSMA...
August 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28800846/saprotrophic-proteomes-of-biotypes-of-the-witches-broom-pathogen-moniliophthora-perniciosa
#5
Sandra Pierre, Gareth W Griffith, Russell M Morphew, Luis A J Mur, Ian M Scott
Nine geographically diverse Moniliophthora perniciosa (witches' broom disease pathogen) isolates were cultured in vitro. They included six C-biotypes differing in virulence on cacao (Theobroma cacao), two S-biotypes (solanaceous hosts), and an L-biotype (liana hosts). Mycelial growth rates and morphologies differed considerably, but no characters were observed to correlate with virulence or biotype. In plant inoculations using basidiospores, one C-biotype caused symptoms on tomato (an S-biotype host), adding to evidence of limited host adaptation in these biotypes...
September 2017: Fungal Biology
https://www.readbyqxmd.com/read/28792452/complexes-of-oligoribonucleotides-with-d-mannitol-inhibit-hemagglutinin-glycan-interaction-and-suppress-influenza-a-virus-h1n1-a-fm-1-47-infectivity-in-vitro
#6
Nataliia Melnichuk, Larisa Semernikova, Zenoviy Tkachuk
The influenza virus hemagglutinin (HA) mediates both receptor (glycan) binding and membrane fusion for cell entry and has been the basis for subtyping influenza viruses. The oligoribonucleotides-d-mannitol (ORNs-d-M) complexes possess an anti-influenza activity in vitro and in vivo. In the present studies, we have found that ORNs-d-M interferes with hemagglutinin (HA)-glycan interaction and suppress viral infection in host cells. HA-glycan interactions were evaluated to indirectly quantify the amount of influenza virus titer by an agglutination assay...
August 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28782615/polyphenolic-protein-polysaccharide-ternary-conjugates-from-cystoseira-barbata-tunisian-seaweed-as-potential-biopreservatives-chemical-antioxidant-and-antimicrobial-properties
#7
Sabrine Sellimi, Abdelkarim Benslima, Veronique Barragan-Montero, Mohamed Hajji, Moncef Nasri
The present study investigated the antioxidant and antimicrobial activities of naturally occurring Cystoseira barbata seaweed glyco-conjugates (CBGs), with a view to developing safer food preservatives. CBGs were successfully isolated, then chemically and structurally characterized. CBGs contained a high amount of polysaccharides (49.76%) that consisted mainly of neutral sugars (47.67%) and uronic acids (2.09%). The carbohydrate fraction was sulfated (13.81%) and conjugated with proteins (9.86%) and phenolic compounds (4...
August 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28782124/supernatant-reduction-of-stored-gamma-irradiated-red-blood-cells-minimizes-potentially-harmful-substances-present-in-transfusion-aliquots-for-neonates
#8
Katherine Serrano, Chantale Pambrun, Elena Levin, Dana V Devine
BACKGROUND: In neonate transfusion, the use of a dedicated red blood cell (RBC) unit decreases donor exposure. A separate safety measure involves gamma irradiation of the RBCs to abrogate the possibility of transfusion-associated graft-versus-host disease. However, in combination, storage of gamma-irradiated RBCs leads to accumulation of potentially harmful substances in the supernatant. STUDY DESIGN AND METHODS: For this study, RBCs were pooled and split into three study arms...
August 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28780275/inhalable-sirna-loaded-nano-embedded-microparticles-engineered-using-microfluidics-and-spray-drying
#9
Monica Agnoletti, Adam Bohr, Kaushik Thanki, Feng Wan, Xianghui Zeng, Johan Peter Boetker, Mingshi Yang, Camilla Foged
Medicines based on small interfering RNA (siRNA) are promising for the treatment of a number of lung diseases. However, efficient delivery systems and design of stable dosage forms are required for inhalation therapy, as well as cost-effective methods for manufacturing of the final product. In this study, a 3D-printed micromixer was used for preparation of siRNA-dendrimer nanocomplexes, which were subsequently processed into microparticle-based dry powders for inhalation using spray drying. By applying the disposable micromixer, nanocomplexes were prepared of an average hydrodynamic diameter comparable to that of nanocomplexes prepared by manual mixing, but with narrower size distribution and low batch-to-batch variation...
August 2, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28777386/effect-of-mannitol-on-globe-and-orbital-volumes-in-humans
#10
Adam C Weber, Alexander D Blandford, Bryan R Costin, Julian D Perry
PURPOSE: To determine the effect of intravenous mannitol on globe and orbital volumes. METHODS: Retrospective chart review of a consecutive series of Cleveland Clinic Neurosurgical Intensive Care Unit patients who underwent computed tomographic imaging before and after intravenous mannitol administration. Volume measurements were performed according to a previously described technique by averaging axial image areas. Measurements before and after mannitol administration were compared using paired t-test...
August 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28773204/on-identification-of-critical-material-attributes-for-compression-behaviour-of-pharmaceutical-diluent-powders
#11
Jianyi Zhang, Chuan-Yu Wu, Xin Pan, Chuanbin Wu
As one of the commonly-used solid dosage forms, pharmaceutical tablets have been widely used to deliver active drugs into the human body, satisfying patient's therapeutic requirements. To manufacture tablets of good quality, diluent powders are generally used in formulation development to increase the bulk of formulations and to bind other inactive ingredients with the active pharmaceutical ingredients (APIs). For formulations of a low API dose, the drug products generally consist of a large fraction of diluent powders...
July 23, 2017: Materials
https://www.readbyqxmd.com/read/28770528/quiescent-and-agitated-redispersion-as-a-tool-for-evaluating-dispersant-effectiveness-in-dissolution-enhancement-of-drug-laden-nanocomposites
#12
A Bhakay, R N Davé, E Bilgili
Nanocomposite microparticles (NCMPs) have been used in various solid dosage forms with the goal of enhancing the dissolution rate and bioavailability of poorly water-soluble drugs. Nanoparticle recovery from NCMPs, i.e., redispersion, is the preliminary step in drug dissolution. This study aims at exploring aqueous redispersion of NCMPs with various dispersants under quiescent vs. agitated conditions as potential dispersant screening tool in the development of fast-dissolving NCMP formulations. NCMPs were prepared by coating wet-milled suspensions of a poorly water-soluble drug, griseofulvin (GF), formulated with the dispersants hydroxypropyl cellulose (HPC), sodium dodecyl sulfate (SDS), as-received/wet co-milled croscarmellose sodium (CCS), and mannitol, onto Pharmatose® carrier particles in a fluidized bed dryer...
August 2, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28768941/a-method-for-decreasing-the-amount-of-the-drug-remaining-on-the-surfaces-of-the-mortar-and-pestle-after-grinding-small-amount-of-tablets
#13
Miki Kawakami, Rika Kitada, Takuro Kurita, Tadakazu Tokumura
 The aim of the present study was to develop a method for grinding tablets with a mortar and pestle while reducing drug loss because grinding tablets is known to be associated with reductions in tablet weight and loss of the active drug. Seven kinds of tablets were subjected to grinding. The proportion (%) of the amount of the active drug in the powder remaining on the surfaces of the mortar and pestle relative to the total amount of the drug recovered (the recovery percent) was calculated. The recovery percent of the 7 kinds of tablets ranged from 17...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28767252/criegee-intermediates-react-with-levoglucosan-on-water
#14
Shinichi Enami, Michael R Hoffmann, A J Colussi
Levoglucosan (Levo), a C6-anhydrosaccharide produced in the combustion of cellulosic materials, is the major component of aerosols produced from biomass burning over vast regions worldwide. Levo has long been considered chemically inert and thus has been used as a tracer of biomass burning sources. However, we now show that sugars including Levo, glucose, arabitol, and mannitol react rapidly with Criegee intermediates (CIs) generated during the ozonolysis of sesquiterpenes on the surface of water:acetonitrile microjets...
August 7, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28765534/bacteriophages-as-potential-new-mammalian-pathogens
#15
George V Tetz, Kelly V Ruggles, Hua Zhou, Adriana Heguy, Aristotelis Tsirigos, Victor Tetz
Increased intestinal permeability and translocation of gut bacteria trigger various polyaetiological diseases associated with chronic inflammation and underlie a variety of poorly treatable pathologies. Previous studies have established a primary role of the microbiota composition and intestinal permeability in such pathologies. Using a rat model, we examined the effects of exposure to a bacteriophage cocktail on intestinal permeability and relative abundance of taxonomic units in the gut bacterial community...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763434/comparison-of-3-hypertonic-saline-and-20-mannitol-for-reducing-intracranial-pressure-in-patients-undergoing-supratentorial-brain-tumor-surgery-a-randomized-double-blind-clinical-trial
#16
Achmet Ali, Aylin Tetik, Pulat A Sabanci, Demet Altun, Nukhet Sivrikoz, Taner Abdullah, Aydin Aydoseli, Altay Sencer, Ibrahim O Akinci
BACKGROUND: In the present study, we hypothesized that 3% hypertonic saline (HS) is more effective than 20% mannitol to reduce intracranial pressure (ICP) and to modify brain bulk in patients undergoing an elective supratentorial craniotomy. MATERIALS AND METHODS: After institutional review board approval, patients scheduled to undergo supratentorial craniotomy were enrolled into this prospective, randomized, double-blind study. The patients were monitored for routine hemodynamic parameters, depth of anesthesia, and ICP...
July 31, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28759594/rapid-discrimination-of-strain-dependent-fermentation-characteristics-among-lactobacillus-strains-by-nmr-based-metabolomics-of-fermented-vegetable-juice
#17
Satoru Tomita, Katsuichi Saito, Toshihide Nakamura, Yasuyo Sekiyama, Jun Kikuchi
In this study, we investigated the applicability of NMR-based metabolomics to discriminate strain-dependent fermentation characteristics of lactic acid bacteria (LAB), which are important microorganisms for fermented food production. To evaluate the discrimination capability, six type strains of Lactobacillus species and six additional L. brevis strains were used focusing on i) the difference between homo- and hetero-lactic fermentative species and ii) strain-dependent characteristics within L. brevis. Based on the differences in the metabolite profiles of fermented vegetable juices, non-targeted principal component analysis (PCA) clearly separated the samples into those inoculated with homo- and hetero-lactic fermentative species...
2017: PloS One
https://www.readbyqxmd.com/read/28758965/identification-and-quantification-of-celery-allergens-using-fiber-optic-surface-plasmon-resonance-pcr
#18
Devin Daems, Bernd Peeters, Filip Delport, Tony Remans, Jeroen Lammertyn, Dragana Spasic
Abstract: Accurate identification and quantification of allergens is key in healthcare, biotechnology and food quality and safety. Celery (Apium graveolens) is one of the most important elicitors of food allergic reactions in Europe. Currently, the golden standards to identify, quantify and discriminate celery in a biological sample are immunoassays and two-step molecular detection assays in which quantitative PCR (qPCR) is followed by a high-resolution melting analysis (HRM). In order to provide a DNA-based, rapid and simple detection method suitable for one-step quantification, a fiber optic PCR melting assay (FO-PCR-MA) was developed to determine different concentrations of celery DNA (1 pM-0...
July 31, 2017: Sensors
https://www.readbyqxmd.com/read/28755991/optimization-of-high-concentration-endostatin-formulation-harmonization-of-excipients-contributions-on-colloidal-and-conformational-stabilities
#19
Shujing Wang, Xinyi Zhang, Guoliang Wu, Zhou Tian, Feng Qian
Recently, increasing research efforts have been devoted into developing high-concentration protein drugs for subcutaneous injection, especially for those with short half-lives and high-dose requirement. Proteins at high concentrations normally present increased colloidal and structural instability, such as aggregation, fibrillation and gelation, which significantly challenges the high-concentration formulation development of protein drugs. Here we used endostatin, a 20kD recombinant protein, as a model drug for high-concentration formulation optimization...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28755352/genetic-transformation-of-date-palm-via-microprojectile-bombardment
#20
Mousa Mousavi, Amir Mousavi, Ali A Habashi, Kazem Arzani, Bahareh Dehsara, Mohsen Brajeh
Efficient protocols for date palm embryogenic callus and somatic embryo transformation with uidA gene are described in this chapter. The embryogenic callus transformation procedure is 1.6 μm gold particle size coated with 2.5 μg DNA (pAct1-D plasmid), 1100 psi helium pressure, 9 cm target distance, 26 inHg vacuum pressure, 3 mm distance between the rupture disk and macrocarrier, and osmotic pretreatment with 0.4 M mannitol followed by 60 min air desiccation. The somatic embryo transformation procedure is 0...
2017: Methods in Molecular Biology
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