keyword
https://read.qxmd.com/read/38481667/optilume-drug-coated-balloon-for-anterior-urethral-stricture-2-year-results-of-the-robust-iii-trial
#21
JOURNAL ARTICLE
Maia E VanDyke, Allen F Morey, Karl Coutinho, Kaiser J Robertson, Richard D'Anna, Kent Chevli, Christopher H Cantrill, Michael J Ehlert, Alexis E Te, Jeffrey Dann, Jessica M DeLong, Ramón Virasoro, Judith C Hagedorn, Richard Levin, Euclid DeSouza, David DiMarco, Brad A Erickson, Carl Olsson, Sean P Elliott
OBJECTIVE: The aim of this study is to report the updated 2-year results of the intervention arm of the ROBUST III randomized trial evaluating the safety and efficacy of the Optilume drug-coated balloon (DCB) versus standard endoscopic management of recurrent male anterior urethral stricture. MATERIALS AND METHODS: Eligible patients included men with recurrent anterior urethral stricture ≤3 cm in length and ≤12Fr in diameter, International Prostate Symptom Score (IPSS) ≥11 and peak flow rate (Qmax) <15 mL/s...
March 2024: BJUI compass
https://read.qxmd.com/read/38481644/takotsubo-syndrome-associated-with-coronary-microvascular-dysfunction-a-case-study
#22
Shohei Ikeda, Morihiko Takeda, Koichi Sato, Mariko Shinozaki, Satomi Watanabe, Keita Miki, Michinori Hirano, Koji Fukuda, Nobuyuki Shiba
UNLABELLED: The patient, a 68-year-old man, presented to our emergency room with chest pain, prompting an emergency cardiac catheterization due to elevated cardiac troponin-I levels. While no obvious coronary artery stenosis was found, there was evidence of apical ballooning wall motion in the left ventricle, leading to a diagnosis of takotsubo syndrome. Three months later, he occasionally experienced chest pain at rest, prompting us to conduct another cardiac catheterization. Left ventriculography showed normal contraction...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38476194/has-collateral-blood-flow-any-effect-on-restenosis-rate-our-experience
#23
JOURNAL ARTICLE
Yanjiang Li, Yujie Sun, Tonghui Liu, Peng Liu, Guangwen Li, Yong Zhang
OBJECTIVES: Restenosis is one of the important factors affecting the effectiveness of percutaneous transluminal angioplasty and stenting in the treatment of intracranial atherosclerotic stenosis. We aimed to clarify whether recruitable collateral flow could cause restenosis in patients treated with percutaneous transluminal angioplasty and stenting. MATERIAL AND METHODS: Our study retrospectively analyzed patients with symptomatic severe intracranial atherosclerotic stenosis (≥70%) who underwent percutaneous transluminal angioplasty and stenting...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38470143/complex-n-glycans-are-important-for-interspecies-transmission-of-h7-influenza-a-viruses
#24
JOURNAL ARTICLE
Cindy M Spruit, Diana I Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R Sweet, Maryna Kuryshko, Joshua C L Maliepaard, Karli R Reiding, David Scheibner, Geert-Jan Boons, Elsayed M Abdelwhab, Robert P de Vries
Influenza A viruses (IAVs) can overcome species barriers by adaptation of the receptor-binding site of the hemagglutinin (HA). To initiate infection, HAs bind to glycan receptors with terminal sialic acids, which are either N -acetylneuraminic acid (NeuAc) or N -glycolylneuraminic acid (NeuGc); the latter is mainly found in horses and pigs but not in birds and humans. We investigated the influence of previously identified equine NeuGc-adapting mutations (S128T, I130V, A135E, T189A, and K193R) in avian H7 IAVs in vitro and in vivo ...
March 12, 2024: Journal of Virology
https://read.qxmd.com/read/38468724/operator-decision-making-in-angiography-only-guided-revascularization-for-lesions-not-indicated-for-ffr-a-qfr-based-functional-assessment-in-chronic-coronary-syndrome
#25
JOURNAL ARTICLE
Sadeek S Kanoun Schnur, Robertas Pranevičius, Cosima Stark, Dan Prunea, Judit Andreka, Albrecht Schmidt, Stefan Harb, Zoltan Ruzsa, Robert Zweiker, Jesse Kane, Gabor G Toth
BACKGROUND: Discordance between coronary angiographic findings and invasive functional significance is well-established. Yet, the prevalence of this mismatch in an era increasingly utilizing invasive functional assessments, such as fractional flow reserve (FFR), remains unclear. This study examines the extent of such discrepancies in current clinical practice. METHODS: This single-center prospective registry included consecutive patients with chronic coronary syndrome (CCS) who underwent elective coronary angiography, with or without revascularization...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38467916/flow-diversion-of-ruptured-intracranial-aneurysms-a-single-center-study-with-a-standardized-antithrombotic-treatment-protocol
#26
JOURNAL ARTICLE
Anni Rantamo, Camille Gallé, Jussi Numminen, Jyri Virta, Päivi Tanskanen, Ann-Christine Lindroos, Julio Resendiz-Nieves, Martin Lehecka, Mika Niemelä, Roel Haeren, Rahul Raj
BACKGROUND: The use of antithrombotic medication following acute flow diversion for a ruptured intracranial aneurysm (IA) is challenging with no current guidelines. We investigated the incidence of treatment-related complications and patient outcomes after flow diversion for a ruptured IA before and after the implementation of a standardized antithrombotic medication protocol. METHODS: We conducted a single-center retrospective study including consecutive patients treated for acutely ruptured IAs with flow diversion during 2015-2023...
March 11, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38466885/intraoperative-indocyanine-green-fluorescence-imaging-to-predict-early-hepatic-arterial-complications-after-liver-transplantation
#27
JOURNAL ARTICLE
Muga Terasawa, Hiroshi Imamura, Marc Antoine Allard, Daniel Pietrasz, Oriana Ciacio, Gabriella Pittau, Chady Salloum, Antonio Sa Cunha, Daniel Cherqui, René Adam, Daniel Azoulay, Akio Saiura, Eric Vibert, Nicolas Golse
PURPOSE: In liver transplantation (LT) setting, to propose an innovative intraoperative criterion to judge arterial flow abnormality that may lead to early hepatic arterial occlusion, i.e. thrombosis or stenosis, when left untreated and to carry out re-anastomosis. PATIENTS AND METHODS: After liver graft implantation, and after ensuring that there is no abnormality on the Doppler ultrasound (qualitative and quantitative assessment), we intraoperatively injected indocyanine green dye (ICG, 0...
March 7, 2024: Liver Transplantation
https://read.qxmd.com/read/38466450/blood-flow-evaluation-of-reconstructed-gastric-tube-in-esophageal-surgery-using-near-infrared-imaging-and-retrospective-time-intensity-curve-analysis
#28
JOURNAL ARTICLE
Nao Yamamoto, Hiroyuki Kitagawa, Kazumasa Orihashi, Keiichiro Yokota, Tsutomu Namikawa, Satoru Seo
PURPOSE: Near-infrared fluorescence imaging using indocyanine green (ICG-NIFI) can visualize a blood flow in reconstructed gastric tube; however, it depends on surgeon's visual assessment. The aim of this study was to re-analyze the ICG-NIFI data by an evaluator independent from the surgeon and feasibility of creating the time-intensity curve (TIC). METHODS: We retrospectively reviewed 97 patients who underwent esophageal surgery with gastric tube reconstruction between January 2017 and November 2022...
March 11, 2024: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/38465507/re-evaluation-of-nailfold-capillaroscopy-in-discriminating-primary-from-secondary-raynaud-s-phenomenon-and-in-predicting-systemic-sclerosis-a-randomised-observational-prospective-cohort-study
#29
JOURNAL ARTICLE
Marta C Amaral, F Seguro Paula, Joana Caetano, Paul Rj Ames, J Delgado Alves
BACKGROUND: Primary Raynaud's phenomenon (pRP) is difficult to distinguish from secondary (sRP). Although nailfold capillaroscopy (NFC) may detect early alterations, no universal criteria yet discriminate between pRP from sRP. OBJECTIVES: To create and validate two NFC scores that could distinguish pRP from sRP and that could predict systemic sclerosis (SSc), respectively. METHODS: We performed NFC on two separate cohorts with isolated RP, and recorded number of capillaries per field, enlarged/giant capillaries, crossed/bizarre patterns, microhemorrhages, neoangiogenesis, rarefaction, edema, blood flow velocity, stasis...
March 11, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38465216/ginseng-root-derived-exosome-like-nanoparticles-protect-skin-from-uv-irradiation-and-oxidative-stress-by-suppressing-activator-protein-1-signaling-and-limiting-the-generation-of-reactive-oxygen-species
#30
JOURNAL ARTICLE
Wooram Choi, Jeong Hun Cho, Sang Hee Park, Dong Seon Kim, Hwa Pyoung Lee, Donghyun Kim, Hyun Soo Kim, Ji Hye Kim, Jae Youl Cho
BACKGROUND: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. METHODS: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 109 particles/mL), and followed by UVB irradiation or H2 O2 exposure...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38461168/in-vivo-phenotypic-vascular-dysfunction-extends-beyond-the-aorta-in-a-mouse-model-for-fibrillin-1-fbn1-mutation
#31
JOURNAL ARTICLE
T Curry, M E Barrameda, T Currier Thomas, M Esfandiarei
In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (FBN1) mutations can lead to vascular wall weakening and dysfunction. The experimental mouse model of MFS (Fbn1C1041G/+ ) has been advantageous in investigating MFS-associated life-threatening aortic aneurysms. It is well established that the MFS mouse model exhibits an accelerated-aging phenotype in elastic organs like the aorta, lung, and skin. However, the impact of Fbn1 mutations on the in vivo function and structure of various artery types with the consideration of sex and age, has not been adequately explored in real-time and a clinically relevant context...
March 9, 2024: Scientific Reports
https://read.qxmd.com/read/38451334/six-methods-to-determine-expiratory-time-constants-in-mechanically-ventilated-patients-a-prospective-observational-physiology-study
#32
JOURNAL ARTICLE
Filip Depta, Caitlyn M Chiofolo, Nicolas W Chbat, Neil R Euliano, Michael A Gentile, Dušan Rybár, Viliam Donič, Marko Zdravkovic
BACKGROUND: Expiratory time constant (τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of obtaining τ are available, but they have not been compared. The purpose of this study was to compare six different methods to obtain τ and to test if the exponentially decaying flow corresponds to the measured time constants. METHODS: In this prospective study, pressure, flow, and volume waveforms of 30 postoperative patients undergoing volume (VCV) and pressure-controlled ventilation (PCV) were obtained using a data acquisition device and analyzed...
March 7, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38449912/non-ablative-erbium-yag-and-neodymium-yag-laser-treatment-for-anal-incontinence-and-vaginal-atrophy-a-case-study
#33
Nobuo Okui, Tadashi Ikegami, C Tamer Erel
In this case study, a 68-year-old woman with anal incontinence (AI) and vaginal atrophy (VVA), who did not respond to traditional treatments such as pelvic floor exercises or hormone therapy, underwent three sessions of laser treatment using RenovaLase (SP Dynamis; Fotona d.o.o., Ljubljana, Slovenia), which employs non-ablative Erbium:YAG and Neodymium:YAG lasers. Significant improvements were observed in the VVA symptoms, with AI being resolved. The Vaginal Health Index Score increased from 7 points at the initial assessment to 18 points at 12 months after treatment...
March 2024: Curēus
https://read.qxmd.com/read/38447436/coptisine-inhibits-neointimal-hyperplasia-through-attenuating-pak1-pak2-signaling-in-vascular-smooth-muscle-cells-without-retardation-of-re-endothelialization
#34
JOURNAL ARTICLE
Yuhan Chen, Xueze Jiang, Yuchan Yuan, Yuanyuan Chen, Sisi Wei, Ying Yu, Qing Zhou, Yi Yu, Julie Wang, Hua Liu, Xuesheng Hua, Zhenwei Yang, Zhiyong Chen, Yigang Li, Qunshan Wang, Jie Chen, Yuepeng Wang
BACKGROUND AND AIMS: Vascular injury-induced endothelium-denudation and profound vascular smooth muscle cells (VSMCs) proliferation and dis-regulated apoptosis lead to post-angioplasty restenosis. Coptisine (CTS), an isoquinoline alkaloid, has multiple beneficial effects on the cardiovascular system. Recent studies identified it selectively inhibits VSMCs proliferation. However, its effects on neointimal hyperplasia, re-endothelialization, and the underlying mechanisms are still unclear...
February 9, 2024: Atherosclerosis
https://read.qxmd.com/read/38444224/severe-hurricanes-increase-recruitment-and-gene-flow-in-the-clonal-sponge-aplysina-cauliformis
#35
JOURNAL ARTICLE
Iris Segura-García, Julie B Olson, Deborah J Gochfeld, Marilyn E Brandt, Andia Chaves-Fonnegra
Upright branching sponges, such as Aplysina cauliformis, provide critical three-dimensional habitat for other organisms and assist in stabilizing coral reef substrata, but are highly susceptible to breakage during storms. Breakage can increase sponge fragmentation, contributing to population clonality and inbreeding. Conversely, storms could provide opportunities for new genotypes to enter populations via larval recruitment, resulting in greater genetic diversity in locations with frequent storms. The unprecedented occurrence of two Category 5 hurricanes in close succession during 2017 in the U...
March 5, 2024: Molecular Ecology
https://read.qxmd.com/read/38443187/clinical-and-angiographic-characteristics-of-ruptured-and-unruptured-distal-cerebral-aneurysms-a-review-of-a-large-series-of-cases-in-a-high-volume-center
#36
JOURNAL ARTICLE
Roberta Cao, Adonis Mattar, Esteban Torche, Roberto Riva, Morgane Laubacher, Ricardo Moreno-Gomez, Francis Turjman, Andrea Falini, Pietro Panni, Omer F Eker
OBJECTIVE: To evaluate clinical, angiographic features, and endovascular approach of ruptured and unruptured distal intracranial aneurysms (DIAs). METHODS: From January 2013 to February 2022, details of all consecutive intracranial aneurysms (IAs) treated endovascularly in our center were collected and retrospectively reviewed. IAs involving the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery (distal to anterior communicating artery, limen insula, and P1 segment, respectively), and those distal to superior cerebellar artery, anterior-inferior cerebellar artery, and posterior inferior cerebellar artery's first segment were classified based on their etiology, location, size, and shape...
March 5, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38442175/utilizing-the-oxygen-atom-trapping-effect-of-co-3-o-4-with-oxygen-vacancies-to-promote-chlorite-activation-for-water-decontamination
#37
JOURNAL ARTICLE
Ruidian Su, Yixuan Gao, Long Chen, Yi Chen, Nan Li, Wen Liu, Baoyu Gao, Qian Li
Heterogeneous high-valent cobalt-oxo [≡Co(IV)=O] is a widely focused reactive species in oxidant activation; however, the relationship between the catalyst interfacial defects and ≡Co(IV)=O formation remains poorly understood. Herein, photoexcited oxygen vacancies (OVs) were introduced into Co3 O4 (OV-Co3 O4 ) by a UV-induced modification method to facilitate chlorite (ClO2 - ) activation. Density functional theory calculations indicate that OVs result in low-coordinated Co atom, which can directionally anchor chlorite under the oxygen-atom trapping effect...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38438483/time-band-network-model-and-binary-tree-algorithm-for-multimodal-irregular-flight-recovery
#38
JOURNAL ARTICLE
Peinan He
Recovery of irregular flights caused by various reasons such as aircraft failures and airport closures is studied in this research and a multimodal time-band network model for solving the issue is proposed. It transforms the flight routing problem into a time-based network, which is used to obtain the delay and cancellation costs of each flight. With delay and cancellation costs as variables, the proposed model aims to minimize recovery costs under constraints. This research also suggests a developed binary tree algorithm, which improves the efficiency of model solving...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38435223/rare-combination-of-chyloperitoneum-secondary-to-primary-small-bowel-volvulus
#39
Diogo Galvão, Rui Bettencourt, Ana Cláudia Soares, Inês Bagnari, Joana Bonança
Chylous ascites is the exudation from lymphatic content to the peritoneum and is a rare situation that mostly occurs following medical causes like neoplasms or cirrhosis. However, trauma to the lymphatic system due to compression by masses or altered anatomy can be a trigger too. We describe a rare combination of a primary small bowel volvulus in a young healthy adult causing chylous ascites. Obstruction caused by a primary small bowell volvulus can re-arrange the lymphatics anatomy increasing their flow pressure which can lead to rupture and leak...
February 2024: Curēus
https://read.qxmd.com/read/38434722/adipose-mesenchymal-stem-cell-derived-exosomes-promote-skin-wound-healing-in-diabetic-mice-by-regulating-epidermal-autophagy
#40
JOURNAL ARTICLE
Zhe Wang, Haiyue Ren, Peng Su, Feng Zhao, Qiqi Zhang, Xing Huang, Cai He, Quan Wu, Zitong Wang, Jiajie Ma
BACKGROUND: Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly in cases of refractory diabetic wounds. Interestingly, autophagy plays a role in wound healing, and recent research has demonstrated that exosomes are closely associated with intracellular autophagy in biogenesis and molecular signaling mechanisms. Therefore, this study aimed to investigate whether ADSC-Exos promote the repair of diabetic wounds by regulating autophagy to provide a new method and theoretical basis for the treatment of diabetic wounds...
2024: Burns and Trauma
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