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https://www.readbyqxmd.com/read/29137227/re-balance-of-memory-t-cell-subsets-in-peripheral-blood-from-patients-with-cml-after-tki-treatment
#1
Danlin Yao, Ling Xu, Jiaxiong Tan, Yikai Zhang, Shuai Lu, Mingde Li, Sichun Lu, Lijian Yang, Shaohua Chen, Jie Chen, Jing Lai, Yuhong Lu, Xiuli Wu, Xianfeng Zha, Yangqiu Li
T cell immune surveillance is considered an important host protection process for inhibiting carcinogenesis. The full capacity of T cell immune surveillance is dependent on T cell homeostasis, particularly for central memory T (TCM) cells and stem cell memory T (TSCM) cells. In this study, distribution of T cell subsets in peripheral blood from 12 patients with chronic myeloid leukemia (CML) and 12 cases with CML in complete remission (CR) was analyzed using a multicolor flow cytometer, and 16 samples from healthy individuals (HIs) served as control...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136872/a-novel-hybrid-flow-platform-for-on-line-simultaneous-dynamic-fractionation-and-evaluation-of-mercury-lability-in-environmental-solids
#2
Yanlin Zhang, Manuel Miró, Spas D Kolev
A method for the automatic simultaneous assessment of mobility and lability of mercury in environmental solid samples has been developed for the first time. It has been implemented in a hybrid flow system integrating flow-through dynamic sequential extraction and on-line chemical digestion prior to atomic fluorescence detection. The method allows the determination of trace concentrations of labile mercury (HgL) and non-labile mercury (HgNL) in different bioaccessible phases of environmental solid samples thus providing expeditious data not only for Hg exposome studies but also for the selection of suitable environmental remediation techniques...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136130/distal-re-entry-closure-with-neobranching-technique-after-thoracic-endovascular-aortic-repair-of-type-b-aortic-dissection
#3
Masaki Yamamoto, Takashi Fukutomi, Tatsuya Noguchi, Kazumasa Orihashi
Retrograde false-lumen flow after thoracic endovascular aortic repair of Type B aortic dissection occurs occasionally and may have a negative impact on aortic remodelling and even prevent the decompression of the false lumen. A 67-year-old man with a Type B aortic dissection underwent thoracic endovascular aortic repair for severe compression of the true lumen and visceral malperfusion 7 weeks after the onset. Intraoperative angiography revealed proximal entry tear closure, but the false-lumen flow increased because of retrograde flow through the re-entry tear...
November 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29132103/fixed-bed-column-studies-of-total-organic-carbon-removal-from-industrial-wastewater-by-use-of-diatomite-decorated-with-polyethylenimine-functionalized-pyroxene-nanoparticles
#4
Afif Hethnawi, Abdallah D Manasrah, Gerardo Vitale, Nashaat N Nassar
In this study, a fixed-bed column adsorption process was employed to remove organic pollutants from a real industrial wastewater effluent using polyethylenimine-functionalized pyroxene nanoparticles (PEI-PY) embedded into Diatomite at very low mass percentage. Various dynamic parameters (e.g., inlet concentration, inlet flow rate, bed height, and PEI-nanoparticle concentration in Diatomite, (%nps)) were investigated to determine the breakthrough behavior. The obtained breakthrough curves were fit with a convection-dispersion model to determine the characteristic parameters based on mass transfer phenomena...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29127049/predicting-mutant-selection-in-competition-experiments-with-ciprofloxacin-exposed-escherichia-coli
#5
David D Khan, Pernilla Lagerbäck, Christer Malmberg, Anders N Kristoffersson, Erik Gullberg, Cao Sha, Otto Cars, Dan I Andersson, Diarmaid Hughes, Elisabet I Nielsen, Lena E Friberg
Predicting competition between antibiotic susceptible wild-type and less susceptible mutant bacteria is valuable for understanding how drug concentrations influence emergence of resistance. Pharmacokinetic-pharmacodynamic (PKPD) models predicting the rate and extent of takeover of resistant bacteria during different antibiotic pressures can thereby be a valuable tool in improving treatment regimens. The aim of this study was to evaluate a previously developed mechanism-based PKPD model for its ability to predict in vitro mixed-population experiments with competition between E...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29123641/systematically-linking-transmart-galaxy-and-ega-for-reusing-human-translational-research-data
#6
Chao Zhang, Jochem Bijlard, Christine Staiger, Serena Scollen, David van Enckevort, Youri Hoogstrate, Alexander Senf, Saskia Hiltemann, Susanna Repo, Wibo Pipping, Mariska Bierkens, Stefan Payralbe, Bas Stringer, Jaap Heringa, Andrew Stubbs, Luiz Olavo Bonino Da Silva Santos, Jeroen Belien, Ward Weistra, Rita Azevedo, Kees van Bochove, Gerrit Meijer, Jan-Willem Boiten, Jordi Rambla, Remond Fijneman, J Dylan Spalding, Sanne Abeln
The availability of high-throughput molecular profiling techniques has provided more accurate and informative data for regular clinical studies. Nevertheless, complex computational workflows are required to interpret these data. Over the past years, the data volume has been growing explosively, requiring robust human data management to organise and integrate the data efficiently. For this reason, we set up an ELIXIR implementation study, together with the Translational research IT (TraIT) programme, to design a data ecosystem that is able to link raw and interpreted data...
2017: F1000Research
https://www.readbyqxmd.com/read/29122537/a-coil-placement-technique-to-treat-intracranial-aneurysm-with-incorporated-artery
#7
Chao-Bao Luo, Feng-Chi Chang, Chung-Jung Lin, Wan-Yuo Guo
BACKGROUND: Endovascular coil embolization is an accepted treatment option for intracranial aneurysms. However, the coiling of aneurysms with an incorporated artery (IA) poses a high risk of IA occlusion. Here we report our experience of endovascular coil placement using a technique that avoids IA occlusion in aneurysms with IAs. METHODS: Over a 6-year period, 185 patients harboring 206 intracranial aneurysms underwent endosaccular coiling. Forty-two of these patients with 45 aneurysms were treated by coil placement to avoid IAs occlusion...
November 6, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29120327/capillary-pericytes-mediate-coronary-no-reflow-after-myocardial-ischaemia
#8
Fergus M O'Farrell, Svetlana Mastitskaya, Matthew Hammond-Haley, Felipe Freitas, Wen Rui Wah, David Attwell
After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often occurs even after flow is restored in an upstream artery. This 'no-reflow' phenomenon worsens patient prognosis. In the brain, after stroke, a similar post-ischaemic 'no-reflow' has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, followed by reperfusion, blocks 40% of cardiac capillaries and halves perfused blood volume within the affected region. Capillary blockages colocalised strongly with pericytes, where capillary diameter was reduced by 37%...
November 9, 2017: ELife
https://www.readbyqxmd.com/read/29119185/polymer-conformation-during-flow-in-porous-media
#9
Durgesh Kawale, Gelmer Bouwman, Shaurya Sachdev, Pacelli L J Zitha, Michiel T Kreutzer, William R Rossen, Pouyan E Boukany
Molecular conformations of individual polymers during flow through porous media are directly observed by single-DNA imaging in microfluidics. As the Weissenberg number increases during flow (Wi > 1), we observe two types of elastic instabilities: (a) stationary dead-zone and (b) time-dependant dead-zone washing. When stretched polymer chains enter a dead-zone, they first re-coil and, once inside the dead-zone, they rotate and re-stretch again. The probability distribution of DNA chains under the stretched condition inside the dead-zone is found to be heterogeneous with a broad distribution...
November 9, 2017: Soft Matter
https://www.readbyqxmd.com/read/29118868/efficacy-of-video-capsule-endoscopy-in-the-management-of-suspected-small-bowel-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#10
Thomas A Zikos, Jennifer Pan, Berkeley Limketkai, Dipanjan Banerjee, Nielsen Fernandez-Becker
Background: Continuous flow left ventricular assist device (CF-LVAD) patients have a high prevalence of gastrointestinal bleeding from the small bowel. Video capsule endoscopy (VCE) is often used for diagnosis in these patients, but efficacy has yet to be determined. In this study, we evaluated the efficacy of VCE in the management of CF-LVAD patients with suspected small bowel bleeding by comparing to a non-VCE CF-LVAD control group. Methods: We retrospectively reviewed the charts of all patients with CF-LVADs implanted at Stanford Hospital from January 2010 to October 2015...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29117039/optimization-of-axial-pump-characteristic-dimensions-and-induced-hemolysis-for-mechanical-circulatory-support-devices
#11
Theodosios Korakianitis, Mohammad A Rezaienia, Gordon M Paul, Eldad J Avital, Martin T Rothman, Sahand Mozafari
The application of axial pumps as ventricular assist devices (VADs) requires significant modifications to the size and characteristics of industrial pumps due to the difference in flow fields of industrial and medical pumps. Industrial pumps operate in the region of Reynolds number Re = 108, whereas axial blood pumps operate in Re < 10. The common pump design technique is to rely on the performance of previously designed pumps using the concept of fluid dynamic similarity. Such data are available for industrial pumps as specific speed-specific diameter (ns-ds) graphs...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29105215/re-outcome-of-monochorionic-twin-pregnancy-with-selective-intrauterine-growth-restriction-according-to-umbilical-artery-doppler-flow-pattern-of-smaller-twin-systematic-review-and-meta-analysis-d-buca-g-pagani-g-rizzo-a-familiari-m-e-flacco-l-manzoli-m-liberati
#12
COMMENT
https://www.readbyqxmd.com/read/29104752/combined-analysis-of-the-safety-of-intra-coronary-drug-delivery-during-primary-percutaneous-coronary-intervention-for-acute-myocardial-infarction-a-study-of-three-clinical-trials
#13
Krishnaraj S Rathod, Stephen Hamshere, Rayomand S Khambata, Mervyn Andiapen, Mark Westwood, Anthony Mathur, Amrita Ahluwalia, Daniel A Jones
Background: The local injection of novel cardioprotective study drugs prior to percutaneous coronary intervention could cause embolisation of thrombus, resulting in increased reperfusion injury and subsequent infarct size. The aim of this study was to assess the safety of the delivery of an intracoronary therapy delivered during primary percutaneous coronary intervention for acute myocardial infarction prior to the re-establishment of thrombolysis in myocardial infarction III flow. Methods: One hundred sixty-seven patients with acute myocardial infarction successfully reperfused through primary percutaneous coronary intervention and undergoing Cardiac MRI within the first week after reperfusion were studied...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29104688/one-step-surgery-for-cutaneous-melanoma-we-cannot-solve-our-problems-with-the-same-thinking-we-used-when-we-created-them
#14
Georgi Tchernev
One step melanoma surgery is, in fact, an innovative combined method for diagnosis and treatment of cutaneous melanoma (at the same time). The methodology allows an accurate assessment of the actual status of the affected patients by 1) clinical status, dermatoscopy, high-frequent ultrasonography (HFUS) of the pigmented lesion (eventually in combination with normal lymph nodes ultrasonography), followed by a single surgical intervention. Within this intervention, the primary tumour is removed with the appropriate surgical field, with or without parallel detection and draining lymph node biopsy (depending on the established tumour thickness)...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104327/dayside-response-of-the-magnetosphere-to-a-small-shock-compression-van-allen-probes-magnetospheric-multiscale-and-goes-13
#15
C Cattell, A Breneman, C Colpitts, J Dombeck, S Thaller, S Tian, J Wygant, J Fennell, M K Hudson, Robert Ergun, C T Russell, Roy Torbert, Per-Arne Lindqvist, J Burch
Observations from Magnetospheric MultiScale (~8 Re) and Van Allen Probes (~5 and 4 Re) show that the initial dayside response to a small interplanetary shock is a double-peaked dawnward electric field, which is distinctly different from the usual bipolar (dawnward and then duskward) signature reported for large shocks. The associated E × B flow is radially inward. The shock compressed the magnetopause to inside 8 Re, as observed by Magnetospheric MultiScale (MMS), with a speed that is comparable to the E × B flow...
September 16, 2017: Geophysical Research Letters
https://www.readbyqxmd.com/read/29103599/three-dimensional-discrete-element-method-for-the-prediction-of-protoplasmic-seepage-through-membrane-in-a-biological-cell
#16
Kelvin K L Wong
This paper presents a three-dimensional and compressible biological cell model based on discrete element method using multiple interacting agent that represent cellular structures within a simulated environment. The cytoplasm and nucleoplasm fluid behavior in the cell is time dependent. When taking this approach, it is important to calibrate protoplasmic flow behaviors through simulation techniques such as compressing the cell and examining the agents representing the cell cytoplasm seeping between the ones representing the confining cell membrane...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29101020/angiography-based-quantitative-flow-ratio-for-online-assessment-of-coronary-stenosis-favor-ii-china-study
#17
Bo Xu, Shengxian Tu, Shubin Qiao, Xinkai Qu, Yundai Chen, Junqing Yang, Lijun Guo, Zhongwei Sun, Zehang Li, Feng Tian, Weiyi Fang, Jiyan Chen, Wei Li, Changdong Guan, Niels R Holm, William Wijns, Shengshou Hu
OBJECTIVES: To assess the diagnostic performance of quantitative flow ratio (QFR) for diagnosis of hemodynamically-significant coronary stenosis defined by fractional flow reserve (FFR) ≤0.80. BACKGROUND: QFR is a novel angiography-based method for deriving FFR without pressure wire or induction of hyperemia. The accuracy of QFR when assessed online in the catheterization laboratory has not been adequately examined to date. METHODS: This prospective, multicenter trial enrolled patients who had at least one lesion with diameter stenosis of 30-90% and reference diameter ≥ 2mm by visual estimation...
October 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29099612/diagnostic-performance-and-useful-findings-of-ultrasound-re-evaluation-for-patients-with-equivocal-ct-features-of-acute-appendicitis
#18
Mi Sung Kim, Heon-Ju Kwon, Kyung A Kang, In-Gu Do, Hee-Jin Park, Eun Young Kim, Hyun Pyo Hong, Yoon Jung Choi, Young Hwan Kim
OBJECTIVE: To evaluate the diagnostic performance of ultrasound (US) and to determine which US findings are useful to differentiate appendicitis from non-appendicitis in patients who underwent US re-evaluation due to equivocal computed tomography (CT) features of acute appendicitis. METHODS: Sixty-two patients who underwent CT examinations for suspected appendicitis followed by US re-evaluation due to equivocal CT findings were included. Equivocal CT findings were considered based on the presence of only one or two findings among the CT criteria, and US re-evaluation was done based on a pre-defined structured report form...
November 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29099199/dynamo-action-in-a-quasi-keplerian-taylor-couette-flow
#19
Anna Guseva, Rainer Hollerbach, Ashley P Willis, Marc Avila
We numerically compute the flow of an electrically conducting fluid in a Taylor-Couette geometry where the rotation rates of the inner and outer cylinders satisfy Ω_{o}/Ω_{i}=(r_{o}/r_{i})^{-3/2}. In this quasi-Keplerian regime, a nonmagnetic system would be Rayleigh stable for all Reynolds numbers Re, and the resulting purely azimuthal flow incapable of kinematic dynamo action for all magnetic Reynolds numbers Rm. For Re = 10^{4} and Rm=10^{5}, we demonstrate the existence of a finite-amplitude dynamo, whereby a suitable initial condition yields mutually sustaining turbulence and magnetic fields, even though neither could exist without the other...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29098228/proxyphos-sensors-for-the-detection-of-negatively-charged-membranes
#20
Bronte I Murcar-Evans, Aaron D Cabral, Krimo Toutah, Elvin D de Araujo, Angel Lai, Peter M Macdonald, Angelika Berger-Becvar, Dziyana Kraskouskaya, Patrick T Gunning
Membrane-embedded negatively charged phospholipids (MENCP) can be used as biomarkers for a range of biological processes, including early detection of apoptosis in animal cells, drug-induced phospholipidosis, and selective detection of bacterial over animal cells. Currently, several technologies for the detection of apoptosis and bacterial cells are based on the recognition of MENCPs, including the AnnexinV stain and PSVue™ probes. As probes, these technologies have limitations, the most significant of which is the need for washing the unbound probe away to achieve optimal signal...
November 3, 2017: Analyst
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