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https://www.readbyqxmd.com/read/29331052/flow-pattern-analysis-in-type-b-aortic-dissection-patients-after-stent-grafting-repair-comparison-between-complete-and-incomplete-false-lumen-thrombosis
#1
Wan Naimah Wan Ab Naim, Poo Balan Ganesan, Zhonghua Sun, Jing Lei, Shirley Jansen, Shahrul Amry Hashim, Teik Kok Ho, Einly Lim
Endovascular stent graft repair has become a common treatment for complicated Stanford Type B aortic dissection in order to restore true lumen flow and induce false lumen thrombosis. Using computational fluid dynamics, this study reports the differences in flow patterns and wall shear stress distribution in complicated Stanford Type B aortic dissection patients after endovascular stent graft repair. Five patients were included in this study: two having more than 80% false lumen thrombosis (Group 1), while three others had less than 80% false lumen thrombosis (Group 2) within one year following endovascular repair...
January 13, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29329092/effect-of-aspirin-on-the-pharmacokinetics-and-absorption-of-panax-notoginseng-saponins
#2
Zhihao Tian, Huanhuan Pang, Qiang Zhang, Shouying Du, Yang Lu, Lin Zhang, Jie Bai, Pengyue Li, Danqi Li, Mengdi Zhao, Xiaonan Chen
BACKGROUND: Panax notoginseng saponins, a traditional Chinese medicine extraction, and aspirin are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved, when Panax notoginseng saponins was taken together with aspirin. METHODS: To investigate the interaction of the two drugs in vivo, the concentration of notoginsenoside R1, ginsenoside Rg1, Rb1, Re and Rd. in blood were simultaneously measured by UPLC/MS/MS...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29329053/long-term-safety-area-tracking-lt-sat-with-online-failure-detection-and-recovery-for-robotic-minimally-invasive-surgery
#3
Veronica Penza, Xiaofei Du, Danail Stoyanov, Antonello Forgione, Leonardo S Mattos, Elena De Momi
Despite the benefits introduced by robotic systems in abdominal Minimally Invasive Surgery (MIS), major complications can still affect the outcome of the procedure, such as intra-operative bleeding. One of the causes is attributed to accidental damages to arteries or veins by the surgical tools, and some of the possible risk factors are related to the lack of sub-surface visibilty. Assistive tools guiding the surgical gestures to prevent these kind of injuries would represent a relevant step towards safer clinical procedures...
December 22, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29327177/influence-of-sampling-frequency-and-load-calculation-methods-on-quantification-of-annual-river-nutrient-and-suspended-solids-loads
#4
Ahmed Elwan, Ranvir Singh, Maree Patterson, Jon Roygard, Dave Horne, Brent Clothier, Geoffrey Jones
Better management of water quality in streams, rivers and lakes requires precise and accurate estimates of different contaminant loads. We assessed four sampling frequencies (2 days, weekly, fortnightly and monthly) and five load calculation methods (global mean (GM), rating curve (RC), ratio estimator (RE), flow-stratified (FS) and flow-weighted (FW)) to quantify loads of nitrate-nitrogen (NO3--N), soluble inorganic nitrogen (SIN), total nitrogen (TN), dissolved reactive phosphorus (DRP), total phosphorus (TP) and total suspended solids (TSS), in the Manawatu River, New Zealand...
January 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29324280/effective-phospholipids-removing-microelution-solid-phase-extraction-lc-ms-ms-method-for-simultaneous-plasma-quantification-of-aripiprazole-and-dehydro-aripiprazole-application-to-human-pharmacokinetic-studies
#5
Aneta Wojnicz, Carmen Belmonte, Dora Koller, Ana Ruiz-Nuño, Manuel Román, Dolores Ochoa, Francisco Abad Santos
A simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for simultaneous quantification of aripiprazole and its active metabolite, dehydro-aripiprazole, in human plasma. Stable isotopically labeled aripiprazole, aripiprazole-D8, has been used as the internal standard (IS) for both analytes. Only 200 μl of human plasma was needed for analyte extraction, using effective phospholipids-eliminating three-step microelution-solid-phase extraction (SPE, Oasis PRiME HLB 96-well μElution Plate)...
December 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29310297/selective-amperometric-flow-injection-analysis-of-carbofuran-using-a-molecularly-imprinted-polymer-and-gold-coated-magnetite-modified-carbon-nanotube-paste-electrode
#6
Maliwan Amatatongchai, Wongduan Sroysee, Purim Jarujamrus, Duangjai Nacapricha, Peter A Lieberzeit
Herein, we propose a new approach for selective determination of carbofuran (CBF) in vegetables, based on a simple flow-injection system using a molecularly-imprinted amperometric sensor. The sensor design is based on a carbon-paste electrode decorated with carbon nanotubes and gold-coated magnetite (CNTs-Fe3O4@Au/CPE) coated with a molecularly-imprinted polymer (MIP) for CBF sensing. The MIP was synthesized on the electrode surface by electropolymerization using a supramolecular complex, namely 4-ter-butylcalix [8] arene-CBF (4TB[8]A-CBF), as the template...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29309860/effects-of-total-saponins-from-trillium-tschonoskii-rhizome-on-grey-and-white-matter-injury-evaluated-by-quantitative-multiparametric-mri-in-a-rat-model-of-ischemic-stroke
#7
Manzhong Li, Junyao Ouyang, Yi Zhang, Brian Chi Yan Cheng, Yu Zhan, Le Yang, Haiyan Zou, Hui Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Trillium tschonoskii rhizome (TTR), a medicinal herb, has been traditionally used to treat traumatic brain injury and headache in China. Although the potential neuroprotective efficacy of TTR has gained increasing interest, the pharmacological mechanism remains unclear. Steroid saponins are the main bioactive components of the herb. AIM OF THE STUDY: To investigate the protective and repair-promoting effects of the total saponins from TTR (TSTT) on grey and white matter damages in a rat model of middle cerebral artery occlusion (MCAO) using magnetic resonance imaging (MRI) assay...
January 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29305674/comparable-osteogenic-capacity-of-mesenchymal-stem-or-stromal-cells-derived-from-human-amnion-membrane-and-bone-marrow
#8
Mehran Ghasemzadeh, Ehteramolsadat Hosseini, Mohammadhossein Ahmadi, Maedeh Kamalizad, Naser Amirizadeh
So far, substantial attentions have been attracted to the application of mesenchymal stem or stromal cells (MSCs) in different therapeutic approaches. Although human bone marrow is commonly considered as a major source for MSCs, having an invasive collection method, ethical consideration and donor availability create a challenge for scientists, leading them to explore better alternative sources for MSCs. The study presented here aimed to characterize and compare osteogenic capacity of MSCs obtained from the amnion membrane (AM) with those originated from BM...
January 5, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29286796/buckling-instability-causes-inertial-thrust-for-spherical-swimmers-at-all-scales
#9
Adel Djellouli, Philippe Marmottant, Henda Djeridi, Catherine Quilliet, Gwennou Coupier
Microswimmers, and among them aspirant microrobots, generally have to cope with flows where viscous forces are dominant, characterized by a low Reynolds number (Re). This implies constraints on the possible sequences of body motion, which have to be nonreciprocal. Furthermore, the presence of a strong drag limits the range of resulting velocities. Here, we propose a swimming mechanism which uses the buckling instability triggered by pressure waves to propel a spherical, hollow shell. With a macroscopic experimental model, we show that a net displacement is produced at all Re regimes...
December 1, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29283127/rescue-of-failing-or-failed-trabeculectomy-blebs-with-slit-lamp-needling-and-adjunctive-mitomycin-c-in-indian-eyes
#10
Vanita Pathak-Ray, Nikhil Choudhari
PURPOSE: The aim of this study is to investigate the efficacy and safety of needling-revision augmented with a high dose of mitomycin C (MMC) in failing or failed blebs after trabeculectomy in Indian eyes. METHODS: Prospective, noncomparative, interventional study. All patients (>18 years) who had raised intraocular pressure (IOP) following trabeculectomy (>6 weeks and <2 years), who had a flat bleb, bleb encapsulation, and/or required antiglaucoma medication (AGM) for IOP control were eligible for inclusion...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280545/perforated-balloon-technique-a-simple-and-handy-technique-to-combat-no-reflow-phenomenon-in-coronary-system
#11
Tejas Patel, Sanjay Shah, Rajiv Gulati, Tak Kwan, Mauricio G Cohen, Samir Pancholy
OBJECTIVE: Examining the efficacy and outcomes of intracoronary (IC) instillation of adenosine using a novel perforated balloon technique (PBT) to combat no-reflow phenomenon during percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). BACKGROUND: Occurrence of no-reflow during PCI is a serious adverse prognostic event and inability to re-establish better flow is associated with poor outcomes. Several pharmacological and non-pharmacological interventions have been used to treat this situation...
December 27, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29277587/the-use-of-flow-diverter-in-ruptured-dissecting-intracranial-aneurysms-of-the-posterior-circulation
#12
Volker Maus, Anastasios Mpotsaris, Franziska Dorn, Markus Möhlenbruch, Jan Borggrefe, Pantelis Stavrinou, Nuran Abdullayev, Utako Birgit Barnikol, Thomas Liebig, Christoph Kabbasch
OBJECTIVE: Acute dissecting aneurysms of the posterior circulation are a rare cause of SAH. Established endovascular treatment options include PAO and stent-assisted coiling, but appear to be associated with an increased risk of ischemic stroke. Vessel reconstruction with flow-diverters is an alternative treatment option, however, its safety and efficacy in the acute stage remains unclear. METHODS: Multi-centric retrospective analysis of 15 consecutive acutely ruptured dissecting posterior circulation aneurysms treated with flow-diverters...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29275303/effect-of-increased-intra-abdominal-pressure-on-liver-histology-and-hemodynamics-an-experimental-study
#13
Efstathios A Antoniou, Evi Kairi, Georgios A Margonis, Nikolaos Andreatos, Kazunari Sasaki, Christos Damaskos, Nikolaos Garmpis, Mario Samaha, Eriphyli Argyra, George Polymeneas, Matthew J Weiss, Timothy M Pawlik, Dionysios Voros, Gregory Kouraklis
BACKGROUND: While reduction of portal venous (PV) blood flow has been described in animal models of intra-abdominal hypertension, reports on compensatory changes in hepatic arterial (HA) flow, known as the hepatic arterial buffer response are controversial. MATERIALS AND METHODS: Pneumoperitoneum with helium was induced in 13 piglets. Hemodynamic measurements and pathological assessment were conducted at baseline and during the three subsequent phases: Phase A: 45 minutes with a stable intra-abdominal pressure of 25 mmHg; phase B: 45 minutes with a stable intra-abdominal pressure of 40 mmHg; and phase C during which the abdomen was re-explored and reperfusion of the liver was allowed to take place...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29273977/negative-igg-varicella-zoster-virus-antibody-status-immune-responses-pre-and-post-re-immunization
#14
Tamar A Smith-Norowitz, Tehila A Saadia, Kevin B Norowitz, Rauno Joks, Helen G Durkin, Stephan Kohlhoff
INTRODUCTION: Varicella zoster virus (VZV) causes chicken pox and herpes zoster and is a self-limiting disease in healthy children. Vaccination is recommended for children, adolescents, and adults. This study discusses a healthy pediatric patient with negative immunoglobulin (Ig) G VZV antibody (Ab) status after two doses of varicella vaccine and then subsequently re-immunized. Since measurement of serum IgG titers alone may not reflect vaccine protection, we further evaluated cell-mediated and humoral immune responses before and after re-immunization...
December 22, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29272974/home-oxygen-therapy-re-thinking-the-role-of-devices
#15
Andrea S Melani, Piersante Sestini, Paola Rottoli
A range of devices are available for delivering and monitoring Home Oxygen Therapy (HOT). Guidelines do not give indications for the choice of the delivery device but recommend the use of an ambulatory system in subjects on HOT whilst walking. Areas covered: We provide a clinical overview of HOT and review traditional and newer delivery and monitoring devices for HOT. Despite relevant technology advancements, clinicians, faced with many challenges when they prescribe oxygen therapy, often remain familiar to traditional devices and continuous flow delivery of oxygen...
December 22, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29259996/phenotypic-and-functional-complexity-of-brain-infiltrating-t-cells-in-rasmussen-encephalitis
#16
Faiez Al Nimer, Ivan Jelcic, Christian Kempf, Tom Pieper, Herbert Budka, Mireia Sospedra, Roland Martin
Objective: To characterize the brain-infiltrating immune cell repertoire in Rasmussen encephalitis (RE) with special focus on the subsets, clonality, and their cytokine profile. Methods: The immune cell infiltrate of freshly isolated brain tissue from RE was phenotypically and functionally characterized using immunohistology, flow cytometry, and T-cell receptor (TCR) deep sequencing. Identification of clonally expanded T-cell clones (TCCs) was achieved by combining flow cytometry sorting of CD4+ and CD8+ T cells and high-throughput TCR Vβ-chain sequencing...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29258855/camptosorus-sibiricus-rupr-aqueous-extract-prevents-lung-tumorigenesis-via-dual-effects-against-ros-and-dna-damage
#17
Shugui He, Rilan Ou, Wensheng Wang, Liyan Ji, Hui Gao, Yuanfeng Zhu, Xiaomin Liu, Hongming Zheng, Zhongqiu Liu, Peng Wu, Linlin Lu
ETHNOPHARMACOLOGICAL RELEVANCE: Camptosorus sibiricus Rupr (CSR) is a widely used herbal medicine with antivasculitis, antitrauma, and antitumor effects. However, the effect of CSR aqueous extract on B[a]P-initiated tumorigenesis and the underlying mechanism remain unclear. Moreover, the compounds in CSR aqueous extract need to be identified and structurally characterized. AIM OF THE STUDY: We aim to investigate the chemopreventive effect of CSR and the underlying molecular mechanism...
December 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29258534/a-3d-subject-specific-model-of-the-spinal-subarachnoid-space-with-anatomically-realistic-ventral-and-dorsal-spinal-cord-nerve-rootlets
#18
Lucas R Sass, Mohammadreza Khani, Gabryel Connely Natividad, R Shane Tubbs, Olivier Baledent, Bryn A Martin
BACKGROUND: The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry with multiple levels of anatomic complexity, the most salient features being the spinal cord and dorsal and ventral nerve rootlets. An accurate anthropomorphic representation of these features is needed for development of in vitro and numerical models of cerebrospinal fluid (CSF) dynamics that can be used to inform and optimize CSF-based therapeutics. METHODS: A subject-specific 3D model of the SSS was constructed based on high-resolution anatomic MRI...
December 19, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29258497/non-invasive-genetic-monitoring-involving-citizen-science-enables-reconstruction-of-current-pack-dynamics-in-a-re-establishing-wolf-population
#19
Hanna Granroth-Wilding, Craig Primmer, Meri Lindqvist, Jenni Poutanen, Olaf Thalmann, Jouni Aspi, Jenni Harmoinen, Ilpo Kojola, Toni Laaksonen
BACKGROUND: Carnivores are re-establishing in many human-populated areas, where their presence is often contentious. Reaching consensus on management decisions is often hampered by a dispute over the size of the local carnivore population. Understanding the reproductive dynamics and individual movements of the carnivores can provide support for management decisions, but individual-level information can be difficult to obtain from elusive, wide-ranging species. Non-invasive genetic sampling can yield such information, but makes subsequent reconstruction of population history challenging due to incomplete population coverage and error-prone data...
December 19, 2017: BMC Ecology
https://www.readbyqxmd.com/read/29251332/suppression-of-kpn%C3%AE-1-expression-inhibits-human-breast-cancer-cell-proliferation-by-abrogating-nuclear-transport-of-her2
#20
Chenyi Sheng, Jian Qiu, Zhixian He, Hua Wang, Qingqing Wang, Zengya Guo, Lianxin Zhu, Qichao Ni
Breast cancer (BC) is one of the most fatal diseases and poses critical health problems worldwide. However, its mechanisms remain unclear. Consequently, there is an urgency to investigate the mechanisms involved in BC initiation and progression and identify novel therapeutics for its prevention and treatment. In this study, we identified karyopherin β-1 (Kpnβ1) as a possible novel therapeutic target for BC. Western blotting was used to evaluate the expression of Kpnβ1 in four pairs of tumorous and adjacent non-tumorous tissues...
February 2018: Oncology Reports
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