keyword
https://read.qxmd.com/read/38474251/the-efficacy-of-stem-cells-in-wound-healing-a-systematic-review
#21
REVIEW
Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai
Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473833/changes-in-the-concentrations-of-proangiogenic-cytokines-in-human-brain-glioma-and-acute-lymphoblastic-leukemia
#22
JOURNAL ARTICLE
Lukasz Oldak, Zuzanna Zielinska, Patrycja Milewska, Sylwia Chludzinska-Kasperuk, Eryk Latoch, Katarzyna Konończuk, Maryna Krawczuk-Rybak, Aleksandra Starosz, Kamil Grubczak, Joanna Reszeć, Ewa Gorodkiewicz
Acute lymphoblastic leukemia (ALL) and glioma are some of the most common malignancies, with ALL most often affecting children and glioma affecting adult men. Proangiogenic cytokines and growth factors play an important role in the development of both of these tumors. Glioma is characterized by an extremely extensive network of blood vessels, which continues to expand mainly in the process of neoangiogenesis, the direct inducers of which are cytokines from the family of vascular endothelial growth factors, i...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473413/pancreatic-cancer-treatment-targeting-the-hgf-c-met-pathway-the-mek-inhibitor-trametinib
#23
REVIEW
Junyeol Kim, Tae Seung Lee, Myeong Hwan Lee, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Sang Hyub Lee, Woo Hyun Paik
Pancreatic cancer is characterized by fibrosis/desmoplasia in the tumor microenvironment, which is primarily mediated by pancreatic stellate cells and cancer-associated fibroblasts. HGF/c-MET signaling, which is instrumental in embryonic development and wound healing, is also implicated for its mitogenic and motogenic properties. In pancreatic cancer, this pathway, along with its downstream signaling pathways, is associated with disease progression, prognosis, metastasis, chemoresistance, and other tumor-related factors...
March 5, 2024: Cancers
https://read.qxmd.com/read/38473244/advances-in-3d-culture-models-to-study-exosomes-in-triple-negative-breast-cancer
#24
REVIEW
Neelum Aziz Yousafzai, Lamyae El Khalki, Wei Wang, Justin Szpendyk, Khalid Sossey-Alaoui
Breast cancer, a leading cause of cancer-related deaths globally, exhibits distinct subtypes with varying pathological, genetic, and clinical characteristics. Despite advancements in breast cancer treatments, its histological and molecular heterogeneity pose a significant clinical challenge. Triple-negative breast cancer (TNBC), a highly aggressive subtype lacking targeted therapeutics, adds to the complexity of breast cancer treatment. Recent years have witnessed the development of advanced 3D culture technologies, such as organoids and spheroids, providing more representative models of healthy human tissue and various malignancies...
February 22, 2024: Cancers
https://read.qxmd.com/read/38472732/exosomes-derived-from-mouse-breast-carcinoma-cells-facilitate-diabetic-wound-healing
#25
JOURNAL ARTICLE
Chao Zhang, Wenchi Xiao, Hao Wang, Linxiao Li, Yan Yang, Yongwei Hao, Zhihao Xu, Hongli Chen, Wenbin Nan
BACKGROUND: Exosomes derived from breast cancer have been reported to play a role in promoting cell proliferation, migration, and angiogenesis, which has the potential to accelerate the healing process of diabetic wounds. The aim of this investigation was to examine the function of exosomes originating from 4T1 mouse breast carcinoma cells (TEXs) in the process of diabetic wound healing. METHODS: The assessment of primary mouse skin fibroblasts cell proliferation and migration was conducted through the utilization of CCK-8 and wound healing assays, while the tube formation of HUVECs was evaluated by tube formation assay...
March 12, 2024: Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/38460375/exosomal-ncrnas-multifunctional-contributors-to-the-immunosuppressive-tumor-microenvironment-of-hepatocellular-carcinoma
#26
REVIEW
Qi Huang, Xin Zhong, Jing Li, Rui Hu, Jinyu Yi, Jialing Sun, Youhua Xu, Xiaozhou Zhou
Hepatocellular carcinoma (HCC) is a malignant liver cancer characterized by aggressive progression, unfavorable prognosis, and an increasing global health burden. Therapies that precisely target immunological checkpoints and immune cells have gained significant attention as possible therapeutics in recent years. In truth, the efficacy of immunotherapy is heavily contingent upon the tumor microenvironment (TME). Recent studies have indicated that exosomes serve as a sophisticated means of communication among biomolecules, executing an essential part in the TME of immune suppression...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38460368/intra-abdominal-transplantation-of-plga-pcl-m13-phage-electrospun-scaffold-induces-self-assembly-of-lymphoid-tissue-like-structure
#27
JOURNAL ARTICLE
Zohreh Safari, Majid Sadeghizadeh, Ahmad Zavaran Hosseini, Ali Hazrati, Sara Soudi
Lymphoid organs are the main structural components of the immune system. In the current research, the mixture of poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and M13 phage or its RGD-modified form was used in the construction of a fibrillar scaffold using the electrospinning method. The constructs were transplanted intra-abdominally and examined for the formation of lymphoid-like tissues at different time intervals. The confocal and scanning electron microscopy demonstrate that M13 phage-containing scaffolds provide a suitable environment for lymph node-isolated fibroblasts...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38459796/in-vivo-assessment-of-application-of-folinic-acid-and-botulinum-toxin-a-in-cleft-lip-surgical-defects
#28
JOURNAL ARTICLE
Atena Shiva, Parisa Soltani, Amirhossein Moaddabi, Rezvan Yazdian, Majid Saeedi, Zohreh Mozoun, Atefe Esfandpour, Carlo Rengo, Parastoo Namdar, Gianrico Spagnuolo
INTRODUCTION: Folinic acid and botulinum toxin A have shown promising results in wound healing in different studies. This study aimed to compare the effects of these approaches on wound healing after simulating cleft lip surgery in rats. METHODS: In this experimental animal study, after creating lip defects, 30 rats were randomly divided into three groups and received normal saline (CTL), botulinum toxin A (BOT), and folinic acid (FOL). Biopsy from the skin wounds was performed after 14- and 28-days...
March 9, 2024: Orthodontics & Craniofacial Research
https://read.qxmd.com/read/38459564/cd146-cafs-promote-progression-of-endometrial-cancer-by-inducing-angiogenesis-and-vasculogenic-mimicry-via-il-10-jak1-stat3-pathway
#29
JOURNAL ARTICLE
Zhicheng Yu, Qian Zhang, Sitian Wei, Yang Zhang, Ting Zhou, Qi Zhang, Rui Shi, Dmitry Zinovkin, Zahidul Islam Pranjol, Jun Zhang, Hongbo Wang
Heterogeneous cancer-associated fibroblasts (CAFs) play important roles in cancer progression. However, the specific biological functions and regulatory mechanisms involved in endometrial cancer have yet to be elucidated. We aimed to explore the potential mechanisms of heterogeneous CAFs in promoting endometrial cancer progression. The presence of melanoma cell adhesion molecule (MCAM; CD146) positive CAFs was confirmed by tissue multi-immunofluorescence (mIF), and fluorescence activated cell sorting (FACS)...
March 8, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38458750/function-of-mast-cell-and-bile-cholangiocarcinoma-interplay-in-cholangiocarcinoma-microenvironment
#30
JOURNAL ARTICLE
Anda Shi, Zengli Liu, Zhongqi Fan, Kangshuai Li, Xingkai Liu, Yongchang Tang, Jiaming Hu, Xingyong Li, Lizhuang Shu, Liming Zhao, Lingling Huang, Zhiyue Zhang, Guoyue Lv, Zongli Zhang, Yunfei Xu
OBJECTIVE: The correlation between cholangiocarcinoma (CCA) progression and bile is rarely studied. Here, we aimed to identify differential metabolites in benign and malignant bile ducts and elucidate the generation, function and degradation of bile metabolites. DESIGN: Differential metabolites in the bile from CCA and benign biliary stenosis were identified by metabonomics. Biliary molecules able to induce mast cell (MC) degranulation were revealed by in vitro and in vivo experiments, including liquid chromatography-mass spectrometry (MS)/MS and bioluminescence resonance energy transfer assays...
March 8, 2024: Gut
https://read.qxmd.com/read/38455762/dynamic-interactions-in-the-tumor-niche-how-the-cross-talk-between-cafs-and-the-tumor-microenvironment-impacts-resistance-to-therapy
#31
REVIEW
Oliwia Piwocka, Igor Piotrowski, Wiktoria M Suchorska, Katarzyna Kulcenty
The tumor microenvironment (TME) is a complex ecosystem of cells, signaling molecules, and extracellular matrix components that profoundly influence cancer progression. Among the key players in the TME, cancer-associated fibroblasts (CAFs) have gained increasing attention for their diverse and influential roles. CAFs are activated fibroblasts found abundantly within the TME of various cancer types. CAFs contribute significantly to tumor progression by promoting angiogenesis, remodeling the extracellular matrix, and modulating immune cell infiltration...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38453252/assessing-the-efficacy-of-curcumin-loaded-alginate-hydrogel-on-skin-wound-healing-a-gene-expression-analysis
#32
JOURNAL ARTICLE
Sepehr Zamani, Majid Salehi, Arian Ehterami, Mh Busra Fauzi, Ghasem Abbaszadeh-Goudarzi
Skin tissue engineering has gained significant attention as a promising alternative to traditional treatments for skin injuries. In this study, we developed 3D hydrogel-based scaffolds, Alginate, incorporating different concentrations of Curcumin and evaluated their properties, including morphology, swelling behavior, weight loss, as well as hemo- and cytocompatibility. Furthermore, we investigated the therapeutic potential of Alginate hydrogel containing different amounts of Curcumin using an in vitro wound healing model...
March 7, 2024: Journal of Biomaterials Applications
https://read.qxmd.com/read/38442406/3d-printing-of-alginate-chitosan-based-scaffold-empowered-by-tyrosol-loaded-niosome-for-wound-healing-applications-in-vitro-and-in-vivo-performances
#33
JOURNAL ARTICLE
Farzaneh Mahmoudi Beram, Saba Naeimaei Ali, Ghazal Mesbahian, Fatemeh Pashizeh, Mohammadhosein Keshvadi, Farzaneh Mashayekhi, Behnoosh Khodadadi, Zahra Bashiri, Alaa Moeinzadeh, Niloufar Rezaei, Saina Namazifard, Nikoo Hossein-Khannazer, Mohammad Tavakkoli Yaraki
This study introduces a tyrosol-loaded niosome integrated into a chitosan-alginate scaffold (Nio-Tyro@CS-AL), employing advanced electrospinning and 3D printing techniques for wound healing applications. The niosomes, measuring 185.40 ± 6.40 nm with a polydispersity index of 0.168 ± 0.012, encapsulated tyrosol with an efficiency of 77.54 ± 1.25%. The scaffold's microsized porous structure (600-900 μm) enhances water absorption, promoting cell adhesion, migration, and proliferation. Mechanical property assessments revealed the scaffold's enhanced resilience, with niosomes increasing the compressive strength, modulus, and strain to failure, indicative of its suitability for wound healing...
March 5, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38442213/hydrogel-loaded-with-peptide-containing-nanocomplexes-symphonic-cooperation-of-photothermal-antimicrobial-nanoparticles-and-prohealing-peptides-for-the-treatment-of-infected-wounds
#34
JOURNAL ARTICLE
Qiuye Jia, Zhe Fu, Yuansheng Li, Zijian Kang, Yutong Wu, Zeqiong Ru, Ying Peng, Yubin Huang, Yonglu Luo, Wanghongyu Li, Yiran Hu, Xiaohan Sun, Junyuan Wang, Ziwei Deng, Chunyun Wu, Ying Wang, Xinwang Yang
Current treatment for chronic infectious wounds is limited due to severe drug resistance in certain bacteria. Therefore, the development of new composite hydrogels with nonantibiotic antibacterial and pro-wound repair is important. Here, we present a photothermal antibacterial composite hydrogel fabricated with a coating of Fe2+ cross-linked carboxymethyl chitosan (FeCMCS) following the incorporation of melanin nanoparticles (MNPs) and the CyRL-QN15 peptide. Various physical and photothermal properties of the hydrogel were characterized...
March 5, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38441826/dynamic-alterations-in-m2-macrophage-subtypes-enhance-flap-expansion-efficiency-and-tissue-regeneration
#35
JOURNAL ARTICLE
Xiangyue Wang, Mingyu Zhao, Qianwen Wang, Jiaqi Wang, Tailing Wang
Dilatation of soft skin tissue is a common surgical procedure in plastic surgery. M2 macrophages play a critical role in reducing inflammation, promoting epithelial and vascular endothelial cell proliferation, enhancing collagen synthesis in fibroblasts, and orchestrating extracellular matrix remodelling by promoting angiogenesis, epithelialisation, and fibrosis. Macrophages improve flap survival by promoting microangiogenesis and collagen remodelling. However, the role of macrophages in flap expansion has not yet been investigated...
March 5, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38435816/fibroblasts-and-endothelial-cells-interplay-drives-hypertrophic-scar-formation-insights-from-in-vitro-and-in-vivo-models
#36
JOURNAL ARTICLE
Yaxin Tan, Mengde Zhang, Yi Kong, Fanliang Zhang, Yuzhen Wang, Yuyan Huang, Wei Song, Zhao Li, Linhao Hou, Liting Liang, Xu Guo, Qinghua Liu, Yu Feng, Chao Zhang, Xiaobing Fu, Sha Huang
Hypertrophic scar formation is influenced by the intricate interplay between fibroblasts and endothelial cells. In this study, we investigated this relationship using in vitro and in vivo models. Clinical observations revealed distinct morphological changes and increased vascularity at pathological scar sites. Further analysis using OCTA, immunohistochemistry, and immunofluorescence confirmed the involvement of angiogenesis in scar formation. Our indirect co-culture systems demonstrated that endothelial cells enhance the proliferation and migration of fibroblasts through the secretion of cytokines including VEGF, PDGF, bFGF, and TGF-β...
March 2024: Bioengineering & Translational Medicine
https://read.qxmd.com/read/38434034/transplantation-of-induced-pluripotent-stem-cells-derived-cardiomyocytes-combined-with-modified-taohong-siwu-decoction-improved-heart-repair-after-myocardial-infarction
#37
JOURNAL ARTICLE
Zhi-Rong Luo, Wan-Ting Meng, Han Li, Yu Wang, Ya-Chao Wang, Yue Zhao, Ping-Ping Lu, Yuan Yuan, Wei Huang, Hai-Dong Guo
OBJECTIVE: This study aimed to study whether modified Taohong Siwu decoction (MTHSWD) combined with human induced pluripotent stem cells-derived cardiomyocytes (iPS-CMs) transplantation can promote cardiac function in myocardial infarction (MI) nude mouse model and explore its possible mechanism. METHODS: The MI mouse model was established by the ligation of left anterior descending coronary artery. After 4 weeks of gavage of MTHSWD combined with iPS-CMs transplantation, the changes in heart function of mice were examined by echocardiography...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38432579/effects-of-andiroba-oil-carapa-guianensis-aublet-on-the-immune-system-in-inflammation-and-wound-healing-a-scoping-review
#38
REVIEW
Aimê Stefany Alves da Fonseca, Isolda de Souza Monteiro, Carolina Ramos Dos Santos, Marcella Lemos Brettas Carneiro, Samuel Silva Morais, Paula Lauane Araújo, Thamis Fernandes Santana, Graziella Anselmo Joanitti
ETHNOPHARMACOLOGICAL RELEVANCE: Andiroba seed oil (Carapa guianensis Aubl.) is widely used by traditional populations in tropical countries, especially in the Brazilian Amazon, because of its anti-inflammatory, antirheumatic, antiseptic, healing and antipyretic properties, among others, which makes it useful for the treatment, mainly, of skin afflictions and wounds. AIM OF THE STUDY: To describe the modulation of the immune system by andiroba oil (Carapa guianensis Aubl...
March 1, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38428092/development-of-pluripotent-stem-cell-derived-epidermal-organoids-that-generate-effective-extracellular-vesicles-in-skin-regeneration
#39
JOURNAL ARTICLE
Sojung Kwak, Cho Lok Song, Jinhyuk Lee, Sungyeon Kim, Seungyoon Nam, Young-Jun Park, Jungwoon Lee
Cellular skin substitutes such as epidermal constructs have been developed for various applications, including wound healing and skin regeneration. These cellular models are mostly derived from primary cells such as keratinocytes and fibroblasts in a two-dimensional (2D) state, and further development of three-dimensional (3D) cultured organoids is needed to provide insight into the in vivo epidermal phenotype and physiology. Here, we report the development of epidermal organoids (EpiOs) generated from induced pluripotent stem cells (iPSCs) as a novel epidermal construct and its application as a source of secreted biomolecules recovered by extracellular vesicles (EVs) that can be utilized for cell-free therapy of regenerative medicine...
February 23, 2024: Biomaterials
https://read.qxmd.com/read/38424240/assessing-the-fate-and-contribution-of-foxd1-expressing-embryonic-precursors-and-their-progeny-in-palatal-development-homeostasis-and-excisional-repair
#40
JOURNAL ARTICLE
Georgia Nikoloudaki, Douglas W Hamilton
Oral mucosal tissues heal rapidly with minimal scarring, although palatal mucosa can be associated with excessive fibrosis in response to injury. Investigations on the balance between neovascularization and tissue repair suggests regulation of angiogenesis is an important determinant of repair versus scarring. Associated with pericyte mediated fibrosis in kidney injury, FoxD1 is implicated in growth centres during cranio-facial development, although which cell lineages are derived from these embryonic populations in development and in adult animals is unknown...
February 29, 2024: Scientific Reports
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