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https://www.readbyqxmd.com/read/28448670/molecular-mechanisms-underlying-the-filtration-bleb-maintaining-effects-of-suberoylanilide-hydroxamic-acid-saha
#1
Akiko Futakuchi, Toshihiro Inoue, Tomokazu Fujimoto, Utako Kuroda, Miyuki Inoue-Mochita, Eri Takahashi, Saori Ohira, Hidenobu Tanihara
Purpose: Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts. Methods: Human conjunctival fibroblasts (HConFs) were pretreated with SAHA before treatment with TGF-β2. Microarray-based screening was used to investigate the gene expression profiles...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28447570/peptide-modified-chitosan-hydrogel-accelerates-skin-wound-healing-by-promoting-fibroblast-proliferation-migration-and-secretion
#2
Xionglin Chen, Min Zhang, Shixuan Chen, Xueer Wang, Zhihui Tian, Yinghua Chen, Pengcheng Xu, Lei Zhang, Lu Zhang, Lin Zhang
Skin wound healing is a complicated process that involves a variety of cells and cytokines. Fibroblasts play an important role in this process and participate in transformation into myofibroblasts, the synthesis of extracellular matrix and fibers, and the secretion of a variety of growth factors. This study assessed the effects of peptide SIKVAV (Ser-Ile-Lys-Val-Ala-Val)-modified chitosan hydrogels on skin wound healing. We investigated the capability of peptide SIKVAV to promote cell proliferation and migration, the synthesis of collagen and the secretion of a variety of growth factors using fibroblasts in vitro...
April 26, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28442752/zika-virus-infection-reprograms-global-transcription-of-host-cells-to-allow-sustained-infection
#3
Shashi Kant Tiwari, Jason Dang, Yue Qin, Gianluigi Lichinchi, Vikas Bansal, Tariq M Rana
Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection. To identify novel antiviral targets and to elucidate the mechanisms by which ZIKV exploits the host cell machinery to support sustained replication, we analyzed the transcriptomic landscape of human microglia, fibroblast, embryonic kidney and monocyte-derived macrophage cell lines before and after ZIKV infection...
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442143/polypropylene-mesh-seeded-with-fibroblasts-a-new-approach-for-the-repair-of-abdominal-wall-defects-in-rats
#4
A Mohsina, Naveen Kumar, A K Sharma, Sameer Shrivastava, Dayamon D Mathew, V Remya, Sonal, S K Maiti, Kiranjeet Singh, K P Singh
PURPOSE: The purpose of study was to develop bioengineered scaffolds by seeding primary mouse embryo fibroblast cells (p-MEF) on polypropylene mesh and to test its efficacy for the repair of abdominal wall defects in rats. METHODS: The study was conducted on 18 clinically healthy adult Wistar rats of either sex. The animals were randomly divided into two equal groups having nine animals in each group. In both the groups a 20mm×20mm size full thickness muscle defect was created under xylazine and ketamine anesthesia in the mid-ventral abdominal wall...
April 17, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28441391/apigenin-inhibits-tnf%C3%AE-il-1%C3%AE-induced-ccl2-release-through-ikbk-epsilon-signaling-in-mda-mb-231-human-breast-cancer-cells
#5
David Bauer, Natalie Redmon, Elizabeth Mazzio, Karam F Soliman
Mortality associated with breast cancer is attributable to aggressive metastasis, to which TNFα plays a central orchestrating role. TNFα acts on breast tumor TNF receptors evoking the release of chemotactic proteins (e.g. MCP-1/CCL2). These proteins direct inward infiltration/migration of tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs), T-regulatory cells (Tregs), T helper IL-17-producing cells (Th17s), metastasis-associated macrophages (MAMs) and cancer-associated fibroblasts (CAFs)...
2017: PloS One
https://www.readbyqxmd.com/read/28440285/ionizing-radiation-abrogates-the-pro-tumorigenic-capacity-of-cancer-associated-fibroblasts-co-implanted-in-xenografts
#6
Maria Tunset Grinde, Jørg Vik, Ketil André Camilio, Inigo Martinez-Zubiaurre, Turid Hellevik
Cancer-associated fibroblasts (CAFs) are abundantly present in solid tumors and affect tumorigenesis and therapeutic responses. In the context of clinical radiotherapy, the impact of irradiated CAFs to treatment outcomes is largely unexplored. Aiming at improving radiotherapy efficacy, we have here explored the effect of radiation on the inherent pro-tumorigenic capacity of CAFs in animals. Ionizing radiation was delivered to cultured CAFs as single-high or fractionated doses. Tumor development was compared in mice receiving A549 lung tumor cells admixed with irradiated or control CAFs...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439487/modified-rice-bran-hemicellulose-inhibits-vascular-endothelial-growth-factor-induced-angiogenesis-in-vitro-via-vegfr2-and-its-downstream-signaling-pathways
#7
Xia Zhu, Aya Okubo, Naoki Igari, Kentaro Ninomiya, Yukari Egashira
Angiogenesis is implicated in diverse pathological conditions such as cancer, rheumatoid arthritis, psoriasis, atherosclerosis, and retinal neovascularization. In the present study, we investigated the effects of modified rice bran hemicellulose (MRBH), a water-soluble hemicellulose preparation from rice bran treated with shiitake enzymes, on vascular endothelial growth factor (VEGF)-induced angiogenesis in vitro and its mechanism. We found that MRBH significantly inhibited VEGF-induced tube formation in human umbilical vein endothelial cells (HUVECs) co-cultured with human dermal fibroblasts...
2017: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/28436224/multi-functional-hydrogels-prepared-by-dual-ion-crosslinking-for-chronic-wound-healing
#8
Yonghui Li, Yan Han, Xiaoya Wang, Jinliang Peng, Yuhong Xu, Jiang Chang
The creation of moist environment and promotion of blood vessel formation are critical for wound healing. Sodium alginate (SA) hydrogel, which has good biocompatibility and is able to provide moist environment, has been widely used as wound dressing. However, it lacks antibacterial and bio-activities, which would facilitate chronic wound healing. On the basis of gelation characteristics of SA and the bioactive hardystonite (HS) bioceramic, we designed a unique bioactive injectable composite hydrogel through double ion-crosslinking, in which divalent ions such as Ca2+ and Zn2+ function as crosslinkers, Zn2+ also functions as antibacterial component and nutrition for wound healing, and Si ions play the key role in determining the bioactivity of the hydrogel...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28433654/high-molecular-weight-fgf2-isoforms-demonstrate-canonical-receptor-mediated-activity-and-support-human-embryonic-stem-cell-self-renewal
#9
Denis Kole, Alexandra Grella, David Dolivo, Lucia Shumaker, William Hermans, Tanja Dominko
Basic fibroblast growth factor (FGF2) is a highly pleiotropic member of a large family of growth factors with a broad range of activities, including mitogenesis and angiogenesis (Ornitz et al., 1996; Zhang et al., 2006), and it is known to be essential for maintenance of balance between survival, proliferation, and self-renewal in human pluripotent stem cells (Eiselleova et al., 2009; Zoumaro-Djayoon et al., 2011). A single FGF2 transcript can be translated into five FGF2 protein isoforms, an 18kDa low molecular weight (LMW) isoform and four larger high molecular weight (HMW) isoforms (Arese et al...
April 18, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28423685/tumor-fibroblast-interactions-stimulate-tumor-vascularization-by-enhancing-cytokine-driven-production-of-mmp9-by-tumor-cells
#10
Michelle Limoge, Alfiya Safina, Amy Beattie, Lauren Kapus, Alexander M Truskinovsky, Andrei V Bakin
Advance-stage breast carcinomas include significant amounts of fibroblasts and infiltrating immune cells which have been implicated in tumor growth, recurrence, and response to therapy. The present study investigated the contribution of fibroblasts to tumor growth using direct tumor-fibroblast co-cultures and tumor xenograft models. Our findings revealed that fibroblasts enhance breast carcinoma growth by promoting the tumor vasculature via the MMP9-dependent mechanism. In tumor-fibroblast co-cultures, fibroblasts increased expression of TGF-β, TNF, and IL-1β cytokines in tumor cells...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423625/inhibition-activity-of-a-disulfide-stabilized-diabody-against-basic-fibroblast-growth-factor-in-lung-cancer
#11
Yaxiong Cai, Shuange Yao, Jiangchuan Zhong, Jinxia Zhang, Haowu Jiang, Yanrui Deng, Ning Deng
The over-expression of basic fibroblast growth factor (bFGF) plays a crucial role in the development, invasion and metastasis of lung cancer. Therefore, neutralizing antibodies against bFGF may inhibit the growth of lung cancer. In this study, a Disulfide-stabilized diabody (ds-Diabody) against bFGF was constructed by site-directed mutation and overlap extension PCR (SOE-PCR) at the position of VH44 and VL100 in the scFv. The ds-Diabody was constructed and expressed in Pichia pastoris. We found that the ds-Diabody against bFGF could efficiently suppress the proliferation, migration and invasion of human lung cancer A549 cells in vitro...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419941/pamam-generation-4-incorporated-gelatin-3d-matrix-as-an-improved-dermal-substitute-for-skin-tissue-engineering
#12
Somnath Maji, Tarun Agarwal, Tapas Kumar Maiti
The study explored the prospects of PAMAM (generation 4) applicability in gelatin based scaffolds for skin tissue engineering. The effect of PAMAM on physico-chemical and biological characteristics of gelatin scaffolds was evaluated. Gelatin scaffolds (with/without PAMAM) were prepared by lyophilization, chemically crosslinked by glutaraldehyde and characterized for their morphology (pore size), chemical features (bond nature), water adsorption, biodegradation and biological compatibility. The study demonstrated that addition of PAMAM did not significantly alter the pore size distribution or porosity of the scaffolds...
April 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28415472/supercritical-carbon-dioxide-extracted-extracellular-matrix-material-from-adipose-tissue
#13
Jun Kit Wang, Baiwen Luo, Vipra Guneta, Liang Li, Selin Ee Min Foo, Yun Dai, Timothy Thatt Yang Tan, Nguan Soon Tan, Cleo Choong, Marcus Thien Chong Wong
Adipose tissue is a rich source of extracellular matrix (ECM) material that can be isolated by delipidating and decellularizing the tissue. However, the current delipidation and decellularization methods either involve tedious and lengthy processes or require toxic chemicals, which may result in the elimination of vital proteins and growth factors found in the ECM. Hence, an alternative delipidation and decellularization method for adipose tissue was developed using supercritical carbon dioxide (SC-CO2) that eliminates the need of any harsh chemicals and also reduces the amount of processing time required...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413025/biochemical-and-biological-attributes-of-matrix-metalloproteinases
#14
Ning Cui, Min Hu, Raouf A Khalil
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are involved in the degradation of various proteins in the extracellular matrix (ECM). Typically, MMPs have a propeptide sequence, a catalytic metalloproteinase domain with catalytic zinc, a hinge region or linker peptide, and a hemopexin domain. MMPs are commonly classified on the basis of their substrates and the organization of their structural domains into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28412748/tumor-necrosis-factor-receptor-2-akt-and-erk-signaling-pathways-contribute-to-the-switch-from-fibroblasts-to-cafs-by-progranulin-in-microenvironment-of-colorectal-cancer
#15
Linlin Wang, Dong Yang, Jing Tian, Aiqin Gao, Yihang Shen, Xia Ren, Xia Li, Guosheng Jiang, Taotao Dong
Cancer associated fibroblasts (CAFs) are a crucial cellular component in tumor microenvironment and could promote tumor progression. CAFs are usually derived from resident fibroblasts, which undergoing an activated process stimulated by tumor cells. However, the agents and mechanism driving this switch have not yet been elucidated. Progranulin (PGRN), a well acknowledged secreted glycoprotein, could promote proliferation and angiogenesis of colorectal cancer (CRC) cells, and high expression of PGRN correlated with patient poor prognosis...
February 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408960/molecular-characterization-and-function-of-tenomodulin-a-marker-of-tendons-and-ligaments-that-integrate-musculoskeletal-components
#16
REVIEW
Chisa Shukunami, Yuki Yoshimoto, Aki Takimoto, Hiroshi Yamashita, Yuji Hiraki
Tendons and ligaments are dense fibrous bands of connective tissue that integrate musculoskeletal components in vertebrates. Tendons connect skeletal muscles to the bone and function as mechanical force transmitters, whereas ligaments bind adjacent bones together to stabilize joints and restrict unwanted joint movement. Fibroblasts residing in tendons and ligaments are called tenocytes and ligamentocytes, respectively. Tenomodulin (Tnmd) is a type II transmembrane glycoprotein that is expressed at high levels in tenocytes and ligamentocytes, and is also present in periodontal ligament cells and tendon stem/progenitor cells...
November 2016: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28396222/activin-b-regulates-adipose-derived-mesenchymal-stem-cells-to-promote-skin-wound-healing-via-activation-of-the-mapk-signaling-pathway
#17
Lei Zhang, Pengcheng Xu, Xueer Wang, Min Zhang, Yuan Yan, Yinghua Chen, Lu Zhang, Lin Zhang
Adipose-derived stem cells (ADSCs) are multipotent stromal cells that can differentiate into a variety of cell types, including skin cells, and they can provide an abundant source of cells for skin tissue engineering and skin wound healing. The purpose of this study is to explore the therapeutic effects of activin B in combination with ADSCs and the possible signaling mechanism. In this study, we found that activin B was able to promote ADSC migration by inducing actin stress fiber formation in vitro. In vivo, activin B in combination with ADSCs was capable of enhancing α-SMA expression and wound closure...
April 8, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28395533/the-influence-of-occupational-chronic-lead-exposure-on-the-levels-of-selected-pro-inflammatory-cytokines-and-angiogenic-factors
#18
A Machoń-Grecka, M Dobrakowski, M Boroń, G Lisowska, A Kasperczyk, S Kasperczyk
The aim of the study was to determine the effect of occupational exposure to lead on the blood levels of pro-inflammatory cytokines and selected factors that influence angiogenesis. The study population was divided into two groups. The first group consisted of 56 male workers chronically exposed to lead. The second group (control) was comprised of 24 male administrative workers. The serum levels of interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) were significantly higher in the group of workers chronically exposed to lead compared to control values by 38%, 68%, and 57%, respectively...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28395342/stimulatory-effects-of-fibroblast-growth-factor-2-on-proliferation-and-migration-of-uterine-luminal-epithelial-cells-during-early-pregnancy%C3%A2-%C3%A2
#19
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Fibroblast growth factor 2 (FGF2) is a mitogen that induces proliferation, differentiation, and migration of cells, as well as angiogenesis and carcinogenesis via autocrine or paracrine actions. Fibroblast growth factor 2 expression is abundant in porcine conceptuses and endometrium during the estrous cycle and peri-implantation period of pregnancy. However, its intracellular actions in uterine epithelial cells have not been reported. The results of this study indicated abundant expression of FGFR1 and FGFR2 predominantly in uterine luminal and glandular epithelia during early pregnancy and that their expression decreased with increasing parity of the sows...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28394354/oncogenic-mct-1-activation-promotes-yy1-egfr-mnsod-signaling-and-tumor-progression
#20
H-Y Tseng, Y-A Chen, J Jen, P-C Shen, L-M Chen, T-D Lin, Y-C Wang, H-L Hsu
Tumor cells often produce high levels of reactive oxygen species (ROS) and display an increased ROS scavenging system. However, the molecular mechanism that balances antioxidative and oxidative stress in cancer cells is unclear. Here, we determined that oncogenic multiple copies in T-cell malignancy 1 (MCT-1) activity promotes the generation of intracellular ROS and mitochondrial superoxide. Overexpression of MCT-1 suppresses p53 accumulation but elevates the manganese-dependent superoxide dismutase (MnSOD) level via the YY1-EGFR signaling cascade, which protects cells against oxidative damage...
April 10, 2017: Oncogenesis
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