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https://www.readbyqxmd.com/read/27914252/synthesis-of-copper-containing-bioactive-glass-nanoparticles-using-a-modified-st%C3%A3-ber-method-for-biomedical-applications
#1
Kai Zheng, Xinyi Dai, Miao Lu, Norbert Hüser, Nicola Taccardi, Aldo R Boccaccini
Copper (Cu)-containing bioactive glasses (BGs) are attracting attention for bone regeneration and wound healing since they have bone-bonding capability and potential osteogenesis and angiogenesis properties. In this study, highly dispersed and spherical Cu-containing bioactive glass nanoparticles (Cu-BGNs) were successfully synthesized via a modified Stöber method. The content of incorporated Cu in the particles could be tailored by adjusting the amount of the added Cu precursor, a procedure that had no significant effects on the morphological and structural characteristics of the nanoparticles...
November 15, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27914030/active-compounds-extracted-from-extra-virgin-olive-oil-counteract-mesothelial-to-mesenchymal-transition-of-peritoneal-mesothelium-cells-exposed-to-conventional-peritoneal-dialysate-in-vitro-and-in-vivo-evidences
#2
S Lupinacci, G Toteda, D Vizza, A Perri, C Benincasa, A Mollica, A La Russa, P Gigliotti, F Leone, D Lofaro, M Bonofiglio, E Perri, R Bonofiglio
During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive thickening and angiogenesis of the peritoneal membrane associated with PD. In this study we tested, in vitro and in vivo, the ability of active compounds extracted from extra virgin olive oil (AC-EVOO) to counteract the mesothelial-to-mesenchymal transition process (MMT) observed in mesothelial cells chronically exposed to the conventional peritoneal dialysate (DL)...
December 2, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27911414/isolation-and-culture-of-primary-endothelial-cells-from-canine-arteries-and-veins
#3
Loes A Oosterhoff, Hedwig S Kruitwagen, Bart Spee, Frank G van Steenbeek
Cardiovascular disease is studied in both human and veterinary medicine. Endothelial cells have been used extensively as an in vitro model to study vasculogenesis, (tumor) angiogenesis, and atherosclerosis. The current standard for in vitro research on human endothelial cells (ECs) is the use of Human Umbilical Vein Endothelial Cells (HUVECs) and Human Umbilical Artery Endothelial Cells (HUAECs). For canine endothelial research, only one cell line (CnAOEC) is available, which is derived from canine aortic endothelium...
November 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27907001/multifactorial-optimizations-for-directing-endothelial-fate-from-stem-cells
#4
Drew E Glaser, William S Turner, Nicole Madfis, Lian Wong, Jose Zamora, Nicholas White, Samuel Reyes, Andrew B Burns, Ajay Gopinathan, Kara E McCloskey
Embryonic stem cells (ESC) and induced pluripotent stem (iPS) cells are attractive in vitro models of vascular development, therapeutic angiogenesis, and tissue engineering. However, distinct ESC and iPS cell lines respond differentially to the same microenvironmental factors. Developing improved/optimized differentiation methodologies tailored/applicable in a number of distinct iPS and ESC lines remains a challenge in the field. Currently published methods for deriving endothelial cells (EC) robustly generate high numbers of endothlelial progenitor cells (EPC) within a week, but their maturation to definitive EC is much more difficult, taking up to 2 months and requiring additional purification...
2016: PloS One
https://www.readbyqxmd.com/read/27906035/extracellular-vesicles-in-the-pathogenesis-of-rheumatoid-arthritis-and-osteoarthritis
#5
REVIEW
Joseph Withrow, Cameron Murphy, Yutao Liu, Monte Hunter, Sadanand Fulzele, Mark W Hamrick
Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population. Extracellular vesicles (EVs), including exosomes and microvesicles, are now recognized to play important roles in cell-to-cell communication by transporting various proteins, microRNAs (miRNAs), and mRNAs. EV-derived proteins and miRNAs impact cell viability and cell differentiation, and are likely to play a prominent role in the pathophysiology of both OA and RA. Some of the processes by which these membrane-bound vesicles can alter joint tissue include extracellular matrix degradation, cell-to-cell communication, modulation of inflammation, angiogenesis, and antigen presentation...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27903483/therapeutic-benefits-and-adverse-effects-of-combined-pro-angiogenic-gene-therapy-in-mouse-critical-leg-ischemia
#6
Benoît Lebas, Julien Galley, Edith Renaud-Gabardos, Françoise Pujol, Françoise Lenfant, Barbara Garmy-Susini, Xavier Chaufour, Anne-Catherine Prats
OBJECTIVE: Critical leg ischemia (CLI) represents the ultimate stage of peripheral arterial disease. Despite current surgery advances, patients with CLI have limited therapeutic options. Therapeutic angiogenesis thus appears as a powerful approach, aiming to stimulate vessel formation by angiogenic molecules administration. In this context, combined gene therapy has proved the most efficient. The present study aims to compare, in a preclinical mouse model, the therapeutic benefit of a combination of two angiogenic factors FGF2 (fibroblast growth factor 2) and Cyr61 using plasmid and viral vectors, able to generate short or long-term transgene expression in the leg, respectively...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27902486/ed-b-fibronectin-expression-is-a-marker-of-epithelial-mesenchymal-transition-in-translational-oncology
#7
Iacopo Petrini, Serena Barachini, Vittoria Carnicelli, Sara Galimberti, Letizia Modeo, Roberto Boni, Martina Sollini, Paola Anna Erba
Fibronectin is a component of the extracellular matrix that links collagen fibers to integrins on the cell's surface. The splicing isoforms, containing the ED-B domain, are not expressed in adult tissues but only in tumor stroma or during embryonic development. Fibroblasts and endothelial cells express ED-B fibronectin during angiogenesis. Also cancer cells can synthetize ED-B fibronectin, but its function in tumor growth needs to be further elucidated.We evaluated the expression of ED-B fibronectin in prostate cancer cell lines: PC3 and DU145...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27895888/in-situ-formation-of-poly-vinyl-alcohol-heparin-hydrogels-for-mild-encapsulation-and-prolonged-release-of-basic-fibroblast-growth-factor-and-vascular-endothelial-growth-factor
#8
Justine J Roberts, Brooke L Farrugia, Rylie A Green, Jelena Rnjak-Kovacina, Penny J Martens
Heparin-based hydrogels are attractive for controlled growth factor delivery, due to the native ability of heparin to bind and stabilize growth factors. Basic fibroblast growth factor and vascular endothelial growth factor are heparin-binding growth factors that synergistically enhance angiogenesis. Mild, in situ encapsulation of both basic fibroblast growth factor and vascular endothelial growth factor and subsequent bioactive dual release has not been demonstrated from heparin-crosslinked hydrogels, and the combined long-term delivery of both growth factors from biomaterials is still a major challenge...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/27887936/prokineticin-2-plays-a-pivotal-role-in-psoriasis
#9
Xiaoqin He, Chuanbin Shen, Qiumin Lu, Jiong Li, Yuquan Wei, Li He, Ruizhen Bai, Jie Zheng, Ning Luan, Zhiye Zhang, Mingqiang Rong, Ren Lai
Psoriasis is histologically characterized by keratinocytes (KC) hyperproliferation, inflammation, and increased angiogenesis, but the pathological factor responsible for these symptoms is unknown. Here, a neuroendocrine peptide (prokineticin 2, PK2), is highly expressed in human and mouse psoriatic skins but no significant change in other autoimmune diseases, suggesting that PK2 is a psoriasis-specific factor. Bacterial products significantly up-regulated PK2, implying that infection induces PK2 over-expression...
October 19, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27868332/the-transcriptional-responses-of-cultured-wound-cells-to-the-excretions-and-secretions-of-medicinal-lucilia-sericata-larvae
#10
Priscila Dauros Singorenko, Roseanne Rosario, John A Windsor, Anthony R Phillips, Cherie Blenkiron
Maggots, through their excretions and secretions (ES), promote wound healing by removing necrotic tissue, counter bacterial infection, and activate wound associated cells. We investigated the effects of a physiological dose of maggot ES on four wound-associated cell types in vitro with Affymetrix gene expression arrays; keratinocytes, endothelial cells, fibroblasts and monocytes. Keratinocytes showed the fewest (n=5; p<0.05, fold-change ±2) and smallest fold-changes (up to 2.32x) in gene expression and conversely THP1 monocytes had the most (n=233) and greatest magnitude (up to 44...
November 21, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27864565/targeting-non-canonical-nuclear-factor-%C3%AE%C2%BAb-signalling-attenuates-neovascularization-in-a-novel-3d-model-of-rheumatoid-arthritis-synovial-angiogenesis
#11
Chrissta X Maracle, Paulina Kucharzewska, Boy Helder, Corine van der Horst, Pedro Correa de Sampaio, Ae-Ri Noort, Katinka van Zoest, Arjan W Griffioen, Henric Olsson, Sander W Tas
OBJECTIVE: Angiogenesis is crucial in RA disease progression. Lymphotoxin β receptor (LTβR)-induced activation of the non-canonical nuclear factor-κB (NF-κB) pathway via NF-κB-inducing kinase (NIK) has been implicated in this process. Consequently, inhibition of this pathway may hold therapeutic potential in RA. We describe a novel three-dimensional (3D) model of synovial angiogenesis incorporating endothelial cells (ECs), RA fibroblast-like synoviocytes (RAFLSs) and RA synovial fluid (RASF) to further investigate the contributions of NF-κB in this process...
November 17, 2016: Rheumatology
https://www.readbyqxmd.com/read/27863477/keratin-19-as-a-key-molecule-in-progression-of-human-hepatocellular-carcinomas-through-invasion-and-angiogenesis
#12
Masato Takano, Keiji Shimada, Tomomi Fujii, Kohei Morita, Maiko Takeda, Yoshiyuki Nakajima, Akitaka Nonomura, Noboru Konishi, Chiho Obayashi
BACKGROUND: Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC remain unclear. We attempted to clarify whether K19 directly affects cell survival and invasiveness in association with cellular senescence or epithelial-mesenchymal transition (EMT) in K19-positive HCC. METHODS: K19 expression was analysed in 136 HCC surgical specimens...
November 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27863391/nordihydroguaiaretic-acid-impairs-prostate-cancer-cell-migration-and-tumor-metastasis-by-suppressing-neuropilin-1
#13
Xin Li, Shengjun Fan, Xueyang Pan, Yilixiati Xiaokaiti, Jianhui Duan, Yundi Shi, Yan Pan, Lu Tie, Xin Wang, Yuhua Li, Xuejun Li
Tumor metastasis is a major cause leading to the deaths of cancer patients. Nordihydroguaiaretic acid (NDGA) is a natural product that has been demonstrated to show therapeutic values in multiple diseases. In this study, we report that NDGA can inhibit cell migration and tumor metastasis via a novel mechanism. NDGA suppresses NRP1 function by downregulating its expression, which leads to attenuated cell motility, cell adhesion to ECM and FAK signaling in cancer cells. Moreover, due to its cross-cell type activity on NRP1 suppression, NDGA also impairs angiogenesis function of endothelial cells and fibronectin assembly by fibroblasts, both of which are critical to promote metastasis...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27853265/human-cd133-renal-progenitor-cells-induce-erythropoietin-production-and-limit-fibrosis-after-acute-tubular-injury
#14
Shikhar Aggarwal, Cristina Grange, Corinne Iampietro, Giovanni Camussi, Benedetta Bussolati
Persistent alterations of the renal tissue due to maladaptive repair characterize the outcome of acute kidney injury (AKI), despite a clinical recovery. Acute damage may also limit the renal production of erythropoietin, with impairment of the hemopoietic response to ischemia and possible lack of its reno-protective action. We aimed to evaluate the effect of a cell therapy using human CD133(+) renal progenitor cells on maladaptive repair and fibrosis following AKI in a model of glycerol-induced rhabdomyolysis...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853183/exosomes-derived-from-embryonal-and-alveolar-rhabdomyosarcoma-carry-differential-mirna-cargo-and-promote-invasion-of-recipient-fibroblasts
#15
Sandra E Ghayad, Ghina Rammal, Farah Ghamloush, Hussein Basma, Rihab Nasr, Mona Diab-Assaf, Claude Chelala, Raya Saab
Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive clinical behavior. Exosomes are small membranous vesicles secreted into body fluids by multiple cell types, including tumor cells, and have been implicated in metastatic progression through paracrine signaling. We characterized exosomes secreted by a panel of 5 RMS cell lines. Expression array analysis showed that, for both fusion-positive and fusion-negative cells, exosome miRNA clustered well together and to a higher extent than cellular miRNA...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852013/modulation-of-cell-attachment-proliferation-and-angiogenesis-by-decellularized-dehydrated-human-amniotic-membrane-in-in-vitro-models
#16
Xuan Guo, Aleksandr Kaplunovsky, Raihana Zaka, Chuan Wang, Hemlata Rana, Jeffrey Turner, Qian Ye, Ivana Djuretic, Joseph Gleason, Vladimir Jankovic, Janice M Smiell, Mohit Bhatia, Wolfgang Hofgartner, Robert Hariri
BACKGROUND: Decellularized, dehydrated human amniotic membrane (DDHAM) is an extracellular matrix devoid of cells, cell debris, and growth factors. This study examines the effect of cell attachment to the DDHAM and the induced cellular responses. MATERIALS AND METHODS: The cell types employed in this study were human dermal fibroblasts (HDF), human epithelial keratinocytes (HEK), and human dermal microvascular endothelial cells (HDMEC), all of which play critical roles in the wound healing process...
October 24, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27832497/adhesion-gpcrs-in-tumorigenesis
#17
Gabriela Aust, Dan Zhu, Erwin G Van Meir, Lei Xu
Alterations in the homeostasis of several adhesion GPCRs (aGPCRs) have been observed in cancer. The main cellular functions regulated by aGPCRs are cell adhesion, migration, polarity, and guidance, which are all highly relevant to tumor cell biology. Expression of aGPCRs can be induced, increased, decreased, or silenced in the tumor or in stromal cells of the tumor microenvironment, including fibroblasts and endothelial and/or immune cells. For example, ADGRE5 (CD97) and ADGRG1 (GPR56) show increased expression in many cancers, and initial functional studies suggest that both are relevant for tumor cell migration and invasion...
2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27829391/esophageal-squamous-cell-carcinoma-invasion-is-inhibited-by-activin-a-in-acvrib-positive-cells
#18
Holli A Loomans, Shanna A Arnold, Laura L Quast, Claudia D Andl
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a global public health issue, as it is the eighth most common cancer worldwide. The mechanisms behind ESCC invasion and progression are still poorly understood, and warrant further investigation into these processes and their drivers. In recent years, the ligand Activin A has been implicated as a player in the progression of a number of cancers. The objective of this study was to investigate the role of Activin A signaling in ESCC...
November 9, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27826254/elastin-in-the-liver
#19
REVIEW
Jiří Kanta
A characteristic feature of liver cirrhosis is the accumulation of large amounts of connective tissue with the prevailing content of type I collagen. Elastin is a minor connective tissue component in normal liver but it is actively synthesized by hepatic stellate cells and portal fibroblasts in diseased liver. The accumulation of elastic fibers in later stages of liver fibrosis may contribute to the decreasing reversibility of the disease with advancing time. Elastin is formed by polymerization of tropoelastin monomers...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27825419/biological-characteristics-of-cluster-of-differentiation-147-and-its-relationship-with-tumour
#20
Cen Gao, Chao-Hui Lu, Jie Chen
Cluster of differentiation 147(CD147)/extracellular matrix metalloproteinase inducer (EMMPRIN) is a widely distributed transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is highly enriched on the surface of malignant tumour cells. A major function of CD147 is to stimulate matrix metalloproteinase production in stromal fibroblasts and endothelial cells. CD147 promotes growth,invasion,metastasis,and glycolysis of malignant cells,induces angiogenesis,multidrug resistance,and anoikis resistance,and inhibits starvation-induced autophagy et al...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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