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https://www.readbyqxmd.com/read/28238838/polyphenols-in-combination-with-%C3%AE-cyclodextrin-can-inhibit-and-disaggregate-%C3%AE-synuclein-amyloids-under-cell-mimicking-conditions-a-promising-therapeutic-alternative
#1
Saurabh Gautam, Sandip Karmakar, Radhika Batra, Pankaj Sharma, Prashant Pradhan, Jasdeep Singh, Bishwajit Kundu, Pramit K Chowdhury
Parkinson's disease is characterized by the presence of insoluble and neurotoxic aggregates (amyloid fibrils) of an intrinsically disordered protein α-synuclein. In this study we have examined the effects of four naturally occurring polyphenols in combination with β-cyclodextrin (β-CD) on the aggregation of α-synuclein in the presence of macromolecular crowding agents. Our results reveal that even at sub-stoichiometric concentrations of the individual components, the polyphenol-β-CD combination(s) not only inhibited the aggregation of the proteins but was also effective in disaggregating preformed fibrils...
February 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28236357/psychometric-properties-of-the-alabama-parenting-questionnaire-adapted-to-families-of-chilean-preschoolers
#2
Félix Cova, Claudio Bustos, Paulina Rincón, David L Streiner, Pamela Grandón, Sandra Saldivia, Carolina Inostroza, Gisela Contreras
The Alabama Parenting Questionnaire (APQ) is a well-known tool to assess empirically identified aspects of positive and negative parenting practices. This study evaluates the psychometric properties of an adapted version of the APQ for its use with parents of children between 2 and 6 years of age in Chile. The participants were 557 parents of children aged 2 to 6 years. A confirmatory factor analysis showed that the best fit was obtained by a four-factor model (positive reinforcement, parental involvement, inconsistency of disciplinary practices, and punitive practices)...
February 25, 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28236013/needlescopic-sleeve-gastrectomy-pushing-the-boundaries-of-the-standard-technique
#3
Marcelo Loureiro, Abdulah Sultan, Mohannad Alhaddad, Hatem Mostafa, David Nocca, Marius Nedelcu, Walled Buhaimed
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is the most common bariatric surgery performed worldwide. Improvements in LSG have been suggested to achieve better weight loss or to lessen the complications rates. We propose a change in the standard technique to privilege the use of thinner instruments, the needlescopic sleeve gastrectomy (NSG). METHODS: A 40-year-old female, BMI 40, with no previous abdominal surgery was selected for a NSG. She was placed in a semi-sitting position with the surgeon standing between the legs...
February 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28230747/dynamic-method-of-neutral-axis-position-determination-and-damage-identification-with-distributed-long-gauge-fbg-sensors
#4
Yongsheng Tang, Zhongdao Ren
The neutral axis position (NAP) is a key parameter of a flexural member for structure design and safety evaluation. The accuracy of NAP measurement based on traditional methods does not satisfy the demands of structural performance assessment especially under live traffic loads. In this paper, a new method to determine NAP is developed by using modal macro-strain (MMS). In the proposed method, macro-strain is first measured with long-gauge Fiber Bragg Grating (FBG) sensors; then the MMS is generated from the measured macro-strain with Fourier transform; and finally the neutral axis position coefficient (NAPC) is determined from the MMS and the neutral axis depth is calculated with NAPC...
February 20, 2017: Sensors
https://www.readbyqxmd.com/read/28230405/getting-what-you-expect-future-self-views-predict-the-valence-of-life-events
#5
Peggy Voss, Anna E Kornadt, Klaus Rothermund
Views on aging have been shown to predict the occurrence of events related to physical health in previous studies. Extending these findings, we investigated the relation between aging-related future self-views and life events in a longitudinal study across a range of different life domains. Participants (N = 593, age range 30-80 years at t1) completed a survey at 2 measurement occasions that were separated by a 4-year interval (t1: 2009, t2: 2013), providing information on domain-specific future self-views as well as on life events that had occurred in the respective domains in-between the 2 measurement occasions...
March 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28229477/-why-not-you-discourses-of-widening-access-on-uk-medical-school-websites
#6
Kirsty Alexander, Tania Fahey Palma, Sandra Nicholson, Jennifer Cleland
CONTEXT: In the UK, applications to medicine from those in lower socio-economic groups remain low despite significant investments of time, interest and resources in widening access (WA) to medicine. This suggests that medical schools' core messages about WA may be working to embed or further reinforce marginalisation, rather than to combat this. Our objective was to investigate how the value of WA is communicated by UK medical schools through their websites, and how this may create expectations regarding who is 'suitable' for medicine...
February 22, 2017: Medical Education
https://www.readbyqxmd.com/read/28226803/closed-loop-afferent-electrical-stimulation-for-recovery-of-hand-function-in-individuals-with-motor-incomplete-spinal-injury-early-clinical-results
#7
Christopher J Schildt, Sarah H Thomas, Elizabeth S Powell, Lumy Sawaki, Sridhar Sunderam, Christopher J Schildt, Sarah H Thomas, Elizabeth S Powell, Lumy Sawaki, Sridhar Sunderam, Lumy Sawaki, Christopher J Schildt, Elizabeth S Powell, Sarah H Thomas, Sridhar Sunderam
Afferent electrical stimulation is known to augment the effect of rehabilitative therapy through use-dependent cortical plasticity. Experiments pairing transcranial magnetic stimulation (TMS) with peripheral nerve stimulation (PNS) have shown a timing-dependent effect on motor evoked potential (MEP) amplitude suggesting that PNS applied in closed-loop (CL) mode could augment this effect through positive reinforcement. We present early results from a clinical trial in which an EEG brain-machine interface (BMI) was used to apply PNS to two subjects in response to motor intent detected from sensorimotor cortex in a cue-driven hand grip task...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226432/reinforcement-learning-for-stabilizing-an-inverted-pendulum-naturally-leads-to-intermittent-feedback-control-as-in-human-quiet-standing
#8
Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura, Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura, Ken Kiyono, Pietro Morasso, Kenjiro Michimoto, Yasushi Kobayashi, Yasuyuki Suzuki, Taishin Nomura
Intermittent feedback control for stabilizing human upright stance is a promising strategy, alternative to the standard time-continuous stiffness control. Here we show that such an intermittent controller can be established naturally through reinforcement learning. To this end, we used a single inverted pendulum model of the upright posture and a very simple reward function that gives a certain amount of punishments when the inverted pendulum falls or changes its position in the state space. We found that the acquired feedback controller exhibits hallmarks of the intermittent feedback control strategy, namely the action of the feedback controller is switched-off intermittently when the state of the pendulum is located near the stable manifold of the unstable saddle-type upright equilibrium of the inverted pendulum with no active control: this action provides an opportunity to exploit transiently converging dynamics toward the unstable upright position with no help of the active feedback control...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223940/reconsideration-of-serial-visual-reversal-learning-in-octopus-octopus-vulgaris-from-a-methodological-perspective
#9
Alexander Bublitz, Severine R Weinhold, Sophia Strobel, Guido Dehnhardt, Frederike D Hanke
Octopuses (Octopus vulgaris) are generally considered to possess extraordinary cognitive abilities including the ability to successfully perform in a serial reversal learning task. During reversal learning, an animal is presented with a discrimination problem and after reaching a learning criterion, the signs of the stimuli are reversed: the former positive becomes the negative stimulus and vice versa. If an animal improves its performance over reversals, it is ascribed advanced cognitive abilities. Reversal learning has been tested in octopus in a number of studies...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28221985/role-of-food-handlers-in-norovirus-outbreaks-in-london-and-south-east-england-2013-to-2015
#10
C Rumble, S Addiman, S Balasegaram, K Chima, D Ready, J Heard, E Alexander
Outbreaks caused by norovirus infection are common and occur throughout the year. Outbreaks can be related to food outlets either through a contaminated food source or an infected food handler. Both asymptomatic and symptomatic food handlers are potentially implicated in outbreaks, but evidence of transmission is limited. To understand potential food handler transmission in outbreak scenarios, epidemiological and microbiological data on possible and confirmed norovirus outbreaks reported in London and South East England in a 2-year period were reviewed...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221761/ultrasmall-superbright-neodymium-upconversion-nanoparticles-via-energy-migration-manipulation-and-lattice-modification-808-nm-activated-drug-release
#11
Yan Zhang, Zhongzheng Yu, Jingqiu Li, Yanxiao Ao, Jingwen Xue, Zhiping Zeng, Xiangliang Yang, Timothy Thatt Yang Tan
Nd(3+)-sensitized upconversion nanoparticles are amongst the most promising emerging fluorescent nanotransducers. They are activated by 808 nm irradiation, which features merits such as limited tissue overheating and deeper penetration depth, hence attractive for diagnostic and therapeutic applications. Recent studies indicate that ultrasmall nanoparticles (<10 nm) are potentially more suitable for clinical application due to their favorable biodistribution and safety profiles. However, upconversion nanoparticles in the sub-10 nm range suffer from poor luminescence due to their ultrasmall size and greater proportion of lattice defects...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28221674/effects-of-visitor-numbers-on-captive-european-red-squirrels-sciurus-vulgaris-and-impacts-on-visitor-experience
#12
Eleanor E Woolway, Anne E Goodenough
Visitors to zoological collections can have substantial effects on captive animals that vary according to species, enclosure design, visitor proximity, and husbandry methods. One particularly intense form of visitor interaction occurs in immersive exhibits such as walk-through enclosures. Such enclosures are increasingly common but effects on animal behavior are currently understudied. Here, the behavior of captive European red squirrels (Sciurus vulgaris) is studied in relation to visitor numbers in a walk-through enclosure...
February 21, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28219015/the-expectations-of-antenatal-screening-and-experiences-of-the-first-trimester-screening-scan
#13
Maarit Nykänen, Katri Vehviläinen-Julkunen, Reija Klemetti
AIM: to describe the expectations to and knowledge of antenatal screening of expecting parents, and their experiences concerning the first-trimester screening scan. DESIGN: survey study with a consecutive sampling method. SETTING: two hospital districts in Finland, namely the capital area and Eastern Finland. Together these two districts include the six different municipal units in which the first-trimester screening scans discussed in the study were done during spring 2015...
February 15, 2017: Midwifery
https://www.readbyqxmd.com/read/28218962/survey-of-neonatal-resuscitation-practices-showed-post-training-improvements-but-need-to-reinforce-preterm-management-monitoring-and-adrenaline-use
#14
Montserrat Izquierdo, Martín Iriondo, César Ruiz, Gonzalo Zeballos, Miguel Sánchez, Eva Gonzalez, Máximo Vento, Marta Thió
AIM: Neonatal resuscitation surveys have showed practice variations between countries, centres and levels of care. We evaluated delivery room practices after a nationwide neonatal resuscitation training programme focused on non-tertiary centres. METHODS: A 2012 survey sent to all Spanish hospitals handling deliveries covered staff availability and training, equipment and practices in the delivery room and during transfers to neonatal intensive care units. The results from 98 centres that had completed a previous survey in 2007 were analysed by levels of care...
February 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28216068/stages-of-dysfunctional-decision-making-in-addiction
#15
REVIEW
Antonio Verdejo-Garcia, Trevor T-J Chong, Julie C Stout, Murat Yücel, Edythe D London
Drug use is a choice with immediate positive outcomes, but long-term negative consequences. Thus, the repeated use of drugs in the face of negative consequences suggests dysfunction in the cognitive mechanisms underpinning decision-making. This cognitive dysfunction can be mapped into three stages: the formation of preferences involving valuation of decision options; choice implementation including motivation, self-regulation and inhibitory processes; and feedback processing implicating reinforcement learning...
February 16, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28215377/healthy-empowered-youth-a-positive-youth-development-program-for-native-youth
#16
Stephanie N Craig Rushing, Nichole L Hildebrandt, Carol J Grimes, Amanda J Rowsell, Benjamin C Christensen, William E Lambert
INTRODUCTION: During 2010-2012, Oregon Health & Science University's Prevention Research Center, a Northwest Tribe, and the Northwest Portland Area Indian Health Board, collaborated to evaluate the Healthy & Empowered Youth Project, a school- and community-based positive youth development program for American Indian and Alaska Native high school students. METHODS: The Native STAND (Students Together Against Negative Decisions) curriculum was enhanced with hands-on learning activities in media design to engage students in sexual and reproductive health topics covered by the curriculum...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28213557/tension-pneumocephalus-induced-by-high-flow-nasal-cannula-ventilation-in-a-neonate
#17
Alicia Iglesias-Deus, Alejandro Pérez-Muñuzuri, Olalla López-Suárez, Pilar Crespo, Maria-Luz Couce
The use of high-flow nasal cannula (HFNC) therapy as respiratory support for preterm infants has increased rapidly worldwide. The evidence available for the use of HFNC is as an alternative to nasal continuous positive airway pressure (CPAP) and in particular to prevent postextubation failure. We report a case of tension pneumocephalus in a preterm infant as a complication during HFNC ventilation. Significant neurological impairment was detected and support was eventually withdrawn. Few cases of pneumocephalus as a complication of positive airway pressure have been reported in the neonatal period, and they all have been related to CPAP...
March 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28211890/local-melting-to-design-strong-and-plastically-deformable-bulk-metallic-glass-composites
#18
Yue-Sheng Qin, Xiao-Liang Han, Kai-Kai Song, Yu-Hao Tian, Chuan-Xiao Peng, Li Wang, Bao-An Sun, Gang Wang, Ivan Kaban, Jürgen Eckert
Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a big challenge for materials engineering. In this work, we proposed a technique of instantaneously and locally arc-melting BMG plate to artificially induce the precipitation of B2 crystals in the glassy matrix and then to tune mechanical properties...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210747/extent-of-field-change-in-colorectal-cancers-with-braf-mutation
#19
Aaron Poh, Heidi Sian Ying Chang, Kok Yang Tan, Xin Xiu Sam, Avery Khoo, Shoa Nian Choo, Min En Nga, Wei Keat Wan
INTRODUCTION: Sporadic colorectal cancers with BRAF mutations constitute two distinct subgroups of colorectal cancers. Recent studies have linked the presence of the BRAF mutation to a familial inheritance pattern. This was a proof-of-concept study that aimed to examine: (a) the extent of field change in sporadic colorectal cancers with BRAF mutation; and (b) the extent of resection margins required and the pattern of DNA mismatch repair protein loss in these tumours. METHODS: Eight microsatellite instability-high (MSI-H) tumours with positive BRAF mutation from an existing histopathological database were selected for BRAF mutation and mismatch repair protein analysis...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28208686/identification-of-autophagy-related-genes-and-their-regulatory-mirnas-associated-with-celiac-disease-in-children
#20
Sergio Comincini, Federico Manai, Cristina Meazza, Sara Pagani, Carolina Martinelli, Noemi Pasqua, Gloria Pelizzo, Marco Biggiogera, Mauro Bozzola
Celiac disease (CD) is a severe genetic autoimmune disorder, affecting about one in 100 people, where the ingestion of gluten leads to damage in the small intestine. Diagnosing CD is quite complex and requires blood tests and intestinal biopsy examinations. Controversy exists regarding making the diagnosis without biopsy, due to the large spectrum of manifesting symptoms; furthermore, small-intestinal gastroscopy examinations have a relatively complex management in the pediatric population. To identify novel molecular markers useful to increase the sensitivity and specificity in the diagnosis of pediatric CD patients, the expression levels of two key autophagy executor genes (ATG7 and BECN1) and their regulatory validated miRNAs (miR-17 and miR-30a, respectively) were analyzed by relative quantitative real-time-PCR on a cohort of confirmed CD patients compared to age-related controls...
February 12, 2017: International Journal of Molecular Sciences
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