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https://www.readbyqxmd.com/read/28327794/seasonality-of-sand-flies-diptera-psychodidae-and-leishmania-dna-detection-in-vector-species-in-an-area-with-endemic-visceral-leishmaniasis
#1
Lara Saraiva, Camila Gonçalves Leite, Ana Cristina Vianna Mariano da Rocha Lima, Luiz Otávio Alves de Carvalho, Agnes Antônia Sampaio Pereira, Jerônimo Marteleto Nunes Rugani, Felipe Dutra Rego, Célia Maria Ferreira Gontijo, José Dilermando Andrade
BACKGROUND: Leishmaniases are a serious health problem in southeast Brazil, including the city of Belo Horizonte (BH), Minas Gerais state (MG), where there are high rates of incidence and mortality due to visceral leishmaniases. BH is divided into nine sanitary districts (SD) of which one, the Venda Nova SD, was selected for this study because it has high rates of positivity for canine leishmaniasis and high incidence of human leishmaniasis. OBJECTIVES: This study aimed to survey the sand fly fauna in Venda Nova SD from August 2011 to July 2013 and perform a descriptive analysis of the vector population...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28326026/pre-clinical-studies-with-d-penicillamine-as-a-novel-pharmacological-strategy-to-treat-alcoholism-updated-evidences
#2
REVIEW
Alejandro Orrico, Lucía Martí-Prats, María J Cano-Cebrián, Luis Granero, Ana Polache, Teodoro Zornoza
Ethanol, as other drugs of abuse, is able to activate the ventral tegmental area dopamine (VTA-DA) neurons leading to positively motivational alcohol-seeking behavior and use, and, ultimately to ethanol addiction. In the last decades, the involvement of brain-derived acetaldehyde (ACD) in the ethanol actions in the mesolimbic pathway has been widely demonstrated. Consistent published results have provided a mechanistic support to the use of ACD inactivating agents to block the motivational and reinforcing properties of ethanol...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28324204/tibial-nerve-neuropathy-following-medial-opening-wedge-high-tibial-osteotomy-case-report-of-a-rare-technical-complication
#3
Young-Soo Shin, Hyun-Bo Sim, Jung-Ro Yoon
A 63-year-old woman developed tibial nerve injury caused by an overlong K wire and 4.5-mm cortical lag screw through the first distal hole below the osteotomy during medial opening-wedge high tibial osteotomy (HTO), leading to a lack of sensation on the sole of the foot with no disturbances in motor functions. The temporary lag screw in the first distal hole below the osteotomy is often inserted by an excessive length in order to compress the potentially fractured opposite cortex. By doing so, posterior neurovascular structures including the tibial nerve and the popliteal vessels can be injured...
March 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28322980/role-of-perineuronal-nets-in-the-anterior-dorsal-lateral-hypothalamic-area-in-the-acquisition-of-cocaine-induced-conditioned-place-preference-and-self-administration
#4
Jordan M Blacktop, Ryan P Todd, Barbara A Sorg
Addiction involves drug-induced neuroplasticity in the circuitry of motivated behavior, which includes the medial forebrain bundle and the lateral hypothalamic area. Emerging at the forefront of neuroplasticity regulation are specialized extracellular matrix (ECM) structures that form perineuronal nets (PNNs) around certain neurons, mainly parvalbumin positive (PV(+)), fast-spiking interneurons (FSINs), making them a promising target for the regulation of drug-induced neuroplasticity. Despite the emerging significance of PNNs in drug-induced neuroplasticity and the well-established role of the lateral hypothalamic area (LHA) in reward, reinforcement, and motivation, very little is known about how PNN-expressing neurons control drug-seeking behavior...
March 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28320350/views-of-somali-women-and-men-on-the-use-of-faith-based-messages-promoting-breast-and-cervical-cancer-screening-for-somali-women-a-focus-group-study
#5
Rebekah Pratt, Sharif Mohamed, Wali Dirie, Nimo Ahmed, Michael VanKeulen, Huda Ahmed, Nancy Raymond, Kola Okuyemi
BACKGROUND: Screening rates for breast and cervical cancer for Muslim women in the United States are low, particularly for first-generation immigrants. Interpretations of the Muslim faith represent some of the barriers for breast and cervical cancer screening. Working to understand how faith influences breast and cervical screening for Somali women, and working with the community to identify and utilize faith-based assets for promoting screening, may lead to life-saving changes in screening behaviors...
March 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28320174/etiological-agents-of-viral-meningitis-in-children-from-a-dengue-endemic-area-southeast-region-of-brazil
#6
Danilo B de Oliveira, Talitah M Candiani, Ana Paula M Franco-Luiz, Gabriel M F Almeida, Jônatas S Abrahão, Maria Rios, Roney S Coimbra, Erna G Kroon
Meningitis is a disease with a global distribution that constitutes a worldwide burden, with viruses as the primary etiologic agents. The range of viral meningitis severity depends mainly on age, immune status and etiological agent. The aim of this work was to investigate the suspected cases of viral meningitis using molecular techniques to confirm the viral infection. The diagnosed virus was correlated with clinical findings and cytochemical parameters in cerebrospinal liquid (CSF) of patients. CSF of 70 children with the presumptive diagnosis of viral meningitis was analyzed by real time PCR (qPCR)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319992/organizational-and-community-factors-associated-with-magnet-status-of-u-s-hospitals
#7
Teresa Wai Chi Tai, Sherry I Bame
The Magnet Recognition Program for healthcare organizations promotes excellence in nursing services and professional practices. However, organizational and community characteristics that contribute to the adoption of Magnet status remain unexplained. Investigating organizational and community factors will help determine systematic structural and contextual dimensions of Magnet hospitals previously shown to be more cost-effective in comparison with non-Magnet hospitals. Using the baseline 2005 database of all Magnet hospitals in the United States, the authors selected a matched sample to determine key organizational and community characteristics associated with Magnet adoption while controlling for regional and local factors...
January 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28319588/physical-activity-and-global-self-worth-in-a-longitudinal-study-of-children
#8
Hudson Reddon, David Meyre, John Cairney
PURPOSE: Physical activity is associated with an array of physical and mental health benefits among children and adolescents. The development of self-worth/self-esteem has been proposed as a mechanism to explain the mental health benefits derived from physical activity. Despite several studies that have analyzed the association between physical activity and self-worth, the results have been inconsistent. It is also uncertain how related physical health measures, such as sedentary behaviour, body composition and fitness influence the relationship between physical activity and self-worth over time...
March 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28318341/caregivers-advice-and-children-s-bystander-behaviors-during-bullying-incidents
#9
Stevie N Grassetti, Julie A Hubbard, Marissa A Smith, Megan K Bookhout, Lauren E Swift, Michael J Gawrysiak
Many bullying prevention programs take a bystander approach, which encourages children to intervene when they are bystanders to bullying incidents. Little is known about how caregivers' advice to children might promote or undermine the positive bystander behaviors targeted by these programs. Accordingly, the aim of the current study was to investigate relations between caregivers' advice and children's bystander behavior during bullying situations. Participants were 106 racially/ethnically diverse 4th- and 5th-grade students (M age = 10...
March 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28317247/establishing-the-pathways-and-indications-for-performing-isotope-bone-scans-in-newly-diagnosed-intermediate-risk-localised-prostate-cancer-results-from-a-large-contemporaneous-cohort
#10
Gokul Vignesh KandaSwamy, Adam Bennett, Krishna Narahari, Owen Hughes, John Rees, Howard Kynaston
OBJECTIVE: To establish the pattern of isotope bone scan (BS) positivity in a large contemporaneous cohort of newly diagnosed localised prostate cancer (PCa) patients and compare with the European Association of Urology (EAU) guidelines. BACKGROUND: Imaging guidelines and clinical practice of using BS to stage newly diagnosed patients with intermediate risk (IR) localised PCa are not uniform in the literature. PATIENTS AND METHODS: All newly diagnosed PCa patients were discussed in a specialist multidisciplinary team (sMDT) meeting and were prospectively entered in a database...
March 20, 2017: BJU International
https://www.readbyqxmd.com/read/28316581/reciprocal-relations-between-work-related-authenticity-and-intrinsic-motivation-work-ability-and-depressivity-a-two-wave-study
#11
Astrid I Emmerich, Thomas Rigotti
This study investigates the role of context-specific authenticity at work for work-related outcomes (intrinsic motivation, work ability) and depressivity. Furthermore reciprocal relations between work-related authenticity and healthy psychological functioning are investigated. Longitudinal data from 1,243 employees from 63 subsidiaries of a non-profit organization in the social sector were analyzed using multilevel structural equation modeling. Work-related authenticity at T1 predicted work ability and depressivity, but not intrinsic motivation at T2, about 6 months later...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28316564/functional-circuitry-effect-of-ventral-tegmental-area-deep-brain-stimulation-imaging-and-neurochemical-evidence-of-mesocortical-and-mesolimbic-pathway-modulation
#12
Megan L Settell, Paola Testini, Shinho Cho, Jannifer H Lee, Charles D Blaha, Hang J Jo, Kendall H Lee, Hoon-Ki Min
Background: The ventral tegmental area (VTA), containing mesolimbic and mesocortical dopaminergic neurons, is implicated in processes involving reward, addiction, reinforcement, and learning, which are associated with a variety of neuropsychiatric disorders. Electrical stimulation of the VTA or the medial forebrain bundle and its projection target the nucleus accumbens (NAc) is reported to improve depressive symptoms in patients affected by severe, treatment-resistant major depressive disorder (MDD) and depressive-like symptoms in animal models of depression...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28301764/reward-processing-neuroeconomics-and-psychopathology
#13
David H Zald, Michael T Treadway
Abnormal reward processing is a prominent transdiagnostic feature of psychopathology. The present review provides a framework for considering the different aspects of reward processing and their assessment, and highlights recent insights from the field of neuroeconomics that may aid in understanding these processes. Although altered reward processing in psychopathology has often been treated as a general hypo- or hyperresponsivity to reward, increasing data indicate that a comprehensive understanding of reward dysfunction requires characterization within more specific reward-processing domains, including subjective valuation, discounting, hedonics, reward anticipation and facilitation, and reinforcement learning...
March 15, 2017: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/28301189/differential-effects-of-neural-inactivation-of-the-dorsolateral-striatum-on-response-and-latent-extinction
#14
Jarid Goodman, Amanda Gabriele, Mark G Packard
The present study examined the role of the dorsolateral striatum (DLS) in extinction behavior. Male Long-Evans rats were initially trained on the straight alley maze, in which they were reinforced to traverse a straight runway and retrieve food reward at the opposite end of the maze. After initial acquisition, animals were given extinction training using 1 of 2 distinct protocols: response extinction or latent extinction. For response extinction, the animal was released from the same starting position and had the opportunity to perform the originally reinforced approach response to the goal end of the maze, which no longer contained food...
April 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28300967/burden-of-cancer-mortality-and-differences-attributable-to-demographic-aging-and-risk-factors-in-argentina-1986-2011
#15
Sonia Alejandra Pou, Natalia Tumas, Julia Becaria Coquet, Camila Niclis, María Dolores Román, María Del Pilar Díaz
The world faces an aging population that implies a large number of people affected with chronic diseases. Argentina has reached an advanced stage of demographic transition and presents a comparatively high rate of cancer mortality within Latin America. The objectives of this study were to examine cancer mortality trends in the province of Córdoba, Argentina, between 1986 and 2011, and to analyze the differences attributable to risk variations and demographic changes. Longitudinal series of age-standardized mortality rates for overall, breast and prostate cancers were modeled by Joinpoint regression to estimate the annual percent change...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28298993/the-effect-of-short-polyethylene-fiber-with-different-weight-percentages-on-diametral-tensile-strength-of-conventional-and-resin-modified-glass-ionomer-cements
#16
Farahnaz Sharafeddin, Seyed-Ali Ghaboos, Zahra Jowkar
BACKGROUND: The aim of this study was to investigate the effect of polyethylene fiber on diametral tensile strength of conventional and resin modified glass ionomer cements. MATERIAL AND METHODS: 60 specimens in 6 groups (n=10) were prepared. In group 1 conventional glass ionomer (Fuji GC) and in group 2 resin modified glass ionomer (Fuji LC) were as control groups. In group 3 and 4 conventional glass ionomers mixed with short polyethylene fibers in proportion of 1 wt% and 3 wt%, respectively...
March 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28298887/automated-operant-conditioning-in-the-mouse-home-cage
#17
Nikolas A Francis, Patrick O Kanold
Recent advances in neuroimaging and genetics have made mice an advantageous animal model for studying the neurophysiology of sensation, cognition, and locomotion. A key benefit of mice is that they provide a large population of test subjects for behavioral screening. Reflex-based assays of hearing in mice, such as the widely used acoustic startle response, are less accurate than operant conditioning in measuring auditory processing. To date, however, there are few cost-effective options for scalable operant conditioning systems...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28298209/implementation-of-evidence-informed-practice-through-central-network-actors-a-case-study-of-three-public-health-units-in-canada
#18
Reza Yousefi Nooraie, Alexandra Marin, Robert Hanneman, Lynne Lohfeld, Maureen Dobbins
BACKGROUND: Workforce development is an important aspect of evidence-informed decision making (EIDM) interventions. The social position of individuals in formal and informal social networks, and the relevance of formal roles in relation to EIDM are important factors identifying key EIDM players in public health organizations. We assessed the role of central actors in information sharing networks in promoting the adoption of EIDM by the staff of three public health units in Canada, over a two-year period during which an organization-wide intervention was implemented...
March 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28294133/the-gabab-positive-allosteric-modulator-adx71441-attenuates-alcohol-self-administration-and-relapse-to-alcohol-seeking-in-rats
#19
Eric Augier, Russell S Dulman, Ruslan Damadzic, Andrew Pilling, J Paul Hamilton, Markus Heilig
GABAergic signaling is involved in modulating the reinforcing properties of alcohol, and GABAB receptors have been proposed as a potential target for clinical treatment of alcoholism. The orthosteric GABAB receptor agonist baclofen has been shown to suppress operant self-administration of alcohol in animals and alcohol use in alcohol dependent patients, but its utility is limited by a narrow therapeutic index. We tested the effects of ADX71441, a novel GABAB receptor positive allosteric modulator on alcohol-related behaviors in rats...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28293709/metabolic-perturbation-to-enhance-polyketide-and-nonribosomal-peptide-antibiotic-production-using-triclosan-and-ribosome-targeting-drugs
#20
Yukinori Tanaka, Masumi Izawa, Yoshikazu Hiraga, Yuya Misaki, Tomoko Watanabe, Kozo Ochi
Although transcriptional activation of pathwayspecific positive regulatory genes and/or biosynthetic genes is primarily important for enhancing secondary metabolite production, reinforcement of substrate supply, as represented by primary metabolites, is also effective. For example, partial inhibition of fatty acid synthesis with ARC2 (an analog of triclosan) was found to enhance polyketide antibiotic production. Here, we demonstrate that this approach is effective even for industrial high-producing strains, for example enhancing salinomycin production by 40%, reaching 30...
March 14, 2017: Applied Microbiology and Biotechnology
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