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https://www.readbyqxmd.com/read/28925963/on-the-role-of-processing-parameters-in-producing-recycled-aluminum-aa6061-based-metal-matrix-composite-mmc-alr-prepared-using-hot-press-forging-hpf-process
#1
Azlan Ahmad, Mohd Amri Lajis, Nur Kamilah Yusuf
Solid-state recycling, which involves the direct recycling of scrap metal into bulk material using severe plastic deformation, has emerged as a potential alternative to the conventional remelting and recycling techniques. Hot press forging has been identified as a sustainable direct recycling technique that has fewer steps and maintains excellent material performance. An experimental investigation was conducted to explore the hardness and density of a recycled aluminum-based metal matrix composite by varying operating temperature and holding time...
September 19, 2017: Materials
https://www.readbyqxmd.com/read/28924520/complete-remission-in-locally-advanced-breast-cancer-what-comprehensive-multi-modality-treatment-has-to-offer-in-sub-saharan-africa
#2
Gaurav Bhattacharya, Susan C Msadabwe-Chikuni, Roanne Segal, Omkar Inamdar, Catherine K Mwaba
Locally advanced breast cancer presents as a heterogeneous disease, but it is often best treated with aggressive combined modality therapy.  Commonly, it carries a more guarded prognosis. Given the above, it can be a particularly challenging entity to treat in resource-limited settings. We identify one such case with a relative lack of hormone receptor positivity in the sub-Saharan country of Zambia. Management of the disease was hampered by the challenges of resource constraints and communication gaps that are especially acute in low- to middle-income nations as compared to Western societies...
July 6, 2017: Curēus
https://www.readbyqxmd.com/read/28923857/metalnc9-facilitates-lung-cancer-metastasis-via-a-pgk1-activated-akt-mtor-pathway
#3
Ming Yao, Tao Yu, Ying-Jun Zhao, Zhixiang Hu, Jing Li, Dandan Chu, Jiwei Zhang, Zhe Li, Bing Chen, Xiao Zhang, Hongyu Pan, Shengli Li, Hechun Lin, Lei Liu, Mingxia Yan, Xianghuo He
Long non-coding RNAs participate in carcinogenesis and tumor progression in lung cancer. Here we report the identification of a lncRNA signature associated with metastasis of non-small cell lung cancer (NSCLC). In particular, elevated expression of LINC00963 (MetaLnc9) in human NSCLC specimens correlated with poor prognosis, promoted migration and invasion of NSCLC cells in vitro, and enhanced lung metastasis formation in vivo. Mechanistic investigations showed that MetaLnc9 interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in NSCLC cells, leading to activation of the oncogenic AKT/mTOR signaling pathway...
September 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28923360/when-theory-and-biology-differ-the-relationship-between-reward-prediction-errors-and-expectancy
#4
Chad C Williams, Cameron D Hassall, Robert Trska, Clay B Holroyd, Olave E Krigolson
Comparisons between expectations and outcomes are critical for learning. Termed prediction errors, the violations of expectancy that occur when outcomes differ from expectations are used to modify value and shape behaviour. In the present study, we examined how a wide range of expectancy violations impacted neural signals associated with feedback processing. Participants performed a time estimation task in which they had to guess the duration of one second while their electroencephalogram was recorded. In a key manipulation, we varied task difficulty across the experiment to create a range of different feedback expectancies - reward feedback was either very expected, expected, 50/50, unexpected, or very unexpected...
September 15, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28922943/differential-prevalence-of-antibodies-against-adeno-associated-virus-in-healthy-children-and-patients-with-mucopolysaccharidosis-iii-perspective-for-aav-mediated-gene-therapy
#5
Haiyan Fu, Aaron S Meadows, Ricardo J Pineda, Krista L Kunkler, Kristen V Truxal, Kim L McBride, Kevin Flanigan, Douglas M McCarty
Recombinant AAV vectors are promising gene therapy tools. However, pre-existing antibodies (Abs) to many useful AAV serotypes pose a critical challenge for the translation of gene therapies. As part of AAV gene therapy program for treating MPS III patients, we investigated the seroprevalence profiles of AAV1-9 and rh74 in MPS IIIA/IIIB patients and in healthy children. Using ELISA for αAAV-IgG, we observed significantly higher sero-prevalence for AAV1 and AAVrh74 in 2-7y-old MPS III patients than in healthy controls...
September 19, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28922262/sugar-in-infants-children-and-adolescents-a-position-paper-of-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-committee-on-nutrition
#6
Nataša Fidler Mis, Christian Braegger, Jiri Bronsky, Cristina Campoy, Magnus Domellöf, Nicholas D Embleton, Iva Hojsak, Jessie Hulst, Flavia Indrio, Alexandre Lapillonne, Walter Mihatsch, Christian Molgaard, Rakesh Vora, Mary Fewtrell
The consumption of sugars, particularly sugar-sweetened beverages (SSBs; beverages or drinks that contain added caloric sweeteners (i.e. sucrose, high-fructose corn syrup, fruit-juice concentrates), in European children and adolescents exceeds current recommendations. This is of concern because there is no nutritional requirement for free sugars, and infants have an innate preference for sweet taste, which may be modified and reinforced by pre- and postnatal exposures. Sugar containing beverages/free sugars increase the risk for overweight/obesity and dental caries, can result in poor nutrient supply and reduced dietary diversity and may be associated with increased risk of type 2 diabetes mellitus, cardiovascular risk, and other health effects...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28922002/behavioral-activation-strategies-for-major-depression-in-transdiagnostic-cognitive-behavioral-therapy-an-evidence-based-case-study
#7
Todd J Farchione, James F Boswell, Julianne G Wilner
Behavioral activation (BA) is a treatment approach that uses functional analysis and context-dependent strategies to enhance environmental positive reinforcement for adaptive, healthy behavior, and decrease behavioral avoidance. BA has gained considerable support for the treatment of depression and can be broadly applied across a wide range of settings and clinical populations. In this article, we provide a brief description of BA as a therapeutic behavioral strategy for depression and present a clinical case example illustrating the integration of BA with other components of a transdiagnostic cognitive-behavioral treatment for emotional disorders...
September 2017: Psychotherapy
https://www.readbyqxmd.com/read/28919072/assessment-of-nicotine-withdrawal-induced-changes-in-sucrose-preference-in-mice
#8
Y Alkhlaif, D Bagdas, A Jackson, A J Park, M I Damaj
Anhedonia, induced by nicotine withdrawal, may serve as an important affective sign that reinforces tobacco use and smoking relapse rates in humans. Animal models provide a way to investigate the underlying neurobiological factors involved in the decrease in responding for positive affective stimuli during nicotine withdrawal and may aid in drug development for nicotine dependence. Thus, we explored the use of the sucrose preference test to measure nicotine withdrawal-induced reduction in response for positive affective stimuli in mice...
September 15, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28917367/perceptions-of-hatha-yoga-amongst-persistently-depressed-individuals-enrolled-in-a-trial-of-yoga-for-depression
#9
Lisa A Uebelacker, Morganne Kraines, Monica K Broughton, Geoffrey Tremont, L Tom Gillette, Gary Epstein-Lubow, Ana M Abrantes, Cynthia Battle, Ivan W Miller
OBJECTIVES: To understand depressed individuals' experiences in a 10-week hatha yoga program. DESIGN: In a randomized controlled trial, participants were assigned to either 10 weeks of hatha yoga classes or a health education control group. This report includes responses from participants in yoga classes. At the start of classes, average depression symptom severity level was moderate. MAIN OUTCOME MEASURES: After 10 weeks of yoga classes, we asked participants (n=50) to provide written responses to open-ended questions about what they liked about classes, what they did not like or did not find helpful, and what they learned...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28917089/the-trehalose-specific-transporter-lpqy-sugabc-is-required-for-antimicrobial-and-anti-biofilm-activity-of-trehalose-analogues-in-mycobacterium-smegmatis
#10
Jeffrey M Wolber, Bailey L Urbanek, Lisa M Meints, Brent F Piligian, Irene C Lopez-Casillas, Kailey M Zochowski, Peter J Woodruff, Benjamin M Swarts
Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess distinctive pathways for synthesizing and utilizing the non-mammalian disaccharide trehalose. Trehalose metabolism is essential for mycobacterial viability and has been linked to in vitro biofilm formation, which may bear relevance to in vivo drug tolerance. Previous research has shown that some trehalose analogues bearing modifications at the 6-position inhibit growth of various mycobacterial species. In this work, 2-, 5-, and 6-position-modified trehalose analogues were synthesized using our previously reported one-step chemoenzymatic method and shown to inhibit growth and biofilm formation in the two-to three-digit micromolar range in Mycobacterium smegmatis...
August 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28913671/the-effect-of-educational-program-based-on-precede-model-in-promoting-prostate-cancer-screening-in-a-sample-of-iranian-men
#11
Ali Khani Jeihooni, Seyyed Mansour Kashfi, Mahmood Hatami, Abulqasim Avand, Mohammad-Rafi Bazrafshan
Prostate cancer is one of the most prevalent diseases among men. This study aimed to assess the effect of educational program based on Predisposing, Reinforcing, and Enabling Constructs in Educational/Environmental Diagnosis and Evaluation (PRECEDE) model in promoting prostate cancer screening in a sample of Iranian men. This is a quasi-experimental study carried out on 300 men aged 40 to 70 (the subjects 150 experimental and 150 control groups) in Shiraz City, Fars Province, Iran, in 2016. The participants of the intervention group attended training based on the PRECEDE model...
September 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28913380/questionable-word-choice-in-scientific-writing-in-orthopedic-surgery
#12
Casey M O'Connor, Mariano E Menendez, Kevin Hughes, David Ring
BACKGROUND: Given the strong influence of thoughts, emotions, and behaviors on musculoskeletal symptoms and limitations it's important that both scientific and lay writing use the most positive, hopeful, and adaptive words and concepts consistent with medical evidence. The use of words that might reinforce misconceptions about preference-sensitive conditions (particularly those associated with age) could increase symptoms and limitations and might also distract patients from the treatment preferences they would select when informed and at ease...
July 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28911327/negotiating-power-relations-gender-equality-and-collective-agency-are-village-health-committees-transformative-social-spaces-in-northern-india
#13
Kerry Scott, Asha S George, Steven A Harvey, Shinjini Mondal, Gupteswar Patel, Kabir Sheikh
BACKGROUND: Participatory health initiatives ideally support progressive social change and stronger collective agency for marginalized groups. However, this empowering potential is often limited by inequalities within communities and between communities and outside actors (i.e. government officials, policymakers). We examined how the participatory initiative of Village Health, Sanitation, and Nutrition Committees (VHSNCs) can enable and hinder the renegotiation of power in rural north India...
September 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28904288/alpha-pvp-induces-the-rewarding-effect-via-activating-dopaminergic-neuron
#14
Kyoko Hataoka, Asuka Kaizaki-Mitsumoto, Satoshi Numazawa
A synthetic cathinone, 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP), was occasionally found in the "bath salt" type of designer drugs, as an active ingredient. It has been reported that drivers who consumed α-PVP were in an excited state and incapable of controlling their behavior, causing traffic accidents. Despite its acute excitatory effects, there is no information on the psychological dependency elicited by α-PVP use. The purpose of the present study was to clarify whether the reward pathway is activated with repeated doses of α-PVP in experimental animals...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28902098/repair-of-the-thumb-ulnar-collateral-ligament-with-suture-tape-augmentation
#15
Anthony F De Giacomo, Steven S Shin
One of the most commonly injured structures of the thumb metacarpophalangeal (MCP) joint is the ulnar collateral ligament (UCL). An acute injury of this ligament is often amenable to primary repair. Despite the favorable outcomes of primary repair, the thumb is often restricted during initial healing of the ligament with immobilization and delayed rehabilitation. We present a novel technique to augment the repair of the UCL with suture tape to provide immediate biomechanical support and strength during the critical time of ligament healing...
September 8, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28898302/-belief-system-regarding-cannabis-its-use-and-consequences-users-versus-non-users-in-colombian-university-students
#16
Gonzalo Galván, Álvaro Sánchez-Carballo, Ileana Gómez-Morales, Oscar Humánez-Julio, Manuel Guerrero-Martelo, Francisco Vásquez De la Hoz
Descriptive and comparative study of cross-sectional that had as objective to evaluate and compare the beliefs about cannabis, its use and potential consequences between two groups of Colombian university students, matched by gender and age. The frst group consisted of ordinary consumers of cannabis (n=35) the second group consisted of students that have never tried cannabis (n=35). The results showed that the group of consumers presents a moderate risk of abuse and only the 20% fulflled dependence criteria...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28895518/lactobacillus-curtus-sp-nov-isolated-from-beer-in-finland
#17
Yuki Asakawa, Nobuchika Takesue, Shizuka Asano, Satoshi Shimotsu, Kazumaru Iijima, Koji Suzuki, Yasuo Motoyama, Masayuki Aizawa
A Gram-stain-positive, catalase-negative and short-rod-shaped organism, designated VTT E-94560, was isolated from beer in Finland and deposited in the VTT culture collection as a strain of Lactobacillus rossiae. However, the results of 16S rRNA gene sequence analysis showed that VTT E-94560 was only related to Lactobacillus rossiae JCM 16176T with 97.0 % sequence similarity, lower than the 98.7 % regarded as the boundary for the species differentiation. Additional phylogenetic studies on the pheS gene, rpoA gene and 16S-23S rRNA internally transcribed spacer region further reinforced the taxonomically independent status of VTT E-94560 and its related Lactobacillus species including L...
September 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28893988/cryo-em-structure-of-the-bacteriophage-t4-isometric-head-at-3-3-%C3%A3-resolution-and-its-relevance-to-the-assembly-of-icosahedral-viruses
#18
Zhenguo Chen, Lei Sun, Zhihong Zhang, Andrei Fokine, Victor Padilla-Sanchez, Dorit Hanein, Wen Jiang, Michael G Rossmann, Venigalla B Rao
The 3.3-Å cryo-EM structure of the 860-Å-diameter isometric mutant bacteriophage T4 capsid has been determined. WT T4 has a prolate capsid characterized by triangulation numbers (T numbers) Tend = 13 for end caps and Tmid = 20 for midsection. A mutation in the major capsid protein, gp23, produced T=13 icosahedral capsids. The capsid is stabilized by 660 copies of the outer capsid protein, Soc, which clamp adjacent gp23 hexamers. The occupancies of Soc molecules are proportional to the size of the angle between the planes of adjacent hexameric capsomers...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28893667/amnestic-drugs-in-the-odor-span-task-effects-of-flunitrazepam-zolpidem-and-scopolamine
#19
Mark Galizio, Michael Mathews, Madeleine Mason, Danielle Panoz-Brown, Ashley Prichard, Paul Soto
The odor span task is an incrementing non-matching-to-sample procedure designed to provide an analysis of working memory capacity in rodents. The procedure takes place in an arena apparatus and rats are exposed to a series of odor stimuli in the form of scented lids with the selection of new stimuli reinforced. This procedure makes it possible to study drug effects as a function of the number of stimuli to remember. In the present study, the non-selective positive allosteric GABAA receptor modulator flunitrazepam impaired odor span performance at doses that did not affect a control odor discrimination...
September 8, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28893485/-clinical-characteristics-and-course-of-hand-foot-and-mouth-disease
#20
A Mirand, H Peigue-Lafeuille
Hand, foot and mouth disease (HFMD) and herpangina (HA) are common childhood diseases mostly associated with human enteroviruses (EV). Although usually benign illnesses, neurological complications may be observed during large epidemics when enterovirus A71 (EV-A71) is involved, as observed in the Asia Pacific Region and in China since the late 1990s. The occurrence of these complications warrants reinforcing the surveillance of the emergence of EV-A71 infections in France and Europe. Monitoring EV infections associated with HFMD can be considered as an effective tool to detect an upsurge of EV-A71 infections in a timely manner...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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