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https://www.readbyqxmd.com/read/28110218/hydrogen-peroxide-as-a-central-redox-signaling-molecule-in-physiological-oxidative-stress-oxidative-eustress
#1
REVIEW
Helmut Sies
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing, signaling and redox regulation. Generation, transport and capture of H2O2 in biological settings as well as their biological consequences can now be addressed. The present overview focuses on recent progress on metabolic sources and sinks of H2O2 and on the role of H2O2 in redox signaling under physiological conditions (1-10nM), denoted as oxidative eustress. Higher concentrations lead to adaptive stress responses via master switches such as Nrf2/Keap1 or NF-κB...
January 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/28110133/identification-of-potential-antioxidant-indices-by-biogenic-gold-nanoparticles-in-hyperglycemic-wistar-rats
#2
Manimegalai Sengani, V Devirajeswari
Oxidative stress is a crucial factor in diabetes, where the abnormal metabolic ambience leads to hyperglycemia resulting in the onset of several vascular complications. Under homeostasis, innate antioxidants efficiently inhibit the oxidative stress, thereby restrain further progression of diabetes. In the present study, a potential antioxidant marker was identified from hepatic tissue of diabetic Wistar rats after oral administration of biogenic gold nanoparticles (GNPs). Diabetic animals treated with GNPs showed increase in insulin level and subsequently reduced the concentration of blood glucose level to normal...
January 15, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28110128/application-of-a-breakthrough-biosorbent-for-removing-heavy-metals-from-synthetic-and-real-wastewaters-in-a-lab-scale-continuous-fixed-bed-column
#3
Atefeh Abdolali, Huu Hao Ngo, Wenshan Guo, John L Zhou, Jian Zhang, Shuang Liang, Soon W Chang, Dinh Duc Nguyen, Yi Liu
A continuous fixed-bed study was carried out utilising a breakthrough biosorbent, specifically multi-metal binding biosorbent (MMBB) for removing cadmium, copper, lead and zinc. The effect of operating conditions, i.e. influent flow rate, metal concentration and bed depth was investigated at pH 5.5±0.1 for a synthetic wastewater sample. Results confirmed that the total amount of metal adsorption declined with increasing influent flow rate and also rose when each metal concentration also increased. The maximum biosorption capacities of 38...
January 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28110117/an-adaptive-method-for-determining-an-acquisition-parameter-t0-in-a-modified-cpmg-sequence
#4
Donghui Xing, Yiren Fan, Jianfei Hao, Xinmin Ge, Chaoliu Li, Yufeng Xiao, Fei Wu
The modified CPMG (Carr-Purcell-Meiboom-Gill) pulse sequence is a common sequence used for measuring the internal magnetic field gradient distribution of formation rocks, for which t0 (the duration of the first window) is a key acquisition parameter. In order to obtain the optimal t0, an adaptive method is proposed in this paper. By studying the factors influencing discriminant factor σ and its variation trend using T2-G forward numerical simulation, it is found that the optimal t0 corresponds to the maximum value of σ...
January 9, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28110078/escherichia-coli-hgt-engineered-for-high-glucose-throughput-even-under-slowly-growing-or-resting-conditions
#5
Annette Michalowski, Martin Siemann-Herzberg, Ralf Takors
Aerobic production-scale processes are constrained by the technical limitations of maximum oxygen transfer and heat removal. Consequently, microbial activity is often controlled via limited nutrient feeding to maintain it within technical operability. Here, we present an alternative approach based on a newly engineered Escherichia coli strain. This E. coli HGT (high glucose throughput) strain was engineered by modulating the stringent response regulation program and decreasing the activity of pyruvate dehydrogenase...
January 18, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28109816/preparation-of-magnetic-graphene-oxide-ferrite-nanocomposites-for-oxidative-decomposition-of-remazol-black-b
#6
Shabnam Sheshmani, Behnaz Falahat, Farrokh Roya Nikmaram
A solvothermal synthesis method was used to prepare graphene oxide (GO) supported ferrite (MFe2O4, M=Fe, Co and Ni) nanocomposites. Subsequently, the application of MFe2O4 nanocomposites as adsorbent for Remazol Black B (RBB) removal was investigated. The nanocomposites were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectra (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and vibrating sample magnetometer. It was shown that dispersed MFe2O4 microspheres with uniform size (20-30nm) were homogeneously deposited on GO nanosheets...
January 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28109781/teasing-apart-coercion-and-surprisal-evidence-from-eye-movements-and-erps
#7
Francesca Delogu, Matthew W Crocker, Heiner Drenhaus
Previous behavioral and electrophysiological studies have presented evidence suggesting that coercion expressions (e.g., began the book) are more difficult to process than control expressions like read the book. While this processing cost has been attributed to a specific coercion operation for recovering an event-sense of the complement (e.g., began reading the book), an alternative view based on the Surprisal Theory of language processing would attribute the cost to the relative unpredictability of the complement noun in the coercion compared to the control condition, with no need to postulate coercion-specific mechanisms...
January 18, 2017: Cognition
https://www.readbyqxmd.com/read/28109381/endovascular-technique-for-repair-of-descending-thoracic-aortic-aneurysm-after-coarctation-operation
#8
Heike Baumgarten, John J Squiers, William T Brinkman, Javier Vasquez
The incidence of aneurysm after open surgical repair of coarctation is 11% to 24%. If the condition is left untreated, fatal rupture may occur. Thoracic endovascular aortic repair (TEVAR) has been reported as a feasible and safe alternative to open surgical repeated procedures in this context. However, TEVAR might be challenging because of the proximity of the pathologic condition to the supraaortic vessels and the ongoing presence of the coarctation. We report a unique case of a 48-year old man undergoing TEVAR because of aortic aneurysm after previous surgical coarctation treatment and successful closure of the coarctation with a vascular plug device...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109104/-clinical-significance-of-peripheral-blood-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-patients-with-asthma
#9
Guang Shi, Jun-Wei Zhao, Liang Ming
OBJECTIVE: To investigate the changes of peripheral blood neutrophil-lymphocyte ratio (NLR) and platelet- lymphocyte ratio (PLR) in patients in acute stage of bronchial asthma and their clinical significance. METHODS: A total of 262 patients with acute asthma, including 97 critical and 175 non-critical patients, were recruited from our hospital between January, 2013 and May, 2016, with 130 healthy individuals as the control group. The absolute neutrophil count, absolute lymphocyte count, platelet, NLR and PLR were compared among different groups, and their diagnostic values were evaluated using the area under the receiver-operating characteristic (ROC) curve...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28108759/from-microhabitat-of-floral-nectar-up-to-biogeographic-scale-novel-insights-on-neutral-and-niche-bacterial-assemblies
#10
Yana Aizenberg-Gershtein, Ido Izhaki, Malka Halpern
Microbial model systems are very useful in addressing macro-ecological questions. Two major theories exist to date, to explain the community structure of organisms: (1) the dispersal (neutral) assembly theory which predicts that community similarity decreases with increasing geographic distance, independent of any environmental variables, and (2) the niche assembly theory which predicts that the communities' compositions are more homogeneous among sites characterized by similar environmental conditions. Our study system offered a unique opportunity to investigate the relative role of environmental conditions and spatial factors in shaping community composition...
January 20, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28108546/automatic-health-record-review-to-help-prioritize-gravely-ill-social-security-disability-applicants
#11
Kenneth Abbott, Yen-Yi Ho, Jennifer Erickson
OBJECTIVE: Every year, thousands of patients die waiting for disability benefits from the Social Security Administration. Some qualify for expedited service under the Compassionate Allowance (CAL) initiative, but CAL software focuses exclusively on information from a single form field. This paper describes the development of a supplemental process for identifying some overlooked but gravely ill applicants, through automatic annotation of health records accompanying new claims. We explore improved prioritization instead of fully autonomous claims approval...
January 20, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28108065/assessment-of-central-venous-physiology-of-fontan-circulation-using-peripheral-venous-pressure
#12
Satoshi Masutani, Clara Kurishima, Akiko Yana, Seiko Kuwata, Yoichi Iwamoto, Hirofumi Saiki, Hirotaka Ishido, Hideaki Senzaki
OBJECTIVE: Elevated central venous pressure is a major cause of morbidity and mortality after the Fontan operation. The difference between mean circulatory filling pressure and central venous pressure, a driving force of venous return, is important in determining dynamic changes in central venous pressure in response to changes in ventricular properties or loading conditions. Thus, noninvasive central venous pressure and mean circulatory filling pressure estimation may contribute to optimal management in patients undergoing the Fontan operation...
December 19, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28107930/a-chemiluminescent-aptasensor-based-on-rolling-circle-amplification-and-co-2-n-aminobutyl-n-ethylisoluminol-functional-flowerlike-gold-nanoparticles-for-salmonella-typhimurium-detection
#13
Liling Hao, Huajie Gu, Nuo Duan, Shijia Wu, Xiaoyuan Ma, Yu Xia, Haitao Wang, Zhouping Wang
A sensitive steady-state chemiluminescent aptasensor based on rolling circle amplification (RCA) was fabricated for the detection of Salmonella typhimurium. The sensor utilized aptamer modified Fe3O4 magnetic nanoparticles (MNPs) as capture probes, aptamer as recognition molecules, and Co(2+) enhanced N‑(aminobutyl)-N-(ethylisoluminol) (ABEI) functional flowerlike gold nanoparticles (AuNFs) and complementary strand (cDNA) complex (Co(2+)/ABEI-AuNFs-cDNA) as signal probes. And P-Iodophenol (PIP) was also added to form a typical ABEI- AuNFs-PIP-H2O2 steady-state CL system...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107783/lorcaserin-suppresses-oxycodone-self-administration-and-relapse-vulnerability-in-rats
#14
Harshini Neelakantan, Erica D Holliday, Robert G Fox, Sonja J Stutz, Sandra D Comer, Margaret Haney, Noelle C Anastasio, Frederick Gerard Moeller, Kathryn A Cunningham
Opioid use disorder (OUD) is a major public health problem. High relapse rates and poor treatment retention continue to pose major challenges in OUD treatment. Of the abused opioids, oxycodone is well described to maintain self-administration and evoke the durable conditioned responses ("cue reactivity") that result from pairing of opioid-related stimuli (e.g., paraphernalia) with repeated abuse. Serotonin (5-HT) neurotransmission, particularly through the 5-HT2C receptor (5-HT2CR), regulates psychostimulant reward and cue reactivity, and in the present experiments, we investigated the hypothesis that the selective 5-HT2CR agonist lorcaserin, which is FDA-approved for the treatment of obesity, will suppress oxycodone self-administration and oxycodone-associated cue reactivity in rats...
January 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28107772/a-preliminary-randomized-controlled-trial-of-contingency-management-for-alcohol-use-reduction-using-a-transdermal-alcohol-sensor
#15
Nancy P Barnett, Mark A Celio, Jennifer W Tidey, James G Murphy, Suzanne M Colby, Robert M Swift
AIMS: We tested the efficacy of daily contingent reinforcement for reducing alcohol use compared with (yoked) noncontingent reinforcement (NR) using a transdermal alcohol sensor to detect alcohol use. DESIGN: Pilot randomized controlled design with one baseline week, three intervention weeks, and one-month follow up. SETTING: New England, USA. PARTICIPANTS: Heavy drinking adults (47% female) not seeking treatment were randomized to 1) an escalating schedule of cash reinforcement (CR; n =15) for days on which alcohol was neither reported nor detected or 2) yoked NR (n =15)...
January 20, 2017: Addiction
https://www.readbyqxmd.com/read/28107370/neuronal-injury-and-glial-changes-are-hallmarks-of-open-field-blast-exposure-in-swine-frontal-lobe
#16
Srinivasu Kallakuri, Alok Desai, Ke Feng, Sharvani Tummala, Tal Saif, Chaoyang Chen, Liying Zhang, John M Cavanaugh, Albert I King
With the rapid increase in the number of blast induced traumatic brain injuries and associated neuropsychological consequences in veterans returning from the operations in Iraq and Afghanistan, the need to better understand the neuropathological sequelae following exposure to an open field blast exposure is still critical. Although a large body of experimental studies have attempted to address these pathological changes using shock tube models of blast injury, studies directed at understanding changes in a gyrencephalic brain exposed to a true open field blast are limited and thus forms the focus of this study...
2017: PloS One
https://www.readbyqxmd.com/read/28107084/can-diffusion-weighted-imaging-and-related-apparent-diffusion-coefficient-be-a-prognostic-value-in-women-with-breast-cancer
#17
Paola Rabasco, Rocchina Caivano, Vittorio Simeon, Giuseppina Dinardo, Antonella Lotumolo, Matilde Gioioso, Antonio Villonio, Giancarlo Iannelli, Felice D'Antuono, Alexis Zandolino, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To analyze diffusion-weighted imaging (DWI) and the related apparent diffusion coefficient (ADC) in women with breast cancer, correlating these values with the presence at 3 years of distant metastases, and to demonstrate that DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a prognostic value in the study of women with breast cancer. MATERIALS AND METHODS: Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 3 years were enrolled...
January 20, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28107013/quaternary-n-2-pyridyl-dabco-salts-one-pot-in-situ-formation-from-pyridine-n-oxides-and-reactions-with-nucleophiles-a-mild-and-selective-route-to-substituted-n-2-pyridyl-n-ethylpiperazines
#18
Dmitry I Bugaenko, Marina A Yurovskaya, Alexander V Karchava
The N-(2-pyridyl)-N'-ethylpiperazines are important structural motifs in several medicinally relevant compounds. Known synthetic methods toward these structures are multistep and generally based on the SNAr-chemistry; their applicability is significantly limited to substrates containing electron-withdrawing groups. Here we describe a new methodology for a rapid and modular access to this privileged scaffold. Importantly, the developed protocol proved to be very general and efficient for the substrates containing substituents of different electronic nature...
January 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28106817/value-based-caching-in-information-centric-wireless-body-area-networks
#19
Fadi M Al-Turjman, Muhammad Imran, Athanasios V Vasilakos
We propose a resilient cache replacement approach based on a Value of sensed Information (VoI) policy. To resolve and fetch content when the origin is not available due to isolated in-network nodes (fragmentation) and harsh operational conditions, we exploit a content caching approach. Our approach depends on four functional parameters in sensory Wireless Body Area Networks (WBANs). These four parameters are: age of data based on periodic request, popularity of on-demand requests, communication interference cost, and the duration for which the sensor node is required to operate in active mode to capture the sensed readings...
January 19, 2017: Sensors
https://www.readbyqxmd.com/read/28106775/colloidal-fouling-of-nanofiltration-membranes-development-of-a-standard-operating-procedure
#20
Md Abdullaha Al Mamun, Subir Bhattacharjee, David Pernitsky, Mohtada Sadrzadeh
Fouling of nanofiltration (NF) membranes is the most significant obstacle to the development of a sustainable and energy-efficient NF process. Colloidal fouling and performance decline in NF processes is complex due to the combination of cake formation and salt concentration polarization effects, which are influenced by the properties of the colloids and the membrane, the operating conditions of the test, and the solution chemistry. Although numerous studies have been conducted to investigate the influence of these parameters on the performance of the NF process, the importance of membrane preconditioning (e...
January 18, 2017: Membranes
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