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https://www.readbyqxmd.com/read/28643015/the-role-of-screening-mri-in-the-era-of-next-generation-sequencing-and-moderate-risk-genetic-mutations
#1
REVIEW
Sarah Macklin, Jennifer Gass, Ghada Mitri, Paldeep S Atwal, Stephanie Hines
With the advent of next-generation sequencing, the ability to rapidly analyze numerous genes simultaneously has led to the creation of large cancer gene panels. Some of these genes, like BRCA1 and BRCA2, have been heavily researched and have well-established management guidelines. Other more newly established genes, like ATM, CHEK2, and PALB2, have previously had less robust research surrounding them which has limited the ability to create accurate risk estimates. With their inclusion on gene panels, there has been more pressure to produce management guidelines for patients discovered to carry pathogenic variants in these genes...
June 22, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28624977/interaction-of-mammographic-breast-density-with-menopausal-status-and-postmenopausal-hormone-use-in-relation-to-the-risk-of-aggressive-breast-cancer-subtypes
#2
Lusine Yaghjyan, Rulla M Tamimi, Kimberly A Bertrand, Christopher G Scott, Matthew R Jensen, V Shane Pankratz, Kathy Brandt, Daniel Visscher, Aaron Norman, Fergus Couch, John Shepherd, Bo Fan, Yunn-Yi Chen, Lin Ma, Andrew H Beck, Steven R Cummings, Karla Kerlikowske, Celine M Vachon
PURPOSE: We examined the associations of mammographic breast density with breast cancer risk by tumor aggressiveness and by menopausal status and current postmenopausal hormone therapy. METHODS: This study included 2596 invasive breast cancer cases and 4059 controls selected from participants of four nested case-control studies within four established cohorts: the Mayo Mammography Health Study, the Nurses' Health Study, Nurses' Health Study II, and San Francisco Mammography Registry...
June 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28622679/neighborhood-structural-similarity-mapping-for-the-classification-of-masses-in-mammograms
#3
Rinku Rabidas, Abhishek Midya, Jayasree Chakraborty
In this paper, two novel feature extraction methods, using Neighborhood Structural Similarity (NSS), are proposed for the characterization of mammographic masses as benign or malignant. Since the gray-level distribution of pixels is different in benign and malignant masses; more regular and homogeneous patterns are visible in benign masses compared to malignant masses, the proposed method exploits the similarity between neighboring regions of masses by designing two new features, namely NSS-I and NSS-II, which capture global similarity at different scales...
June 13, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28621548/an-investigation-into-the-mammographic-appearances-of-missed-breast-cancers-when-recall-rates-are-reduced
#4
Norhashimah Mohd Norsuddin, Claudia Mello-Thoms, Warren Reed, Mary Rickard, Sarah Lewis
OBJECTIVES: This study investigated whether certain mammographic appearances of breast cancer are missed when radiologists read at lower recall rates. METHODS: Five radiologists read one identical test set of 200 mammographic (180 normal cases and 20 abnormal cases) three times and were requested to adhere to three different recall rate conditions: free recall, 15% and 10%. The radiologists were asked to mark the locations of suspicious lesions and provide a confidence rating for each decision...
June 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28617264/the-professional-quality-criteria-of-italian-breast-screening-radiologists-results-from-a-national-survey-comparing-the-programmes-started-in-2000-2012-versus-the-ones-started-in-1990-1999
#5
Doralba Morrone, Livia Giordano, Franca Artuso, Daniela Bernardi, Chiara Fedato, Alfonso Frigerio, Daniela Giorgi, Carlo Naldoni, Gianni Saguatti, Daniela Severi, Mario Taffurelli, Daniela Terribile, Leonardo Ventura, Lauro Bucchi
INTRODUCTION: In Italy, due to increasing healthcare budget and staff shortages, the recently created regional mammography screening programmes were established under worse radiology practice quality criteria than the previously created programmes. METHODS: Using available data from a national questionnaire survey conducted at the end of 2013 and involving 222 responder radiologists, we compared the main professional quality standards of radiologists working in the screening programmes established during the period 2000-2012 with those working in the screening programmes created from 1990 to 1999...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28615408/examining-screening-mammography-participation-among-women-aged-40-to-74
#6
Karena D Volesky, Paul J Villeneuve
OBJECTIVE: To examine participation in screening mammography among women aged 40 to 74 and identify which factors are associated with those women who participate in screening. DESIGN: Secondary analysis of the cross-sectional 2012 Canadian Community Health Survey. SETTING: Canada. PARTICIPANTS: A population-based national sample of 18 312 women aged 40 to 74. MAIN OUTCOME MEASURES: Women's participation in screening mammography in the 2 years preceding the 2012 Canadian Community Health Survey; women's preventive health activities (ie, having a regular doctor, a recent physical checkup, and a Papanicolaou test), which were adjusted for sociodemographic factors...
June 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28614990/screening-organization-and-recall-rate-in-a-regional-breast-screening-programme
#7
Tina Beruchashwili, Rema Gvamichava, Stephen W Duffy
Objective To use results on recall rates from a regional non-population-based breast screening programme to inform practice in a planned national population-based programme. Methods We analysed data on rates of recall for further assessment in 27,327 mammographic screening episodes in 2015-2016 in the breast screening programme in the city of Tbilisi, Georgia. Screening was done by two-view digital mammography with double reading in women aged 40-70, and further assessment took place at the same clinic and during the same visit as the initial screening mammogram...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28614046/cancer-risk-factors-and-screening-in-first-nations-in-ontario
#8
Maegan V Mazereeuw, Alexander Yurkiewich, Sehar Jamal, Caroline Cawley, Carmen R Jones
INTRODUCTION: A lack of identifiers in health administrative databases limits our understanding of the cancer burden in First Nations. This study compares cancer risk factors and screening between First Nations in Ontario (on and off reserve) and non-Aboriginal Ontarians using two unique health surveys. METHODS: We measured age-standardized prevalence estimates using the First Nations Regional Health Survey (RHS) Phase 2, 2008/10 (for First Nations on reserve) and the Canadian Community Health Survey (CCHS), 2007-2013 (for First Nations off reserve and non-Aboriginal Ontarians)...
June 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28613915/inter-country-analysis-of-breast-density-classification-using-visual-grading
#9
Christine N Damases, Peter Hogg, Mark F McEntee
OBJECTIVE: Disagreement in mammographic breast density (MBD) assessment can impact breast cancer risk stratification, choices of further breast cancer screening intervals and pathways. This study examines whether inter-country MBD expectations and assessment approaches are associated with differences in MBD assessment. METHODS: Twenty American Board of Radiology (ABR) examiners and 24 United Kingdom (UK) practitioners using the 4(th) edition BI-RADS(®) lexicon assessed 40 mammogram cases of 20 women...
June 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28611851/acceleration-of-image-segmentation-algorithm-for-breast-mammogram-images-using-high-performance-reconfigurable-dataflow-computers
#10
Ivan L Milankovic, Nikola V Mijailovic, Nenad D Filipovic, Aleksandar S Peulic
Image segmentation is one of the most common procedures in medical imaging applications. It is also a very important task in breast cancer detection. Breast cancer detection procedure based on mammography can be divided into several stages. The first stage is the extraction of the region of interest from a breast image, followed by the identification of suspicious mass regions, their classification, and comparison with the existing image database. It is often the case that already existing image databases have large sets of data whose processing requires a lot of time, and thus the acceleration of each of the processing stages in breast cancer detection is a very important issue...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28606722/fully-automated-breast-boundary-and-pectoral-muscle-segmentation-in-mammograms
#11
Andrik Rampun, Philip J Morrow, Bryan W Scotney, John Winder
Breast and pectoral muscle segmentation is an essential pre-processing step for the subsequent processes in computer aided diagnosis (CAD) systems. Estimating the breast and pectoral boundaries is a difficult task especially in mammograms due to artifacts, homogeneity between the pectoral and breast regions, and low contrast along the skin-air boundary. In this paper, a breast boundary and pectoral muscle segmentation method in mammograms is proposed. For breast boundary estimation, we determine the initial breast boundary via thresholding and employ Active Contour Models without edges to search for the actual boundary...
June 9, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28603939/mesh-free-based-variational-level-set-evolution-for-breast-region-segmentation-and-abnormality-detection-using-mammograms
#12
Kanchan L Kashyap, Manish K Bajpai, Pritee Khanna, George Giakos
Automatic segmentation of abnormal region is a crucial task in computer aided detection system using mammograms. In this work an automatic abnormality detection algorithm using mammographic images is proposed. In the preprocessing step, partial differential equation based variational level set method is employed for breast region extraction. The evolution of the level set method is done by applying mesh-free based radial basis function. The limitation of mesh-based approach is removed by using mesh-free based RBF method...
June 11, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28603859/disparities-in-abnormal-mammogram-follow-up-time-for-asian-women-compared-with-non-hispanic-white-women-and-between-asian-ethnic-groups
#13
Kim H Nguyen, Rena J Pasick, Susan L Stewart, Karla Kerlikowske, Leah S Karliner
BACKGROUND: Delays in abnormal mammogram follow-up contribute to poor outcomes. In the current study, the authors examined differences in abnormal screening mammogram follow-up between non-Hispanic white (NHW) and Asian women. METHODS: The authors used a prospective cohort of NHW and Asian women with a Breast Imaging, Reporting and Data System (BI-RADS) abnormal result of category 0 or 3-plus in the San Francisco Mammography Registry between 2000 and 2010. Kaplan-Meier estimation for the median number of days to follow-up with a diagnostic radiologic test was performed, and the authors compared the percentage of women with follow-up at 30 days, 60 days, and 90 days and no follow-up at 1 year for Asian women overall (and Asian ethnic groups) and NHW women...
June 12, 2017: Cancer
https://www.readbyqxmd.com/read/28601611/evaluation-of-the-angelina-jolie-effect-on-screening-mammography-utilization-in-an-academic-center
#14
Marco D Huesch, Susann Schetter, Joel Segel, Alison Chetlen
PURPOSE: The aim of this study was to understand the impact on screening mammography at our institution, comparing weekly utilization in the 2 years before and the 2 years after Ms Angelina Jolie disclosed in the New York Times on May 13, 2013, that she had had a prophylactic double mastectomy. METHODS: All 48,110 consecutive screening mammograms conducted at our institution between May 16, 2011, and May 16, 2015, were selected from our electronic medical record system...
June 7, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28590426/down-s-syndrome-and-triple-negative-breast-cancer-a-rare-occurrence-of-distinctive-clinical-relationship
#15
Nandini Dey, Amy Krie, Jessica Klein, Kirstin Williams, Amanda McMillan, Rachel Elsey, Yuliang Sun, Casey Williams, Pradip De, Brian Leyland-Jones
Down's syndrome (DS), the most common genetic cause of significant intellectual disability in children and adults is caused by the trisomy of either all or a part of human chromosome 21 (HSA21). Patients with DS mostly suffer from characteristic tumor types. Although individual patients of DS are at a higher risk for acute leukemia and testicular cancers, other types of solid tumors including breast cancers are mostly uncommon and have significantly lower-than-expected age-adjusted incidence rates. Except for an increased risk of retinoblastomas, and lymphomas, the risk of developing solid tumors has been found to be lower in both children and adults, and breast cancer was found to be almost absent (Hasle H...
June 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28586291/evaluation-of-the-utility-of-screening-mammography-for-high-risk-women-undergoing-screening-breast-mr-imaging
#16
Glen Lo, Anabel M Scaranelo, Hana Aboras, Sandeep Ghai, Supriya Kulkarni, Rachel Fleming, Karina Bukhanov, Pavel Crystal
Purpose To evaluate the value of mammography in detecting breast cancer in high-risk women undergoing screening breast magnetic resonance (MR) imaging. Materials and Methods An ethics-approved, retrospective review of prospective databases was performed to identify outcomes of 3934 screening studies (1977 screening MR imaging examinations and 1957 screening mammograms) performed between January 2012 and July 2014 in 1249 high-risk women. Performance measures including recall and cancer detection rates, sensitivity, specificity, and positive predictive values were calculated for both mammography and MR imaging...
June 6, 2017: Radiology
https://www.readbyqxmd.com/read/28582921/grouped-fuzzy-svm-with-em-based-partition-of-sample-space-for-clustered-microcalcification-detection
#17
Huiya Wang, Jun Feng, Hongyu Wang
BACKGROUND: Detection of clustered microcalcification (MC) from mammograms plays essential roles in computer-aided diagnosis for early stage breast cancer. OBJECTIVE: To tackle problems associated with the diversity of data structures of MC lesions and the variability of normal breast tissues, multi-pattern sample space learning is required. METHODS: In this paper, a novel grouped fuzzy Support Vector Machine (SVM) algorithm with sample space partition based on Expectation-Maximization (EM) (called G-FSVM) is proposed for clustered MC detection...
May 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28573551/two-dimensional-breast-dosimetry-improved-using-three-dimensional-breast-image-data
#18
REVIEW
John M Boone, Andrew M Hernandez, J Anthony Seibert
Conventional mammographic dosimetry has been developed over the past 40 years. Prior to the availability of high-resolution three-dimensional breast images, certain assumptions about breast anatomy were required. These assumptions were based on the information evident on two-dimensional mammograms; they included assumptions of thick skin, a uniform mixture of glandular and adipose tissue, and a median breast density of 50%. Recently, the availability of high-resolution breast CT studies has provided more accurate data about breast anatomy, and this, in turn, has provided the opportunity to update mammographic dosimetry...
June 1, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28569996/technical-note-validation-of-two-methods-to-determine-contact-area-between-breast-and-compression-paddle-in-mammography
#19
Woutjan Branderhorst, Jerry E de Groot, Monique G J T B van Lier, Ralph P Highnam, Gerard J den Heeten, Cornelis A Grimbergen
PURPOSE: To assess the accuracy of two methods of determining the contact area between the compression paddle and the breast in mammography. An accurate method to determine the contact area is essential to accurately calculate the average compression pressure applied by the paddle. METHODS: For a set of 300 breast compressions, we measured the contact areas between breast and paddle, both capacitively using a transparent foil with indium-tin-oxide (ITO) coating attached to the paddle, and retrospectively from the obtained mammograms using image processing software (Volpara Enterprise, algorithm version 1...
June 1, 2017: Medical Physics
https://www.readbyqxmd.com/read/28558329/risk-stratification-of-women-with-false-positive-test-results-in-mammography-screening-based-on-mammographic-morphology-and-density-a-case-control-study
#20
Rikke Rass Winkel, My von Euler-Chelpin, Elsebeth Lynge, Pengfei Diao, Martin Lillholm, Michiel Kallenberg, Julie Lyng Forman, Michael Bachmann Nielsen, Wei Yao Uldall, Mads Nielsen, Ilse Vejborg
The long-term risk of breast cancer is increased in women with false-positive (FP) mammography screening results. We investigated whether mammographic morphology and/or density can be used to stratify these women according to their risk of future breast cancer METHODS: We undertook a case-control study nested in the population-based screening programme in Copenhagen, Denmark. We included 288 cases and 288 controls based on a cohort of 4743 women with at least one FP-test result in 1991-2005 who were followed up until 17 April 2008...
May 27, 2017: Cancer Epidemiology
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