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https://www.readbyqxmd.com/read/29298819/reduction-of-motion-sickness-through-targeting-histamine-n-methyltransferase-in-the-dorsal-vagal-complex-of-the-brain
#1
Miao-Miao Chen, Li-Hua Xu, Li Chang, Peng Yin, Zheng-Lin Jiang
To investigate the role of histamine N-methyltransferase (HNMT) activity in the development of motion sickness (MS) in the dorsal vagal complex (DVC) to inform the development of new drugs for MS, Beagle dogs and Sprague-Dawley rats were rotated to simulate MS. HNMT expression in the brain stem and DVC was measured. The effects of systemic application of tacrine, a HNMT inhibitor, on the development of MS were observed. Moreover, we microinjected a histamine receptor H1 inhibitor, promethazine, into the DVC to verify the involvement of histaminergic neurotransmission in MS...
January 3, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29290418/effect-of-high-intensity-perturbations-during-core-specific-sensorimotor-exercises-on-trunk-muscle-activation
#2
Juliane Mueller, Miralem Hadzic, Hendrik Mugele, Josefine Stoll, Steffen Mueller, Frank Mayer
Core-specific sensorimotor exercises are proven to enhance neuromuscular activity of the trunk. However, the influence of high-intensity perturbations on training efficiency is unclear within this context. Sixteen participants (29±2yrs; 175±8cm; 69±13kg) were prepared with a 12-lead bilateral trunk EMG. Warm-up on a dynamometer was followed by maximum voluntary isometric trunk (flex/ext) contraction (MVC). Next, participants performed four conditions for a one-legged stance with hip abduction on a stable surface (HA) repeated randomly on an unstable surface (HAP), on a stable surface with perturbation (HA+P), and on an unstable surface with perturbation (HAP+P)...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29281096/relating-experimentally-induced-fear-to-pre-existing-phobic-fear-in-the-human-brain
#3
Seth M Levine, Michael Pfaller, Jonas Reichenberger, Youssef Shiban, Andreas Mühlberger, Rainer Rupprecht, Jens V Schwarzbach
While prior work has demonstrated that fear-conditioning changes the neural representation of previously neutral stimuli, it remains unknown to what extent this new representation abstracts away from specific fears and which brain areas are involved therein. To investigate this question, we sought commonalities between experimentally-induced fear via electric shocks and pre-existing phobia. Using functional MRI, we tested the effect of fear-conditioning pictures of dogs in 21 spider-fearful participants across three phases: baseline, post-conditioning, and extinction...
December 21, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29275324/use-of-clinical-vignette-questionnaires-to-investigate-the-variation-in-management-of-keratoconjunctivitis-sicca-and-acute-glaucoma-in-dogs
#4
Constance N White, Martin J Downes, Gareth Jones, Corinne Wigfall, Rachel S Dean, Marnie L Brennan
There is little peer-reviewed research assessing therapeutic effectiveness in canine eye disease. Current treatments used in first opinion and ophthalmology referral practices are also somewhat poorly documented. The aim of this study was to investigate the current management of canine keratoconjunctivitis sicca (KCS) and acute primary angle-closure glaucoma (PACG) by veterinary surgeons. Questionnaires using clinical vignettes were administered to a cross section of general practitioners ('GPs') and veterinarians engaged in or training for postgraduate ophthalmology practice ('PGs')...
December 23, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29244607/a-survey-of-risk-factors-for-digit-injuries-among-dogs-training-and-competing-in-agility-events
#5
Debra C Sellon, Katherine Martucci, John R Wenz, Denis J Marcellin-Little, Michelle Powers, Kimberley L Cullen
OBJECTIVE To identify potential risk factors for digit injuries in dogs training and competing in agility events. DESIGN Internet-based, retrospective, cross-sectional survey. ANIMALS 1,081 dogs training or competing in agility events. PROCEDURES Data were collected for eligible animals via retrospective surveys distributed electronically to handlers of dogs participating in agility-related activities. Variables evaluated included demographic (handlers) and signalment (dogs) information, physical characteristics of dogs, and injury characteristics...
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29214623/core-temperature-responses-of-military-working-dogs-during-training-activities-and-exercise-walks
#6
Catherine O'Brien, Anthony J Karis, William J Tharion, Heather M Sullivan, Reed W Hoyt
Heat strain is common in military working dogs (MWDs), but can be mitigated by limiting duration of activity to avoid overheating and allowing sufficient time for recovery. To determine work/rest times for MWDs, temperature responses during training must be characterized. This study measured body core temperature of 48 MWDs at Lackland Air Force Base, San Antonio, TX. Twenty-four MWDs in training for patrol and detection activities participated under a range of ambient temperatures in August (27°C-32°C), October (22°C-26°C) and March (approximately 13°C)...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29206864/high-visual-acuity-revealed-in-dogs
#7
Olle Lind, Ida Milton, Elin Andersson, Per Jensen, Lina S V Roth
Humans have selectively bred and used dogs over a period of thousands of years, and more recently the dog has become an important model animal for studies in ethology, cognition and genetics. These broad interests warrant careful descriptions of the senses of dogs. Still there is little known about dog vision, especially what dogs can discriminate in different light conditions. We trained and tested whippets, pugs, and a Shetland sheepdog in a two-choice discrimination set-up and show that dogs can discriminate patterns with spatial frequencies between 5...
2017: PloS One
https://www.readbyqxmd.com/read/29205620/interobserver-reliability-of-computed-tomographic-contouring-of-canine-tonsils-in-radation-therapy-treatment-planning
#8
Keiko Murakami, Nicholas J Rancilio, Jeannie Poulson Plantenga, George E Moore, Hock Gan Heng, Chee Kin Lim
In radiation therapy (RT) treatment planning for canine head and neck cancer, the tonsils may be included as part of the treated volume. Delineation of tonsils on computed tomography (CT) scans is difficult. Error or uncertainty in the volume and location of contoured structures may result in treatment failure. The purpose of this prospective, observer agreement study was to assess the interobserver agreement of tonsillar contouring by two groups of trained observers. Thirty dogs undergoing pre- and post-contrast CT studies of the head were included...
December 4, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29190195/puppy-socialization-practices-of-a-sample-of-dog-owners-from-across-canada-and-the-united-states
#9
Janet H Cutler, Jason B Coe, Lee Niel
OBJECTIVE To identify actions taken by owners to socialize puppies < 20 weeks of age, to determine factors affecting attendance of structured puppy classes, and to examine associations between class attendance and owner response to various undesirable puppy behaviors. DESIGN Cross-sectional study. SAMPLE 296 puppy owners (each with 1 puppy). PROCEDURES Participants completed a survey at enrollment (to gather data regarding owner demographics and puppy characteristics) and again when puppies were 20 weeks of age (to gather information on socialization practices and owner responses to misbehavior and signs of fear in their puppy)...
December 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29182955/individual-human-scent-as-a-forensic-identifier-using-mantrailing
#10
Leif Woidtke, Jan Dreßler, Carsten Babian
Specially trained dogs have long been used by law enforcement agencies to help in criminal investigations and in searching for missing persons. Still, it is unclear which components of human scent released into the environment contribute to successful searches of individuals. In this study, saliva and axillary sweat samples were taken from a total of 190 people. Additionally, DNA was extracted from whole blood of seven different people and used as an odour sample as well. Overall 675 tests (trails) were performed during a period of 18 months...
November 21, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29161455/responding-to-concerning-posts-on-social-media-insights-and-solutions-from-american-indian-and-alaska-native-youth
#11
Jesse Gritton, Stephanie Craig Rushing, David Stephens, Thomas Ghost Dog, Bradley Kerr, Megan A Moreno
PURPOSE: This study aimed to understand American Indian and Alaska Native (AI/AN) adolescents' perspectives on concerning social media posts, including those expressing suicidal intent. METHODS: A purposive sample of AI/AN youth were recruited; trained facilitators conducted focus groups. Participants discussed experiences viewing concerning posts on social media. Qualitative analysis used the constant comparative method. RESULTS: A total of 32 AI/AN youth ages 14-22 participated...
2017: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/29157032/pain-fatigue-function-and-participation-among-long-term-manual-wheelchair-users-partnered-with-a-mobility-service-dog
#12
Claude Vincent, Dany H Gagnon, Frédéric Dumont
PURPOSE: To assess the effects of a mobility service dog (MSD) on pain, fatigue, wheelchair-related functional tasks, participation and satisfaction among manual wheelchair users over a nine-month period. METHOD: A longitudinal study with repeated assessment times before and three, six and nine months after intervention was achieved. Intervention consisted in partnering each participant with a MSD. The setting is a well-established provincial service dog training school and participants homes...
November 20, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29152249/a-survey-of-feeding-activity-supplement-use-and-energy-consumption-in-north-american-agility-dogs
#13
Gina K Dinallo, Jennifer A Poplarski, Gretchen M Van Deventer, Laura A Eirmann, Joseph J Wakshlag
A survey was designed and administered at eighteen agility competitions across the Northeast and Midwest USA in 2015 to obtain information regarding competition level, training, feeding practices, owner-reported weight, body condition score (BCS) and supplement use. Average energy intake per d from reported consumption was assessed for all dogs in ideal body condition based on manufacturers' or US Department of Agriculture database information. To assess the respective parameters across competition levels (novice, open, master/elite), non-parametric or parametric ANOVA or χ(2) was used to determine significance...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29152237/analysis-of-recipes-of-home-prepared-diets-for-dogs-and-cats-published-in-portuguese
#14
Vivian Pedrinelli, Márcia de O S Gomes, Aulus C Carciofi
The present study evaluated recipes of home-prepared diets for dogs and cats published in Portuguese. A total of 106 diets were evaluated: eighty for dogs, twenty-four for cats and two intended for both species. A commercial software package was used to analyse the diets, and an ingredient chemical composition database was built based on the Brazilian Tables of Food Composition and United States Department of Agriculture Nutrient Database. The estimated chemical composition of each recipe was compared with the Nutritional Guidelines for Complete and Complementary Pet Food for Cats and Dogs (Fédération Européenne de L'industrie des Aliments Pour Animaux Familiers; FEDIAF, 2014) recommendations for maintenance (as units/MJ)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29134447/should-i-fetch-one-or-the-other-a-study-on-dogs-on-the-object-choice-in-the-bimodal-contrasting-paradigm
#15
Anna Scandurra, Alessandra Alterisio, Massimo Aria, Rosaria Vernese, Biagio D'Aniello
The present study assessed how dogs weigh gestural versus verbal information communicated to them by humans in transitive actions. The dogs were trained by their owners to fetch an object under three conditions: a bimodal congruent condition characterized by using gestures and voices simultaneously; a unimodal gestural condition characterized by using only gestures; and a unimodal verbal condition characterized by using only voices. An additional condition, defined as a bimodal incongruent condition, was later added, in which the gesture contrasted with the verbal command, that is, the owner indicated an object while pronouncing the name of the other object visible to dogs...
November 13, 2017: Animal Cognition
https://www.readbyqxmd.com/read/29116175/sniffer-mice-discriminate-urine-odours-of-patients-with-bladder-cancer-a-proof-of-principle-study-for-non-invasive-diagnosis-of-cancer-induced-odours
#16
Takaaki Sato, Yoji Katsuoka, Kimihiko Yoneda, Mitsuo Nonomura, Shinya Uchimoto, Reiko Kobayakawa, Ko Kobayakawa, Yoichi Mizutani
Similar to fingerprints, humans have unique, genetically determined body odours. In case of urine, the odour can change due to variations in diet as well as upon infection or tumour formation. We investigated the use of mice in a manner similar to "sniffer dogs" to detect changes in urine odour in patients with bladder cancer. We measured the odour discrimination thresholds of mice in a Y-maze, using urine mixtures from patients with bladder cancer (Stage I) and healthy volunteers (dietary variations) as well as occult blood- or antibiotic drug metabolite-modulated samples...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29111287/transcatheter-closure-of-a-small-atrial-septal-defect-with-an-amplatzer%C3%A2-patent-foramen-ovale-occluder-in-a-working-dog-with-cyanosis-and-exercise-intolerance-at-high-altitude
#17
A Shelden, S Wesselowski, S G Gordon, A B Saunders
A 6.5-year-old male Border Collie presented for transcatheter closure of an atrial septal defect due to exercise intolerance and cyanosis while working and training at altitude. A small, left-to-right shunting secundum atrial septal defect was confirmed with no evidence of significant right-sided volume overload. Pulmonary hypertension with subsequent right-to-left interatrial shunting occurring during exercise at high altitude was suspected and prompted the closure of the defect due to the dog's continued athletic requirements...
December 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29099318/motivation-and-prior-animal-experience-of-newly-enrolled-veterinary-nursing-students-at-two-irish-third-level-institutions
#18
Karen Dunne, Bernadette Brereton, Vivienne Duggan, Deirdre Campion
Veterinary nurses report an intrinsic desire to work with animals. However, this motivation may be eroded by poor working conditions and low pay, resulting in the exit of experienced veterinary nurses from clinical practice. This study sought to quantify the level of animal-handling experience students possessed at the start of their training and to explore the factors motivating them to enter veterinary nurse training in two Irish third-level institutions. The authors had noted a tendency for veterinary nursing students to possess limited animal-handling skills, despite their obvious motivation to work with animals...
November 3, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/29091047/instrumental-sensing-of-trace-volatiles-a-new-promising-tool-for-detecting-the-presence-of-entrapped-or-hidden-people
#19
Paweł Mochalski, Vera Ruzsanyi, Helmut Wiesenhofer, Christopher A Mayhew
There is a growing demand for rapid analytical systems for detecting the presence of humans who are either entrapped as a result of a disaster or in particular hidden, as in the case of smuggling or trafficking. The trafficking and smuggling of people to Europe have reached epidemic proportions in recent years. This does not only put a major strain on European resources, but puts at risk the health and lives of the people being trafficked or smuggled. In this context, the early detection and interception of smuggled/trafficked people is of particular importance in terms of saving migrants from life-threatening situations...
November 1, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29066245/effects-of-neostigmine-or-edrophonium-on-force-of-contraction-when-administered-at-a-train-of-four-ratio-of-0-9-in-anesthetized-dogs
#20
Marta Romano, Manuel Martin-Flores, Daniel M Sakai, Chia T Tseng, Luis Campoy, Robin D Gleed
OBJECTIVE: Anticholinesterase drugs may produce paradoxical neuromuscular block when administered at shallow levels of neuromuscular block. The objective of this study was to evaluate the effects of neostigmine and edrophonium when administered at near-complete reversal from nondepolarizing block in anesthetized dogs. STUDY DESIGN: Incomplete crossover, randomized, blinded experimental study. ANIMALS: A total of 12 Beagle dogs. METHODS: Each dog was anesthetized twice with propofol and maintained with isoflurane and dexmedetomidine...
August 3, 2017: Veterinary Anaesthesia and Analgesia
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