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https://www.readbyqxmd.com/read/27922860/the-impact-of-radiological-response-to-peptide-receptor-radionuclide-therapy-on-overall-survival-in-patients-with-metastatic-midgut-neuroendocrine-tumors
#1
Mehmet Yalchin, Amelia Oliveira, Eleni Theocharidou, Deborah Pencharz, Shaunak Navalkissoor, Ann-Marie Quigley, Martin Walker, Martyn Caplin, Christos Toumpanakis
PURPOSE OF THE REPORT: Peptide receptor radionuclide therapy (PRRT) is an effective treatment for advanced neuroendocrine tumors (NET); however, long-term survival data are scarce. The aim of this study is to determine long-term survival in patients with metastatic midgut NET, according to response to PRRT. PATIENTS AND METHODS: One hundred thirty-three consecutive patients with progressive metastatic midgut NET underwent PRRT. Response at 1 year post PRRT was classified as partial response, stable disease, disease progression, or death...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27922723/the-american-indian-and-alaska-native-dentist-workforce-in-the-united-states
#2
Elizabeth Mertz, Cynthia Wides, Paul Gates
OBJECTIVES: The purpose of this article is to describe the American Indian/Alaska Native (AI/AN) dentist workforce, the general practice patterns of these providers, and their contributions to oral health care for AI/AN and underserved patients. METHODS: A national sample survey of underrepresented minority dentists was conducted in 2012 and received a 34 percent response rate for self-reported AI/AN dentists. Data were weighted for selection and response bias to be nationally representative...
December 6, 2016: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/27922591/re-assessment-of-net-energy-production-and-greenhouse-gas-emissions-avoidance-after-40-years-of-photovoltaics-development
#3
Atse Louwen, Wilfried G J H M van Sark, André P C Faaij, Ruud E I Schropp
Since the 1970s, installed solar photovoltaic capacity has grown tremendously to 230 gigawatt worldwide in 2015, with a growth rate between 1975 and 2015 of 45%. This rapid growth has led to concerns regarding the energy consumption and greenhouse gas emissions of photovoltaics production. We present a review of 40 years of photovoltaics development, analysing the development of energy demand and greenhouse gas emissions associated with photovoltaics production. Here we show strong downward trends of environmental impact of photovoltaics production, following the experience curve law...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27922538/the-role-of-68ga-dota-noc-pet-ct-in-evaluating-neuroendocrine-tumors-real-world-experience-from-two-large-neuroendocrine-tumor-centers
#4
Mohamad Haidar, Ali Shamseddine, Emmanouil Panagiotidis, Mario Jreige, Deborah Mukherji, Rita Assi, Rayan Abousaid, Toni Ibrahim, Marwan M Haddad, Sobhan Vinjamuri
OBJECTIVE: Our aim was to assess the role of Ga-DOTA-NOC PET/CT as a tool for the management of neuroendocrine tumors (NETs), evaluating the clinical impact on patients from two large NET centers in different geopolitical settings. PATIENTS AND METHODS: This is a retrospective study of patients with NETs who underwent Ga-DOTA-NOC PET/CT at Royal Liverpool University Hospital (UK) and at Mount Lebanon Hospital (Lebanon). Indications for imaging and findings of the PET/CT along with demographic and clinical outcome data were recorded and evaluated...
December 2, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27922522/chronic-kidney-disease-predicts-coronary-plaque-vulnerability-an-optical-coherence-tomography-study
#5
Jiannan Dai, Lei Xing, Jingbo Hou, Haibo Jia, Sining Hu, Jinwei Tian, Lin Lin, Lulu Li, Yinchun Zhu, Gonghui Zheng, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
OBJECTIVE: The addition of cystatin C to creatinine in calculating the estimated glomerular filtration rate (eGFR) is known to improve the risk prediction for cardiovascular events. We sought to investigate the associations between eGFRs calculated by three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and coronary plaque phenotype by optical coherence tomography. PATIENTS AND METHODS: We analyzed 181 nonculprit plaques from 116 coronary artery disease patients...
December 2, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27922181/evaluation-of-gas-and-carbon-transport-in-a-methanogenic-bioelectrochemical-system-bes
#6
Christy M Dykstra, Spyros G Pavlostathis
Bioelectrochemical systems (BESs) may be used to upgrade anaerobic digester biogas by directly converting CO2 to CH4 .The objective of this study was to evaluate gas (N2 , CO2 , CH4 , and H2 ) and carbon transport within a methanogenic BES. Four BES configurations were evaluated: abiotic anode with abiotic cathode (AAn-ACa), bioanode with abiotic cathode (BAn-ACa), abiotic anode with biocathode (AAn-BCa), and bioanode with biocathode (BAn-BCa). Transport of N2 , a gas commonly used for flushing anoxic systems, out of the anode headspace ranged from 3...
December 6, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27922167/cost-effectiveness-of-primarily-surgical-versus-primarily-conservative-treatment-of-acute-and-subacute-radiculopathies-due-to-intervertebral-disc-herniation-from-the-swiss-perspective
#7
Zanfina Ademi, Viktoria Gloy, Dominik Glinz, Heike Raatz, Joris Van Stiphout, Heiner C Bucher, Matthias Schwenkglenks
AIMS OF THE STUDY: To assess the cost-effectiveness of primarily surgical treatment (PST) versus primarily conservative treatment (PCT) in adults with intermediate severity, acute or subacute, lumbar radicular syndrome due to intervertebral disc herniation. METHODS: A decision analytic model from healthcare system and societal perspectives was used to compare outcomes and costs of PST with those of PCT (physiotherapy, epidural injection and medication). Treatment pathways and quality of life were obtained from published clinical trials...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27921354/low-frequency-ch-stretch-vibrations-of-free-alkoxide-ions
#8
Jos Oomens, Giel Berden, Thomas Hellman Morton
CH stretches in hydrocarbon cations often shift to lower frequencies relative to neutral molecules, because they do not have sufficient electrons to give every bond an electron pair. A parallel effect in negatively charged species has not been previously observed. Here we show that CH bond weakening occurs in alkoxide anions as a consequence of hyperconjugation. The reasoning differs somewhat from the case of positively charged ions, but the net effect is the same: to lower CH stretching frequencies by hundreds of wavenumbers...
December 6, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27920776/immunodetection-of-nets-in-paraffin-embedded-tissue
#9
Volker Brinkmann, Ulrike Abu Abed, Christian Goosmann, Arturo Zychlinsky
The pathogenic potential of neutrophil extracellular traps (NETs) was recently described, and their detection in tissue could serve as a prognostic marker. NETs are delicate and filigree structures; hence good tissue preservation is essential for their detection. Indeed, analysis of paraffin-embedded tissue has proven superior to the study of cryo sections. Though, under favorable conditions, the presence of NETs can be detected in tissue sections stained with histological dyes, definitive identification of NETs needs the colocalization of immunofluorescent signals for both nuclear and granular (or cytoplasmic) NET components...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27920564/prioritizing-health-system-and-disease-burden-factors-an-evaluation-of-the-net-benefit-of-transferring-health-technology-interventions-to-different-districts-in-zimbabwe
#10
Shepherd Shamu, Simbarashe Rusakaniko, Charles Hongoro
INTRODUCTION: Health-care technologies (HCTs) play an important role in any country's health-care system. Zimbabwe's health-care system uses a lot of HCTs developed in other countries. However, a number of local factors have affected the absorption and use of these technologies. We therefore set out to test the hypothesis that the net benefit regression framework (NBRF) could be a helpful benefit testing model that enables assessment of intra-national variables in HCT transfer. METHOD: We used an NBRF model to assess the benefits of transferring cost-effective technologies to different jurisdictions...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27920547/predictive-value-of-nt-probnp-for-30-day-mortality-in-patients-with-non-st-elevation-acute-coronary-syndromes-a-comparison-with-the-grace-and-timi-risk-scores
#11
Dirk Aam Schellings, Ahmet Adiyaman, Jan-Henk E Dambrink, At Marcel Gosselink, Elvin Kedhi, Vincent Roolvink, Jan Paul Ottervanger, Arnoud Wj Van't Hof
BACKGROUND: The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts outcome in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). Whether NT-proBNP has incremental prognostic value beyond established risk strategies is still questionable. PURPOSE: To evaluate the predictive value of NT-proBNP for 30-day mortality over and beyond the Global Registry of Acute Coronary Events (GRACE) and Thrombolysis In Myocardial Infarction (TIMI) risk scores in patients with NSTE-ACS...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27920488/evalmsa-a-program-to-evaluate-multiple-sequence-alignments-and-detect-outliers
#12
Alvaro Chiner-Oms, Fernando González-Candelas
We present EvalMSA, a software tool for evaluating and detecting outliers in multiple sequence alignments (MSAs). This tool allows the identification of divergent sequences in MSAs by scoring the contribution of each row in the alignment to its quality using a sum-of-pair-based method and additional analyses. Our main goal is to provide users with objective data in order to take informed decisions about the relevance and/or pertinence of including/retaining a particular sequence in an MSA. EvalMSA is written in standard Perl and also uses some routines from the statistical language R...
2016: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/27920310/costs-and-savings-associated-with-community-water-fluoridation-in-the-united-states
#13
Joan O'Connell, Jennifer Rockell, Judith Ouellet, Scott L Tomar, William Maas
The most comprehensive study of US community water fluoridation program benefits and costs was published in 2001. This study provides updated estimates using an economic model that includes recent data on program costs, dental caries increments, and dental treatments. In 2013 more than 211 million people had access to fluoridated water through community water systems serving 1,000 or more people. Savings associated with dental caries averted in 2013 as a result of fluoridation were estimated to be $32.19 per capita for this population...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920243/between-the-flags-implementing-a-safety-net-system-at-scale-to-recognise-and-manage-deteriorating-patients-in-the-new-south-wales-public-health-system
#14
Charles Pain, Malcolm Green, Colette Duff, Deborah Hyland, Annette Pantle, Kimberley Fitzpatrick, Cliff Hughes
QUALITY PROBLEM: In 2005, the Clinical Excellence Commission (CEC) found that unrecognised patient deterioration remained an important problem in New South Wales (NSW) public hospitals. INITIAL ASSESSMENT: The challenge was to design and implement an effective and sustainable safety-net system in all 225 NSW public hospitals. DESIGNING A SOLUTION: The CEC's system was designed in collaboration with a broad coalition of partners, including clinicians, managers, system administrators and collaborating agencies...
December 4, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27919911/in-vitro-activation-of-coagulation-by-human-neutrophil-dna-and-histone-proteins-but-not-neutrophil-extracellular-traps
#15
Denis F Noubouossie, Matthew F Whelihan, Yuan-Bin Yu, Erica Sparkenbaugh, Rafal Pawlinski, Dougald M Monroe, Nigel S Key
NETosis is a physiological process in which neutrophils release their nuclear material in the form of neutrophil extracellular traps (NETs). NETs have been reported to directly promote thrombosis in animal models. Although the effects of purified NET components including DNA, histone proteins and neutrophil enzymes on coagulation have been characterized, the mechanism by which intact NETs promote thrombosis is largely unknown. In this study, human neutrophils were stimulated to produce NETs in platelet-free plasma (PFP) or in buffer using PMA or calcium ionophore...
December 5, 2016: Blood
https://www.readbyqxmd.com/read/27919740/metabolic-differences-between-cold-stored-and-machine-perfused-porcine-kidneys-a-1-h-nmr-based-study
#16
Jay Nath, Tom B Smith, Kamlesh Patel, Sam R Ebbs, Alex Hollis, Daniel A Tennant, Christian Ludwig, Andrew R Ready
Hypothermic machine perfusion (HMP) and static cold storage (SCS) are the two methods used to preserve deceased donor kidneys prior to transplant. This study seeks to characterise the metabolic profile of HMP and SCS porcine kidneys in a cardiac death donor model. Twenty kidneys were cold flushed and stored for two hours following retrieval. Paired kidneys then underwent 24 h of HMP or SCS or served as time zero controls. Metabolite quantification in both storage fluid and kidney tissue was performed using one dimensional (1)H NMR spectroscopy...
December 2, 2016: Cryobiology
https://www.readbyqxmd.com/read/27919574/worldwide-comparison-of-ovarian-cancer-survival-histological-group-and-stage-at-diagnosis-concord-2
#17
Melissa Matz, Michel P Coleman, Helena Carreira, Diego Salmerón, Maria Dolores Chirlaque, Claudia Allemani
OBJECTIVE: Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. METHODS: The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15-99years) diagnosed with ovarian cancer during 1995-2009...
December 2, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27919396/think-time-a-novel-approach-to-analysis-of-clinicians-behavior-after-reduction-of-drug-drug-interaction-alerts
#18
Richard Schreiber, Julia A Gregoire, Jacob E Shaha, Steven H Shaha
OBJECTIVES: Pharmacologic interaction alerting offers the potential for safer medication prescribing, but research reveals persistent concerns regarding alert fatigue. Research studies have tried various strategies to resolve this problem, with low overall success. We examined the effects of targeted alert reduction on clinician behavior in a resource constrained hospital. METHODS: A physician and a pharmacy informaticist reduced alert levels of several drug-drug interactions (DDI) that clinicians almost always overrode with approval from and knowledge of the medical staff...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919305/a-new-model-for-parent-of-origin-effect-analyses-applied-to-brown-swiss-cattle-slaughterhouse-data
#19
I Blunk, M Mayer, H Hamann, N Reinsch
Genomic imprinting is a phenomenon that arises when the expression of genes depends on the parental origin of alleles. Epigenetic mechanisms may induce the full or partial suppression of maternal or paternal alleles, thereby leading to different types of imprinting. However, imprinting effects have received little consideration in animal breeding programmes, although their relevance to some agricultural important traits has been demonstrated. A recently proposed model (imprinting model) with two path-of-transmission (male and female)-specific breeding values for each animal accounts for all types of imprinting simultaneously (paternal, maternal, full and partial)...
December 6, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27919257/global-priorities-for-research-and-the-relative-importance-of-different-research-outcomes-an-international-delphi-survey-of-malaria-research-experts
#20
Jo-Ann Mulligan, Lesong Conteh
BACKGROUND: As global research investment increases, attention inevitably turns to assessing and measuring the outcomes and impact from research programmes. Research can have many different outcomes such as producing advances in scientific knowledge, building research capacity and, ultimately, health and broader societal benefits. The aim of this study was to test the use of a Delphi methodology as a way of gathering views from malaria research experts on research priorities and eliciting relative valuations of the different types of health research impact...
December 6, 2016: Malaria Journal
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