M E Madeleine van der Perk, Nicholas G Cost, Annelies M E Bos, Robert Brannigan, Tanzina Chowdhury, Andrew M Davidoff, Najat C Daw, Jeffrey S Dome, Peter Ehrlich, Norbert Graf, James Geller, John Kalapurakal, Kathleen Kieran, Marcus Malek, Mary F McAleer, Elizabeth Mullen, Luke Pater, Angela Polanco, Rodrigo Romao, Amanda F Saltzman, Amy L Walz, Andrew D Woods, Marry M van den Heuvel-Eibrink, Conrad V Fernandez
The survival of childhood Wilms tumor is currently around 90%, with many survivors reaching reproductive age. Chemotherapy and radiotherapy are established risk factors for gonadal damage and are used in both COG and SIOP Wilms tumor treatment protocols. The risk of infertility in Wilms tumor patients is low but increases with intensification of treatment including the use of alkylating agents, whole abdominal radiation or radiotherapy to the pelvis. Both COG and SIOP protocols aim to limit the use of gonadotoxic treatment, but unfortunately this cannot be avoided in all patients...
September 15, 2022: International Journal of Cancer. Journal International du Cancer