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https://www.readbyqxmd.com/read/30007150/designing-for-online-computer-based-clinical-simulations-evaluation-of-instructional-approaches
#1
Ilana Dubovi
BACKGROUND: Online computer-based simulations are becoming more widespread in nursing education. Therefore, an understanding of when and how to implement the variety of instructional strategies related to these simulations is fundamental. OBJECTIVES: This study compares the effectiveness of online computer-based simulations designed using two alternative instructional approaches-Productive Failure and Simple-to-Complex sequencing-on learning of clinical reasoning skills...
July 6, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/30006784/metabolic-engineering-for-the-production-of-isoprene-and-isopentenol-by-escherichia-coli
#2
REVIEW
Meijie Li, Rui Nian, Mo Xian, Haibo Zhang
The biotechnological production of isoprene and isopentenol has recently been studied. Isoprene, which is currently made mainly from petroleum, is an important platform chemical for synthesizing pesticides, medicines, oil additives, fragrances, and more and is especially important in the rubber production industry. Isopentenols, which have better combustion properties than well-known biofuels (ethanol), have recently received more attention. Supplies of petroleum, the conventional source of isoprene and isopentenols, are unsustainable, and chemical synthesis processes could cause serious environmental problems...
July 14, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/30006768/ehealth-literacy-in-patients-with-cancer-and-their-usage-of-web-based-information
#3
Hanna Heiman, Christian Keinki, Jutta Huebner
OBJECTIVE: Our aim was to learn more about the association between the sources of information cancer patients and caregivers use and their eHealth literacy. METHODS: We distributed a standardized questionnaire among participants of a lecture program on complementary and alternative medicine (CAM). RESULTS: Among 182 attendants, the Internet was the third most important source of information (57%), preceded by the oncologist (67%) and print media (61%)...
July 13, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30006166/a-novel-anti-cancer-stem-cells-compound-optimized-from-the-natural-symplostatin-4-scaffold-inhibits-wnt-%C3%AE-catenin-signaling-pathway
#4
Shuangwei Liu, Xian Gao, Lisong Zhang, Shuanglin Qin, Mingming Wei, Ning Liu, Rui Zhao, Benlong Li, Ye Meng, Gang Lin, Cheng Lu, Xinhua Liu, Maodun Xie, Tongtong Liu, Honggang Zhou, Min Qi, Guang Yang, Cheng Yang
Cancer stem cells (CSCs) are responsible for carcinogenesis, cancer progression, relapse, metastasis and drug resistance. Therefore, the development of drug molecules targeting CSCs plays a vital role in medicinal researching field. However, there are extremely rare molecules that selectively ablate CSCs. The research and development of drugs targeting CSCs is limited due to a lack of anti-CSCs lead compounds. In this study, an anti-CSCs lead compound 35b was discovered, which was derived from the natural chemical scaffold of Symplostatin 4...
June 20, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30005571/affimers-as-an-alternative-to-antibodies-in-an-affinity-lc-ms-assay-for-quantification-of-the-soluble-receptor-of-advanced-glycation-end-products-srage-in-human-serum
#5
Frank Klont, Marrit Hadderingh, Péter Horvatovich, Nick H T Ten Hacken, Rainer Bischoff
Antibodies are indispensable tools in biomedical research, but their size, complexity, and sometimes lack of reproducibility created a need for the development of alternative binders to overcome these limitations. Affimers are a novel class of affinity binders based on a structurally robust protease inhibitor scaffold (i.e. Cystatin A), which are selected by phage display and produced in a rapid and simple E. coli protein expression system. These binders have a defined amino acid sequence with defined binding regions and are versatile thereby allowing for easy engineering...
July 13, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/30005079/efficacy-of-hank-s-balanced-salt-solution-compared-to-other-solutions-in-the-preservation-of-the-periodontal-ligament-a-systematic-review-and-meta-analysis
#6
Nathalia Carolina Fernandes Fagundes, Leonardo Oliveira Bittencourt, Marcela Baraúna Magno, Márcia Martins Marques, Lucianne Cople Maia, Rafael Rodrigues Lima
This systematic review and meta-analysis (MA) aimed to verify the capacity of different storage media to preserve viability of periodontal ligament cells in comparison to Hank's Balanced Salt Solution. The searches, selection process, data extraction and Risk of Bias control were conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Five MA were conducted to compare the cell viability between milk versus Hank's balanced salt solution (HBSS) in a dichotomous (1) or continuous (2) data model; tap water versus HBSS (3); medicinal herbals versus HBSS (4); and saline solution versus HBSS (5)...
2018: PloS One
https://www.readbyqxmd.com/read/30004605/repurposing-the-cord-blood-bank-for-haplobanking-of-hla-homozygous-ipscs-and-their-usefulness-to-multiple-populations
#7
Suji Lee, Ji Young Huh, David M Turner, Soohyeon Lee, James Robinson, Jeremy E Stein, Sung Han Shim, Chang Pyo Hong, Myung Seo Kang, Masato Nakagawa, Shin Kaneko, Mahito Nakanishi, Mahendra S Rao, Andreas Kurtz, Glyn N Stacey, Steven G E Marsh, Marc L Turner, Jihwan Song
Although autologous induced pluripotent stem cells (iPSCs) can potentially be useful for treating patients without immune rejection, in reality it will be extremely expensive and labor-intensive to make iPSCs to realize personalized medicine. An alternative approach is to make use of human leukocyte antigen (HLA) haplotype homozygous donors to provide HLA matched iPSC products to significant numbers of patients. In order to establish a haplobank of iPSCs, we repurposed the cord blood bank by screening ~4,200 high resolution HLA typed cord blood samples, and selected those homozygous for the ten most frequent HLA-A,-B,-DRB1 haplotypes in the Korean population...
July 13, 2018: Stem Cells
https://www.readbyqxmd.com/read/30002716/expression-of-concern-on-modes-of-antiviral-action-of-chemical-portions-and-constituents-from-woad-root-extract-against-influenza-virus-a-fm1
#8
Evidence-Based Complementary And Alternative Medicine
No abstract text is available yet for this article.
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30002398/antitumor-and-immunomodulatory-activities-of-total-flavonoids-extract-from-persimmon-leaves-in-h-22-liver-tumor-bearing-mice
#9
Li Chen, Yundong Wei, Shimei Zhao, Mengliang Zhang, Xiaoting Yan, Xiangyun Gao, Jinxia Li, Yutong Gao, Anwen Zhang, Ying Gao
Persimmon (Diospyros kaki L.) leaves are commonly used in Asia as tea infusion and as an agent in traditional medicine. The present study aims to explore the antitumor and immunomodulatory effects of total flavonoids extract from persimmon leaves (PLF) in H22 liver tumor-bearing mice. We found that the PLF showed significant inhibition on the liver tumor growth in mice with a tumor inhibition rate of up to 49.35%. In contrast to the severe side effects of cyclophosphamide (CTX), the PLF exhibited anti-cachexia effect and showed no alternation in the body weight and food intake in mice...
July 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29999539/synthesis-of-three-triterpene-series-and-their-activity-against-respiratory-syncytial-virus
#10
Gloria N Santos da Silva, Diana Monti Atik, Jheini L Antunes Fernandes, Deise de Freitas do Nascimento, Tiago Fazolo, Ana Paula Duarte de Souza, Simone C Baggio Gnoatto
The human respiratory syncytial virus (hRSV) is a leading cause of hospitalization due to acute lower respiratory infection especially in infants and young children, sometimes causing fatal cases. The monoclonal antibody palivizumab is one of the available options for preventing this virus, and at the moment there are several hRSV vaccine trials underway. Unfortunately, the only drug option to treat hRSV infection is ribavirin, which can be used in severe high-risk cases. For this reason, new medicines are needed and, in this context, the triterpenes and their derivatives are promising alternatives, since many of them have shown important antiviral activity, such as bevirimat...
July 12, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29997735/acute-cardiometabolic-responses-to-medicine-ball-interval-training-in-children
#11
Avery D Faigenbaum, Jie Kang, Nicholas A Ratamess, Anne Farrell, Nicole Ellis, Ira Vought, Jill Bush
Medicine ball interval training (MBIT) has been found to be an effective exercise modality in fitness programs, yet the acute physiological responses to this type of this exercise in youth are unknown. The purpose of this study was to examine the acute cardiometabolic responses to MBIT in children. Fourteen children (mean age 10.1 ± 1.3 yr) were tested for peak oxygen uptake (VO2 peak) on a treadmill and subsequently (> 48 hours later) performed a progressive 10 min MBIT protocol of 5 exercises (EX): standing marches (EX1), alternating lunges (EX2), squat swings (EX3), chest passes (EX4) and double arm slams (EX5)...
2018: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29997685/combination-of-salvia-miltiorrhiza-and-ligustrazine-attenuates-bleomycin-induced-pulmonary-fibrosis-in-rats-via-modulating-tnf-%C3%AE-and-tgf-%C3%AE
#12
Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang, Xianming Fan
Background: Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side effects. Recently, combination of two Chinese herbal medicine preparations, Salvia miltiorrhiza and ligustrazine (SML), serves as an alternative medicine for treatment of IPF in clinical practices in China...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29995826/effects-of-pharmacopuncture-with-wild-ginseng-complex-in-2-elderly-patients-with-obesity-case-report
#13
Ji Hye Hwang, Hyo Won Jung
RATIONALE: Obesity has become a worldwide health challenge. In elderly patients, obesity induces a decrease in skeletal muscle strength and mass, which is linked to age-related sarcopenia. These are important predictors of hospitalization and death. Herein, we report on 2 elderly male patients who were treated by pharmacopuncture with wild ginseng complex (WGC). PATIENT CONCERNS: Case 1 was that of a 62-year-old man who was mainly concerned about his appearance as his abdominal fat was steadily increasing, without any changes to his body weight...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29995135/identification-and-mapping-of-real-acupoints-in-the-anatomical-topography-of-boa-constrictor
#14
T M Fernandes, F C Lopes, G C O M Santana, M K S Oliveira, M O Freitas, C I A Freitas
Acupuncture is a therapy of the traditional Chinese medicine technique, which over the years has been widespread in the West. Defined as a needle-point treatment technique (acupoints), exactly preconfigured in the body to produce a specific physiological reaction to restore the balance between the function of conflicting states and homeostasis, alternating states of energy and thus maintain the ideal organ and body organization. Thus, the objective of this study was to map and describe the main points of acupuncture in the species Boa constrictor , and their indications to promote the balance of this species...
July 10, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29993171/ghanaian-traditional-and-faith-healers-explanatory-models-of-intellectual-disability
#15
Lily Kpobi, Leslie Swartz
BACKGROUND: The use of traditional/alternative medicine for health care in Africa has been examined for various conditions. However, there is limited research about traditional/alternative health care for intellectual disability. The present authors explored the explanatory models (EMs) of intellectual disability held by traditional/faith healers in Ghana. METHODS: Using a case vignette, the present authors conducted semi-structured interviews with 36 traditional/faith healers in Accra, Ghana...
July 11, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29992672/dienogest-therapy-during-the-early-stages-of-recurrence-of-endometrioma-might-be-an-alternative-therapeutic-option-to-avoid-repeat-surgeries
#16
Akemi Koshiba, Taisuke Mori, Hiroyuki Okimura, Kanoko Akiyama, Hisashi Kataoka, Osamu Takaoka, Fumitake Ito, Hiroshi Matsushima, Izumi Kusuki, Jo Kitawaki
AIM: We aimed to evaluate whether hormonal therapy immediately after postsurgical recurrence of ovarian endometrioma controls disease progression and can be an alternative therapeutic option to avoid multiple repeat surgeries. METHODS: We enrolled 146 patients treated for endometrioma at the University Hospital of Kyoto Prefectural University of Medicine between 2009 and 2015. After laparoscopic cystectomy using the stripping technique, opening of cul-de-sac obliterations and complete resection of the deep infiltrating endometriosis lesions, the patients either received no treatment (n = 83), oral contraceptives (OC; n = 32) or dienogest (DNG; n = 27), depending on their medical history...
July 10, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29992169/health-literacy-status-and-understanding-of-the-prescription-instructions-in-diabetic-patients
#17
Shivangini Singh, Sahana Devadasa Acharya, Ashwin Kamath, Sheetal D Ullal, Rathnakar P Urval
This study aimed to assess the health literacy (HL) of patients having diabetes mellitus, their understanding of prescription instructions (PI), and the correlation between HL and understanding of PI. A cross-sectional survey was conducted in 263 adult diabetic patients who were assessed for their understanding of route of intake of the prescribed medication(s), frequency of intake, number of medication(s) to be consumed each time, indication for the medication(s), and the relation of drug intake with food...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29992106/herbal-remedies-for-liver-fibrosis-a-review-on-the-mode-of-action-of-fifty-herbs
#18
REVIEW
Uzma Latief, Riaz Ahmad
Liver fibrosis is a dynamic pathological condition which can be slowed down in its initial phases. Without proper clinical management of fibrosis, progressive liver damage may lead to cirrhosis and ultimately to liver failure or primary liver cancer, which are irreversible conditions. Therefore, in order to cure fibrotic damage to liver, its early stages should be the centre of attention. In this context, some supplements and 'complementary and alternative medicine (CAM)' deserve specific mention, because of their already recognized natural way of healing and long lasting curative effects...
July 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29991449/protostemonine-attenuates-alternatively-activated-macrophage-and-dra-induced-asthmatic-inflammation
#19
Yunduan Song, Yaxian Wu, Xiaozong Li, Yao Shen, Yunhe Ding, Hongbo Zhu, Fangfang Liu, Kaikai Yu, Lei Sun, Feng Qian
Asthma is one of the most common pulmonary diseases that threatens human life because of lack of effective medicines. Protostemonine (PSN), an active alkaloid extracted from the roots of Stemona sesslifolia, has anti-inflammatory effects on acute lung injury and acute liver failure. However, it has not been defined whether PSN alleviates asthmatic inflammation. Here, we reported that PSN inhibits pulmonary eosinophil infiltration, goblet cell hyperplasia, mucus secretion, IgE and Th2 cytokine (IL-4, IL-5, IL-13 and IL-33) production by using DRA (dust mites, ragweed and aspergillus)-induced murine asthma model...
July 2, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29991439/polysomnography-for-obstructive-sleep-apnea-should-include-arousal-based-scoring-an-american-academy-of-sleep-medicine-position-statement
#20
Raman K Malhotra, Douglas B Kirsch, David A Kristo, Eric J Olson, Rashmi N Aurora, Kelly A Carden, Ronald D Chervin, Jennifer L Martin, Kannan Ramar, Carol L Rosen, James A Rowley, Ilene M Rosen
The diagnostic criteria for obstructive sleep apnea (OSA) in adults, as defined in the International Classification of Sleep Disorders, Third Edition, requires an increased frequency of obstructive respiratory events demonstrated by in-laboratory, attended polysomnography (PSG) or a home sleep apnea test (HSAT). However, there are currently two hypopnea scoring criteria in The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications (AASM Scoring Manual). This dichotomy results in differences among laboratory reports, patient treatments and payer policies...
July 6, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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