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https://www.readbyqxmd.com/read/29780667/modulation-of-transcriptional-activity-in-brain-lower-grade-glioma-by-alternative-splicing
#1
Jin Li, Yang Wang, Xianglian Meng, Hong Liang
Proteins that modify the activity of transcription factors (TFs) are often called modulators and play a vital role in gene transcriptional regulation. Alternative splicing is a critical step of gene processing, and differentially spliced isoforms may have different functions. Alternative splicing can modulate gene function by adding or removing certain protein domains and thereby influence the activity of a protein. The objective of this study is to investigate the role of alternative splicing in modulating the transcriptional regulation in brain lower grade glioma (LGG), especially transcription factor ELK1, which is closely related to various disorders, including Alzheimer's disease and Down syndrome...
2018: PeerJ
https://www.readbyqxmd.com/read/29755716/automatic-semantic-segmentation-of-brain-gliomas-from-mri-images-using-a-deep-cascaded-neural-network
#2
Shaoguo Cui, Lei Mao, Jingfeng Jiang, Chang Liu, Shuyu Xiong
Brain tumors can appear anywhere in the brain and have vastly different sizes and morphology. Additionally, these tumors are often diffused and poorly contrasted. Consequently, the segmentation of brain tumor and intratumor subregions using magnetic resonance imaging (MRI) data with minimal human interventions remains a challenging task. In this paper, we present a novel fully automatic segmentation method from MRI data containing in vivo brain gliomas. This approach can not only localize the entire tumor region but can also accurately segment the intratumor structure...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29752587/probiotics-for-respiratory-tract-infections-in-children-attending-day-care-centers-a-systematic-review
#3
REVIEW
Rikke Pilmann Laursen, Iva Hojsak
Probiotics have been suggested to have a preventive effect on respiratory tract infections (RTIs), but limited evidence exist on strain-specific effects. The main aim of this systematic review and meta-analysis was to evaluate strain-specific probiotic effects on RTIs in children attending day care. We included 15 RCTs with 5121 children in day care settings (aged 3 months to 7 years), but due to high diversity in reported outcomes, different number of RCTs were available for evaluated outcomes. Twelve RCTs (n = 4527) reported results which could be compared in at least one outcome of the meta-analysis...
May 12, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29750399/single-agent-bevacizumab-in-the-treatment-of-recurrent-or-refractory-pediatric-low-grade-glioma-a-single-institutional-experience
#4
Hamza S Gorsi, Paritosh C Khanna, Mark Tumblin, Lanipua Yeh-Nayre, Mehrzad Milburn, Jennifer D Elster, John R Crawford
INTRODUCTION: Bevacizumab-based therapy has been demonstrated to be effective in the treatment of refractory or recurrent pediatric low-grade glioma (LGG); however its efficacy as a single agent is less understood. METHODS: We report our experience with single-agent bevacizumab for the treatment of recurrent or refractory LGG treated with either standard 2 week dosing (10 mg/kg/dose every 2 weeks) or with a standard 2 week dosing followed by an increased interval dosing (10 mg/kg/dose every 4 weeks)...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29734688/skin-protective-nutraceuticals-the-current-evidence-in-brief
#5
Oroma Nwanodi
Nutraceuticals are important for healthy skin maintenance. Probiotics, phenolics, and vitamins are just a few of the nutraceuticals meant to potentially prevent and assist medical management of dermatologic conditions. Among these, probiotics, vitamin E, and green tea catechins may offer the broadest array of skin protective mechanisms with probiotics having the greatest clinical range. Probiotics’ amelioration of atopic dermatitis and opportunistic infections of skin burns has been targeted in recent research efforts...
May 4, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29733378/assessing-the-predictability-of-idh-mutation-and-mgmt-methylation-status-in-glioma-patients-using-relaxation-compensated-multi-pool-cest-mri-at-7-0-tesla
#6
Daniel Paech, Johannes Windschuh, Johanna Oberhollenzer, Constantin Dreher, Felix Sahm, Jan-Eric Meissner, Steffen Goerke, Patrick Schuenke, Moritz Zaiss, Sebastian Regnery, Sebastian Bickelhaupt, Philipp Bäumer, Martin Bendszus, Wolfgang Wick, Andreas Unterberg, Peter Bachert, Mark Edward Ladd, Heinz-Peter Schlemmer, Alexander Radbruch
Background: Early identification of prognostic superior characteristics in glioma patients such as Isocitrate dehydrogenase(IDH)-mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promotor methylation status is of great clinical importance. The study purpose was to investigate the non-invasive predictability of IDH-mutation status, MGMT promotor methylation, and differentiation of lower versus higher grade glioma (LGG vs. HGG) in newly-diagnosed patients employing relaxation-compensated multi-pool Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) at 7...
May 4, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29732524/integrated-analysis-of-dynamic-fet-pet-ct-parameters-histology-and-methylation-profiling-of-44-gliomas
#7
Manuel Röhrich, Kristin Huang, Daniel Schrimpf, Nathalie L Albert, Thomas Hielscher, Andreas von Deimling, Ulrich Schüller, Antonia Dimitrakopoulou-Strauss, Uwe Haberkorn
PURPOSE: Dynamic 18 F-FET PET/CT is a powerful tool for the diagnosis of gliomas.18 F-FET PET time-activity curves (TAC) allow differentiation between histological low-grade gliomas (LGG) and high-grade gliomas (HGG). Molecular methods such as epigenetic profiling are of rising importance for glioma grading and subclassification. Here, we analysed dynamic 18 F-FET PET data, and the histological and epigenetic features of 44 gliomas. METHODS: Dynamic 18 F-FET PET was performed in 44 patients with newly diagnosed, untreated glioma: 10 WHO grade II glioma, 13 WHO grade III glioma and 21 glioblastoma (GBM)...
May 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29729273/over-expression-of-lysyl-oxidase-is-associated-with-poor-prognosis-and-response-to-therapy-of-patients-with-lower-grade-gliomas
#8
Shang-Pen Huang, Jean Chiou, Yi-Hua Jan, Tsung-Ching Lai, Yung-Luen Yu, Michael Hsiao, Yuan-Feng Lin
Lower grade gliomas (LGGs) have highly diverse clinical phenotypes. The histological grade and type are insufficient to accurately predict the clinical outcomes of patients with LGGs. Therefore, identification of biomarkers that can facilitate the prediction of clinical outcomes in LGGs is urgently needed. Gene expression of LOX has been identified as a biomarker for various cancers. However, the clinical significance of LOX expression in LGGs has not been investigated. In this study, we analyzed the glioma RNA-seq dataset from TCGA (The Cancer Genome atlas) and identified lysyl oxidase (LOX) as a potential biomarker for LGGs...
May 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29706325/the-effect-of-pectins-on-survival-of-probiotic-lactobacillus-spp-in-gastrointestinal-juices-is-related-to-their-structure-and-physical-properties
#9
Nadja Larsen, Thiago Barbosa Cahú, Susana Marta Isay Saad, Andreas Blennow, Lene Jespersen
Pectins are plant polysaccharides used in food industry as gelling and stabilizing agents. This study investigated the ability of pectins to improve survival of probiotic species Lactobacillus fermentum PCC, L. reuteri RC-14, L. rhamnosus LGG and L. paracasei F-19 in simulated gastric solution in relationship to their structural and physical properties. Electrostatic interactions between pectins and bacteria were evaluated by the Zeta-potential approach. Bacterial survival was assessed by flow cytometry and plate counting...
September 2018: Food Microbiology
https://www.readbyqxmd.com/read/29692770/modulation-of-active-gut-microbiota-by-lactobacillus-rhamnosus-gg-in-a-diet-induced-obesity-murine-model
#10
Yosep Ji, Soyoung Park, Haryung Park, Eunchong Hwang, Hyeunkil Shin, Bruno Pot, Wilhelm H Holzapfel
Gut microbiota play a key role in the development of metabolic disorders. Defining and correlating structural shifts in gut microbial assemblages with conditions related to metabolic syndrome have, however, been proven difficult. Results from 16S genomic DNA and 16S ribosomal RNA analyses of fecal samples may differ widely, leading to controversial information on the whole microbial community and metabolically active microbiota. Using a C57BL/6J murine model, we compared data from 16S genomic DNA and ribosomal RNA of the fecal microbiota...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29682064/awake-craniotomy-with-noninvasive-brain-mapping-by-3-tesla-functional-magnetic-resonance-imaging-for-excision-of-low-grade-glioma-a-case-of-a-young-patient-from-pakistan
#11
Atta Ul Aleem Bhatti, Nasir Khan Jakhrani, Maria Adnan Parekh
The past few years have seen increasing support for gross total resection in the management of low-grade gliomas (LGGs), with a greater extent of resection correlated with better overall survival, progression-free survival, and time to malignant transformation. There is consistent evidence in literature supporting extent of safe resection as a good prognostic indicator as well as positively affecting seizure control, symptomatic relief in pressure symptoms, and longer progression-free and total survival. The operative goal in most LGG cases is to maximize the extent of resection for these benefits while avoiding postoperative neurologic deficits...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675474/brain-tumor-characterization-using-multibiometric-evaluation-of-mri
#12
Faris Durmo, Jimmy Lätt, Anna Rydelius, Silke Engelholm, Sara Kinhult, Krister Askaner, Elisabet Englund, Johan Bengzon, Markus Nilsson, Isabella M Björkman-Burtscher, Thomas Chenevert, Linda Knutsson, Pia C Sundgren
The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), cerebral blood volume (CBV), fractional anisotropy, and apparent diffusion coefficient maps used for quantification of magnetic resonance biometrics by manual delineation of regions of interest...
March 2018: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29658967/identification-of-microrna-signature-in-different-pediatric-brain-tumors
#13
Marwa Tantawy, Mariam G Elzayat, Dina Yehia, Hala Taha
Understanding pediatric brain tumor biology is essential to help on disease stratification, and to find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked to clinical outcomes and tumor biology. Here, we aimed to detect the expression of different miRNAs in different pediatric brain tumor subtypes to discover biomarkers for early detection and develop novel therapies. Expression of 82 miRNAs was detected in 120 pediatric brain tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade glioma, ependymoma, and medulloblastoma, using quantitative real-time PCR...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29626719/adhesive-interactions-between-milk-fat-globule-membrane-and-lactobacillus-rhamnosus-gg-inhibit-bacterial-attachment-to-caco-2-tc7-intestinal-cell
#14
Justine Guerin, Claire Soligot, Jennifer Burgain, Marion Huguet, Gregory Francius, Sofiane El-Kirat-Chatel, Faustine Gomand, Sarah Lebeer, Yves Le Roux, Frederic Borges, Joël Scher, Claire Gaiani
Milk is the most popular matrix for the delivery of lactic acid bacteria, but little is known about how milk impacts bacterial functionality. Here, the adhesion mechanisms of Lactobacillus rhamnosus GG (LGG) surface mutants to a milk component, the milk fat globule membrane (MFGM), were compared using atomic force microscopy (AFM). AFM results revealed the key adhesive role of the LGG SpaCBA pilus in relation to MFGM. A LGG mutant without exopolysaccharides but with highly exposed pili improved the number of adhesive events between LGG and MFGM compared to LGG wild type (WT)...
March 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29625306/low-grade-glioma-of-the-neurohypophysis-clinical-characteristics-and-surgical-outcomes
#15
Yuichi Nagata, Naoko Inoshita, Noriaki Fukuhara, Mitsuo Yamaguchi-Okada, Hiroshi Nishioka, Shozo Yamada
BACKGROUND: Low-grade glioma (LGG) of the neurohypophysis is an extremely rare tumor arising from the pituicytes of the posterior pituitary or the infundibulum. The preoperative imaging findings of these tumors mimic those of pituitary adenomas, and radical resection is often challenging in affected patients due to the hypervascularity of the tumor. Here, we describe the clinical and radiological features of this clinical entity. METHODS: We identified 8 patients with LGG of the neurohypophysis...
April 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29624154/the-diagnostic-accuracy-of-detecting-malignant-transformation-of-low-grade-glioma-using-o-2-18-f-fluoroethyl-l-tyrosine-positron-emission-tomography-a-retrospective-study
#16
Asma Bashir, Jannick Brennum, Helle Broholm, Ian Law
OBJECTIVE The diagnostic accuracy of O-(2-[18 F]fluoroethyl)-l-tyrosine (FET) PET scanning in detecting the malignant transformation of low-grade gliomas (LGGs) is controversial. In this study, the authors retrospectively assessed the diagnostic potential of FET PET in patients with MRI-suspected malignant progression of LGGs that had previously been treated and the relationship between FET uptake and MRI and molecular biomarkers. METHODS Forty-two patients who had previously undergone surgical or multimodal treatment for a histologically verified LGG were referred for FET PET assessment because of clinical signs and/or MRI findings suggestive of tumor progression...
April 6, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29618666/peptide-vaccine-immunotherapy-biomarkers-and-response-patterns-in-pediatric-gliomas
#17
Sören Müller, Sameer Agnihotri, Karsen E Shoger, Max I Myers, Nicholas Smith, Srilakshmi Chaparala, Clarence R Villanueva, Ansuman Chattopadhyay, Adrian V Lee, Lisa H Butterfield, Aaron Diaz, Hideho Okada, Ian F Pollack, Gary Kohanbash
Low-grade gliomas (LGGs) are the most common brain tumor affecting children. We recently reported an early phase clinical trial of a peptide-based vaccine, which elicited consistent antigen-specific T cell responses in pediatric LGG patients. Additionally, we observed radiologic responses of stable disease (SD), partial response (PR), and near-complete/complete response (CR) following therapy. To identify biomarkers of clinical response in peripheral blood, we performed RNA sequencing on PBMC samples collected at multiple time points...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29590424/the-t2-flair-mismatch-sign-as-an-imaging-marker-for-non-enhancing-idh-mutant-1p-19q-intact-lower-grade-glioma-a-validation-study
#18
Martinus P G Broen, Marion Smits, Maarten M J Wijnenga, Hendrikus J Dubbink, Monique H M E Anten, Olaf E M G Schijns, Jan Beckervordersandforth, Alida A Postma, Martin J van den Bent
Background: The purpose of this study was to assess the reproducibility of the previously described T2-FLAIR mismatch sign as a specific imaging marker in non-enhancing isocitrate dehydrogenase (IDH) mutant, 1p/19q non-codeleted lower grade glioma (LGG), encompassing both diffuse and anaplastic astrocytoma. Methods: MR scans (n=154) from three separate databases with genotyped LGG were evaluated by two independent reviewers to assess (i) presence/absence of "T2-FLAIR mismatch" sign and (ii) presence/absence of homogenous signal on T2WI...
March 26, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29577335/evaluation-of-postharvest-calcium-treatment-and-biopreservation-with-lactobacillus-rhamnosus-gg-on-the-quality-of-fresh-cut-conference-pears
#19
Lorena Zudaire, Inmaculada Viñas, Lucía Plaza, María Belén Iglesias, Maribel Abadias, Ingrid Aguiló-Aguayo
BACKGROUND: Biological preservation with probiotic bacteria has arisen as an alternative to control the growth of foodborne pathogens on food. The objective of this work was to evaluate the effect of postharvest calcium application and biopreservation with Lactobacillus rhamnosus GG on the quality and bioaccessibility of total phenolic content and antioxidant activity in fresh-cut pears. RESULTS: The immersion of whole pears in a calcium chloride solution did not provide added value...
March 25, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29573085/radiomics-strategy-for-glioma-grading-using-texture-features-from-multiparametric-mri
#20
Qiang Tian, Lin-Feng Yan, Xi Zhang, Xin Zhang, Yu-Chuan Hu, Yu Han, Zhi-Cheng Liu, Hai-Yan Nan, Qian Sun, Ying-Zhi Sun, Yang Yang, Ying Yu, Jin Zhang, Bo Hu, Gang Xiao, Ping Chen, Shuai Tian, Jie Xu, Wen Wang, Guang-Bin Cui
BACKGROUND: Accurate glioma grading plays an important role in the clinical management of patients and is also the basis of molecular stratification nowadays. PURPOSE/HYPOTHESIS: To verify the superiority of radiomics features extracted from multiparametric MRI to glioma grading and evaluate the grading potential of different MRI sequences or parametric maps. STUDY TYPE: Retrospective; radiomics. POPULATION: A total of 153 patients including 42, 33, and 78 patients with Grades II, III, and IV gliomas, respectively...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
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