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https://www.readbyqxmd.com/read/29129767/low-grade-glioma-with-foci-of-early-transformation-does-not-necessarily-require-adjuvant-therapy-following-radical-surgical-resection
#1
Y Z Al-Tamimi, M S Palin, T Patankar, J MacMullen-Price, D J O'Hara, C Loughrey, A Chakrabarty, A Ismail, P Roberts, H Duffau, J R Goodden, P D Chumas
BACKGROUND: Low-grade glioma (LGG) is a slow-growing tumour often found in young adults with minimal or no symptoms. As opposed to true 'low-grade' lesions like dysembryoplastic neuroepithelial tumours (DNETs), they are associated with continuous growth and inevitable malignant transformation. METHOD: Case series of patients who have had en-bloc resection of low-grade glioma with foci of anaplasia found within embedded within the tumour specimen and not at margins...
November 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29128317/lack-of-efficacy-of-lactobacillus-gg-in-reducing-pulmonary-exacerbations-and-hospital-admissions-in-children-with-cystic-fibrosis-a-randomised-placebo-controlled-trial
#2
Eugenia Bruzzese, Valeria Raia, Eliana Ruberto, Riccardo Scotto, Antonietta Giannattasio, Dario Bruzzese, Maria Cristina Cavicchi, Michela Francalanci, Carla Colombo, Nadia Faelli, Valeria Daccò, Giuseppe Magazzù, Stefano Costa, Vincenzina Lucidi, Fabio Majo, Alfredo Guarino
BACKGROUND: Intestinal dysbiosis has been described in Cystic Fibrosis (CF) and probiotics have been proposed to restore microbial composition. Aim of the study was to investigate the effects of Lactobacillus rhamnosus GG (LGG) on clinical outcomes in children with cystic fibrosis (CF). METHODS: A multicentre, randomised double-blind, clinical trial was conducted in children with CF. After 6months of baseline assessment, enrolled children (2 to 16years of age) received Lactobacillus GG (6×10(9)CFU/day) or placebo for 12months...
November 8, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29121411/probiotic-lactobacillus-rhamnosus-gg-prevents-alveolar-bone-loss-in-a-mouse-model-of-experimental-periodontitis
#3
Simona M Gatej, Victor Marino, Richard Bright, Tracy R Fitzsimmons, Neville Gully, Peter Zilm, Rachel J Gibson, Suzanne Edwards, Peter M Bartold
AIM: This study investigated the role of Lactobacillus rhamnosus GG on bone loss and local and systemic inflammation in an in vivo mouse model of experimental periodontitis. MATERIALS AND METHODS: Experimental periodontitis was induced in mice by oral inoculation with Porphyromonas gingivalis and Fusobacterium nucleatum over a period of 44 days. The probiotic LGG was administered via oral inoculation or oral gavage prior to, and during disease induction. The antimicrobial activity of LGG on the inoculum was also tested...
November 9, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29105390/dual-effects-of-cell-free-supernatants-from-lactobacillus-acidophilus-and-lactobacillus-rhamnosus-gg-in-regulation-of-mmp-9-by-up-regulating-timp-1-and-down-regulating-cd147-in-pmadifferentiated-thp-1-cells
#4
Faezeh Maghsood, Abbas Mirshafiey, Mohadese M Farahani, Mohammad Hossein Modarressi, Parvaneh Jafari, Elahe Motevaseli
OBJECTIVES: Recent studies have reported dysregulated expression of matrix metalloproteinases (MMPs), especially MMP-2, MMP-9, tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, TIMP-2), and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in activated macrophages of patients with inflammatory diseases. Therefore, MMP-2, MMP-9, and their regulators may represent a new target for treatment of inflammatory diseases. Probiotics, which are comprised of lactic acid bacteria, have the potential to modulate inflammatory responses...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105013/is-non-awake-surgery-for-supratentorial-adult-low-grade-glioma-treatment-still-feasible
#5
REVIEW
Hugues Duffau
In this short review, the author performs a database search, summarizes, and discusses studies that provide information on the need to perform awake surgery to preserve quality of life/return to work of adult patients who undergo resection for a supratentorial low-grade glioma (LGG). Based upon the currently available data, the author concludes that in LGG, patients with no or only mild deficits at diagnosis, non-awake surgery can no longer be achieved. Indeed, awake craniotomy with intrasurgical electrical mapping has resulted in an increase of the extent of resection and overall survival in LGG...
November 6, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29104666/lactobacillus-raises-in-vitro-anticancer-effect-of-geniposide-in-hsc-3-human-oral-squamous-cell-carcinoma-cells
#6
Zhou Cheng, Hui Xu, Xiaoping Wang, Zuoye Liu
The present study determined the ability of the Lactobacillus rhamnosus GG strain (LGG) to enhance the anticancer effects of geniposide on HSC-3 human oral squamous carcinoma cells. LGG (1.0×10(3) CFU/ml) on its own had no impact on human oral keratinocytes and HSC-3 cancer cells. Geniposide (25 or 50 µg/ml) had no impact on human oral keratinocytes, but exerted growth inhibitory effects on HSC-3 cancer cells, which were increased in the presence of LGG. Flow cytometric analysis and a nuclear staining assay with DAPI revealed that HSC-3 cancer cells treated with LGG-geniposide (1...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103703/anti-inflammatory-capacity-of-lactobacillus-rhamnosus-gg-in-monophasic-variant-salmonella-infected-piglets-is-correlated-with-impeding-nlrp6-mediated-host-inflammatory-responses
#7
Jiao Yu, Yao-Hong Zhu, Gui-Yan Yang, Wei Zhang, Dong Zhou, Jin-Hui Su, Jiu-Feng Wang
In this study, we investigated the effect of Lactobacillus rhamnosus GG strain (LGG) in ameliorating enteritis in newly weaned pigs following challenge with a monophasic variant of Salmonella enterica serovar Typhimurium (serotyped as 4,[5],12:i:-), which has been linked to disease in humans and livestocks over the past 10 years. In weaned pigs, S. enterica serovar 4,[5],12:i:- induced the mRNA expression of toll like receptor (TLR) 5 and TLR4, while increasing interleukin (IL)-8 and IL-6 mRNA expression in the jejunum...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29101863/contemporary-use-of-intraoperative-imaging-in-glioma-surgery-a-survey-among-eans-members
#8
Jan Coburger, Arya Nabavi, Ralph König, Christian Rainer Wirtz, Andrej Pala
OBJECTIVES: In glioma surgery, intraoperative imaging is regarded highly valuable to improve extent of resection. Current distribution of intraoperative imaging techniques is largely unknown. Further, controversy exists which method might be most beneficial. PATIENTS AND METHODS: We performed a web-based survey among members of the European Association of Neurological Surgeons(EANS) from April to May 2017. Our questionnaire included intraoperative MRI(iMRI), 5-aminolevulinic acid(5-ALA), intraoperative ultrasound(iUS),Na-Fluorescein and intraoperative CT(iCT)...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29100403/lactobacillus-reuteri-zj617-maintains-intestinal-integrity-via-regulating-tight-junction-autophagy-and-apoptosis-in-mice-challenged-with-lipopolysaccharide
#9
Yanjun Cui, Li Liu, Xiaoxiao Dou, Chong Wang, Wenming Zhang, Kan Gao, Jianxin Liu, Haifeng Wang
Live probiotics are effective in reducing gut permeability and inflammation. We have previously reported that Lactobacillus reuteri ZJ617 (ZJ617) with high adhesive and Lactobacillus rhamnosus GG (LGG) can ameliorate intestine inflammation induced by lipopolysaccharide (LPS). The present study was aimed at elucidating the roles of ZJ617 and LGG in alleviating the LPS-induced barrier dysfunction of ileum in mice. Six C57BL/6 mice per group were orally inoculated with ZJ617 or LGG for one week (1× 10(8) CFU/mouse) and intraperitoneally injected with LPS (10 mg/kg body weight) for 24 h...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098889/cost-effectiveness-of-using-an-extensively-hydrolysed-casein-formula-containing-lactobacillus-rhamnosus-gg-in-managing-infants-with-cow-s-milk-allergy-in-the-us
#10
Julian F Guest, Roger H Kobayashi, Vinay Mehta, Gary Neidich
OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolysed casein formula containing the probiotic Lactobacillus rhamnosus GG, (eHCF+LGG; Nutramigen LGG) compared with eHCF alone, and amino acid formulae (AAF) in treating cow's milk allergy (CMA) in the US, from the perspective of third-party insurers and from parents. METHODS: A decision model was used to estimate the probability of cow's milk allergic infants developing tolerance to cow's milk by 18 months...
November 3, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29098732/differentiating-the-histologic-grades-of-gliomas-preoperatively-using-amide-proton-transfer-weighted-aptw-and-intravoxel-incoherent-motion-mri
#11
Tianyu Zou, Hao Yu, Chunxiu Jiang, Xianlong Wang, Shanshan Jiang, Qihong Rui, Yingjie Mei, Jinyuan Zhou, Zhibo Wen
The purpose of this work was to investigate the diagnostic performance of amide proton transfer-weighted (APTW) and intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in the preoperative grading of gliomas. Fifty-one patients with suspected gliomas were recruited and underwent a preoperative MRI examination that included APTW and IVIM sequences. All cases were confirmed by postsurgical histopathology. APTW signal intensity, true diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*) were applied to assess the solid tumor component and contralateral normal-appearing white matter...
November 3, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29077933/genomic-analysis-of-the-origins-and-evolution-of-multicentric-diffuse-lower-grade-gliomas
#12
Josie Hayes, Yao Yu, Llewellyn E Jalbert, Tali Mazor, Lindsey E Jones, Matthew D Wood, Kyle M Walsh, Henrik Bengtsson, Chibo Hong, Stefan Oberndorfer, Thomas Roetzer, Ivan V Smirnov, Jennifer L Clarke, Manish K Aghi, Susan M Chang, Sarah J Nelson, Adelheid Woehrer, Joanna J Phillips, David A Solomon, Joseph F Costello
Background: Rare multicentric lower-grade gliomas (LGG) represent a unique opportunity to study the heterogeneity between distinct tumor foci in a single patient, and to infer their origins and parallel patterns of evolution. Methods: In this study, we integrate clinical features, histology and immunohistochemistry for 4 patients with multicentric LGG, arising both synchronously and metachronously. For 3 patients we analyze the phylogeny of the lesions using exome sequencing, including one case with a total of 8 samples from the two lesions...
October 25, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29060549/classification-of-low-grade-and-high-grade-glioma-using-multi-modal-image-radiomics-features
#13
Hwan-Ho Cho, Hyunjin Park
Gliomas are primary brain tumors arising from glial cells. Gliomas can be classified into different histopathologic grades according to World Health Oraganization (WHO) grading system which represents malignancy. In this paper, we present a method to predict the grades of Gliomas using Radiomics imaging features. MICCAI Brain Tumor Segmentation Challenge (BRATs 2015) training data, its segmentation ground truth and the ground truth labels were used for this work. 45 radiomics features based on histogram, shape and gray-level co-occurrence matrix (GLCM) were extracted from each FLAIR, T1, T1-Contrast, T2 image to quantify the property of Gliomas...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29049847/neurofibromatosis-type-1-and-optic-pathway-glioma-molecular-interplay-and-therapeutic-insights
#14
REVIEW
Soumen Khatua, David H Gutmann, Roger J Packer
Children with neurofibromatosis type 1 (NF1) are predisposed to develop central nervous system neoplasms, the most common of which are low-grade gliomas (LGGs). The absence of human NF1 associated LGG-derived cell lines, coupled with an inability to generate patient-derived xenograft models, represents barriers to profile molecularly targeted therapies for these tumors. Thus, genetically engineered mouse models have been identified to evaluate the interplay between Nf1-deficient tumor cells and nonneoplastic stromal cells to evaluate potential therapies for these neoplasms...
October 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29043005/impact-of-supplementation-with-a-food-derived-microbial-community-on-obesity-associated-inflammation-and-gut-microbiota-composition
#15
Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami, Giuditta Perozzi
BACKGROUND: Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplementation was suggested to be capable of counteracting obesity-associated immune and microbial alterations, based on its proven immunomodulatory activity and positive effect on gut microbial balance. Traditional fermented foods represent a natural source of live microbes, including environmental strains with probiotic features, which could transiently colonise the gut...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/29041974/postoperative-functional-status-in-patients-with-supratentorial-superficial-low-grade-glioma
#16
Ji Zhang, Yin Sheng Chen, You-Ping Li, Zheng-Quan Zhu, Jian-Min Liu, Cheng-Cheng Guo, Qun-Ying Yang, Xiao-Li Wang, Ying-Hua Rao, Qing Mao, Wen-Yan Li, Lu Ma, Yun Qiang Yang, Shi-Yin Xiao
BACKGROUND: We investigated the functional status of adult supratentorial superficial low-grade glioma (ASS-LGG) after surgery and analyzed its relevant factors to guide the therapeutic strategy and improve the life quality of these patients. METHODS: Clinical materials from January 2008 to December 2010 in 104 adults with ASS-LGG were analyzed retrospectively. The follow-up period ranged from 6 months to 1.5 years. The logistic regression was used to evaluate the preoperative and postoperative variation of functional status in patients to disclose the relevant factors affecting postoperative functional status, such as age, gender, the duration of symptom, size and location of the tumor, hemisphere, resection degree, and tumor pathologic grade and preoperative Karnofsky performance status (Pre-KPS)...
October 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29040023/dramatic-clinical-and-radiographic-response-to-braf-inhibition-in-a-patient-with-progressive-disseminated-optic-pathway-glioma-refractory-to-mek-inhibition
#17
Abhishek Bavle, Jeremy Jones, Frank Y Lin, Amy Malphrus, Adekunle Adesina, Jack Su
While clinical and radiographic responses to agents targeting the mitogen-activated protein kinases (MAPK) pathway have been repor-ted in pediatric low-grade gliomas (LGG), early phase trials indicate refractoriness to these medications in some of these patients. We report a patient with disseminated LGG with the BRAFV600E mutation, which was refractory to selumetinib, a MEK inhibitor, but subsequently showed immediate clinical and radiographic response to dabrafenib, a BRAF inhibitor, with sustained effect for 9 months prior to clinical progression...
October 17, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29038557/anti-infective-effect-of-adhesive-probiotic-lactobacillus-in-fish-is-correlated-with-their-spatial-distribution-in-the-intestinal-tissue
#18
Suxu He, Chao Ran, Chubin Qin, Shuning Li, Hongling Zhang, Willem M de Vos, Einar Ringø, Zhigang Zhou
In this study, we tested the distribution of 49 Lactobacillus strains in the mucus and mucosa of the intestine tissue of zebrafish. We observed a progressive change in the spatial distribution of Lactobacillus strains, and suggested a division of the strains into three classes: mucus type (>70% in mucus), mucosa type (>70% in mucosa) and hybrid type (others). The hybrid type strains were more efficient in protection of zebrafish against Aeromonas hydrophila infection. Three strains representing different distribution types (JCM1149, CGMCC1...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037775/neuroendocrine-late-effects-after-tailored-photon-radiotherapy-for-children-with-low-grade-gliomas-long-term-correlation-with-tumour-and-treatment-parameters
#19
Deborah Aloi, Liliana Belgioia, Salvina Barra, Flavio Giannelli, Francesca Cavagnetto, Fabio Gallo, Claudia Milanaccio, MariaLuisa Garrè, Sonia Di Profio, Natascia Di Iorgi, Renzo Corvò
PURPOSE: To evaluate neuroendocrine late effects in paediatric patients with low grade glioma (LGG) who underwent radiotherapy. METHODS AND MATERIAL: We performed a retrospective evaluation of 40 children with LGG treated from July 2002 to January 2015 with external radiotherapy. Tumour locations were cerebral hemisphere (n=2); posterior fossa (n=15); hypothalamic-pituitary axis (HPA, n=15); spine (n=5). Three patients presented a diffuse disease. We looked for a correlation between endocrine toxicity and tumour and treatment parameters...
October 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29032650/immunomodulatory-potential-of-weissella-cibaria-in-aged-c57bl-6j-mice
#20
Ho-Eun Park, Kyung-Won Kang, Bum-Seok Kim, Sang-Myeong Lee, Wan-Kyu Lee
Aging is associated with distinct changes in immune cells and a decline in immune function, leading to increased susceptibility to infection and reduced responses to vaccination. Certain strains of lactic acid bacteria exert beneficial effects on the immune system. Previously, we reported that Weissella cibaria JW15 isolated from kimchi possesses immune stimulatory activity in vitro. In the present study, we further investigated whether oral administration of JW15 improves immune function in aged mice. Eighteen-month-old female mice were administered JW15 daily at low (JW15-L; 1×10⁸ CFU/mouse) or high dosage (JW15-H; 1×10⁸ CFU/mouse), or with Lactobacillus rhamnosus GG using oral gavage...
October 14, 2017: Journal of Microbiology and Biotechnology
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