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Super utilizer

A Belén Marco, Denis Gindre, Konstantinos Iliopoulos, Santiago Franco, Raquel Andreu, David Canevet, Marc Sallé
The present work takes advantage of the self-assembly process occurring along organogelation, to organize Second Harmonic Generation (SHG) active chromophores. To do so, three push-pull chromophores endowed with a dodecyl urea chain were synthesized and characterized. Their organogelating properties were studied in a wide range of solvents. Despite similar architectures, these derivatives exhibit very different gelling properties, from supergelation to the absence of gelling ability. The utilization of the Hansen solubility parameters allows for observing clear relationships between the gelled solvents and critical gelation concentrations...
March 21, 2018: Organic & Biomolecular Chemistry
Longcan Mei, Yanping Zhou, Lizhe Zhu, Changlin Liu, Zhuo Wu, Fangkui Wang, Gefei Hao, Di Yu, Hong Yuan, Yanfang Cui
A superkine variant of interleukin-2 with six site mutations away from the binding interface developed from the yeast display technique has been previously characterized as undergoing a distal structure alteration which is responsible for its super-potency and provides an elegant case study with which to get insight about how to utilize allosteric effect to achieve desirable protein functions. By examining the dynamic network and the allosteric pathways related to those mutated residues using various computational approaches, we found that nanosecond time scale all-atom molecular dynamics simulations can identify the dynamic network as efficient as an ensemble algorithm...
March 20, 2018: International Journal of Molecular Sciences
Karthikeyan E Ponnusamy, Edward M Vasarhelyi, Lyndsay Somerville, Richard W McCalden, Jacquelyn D Marsh
BACKGROUND: We estimated the cost-effectiveness of performing total knee arthroplasty (TKA) vs nonoperative management (NM) among 6 body mass index (BMI) cohorts. METHODS: A Markov model was used to compare the cost-utility of TKA and NM in 6 BMI groups (nonobese [BMI 18.5-24.9], overweight [25-29.9], obese [30-34.9], severely obese [35-39.9], morbidly obese [40-49.9], and super-obese [50+] patients) over a 15-year period. Model parameters for transition probability (ie, revision, re-revision, death), utility, and costs were estimated from the literature...
February 14, 2018: Journal of Arthroplasty
Shiguang Wang, Bingtian Ma, Qiang Gao, Guojing Jiang, Lei Zhou, Bin Tu, Peng Qin, Xueqin Tan, Peixiong Liu, Yunhai Kang, Yuping Wang, Weilan Chen, Chengzhi Liang, Shigui Li
Shuhui498 (R498) is an elite parent of heavy panicle hybrid rice by pyramiding the rare gn1a and null gs3 alleles. This finding reveals the genetic basis and great potential application in future breeding of R498. The heavy panicle trait, defined as 5 g or more of grain weight per panicle, is one of the target traits in super-high-yield rice breeding programs. The use of heavy panicle-type hybrid rice has been shown to be a successful strategy for super-high-yield breeding programs, particularly under the environmental conditions of high humidity and deficient solar radiation in southwestern China...
March 15, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Danuta Gutowska-Owsiak, Jorge Bernardino de La Serna, Marco Fritzsche, Aishath Naeem, Ewa I Podobas, Michael Leeming, Huw Colin-York, Ryan O'Shaughnessy, Christian Eggeling, Graham S Ogg
Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier. Cornification is dynamically controlled by the protein filaggrin, rapidly released from keratohyalin granules (KHGs). However, the mechanisms of cornification largely remain elusive, partly due to limitations of the observation techniques employed to study filaggrin organization in keratinocytes. Moreover, while the abundance of keratins within KHGs has been well described, it is not clear whether actin also contributes to their formation or fate...
March 15, 2018: Cell Death & Disease
Samuel B Penwell, Lukas Whaley-Mayda, Andrei Tokmakoff
We present the design and characterization of a tunable mid-IR optical parametric amplifier (OPA) with a 1 MHz 1033 nm fiber laser pump source. The OPA generates >10  nJ/pulse tunable from 3-7.5 μm with 85-165  cm-1 bandwidth and 140-540 fs pulse durations. The design utilizes a single stage of collinear, Type I amplification in lithium gallium sulfide (LGS) seeded by the near-IR portion of a super-continuum (SC) generated in yttrium aluminum garnet (YAG). The resulting mid-IR idler beam is isolated as the output...
March 15, 2018: Optics Letters
Benjamin Gottschalk, Christinae Klec, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F Graier
Mitochondria are multifunctional organelles that essentially contribute to cell signaling by sophisticated mechanisms of communications. Live cell imaging studies showed that mitochondria are dynamic and complex structures that form ramified networks by directed movements, fission, and fusion events. There is emerging evidence that the morphology of mitochondria determines cellular functions and vice versa. Several intracellular signaling pathways and messengers including Ca2+ dynamically influence the architecture of mitochondria...
March 12, 2018: Pflügers Archiv: European Journal of Physiology
Currie Moore, Rabiya Majeed-Ariss, Anuradha Jayanti, Sandip Mitra, Suzanne Skevington, Alison Wearden
OBJECTIVES: Despite home haemodialysis (HHD) being associated with significant health and psychosocial benefits, it remains an under-utilized dialysis modality for people with chronic kidney disease. Self-cannulation, where patients insert their own needles for dialysis, is a key component of HHD. Recent research suggests that the prospect of self-cannulation is a barrier for patients, but there is little research which examines why this is the case. The aim of this study was to explore male HHD patients' experiences and attitudes towards self-cannulation...
March 6, 2018: British Journal of Health Psychology
David Virant, Bjoern Traenkle, Julia Maier, Philipp D Kaiser, Mona Bodenhöfer, Christian Schmees, Ilijana Vojnovic, Borbála Pisak-Lukáts, Ulrike Endesfelder, Ulrich Rothbauer
Dense fluorophore labeling without compromising the biological target is crucial for genuine super-resolution microscopy. Here we introduce a broadly applicable labeling strategy for fixed and living cells utilizing a short peptide tag-specific nanobody (BC2-tag/bivBC2-Nb). BC2-tagging of ectopically introduced or endogenous proteins does not interfere with the examined structures and bivBC2-Nb staining results in a close-grained fluorophore labeling with minimal linkage errors. This allowed us to perform high-quality dSTORM imaging of various targets in mammalian and yeast cells...
March 2, 2018: Nature Communications
Mehran Kianinia, Carlo Bradac, Bernd Sontheimer, Fan Wang, Toan Trong Tran, Minh Nguyen, Sejeong Kim, Zai-Quan Xu, Dayong Jin, Andreas W Schell, Charlene J Lobo, Igor Aharonovich, Milos Toth
Layered van der Waals materials are emerging as compelling two-dimensional platforms for nanophotonics, polaritonics, valleytronics and spintronics, and have the potential to transform applications in sensing, imaging and quantum information processing. Among these, hexagonal boron nitride (hBN) is known to host ultra-bright, room-temperature quantum emitters, whose nature is yet to be fully understood. Here we present a set of measurements that give unique insight into the photophysical properties and level structure of hBN quantum emitters...
February 28, 2018: Nature Communications
Sarah Elizabeth Morrison, Caroline Bruce, Sarah Wilson
This study evaluates and synthesizes qualitative evidence addressing factors affecting a child's decision to disclose an experience of sexual abuse. Childhood sexual abuse is a devastating crime, with long-term negative impacts. Understanding the factors that affect a child's decision to disclose is vital. Disclosure enables access to support and protection, both therapeutically and legally. A systematic review was conducted focusing on factors affecting a child's decision to disclose an experience of sexual abuse...
February 28, 2018: Journal of Child Sexual Abuse
Xinglong Ji, Li Song, Wei He, Kejie Huang, Zhiyuan Yan, Shuai Zhong, Yishu Zhang, Rong Zhao
Selector element with high nonlinearity is an indispensable part in constructing high density, large-scale, 3-D stackable emerging non-volatile memory (NVM) and neuromorphic network. Although significant efforts have been devoted to developing novel thin-film selectors, it remains a great challenge in achieving good switching performance in the selectors to satisfy the stringent electrical criteria of diverse memory elements. In this work, we utilized high-defect-density chalcogenide glass (Ge2Sb2Te5) in conjunction with high mobility Ag element (Ag-GST) to achieve a super nonlinear selective switching...
February 28, 2018: ACS Applied Materials & Interfaces
Jill D Nault Connors, Bonnie L Binkley, J Carolyn Graff, Satya Surbhi, James E Bailey
No abstract text is available yet for this article.
February 21, 2018: Healthcare
Silvia Boffo, Angela Damato, Luigi Alfano, Antonio Giordano
Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and rational combinations. Targeting the cyclin-dependent kinase 9 (CDK9) pathway, which is dysregulated in AML, is an attractive approach. Inhibition of CDK9 leads to downregulation of cell survival genes regulated by super enhancers such as MCL-1, MYC, and cyclin D1. As CDK9 inhibitors are nonselective, predictive biomarkers that may help identify patients most likely to respond to CDK9 inhibitors are now being utilized, with the goal of improving efficacy and safety...
February 23, 2018: Journal of Experimental & Clinical Cancer Research: CR
Ram M Narayanan, Richard K Pooler, Anthony F Martone, Kyle A Gallagher, Kelly D Sherbondy
This paper describes a multichannel super-heterodyne signal analyzer, called the Spectrum Analysis Solution (SAS), which performs multi-purpose spectrum sensing to support spectrally adaptive and cognitive radar applications. The SAS operates from ultrahigh frequency (UHF) to the S-band and features a wideband channel with eight narrowband channels. The wideband channel acts as a monitoring channel that can be used to tune the instantaneous band of the narrowband channels to areas of interest in the spectrum...
February 22, 2018: Sensors
Julie A Campbell, Martin Hensher, Amanda Neil, Alison Venn, Stephen Wilkinson, Andrew J Palmer
BACKGROUND: Long-term publicly waitlisted bariatric surgery patients typically experience debilitating physical/psychosocial obesity-related comorbidities that profoundly affect their quality of life. OBJECTIVES: We sought to measure quality-of-life impacts in a study population of severely obese patients who had multiyear waitlist times and then underwent bariatric surgery. METHODS: Participants were recruited opportunistically following a government-funded initiative to provide bariatric surgery to morbidly obese long-term waitlisted patients...
March 2018: PharmacoEconomics Open
Jeremy Ziring, Spriha Gogia, Remle Newton-Dame, Jesse Singer, Dave A Chokshi
No abstract text is available yet for this article.
February 20, 2018: Journal of General Internal Medicine
Casey M Hay, Joseph L Kelley, Robert P Edwards, Kathleen M Pombier, John T Comerci
Super-utilizers account for many emergency department visits (EDV) and hospitalizations. Among Medicare/Medicaid patients, 5% to 10% account for >50% of spending. Little is known about super-utilization in gynecologic oncology. Charts of 64 gynecologic oncology patients with ≥3 EDV and/or admissions over 12 months were reviewed retrospectively. Cancer type distribution was 47% ovarian, 23% cervical, 23% endometrial, and 6% vulvar. Treatment at index visit was 61% chemotherapy, 16% no treatment, 8% recent surgery, and 6% radiation...
February 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
Michael P Thompson, Pradeep S B Podila, Chip Clay, Joy Sharp, Sandra Bailey-DeLeeuw, Armika J Berkley, Bobby G Baker, Teresa M Waters
OBJECTIVES: Super-utilizers place a significant burden on the healthcare system. Blending the roles of patient navigators and community health workers may address the clinical and social needs of these patients. This study evaluated the effectiveness of community navigators in reducing hospital utilization and costs among super-utilizers from a low-income area in Memphis, Tennessee. STUDY DESIGN: Controlled pre-post (difference-in-differences [DID]) design using Methodist Le Bonheur Healthcare electronic health records from 2013 to 2016...
February 2018: American Journal of Managed Care
Wei Wang, Jiqiu Qi, Yanwei Sui, Yezeng He, Qingkun Meng, Fuxiang Wei, Yunxue Jin
A facile method was utilized to convert a common biomass of walnut shells into activated porous carbon by carbonization and activation with nitricacid treatment. The obtained activated carbon (WSs-2) exhibited excellent electrochemical performance with high specific capacitance of 137 F · g-1 at 1 A · g-1 and super cycling performance of 96% capacitance retention at 5 A · g-1 after 5000 cycles. In addition, NiCo2O4 nanoneedle arrays with good electrochemical properties were successfully prepared by a simple hydrothermal method...
August 1, 2018: Journal of Nanoscience and Nanotechnology
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