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Super utilizer

Jing-Min Liu, Yao-Yao Liu, Dong-Dong Zhang, Guozhen Fang, Shuo Wang
The rise of multimodal nanoprobes has promoted the development of new methods to explore multiple molecular targets simultaneously, or to combine various bioimaging tools in one assay to more clearly delineate localization and expression of bio-markers. Persistent luminescence nanophosphors (PLNPs) have been qualified as the promising contrast agent for in vivo imaging. The easy surface modification and proper nanostructure design strategy would favor the fabrication of PLNPs based multi-functional nanoprobes for biological application...
October 19, 2016: ACS Applied Materials & Interfaces
Lena-Marie Kortland, Anne Alfter, Oliver Bähr, Barbara Carl, Richard Dodel, Thomas M Freiman, Kristina Hubert, Kolja Jahnke, Susanne Knake, Felix von Podewils, Jens-Peter Reese, Uwe Runge, Christian Senft, Helmuth Steinmetz, Felix Rosenow, Adam Strzelczyk
OBJECTIVE: To provide first data on inpatient costs and cost-driving factors due to nonrefractory status epilepticus (NSE), refractory status epilepticus (RSE), and super-refractory status epilepticus (SRSE). METHODS: In 2013 and 2014, all adult patients treated due to status epilepticus (SE) at the university hospitals in Frankfurt, Greifswald, and Marburg were analyzed for healthcare utilization. RESULTS: We evaluated 341 admissions in 316 patients (65...
October 18, 2016: Epilepsia
Lukas C Buelens, Vladimir V Galvita, Hilde Poelman, Christophe Detavernier, Guy B Marin
Efficient CO2 transformation from a waste product to carbon source for chemicals and fuels will require reaction conditions that effect its reduction. We develop a "super-dry" CH4 reforming reaction for enhanced CO production from CH4 and CO2 We used Ni/MgAl2O4 as a CH4 reforming catalyst, Fe2O3/MgAl2O4 as a solid oxygen carrier, and CaO/Al2O3 as a CO2 sorbent. The isothermal coupling of these three different processes resulted in higher CO production compared with conventional dry reforming by avoiding back reactions with water...
October 13, 2016: Science
Mako Kamiya
 Fluorescence imaging is one of the most powerful techniques currently available for continuous observation of intracellular processes in living cells and tissues, and so it would be useful to have a large toolset of fluorescence probes suitable for visualizing bioactive molecules or biological phenomena. However, design strategies for small molecule-based fluorescence probes have been limited. Therefore, we are interested in establishing novel rational design strategies for developing functional fluorescence probes...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Sebastián A Díaz, Florencia Gillanders, Kimihiro Susumo, Eunkeu Oh, Igor L Medintz, Thomas M Jovin
Photoswitchable probes are of great utility in fluorescence microscopy, permitting numerous determinations, including molecular localization for super-resolution, based on their modifiable emission intensity and spectra. We have coated a blue (425 nm) emitting quantum dot (QD) with a diheteroarylethene photochrome (PCf), the closed form isomer of which has absorption and emission maxima at 440 and 520-530 nm, respectively, and thus functions as a fluorescent acceptor for the QD donor in Förster resonance energy transfer (FRET)...
October 9, 2016: Chemistry: a European Journal
Satya Surbhi, Kiraat D Munshi, Paula C Bell, James E Bailey
OBJECTIVES: First, to investigate the prevalence and types of drug therapy problems and medication discrepancies among super-utilizers, and associated patient characteristics. Second, to examine the outcomes of pharmacist recommendations and estimated cost avoidance through care transitions support focused on medication management. DESIGN: Retrospective analysis of the pharmacist-led interventions as part of the SafeMed Program. SETTING: A large nonprofit health care system serving the major medically underserved areas in Memphis, Tennessee...
October 6, 2016: Journal of the American Pharmacists Association: JAPhA
Jason Yi, Asit Manna, Valarie A Barr, Jennifer Hong, Keir C Neuman, Lawrence E Samelson
Investigation of heterogeneous cellular structures using single molecule localization microscopy has been limited by poorly defined localization accuracy and inadequate multiplexing capacity. Utilizing fluorescent nano-diamonds as fiducial markers, we define and achieve localization precision required for single molecule accuracy in dSTORM images. Coupled with this advance, our new multiplexing strategy, madSTORM allows accurate targeting of multiple molecules using sequential binding and elution of fluorescent antibodies...
October 5, 2016: Molecular Biology of the Cell
Jing Jin, Shoujun Zhu, Yubin Song, Hongyue Zhao, Zhen Zhang, Yue Guo, Junbo Li, Wei Song, Bai Yang, Bing Zhao
Carbon dots (CDs) have attracted extensive interest owing to their unparalleled physical and chemical characteristics. CDs based nanocomposites have also drawn increasing attention because the combination of different characteristics could offer additional brilliant properties (such as photocatalysis and Raman scattering). In this work, we developed a fast, facile, and controllable method for fabricating core-shell Ag@CDs nanoparticles (NPs) based on the ability of CDs to directly reduce Ag(+) to Ag NPs without an external photoirradiation process or additional reductants...
October 10, 2016: ACS Applied Materials & Interfaces
Yelong Zheng, Hongyu Lu, Wei Yin, Dashuai Tao, Lichun Shi, Yu Tian
Forces acted on legs of water-walking arthropods with weights in dynes are of great interest for entomologist, physicists, and engineers. While their floating mechanism has been recognized, the in vivo leg forces stationary have not yet been simultaneously achieved. In this study, their elegant bright-edged leg shadows are used to make the tiny forces visible and measurable based on the updated Archimedes' principle. The force was approximately proportional to the shadow area with a resolution from nanonewton to piconewton/pixel...
October 7, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Hong Yao, Zhangqi Shen, Yang Wang, Fengru Deng, Dejun Liu, Gaowa Naren, Lei Dai, Chih-Chia Su, Bing Wang, Shaolin Wang, Congming Wu, Edward W Yu, Qijing Zhang, Jianzhong Shen
UNLABELLED: Bacterial antibiotic efflux pumps are key players in antibiotic resistance. Although their role in conferring multidrug resistance is well documented, the emergence of "super" efflux pump variants that enhance bacterial resistance to multiple drugs has not been reported. Here, we describe the emergence of a resistance-enhancing variant (named RE-CmeABC) of the predominant efflux pump CmeABC in Campylobacter, a major zoonotic pathogen whose resistance to antibiotics is considered a serious antibiotic resistance threat in the United States...
2016: MBio
Ruxue Wei, Xueming Zhao, Haisheng Hao, Weihua Du, Huabin Zhu
The rabbit is considered an important model animal from which to obtain embryonic stem cells because of the utility of this animal in physiology and reproductive research. Here, we derived rabbit ES-like (rES-like) cells from blastocysts of superovulated Japanese white rabbits using culture medium containing 10(-7)  M melatonin, 10 ng/mL basic fibroblast growth factor, and 1,000 IU/mL human leukemia inhibitory factor. This concentration of melatonin had the most significant positive effects on the proliferation inner cell mass-derived cells (improving rates from 19...
September 20, 2016: Molecular Reproduction and Development
Jonathan Jeffet, Asaf Kobo, Tianxiang Su, Assaf Grunwald, Ori Green, Adam N Nilsson, Eli Eisenberg, Tobias Ambjornsson, Fredrik Westerlund, Elmar Weinhold, Doron Shabat, Prashant K Purohit, Yuval Ebenstein
Optical genome mapping in nanochannels is a powerful genetic analysis method, complementary to DNA sequencing. The method is based on detecting a pattern of fluorescent labels attached along individual DNA molecules. When such molecules are extended in nanochannels, the labels create a fluorescent genetic barcode that is used for mapping the DNA molecule to its genomic locus and identifying large-scale variation from the genome reference. Mapping resolution is currently limited by two main factors; the optical diffraction limit and the thermal fluctuations of DNA molecules suspended in the nanochannels...
September 19, 2016: ACS Nano
Elizabeth G Crichton, Clara Malo, Budhan S Pukazhenthi, Peter Nagy, Julian A Skidmore
Cholesterol (cholesterol-loaded cyclodextrins: CLC) treatment of dromedary camel sperm prior to freezing enhances cryosurvival. The present study first validated the efficacy of a heterologous zona-free goat oocyte assay (n=115 oocytes) to evaluate camel sperm function in vitro (Experiment 1: n=6 bulls), then examined the effects of CLC treatment (1.5mg/mL CLC; CLC+) versus no treatment (0 CLC) of fresh (Experiment 2: n=4 bulls) and frozen-thawed (Experiment 3: n=5 bulls) camel sperm to penetrate, de-condense and form pro-nuclei in in vitro-matured goat oocytes...
August 31, 2016: Animal Reproduction Science
Qiangbing Guo, Yunhua Yao, Zhi-Chao Luo, Zhipeng Qin, Guoqiang Xie, Meng Liu, Jia Kang, Shian Zhang, Gang Bi, Xiaofeng Liu, Jianrong Qiu
Field effect relies on the nonlinear current-voltage relation in semiconductors; analogously, materials that respond nonlinearly to optical field can be utilized for optical modulation. For instance, nonlinear optical materials bearing saturable absorption (SA) features an on-off switching behavior at the critical pumping power, thus enabling ultrafast laser pulse generation with high peak power. SA have been observed in diverse materials preferably in their nanoscale form, including both gaped semiconductor nanostructures and gapless materials like graphene; while the presence of optical bandgap and small carrier density have limited the active spectral range and intensity...
September 13, 2016: ACS Nano
Brian C Werner, Matthew D Higgins, Hakan C Pehlivan, Joshua T Carothers, James A Browne
BACKGROUND: Recent studies have reported higher postoperative complication rates in obese and morbidly obese patients undergoing total hip arthroplasty (THA). Less data are available regarding super-obese (body mass index [BMI] >50 kg/m(2)) patients. This study aims to quantify the risk of complications after THA in super-obese patients on a national scale and to put these risks in context by comparing them to patients of other BMI classes as well as those undergoing revision THA. METHODS: Utilizing a national insurance database, complication rates after THA in super-obese patients (n = 3244) were compared to nonobese, obese, and morbidly obese patients undergoing primary THA and all patients undergoing revision THA...
August 9, 2016: Journal of Arthroplasty
Qiang Ren, Yi Wang, Kui-Jie Wei
PURPOSE: To evaluate the clinical effect of 3 polishing methods on resin composite restoration in filling wedge-shaped defect. METHODS: One hundred and fifty patients with wedge-shaped defects were randomly divided into 3 groups. After being filled with Nano composite resin(FILTEK Z350,3M), restorations in group 1 were polished with Sof-lex discs system, restorations in group 2 were polished with Super-snap system and group 3 with diamond bur and rubber cup. Restorations in each group were reexamined and assessed utilizing standards of USPH&Ryge after 0...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
P Kokeny, Y C N Cheng, S Liu, H Xie, Q Jiang
Cells labeled by super paramagnetic iron-oxide (SPIO) nanoparticles are more easily seen in gradient echo MR images, but it has not been shown that the amount of nanoparticles or the number of cells can be directly quantified from MR images. This work utilizes a previously developed and improved Complex Image Summation around a Spherical or Cylindrical Object (CISSCO) method to quantify the magnetic moments of several clusters of SPIO nanoparticle labeled cells from archived rat brain images. With the knowledge of mass magnetization of the cell labeling agent and cell iron uptake, the number of cells in each nanoparticle cluster can be determined...
September 1, 2016: Magnetic Resonance Imaging
Alireza Asiaee, Kenneth M Benjamin
For several decades, heterogeneous catalytic processes have been improved through utilizing supercritical fluids (SCFs) as solvents. While numerous experimental studies have been established across a range of chemistries, such as oxidation, pyrolysis, amination, and Fischer-Tropsch synthesis, still there is little fundamental, molecular-level information regarding the role of the SCF on elementary heterogeneous catalytic steps. In this study, the influence of hexane solvent on the adsorption of carbon monoxide on Co(0001), as the first step in the reaction mechanism of many processes involving syngas conversion, is probed...
August 28, 2016: Journal of Chemical Physics
Farid Ullah Khan
For wireless sensor node (WSN) applications, this paper presents the harvesting of energy from the stray electromagnetic field around an electrical power line. Inductive and capacitive types of electrodynamic energy harvesters are developed and reported. For the produced energy harvesters, solid core and split-core designs are adopted. The inductive energy harvester comprises a copper wound coil which is produced on a mild steel core. However, the capacitive prototypes comprise parallel, annular discs separated by Teflon spacers...
2016: TheScientificWorldJournal
Jorge Garcia-Sucerquia
A comparison of the performance of color digital lensless holographic microscopy (CDLHM) as utilized for illumination of RGB lasers or a super-bright white-light LED with a set of spectral filters is presented. As the use of lasers in CDLHM conceals the possibility of having a compact, lightweight, portable, and low cost microscope, and additionally the limited available laser radiation wavelengths limit a real multispectral imaging microscope, here we present the use of super-bright white-light LED and spectral filters for illuminating the sample...
August 20, 2016: Applied Optics
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