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https://www.readbyqxmd.com/read/28716441/unraveling-the-meaning-of-chemical-shifts-in-protein-nmr
#1
REVIEW
Mark V Berjanskii, David S Wishart
Chemical shifts are among the most informative parameters in protein NMR. They provide wealth of information about protein secondary and tertiary structure, protein flexibility, and protein-ligand binding. In this report, we review the progress in interpreting and utilizing protein chemical shifts that has occurred over the past 25years, with a particular focus on the large body of work arising from our group and other Canadian NMR laboratories. More specifically, this review focuses on describing, assessing, and providing some historical context for various chemical shift-based methods to: (1) determine protein secondary and super-secondary structure; (2) derive protein torsion angles; (3) assess protein flexibility; (4) predict residue accessible surface area; (5) refine 3D protein structures; (6) determine 3D protein structures and (7) characterize intrinsically disordered proteins...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28710413/quantifying-retail-agglomeration-using-diverse-spatial-data
#2
Duccio Piovani, Vassilis Zachariadis, Michael Batty
Newly available data on the spatial distribution of retail activities in cities makes it possible to build models formalized at the level of the single retailer. Current models tackle consumer location choices at an aggregate level and the opportunity new data offers for modeling at the retail unit level lacks an appropriate theoretical framework. The model we present here helps to address these issues. Based on random utility theory, we have built it around the idea of quantifying the role of floor-space and agglomeration in retail location choice...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698960/genome-wide-qtl-analysis-identified-significant-associations-between-hypoxia-tolerance-and-mutations-in-the-gpr132-and-abcg4-genes-in-nile-tilapia
#3
Hong Lian Li, Xiao Hui Gu, Bi Jun Li, Chao Hao Chen, Hao Ran Lin, Jun Hong Xia
Exposure to hypoxia induces both acute and chronic stress responses, which plays an important role in health of cultured organisms including growth, reproduction, immunity, and other energy demanding activities. Application of advanced genomic technologies allows rapid identification of hypoxia trait-associated genes and precise selection of superior brood stocks with high tolerance in tilapia. By applying QTL-seq and double-digest restriction-site associated DNA sequencing (ddRAD-seq) techniques, we identified four genome-wide significant quantitative trait loci (QTLs) for hypoxia tolerance and many suggestive QTLs in Nile tilapia...
July 11, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28691799/solid-contact-ph-sensor-without-co2-interference-with-a-super-hydrophobic-pedot-c14-as-solid-contact-the-ultimate-water-layer-test
#4
Marcin Guzinski, Jennifer Marie Jarvis, Paul D'Orazio, Anahita Izadyar, Bradford D Pendley, Erno Lindner
The aim of this study was to find a conducting polymer-based solid contact (SC) for ion-selective electrodes (ISEs) that could appeal to become the ultimate, generally applicable SC, which in combination with all kinds of ion-selective membranes (ISMs) would match the performance characteristics of conventional ISEs. We present data collected with electrodes utilizing PEDOT-C14, a highly hydrophobic derivative of poly(3,4-ethylenedioxythiophene), PEDOT, as SC and compare its performance characteristics with PEDOT-based SC ISEs...
July 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28671662/long-time-lapse-nanoscopy-with-spontaneously-blinking-membrane-probes
#5
Hideo Takakura, Yongdeng Zhang, Roman S Erdmann, Alexander D Thompson, Yu Lin, Brian McNellis, Felix Rivera-Molina, Shin-Nosuke Uno, Mako Kamiya, Yasuteru Urano, James E Rothman, Joerg Bewersdorf, Alanna Schepartz, Derek Toomre
Imaging cellular structures and organelles in living cells by long time-lapse super-resolution microscopy is challenging, as it requires dense labeling, bright and highly photostable dyes, and non-toxic conditions. We introduce a set of high-density, environment-sensitive (HIDE) membrane probes, based on the membrane-permeable silicon-rhodamine dye HMSiR, that assemble in situ and enable long time-lapse, live-cell nanoscopy of discrete cellular structures and organelles with high spatiotemporal resolution. HIDE-enabled nanoscopy movies span tens of minutes, whereas movies obtained with labeled proteins span tens of seconds...
July 3, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28669852/dynamin-regulates-the-fusion-pore-of-endo-and-exocytotic-vesicles-as-revealed-by-membrane-capacitance-measurements
#6
Eva Lasič, Matjaž Stenovec, Marko Kreft, Phillip J Robinson, Robert Zorec
BACKGROUND: Dynamin is a multidomain GTPase exhibiting mechanochemical and catalytic properties involved in vesicle scission from the plasmalemma during endocytosis. New evidence indicates that dynamin is also involved in exocytotic release of catecholamines, suggesting the existence of a dynamin-regulated structure that couples endo- to exocytosis. METHODS: Thus we here employed high-resolution cell-attached capacitance measurements and super-resolution structured illumination microscopy to directly examine single vesicle interactions with the plasmalemma in cultured rat astrocytes treated with distinct pharmacological modulators of dynamin activity...
June 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28657819/cares-a-community-wide-collaboration-identifies-super-utilizers-and-reduces-their-9-1-1-call-emergency-department-and-hospital-visit-rates
#7
E Stein Bronsky, Constance McGraw, Robin Johnson, Kristin Giordano, Alessandro Orlando, David Bar-Or
BACKGROUND: A subset of individuals who inefficiently and frequently use emergency department (ED) services are called "super-utilizers." Our healthcare system is fragmented and complex, making it difficult for providers to identify super-utilizers and address their wide range of health issues. OBJECTIVE: The objective of our study was to evaluate a novel community-wide collaboration program called CARES (Community Assistance Referral and Education Services) designed to identify super-utilizers through local partnering organizations...
June 28, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28651183/investigating-the-effect-of-different-transducer-stiffness-values-on-the-contactin-complex-detachment-by-steered-molecular-dynamics
#8
Parnian Kianfar, Nabiollah Abolfathi, Navid Zarif Karimi
This study investigated the adhesion behavior of Contactin4 (CNTN4), a member of Immunoglobulin Super Family (Ig-SF) of cell adhesion molecules. Contactin4 plays a crucial role in the formation, maintenance, and plasticity of neuronal networks. Contactin in its complex configuration with protein tyrosine phosphatase gamma (PTPRG) was selected for simulation. By utilizing Steered Molecular Dynamics (SMD), the uniaxial force was applied to induce unbinding of the complex, and the force-induced detachment of complex components was probed...
June 2, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28643362/-super-reducing-photocatalysis-consecutive-energy-and-electron-transfers-with-polycyclic-aromatic-hydrocarbons
#9
Malte Brasholz
Donation welcome: Recent developments in visible-light photocatalysis allow the utilization of increasingly negative reduction potentials. Successive energy and electron transfer with polycyclic aromatic hydrocarbons enables the catalytic formation of strongly reducing arene radical anions, classical stoichiometric reagents for one-electron reduction in organic synthesis.
June 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28617338/indoor-autonomous-control-of-a-two-wheeled-inverted-pendulum-vehicle-using-ultra-wide-band-technology
#10
Dunzhu Xia, Yanhong Yao, Limei Cheng
In this paper, we aimed to achieve the indoor tracking control of a two-wheeled inverted pendulum (TWIP) vehicle. The attitude data are acquired from a low cost micro inertial measurement unit (IMU), and the ultra-wideband (UWB) technology is utilized to obtain an accurate estimation of the TWIP's position. We propose a dual-loop control method to realize the simultaneous balance and trajectory tracking control for the TWIP vehicle. A robust adaptive second-order sliding mode control (2-RASMC) method based on an improved super-twisting (STW) algorithm is investigated to obtain the control laws, followed by several simulations to verify its robustness...
June 15, 2017: Sensors
https://www.readbyqxmd.com/read/28607348/construction-of-sno2-graphene-composite-with-half-supported-cluster-structure-as-anode-toward-superior-lithium-storage-properties
#11
Chengling Zhu, Zhixin Chen, Shenmin Zhu, Yao Li, Hui Pan, Xin Meng, Muhammad Imtiaz, Di Zhang
Inspired by nature, herein we designed a novel construction of SnO2 anodes with an extremely high lithium storage performance. By utilizing small sheets of graphene oxide, the partitioned-pomegranate-like structure was constructed (SnO2@C@half-rGO), in which the porous clusters of SnO2 nanoparticles are partially supported by reduced graphene oxide sheets while the rest part is exposed (half-supported), like partitioned pomegranates. When served as anode for lithium-ion batteries, SnO2@C@half-rGO exhibited considerably high specific capacity (1034...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28582966/polarization-dependent-quasi-far-field-superfocusing-strategy-of-nanoring-based-plasmonic-lenses
#12
Hao Sun, Yechuan Zhu, Bo Gao, Ping Wang, Yiting Yu
The two-dimensional superfocusing of nanoring-based plasmonic lenses (NRPLs) beyond the diffraction limit in the far-field region remains a great challenge at optical wavelengths. In this paper, in addition to the modulation of structural parameters, we investigated the polarization-dependent focusing performance of a NRPL employing the finite-difference time-domain (FDTD) method. By utilizing the state of polarization (SOP) of incident light, we successfully realize the elliptical-, donut-, and circular-shape foci...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28579665/foxp3-stained-image-analysis-for-follicular-lymphoma-optimal-adaptive-thresholding-with-maximal-nucleus-coverage
#13
C Senaras, M Pennell, W Chen, B Sahiner, A Shana'ah, A Louissaint, R P Hasserjian, G Lozanski, M N Gurcan
Immunohistochemical detection of FOXP3 antigen is a usable marker for detection of regulatory T lymphocytes (TR) in formalin fixed and paraffin embedded sections of different types of tumor tissue. TR plays a major role in homeostasis of normal immune systems where they prevent auto reactivity of the immune system towards the host. This beneficial effect of TR is frequently "hijacked" by malignant cells where tumor-infiltrating regulatory T cells are recruited by the malignant nuclei to inhibit the beneficial immune response of the host against the tumor cells...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28578351/protective-effects-of-microrna-126-on-human-cardiac-microvascular-endothelial-cells-against-hypoxia-reoxygenation-induced-injury-and-inflammatory-response-by-activating-pi3k-akt-enos-signaling-pathway
#14
Hong-Hui Yang, Yan Chen, Chuan-Yu Gao, Zhen-Tian Cui, Jian-Min Yao
OBJECTIVE: This study explored the protective effects of the microRNA-126 (miR-126)-mediated PI3K/Akt/eNOS signaling pathway on human cardiac microvascular endothelial cells (HCMECs) against hypoxia/reoxygenation (H/R)-induced injury and the inflammatory response. METHODS: Untreated HCMECs were selected for the control group. After H/R treatment and cell transfection, the HCMECs were assigned to the H/R, miR-126 mimic, mimic-negative control (NC), miR-126 inhibitor, inhibitor-NC, wortmannin (an inhibitor of PI3K) and miR-126 mimic + wortmannin groups...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28578285/bioinspired-catecholic-activation-of-marine-chitin-for-immobilization-of-ag-nanoparticles-as-recyclable-pollutant-nanocatalysts
#15
Yanwei Wang, Qingshan Kong, Beibei Ding, Yijun Chen, Xiaofei Yan, Shiwei Wang, Fushan Chen, Jun You, Chaoxu Li
Being one type of the most abundant marine polysaccharides in nature, chitin has inert chemical properties and thus prolonged been hindered for high-value utilization. A mussel-inspired catecholic chemistry was found to be able to confer nature-derived mesoporous chitin aerogels with high and tunable surface activities. When further combining with their high porosity, high specific surface area, mechanical toughness and unique nanofibrous architecture, these catechol-activated chitin aerogels could be used as a unique supporting matrix to immobilize Ag nanoparticles...
May 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28571383/an-empirical-correction-for-moderate-multiple-scattering-in-super-heterodyne-light-scattering
#16
Denis Botin, Ludmila Marotta Mapa, Holger Schweinfurth, Bastian Sieber, Christopher Wittenberg, Thomas Palberg
Frequency domain super-heterodyne laser light scattering is utilized in a low angle integral measurement configuration to determine flow and diffusion in charged sphere suspensions showing moderate to strong multiple scattering. We introduce an empirical correction to subtract the multiple scattering background and isolate the singly scattered light. We demonstrate the excellent feasibility of this simple approach for turbid suspensions of transmittance T ≥ 0.4. We study the particle concentration dependence of the electro-kinetic mobility in low salt aqueous suspension over an extended concentration regime and observe a maximum at intermediate concentrations...
May 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28567167/nurse-competence-on-physiologic-monitors-use-toward-eliminating-alarm-fatigue-in-intensive-care-units
#17
Azizeh K Sowan, Ana G Vera, Elma I Fonseca, Charles C Reed, Albert F Tarriela, Andrea E Berndt
BACKGROUND: Studies on nurse competence on alarm management are a few and tend to be focused on limited skills. In response to Phase II of implementing the National Patient Safety Goal on clinical alarm systems safety, this study assessed nurses' perceived competence on physiologic monitors use in intensive care units (ICUs) and developed and validated a tool for this purpose. METHODS: This descriptive study took place in a Magnet hospital in a Southwestern state of the U...
2017: Open Medical Informatics Journal
https://www.readbyqxmd.com/read/28546888/vapor-phase-synthesized-fluoroacrylate-polymer-thin-films-thermal-stability-and-structural-properties
#18
Paul Christian, Anna Maria Coclite
In this study, the thermal, chemical and structural stability of 1H,1H,2H,2H-perfluorodecyl acrylate polymers (p-PFDA) synthetized by initiated chemical vapor deposition (iCVD) were investigated. PFDA polymers are known for their interesting crystalline aggregation into a lamellar structure that induces super-hydrophobicity and oleophobicity. Nevertheless, when considering applications which involve chemical, mechanical and thermal stresses, it is important to know the limits under which the crystalline aggregation and the resulting polymer properties are stable...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28545049/first-cloned-bactrian-camel-camelus-bactrianus-calf-produced-by-interspecies-somatic-cell-nuclear-transfer-a-step-towards-preserving-the-critically-endangered-wild-bactrian-camels
#19
Nisar Ahmad Wani, Binoy S Vettical, Seung B Hong
Studies were conducted to explore the possibility of employing dromedary camel (Camelus dromedarius) oocytes as recipient cytoplasts for the development of interspecies somatic cell nuclear transfer (iSCNT) embryos using skin fibroblast cells of an adult Bactrian camel (Camelus bactrianus) and Llama (Llama glama) as donor nuclei. Also, the embryos reconstructed with Bactrian cells were transferred into the uterus of synchronized dromedary camel recipients to explore the possibility of using them as surrogate mothers...
2017: PloS One
https://www.readbyqxmd.com/read/28534910/synergy-of-the-mechanical-antifouling-and-permeation-properties-of-a-carbon-nanotube-nanohybrid-membrane-for-efficient-oil-water-separation
#20
Yanan Liu, Yanlei Su, Jialin Cao, Jingyuan Guan, Linyan Xu, Rannan Zhang, Mingrui He, Qi Zhang, Lin Fan, Zhongyi Jiang
For water treatment applications, fabricating a high permeation flux membrane with super-strong mechanical strength and excellent long-term antifouling properties remains a great challenge. In this study, robust, antifouling carbon nanotube (CNT) nanohybrid membranes have been fabricated for oil/water separation. Polyethyleneimine (PEI) with abundant amino groups and a hyperbranched structure is utilized to construct a nanocoating on a CNT surface to enhance their hydrophilicity through multiple interactions between PEI and CNTs...
June 8, 2017: Nanoscale
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