keyword
https://read.qxmd.com/read/36345260/acute-liver-failure-in-tropical-infections-thinking-beyond-viral-hepatitis
#21
JOURNAL ARTICLE
Jenisha Jain, Mayank Jain
Acute liver failure is characterised by the presence of jaundice and encephalopathy with or without coagulopathy in a patient with a previously normal liver.1 A variety of tropical infections can lead to this clinical presentation. Hepatosplenomegaly and bleeding manifestations are common in such patients. Deranged liver biochemistry and poor outcomes are hallmarks of viral hepatitis inducing liver failure.
January 2023: Tropical Doctor
https://read.qxmd.com/read/36233805/non-communicable-diseases-the-invisible-epidemic
#22
EDITORIAL
Daniele Piovani, Georgios K Nikolopoulos, Stefanos Bonovas
Historically, communicable diseases, such as HIV/AIDS, viral hepatitis, malaria, poliomyelitis, tuberculosis, influenza and, more recently, the coronavirus disease 2019, have been at the center of global health concerns and initiatives, as they are transmitted from one person to another with a variety of ways, easily spread across national borders, and threaten the lives of millions of people all over the globe [...].
October 8, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36172356/tissue-resident-memory-t-cells-in-chronic-liver-diseases-phenotype-development-and-function
#23
REVIEW
Yikang Li, Zhengrui You, Ruqi Tang, Xiong Ma
Tissue-resident memory (TRM ) T cells are a unique subset of memory T cells that are critical for the first line of defense against pathogens or antigens in peripheral non-lymphoid tissues such as liver, gut, and skin. Generally, TRM cells are well adapted to the local environment in a tissue-specific manner and typically do not circulate but persist in tissues, distinguishing them from other memory T cell lineages. There is strong evidence that liver TRM cells provide a robust adaptive immune response to potential threats...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35715352/vaccines-based-on-the-replication-deficient-simian-adenoviral-vector-chadox1-standardized-template-with-key-considerations-for-a-risk-benefit-assessment
#24
JOURNAL ARTICLE
Pedro M Folegatti, Daniel Jenkin, Susan Morris, Sarah Gilbert, Denny Kim, James S Robertson, Emily R Smith, Emalee Martin, Marc Gurwith, Robert T Chen
Replication-deficient adenoviral vectors have been under investigation as a platform technology for vaccine development for several years and have recently been successfully deployed as an effective COVID-19 counter measure. A replication-deficient adenoviral vector based on the simian adenovirus type Y25 and named ChAdOx1 has been evaluated in several clinical trials since 2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform technology vaccines...
June 14, 2022: Vaccine
https://read.qxmd.com/read/35633442/high-throughput-virtual-screening-of-small-molecule-inhibitors-targeting-immune-cell-checkpoints-to-discover-new-immunotherapeutics-for-human-diseases
#25
JOURNAL ARTICLE
Satyendra Singh, Ketan Kumar, Mamta Panda, Aryan Srivastava, Amit Mishra, Vijay Kumar Prajapati
Immunotherapy is widely used to treat various cancers, and the drugs used are called immune checkpoint (ICP) inhibitors. Overexpression of immune cell checkpoints is reported for other human diseases such as acute infections (malaria), chronic viral infection (HIV, hepatitis B virus, TB infections), allergy, asthma, neurodegeneration, and autoimmune diseases. Some mAbs (monoclonal antibodies) are available against ICPs, but they have side effects. Small molecule seems to be safer in comparison with mAbs. Three independent small-molecule inhibitor libraries consisting of 9466 compounds were screened against seven immune cell checkpoints by applying high-throughput virtual screening approach...
May 28, 2022: Molecular Diversity
https://read.qxmd.com/read/35620544/prevalence-of-hepatitis-b-virus-and-associated-risk-factors-among-adults-patients-at-dessie-referral-and-kemise-general-hospitals-in-northeastern-ethiopia
#26
JOURNAL ARTICLE
Hussein Mohammed, Aragaw Eshetie, Dessie Melese
Background and Aims: Hepatitis is an inflammation of the liver that can reason a variety of health problems and can be fatal. According to the most recent estimates of the Global Burden of Disease study and WHO, viral hepatitis is accountable for around 1.34 million deaths yearly, which is comparable to the yearly number of deaths from HIV/AIDS (1.3 million), malaria (0.9 million), and tuberculosis (1.3 million). This study aimed to assess the prevalence of the Hepatitis B virus and associated risk factors among adults patients at Dessie Referral and Kemise General Hospitals...
May 2022: Health Science Reports
https://read.qxmd.com/read/35490317/neglected-tropical-diseases-ntds-and-covid-19-pandemic-in-africa-special-focus-on-control-strategies
#27
JOURNAL ARTICLE
Abdullahi Tunde Aborode, Emmanuel Adebowale Fajemisin, Emmanuel Ademola Aiyenuro, Muhammad Alakitan, Matthew Olaide Ariwoola, Jegede Oluwatoyin Imisioluwa, Raheemt Rafiu, Athanasios Alexiou
Neglected Tropical Diseases (NTDs) are a group of twenty (20) chronic, communicable, infectious diseases endemic to the tropics and sub-tropics climate countries which are intimately associated with poverty, poor sanitation, limited clean water, and healthcare delivery; and dwellers live in proximity to pathogens and diseases vectors. The pathogens are protozoans, bacteria, helminths, fungi, and viruses. NTDs currently affects about one billion people globally, out of which 500 million are Africans living in rural settlements with low political voice and support...
April 27, 2022: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/35463540/dengue-infection-with-warning-signs-the-2019-epidemic
#28
JOURNAL ARTICLE
Vishal Singh, Satish Chandra Mishra, Nikesh Ashok Agarwal, Pradeepa Adgoor Mallikarjuna, Binod Biswajeet Raut
Background: Dengue is a common arthropod-borne viral disease with a variable clinical spectrum, course, and outcome. Method: We conducted a prospective observational study describing the clinical profile of patients hospitalized for dengue with warning signs during the 2019 epidemic. Result: A total of 1349 patients with dengue, including 459 with warning signs, were seen. It predominantly affects the younger subset of both sexes. A higher proportion of females presented with either a platelet count less than 20,000/mm3 or a rapid fall in platelets...
April 2022: Medical Journal, Armed Forces India
https://read.qxmd.com/read/35110854/analysis-of-causes-of-hepatic-dysfunction-in-obstetric-patients-in-india-a-systematic-review
#29
REVIEW
Armin Ahmed, Sulekha Saxena, Amita Pandey, Prabhakar Mishra, Afzal Azim
BACKGROUND: Epidemiology of liver disease in obstetric patients shows geographical variation depending upon the prevalence of preeclampsia, viral hepatitis, and tropical vector-borne diseases like malaria, leptospirosis, etc. We undertook the current systematic review to analyze the causes of hepatic dysfunction in obstetric patients in India and identify the gaps in the literature and reporting. MATERIALS AND METHODS: We did a systematic review of studies reporting the causes of hepatic dysfunction in obstetric patients in India...
January 2022: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/34872062/screening-for-chronic-infectious-diseases-by-serology-in-those-presenting-with-malaria-in-london-united-kingdom
#30
JOURNAL ARTICLE
Alison Gowland, Emma McGuire, Anna L Goodman
The United Kingdom's cases of malaria infection are primarily acquired in sub-Saharan Africa, with the majority of infections presenting in London.1 When patients go to a hospital with malaria, there is a screening opportunity for other geographically associated chronic infections. We identified patients who were diagnosed with malaria after presenting to our emergency department in London over a 2-year period, to assess whether there may be clinical benefit in screening for chronic viral (hepatitis B, hepatitis C, HIV) or parasitic (schistosomiasis, strongyloidiasis) infection in this cohort...
December 6, 2021: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/34814578/-introduction-of-world-health-organization-strategies-and-the-technical-advisory-committee-actions-on-viral-hepatitis-control-and-status-of-the-elimination-of-viral-hepatitis-in-china
#31
JOURNAL ARTICLE
F Q Cui, F Z Wang, H Zheng, X F Liang
Viral hepatitis has been causing big threat to public health globally. The number of annual deaths caused by hepatitis surpassed the deaths caused by AIDS, tuberculosis, and malaria. World Health Organization (WHO) issued the global health sector strategy on viral hepatitis 2016-2020 (GHSS) to control its epidemic. It established the Strategies and Technical Advisory Committee on HIV, viral hepatitis, and sexually transmitted infections (STAC). This paper summarizes the GHSS goals and the keynote of the 2020 STAC meeting, analyzes the challenges and opportunities faced by China in eliminating viral hepatitis, and provides the comments on the papers on this issue, which could guide further actions...
September 10, 2021: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://read.qxmd.com/read/34806818/improving-disease-knowledge-is-critical-to-eliminate-hepatitis-b
#32
JOURNAL ARTICLE
Maud Lemoine, Gibril Ndow, Yusuke Shimakawa
Despite its high burden of disease, viral hepatitis B has been long neglected and still receives little public attention and political support as compared to other infectious diseases (e.g HIV, tuberculosis, malaria). Prevention of hepatitis B virus (HBV) mother-to-child transmission (MTCT), a key component to achieve HBV elimination, relies on antiviral therapy of highly viremic HBV-infected pregnant women and HBV vaccination at birth of their babies1 . In its elimination plan, the World Health Organisation (WHO) called for a major increase in coverage of vaccination (90%), diagnosis (90%) and treatment (80%) by 2030...
November 22, 2021: Journal of Viral Hepatitis
https://read.qxmd.com/read/34804418/thymoquinone-against-infectious-diseases-perspectives-in-recent-pandemics-and-future-therapeutics
#33
REVIEW
Mousumi Tania, Asaduzzaman Asad, Tian Li, Md Shariful Islam, Shad Bin Islam, Md Munnaf Hossen, Mizanur Rahman Bhuiyan, Md Asaduzzaman Khan
The recent pandemics caused by coronavirus infections have become major challenges in 21st century human health. Scientists are struggling hard to develop a complete cure for infectious diseases, for example, drugs or vaccines against these deadly infectious diseases. We have searched papers on thymoquinone (TQ) and its effects on different infectious diseases in databases like Pubmed, Web of Science, Scopus, and Google Scholar, and reviewed them in this study. To date research suggests that natural products may become a potential therapeutic option for their prodigious anti-viral or anti-microbial effects on infectious diseases...
August 2021: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/34755343/insight-of-oral-vaccines-as-an-alternative-approach-to-health-and-disease-management-an-innovative-intuition-and-challenges
#34
REVIEW
Nabendu Debnath, Mony Thakur, Khushboo, Neelam P Negi, Vibhav Gautam, Ashok Kumar Yadav, Deepak Kumar
Vaccination is the most suitable and persuasive healthcare program for the prohibition of various deadly diseases. However, the higher production cost and purification strategies are out of reach for the developing nations. In this scenario, development of edible vaccine turns out to be the most promising alternative for remodeling the pharmaceutical industry with reduced production and purification costs. Generally, oral route of vaccination is mostly preferred due to its safety, compliance, low manufacturing cost and most importantly the ability to induce immunity in both systemic and mucosal sites...
February 2022: Biotechnology and Bioengineering
https://read.qxmd.com/read/34728344/ultra-long-acting-xla-antivirals-for-chronic-viral-hepatitis
#35
JOURNAL ARTICLE
Vicente Soriano, Carmen Alvarez, Benson Edagwa, Carmen de Mendoza, Noemí Montoya, Ana Treviño, Howard Gendelman
Viral hepatitis is among the top four causes of mortality globally, causing 1.4 million deaths each year, exceeding tuberculosis, malaria and human immunodeficiency virus. Hepatitis B and C are responsible for 90% of hepatitis deaths, and the remaining 10% are caused by other hepatitis viruses. The annual number of deaths from hepatitis C is declining, whereas the numbers of deaths from hepatitis B and D are increasing. Hepatitis B alone represents the seven highest cause of mortality worldwide. Spurred on by development of curative antivirals for hepatitis C and expanding access to hepatitis B virus (HBV) vaccination, the World Health Organization has committed to eliminating viral hepatitis as a public health threat by 2030...
January 2022: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/34508669/health-care-provision-and-policy-for-non-alcoholic-fatty-liver-disease-in-sub-saharan-africa
#36
REVIEW
C Wendy Spearman, Abdelmounem Abdo, Aggrey Ambali, Yaw A Awuku, Chris Kassianides, Olufunmilayo A Lesi, Margareth Ndomondo-Sigonda, Charles A Onyekwere, John Rwegasha, Abate B Shewaye, Mark W Sonderup
Sub-Saharan Africa, which has a population of more than 1 billion people, carries 24% of the global burden of disease and spends the least on health care of any region, relying heavily on international development assistance to deliver health care for HIV, tuberculosis, and malaria. The demographic and epidemiological transitions occurring in sub-Saharan Africa, with rising prevalences of obesity and diabetes, enhance the risk of non-alcoholic fatty liver disease (NAFLD), yet this remains an unrecognised complication of metabolic syndrome...
September 8, 2021: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/34466115/association-of-blood-groups-with-hepatitis-c-viremia
#37
JOURNAL ARTICLE
Mahnoor, Mamoona Noreen, Muhammad Imran, Sher Zaman Safi, Muhammad Amjad Bashir, Afrah Fahad Alkhuriji, Suliman Yousef Alomar, Hanan Mualla Alharbi
Hepatitis C virus remained a public health problem with approximately half of the patients untreated and undiagnosed. Chronic HCV is a leading cause of cirrhosis, fibrosis, hepatocellular carcinoma and other hepatic morbidities. Active HCV has a prevalence rate of about 1% (71 million). By July, 2019, 10 million population of Pakistan was declared to have active HCV infection. According to World Health Organization, 23,720 people died of hepatitis-related complexities in Pakistan in 2016. Individuals with certain types of ABO blood groups were more susceptible to diverse kinds of infections...
September 2021: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/34395197/prevalence-of-hepatitis-b-and-c-among-healthcare-workers-in-a-tertiary-care-center-in-monrovia-liberia
#38
JOURNAL ARTICLE
Whitney Lieb, Yassah Moracious Barclay-Korboi, Christopher Dike, Amrin Khander, Samantha Raymond, Tatyana Kushner, Ann Marie Beddoe
Background: Viral hepatitis is a leading cause of death worldwide, with a higher mortality rate than that from human immunodeficiency virus (HIV), tuberculosis (TB) or malaria. In order to meet the WHO's goal of eliminating hepatitis B and C by 2030, there is a dire need to establish baseline prevalence rates and increase public health awareness of this detrimental disease, especially in low and middle-income countries (LMICs) where establishing prevalence rates of hepatitis B (HBV) and hepatitis (HCV) continues to be a problem...
2021: Annals of Global Health
https://read.qxmd.com/read/34326610/progress-and-challenges-in-the-comprehensive-management-of-chronic-viral-hepatitis-key-ways-to-achieve-the-elimination
#39
REVIEW
Fátima Higuera-de la Tijera, Alfredo Servín-Caamaño, Luis Servín-Abad
Chronic viral hepatitis is a significant health problem throughout the world, which already represents high annual mortality. By 2040, chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria, vitellogenesis-inhibiting hormone, and tuberculosis altogether. In this review, we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups, the goals set by the World Health Organization for the year 2030, and the key points to achieve them, such as timely access to antiviral treatment of direct-acting antiviral, which represents the key to achieving hepatitis C virus elimination...
July 14, 2021: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/34267829/a-focused-review-on-recent-advances-in-the-diagnosis-and-treatment-of-viral-hepatitis
#40
REVIEW
Wei Zhang, Mahmoud Aryan, Steve Qian, Roniel Cabrera, Xiuli Liu
The global burden of viral hepatitis remains substantial despite advances in antiviral therapy and effective vaccines. There are five hepatitis viruses (hepatitis A, B, C, D, and E). Mortality related to hepatitis B virus and hepatitis C virus infections is among the top four global infectious diseases, together with human immunodeficiency virus infection, malaria, and tuberculosis. Of those deaths, approximately 47% are attributable to hepatitis B virus, 48% to hepatitis C virus and the remainder to hepatitis A virus and hepatitis E virus...
June 2021: Gastroenterology Research
keyword
keyword
27290
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.