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https://www.readbyqxmd.com/read/28640891/baculoviral-delivery-of-crispr-cas9-facilitates-efficient-genome-editing-in-human-cells
#1
Sanne Hindriksen, Arne J Bramer, My Anh Truong, Martijn J M Vromans, Jasmin B Post, Ingrid Verlaan-Klink, Hugo J Snippert, Susanne M A Lens, Michael A Hadders
The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonly used viral vectors suffer from a limited capacity in the genetic information they can carry. Baculovirus however is capable of carrying large exogenous DNA fragments. Here we investigate the use of baculoviral vectors as a delivery vehicle for CRISPR/Cas9 based genome-editing tools...
2017: PloS One
https://www.readbyqxmd.com/read/28636581/the-psylog-mobile-application-development-of-a-tool-for-the-assessment-and-monitoring-of-side-effects-of-psychotropic-medication
#2
Martina Rojnic Kuzman, Olivier Andlauer, Kai Burmeister, Boris Dvoracek, Rebekka Lencer, Katja Koelkebeck, Alexander Nawka, Florian Riese
Mobile health interventions are regarded as affordable and accessible tools that can enhance standard psychiatric care. As part of the mHealth Psycho-Educational Intervention Versus Antipsychotic-Induced Side Effects (mPIVAS) project (www.psylog.eu), we developed the mobile application "PsyLOG" based on mobile "smartphone" technology to monitor antipsychotic-induced side effects. The aim of this paper is to describe the rationale and development of the PsyLOG and its clinical use. The PsyLOG application runs on smartphones with Android operating system...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28635949/non-coding-variants-contribute-to-the-clinical-heterogeneity-of-ttr-amyloidosis
#3
Andrea Iorio, Antonella De Lillo, Flavio De Angelis, Marco Di Girolamo, Marco Luigetti, Mario Sabatelli, Luca Pradotto, Alessandro Mauro, Anna Mazzeo, Claudia Stancanelli, Federico Perfetto, Sabrina Frusconi, Filomena My, Dario Manfellotto, Maria Fuciarelli, Renato Polimanti
Coding mutations in TTR gene cause a rare hereditary form of systemic amyloidosis, which has a complex genotype-phenotype correlation. We investigated the role of non-coding variants in regulating TTR gene expression and consequently amyloidosis symptoms. We evaluated the genotype-phenotype correlation considering the clinical information of 129 Italian patients with TTR amyloidosis. Then, we conducted a re-sequencing of TTR gene to investigate how non-coding variants affect TTR expression and, consequently, phenotypic presentation in carriers of amyloidogenic mutations...
June 21, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28635484/political-losses
#4
Stephanie Glanville
I am gutted Labour didn't win the election, as they promised to reintroduce the bursary. I put my nursing degree on hold for 16 months due to my daughter's illness. The new term begins in September, but I have lost my bursary and maintenance grant entitlement. I can no longer afford to do the course.
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635483/student-life-imposter-syndrome
#5
Mandy Day-Calder
I will never forget the first time I stepped onto a ward as a nursing student in my freshly ironed new uniform. Everything was going well. This was it, I was living my dream. And then an older woman called out for a nurse, looked at me, and I froze. I wasn't a 'real' nurse, so what on earth was I to do?
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635468/a-smile-to-help-in-the-tough-times
#6
Harriet Pollard
At the start of my second year of training I was working on a cardiac ward where I helped to care for a young teenager who was awaiting surgery.
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635450/you-don-t-have-to-know-the-answers-to-write-poetry
#7
Molly Case
It's a great pleasure to be able to spend the next six months as the RCN's first ever writer in residence. My role is part of an exciting new project at the RCN Library and Archive called Service Scrapbooks: Nursing, Storytelling and the First World War, which is funded by a £60,600 grant from the Heritage Lottery Fund.
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635445/-my-diabetes-nurse-has-always-gone-beyond-the-call-of-duty
#8
(no author information available yet)
Three years ago I nearly died from complications related to diabetes, but specialist nurse Kathy Taylor, pictured, and her excellent team helped to save my life.
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28634823/a-nationwide-study-of-the-incidence-rate-of-herb-induced-liver-injury-in-korea
#9
Jung-Hyo Cho, Dal-Seok Oh, Sang-Hoon Hong, Heung Ko, Nam-Hun Lee, Sang-Eun Park, Chang-Woo Han, Seung-Mo Kim, Young-Chul Kim, Kang-San Kim, Chang-Won Choi, Seon-My Shin, Ki-Tae Kim, Hong-Sik Choi, Jang-Hoon Lee, Jun-Young Kim, Ji-Young Kang, Dong-Soo Lee, Yo-Chan Ahn, Chang-Gue Son
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7...
June 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28634766/political-minimalism-and-social-debates-the-case-of-human-enhancement-technologies
#10
Javier Rodríguez-Alcázar
A faulty understanding of the relationship between morality and politics encumbers many contemporary debates on human enhancement. As a result, some ethical reflections on enhancement undervalue its social dimensions, while some social approaches to the topic lack normative import. In this essay, I use my own conception of the relationship between ethics and politics, which I call "political minimalism," in order to support and strengthen the existing social perspectives on human-enhancement technologies.
June 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28634660/should-i-convince-my-partner-to-go-on-pre-exposure-prophylaxis%C3%A2-prep-the-role-of-personal-and-relationship-factors-on-prep-related-social-control-among-gay-and-bisexual-men
#11
Steven A John, Tyrel J Starks, H Jonathon Rendina, Christian Grov, Jeffrey T Parsons
An estimated 35-68% of new HIV infections among gay, bisexual, and other men who have sex with men (GBM) are transmitted through main partnerships. Pre-exposure prophylaxis (PrEP) is highly effective in reducing HIV seroconversion, yet PrEP uptake has been modest. PrEP-naïve GBM with HIV-negative, PrEP-naïve main partners enrolled in One Thousand Strong (n = 409), a U.S. national cohort of GBM, were asked about (1) the importance of partner PrEP use and (2) their willingness to convince their partner to initiate PrEP...
June 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28633510/in-reply-stereotactic-radiosurgery-for-cystic-vestibular-schwannomas
#12
Michael J Link
No abstract text is available yet for this article.
June 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28632079/-no-there-is-nothing-wrong-with-your-eyes-my-letterhead-is-indeed-crooked-an-introduction-to-the-study-of-black-and-brown-lesbian-educators
#13
Bettina L Love
To date, there is a noticeable lack of studies that focus exclusively on the pedagogical practices, teaching experiences, identity, and gender performances of Black and Brown lesbian educators (BBLE). This special issue of the Journal of Lesbian Studies aims to make the hyperinvisibility of BBLE visible and proposes to fill this scholarly gap by exploring this topic from a variety of cultural and disciplinary perspectives.
September 22, 2016: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28631730/finding-freedom-from-fecal-incontinence-with-my-orange-tote
#14
Sigrid LaFata, Stacy B Menees
No abstract text is available yet for this article.
June 20, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28631727/my-approach-to-fecal-incontinence-it-s-all-about-consistency-stool-that-is
#15
Stacy B Menees
No abstract text is available yet for this article.
June 20, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28631327/say-hello-to-my-little-friends-how-microbiota-can-modulate-tree-health
#16
Nicolas Feau, Richard C Hamelin
No abstract text is available yet for this article.
July 2017: New Phytologist
https://www.readbyqxmd.com/read/28630326/reconstruction-and-evolutionary-history-of-eutherian-chromosomes
#17
Jaebum Kim, Marta Farré, Loretta Auvil, Boris Capitanu, Denis M Larkin, Jian Ma, Harris A Lewin
Whole-genome assemblies of 19 placental mammals and two outgroup species were used to reconstruct the order and orientation of syntenic fragments in chromosomes of the eutherian ancestor and six other descendant ancestors leading to human. For ancestral chromosome reconstructions, we developed an algorithm (DESCHRAMBLER) that probabilistically determines the adjacencies of syntenic fragments using chromosome-scale and fragmented genome assemblies. The reconstructed chromosomes of the eutherian, boreoeutherian, and euarchontoglires ancestor each included >80% of the entire length of the human genome, whereas reconstructed chromosomes of the most recent common ancestor of simians, catarrhini, great apes, and humans and chimpanzees included >90% of human genome sequence...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629652/the-history-of-science-as-the-progress-of-the-human-spirit-the-historiography-of-astronomy-in-the-eighteenth-century
#18
Daniel Špelda
In the eighteenth century, the historiography of astronomy was part of a wider discussion concerning the history of the human spirit. The concept of the human spirit was very popular among Enlightenment authors because it gave the history of human knowledge continuity, unity and meaning. Using this concept, scientists and historians of science such as Montucla, Lalande, Bailly and Laplace could present the history of astronomy in terms of a progress towards contemporary science that was slow and could be interrupted at times, but was still constant, regular, and necessary...
June 2017: Studies in History and Philosophy of Science
https://www.readbyqxmd.com/read/28629224/-it-s-not-my-business-exploring-heteronormativity-in-young-people-s-discourses-about-lesbian-gay-bisexual-transgender-and-queer-issues-and-their-implications-for-youth-health-and-wellbeing
#19
Cara Ky Ng, Rebecca J Haines-Saah, Rodney E Knight, Jean A Shoveller, Joy L Johnson
In Canada, the issue of creating safe and inclusive school environments for lesbian, gay, bisexual, transgender, and queer students has been in the spotlight. Several researchers and advocates have pointed out the positive effects of lesbian, gay, bisexual, transgender, and queer-positive policy frameworks on the health and wellbeing of all young people. In this article, we take a critical approach to analyzing narrative findings from qualitative interviews conducted with youth in three communities in British Columbia, Canada: "the North," Vancouver, and Abbotsford...
June 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28628099/toxoplasma-depends-on-lysosomal-consumption-of-autophagosomes-for-persistent-infection
#20
Manlio Di Cristina, Zhicheng Dou, Matteo Lunghi, Geetha Kannan, My-Hang Huynh, Olivia L McGovern, Tracey L Schultz, Aric J Schultz, Alyssa J Miller, Beth M Hayes, Wouter van der Linden, Carla Emiliani, Matthew Bogyo, Sébastien Besteiro, Isabelle Coppens, Vern B Carruthers
Globally, nearly 2 billion people are infected with the intracellular protozoan Toxoplasma gondii(1). This persistent infection can cause severe disease in immunocompromised people and is epidemiologically linked to major mental illnesses(2) and cognitive impairment(3). There are currently no options for curing this infection. The lack of effective therapeutics is due partly to a poor understanding of the essential pathways that maintain long-term infection. Although it is known that Toxoplasma replicates slowly within intracellular cysts demarcated with a cyst wall, precisely how it sustains itself and remodels organelles in this niche is unknown...
June 19, 2017: Nature Microbiology
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