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https://www.readbyqxmd.com/read/29777748/a-brief-practical-review-of-size-exclusion-chromatography-rules-of-thumb-limitations-and-troubleshooting
#1
REVIEW
Richard R Burgess
Through years of research, teaching, troubleshooting, and editing, I have developed a solid working understanding of many aspects of protein purification and protein biochemistry. I have also found that many researchers do not understand the basics, let alone the pitfalls, of the techniques they use. In the case of size exclusion chromatography (SEC), I summarize below some of the rules of thumb, suggestions, limitations and troubleshooting I have found most useful in helping my students and colleagues carry out successful SEC...
May 16, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29777087/physiotherapy-complements-my-nursing
#2
(no author information available yet)
Rachael McCooey is a physiotherapist and a registered veterinary nurse with Severn Veterinary Centre.
May 19, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29775459/on-the-role-of-sparseness-in-the-evolution-of-modularity-in-gene-regulatory-networks
#3
Carlos Espinosa-Soto
Modularity is a widespread property in biological systems. It implies that interactions occur mainly within groups of system elements. A modular arrangement facilitates adjustment of one module without perturbing the rest of the system. Therefore, modularity of developmental mechanisms is a major factor for evolvability, the potential to produce beneficial variation from random genetic change. Understanding how modularity evolves in gene regulatory networks, that create the distinct gene activity patterns that characterize different parts of an organism, is key to developmental and evolutionary biology...
May 18, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29774987/an-increased-percentage-of-myeloid-cd34-bone-marrow-cells-stratifies-intermediate-ipss-r-myelodysplastic-syndrome-patients-into-prognostically-significant-groups
#4
T-H Chen-Liang, A M Casado-Prieto, V Campos-Rodríguez, A M Hurtado, M L Amigo, M D García-Malo, V Vicente, F J Ortuño, A Jerez
INTRODUCTION: The Revised International Prognostic Scoring System (IPSS-R) for myelodysplastic syndromes (MDS) has established an intermediate category where a disease-modifying intervention is a matter of debate. Flow cytometry allows us to determine a fraction of immature myeloid cells in a semiautomated procedure. The aim of this study, mirroring IPSS-R study inclusion criteria, was to test whether bone marrow (BM) CD34+My percentage has independent prognostic value in the MDS setting...
May 18, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29774313/echoes-from-the-40-th-annual-san-antonio-breast-cancer-symposium-2017
#5
Bekir Kuru
The Annual San Antonio Symposium was held on 5-9, December, 2017 in San Antonio, Texas, USA (1). As expected, many new studies were presented for the first time at the sessions. The unofficial opening lecture in my point of view was given on locoregional recurrence by Monica Morrow from MSKCC, New York. As always, Morrow's lecture on "Challenges in the surgical management of locoregional recurrence" attracted great interest. The other prominent conferences were given on "Individualizing Management of the Axillary Nodes" by Tari A...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29773480/must-i-respond-if-my-health-is-at-risk
#6
Kenneth V Iserson
BACKGROUND: Widespread epidemics, pandemics, and other risk-prone disasters occur with disturbing regularity. When such events occur, how should, and will, clinicians respond? The moral backbone of medical professionals-a duty to put the needs of patients first-may be sorely tested. DISCUSSION: It is incumbent on health care professionals to ask what we must do and what we should do if a dangerous health care situation threatens both ourselves and our community...
May 14, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29771551/interpersonal-processes-and-intimacy-among-men-with-localized-prostate-cancer-and-their-partners
#7
Sharon Manne, Deborah A Kashy, Talia Zaider, David Lee, Isaac Y Kim, Carolyn Heckman, Frank Penedo, David Kissane, Shannon Myers Virtue
The present study focused on intimacy processes in the relationships of men diagnosed with localized prostate cancer and their partners. Using the actor-partner interdependence model (APIM), we examined the interpersonal process model of intimacy, which proposes associations between self- and perceived partner disclosure about cancer and perceived partner responsiveness as predictors of global relationship intimacy. The study's outcomes were patients' and spouses' ratings of global relationship intimacy. Both actor (my disclosure predicts my intimacy) and partner (my partner's disclosure predicts my intimacy) effects were examined, as well as possible moderating effects for cancer-related concerns...
May 17, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29770140/seventeen-year-journey-working-with-a-master
#8
Jinfang Zhu
It had been a great honor for me to work with the late Dr. William E. Paul for 17 years in the Laboratory of Immunology (LI) from 1998 until his passing in 2015. He was such a master in the immunology field. Under his outstanding guidance, my research has been focusing on transcriptional regulation of T helper (Th) cell differentiation, especially, on the role of a master transcription factor GATA3 during Th2 cell differentiation. Just as enormous scientific contributions of Dr. Paul (we all call him Bill) to the immunology community are far beyond his serving as the Chief of the LI, GATA3 also plays important roles in different lymphocytes at various developmental stages besides its critical functions in Th2 cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29770102/rolling-out-hiv-antiretroviral-therapy-in-sub-saharan-africa-2003-2017
#9
G Taylor
Multiple issues need to be addressed in order to control the HIV pandemic in sub-Saharan Africa. Combination antiretroviral therapy (cART) is key to reducing morbidity and mortality among people living with HIV and has a role in preventing HIV transmission. However, access to cART is very unevenly distributed globally, especially in sub-Saharan Africa. Although cost of cART is no longer a major barrier as effective treatment can be had for under US$100 per year, HIV management is compromised by the inadequate number of trained clinicians, the lack of clinical and laboratory infrastructure and the increased prevalence of co-morbidities (e...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769718/ankrd16-prevents-neuron-loss-caused-by-an-editing-defective-trna-synthetase
#10
My-Nuong Vo, Markus Terrey, Jeong Woong Lee, Bappaditya Roy, James J Moresco, Litao Sun, Hongjun Fu, Qi Liu, Thomas G Weber, John R Yates, Kurt Fredrick, Paul Schimmel, Susan L Ackerman
Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars sti mutant mice results in an increase in the production of serine-mischarged tRNAAla and the degeneration of cerebellar Purkinje cells. Here, using positional cloning, we identified Ankrd16, a gene that acts epistatically with the Aars sti mutation to attenuate neurodegeneration. ANKRD16, a vertebrate-specific protein that contains ankyrin repeats, binds directly to the catalytic domain of AlaRS...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769510/surgical-management-of-a-critical-ischemic-mitral-regurgitation-patient
#11
S A Sunny, S Moinuddin, A B Adhikary, M A Hossain
Functional ischemic mitral regurgitation is strongly associated with poor outcomes in patient with coronary artery disease. The best management for mitral regurgitation at the time of coronary revascularization remains controversial. We report, a case of 58 years-old men admitted to GKNM hospital, Coimbatore, Tamil Nadu, India with chest pain and respiratory distress for last 6 hours during my fellowship training in that hospital. ECG showed acute antero-septal MI. The transthoracic echocardiogram revealed severe left ventricular dysfunction with moderate mitral regurgitation...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768631/distal-nerve-transfers-a-perspective-on-the-future-of-reconstructive-microsurgery
#12
David Chwei-Chin Chuang
BACKGROUND:  Nerve transfer can be broadly separated into two categories: proximal nerve graft and/or transfer and distal nerve transfer. The superiority of proximal nerve graft/transfer over distal nerve transfer strategy has been debated extensively, but which strategy is the best has not yet been defined. Each technique has its own advantages and disadvantages. However, proximal nerve graft/transfer is still the main reconstructive procedure based on the principle of "no diagnosis, then no treatment...
May 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29767529/fractal-gold-nanoframework-for-highly-stretchable-transparent-strain-insensitive-conductors
#13
My Duyen Ho, Yiyi Liu, Dashen Dong, Yunmeng Zhao, Wenlong Cheng
Percolation networks of one-dimensional (1D) building blocks (e.g., metallic nanowires or carbon nanotubes) represent the mainstream strategy to fabricate stretchable conductors. One of the inherent limitations is the control over junction resistance between 1D building blocks in natural and strained states of conductors. Herein, we report highly stretchable transparent strain-insensitive conductors using fractal gold (F-Au) nanoframework based on a one-pot templateless wet chemistry synthesis method. The monolayered F-Au nanoframework (∼20 nm in thickness) can be obtained from the one-pot synthesis without any purification steps involved and can be transferred directly to arbitrary substrates like polyethylene terephthalate, food-wrap, polydimethylsiloxane (PDMS), and ecoflex...
May 16, 2018: Nano Letters
https://www.readbyqxmd.com/read/29767387/no-medication-for-my-child-a-naturalistic-study-on-the-treatment-preferences-for-and-effects-of-cogmed-working-memory-training-versus-psychostimulant-medication-in-clinically-referred-youth-with-adhd
#14
Peter Muris, Dorien Roodenrijs, Lut Kelgtermans, Sonja Sliwinski, Ulrike Berlage, Hanna Baillieux, Anne Deckers, Marieke Gunther, Bertien Paanakker, Ida Holterman
In this naturalistic clinical study, we explored the applicability and clinical effectiveness of Cogmed WMT, pharmacotherapy, and their combination for clinically referred children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Ninety youth with ADHD (ages 6-16 years) and their parents were offered the possibility to choose one of the three interventions. The motives for choosing various interventions were quite different. Medication was chosen because this treatment was expected to be most effective, but also because the Cogmed WMT program was regarded as too taxing...
May 16, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29767163/response-of-primiparous-and-multiparous-buffaloes-to-yeast-culture-supplementation-during-early-and-mid-lactation
#15
Hanne H Hansen, Nasr E El-Bordeny, Hossam M Ebeid
Strains of live Saccharomyces cerevisiae yeast have exhibited probiotic effects in ruminants. This study investigated the effects of the dietary yeast supplement, S . cerevisiae (Yea-Sacc1026 ), on primiparous (PP) and multiparous (MP) Egyptian buffaloes in early to mid-lactation. Lactating buffaloes were fed either a basal total mixed ration (TMR, control; 4 PP and 8 MP) or the basal TMR plus 10 g Yea-Sacc1026 per buffalo cow per day (yeast; 4 PP and 8 MP). The feeds were given from 15 days prepartum to 180 days postpartum...
December 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766727/-human-life-as-goodness-why-euthanasia-is-morally-unacceptable
#16
David Černý
The current discussion of the moral admissibility or inadmissibility of euthanasia should, in my opinion, consider the greatest possible number of the shared premises of the two opinion camps. That is why I followed a thesis in this paper that the question of the good life is the focus of ethical interest, as this is what connects the advocates and the opponents to euthanasia. In the first part of the paper I critically discuss the two main theories of the good life widely embraced among the advocates of euthanasia: hedonism and desire-fulfilment theory...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29766726/-euthanasia-and-the-good-life-why-euthanasia-is-sometimes-ethical
#17
David Černý
In this paper I present the strongest argument, in my opinion, in favour of moral admissibility of euthanasia. In the introduction I briefly mention two important arguments in support of euthanasia - out of respect for autonomy and as a last act of grace, however I refuse them as insufficient. I propose a definition of both forms of assisted death: euthanasia and assisted suicide. I present the basic ideas underlying the theory of the good life and deal with hedonism in greater depth. I define a deprivation concept of the badness of death and, employing hedonism, I specifically describe when death is bad and when it is good...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29766668/thermally-stable-high-performance-polymer-solar-cells-enabled-by-interfacial-engineering
#18
Chao-Hsuan Chen, Zhi-Wei Lin, Kuan-Min Huang, Hsin-Fei Meng, Ziyi Ge, Hsiao-Wen Zan, Chih-Yu Chang, Yu-Chiang Chao, Sheng-Fu Horng
Interfacial engineering plays an important role in determining the performance and stability of polymer solar cells (PSCs). In this study, we demonstrate thermally stable highly-efficient PSCs by incorporating solution-processed cathode interfacial layer (CIL), including 4,4'-(((methyl(4-sulphonatobutyl)ammonio) bis(propane-3,1-diyl)) bis(dimethyl-ammoniumdiyl)) bis-(butane-1-sulphonate) (MSAPBS) and polyethylenimine (PEI). For PSCs based on blends of poly [4,8-bis (5-(2-ethyl-hexyl) thiophen-2-yl) benzo [1,2-b;4,5-b'] dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]thiophene-2-carboxylate-2,6-diyl)] (PBDTTT-EFT) and [6,6]-phenyl C71-butyric acid methyl ester (PC71BM), the maximum power conversion efficiency (PCE) of inverted PSCs reaches 8...
May 16, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29765736/crystal-structure-of-2-isopropyl-4-meth-oxy-5-methyl-phenyl-4-methyl-benzene-sulfonate
#19
Yassine Laamari, Aziz Auhmani, My Youssef Ait Itto, Jean-Claude Daran, Abdelwahed Auhmani, Mostafa Kouili
The title compound, C18 H22 O4 S, an hemisynthetic product, was obtained by the tosyl-ation reaction of the naturally occurring meroterpene p -meth-oxy-thymol. The mol-ecule comprises a tetra-substitued phenyl ring linked to a toluene-sulfonate through one of its O atoms. In the crystal, C-H⋯O and C-H⋯π inter-actions link the mol-ecules, forming a three-dimensional network.
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765327/cardiovascular-adaptive-homeostasis-in-exercise
#20
Kelvin J A Davies
Adaptive Homeostasis has been defined as, "The transient expansion or contraction of the homeostatic range in response to exposure to sub-toxic, non-damaging, signaling molecules or events, or the removal or cessation of such molecules or events." (Davies, 2016). I propose that one of the most significant examples of adaptive homeostasis may be the adaptation of the cardiovascular system to exercise training. In particular, endurance type training involves the generation of increased levels of free radicals such as ubisemiquinone, superoxide, nitric oxide, and other (non-radical) reactive oxygen species such as hydrogen peroxide (H2 O2 ), in a repetitive manner, typically several times per week...
2018: Frontiers in Physiology
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