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https://www.readbyqxmd.com/read/29779240/synthesis-characterization-and-reactivity-of-3-mercaptopyruvic-acid
#1
Erwan Galardon, Jean-Chrstophe Lec
A synthesis of the sulfur metabolic compound 3-mercaptopyruvic acid (3-MPH) is reported and allowed its isolation and characterization for the first time. Detailed kinetic, thermodynamic and spectroscopic studies of its complex behaviour in solution are discussed.
May 20, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29777288/time-shifting-effects-of-methylphenidate-on-daily-rhythms-in-the-diurnal-rodent-arvicanthis-ansorgei
#2
Jorge Mendoza, Hester C van Diepen, Rob Rodrigues Pereira, Johanna H Meijer
People suffering of attention-deficit/hyperactivity disorder (ADHD) and treated with the psychostimulant methylphenidate (MPH) show sleep-wake cycle and daily rhythm alterations despite the beneficial effects of MPH on behavioral symptoms (i.e., hyperactivity, attention). In nocturnal rodents (i.e., mice), chronic exposure to MPH alters the neural activity of the circadian clock in the suprachiasmatic nucleus (SCN), behavioral rhythms, and the sleep-wake cycle. Here, we studied the effects of MPH on daily rhythms of behavior and body temperature of the diurnal rodent Arvicanthis ansorgei...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29773778/a-collaboration-to-teach-us-mph-students-about-cuba-s-health-care-system
#3
Joan O'Connell, Ana María Gálvez-González, Jean Scandlyn, María R Sala-Adam, Xiomara Martín-Linares
In 2011, the US Department of the Treasury changed its regulations to allow US students to participate in short-term education programs in Cuba. Beginning in 2012, and each year thereafter, Cuba's National School of Public Health and the Colorado School of Public Health have jointly taught a class on the Cuban public health system. The program goals are to provide US students with an opportunity to learn about the Cuban national health system's focus on 1) prevention and primary health care services; 2) financial and geographic access to services and health equity; 3) continuum of care across the home, family doctor-and-nurse offices, polyclinics and hospitals; 4) data collection at all levels to understand health risks, including outbreaks, and to guide resource allocation; 5) assessing patients' health and risks using a comprehensive definition of health; 6) multisectoral collaborations between the Ministry of Public Health and other Cuban agencies and organizations to address population health risks; 7) disaster preparedness, response and recovery; and 8) provision of international health assistance...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29769708/maternal-supraphysiological-hypercholesterolemia-associates-with-endothelial-dysfunction-of-the-placental-microvasculature
#4
Bárbara Fuenzalida, Bastián Sobrevia, Claudette Cantin, Lorena Carvajal, Rocío Salsoso, Jaime Gutiérrez, Susana Contreras-Duarte, Luis Sobrevia, Andrea Leiva
Maternal physiological or supraphysiological hypercholesterolemia (MPH, MSPH) occurs during pregnancy. MSPH is associated with foetal endothelial dysfunction and atherosclerosis. However, the potential effects of MSPH on placental microvasculature are unknown. The aim of this study was to determine whether MSPH alters endothelial function in the placental microvasculature both ex vivo in venules and arterioles from the placental villi and in vitro in primary cultures of placental microvascular endothelial cells (hPMEC)...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768038/use-and-characteristics-of-antipsychotic-methylphenidate-combination-therapy-in-children-and-adolescents-with-a-diagnosis-of-attention-deficit-hyperactivity-disorder
#5
Oliver Scholle, Tobias Banaschewski, Dirk Enders, Edeltraut Garbe, Oliver Riedel
OBJECTIVE: Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) frequently have comorbidities that are potential indications for antipsychotics (APs). Some studies have suggested that the combined use of methylphenidate (MPH) and APs is increasing in this population group. Longitudinal analyses and in-depth investigations on the substance level are lacking. This study aimed to estimate the cumulative proportion of concomitant AP/MPH use in children and adolescents with ADHD over a follow-up of up to 9 years and to describe patient characteristics stratified by specific AP drug...
May 16, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29765401/mixed-effects-modeling-of-neurofeedback-self-regulation-performance-moderators-for-learning-in-children-with-adhd
#6
Agnieszka Zuberer, Franziska Minder, Daniel Brandeis, Renate Drechsler
Introduction: Neurofeedback (NF) has gained increasing popularity as a training method for children and adults with attention deficit hyperactivity disorder (ADHD). However, it is unclear to what extent children learn to regulate their brain activity and in what way NF learning may be affected by subject- and treatment-related factors. Methods: In total, 48 subjects with ADHD (age 8.5-16.5 years; 16 subjects on methylphenidate (MPH)) underwent 15 double training sessions of NF in either a clinical or a school setting...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29760243/underutilisation-of-public-access-defibrillation-is-related-to-retrieval-distance-and-time-dependent-availability
#7
Charles D Deakin, Steve Anfield, Gillian A Hodgetts
INTRODUCTION: Public access defibrillation doubles the chances of neurologically intact survival following out-of-hospital cardiac arrest (OHCA). Although there are increasing numbers of defibrillators (automated external defibrillator (AEDs)) available in the community, they are used infrequently, despite often being available. We aimed to match OHCAs with known AED locations in order to understand AED availability, the effects of reduced AED availability at night and the operational radius at which they can be effectively retrieved...
May 14, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29750737/inter-and-intraindividual-variation-of-methylphenidate-concentrations-in-serum-and-saliva-of-patients-with-attention-deficit-hyperactivity-disorder
#8
Joshua Preiskorn, Sophie Studer, Reinhold Rauh, Richard Lukačin, Christoph Geffert, Christian Fleischhaker, Hans-Willi Clement, Eberhard Schulz, Monica Biscaldi
BackgroundTherapeutic drug monitoring (TDM) is becoming increasingly important in psychiatric therapy; especially in children. However, for several reasons, it cannot yet be implemented as a daily routine in clinical or outpatient settings. To evaluate new, non-invasive procedures; blood and saliva (oral fluid) samples were collected from patients with attention-deficit/hyperactivity disorder (ADHD) who were also being administered methylphenidate (MPH). The study's main purposes were to correlate MPH concentrations in serum and saliva between subjects; and to analyze intraindividual variation of serum concentration...
May 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29750651/predictors-of-bone-maturation-growth-rate-and-adult-height-in-children-with-central-precocious-puberty-treated-with-depot-leuprolide-acetate
#9
Karen O Klein, Sanja Dragnic, Ahmed M Soliman, Peter Bacher
BACKGROUND: Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relationships between growth, rate of bone maturation (bone age/chronological age [ΔBA/ΔCA]), luteinizing hormone (LH), predicted adult stature (PAS), as well as variables influencing these outcomes, were studied in children treated with depot leuprolide (LA Depot) Methods: Subjects (64 girls, seven boys) with CPP received LA Depot every 3 months for up to 42 months...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29740695/metabolic-influence-of-walnut-phenolic-extract-on-mitochondria-in-a-colon-cancer-stem-cell-model
#10
Jina Choi, Phil-Kyung Shin, Yuri Kim, Chang Pyo Hong, Sang-Woon Choi
PURPOSE: Walnut phenolic extract (WPE) reduces proliferation and enhances differentiation of colon cancer stem cells (CSCs). The present study investigated the metabolic influence of WPE on the mitochondrial function of colon CSCs to determine its underlying mechanism. METHODS: CD133+ CD44+ HCT116 colon cancer cells were selected by fluorescence-activated cell sorting and were treated with or without 40 µg/mL WPE. RNA-sequencing (RNA-Seq) was performed to identify differentially expressed genes (DEGs), which were further validated with RT-PCR...
May 8, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29739137/methylphenidate-induced-lip-and-tongue-biting
#11
Cem Gokcen, Mehmet Karadag, Ihsan Aksoy
Attention deficit hyperactivity disorder (ADHD) is a life-long neurodevelopmental disorder and treatment depends on pharmacotherapy because of its biological origin. Stimulant drugs are the most commonly used treatment for ADHD and they have various side effects. Herein, we report a case who bit off the tip of her tongue with Osmotic Release Oral System methylphenidate (OROS MPH) 36 mg/day, bit the tip of her lower lip with immediate release (IR) MPH 10 mg/day and lateral part of her tongue with IR MPH 20 mg/day...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29738598/epidemiology-workload-and-performance-of-major-league-baseball-pitchers-placed-on-the-disabled-list
#12
Nathan E Marshall, Toufic R Jildeh, Kelechi R Okoroha, Ankur Patel, Vasilios Moutzouros, Eric C Makhni
There is limited information on the effect of pitcher workload, pitch type, and performance of Major League Baseball pitchers placed on the disabled list (DL). This study evaluated demographic, performance, workload, and injury data of 330 Major League Baseball pitchers with 454 injuries who were placed on the DL during the 2014 and 2015 seasons. Upper extremity, lower extremity, core, hip/groin, and other injuries were analyzed, and injury year data were compared with career data as well as against other injury groups...
May 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29733106/how-do-stimulant-treatments-for-adhd-work-evidence-for-mediation-by-improved-cognition
#13
Larry W Hawk, Whitney D Fosco, Craig R Colder, James G Waxmonsky, William E Pelham, Keri S Rosch
BACKGROUND: Stimulant medications such as methylphenidate (MPH) are the frontline treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). Despite their well-documented efficacy, the mechanisms by which stimulants improve clinical outcomes are not clear. The current study evaluated whether MPH effects on classroom behavior were mediated by improved cognitive functioning. METHODS: Children with ADHD (n = 82; 9-12 years old) participated in a week-long summer research camp, consisting of cognitive testing, classroom periods, and recreational activities...
May 7, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29708762/improvements-in-irritability-with-open-label-methylphenidate-treatment-in-youth-with-comorbid-attention-deficit-hyperactivity-disorder-and-disruptive-mood-dysregulation-disorder
#14
Drew E Winters, Sadaaki Fukui, Ellen Leibenluft, Leslie A Hulvershorn
OBJECTIVE: The purpose of this open-label study was to examine the effects of long-acting methylphenidate (MPH) treatment on irritability and related emotional symptoms associated with disruptive mood dysregulation disorder (DMDD) in youth with comorbid attention-deficit/hyperactivity disorder (ADHD). METHODS: The sample included 22 medication-free male and female subjects (ages 9-15) who met criteria for both DMDD and ADHD. Participants underwent a 4-week trial of long-acting MPH treatment (Concerta® ), with weekly dosing increases until a therapeutic dose was reached...
April 30, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29703430/relative-bioavailability-of-methylphenidate-extended-release-chewable-tablets-chewed-versus-swallowed-whole
#15
Richat Abbas, Ann C Childress, Praneeta Nagraj, Richard Rolke, Sally A Berry, Donna R Palumbo
PURPOSE: Methylphenidate hydrochloride extended-release chewable tablet (MPH ERCT) is approved for treatment of attention deficit hyperactivity disorder in patients aged 6 years and older. This article evaluates the pharmacokinetic parameters and relative bioavailability of MPH ERCT when chewed versus swallowed whole. METHODS: In this open-label, single-dose, 3-period, 3-treatment crossover study, 12 healthy adult volunteers were randomly assigned to treatment sequence...
April 24, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29700135/draft-genome-sequence-of-multidrug-resistant-escherichia-coli-nivedi-p44-isolated-from-a-chicken-fecal-sample-in-northeast-india
#16
Rituparna Tewari, Susweta Das Mitra, Sangita Das, Sudhir Jadhao, Gayatri Mishra, Feroze Ganaie, Rajeswari Shome, Habibur Rahman, Bibek Ranjan Shome
We report here the draft genome sequence of a multidrug-resistant Escherichia coli strain (NIVEDI-P44) isolated from a chicken fecal sample. The estimated genome size is 4.76 Mb, with a G+C content of 50.65%. The genome harbors multiple antibiotic resistance genes, bla DHA-1 , mph (A), strA , strB , dfrA14 , sul-2 , tet (A), and qnrS1 .
April 26, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29694272/effect-of-mouthguard-use-on-metabolic-and-cardiorespiratory-responses-to-aerobic-exercise-in-males
#17
Michael S Green, Amanda K Benson, Tyler D Martin
PURPOSE: This study investigated the physiological effects of wearing a mouthguard during submaximal treadmill exercise. METHOD: Twenty-four recreationally active males (Mage = 21.3 ± 2.4 years, Mheight = 1.78 ± 0.06 m, Mweight = 81.9 ± 10.6 kg, Mbody mass index = 25.8 ± 3.4 kg·m-2 ) performed incremental, continuous exercise at 2, 4, 6, and 8 mph (3.2, 6.4, 9.7, 12.9 kph) for 5 min at each speed on a motor-driven treadmill on 2 separate occasions in a randomized, crossover, counterbalanced design while wearing or not wearing a self-adaptable "boil and bite" mouthguard...
April 25, 2018: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29691605/social-reinforcement-as-alternative-to-sucrose-reinforcement-is-increased-by-nicotine-and-methylphenidate-in-male-fischer-344-rats
#18
Connor D Martin, Heather M Bool, Anthony M George, Katelyn A Carr, Leonard H Epstein, Larry W Hawk, Jerry B Richards
BACKGROUND: Stimulant drugs such as nicotine (NIC) and methylphenidate (MPH) are hypothesized to increase the reinforcing value of sensory stimuli, thus increasing the effectiveness of such reinforcers as alternatives to sucrose reinforcers. METHODS: Inbred Fischer-344 rats (n = 30) were assigned to three groups: saline (SAL; n = 10), nicotine (NIC; n = 10), or methylphenidate (MPH; n = 10). Testing was done in three phases: sucrose only, (SUC), sucrose and drug (SUC/DRUG), and sucrose, drug, and social reinforcement (SUC/DRUG/SOC)...
April 24, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29689540/investigational-antiretroviral-drugs-what-is-coming-down-the-pipeline
#19
Roy M Gulick
Over the past 30 years, antiretroviral drug regimens for treating HIV infection have become more effective, safer, and more convenient. Despite 31 currently approved drugs, the pipeline of investigational HIV drugs remains full. Investigational antiretroviral drugs include the nucleoside analogue reverse transcriptase translocation inhibitor (NRTTI) MK-8591, a long-acting compound that could be dosed once weekly. Investigational nonnucleoside analogue reverse transcriptase inhibitors (NNRTIs) include doravirine, which is active in vitro against NNRTI-resistant HIV and was potent and well-tolerated when used in combination with a dual-nucleoside analogue RTI (nRTI) backbone in treatment-naive individuals...
April 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29684537/genetic-imaging-study-with-tc-99m-trodat-1-spect-in-adolescents-with-adhd-using-oros-methylphenidate
#20
Aynur Pekcanlar Akay, Gamze Çapa Kaya, Samet Kose, Çiğdem Eresen Yazıcıoğlu, Handan Özek Erkuran, Sevay Alşen Güney, Kaya Oğuz, Duygu Keskin, Burak Baykara, Neslihan İnal Emiroğlu, Mine Şencan Eren, Sefa Kızıldağ, Türkan Ertay, Dua Özsoylu, Süha Miral, Hatice Durak, Ali Saffet Gönül, Luis Augusto Rohde
AIM: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-99m ] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability. METHODS: Twenty adolescents with ADHD underwent brain single-photon emission computed tomography (SPECT) scans with [Tc-99m ] TRODAT-1 at baseline and two months after starting OROS-MPH treatment with dosages up to 1 mg/kg/day...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
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