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https://www.readbyqxmd.com/read/28436738/brainstem-injury-in-motor-vehicle-crashes
#1
David C Viano, Chantal S Parenteau
OBJECTIVE: This is a descriptive study of the frequency and risk for brainstem injury by crash type, belt use and crash severity (delta V). NASS-CDS electronic cases were reviewed to see if the transition from vehicles without advanced airbags and seatbelts, side airbags and curtains to vehicles with the safety technologies has influenced the risk for brainstem injury. METHODS: 1994-2013 NASS-CDS was analyzed to determine the number of brainstem injuries in non-ejected adults (15+ year old) in vehicle crashes...
March 1, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28422635/simulated-driving-skills-evaluation-of-teenagers-with-attention-deficit-hyperactivity-disorder-before-driving-lessons
#2
Navah Zelda Ratzon, Efrat Kadury Lunievsky, Arie Ashkenasi, Joseph Laks, Herman Avner Cohen
OBJECTIVE: We evaluated the driving skills of teenagers with attention deficit hyperactivity disorder (ADHD) during simulated driving before starting driving lessons and observed whether methylphenidate (MPH) affected their performance. METHOD: Sixty teenagers ages 15-18 yr were included; 29 teenagers with ADHD were tested with and without MPH, and 31 teenagers (control group) were tested once. All participants were tested on the STISIM Drive™ simulator. RESULTS: The number of center-line crossings was higher in the group without MPH treatment than in the control group and the MPH-treated group...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28416110/structural-basis-for-kinase-mediated-macrolide-antibiotic-resistance
#3
Desiree H Fong, David L Burk, Jonathan Blanchet, Amy Y Yan, Albert M Berghuis
The macrolides are a class of antibiotic, characterized by a large macrocyclic lactone ring that can be inactivated by macrolide phosphotransferase enzymes. We present structures for MPH(2')-I and MPH(2')-II in the apo state, and in complex with GTP analogs and six different macrolides. These represent the first structures from the two main classes of macrolide phosphotransferases. The structures show that the enzymes are related to the aminoglycoside phosphotransferases, but are distinguished from them by the presence of a large interdomain linker that contributes to an expanded antibiotic binding pocket...
April 1, 2017: Structure
https://www.readbyqxmd.com/read/28412445/methylphenidate-effects-in-the-young-brain-friend-or-foe
#4
REVIEW
Sara Loureiro-Vieira, Vera Marisa Costa, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Soares Capela
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and methylphenidate (MPH) is a first-line stimulant drug available worldwide for its treatment. Despite the proven therapeutic efficacy, concerns have been raised regarding the possible consequences of chronic MPH exposure during childhood and adolescence. Disturbances in the neurodevelopment at these crucial stages are major concerns given the unknown future life consequences...
April 12, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28410830/patient-first-wer-ist-der-patient-und-wie-wird-er-in-der-gesundheitsversorgung-beteiligt
#5
EDITORIAL
Thomas Petzold, Maria Eberlein-Gonska, Jochen Schmitt Mph
No abstract text is available yet for this article.
April 11, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28398816/the-possible-effect-of-methylphenidate-treatment-on-empathy-in-children-diagnosed-with-attention-deficit-hyperactivity-disorder-both-with-and-without-comorbid-oppositional-defiant-disorder
#6
Pavel Golubchik, Abraham Weizman
OBJECTIVE: To assess the Empathizing Quotient (EQ) of patients diagnosed with attention-deficit/hyperactivity disorder (ADHD) only or comorbid with oppositional defiant disorder (ODD) and compare the two groups' responses to methylphenidate (MPH) treatment. METHODS: Fifty-two children (8-18 years) diagnosed with ADHD, 26 of whom were also diagnosed with comorbid ODD (ADHD/ODD), were treated with MPH for 12 weeks. The level of EQ was assessed with the Children's version of the Empathizing Quotient (EQ-C) and the severity of ADHD symptoms with the ADHD Rating Scale (ADHD-RS)...
February 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28391507/interaction-of-chronic-food-restriction-and-methylphenidate-in-sensation-seeking-of-rats
#7
Aleksandr D Talishinsky, Celine Nicolas, Satoshi Ikemoto
RATIONALE: It is necessary to understand better how chronic food restriction (CFR) and psychostimulant drugs interact in motivated behavior unrelated to food or energy homeostasis. OBJECTIVES: We examined whether CFR augments methylphenidate (MPH)-potentiated responding reinforced by visual sensation (VS) and whether repeated MPH injections or prolonged CFR further augments such responses. METHODS: Before starting the following experiments, rats on a CFR diet received a limited daily ration in such a way that their body weights decreased to 85-90% of their original weights over 2 weeks...
April 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28388850/auditory-and-visual-executive-functions-in-children-and-response-to-methylphenidate-a-randomized-controlled-trial
#8
Yaffa Hadar, Shraga Hocherman, Oren Lamm, Emanuel Tirosh
OBJECTIVES: The aim of the study was to assess auditory and visually based executive functions (EFs) and the effect of methylphenidate (MPH) in children with ADHD. METHODS: Thirty-six boys between the ages of 8.3 and 9.7 years with ADHD and 36 matched controls were included. The study group was randomized into MPH and placebo for 7 days each in a crossover design. A Cued Choice Reaction Time (CCRT) test that included incongruent cuing was administered at baseline and following 1 and 2 weeks...
April 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28388318/rotary-and-high-pressure-nozzle-spray-plume-droplet-analysis-for-aerially-applied-mosquito-adulticides-laser-diffraction-characterization
#9
Jonathan A Hornby, Jim Robinson, Milton Sterling
The droplet spectrum of a mosquito adulticide spray plume determines its ability to drift through the target area, impinge on the mosquito, deliver a toxic dose, and the risk of environmental contamination. This paper provides data on droplet spectra produced from 6 nozzles in a high-pressure nozzle spray system and 5 rotary nozzle systems for common mosquito adulticides. Spray plume spectra were measured by laser diffraction. High-pressure nozzles were evaluated at pressures ranging from 500 psi to 6,000 psi...
March 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28379986/relevance-popularity-a-term-event-model-based-feature-selection-scheme-for-text-classification
#10
Guozhong Feng, Baiguo An, Fengqin Yang, Han Wang, Libiao Zhang
Feature selection is a practical approach for improving the performance of text classification methods by optimizing the feature subsets input to classifiers. In traditional feature selection methods such as information gain and chi-square, the number of documents that contain a particular term (i.e. the document frequency) is often used. However, the frequency of a given term appearing in each document has not been fully investigated, even though it is a promising feature to produce accurate classifications...
2017: PloS One
https://www.readbyqxmd.com/read/28378561/comparison-of-objective-and-subjective-changes-induced-by-multiple-pinhole-glasses-and-single-pinhole-glasses
#11
Won Soo Kim, In Ki Park, Young Kee Park, Yeoun Sook Chun
Multiple-pinhole (MPH) glasses are currently sold in many countries with unproven advertisements; however, their objective and subjective effects have not been investigated. Therefore, to investigate the effects of MPH glasses excluding the single-pinhole (SPH) effect, we compared the visual functional changes, reading speed, and ocular discomfort after reading caused by MPH and SPH glasses. Healthy 36 participants with a mean age of 33.1 years underwent examinations of pupil size, visual acuity (VA), depth of focus (DOF), and near point accommodation (NPA); tests for visual field (VF), contrast sensitivity (CS), stereopsis, and reading speed; and a survey of ocular discomfort after reading...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28376888/daily-administration-of-yokukansan-and-keishito-prevents-social-isolation-induced-behavioral-abnormalities-and-down-regulation-of-phosphorylation-of-neuroplasticity-related-signaling-molecules-in-mice
#12
Hironori Fujiwara, Yaoyu Han, Ken Ebihara, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
BACKGROUND: Our previous studies demonstrated that post-weaning social isolation (ISO) in mice induces behavior abnormalities such as deficits of sociability- and attention-like behaviors. These deficits can be attenuated by methylphenidate (MPH), a drug used for attention deficit hyperactivity disorder (ADHD), suggesting that ISO mice offer a potential animal model of comorbid developmental disorder with ADHD and autism spectrum disorder symptoms. This study investigated the effects of Kampo formulae, yokukansan (YKS) and keishito (KST), on the neuropsychiatric symptoms of ISO mice to clarify the therapeutic or preventive/delaying potential of these formulae for the treatment of neurodevelopmental disorders...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28376677/lens-opacities-in-children-using-methylphenidate-hydrochloride
#13
Nagihan Saday Duman, Rahmi Duman, Emel Sarı Gökten, Reşat Duman
PURPOSE: To assess clinical findings of eye examination in children who is taking methylphenidate hydrochloride with Attention Deficit Hyperactivity Disorder. METHODS: Fifty seven consecutive patients who were diagnosed of Attention Deficit Hyperactivity Disorder (ADHD) and have been under oral methylphenidate hydrochloride treatment for at least one year were involved in this study (Group 1). Sixty healthy subjects (Group 2) who have similar demographic features compared with the group 1, were involved as a control group...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376469/sean-lucan-md-mph-ms-selected-as-2016-nam-puffer-abfm-fellow
#14
Jane Ireland
No abstract text is available yet for this article.
January 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28373192/a-waterborne-outbreak-of-shigella-sonnei-with-resistance-to-azithromycin-and-third-generation-cephalosporins-in-china-2015
#15
Qiuxia Ma, Ming Luo, Xuebin Xu, Jian Wang, Chaojie Yang, Xiaofeng Hu, Beibei Liang, Fuli Wu, Xiaoxia Yang, Jinyan Wang, Hongbo Liu, Wen Li, Yu Zhong, Peng Li, Jing Xie, Leili Jia, Ligui Wang, Rongzhang Hao, Xinying Du, Shaofu Qiu, Hongbin Song, Yansong Sun
Here we for the first time reported a waterborne outbreak of Shigella sonnei in China, 2015. Eleven multidrug resistance (MDR) S. sonnei isolates were recovered, showing highly resistant to azithromycin and third-generation cephalosporins particularly, due to the mph (A) and blaCTX-M-14-encoding IncB/O/K/Z group transmissible plasmid of 104.285 kb in size. Our study highlights the potential prevalence of the MDR outbreak S. sonnei in China and its further dissemination worldwide with the development of globalization...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28371725/age-related-pharmacotherapy-of-attention-deficit-hyperactivity-disorder-in-slovenia-in-children-and-adolescents-a-population-based-study
#16
M Stuhec, I Locatelli
BACKGROUND: There are no data on age-related pharmacotherapy for Attention Deficit Hyperactivity Disorder (ADHD) medication in children and adolescents in the most European countries. The main aim of this paper was to obtain that data for children and adolescents in Slovenia. METHOD: The number of ADHD drug prescriptions per patient was obtained from the health claims data on prescription drugs of the Health Insurance Institute of Slovenia for the study period (2003-2015)...
May 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28369788/model-based-approach-for-optimizing-study-design-and-clinical-drug-performances-of-extended-release-formulations-of-methylphenidate-for-the-treatment-of-adhd
#17
R Gomeni, Fmm Bressolle-Gomeni, T J Spencer, S V Faraone, L Fang, A Babiskin
Methylphenidate (MPH) is currently used to treat children with attention deficit hyperactivity disorder (ADHD). Several extended-release (ER) formulations characterized by a dual release process were developed to improve efficacy over an extended duration. In this study, a model-based approach using literature data was developed to: a) evaluate the most efficient pharmacokinetic (PK) model to characterize the complex PK profile of MPH ER formulations; b) provide PK endpoint metrics for comparing ER formulations; c) define criteria for optimizing development of ER formulations using a convolution-based model linking in-vitro release, in-vivo release and hour-by-hour behavioral ratings of ADHD symptoms; and d) define an optimized trial design for assessing the activity of MPH in pediatric populations...
March 29, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28368900/the-effect-of-methylphenidate-on-anxiety-and-depression-symptoms-in-patients-with-asperger-syndrome-and-comorbid-attention-deficit-hyperactivity-disorder
#18
Pavel Golubchik, Michal Rapaport, Abraham Weizman
The objective of this study was to assess the response of anxiety and depression symptoms to methylphenidate (MPH) treatment in patients with Asperger syndrome (AS) combined with attention deficit/hyperactivity disorder (ADHD). A group of 12 patients with AS/ADHD, aged 8-18 years, received 12 weeks of MPH treatment. The severities of ADHD, anxiety, and depression symptoms were assessed by means of the ADHD Rating Scale (ADHD-RS), Screen for Child Anxiety Related Emotional Disorders, and the Children's Depression Inventory...
March 31, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28367712/the-clinical-characteristics-of-adhd-diagnosed-in-adolescents-in-comparison-with-younger-children
#19
Muhammad Mahajnah, Rajech Sharkia, Nadeem Shorbaji, Nathanel Zelnik
OBJECTIVE: The aim of this study is to identify the clinical characteristics in adolescents newly diagnosed with ADHD. METHOD: Data of patients aged 7 to 17 years diagnosed with ADHD were collected and analyzed. The patients were divided into adolescents aged 13 to 17 years (Group I) and children aged 7 to 12 years (Group II): 592 males and 231 females. Group I consists of 450 participants, and Group II consists of 373 participants. RESULTS: Adolescents were predominantly inattentive (63...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28364286/adult-height-after-spontaneous-pubertal-growth-or-gnrh-analog-treatment-in-girls-with-early-puberty-a-meta-analysis
#20
Silvano Bertelloni, Francesco Massart, Mario Miccoli, Giampiero I Baroncelli
Early puberty (EP) has been defined as the onset of puberty in the low-normal range; it may be a cause for concern regarding a possible impairment of adult height (AH). This paper meta-analysed data on AH after spontaneous growth or after gonadotropin-releasing hormone (GnRH) analog treatment in girls with EP. A computerized literature search was conducted from 1980 to June 30, 2016. Only published studies in English were considered. Eight papers were selected (483 cases). In untreated girls (n = 300), predicted adult height (PAH) at start of follow-up (-0...
April 1, 2017: European Journal of Pediatrics
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