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https://www.readbyqxmd.com/read/29322883/cardiac-mesothelial-papillary-hyperplasia-in-four-dogs
#1
Shannon G Kirejczyk, Anne L Burnum, Corrie C Brown, Kaori Sakamoto, Daniel R Rissi
Mesothelial papillary hyperplasia (MPH) has been described as an incidental finding on the epicardial surface of clinically normal laboratory Beagle dogs. We describe MPH in 4 dogs diagnosed with acute cardiac tamponade (1 case) or chronic cardiac disease (3 cases). Cardiac MPH appeared as distinct, soft, irregular villous plaques on the epicardial surface of the auricles and occasionally the ventricles. Histologically, areas of MPH were composed of multiple papillary fronds arising from the epicardial surface and projecting into the pericardial space...
January 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29322371/relationship-of-parental-genetic-distance-with-heterosis-and-specific-combining-ability-in-sesame-sesamum-indicum-l-based-on-phenotypic-and-molecular-marker-analysis
#2
Sarita K Pandey, Tapash Dasgupta, Abhishek Rathore, Anilkumar Vemula
The genetic distance analysis for selection of suitable parents has been established and effectively used in many crops; however, there is dearth of conclusive report of relationship of genetic distance analysis with heterosis in sesame. In the present study, an attempt was made to estimate the associations of genetic distances using SSR (GDSSR), seed-storage protein profiling (GDSDS) and agro-morphological traits (GDMOR) with hybrid performance. Seven parents were selected from 60 exotic and Indian genotypes based on genetic distance from clustering pattern based on SSR, seed-storage protein, morphological traits and per se performance...
January 10, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29317696/unraveling-individual-differences-in-the-hiv-1-transgenic-rat-therapeutic-efficacy-of-methylphenidate
#3
Kristen A McLaurin, Hailong Li, Rosemarie M Booze, Amanda J Fairchild, Charles F Mactutus
Despite the heterogeneity of HIV-1 associated neurocognitive disorders (HAND), assignment of categorical diagnoses based on the level of impairment (e.g., Frascati criteria) obfuscates the well-acknowledged variability observed within the population of HIV-1+ individuals. The present study sought to elucidate the natural heterogeneity in adult HIV-1 transgenic (Tg) rats using three interrelated aims. First, heterogeneity of the HIV-1 transgene was examined using a pretest-posttest design to assess therapeutic efficacy of oral self-administration (OSA) of methylphenidate (MPH; 2...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317655/the-evolution-of-substrate-discrimination-in-macrolide-antibiotic-resistance-enzymes
#4
Andrew C Pawlowski, Peter J Stogios, Kalinka Koteva, Tatiana Skarina, Elena Evdokimova, Alexei Savchenko, Gerard D Wright
The production of antibiotics by microbes in the environment and their use in medicine and agriculture select for existing and emerging resistance. To address this inevitability, prudent development of antibiotic drugs requires careful consideration of resistance evolution. Here, we identify the molecular basis for expanded substrate specificity in MphI, a macrolide kinase (Mph) that does not confer resistance to erythromycin, in contrast to other known Mphs. Using a combination of phylogenetics, drug-resistance phenotypes, and in vitro enzyme assays, we find that MphI and MphK phosphorylate erythromycin poorly resulting in an antibiotic-sensitive phenotype...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29309529/current-issues-in-the-impacts-of-transport-on-health
#5
M C I van Schalkwyk, J S Mindell
Introduction or background: Transport affects health in many ways. Benefits include access to education, employment, goods, services and leisure, and opportunities for incorporating physical activity into daily living. There are major inequalities: benefits generally accrue to wealthier people and harms to the more deprived, nationally and globally. Sources of data: Health on the Move 2; Journal of Transport and Health. Areas of agreement: Benefits of travel for access and physical activity...
January 4, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29288365/methylphenidate-disrupts-cytoskeletal-homeostasis-and-reduces-membrane-associated-lipid-content-in-juvenile-rat-hippocampus
#6
Felipe Schmitz, Paula Pierozan, Helena Biasibetti-Brendler, Fernanda Silva Ferreira, Fernanda Dos Santos Petry, Vera Maria Treis Trindade, Regina Pessoa-Pureur, Angela T S Wyse
Although methylphenidate (MPH) is ubiquitously prescribed to children and adolescents, the consequences of chronic utilization of this psychostimulant are poorly understood. In this study, we investigated the effects of MPH on cytoskeletal homeostasis and lipid content in rat hippocampus. Wistar rats received intraperitoneal injections of MPH (2.0 mg/kg) or saline solution (controls), once a day, from the 15th to the 44th day of age. Results showed that MPH provoked hypophosphorylation of glial fibrillary acidic protein (GFAP) and reduced its immunocontent...
December 29, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29287299/-laudation-at-the-presentation-of-the-salomon-neumann-medal-2017-to-prof-dr-med-med-bernt-peter-robra-mph
#7
Heiner Raspe
The German Society for Social Medicine and Prevention (DGSMP) confers the Salomon Neumann Medal for outstanding merit in the field of Preventive and Social Medicine. The Salomon Neumann Medal 2017 was awarded to Bernt-Peter Robra, Institute for Social Medicine and Health Economics (ISMG) of the Otto von Guericke University Magdeburg. It honours an outstanding representative of social medicine, in whose person and Institute the essential problem areas of social medicine as well as the competencies of the 3 scientific bodies that gathered in Lübeck - epidemiology, medical sociology and social medicine - and the sociopolitical engagement of Salomon Neumann come together...
December 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29251537/public-health-and-law-enforcement-joint-investigation-of-unknown-suspicious-substances-and-potential-threat-evaluations-minnesota-2007-2016
#8
Tory V Whitten, Maureen M Sullivan, Stefan Saravia, Jayne Griffith, Joni M Scheftel, Richard N Danila
From the Field is a semi-regular column that explores what it means to be a local health professional on the front lines of an emergency. Typically, National Association of County and City Health Officials (NACCHO) members share their stories of preparing for and responding to disasters, epidemics, and other major health issues. This month's column features a submission from a state health department that describes their experience in investigating white powder incidents. Through exploring the analysis of the challenges faced and the solutions developed, readers can learn how these public health champions keep their communities safe even in extreme situations...
November 2017: Health Security
https://www.readbyqxmd.com/read/29250044/clonal-diversity-virulence-potential-and-antimicrobial-resistance-of-escherichia-coli-causing-community-acquired-urinary-tract-infection-in-switzerland
#9
Magdalena T Nüesch-Inderbinen, Melinda Baschera, Katrin Zurfluh, Herbert Hächler, Hansjakob Nüesch, Roger Stephan
Objectives: The aim of this study was to assess the clonal structure, virulence potential and antibiotic susceptibility of uropathogenic Escherichia coli (UPEC) isolates causing community acquired urinary tract infection (CAUTI) in unselected primary care patients in Switzerland. Methods: We performed multilocus sequence typing, virulence factor determination, and phenotypic and genotypic antimicrobial resistance testing on 44 non-duplicate UPEC isolates. Results: Twenty-seven different sequence types (STs) were identified...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29249700/introduction
#10
Mary Politi, Emily S Jungheim
This symposium includes twelve personal, heartfelt narratives about joys, challenges, and, in some cases, trauma associated with labor and delivery experiences. This issue also includes three commentaries on these narratives by 1.) Raymond De Vries, PhD, 2.) Anne Lyerly, MD, MA, 3.) Jason Wasserman, PhD and Nicole Wasserman, MPH. This issue can provide information for clinicians and support staff on ways to facilitate patient and family engagement during this emotionally-laden time for parents. Supporting birth experiences, connecting with patients, involving them in decisions, and recognizing the disappointment and distress that can arise when complications abound may play a part in reducing postpartum mood disorders and improving maternal and infant health outcomes...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29244542/differential-long-term-medication-impact-on-executive-function-and-delay-aversion-in-adhd
#11
Belen Rubio Morell, Sergio Hernández Expósito
The objective was to compare long-term effects of methylphenidate (MPH) and atomoxetine (ATX) on executive functions (EF) and delay aversion (DAv) in ADHD. A randomized controlled trial was conducted. A comprehensive neuropsychological battery was administered at three moments (Naive, Post-1, Post-2). ADHD participants who showed deficits in the naive evaluation (n = 26) were randomized to receive either MPH (n = 13; Mage = 11 ± 1, MIQ 96 ± 8) or ATX (n = 13; Mage = 10 ± 1, MIQ 106 ± 16...
December 15, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29225021/implications-of-core-and-hip-injuries-on-major-league-baseball-pitchers-on-the-disabled-list
#12
Nathan E Marshall, Toufic R Jildeh, Kelechi R Okoroha, Ankur Patel, Vasilios Moutzouros, Eric C Makhni
PURPOSE: To investigate the frequency of core and hip injuries in Major League Baseball (MLB) pitchers and their impact on performance, workload, and pitch type. METHODS: Demographic, performance data, and injury data were acquired for 330 MLB pitchers with 454 injuries placed on the disabled list (DL) from 2014 to 2015 seasons. Core and hip/groin injuries were analyzed in which injury year data were compared with career data and against other injury groups. RESULTS: Core injuries represented 14% of all injuries and hip/groin injuries represented 7%...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29223026/mandatory-helmet-legislation-as-a-policy-tool-for-reducing-motorcycle-fatalities-pinpointing-the-efficacy-of-universal-helmet-laws
#13
Jonathan M Lee
This study uses repeated cross-sections of individual level crash data to study the effectiveness of motorcycle helmet legislation. Results suggest that motorcycle helmet laws reduce average individual fatality risks by 20.5%. From a policy standpoint, large states such as Florida and Texas can reduce annual motorcycle fatalities by an average 100 deaths through reinstating universal helmet laws. Valuing these fatality reductions at the U.S. DOT suggested $9.4 million value of a statistical life yields aggregate annual state benefits of approximately $940 million...
December 6, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29216434/yale-integrative-medicine-leader-ather-ali-nd-mph-mhs-1975-2017
#14
John Weeks
No abstract text is available yet for this article.
December 7, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29206921/acute-effects-of-methylphenidate-modafinil-and-mdma-on-negative-emotion-processing
#15
André Schmidt, Felix Müller, Patrick C Dolder, Yasmin Schmid, Davide Zanchi, Laura Egloff, Matthias E Liechti, Stefan Borgwardt
Background: Stimulants such as methylphenidate (MPH) and modafinil are frequently used as cognitive enhancers in healthy people, whereas 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is proposed to enhance mood and empathy in healthy subjects. However, comparative data on the effects of MPH and modafinil on negative emotions in healthy subjects have been widely missing. The aim of this study was to compare the acute effects of MPH and modafinil on the neural correlates of fearful face processing using MDMA as a positive control...
December 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29205089/altered-bioenergetic-profile-in-umbilical-cord-and-amniotic-mesenchymal-stem-cells-from-newborns-of-obese-women
#16
Laura Iaffaldano, Carmela Nardelli, Francesca D'Alessio, Valeria D'Argenio, Marcella Nunziato, Lucia Mauriello, Claudio Procaccini, Giuseppe Maria Maruotti, Pasquale Martinelli, Giuseppe Matarese, Lucio Pastore, Luigi Del Vecchio, Giuseppe Labruna, Lucia Sacchetti
Nutritional imbalance and metabolic alterations associated with maternal obesity during pregnancy predispose offspring to obesity and/or to type 2 diabetes, but the mechanisms underlying these effects are still obscure. In this context, we evaluated whether the two main energy-producing pathways (glycolysis and mitochondrial oxidative phosphorylation) are impaired in obesity during pregnancy thus contributing to metabolic intrauterine alterations. Specifically, we studied metabolic abnormalities in the intrauterine life of newborns using stem cells isolated from amnion and umbilical cord (hA- and hUC-MSCs)...
January 3, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29203337/shati-nat8l-knockout-mice-show-behavioral-deficits-ameliorated-by-atomoxetine-and-methylphenidate
#17
Kazuya Toriumi, Junko Tanaka, Takayoshi Mamiya, Tursun Alkam, Hyoung-Chun Kim, Atsumi Nitta, Toshitaka Nabeshima
We previously identified a novel molecule, SHATI/NAT8L, as having an inhibitory effect on methamphetamine dependence. We generated Shati/Nat8l knockout (KO) mice and found that they showed neurochemical changes and behavioral abnormalities related to attention deficit/hyperactivity disorder (AD/HD). In this study, we assessed validities of the Shati/Nat8l KO mice as a new animal model for AD/HD through a behavioral pharmacology approach. We conducted a locomotor activity test in a novel environment, a cliff avoidance test, and an object-based attention assay using Shati/Nat8l KO mice at the ages of 4 and 8 weeks...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29199476/sexual-violence-victimization-among-youth-presenting-to-an-urban-emergency-department-the-role-of-violence-exposure-in-predicting-risk
#18
Andria B Eisman, Quyen M Ngo, Yasamin Y Kusunoki, Erin E Bonar, Marc A Zimmerman PhD, Rebecca M Cunningham Md, Maureen A Walton PhD Mph
Sexual violence (SV) is a widespread public health problem among adolescents and emerging adults with significant short- and long-term consequences. Young people living in urban, disadvantaged communities with high rates of violence may be especially at risk for SV victimization. Understanding interconnections between different forms of violence is critical to reducing SV risk among youth. Participants were youth ( N = 599) ages 14 to 24 years ( M = 20.05, SD = 2.42) presenting to an urban emergency department with a Level 1 trauma designation as part of a prospective cohort study and followed-up for 24 months...
December 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29192941/-response-with-methylphenidate-to-adhd-like-symptoms-in-pervasive-developmental-disorder-does-ces-1-enzyme-gene-polymorphism-have-a-role
#19
Ülkü Akyol Ardıç, Eyüp Sabri Ercan, Duygu Aygüneş, Deniz Yüce, Sibel Durak, Buket Kosova
OBJECTIVE: Methylphenidate is the first-choice medication for the Pervasive Developmental Disorders (PDDs), and comorbid Attention Deficit Hyperactivity Disorder (ADHD). But this approach generally results with poor outcomes, and increased adverse effects. It is aimed to investigate the comparison of cases who diagnosed with PDDs and Mild Mental Retardation (MR) and cases with pure ADHD in terms of the clinical response to MPH. Also we aimed to investigate the relations between CES-1 polymorphism gene and the clinical response to MPH...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29186993/medication-use-in-adults-with-attention-deficit-hyperactivity-disorder-in-a-commercially-insured-population-in-the-united-states
#20
Zhou Zhou, Zheng-Yi Zhou, Sneha S Kelkar, Vanja Sikirica, Jipan Xie, Regina Grebla
OBJECTIVE: To examine real-world prescription medication usage among commercially-insured adults with attention deficit/hyperactivity disorder (ADHD) in the US. METHODS: Adults with ADHD who received ≥1 ADHD medication during 2013 were identified from a large US claims database. Combination therapy was defined as an overlap of ≥30 days between the index (first treatment ≥30 days in 2013) and another medication(s). Patients were classified into six groups: long-acting (LA) monotherapy, short-acting (SA) monotherapy, LA + LA, SA + SA, LA + SA, and >2 therapies...
December 8, 2017: Current Medical Research and Opinion
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