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https://www.readbyqxmd.com/read/28720182/ground-reaction-forces-during-reduced-gravity-running-in-parabolic-flight
#1
Peter Cavanagh, Andrea Rice, Molly Glauberman, Amanda Sudduth, Arien Cherones, Shane Davis, Michael Lewis, Andrea Hanson, Grier Wilt
BACKGROUND: Treadmills have been employed as both a form of exercise and a countermeasure to prevent changes in the musculoskeletal system on almost all NASA missions and many Russian missions since the early Space Shuttle flights. It is possible that treadmills may also be part of exercise programs on future Mars missions and that they may be a component of exercise facilities in lunar or Martian habitats. METHODS: In order to determine if the ambient gravity on these destinations will provide osteogenic effects while performing exercise on a treadmill, ground reactions forces (GRFs) were measured on eight subjects (six women and two men) running at 6 mph during parabolic flight in Martian and lunar gravity conditions...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28710268/physiological-evidence-for-isopotential-tunneling-in-the-electron-transport-chain-of-methane-producing-archaea
#2
Nikolas Duszenko, Nicole R Buan
Many, but not all, organisms use quinones to conserve energy in their electron transport chains. Fermentative bacteria and methane-producing archaea (methanogens) do not produce quinones but have devised other ways to generate ATP. Methanophenazine (MPh) is a unique membrane electron carrier found in Methanosarcina species that plays the same role as quinones in the electron transport chain. To extend the analogy between quinones and MPh, we compared the MPh pool sizes between two well-studied Methanosarcina species, Methanosarcina acetivorans C2A and Methanosarcina barkeri Fusaro to the quinone pools sizes in the bacterium, Escherichia coli We found the quantity of MPh per cell increases as cultures transition from exponential growth to stationary phase, and absolute quantities of MPh were 3-fold higher in M...
July 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28696773/rail-height-effects-on-safety-performance-of-midwest-guardrail-system
#3
Mojdeh Asadollahi Pajouh, Ramen D Julin, Cody S Stolle, John D Reid, Ronald K Faller
OBJECTIVE: Guardrail heights play a crucial role in the way that errant vehicles interact with roadside barriers. Low rail heights increase the propensity of vehicle rollover and override, while excessively-tall rails promote underride. Further, rail mounting heights and post embedment depths may be altered by variations in roadside terrain. An increased guardrail height may be desirable to accommodate construction tolerances, soil erosion, frost heave, and future roadway overlays. This study aimed to investigate and identify a maximum safe installation height for the Midwest Guardrail System, which would be robust and remain crashworthy before and after pavement overlays...
July 11, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28690991/effect-of-growth-hormone-treatment-on-children-with-idiopathic-short-stature-and-idiopathic-growth-hormone-deficiency
#4
Minji Im, Yong-Dae Kim, Heon-Seok Han
PURPOSE: There are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment in Korean children with idiopathic short stature (ISS) and idiopathic growth hormone deficiency (IGHD). Thus, the authors retrospectively compared the effects of GH in ISS and IGHD. METHODS: From the medical records of 26 ISS and 30 IGHD children, auxological and biochemical changes including chronologic age (CA), bone age (BA), height standard deviation score (HT-SDS), predicted adult height (PAH), midparental height (MPH), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-3) were compared...
June 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28690202/the-impact-of-methylphenidate-and-its-enantiomers-on-dopamine-synthesis-and-metabolism-in-vitro
#5
Jasmin Bartl, Ferruccio Palazzesi, Michele Parrinello, Leif Hommers, Peter Riederer, Susanne Walitza, Edna Grünblatt
Methylphenidate (MPH), a psychostimulant, is an effective first-line treatment for the symptoms associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Although most MPH formulations are composed of the racemic 1:1 mixture of the two enantiomers (d- and l-threo), converging lines of evidence indicate that d-threo MPH seems to be superior to the l-isomer. We aimed to investigate whether MPH racemic mixture or pure enantiomers influence the enzyme activity of tyrosine hydroxylase (TH), monoamine oxidase B (MAO-B), catechol-O-methyltransferase (COMT), and aldehyde dehydrogenase (ALDH) in vitro in homogenates of rat PC12 cells incubated with racemic, d- and l-threo MPH (1nM up to 100μM), or a vehicle for control...
July 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28689921/the-novel-mef-c-mph-g-macrolide-resistance-genes-are-conveyed-in-the-environment-on-various-vectors
#6
Yuta Sugimoto, Satoru Suzuki, Lisa Nonaka, Chanchai Boonla, Nop Sukpanyatham, Hsin-Yiu Chou, Jer-Horng Wu
BACKGROUND: The novel tandem genes mef(C) and mph(G) have been reported in marine bacteria in Japan. This paper aimed to characterise the extent of environmental distribution of mef(C) and mph(G) as well as their dissemination and persistence in aquatic bacterial communities. METHODS: Erythromycin-resistant bacteria were isolated from Japan, Taiwan and Thailand aquaculture sites. The mef(C)-mph(G) genes were detected by PCR. The size of mobile genetic elements conveying mef(C) and mph(G) was examined by Southern blotting...
July 6, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28687066/genomic-characterization-of-a-large-plasmid-containing-a-bla-ndm-1-gene-carried-on-salmonella-enterica-serovar-indiana-c629-isolate-from-china
#7
Wei Wang, Zulqarnain Baloch, Zixin Peng, Yujie Hu, Jin Xu, Séamus Fanning, Fengqin Li
BACKGROUND: The bla NDM-1 gene in Salmonella species is mostly reported in clinical cases, but is rarely isolated from red and white meat in China. METHODS: A Salmonella Indiana (S. Indiana) isolate was cultured from a chicken carcass procured from a slaughterhouse in China. Antimicrobial susceptibility was tested against a panel of agents. Whole-genome sequencing of the isolate was carried out and data was analyzed. RESULTS: A large plasmid, denoted as plasmid pC629 (210,106 bp), containing a composite cassette, consisting of IS26-bla NDM-1-ble MBL -△trpF-tat-cutA-ISCR1-sul1-qacE△1-aadA2-dfrA12-intI1-IS26 was identified...
July 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28678610/occupant-responses-in-conventional-and-abts-seats-in-high-speed-rear-sled-tests
#8
David C Viano, Chantal S Parenteau, Roger Burnett, Priya Prasad
OBJECTIVE: This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and ABTS (all belts to seat) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. METHODS: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration...
July 5, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28678180/mph-m-aodv-m-and-dsr-m-performance-evaluation-under-jamming-attacks
#9
Carolina Del-Valle-Soto, Carlos Mex-Perera, Raul Monroy, Juan A Nolazco-Flores
In this work, we present the design of a mitigation scheme for jamming attacks integrated to the routing protocols MPH, AODV, and DSR. The resulting protocols are named MPH-M (Multi-Parent Hierarchical - Modified), AODV-M (Ad hoc On Demand Distance Vector - Modified), and DSR-M (Dynamic Source Routing - Modified). For the mitigation algorithm, if the detection algorithm running locally in each node produces a positive result then the node is isolated; second, the routing protocol adapts their paths avoiding the isolated nodes...
July 5, 2017: Sensors
https://www.readbyqxmd.com/read/28669538/the-effect-of-methylphenidate-on-the-microstructure-of-schedule-induced-polydipsia-in-an-animal-model-of-adhd
#10
Javier Íbias, Carter W Daniels, Miguel Miguéns, Ricardo Pellón, Federico Sanabria
Schedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5mg/kg/d) for six consecutive SIP sessions. A test to assess possible sensitization effects was also conducted four days after termination of the drug treatment. At baseline, FT 90-s produced longer and more frequent drinking episodes in SHR than in WKY...
June 30, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28656805/verbal-working-memory-related-functional-connectivity-alterations-in-boys-with-attention-deficit-hyperactivity-disorder-and-the-effects-of-methylphenidate
#11
Zhao-Min Wu, Janita Bralten, Li An, Qing-Jiu Cao, Xiao-Hua Cao, Li Sun, Lu Liu, Li Yang, Maarten Mennes, Yu-Feng Zang, Barbara Franke, Martine Hoogman, Yu-Feng Wang
OBJECTIVE: Few studies have investigated verbal working memory-related functional connectivity patterns in participants with attention-deficit/hyperactivity disorder (ADHD). Thus, we aimed to compare working memory-related functional connectivity patterns in healthy children and those with ADHD, and study effects of methylphenidate (MPH). METHOD: Twenty-two boys with ADHD were scanned twice, under either MPH (single dose, 10 mg) or placebo, in a randomised, cross-over, counterbalanced placebo-controlled design...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28651152/methylphenidate-disintegration-from-oral-formulations-for-intravenous-use-by-experienced-substance-users
#12
G D Bjarnadottir, M Johannsson, A Magnusson, B O Rafnar, E Sigurdsson, S Steingrimsson, V Asgrimsson, I Snorradottir, H Bragadottir, H M Haraldsson
BACKGROUND AND AIMS: Methylphenidate (MPH) is a prescription stimulant used to treat attention-deficit hyperactivity disorder. MPH is currently the preferred substance among most intravenous (i.v.) substance users in Iceland. Four types of MPH preparations were available in Iceland at the time of study: Immediate-release (IR), sustained-release (SR), osmotic controlled-release oral delivery (OROS) tablet and osmotic-controlled release (OCR). MPH OROS has previously been rated the least desirable by i...
June 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28640060/individualized-estimation-of-physical-activity-in-older-adults-with-type-2-diabetes
#13
Whitney A Welch, Neil Alexander, Ann M Swartz, Nora E Miller, Erica Twardzik, Scott J Strath
PURPOSE: Compare physical activity intensity in older adults with T2DM using individualized, relative cutpoints with standard, absolute cutpoints. METHODS: One hundred older adults with T2DM (68.9±5.1y, 65% male, 32.7±6.3 kgm, 7.2±1.1% HbA1c) completed a two-speed walking protocol (varying, walking between 1-2.5 mph), followed by a modified Bruce peak exercise test. Participants wore an accelerometer-based physical activity monitor at their waist and oxygen consumption was measured...
June 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28633952/chronic-methylphenidate-regulates-genes-and-proteins-mediating-neuroplasticity-in-the-juvenile-rat-brain
#14
Emmanuel Quansah, Tiziana Sgamma, Estabraq Jaddoa, Tyra S C Zetterström
Methylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of chronic MPH (2.0mg/kg, twice daily for 15days) exposure to young rats (20-25days old at start of treatment) on the expression of genes and proteins associated with neuroplasticity, such as activity regulated cytoskeleton-associated protein (Arc), insulin receptor substrate protein 53 (IRSp53), cell division control protein 42 (Cdc42), and actin-related protein 2 (Arp2)...
June 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28630628/staphylococcus-saprophyticus-recovered-from-humans-food-and-recreational-waters-in-rio-de-janeiro-brazil
#15
Viviane Santos de Sousa, Ana Paula de Souza da-Silva, Leif Sorenson, Raphael Paiva Paschoal, Renata Fernandes Rabello, Eloiza Helena Campana, Márcia Soares Pinheiro, Lyssa Oliveira Ferreira Dos Santos, Natacha Martins, Ana Carolina Nunes Botelho, Renata Cristina Picão, Sérgio Eduardo Longo Fracalanzza, Lee Woodland Riley, George Sensabaugh, Beatriz Meurer Moreira
Staphylococcus saprophyticus is an important agent of urinary tract infection (UTI) in young women, but information about this pathogen in human microbiota and in common environment is lacking. The aim of this study was to characterize S. saprophyticus isolates from genitoanal microbiota of 621 pregnant women, 10 minas cheese packs, and five beaches in Rio de Janeiro city and compare PFGE profiles of these isolates with five UTI PFGE clusters described in this city. We investigated 65 S. saprophyticus isolates from microbiota, 13 from minas cheese, and 30 from beaches and 32 UTI isolates...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28616427/specific-genes-associated-with-adverse-events-of-methylphenidate-use-in-the-pediatric-population-a-systematic-literature-review
#16
REVIEW
Beinta Joensen, Morten Meyer, Lise Aagaard
The aim of this study was to review empirical studies examining associations between candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and adolescents. The PubMed, EMBASE, CINAHL, and Web of Science databases were searched from their inception until March 2017. We included empirically based articles on pharmacogenetic studies in 0-17-year-old patients that investigated associations between specific candidate genes, their polymorphisms, and reported AEs. We extracted information about study design, setting, type of AE reporter, studied genes and their polymorphisms, age and gender, administered doses, method of genotyping, outcome measures, and main findings...
April 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28616366/increased-energy-cost-of-mobility-in-chronic-stroke
#17
Monica C Serra, Margarita S Treuth, Charlene E Hafer-Macko, Alice S Ryan
The purpose of this study was to compare the energy cost of completing mobility-related activities in chronic stroke to the estimated energy cost found in the compendium of physical activities, a resource that estimates and classifies energy cost of various human physical activities. Men (n=18) and women (n=10) with chronic hemiparetic gait (stroke latency: 4 ± 2 years, age: 60.4 ± 1.6 years, BMI: 31.5 ± 1.1 kg/m(2)) participated in the study. Portable energy cost monitoring (COSMED K4b2) was performed during five mobility activities of varying intensity to determine metabolic equivalents (METs, or oxygen consumption in multiples of resting level) for each activity...
December 2016: Journal of Gerontology & Geriatric Research
https://www.readbyqxmd.com/read/28614475/-positioning-ecuador-in-the-global-health-agenda-as-a-result-of-sector-reform
#18
Cristina Luna, Carlos Andrés Emanuele, Daniel De La Torre
Objective: Analyze strategies implemented by Ecuador's Ministry of Public Health (MPH) to position the country in the global health agenda during the period 2011-2015 as a result of health sector reform. Method: Documentary review and interviews with stakeholders in national and international agencies with respect to positioning in the global health sphere during the study period. Results: It was observed that the reform process produced a new framework to manage international health relations...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28614472/-human-resources-for-health-in-ecuador-s-new-model-of-care
#19
Verónica Espinosa, Daniel de la Torre, Cecilia Acuña, Cristina Cadena
Objective: Describe strategies implemented by Ecuador's Ministry of Public Health (MPH) to strengthen human resources for health leadership and respond to the new model of care, as a part of the reform process in the period 2012-2015. Methods: A documentary review was carried out of primary and secondary sources on development of human resources for health before and after the reform. Results: In the study period, Ecuador developed a new institutional and regulatory framework for developing human resources for health to respond to the requirements of a model of care based on primary health care...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28599833/the-effects-of-methylphenidate-on-the-neural-signatures-of-sustained-attention
#20
Paul M Dockree, Jessica J Barnes, Natasha Matthews, Angela J Dean, Rafael Abe, L Sanjay Nandam, Simon P Kelly, Mark A Bellgrove, Redmond G O'Connell
BACKGROUND: Although it is well established that methylphenidate (MPH) enhances sustained attention, the neural mechanisms underpinning this improvement remain unclear. We examined how MPH influenced known electrophysiological precursors of lapsing attention over different time scales. METHODS: We measured the impact of MPH, compared with placebo, on behavioral and electrocortical markers while healthy adults (n = 40) performed a continuous monitoring paradigm designed to elicit attentional lapses...
May 10, 2017: Biological Psychiatry
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