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Immune veterinary

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https://www.readbyqxmd.com/read/29351196/a-case-report-of-disseminated-canine-histiocytic-sarcoma-in-trinidad-and-tobago
#1
Stacy Rajh, Karelma Frontera Acevedo, Gillian Williams, Indira Pargass, Alissa Bally, Rod Suepaul
Ocular histiocytic sarcomas (as a presenting part of disseminated histiocytic sarcoma) are not commonly diagnosed. A 10-year-old female intact Rottweiler presented to the School of Veterinary Medicine, Trinidad with buphthalmia and pain in the left eye. The cornea of the left eye appeared diffusely opaque with a conjunctival mucopurulent ocular discharge. A thorough ophthalmic assessment identified an intraocular proliferative tumor to which a unilateral enucleation was performed, however the animal died soon after...
January 19, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29328884/evaluation-of-g2-citric-acid-based-dendrimer-as-an-adjuvant-in-veterinary-rabies-vaccine
#2
Vahid Asgary, Alireza Shoari, Majid Afshar Moayad, Mehdi Shafiee Ardestani, Razieh Bigdeli, Leila Ghazizadeh, Mohammad Sadeq Khosravy, Erfan Panahnejad, Alireza Janani, Rouzbeh Bashar, Maliheh Abedi, Reza Ahangari Cohan
For induction of an appropriate immune response, especially in the case of an inactivated vaccine, the use of an adjuvant is crucial. In this study, adjuvanticity effect of G2 dendrimer in veterinary rabies vaccine has been investigated. A nonlinear globular G2 dendrimer comprising citric acid and polyethylene glycol 600 (PEG-600) was synthesized and the toxicity was studied in vitro on the J774A.1 cell line. The adjuvanticity effect of the dendrimer was then investigated on rabies virus in NMRI mice as a model...
January 2018: Viral Immunology
https://www.readbyqxmd.com/read/29316047/parainfluenza-virus-5-vectored-vaccines-against-human-and-animal-infectious-diseases
#3
REVIEW
Zhenhai Chen
Parainfluenza virus 5 (PIV5), known as canine parainfluenza virus in the veterinary field, is a negative-sense, nonsegmented, single-stranded RNA virus belonging to the Paramyxoviridae family. Parainfluenza virus 5 is an excellent viral vector and has been used as a live vaccine for kennel cough for many years in dogs without any safety concern. It can grow to high titers in many cell types, and its genome is stable even in the presence of foreign gene insertions. So far, PIV5 has been used to develop vaccines against influenza virus, respiratory syncytial virus, rabies virus, and Mycobacterium tuberculosis, demonstrating its ability to elicit robust and protective immune responses in preclinical animal models...
January 5, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29315275/a-pilot-qualitative-investigation-of-stakeholders-experiences-and-opinions-of-equine-insect-bite-hypersensitivity-in-england
#4
Hannah R Lomas, Philip A Robinson
Equine insect bite hypersensitivity (IBH), commonly known as sweet itch or summer eczema, is a frustrating recurrent skin disease in the equine industry involving an immune reaction to the bites of Culicoides spp. midges. To investigate the impact of IBH in the field, an exploratory pilot study was conducted with equine stakeholders in one region of central England. Nine semi-structured, face-to-face interviews were conducted with horse owners and an equine veterinarian. The aim was to gain an understanding of experiences with IBH, and to gauge opinions on the value of the various management strategies horse owners use to control IBH...
January 9, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29304133/development-and-testing-of-species-specific-elisa-assays-to-measure-ifn-%C3%AE-and-tnf-%C3%AE-in-bottlenose-dolphins-tursiops-truncatus
#5
Kirsten C Eberle, Stephanie K Venn-Watson, Eric D Jensen, Joanna LaBresh, Yvonne Sullivan, Laura Kakach, Randy E Sacco
Monitoring the immune status of cetaceans is important for a variety of health conditions. Assays to quantify cytokines, especially pro-inflammatory cytokines, could be employed, in addition to currently available diagnostic assays, to screen for alterations in the health status of an animal. Though a number of immunological assays are readily available for humans and mice, specific assays for many veterinary species, including cetaceans such as bottlenose dolphins (Tursiops truncatus), are more limited. Herein, we describe the development of IFN-gamma (IFN-γ) and TNF-alpha (TNF-α) enzyme-linked immunosorbent assays (ELISAs) specific to bottlenose dolphins...
2018: PloS One
https://www.readbyqxmd.com/read/29280974/harnessing-invariant-nkt-cells-to-improve-influenza-vaccines-a-pig-perspective
#6
REVIEW
Guan Yang, Jürgen A Richt, John P Driver
Invariant natural killer T (iNKT) cells are an "innate-like" T cell lineage that recognize glycolipid rather than peptide antigens by their semi-invariant T cell receptors. Because iNKT cells can stimulate an extensive array of immune responses, there is considerable interest in targeting these cells to enhance human vaccines against a wide range of microbial pathogens. However, long overlooked is the potential to harness iNKT cell antigens as vaccine adjuvants for domestic animal species that express the iNKT cell-CD1d system...
December 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29259271/clearance-of-a-persistent-picornavirus-infection-is-associated-with-enhanced-pro-apoptotic-and-cellular-immune-responses
#7
Carolina Stenfeldt, Michael Eschbaumer, George R Smoliga, Luis L Rodriguez, James Zhu, Jonathan Arzt
Long-term persistent viral infections cause substantial morbidity and associated economic losses in human and veterinary contexts. Yet, the mechanisms associated with establishment of persistent infections are poorly elucidated. We investigated immunomodulatory mechanisms associated with clearance versus persistence of foot-and-mouth disease virus (FMDV) in micro-dissected compartments of the bovine nasopharynx by microarray. The use of laser-capture microdissection allowed elucidation of differential gene regulation within distinct anatomic compartments critical to FMDV infection...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246165/a-veterinary-perspective-on-one-health-in-the-arctic
#8
REVIEW
Christian Sonne, Robert James Letcher, Bjørn Munro Jenssen, Jean-Pierre Desforges, Igor Eulaers, Emilie Andersen-Ranberg, Kim Gustavson, Bjarne Styrishave, Rune Dietz
Exposure to long-range transported industrial chemicals, climate change and diseases is posing a risk to the overall health and populations of Arctic wildlife. Since local communities are relying on the same marine food web as marine mammals in the Arctic, it requires a One Health approach to understand the holistic ecosystem health including that of humans. Here we collect and identify gaps in the current knowledge of health in the Arctic and present the veterinary perspective of One Health and ecosystem dynamics...
December 16, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29237479/birth-delivery-method-affects-expression-of-immune-genes-in-lung-and-jejunum-tissue-of-neonatal-beef-calves
#9
Carla Surlis, Keelan McNamara, Eoin O'Hara, Sinead Waters, Marijke Beltman, Joseph Cassidy, David Kenny
BACKGROUND: Caesarean section is a routine veterinary obstetrical procedure employed to alleviate dystocia in cattle. However, CS, particularly before the onset of labour, is known to negatively affect neonatal respiration and metabolic adaptation in humans, though there is little published information for cattle. The aim of this study was to investigate the effect of elective caesarean section (ECS) or normal trans-vaginal (TV) delivery, on lung and jejunal gene expression profiles of neonatal calves...
December 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29235397/leptospira-interrogans-outer-membrane-protein-lipl21-is-a-potent-inhibitor-of-neutrophil-myeloperoxidase
#10
Monica L Vieira, Aline F Teixeira, Giselle Pidde-Queiroz, Ana T C Ching, Denise V Tambourgi, Ana Lucia T O Nascimento, Heiko Herwald
Leptospirosis is a widespread zoonotic and neglected infectious disease of human and veterinary concern that is caused by pathogenic Leptospira species. After entrance in the host, pathogenic leptospires evade the host natural defense mechanisms in order to propagate and disseminate to multiple organs. Myeloperoxidase is an enzyme stored in neutrophils azurophilic granules, and is released upon neutrophil activation to produce mainly hypochlorous acid, a strong oxidant and potent antimicrobial agent. In the present investigation, we studied the modulation of myeloperoxidase activity by L...
December 13, 2017: Virulence
https://www.readbyqxmd.com/read/29219305/brucellosis-improved-diagnostics-and-vaccine-insights-from-synthetic-glycans
#11
David R Bundle, John McGiven
Brucellosis is a serious zoonotic bacterial disease that is ranked by the World Health Organization among the top seven "neglected zoonoses" that threaten human health and cause poverty. It is a costly, highly contagious disease that affects ruminants, cattle, sheep, goats, and other productive animals such as pigs. Symptoms include abortions, infertility, decreased milk production, weight loss, and lameness. Brucellosis is also the most common bacterial disease that is transmitted from animals to humans, with approximately 500 000 new human cases each year...
December 8, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29204222/paracoccidioidomycosis-current-perspectives-from-brazil
#12
REVIEW
Rinaldo Poncio Mendes, Ricardo de Souza Cavalcante, Sílvio Alencar Marques, Mariângela Esther Alencar Marques, James Venturini, Tatiane Fernanda Sylvestre, Anamaria Mello Miranda Paniago, Ana Carla Pereira, Julhiany de Fátima da Silva, Alexandre Todorovic Fabro, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli, Rosane Christine Hahn, Adriele Dandara Levorato
Background: This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis. Objectives: Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29190736/humoral-immune-response-against-two-surface-antigens-of-chlamydia-pecorum-in-vaccinated-and-naturally-infected-sheep
#13
Sankhya Bommana, Evelyn Walker, Marion Desclozeaux, Peter Timms, Adam Polkinghorne
Chlamydia pecorum is a globally recognised livestock pathogen due to the significant clinical and economic impact it poses to livestock producers. Routine serological diagnosis is through a complement fixation test (CFT), which is often criticised for cross-reactivity, poor sensitivity and specificity. Although serology remains the preferred method in veterinary diagnostic laboratories, serological assays based on surface antigens of C. pecorum have not been established until now. In this study, we evaluated the use of two chlamydial recombinant protein antigens (PmpG and MOMP-G) by a direct IgG ELISA method for detection of ovine anti-chlamydial antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/29181774/sequestering-of-damage-associated-molecular-patterns-damps-a-possible-mechanism-affecting-the-immune-stimulating-properties-of-aluminium-adjuvants
#14
Andreas Svensson, Tove Sandberg, Peter Siesjö, Håkan Eriksson
Aluminium-based adjuvants (ABAs) have been used in human and veterinary vaccines for decades, and for a long time, the adjuvant properties were believed to be mediated by an antigen depot at the injection site, prolonging antigen exposure to the immune system. The depot hypothesis is today more or less abandoned, and instead replaced by the assumption that ABAs induce an inflammation at the injection site. Induction of an inflammatory response is consistent with immune activation initiated by recognition of molecular patterns associated with danger or damage (DAMPs), and the latter are derived from endogenous molecules that normally reside intracellularly...
November 27, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29178506/complications-and-short-term-outcomes-associated-with-single-port-laparoscopic-splenectomy-in-dogs
#15
Philipp D Mayhew, Jessie S Sutton, Ameet Singh, Jeffrey J Runge, J Brad Case, Maureen A Griffin, Michelle A Giuffrida
OBJECTIVE: To describe a technique and report complications and outcome for single-port laparoscopic splenectomy in dogs. STUDY DESIGN: Retrospective study. ANIMALS: Twenty-two client-owned dogs. METHODS: Medical records of dogs that underwent single-port laparoscopic splenectomy at 4 veterinary teaching hospitals were evaluated. Commercially available single-port devices were used in all dogs. In all cases, a vessel-sealing device was used to perform a hilar splenectomy...
November 27, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29155877/immune-response-profiles-of-calves-following-vaccination-with-live-bcg-and-inactivated-mycobacterium-bovis-vaccine-candidates
#16
E M D L van der Heijden, J Chileshe, J C M Vernooij, C Gortazar, R A Juste, I Sevilla, J E Crafford, V P M G Rutten, A L Michel
Conventional control and eradication strategies for bovine tuberculosis (BTB) face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations...
2017: PloS One
https://www.readbyqxmd.com/read/29140260/vaccinia-virus-natural-infections-in-brazil-the-good-the-bad-and-the-ugly
#17
REVIEW
Jaqueline Silva de Oliveira, Poliana de Oliveira Figueiredo, Galileu Barbosa Costa, Felipe Lopes de Assis, Betânia Paiva Drumond, Flávio Guimarães da Fonseca, Maurício Lacerda Nogueira, Erna Geessien Kroon, Giliane de Souza Trindade
The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remain unknown. VACV was the primary component of the smallpox vaccine, largely used during the smallpox eradication campaign. After smallpox was declared eradicated, the vaccination that conferred immunity to OPV was discontinued, favoring a new contingent of susceptible individuals to OPV...
November 15, 2017: Viruses
https://www.readbyqxmd.com/read/29131390/immune-function-in-critically-ill-dogs
#18
D Hoffman, J Amorim, A DeClue
BACKGROUND: People with critical illness (CI) commonly develop various forms of immune dysfunction, however, there is limited information concerning immune dysfunction in dogs with CI. HYPOTHESIS: The immune response in CI dogs differs from that of healthy dogs. ANIMALS: Immunologic variables were compared between 14 dogs with CI, defined as APPLEfast score of >20 points, admitted to the University of Missouri Veterinary Health Center Small Animal Clinic Intensive Care Unit and healthy controls (n = 15)...
November 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29126143/understanding-how-dogs-age-longitudinal-analysis-of-markers-of-inflammation-immune-function-and-oxidative-stress
#19
Janet E Alexander, Alison Colyer, Richard M Haydock, Michael G Hayek, JeanSoon Park, Rafael de Cabo
As in human populations, advances in nutrition and veterinary care have led to an increase in the lifespan of companion animals. Detrimental physiological changes occurring later in life must be understood before interventions can be made to slow or reduce them. One important aspect of human aging is upregulation of the inflammatory response and increase in oxidative damage resulting in pathologies linked to chronic inflammation. To determine whether similar processes occur in the aging dog, changes in markers of inflammation and oxidative stress were investigated in 80 Labrador retrievers from adulthood to the end of life...
November 6, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29121394/larval-echinococcus-multilocularis-infection-reduces-dextran-sulfate-sodium-dss-induced-colitis-in-mice-by-attenuating-th1-th17-mediated-immune-reactions
#20
Junhua Wang, Christine Goepfert, Norbert Mueller, Alessandra Piersigilli, Renyong Lin, Hao Wen, Dominique A Vuitton, Lucine Vuitton, Christoph Mueller, Bruno Gottstein
The tumor-like growth of larval Echinococcus multilocularis tissue (causing alveolar echinococcosis, AE) is directly linked to the nature/orientation of the periparasitic host immune-mediated processes. Parasite-mediated immune suppression is a hallmark triggering infection outcome in both chronic human and murine AE. So far, little is known about secondary systemic immune effects of this pathogen on other concomitant diseases, e.g. endogenous gut inflammation. We examined the influence of E. multilocularis infection on murine Dextran sodium sulfate (DSS)-induced colitis...
November 9, 2017: Immunology
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