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Immune veterinary

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https://www.readbyqxmd.com/read/28926584/transcriptome-analysis-reveals-molecular-anthelmintic-effects-of-procyanidins-in-c-elegans
#1
Verena Spiegler, Andreas Hensel, Jochen Seggewiß, Milena Lubisch, Eva Liebau
Worldwide, more than 1 billion people are affected by infestations with soil-transmitted helminths and also in veterinary medicine helminthiases are a severe threat to livestock due to emerging resistances against the common anthelmintics. Proanthocyanidins have been increasingly investigated for their anthelmintic properties, however, except for an interaction with certain proteins of the nematodes, not much is known about their mode of action. To investigate the anthelmintic activity on a molecular level, a transcriptome analysis was performed in Caenorhabditis elegans after treatment with purified and fully characterized oligomeric procyanidins (OPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28906208/pattern-recognition-receptors-signaling-pathways-and-dysregulation-in-canine-chronic-enteropathies-brief-review
#2
Romy M Heilmann, Karin Allenspach
Pattern-recognition receptors (PRRs) are expressed by innate immune cells and recognize pathogen-associated molecular patterns (PAMPs) as well as endogenous damage-associated molecular pattern (DAMP) molecules. With a large potential for synergism or convergence between their signaling pathways, PRRs orchestrate a complex interplay of cellular mediators and transcription factors, and thus play a central role in homeostasis and host defense. Aberrant activation of PRR signaling, mutations of the receptors and/or their downstream signaling molecules, and/or DAMP/PAMP complex-mediated receptor signaling can potentially lead to chronic auto-inflammatory diseases or development of cancer...
September 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28895862/immunomodulatory-effects-of-soluble-factors-secreted-by-feline-adipose-tissue-derived-mesenchymal-stem-cells
#3
Hyung-Kyu Chae, Woo-Jin Song, Jin-Ok Ahn, Qiang Li, Bo-Yeon Lee, Kyeong Kweon, Sang-Chul Park, Hwa-Young Youn
Mesenchymal stem cells (MSCs) have immunomodulatory functions and differentiation capacity, and their clinical use is increasing in veterinary species. Although MSCs have been applied in the treatment in various inflammatory diseases, mechanistic research on feline MSCs is lacking. Accordingly, in this study, we aimed to investigate the immunomodulatory mechanisms of MSCs isolated from feline adipose tissue (fATMSCs). fATMSCs from healthy cats were cultured in an appropriate manner and cocultured with transwell-separated allogeneic feline peripheral blood mononuclear cells (fPBMCs) and RAW264...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28887897/opportunistic-invasive-cutaneous-fungal-infections-associated-with-administration-of-cyclosporine-to-dogs-with-immune-mediated-disease
#4
B B McAtee, K J Cummings, A K Cook, J A Lidbury, J C Heseltine, M D Willard
BACKGROUND: Opportunistic invasive fungal infections (OIFIs) occur in dogs administered immunosuppressive medications. However, the epidemiology of OIFIs among dogs undergoing immunosuppressive treatment is poorly understood. The aims of this study were to (1) estimate the incidence of OIFIs among dogs diagnosed with certain immune-mediated diseases and treated with immunosuppressive drugs, and (2) determine if administration of particular drug(s) was a risk factor for OIFIs. HYPOTHESIS: Dogs receiving cyclosporine treatment (alone or as part of a multidrug protocol) are at higher risk of developing OIFIs...
September 9, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28882176/use-of-the-mice-passive-protection-test-to-evaluate-the-humoral-response-in-goats-vaccinated-with-sterne-34f2-live-spore-vaccine
#5
P H Phaswana, O C Ndumnego, S M Koehler, W Beyer, J E Crafford, H van Heerden
The Sterne live spore vaccine (34F2) is the most widely used veterinary vaccine against anthrax in animals. Antibody responses to several antigens of Bacillus anthracis have been described with a large focus on those against protective antigen (PA). The focus of this study was to evaluate the protective humoral immune response induced by the live spore anthrax vaccine in goats. Boer goats vaccinated twice (week 0 and week 12) with the Sterne live spore vaccine and naive goats were used to monitor the anti-PA and toxin neutralizing antibodies at week 4 and week 17 (after the second vaccine dose) post vaccination...
September 7, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28882137/methodology-for-the-assessment-of-brucellosis-management-practices-and-its-vaccination-campaign-example-in-two-argentine-districts
#6
M N Aznar, M Arregui, M F Humblet, L E Samartino, C Saegerman
BACKGROUND: In Argentina, vaccination with Brucella abortus Strain 19 vaccine is mandatory. The objective of the study was to develop and test a method for evaluating, in an innovative way, some farmers' and veterinarians' management practices in relation to brucellosis and to assess the vaccination campaign and coverage. The work took place in Brandsen and Navarro districts. Four questionnaires were designed (for officials from Local Sanitary Entities, vaccinators, vet practitioners and farmers)...
September 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28869356/a-plant-produced-candidate-subunit-vaccine-reduces-shedding-of-enterohemorrhagic-escherichia-coli-in-ruminants
#7
Sean Miletic, Martin Hünerberg, Angelo Kaldis, Jacqueline MacDonald, Antoine Leuthreau, Tim McAllister, Rima Menassa
Enterohemorrhagic Escherichia coli (EHEC) are commonly present in the gastrointestinal tract of cattle and cause serious infectious disease in humans. Immunizing cattle against EHEC is a promising strategy to decrease the risk of food contamination; however, veterinary vaccines against EHEC such as Econiche have not been widely adopted by the agricultural industry, and have been discontinued, prompting the need for more cost-effective EHEC vaccines. The objective of this project was to develop a platform to produce plant-made antigens for oral vaccination of ruminants against EHEC...
September 4, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28857700/evaluation-of-the-immunocrit-method-to-detect-failure-of-passively-acquired-immunity-in-dairy-calves
#8
Kimberly A Thompson, Marie C Rayburn, Munashe Chigerwe
OBJECTIVE To evaluate the usefulness of serum immunocrit measurement to detect failure of passively acquired immunity (FPI) in dairy calves. DESIGN Diagnostic test evaluation. ANIMALS 249 female dairy calves (age, 2 to 6 days). PROCEDURES A blood sample was collected from each calf, and serum was harvested. Immunocrit was measured in serum samples by use of 55% ammonium sulfate solution and the standard technique. Serum IgG concentration was measured by means of radial immunodiffusion (reference standard), with FPI defined as a result < 1,000 mg/dL...
September 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28835840/coupling-gene-based-and-classic-veterinary-diagnostics-improves-interpretation-of-health-and-immune-function-in-the-agassiz-s-desert-tortoise-gopherus-agassizii
#9
K Kristina Drake, Lizabeth Bowen, Rebecca L Lewison, Todd C Esque, Kenneth E Nussear, Josephine Braun, Shannon C Waters, A Keith Miles
The analysis of blood constituents is a widely used tool to aid in monitoring of animal health and disease. However, classic blood diagnostics (i.e. hematologic and plasma biochemical values) often do not provide sufficient information to determine the state of an animal's health. Field studies on wild tortoises and other reptiles have had limited success in drawing significant inferences between blood diagnostics and physiological and immunological condition. However, recent research using gene transcription profiling in the threatened Mojave desert tortoise (Gopherus agassizii) has proved useful in identifying immune or physiologic responses and overall health...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28802692/de-novo-transcriptome-assembly-and-rna-seq-expression-analysis-in-blood-from-beluga-whales-of-bristol-bay-ak
#10
Jeanine S Morey, Kathy A Burek Huntington, Michelle Campbell, Tonya M Clauss, Caroline E Goertz, Roderick C Hobbs, Denise Lunardi, Amanda J Moors, Marion G Neely, Lori H Schwacke, Frances M Van Dolah
Assessing the health of marine mammal sentinel species is crucial to understanding the impacts of environmental perturbations on marine ecosystems and human health. In Arctic regions, beluga whales, Delphinapterus leucas, are upper level predators that may serve as a sentinel species, potentially forecasting impacts on human health. While gene expression profiling from blood transcriptomes has widely been used to assess health status and environmental exposures in human and veterinary medicine, its use in wildlife has been limited due to the lack of available genomes and baseline data...
August 9, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28763127/european-veterinary-renal-pathology-service-a-survey-over-a-7-year-period-2008-2015
#11
L Aresu, V Martini, S L Benali, C Brovida, R E Cianciolo, R Dalla Riva, D Trez, J J Van Der Lugt, A Van Dongen, E Zini
BACKGROUND: The European Veterinary Renal Pathology Service (EVRPS) is the first Web-based registry for canine renal biopsy specimens in Europe. HYPOTHESIS/OBJECTIVES: The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS. ANIMALS: Renal biopsy specimens of dogs were collected from the archive of the service (n = 254)...
September 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28759334/b-cell-tetramer-development-for-veterinary-vaccinology
#12
Michael C Rahe, Kevin L Gustafson, Michael P Murtaugh
Immunological memory is elicited after either vaccination or natural exposure to a pathogen and is essential for protection against re-exposure. Despite its critical importance, the ability to interrogate the veterinary animal memory immune response has long been hindered by a paucity of tools to assess immunological memory. As a result, the evaluation and analysis of protective immune responses that predict immune protection in food and fiber animals and facilitate vaccine development are obstructed. To fill this gap in knowledge in swine, we created a B cell tetramer to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 7 (nsp7) to efficiently and effectively investigate the memory B cell response, a hallmark of anti-viral immunity...
July 31, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28755414/successful-use-of-digoxin-specific-immune-fab-in-the-treatment-of-severe-nerium-oleander-toxicosis-in-a-dog
#13
Amaris Pao-Franco, Tara N Hammond, Linda K Weatherton, Camille DeClementi, Scott D Forney
OBJECTIVE: To describe a case in which digoxin-specific immune Fab was used successfully in a dog with severe oleander toxicosis secondary to ingesting plant material. CASE SUMMARY: A 6-year-old intact female Rhodesian Ridgeback mixed breed dog was presented for severe oleander toxicosis and was refractory to all antiarrhythmic therapies and supportive care. Digoxin-specific immune Fab was successful in treating this dog. The dog recovered but suffered ischemic injuries, the long-term effects of which are unknown...
September 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28749750/microbial-offense-vs-host-defense-who-controls-the-tb-granuloma
#14
Amanda J Martinot
The granuloma is the hallmark of tuberculosis and simultaneously signifies acquisition of an infection and induction of a host immune response. But who benefits more from the development of the granuloma, the host or the pathogen? Is microbe or man dictating disease course and progression? Mycobacterial diseases affect humans and animals alike, and the concepts presented in this review reflect host-pathogen interactions that influence not only mycobacterial granulomas in humans and animals but also other infectious granulomatous diseases that are encountered in veterinary medicine...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28711432/inactivated-orf-virus-shows-disease-modifying-antiviral-activity-in-a-guinea-pig-model-of-genital-herpesvirus-infection
#15
Astrid Friebe, Angela Siegling, Olaf Weber
BACKGROUND: Inactivated Orf virus (iORFV) has been used as a preventative as well as a therapeutic immunomodulator in veterinary medicine in different species. iORFV elicits strong effects on cytokine secretion in mice and human immune cells leading to an auto-regulated loop of initial up-regulation of inflammatory and Th1-related cytokines followed by Th2-related cytokines that attenuate immunopathology. The therapeutic potential of iORFV has been recognized in several models for difficult-to-treat disease areas such as chronic viral diseases, liver fibrosis or various forms of cancer...
June 27, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28651194/reference-intervals-for-hematological-and-biochemical-parameters-acute-phase-proteins-and-markers-of-oxidation-in-holstein-dairy-cows-around-3-and-30days-after-calving
#16
Pierangelo Moretti, Saverio Paltrinieri, Erminio Trevisi, Monica Probo, Annarita Ferrari, Andrea Minuti, Alessia Giordano
The establishment of specific reference intervals (RIs) is advisable when different metabolic conditions in the patient population are present or when existing RIs are not suitable. Holstein dairy cows, at the start of lactation, experience a negative energy balance and an altered immune function that can lead to different levels of blood parameters compared with cows at peak lactation. The aim of this study was the determination of RIs for Holstein cows at 3±1 and 30±3days in milk. To this aim, 145 cows, from 4 herds, were sampled...
June 20, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28642842/the-tick-microbiome-why-non-pathogenic-microorganisms-matter-in-tick-biology-and-pathogen-transmission
#17
REVIEW
Sarah I Bonnet, Florian Binetruy, Angelica M Hernández-Jarguín, Olivier Duron
Ticks are among the most important vectors of pathogens affecting humans and other animals worldwide. They do not only carry pathogens however, as a diverse group of commensal and symbiotic microorganisms are also present in ticks. Unlike pathogens, their biology and their effect on ticks remain largely unexplored, and are in fact often neglected. Nonetheless, they can confer multiple detrimental, neutral, or beneficial effects to their tick hosts, and can play various roles in fitness, nutritional adaptation, development, reproduction, defense against environmental stress, and immunity...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28639138/veterinary-vaccine-nanotechnology-pulmonary-and-nasal-delivery-in-livestock-animals
#18
REVIEW
Daniella Calderon-Nieva, Kalhari Bandara Goonewardene, Susantha Gomis, Marianna Foldvari
Veterinary vaccine development has several similarities with human vaccine development to improve the overall health and well-being of species. However, veterinary goals lean more toward feasible large-scale administration methods and low cost to high benefit immunization. Since the respiratory mucosa is easily accessible and most infectious agents begin their infection cycle at the mucosa, immunization through the respiratory route has been a highly attractive vaccine delivery strategy against infectious diseases...
August 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28604157/advancements-in-dna-vaccine-vectors-non-mechanical-delivery-methods-and-molecular-adjuvants-to-increase-immunogenicity
#19
John J Suschak, James A Williams, Connie S Schmaljohn
A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses. DNA vaccines are currently used in veterinary medicine, but have not achieved widespread acceptance for use in humans due to their low immunogenicity in early clinical studies. However, recent clinical data have re-established the value of DNA vaccines, particularly in priming high-level antigen-specific antibody responses. Several approaches have been investigated for improving DNA vaccine efficacy, including advancements in DNA vaccine vector design, the inclusion of genetically engineered cytokine adjuvants, and novel non-mechanical delivery methods...
June 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28583218/demodex-canis-regulates-cholinergic-system-mediated-immunosuppressive-pathways-in-canine-demodicosis
#20
P Kumari, R Nigam, A Singh, U P Nakade, A Sharma, S K Garg, S K Singh
Demodex canis infestation in dogs remains one of the main challenges in veterinary dermatology. The exact pathogenesis of canine demodicosis is unknown but an aberration in immune status is considered very significant. No studies have underpinned the nexus between induction of demodicosis and neural immunosuppressive pathways so far. We have evaluated the involvement of cholinergic pathways in association with cytokines regulation as an insight into the immuno-pathogenesis of canine demodicosis in the present study...
June 6, 2017: Parasitology
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