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https://www.readbyqxmd.com/read/27904177/a-clinicopathological-analysis-of-primary-cutaneous-lymphomas-a-6-year-observational-study-at-a-tertiary-care-center-of-south-india
#1
Anza Khader, Shiny Padinjarayil Manakkad, Mohammed Shaan, Sarita Sasidharan Pillai, Najeeba Riyaz, P Binitha Manikoth, Muhammed Kunnummel, Sunitha Balakrishnan
BACKGROUND: Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India. AIM: To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patients. MATERIALS AND METHODS: This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27894665/modulatory-effects-of-curcumin-on-apoptosis-and-cytotoxicity-related-molecules-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#2
Asadollah Mohammadi, Bahare Fazeli, Marzieh Taheri, Amirhossein Sahebkar, Zohreh Poursina, Vida Vakili, Shadi Zamanian Yazdi, Zahra Keramati, Reza Boostani, Ian Hampson, Houshang Rafatpanah
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic viral neuroinflammatory disease. Apoptosis might play an important role in the control of HTLV-1 viral infection. This study aims to determine if apoptosis process being able to occasionally distinguish between asymptomatic carriers (ACs) and HAM/TSP patients. Therefore, it could be used to predict the outcome of HTLV-1 infection. The mRNA expression of perforin, granzyme A, granzyme B, granulysin, Fas-Ligand (FasL), TNF-related apoptosis-inducing ligand (TRAIL), total Fas and membrane Fas in 21 HAM/TSP patients, 21 ACs and 21 healthy controls (HCs) was quantified...
November 25, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27893842/t-cell-receptor-v%C3%AE-staining-identifies-the-malignant-clone-in-adult-t-cell-leukemia-and-reveals-killing-of-leukemia-cells-by-autologous-cd8-t-cells
#3
Aileen G Rowan, Aviva Witkover, Anat Melamed, Yuetsu Tanaka, Lucy B M Cook, Paul Fields, Graham P Taylor, Charles R M Bangham
There is growing evidence that CD8+ cytotoxic T lymphocyte (CTL) responses can contribute to long-term remission of many malignancies. The etiological agent of adult T-cell leukemia/lymphoma (ATL), human T lymphotropic virus type-1 (HTLV-1), contains highly immunogenic CTL epitopes, but ATL patients typically have low frequencies of cytokine-producing HTLV-1-specific CD8+ cells in the circulation. It remains unclear whether patients with ATL possess CTLs that can kill the malignant HTLV-1 infected clone. Here we used flow cytometric staining of TCRVβ and cell adhesion molecule-1 (CADM1) to identify monoclonal populations of HTLV-1-infected T cells in the peripheral blood of patients with ATL...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27887847/role-of-the-htlv-1-viral-factors-in-the-induction-of-apoptosis
#4
REVIEW
Mohammad Karimi, Hamed Mohammadi, Maryam Hemmatzadeh, Asadollah Mohammadi, Houshang Rafatpanah, Behzad Baradaran
Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways...
November 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27879458/the-changing-epidemiology-of-human-t-cell-lymphotropic-virus-type-1-infection-in-peruvian-female-sex-workers-1993-2010
#5
Jenell Stewart, Kristen Heitzinger, Simon Pollett, Martha Calderón, Jorge Alarcón, Thanh G N Ton, Joseph R Zunt
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to be reported and is associated with neoplastic, neurological, autoimmune, and infectious complications. HTLV-1 is endemic in Peru, with the highest prevalence reported among commercial sex workers. Seroprevalence data collected from Peruvian female sex workers (FSWs) working in Callao over three study periods between 1993 and 2010 were used to examine the secular trend in HTLV-1 prevalence. Between 1993 and 2010, the prevalence of HTLV-1 decreased significantly from 14...
November 22, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27872619/ebola-vp40-in-exosomes-can-cause-immune-cell-dysfunction
#6
Michelle L Pleet, Allison Mathiesen, Catherine DeMarino, Yao A Akpamagbo, Robert A Barclay, Angela Schwab, Sergey Iordanskiy, Gavin C Sampey, Benjamin Lepene, Sergei Nekhai, M J Aman, Fatah Kashanchi
Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of causing severe hemorrhagic fever with up to 80-90% mortality rates. The most recent outbreak of EBOV in West Africa starting in 2014 resulted in over 11,300 deaths; however, long-lasting persistence and recurrence in survivors has been documented, potentially leading to further transmission of the virus. We have previously shown that exosomes from cells infected with HIV-1, HTLV-1 and Rift Valley Fever virus are able to transfer viral proteins and non-coding RNAs to naïve recipient cells, resulting in an altered cellular activity...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27871430/htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-a-comparative-study-to-identify-factors-that-influence-disease-progression
#7
Eiji Matsuura, Satoshi Nozuma, Yuichi Tashiro, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima
OBJECTIVE: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can progress slowly or rapidly even though a set of symptoms such as spastic paraparesis with pathological reflexes and sweating loss of the lower extremities are commonly observed in patients. Although most of the patients are thought to be infected to HTLV-1 from their mothers by breast feeding, symptoms of HAM/TSP typically manifest in patients later in life (50-60years old in age) and also with a higher prevalence of women to men at a ratio of approximately 3:1...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27868052/friend-or-foe-mogamulizumab-in-allogeneic-hematopoietic-stem-cell-transplantation-for-adult-t-cell-leukemia-lymphoma
#8
REVIEW
Shigeo Fuji, Takero Shindo
Adult T-cell leukemia/lymphoma (ATL/ATLL) is a peripheral T-cell neoplasm associated with human T-lymphotropic virus type-1 (HTLV-1). Even the currently most intensive chemotherapy regimen modified LSG15 (mLSG15, VCAP-AMP-VECP) results in a dismal clinical outcome, with a median overall survival of only around 1 year. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) may lead to long-term remission in a proportion of patients with aggressive ATL, the clinical outcome in patients with refractory or relapsed ATL is unsatisfactory...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/27860061/strongyloides-hyperinfection-following-hematopoietic-stem-cell-transplant-in-a-patient-with-htlv-1-associated-t-cell-leukemia
#9
Jonathan D Alpern, Sophie S Arbefeville, Gregory Vercellotti, Patricia Ferrieri, Jaime S Green
Strongyloides stercoralis has the potential to cause accelerated autoinfection in immunocompromised hosts. Screening tests for strongyloidiasis may be falsely negative in the setting of immunosuppression. We report a case of Strongyloides hyperinfection syndrome in a patient with human T-lymphotropic virus type 1-associated T-cell leukemia early after hematopoietic stem cell transplant. The diagnosis was made by stool ova and parasite examination, despite a negative screening enzyme-linked immunosorbent assay...
November 17, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27845163/the-effect-of-htlv-1-virulence-factors-hbz-tax-proviral-load-hla-class-i-and-plasma-neopterin-on-manifestation-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#10
Hanieh Tarokhian, Mahdi Taghadosi, Hushang Rafatpanah, Taraneh Rajaei, Mahmoud Reza Azarpazhooh, Narges Valizadeh, S A Rahim Rezaee
BACKGROUND: Previous studies have suggested debatable roles of Tax and HBZ gene expression in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this study, HTLV-1 and host interactions in the manifestation of HAM/TSP were evaluated. METHODS: A cross-sectional study was conducted on 33 HAM/TSP patients and 38 HTLV-1 asymptomatic carriers (ACs). HTLV-1-Tax, HBZ gene expression, and proviral load (PVL) were assessed using the quantitative real-time PCR (TaqMan), host plasma neopterin level, and HLA-I, and the clinical manifestation were evaluated...
November 12, 2016: Virus Research
https://www.readbyqxmd.com/read/27844017/design-of-new-potent-htlv-1-protease-inhibitors-in-silico-study
#11
Mitra Kheirabadi, Javad Maleki, Safieh Soufian, Samaneh Hosseini
HTLV-1 and HIV-1 are two major causes for severe T-cell leukemia disease and acquired immune deficiency syndrome (AIDS). HTLV-1 protease, a member of aspartic acid protease family, plays important roles in maturation during virus replication cycle. The impairment of these proteases results in uninfectious HTLV-1virions.Similar to HIV-1protease deliberate mutations that confer drug resistance on HTLV-1 are frequently seen in this protease. Therefore, inhibition of HTLV-1 protease activity is expected to disrupt HTLV-1's ability to replicate and infect additional cells...
March 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/27830995/oncogenic-role-of-tumor-viruses-in-humans
#12
Nimrah Akram, Muhammad Imran, Mamoona Noreen, Fayyaz Ahmed, Muhammad Atif, Zareen Fatima, Ahmed Bilal Waqar
Viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. Viral replications can affect cellular genes of the host in multiple cancerous ways. Approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. Viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. Oncogenesis is a multistep phenomenon in which normal host cells are transformed into cancerous cells on the basis of host genetic variability...
November 10, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27829440/wrn-targeted-therapy-using-inhibitors-nsc-19630-and-nsc-617145-induce-apoptosis-in-htlv-1-transformed-adult-t-cell-leukemia-cells
#13
R Moles, X T Bai, H Chaib-Mezrag, C Nicot
BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) infection is associated with adult T-cell leukemia/lymphoma (ATLL), a lymphoproliferative malignancy with a dismal prognosis and limited therapeutic options. Recent evidence shows that HTLV-1-transformed cells present defects in both DNA replication and DNA repair, suggesting that these cells might be particularly sensitive to treatment with a small helicase inhibitor. Because the "Werner syndrome ATP-dependent helicase" encoded by the WRN gene plays important roles in both cellular proliferation and DNA repair, we hypothesized that inhibition of WRN activity could be used as a new strategy to target ATLL cells...
November 9, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27824250/evidence-of-sexual-transmission-of-htlv-1-with-orf-1-g29s-mutation-among-humans
#14
Carolina Rosadas, Ana Carolina Vicente, Louise Zanella, Mauro Jorge Cabral-Castro, José Mauro Peralta, Marzia Puccioni-Sohler
NA.
November 8, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27822257/co-infection-of-the-hepatitis-c-virus-with-other-blood-borne-and-hepatotropic-viruses-among-hemophilia-patients-in-poland
#15
Marta Kucharska, Malgorzata Inglot, Aleksandra Szymczak, Weronika Rymer, Malgorzata Zalewska, Krzysztof Malyszczak, Urszula Zaleska-Dorobisz, Malgorzata Kuliszkiewicz-Janus
BACKGROUND: The prevalence of HCV infection in people with hemophilia is substantially higher than that in the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk of HBV and HIV transmission. However, the prevalence of other blood-borne viral infections in this population is less well known. OBJECTIVES: This study aimed to assess the prevalence of co-infection with HBV and other blood-borne viruses in Polish HCV-infected hemophiliacs...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27812668/human-t-cell-lymphotropic-virus-1-infection-three-infected-generations-in-the-same-family
#16
Marcela Sena Teixeira Mendes, Mariana Carvalho Costa, Izelda Maria Carvalho Costa
The human T-cell lymphotropic virus-1 (HTLV-1) affects worldwide population; the estimated number of currently infected individuals is 10-20 million. In this report, we describe the clinical findings of three family members with vertical transmission of HTLV-1. This case report highlights the importance of healthcare providers who have optimal knowledge about HTLV-1 including its transmission and pertinent attributes, and who are able to provide affected individuals with adequate information regarding their condition...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27812253/jak2-v617f-mutation-in-adult-t-cell-leukemia-lymphoma
#17
Hossein Ayatollahi, Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Ehsan Ghayoor Karimiani, Amir Hossein Jafarian, Abbas Shirdel, Hossein Rahimi, Mohammad Esmaeel Zangane-Far, Arezoo Shajiei, Maryam Sheikhi
Adult T cell Leukemia/lymphoma (ATL) is a mature T-cell neoplasm that has strong association with the human T-lymphotropic virus type 1 (HTLV-I) infection. This infection is endemic in our region (north eastern Iran). It has been highlighted that Janus Kinase family proteins and specially JAK2 mutations have a pivotal role in the development of many types of hematological malignancies and in particular myeloproliferative neoplasms. So far, the underlying molecular mechanisms leading to the ATL are not well understood...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27795537/htlv-1-targeted-immunotherapy
#18
Youko Suehiro
Adult T-cell leukemia/lymphoma (ATL) is a HTLV-1 induced T-cell malignancy with an extremely poor prognosis. There is a long latency period between HTLV-1 infection and the onset of ATL, which indicates the existence of multistep mechanisms of leukemogenesis in the infected cells. Tax, which is encoded by the HTLV-1 pX region, plays a crucial role in HTLV-1 leukemogenesis and is a major target of CTL. We developed an anti-ATL therapeutic vaccine consisting of autologous dendritic cells that is pulsed with Tax peptides (Tax-DC)...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27795530/allogeneic-hematopoietic-stem-cell-transplantation-for-adult-t-cell-leukemia-lymphoma
#19
Atae Utsunomiya
Long survival is obtained in 30-40% of adult T-cell leukemia-lymphoma (ATL) patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT) using HLA-matched related or unrelated donors. Myeloablative conditioning is generally used for patients 55 years of age and older, while reduced intensity conditioning is given to those between 50-70 years of age. Overall survival periods do not differ significantly between these two conditioning methods. Survival rates with cord blood transplantation are not inferior to those obtained with bone marrow transplantation or peripheral blood stem cell transplantation...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27795529/how-does-htlv-1-induce-atl
#20
Masao Matsuoka
Human T-cell leukemia virus type 1 (HTLV-1) spreads through cell-to-cell transmission in vivo. HTLV-1 mainly infects CD4+ T cells in vivo. Viral genes enable infected cells to proliferate and escape detection by the host immune system. HTLV-1 infected cells tend to infiltrate tissues, and enter breast milk and semen, thereby infecting a new host. HTLV-1 bZIP factor (HBZ) causes overproduction of interferon gamma, which is associated with inflammation and lymphomagenesis. Thus, the strategies by which HTLV-1 proliferates and survives in infected cells are promoted, which is thought to induce ATL and inflammatory diseases in infected individuals...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
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