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https://www.readbyqxmd.com/read/28910419/il-10-mediated-signals-act-as-a-switch-for-lymphoproliferation-in-human-t-cell-leukemia-virus-type-1-infection-by-activating-the-stat3-and-irf4-pathways
#1
Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi
Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since there are no disease-specific differences among HTLV-1 strains, the etiological mechanisms separating these respective lymphoproliferative and inflammatory diseases are not well understood. In this study, by using IL-2-dependent HTLV-1-infected T-cell lines (ILTs) established from patients with ATL and HAM/TSP, we demonstrate that the anti-inflammatory cytokine IL-10 and its downstream signals potentially act as a switch for proliferation in HTLV-1-infected cells...
September 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28905463/epidemiological-and-clinical-features-of-adult-t-cell-leukemia-lymphoma-atl-in-japan-2010-2011-a-nationwide-survey
#2
Kisato Nosaka, Masako Iwanaga, Yoshitaka Imaizumi, Kenji Ishitsuka, Kenichi Ishizawa, Yoji Ishida, Masahiro Amano, Takashi Ishida, Naokuni Uike, Atae Utsunomiya, Koichi Ohshima, Kazuhiro Kawai, Junji Tanaka, Yoshiki Tokura, Kensei Tobinai, Toshiki Watanabe, Kaoru Uchimaru, Kunihiro Tsukasaki
Adult T-cell leukemia-lymphoma (ATL) is a mature T-cell malignancy associated with human T-cell leukemia virus type I (HTLV-1) infection. Japan is the most endemic country for HTLV-1 and ATL in the world. Recent nationwide studies of Japanese blood donors reported that HTLV-1 carriers spread from endemic areas to non-endemic areas. Therefore, the latest information on nationwide epidemiological and clinical data for ATL is necessary to guide clinical practice. We conducted a multicenter, hospital-based survey of newly diagnosed ATL patients from 2010 to 2011...
September 14, 2017: Cancer Science
https://www.readbyqxmd.com/read/28893939/human-t-cell-leukaemia-virus-type-1-parasitism-and-pathogenesis
#3
REVIEW
Charles R M Bangham, Masao Matsuoka
Human T-cell leukaemia virus type 1 (HTLV-1) causes not only adult T-cell leukaemia-lymphoma (ATL), but also inflammatory diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 transmits primarily through cell-to-cell contact, and generates abundant infected cells in the host in order to survive and transmit to a new host. The resulting high proviral load is closely associated with the development of ATL and inflammatory diseases. To increase the number of infected cells, HTLV-1 changes the immunophenotype of infected cells, induces proliferation and inhibits apoptosis through the cooperative actions of two viral genes, tax and HTLV-1 bZIP factor (HBZ)...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28888743/htlv-1-infected-thymic-epithelial-cells-convey-the-virus-to-cd4-t-lymphocytes
#4
Luciana Rodrigues Carvalho Barros, Leandra Linhares-Lacerda, Klaysa Moreira-Ramos, Marcelo Ribeiro-Alves, Maria Cristina Machado Motta, Dumith Chequer Bou-Habib, Wilson Savino
The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4(+)T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells...
August 14, 2017: Immunobiology
https://www.readbyqxmd.com/read/28881635/htlv-1-tax-upregulates-early-growth-response-protein-1-through-nuclear-factor-%C3%AE%C2%BAb-signaling
#5
Qingsong Huang, Zhiguo Niu, Jingxian Han, Xihong Liu, Zhuangwei Lv, Huanhuan Li, Lixiang Yuan, Xiangping Li, Shuming Sun, Hui Wang, Xinxiang Huang
Human T cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that causes adult T cell leukemia (ATL) in susceptible individuals. The HTLV-1-encoded oncoprotein Tax induces persistent activation of the nuclear factor-κB (NF-κB) pathway. Early growth response protein 1 (EGR1) is overexpressed in HTLV-1-infected T cell lines and ATL cells. Here, we showed that both Tax expression and HTLV-1 infection promoted EGR1 overexpression. Loss of the NF-κB binding site in the EGR1 promotor or inhibition of NF-κB activation reduced Tax-induced EGR1 upregulation...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876483/htlv-1-intrafamilial-transmission-among-japanese-immigrants-in-brazil
#6
Larissa M Bandeira, Silvia N O Uehara, Marco A M Puga, Grazielli R Rezende, Ana C P Vicente, João Américo Domingos, Bárbara Vieira do Lago, Christian Niel, Ana Rita Coimbra Motta-Castro
Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The aim of this study was to investigate the intrafamilial transmission of HTLV-1 among Japanese immigrants and their descendants living in a non-endemic area of central Brazil. Six families were investigated. Thirty-seven relatives of the six index cases were tested by ELISA for the presence of anti-HTLV antibodies, and the positive cases were confirmed by Western blot...
September 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28870557/retroviral-envelope-proteins-involvement-in-neuropathogenesis
#7
REVIEW
Dorte Tranberg Hansen, Thor Petersen, Tove Christensen
The primary disease caused by infection with the exogenous human retroviruses, human immunodeficiency virus 1 (HIV-1) or human T-cell lymphotropic virus 1 (HTLV-1), may overlay manifestations of additional autoimmune pathogenesis. Currently, a role for human endogenous retroviruses (HERVs) is also emerging in some autoimmune/immune-mediated diseases, particularly in multiple sclerosis (MS). Both exogenous and endogenous retroviruses have the potential to elicit the processes leading to autoimmune disease. The pathogenicity of the retroviral envelope protein (Env) is a key player with notable importance in neuroimmune diseases...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28866351/human-t-cell-leukemia-virus-type-i-tax-genotype-analysis-in-okinawa-the-southernmost-and-remotest-islands-of-japan-different-distributions-compared-with-mainland-japan-and-the-potential-value-for-the-prognosis-of-aggressive-adult-t-cell-leukemia-lymphoma
#8
Shugo Sakihama, Mineki Saito, Megumi Kuba-Miyara, Takeaki Tomoyose, Naoya Taira, Takashi Miyagi, Masaki Hayashi, Shigeko Kinjo, Sawako Nakachi, Iori Tedokon, Yukiko Nishi, Keita Tamaki, Kazuho Morichika, Jun-Nosuke Uchihara, Satoko Morishima, Ken-Nosuke Karube, Yuetsu Tanaka, Hiroaki Masuzaki, Takuya Fukushima
Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB cases-differed from that of a previous report from Kagoshima Prefecture in mainland Japan (taxA, 10%; taxB, 90%)...
August 18, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28836703/anoikis-resistance-and-oncoviruses
#9
Ehsan Kakavandi, Ramin Shahbahrami, Hossein Goudarzi, Gita Eslami, Ebrahim Faghihloo
Anoikis is known as a special type of programmed cell death which occurs in response to loss of correct cell-extracellular matrix (ECM) connections. This process could be as pivotal event in normal development and tissue homeostasis and found as important mechanism in cancer invasiveness and metastasis. The persistent infection with oncoviruses including EBV (Epstein Bar virus), HPV (Human Papillomaviruses), HBV (Hepatitis B virus), KSHV (Human herpesvirus 8), HTLV-1 (Human T-lymphotropic virus-1), and HCV (Hepatitis C virus) accounted as one of main risk factor for cancer progression...
August 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28833639/expression-and-significance-of-pim-3-kinase-in-adult-t-cell-leukemia
#10
Chie Ishikawa, Masachika Senba, Tadashi Hashimoto, Atsushi Imaizumi, Naoki Mori
BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). Viral Tax protein plays a major role in ATL development. Pim family of serine/threonine kinases is composed of Pim-1, -2, and -3. The potential of Pim family as a target in ATL was analyzed. METHODS: RT-PCR and Western blotting were used to determine the expression of Pim kinases, Tax, and intracellular signal molecules. Knockdown of Pim-3 and RelA was performed using small interfering RNA...
August 19, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28827086/risk-factors-for-erectile-dysfunction-in-men-with-htlv-1
#11
Cassius José Vitor de Oliveira, José Abraão Carneiro Neto, Rosana C P Andrade, Paulo Novis Rocha, Edgar Marcelino de Carvalho Filho
BACKGROUND: Erectile dysfunction (ED) occurs in more than 50% of patients with human T-cell lymphotropic virus type 1 (HTLV-1) infection. In the general population, atherosclerosis is the main risk factor related to ED. AIM: To compare the contribution of neurologic disorders from HTLV-1 with that of atherosclerosis as risk factors for ED in men with HTLV-1. METHODS: In this cross-sectional study, men 18 to 70 years old with HTLV-1 were classified into one of two groups according to the presence or absence of ED...
August 18, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28822906/the-impact-of-htlv-1-on-the-cellular-genome
#12
REVIEW
Lucy Cook, Anat Melamed, Hiroko Yaguchi, Charles Rm Bangham
Human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T-cell leukaemia/lymphoma (ATL), an aggressive CD4+ T-cell malignancy. The mechanisms of leukaemogenesis in ATL are incompletely understood. Insertional mutagenesis has not previously been thought to contribute to the pathogenesis of ATL. However, the recent discovery that HTLV-1 binds the key chromatin architectural protein CTCF raises the hypothesis that HTLV-1 deregulates host gene expression by causing abnormal chromatin looping, bringing the strong HTLV-1 promoter-enhancer near to host genes that lie up to 2Mb from the integrated provirus...
August 17, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28821586/ku70-senses-htlv-1-dna-and-modulates-htlv-1-replication
#13
Jie Wang, Lixia Kang, Di Song, Lu Liu, Shuai Yang, Lingling Ma, Zhixiang Guo, Huaxia Ding, Hui Wang, Bo Yang
Human T lymphotropic virus type 1 (HTLV-1) belongs to the deltaretrovirus family and has been linked to multiple diseases. However, the innate host defense against HTLV-1 is unclear. In this study, we report that the expression of Ku70, a known DNA sensor against DNA viruses, could be induced by HTLV-1 infection in HeLa, PMA-differentiated THP1 cells, primary human monocytes, and human monocyte-derived macrophages. In these cells, the overexpression of Ku70 inhibited the HTLV-1 protein expression, whereas the knockdown of Ku70 promoted the HTLV-1 protein expression...
August 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28811663/monitoring-molecular-response-in-adult-t-cell-leukemia-by-high-throughput-sequencing-analysis-of-htlv-1-clonality
#14
M Artesi, A Marçais, K Durkin, N Rosewick, V Hahaut, F Suarez, A Trinquand, L Lhermitte, V Asnafi, V Avettand-Fenoel, A Burny, M Georges, O Hermine, A Van den Broeke
No abstract text is available yet for this article.
August 16, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28771137/the-duffy-null-genotype-is-associated-with-a-lower-level-of-ccl2-leukocytes-and-neutrophil-count-but-not-with-the-clinical-outcome-of-htlv-1-infection
#15
Maria Clara Fernandes da Silva-Malta, Camila Campos Sales, Jacqueline Cronemberger Guimarães, Poliane de Cássia Gonçalves, Daniel Gonçalves Chaves, Hadassa Campos Santos, Alexandre da Costa Pereira, João Gabriel Ribas, Anna Bárbara de Freitas Carneiro-Proietti, Marina Lobato Martins
PURPOSE: Chemokines are important in the immune response against viral infections, and may play a role in human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis. Polymorphisms in the Duffy antigen receptor for chemokines (DARC), such as rs12075 (A>G; FY*B>FY*A) and rs281477 (-46T>C; GATA-1 box) may influence circulating concentrations of proinflammatory chemokines. We investigate whether Duffy genotypes influence the HTLV-1 proviral load (PVL) level, HTLV-1 infection outcome and chemokine concentrations in HTLV-1 asymptomatic carriers (AC=162), HAM/TSP patients (HAM=135) and seronegative individuals (SN=71)...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28768861/positive-and-negative-regulation-of-type-i-interferons-by-the-human-t-cell-leukemia-virus-antisense-protein-hbz
#16
Manraj Singh Narulla, Ahlam Alsairi, Lucie Charmier, Stephen Noonan, David Conroy, William W Hall, Noreen Sheehy
The pathogenesis of human T-cell leukemia virus type 1 (HTLV-1) is strongly linked to the viral regulatory proteins Tax1 and HBZ, whose opposing functions contribute to the clinical outcome of infection. Type I interferons α and β (IFNα and IFNβ) are key cytokines involved in innate immunity and IFNα, in combination with other antivirals, is extensively used in the treatment of HTLV-1 infection. The relationship between HTLV-1 and IFN signaling is unclear and to date the effect of HBZ on this pathway has not been examined...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28755019/turning-a-blind-eye-htlv-1-associated-uveitis-in-indigenous-adults-from-central-australia
#17
Rusheng Chew, Timothy Henderson, Jaskirat Aujla, Eline Whist, Lloyd Einsiedel
PURPOSE: We describe the first two cases of HTLV-1 associated uveitis to be associated with HTLV-1c subtype infection. METHODS: Case report. RESULTS: Uveitis was demonstrated in two Indigenous Australian men, both of whom had high HTLV-1c proviral loads in peripheral blood. Visual outcomes were poor in each case. CONCLUSION: Clinicians should be aware of HTLV-1c infection as a cause of uveitis in Australia, and HTLV-1 serology should be included in the basic uveitis work-up in HTLV-1-endemic areas...
July 28, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28753950/perturbation-of-human-t-cell-leukemia-virus-type-1-particle-morphology-by-differential-gag-co-packaging
#18
José O Maldonado, Isaac Angert, Sheng Cao, Serkan Berk, Wei Zhang, Joachim D Mueller, Louis M Mansky
Human T-cell leukemia virus type 1 (HTLV-1) is an important cancer-causing human retrovirus that has infected approximately 15 million individuals worldwide. Many aspects of HTLV-1 replication, including virus particle structure and assembly, are poorly understood. Group-specific antigen (Gag) proteins labeled at the carboxy terminus with a fluorophore protein have been used extensively as a surrogate for fluorescence studies of retroviral assembly. How these tags affect Gag stoichiometry and particle morphology has not been reported in detail...
July 19, 2017: Viruses
https://www.readbyqxmd.com/read/28745235/effects-of-ascorbic-acid-on-tax-nf-%C3%AE%C2%BAb-and-mmp-9-in-human-t-cell-lymphotropic-virus-type-1-positive-malignant-t-lymphocytes
#19
Steve Harakeh, Jihane Khalife, Elias Baydoun, Rania Azar, Ahmed Al-Hejin, Elie Barbour, Esam Azhar, Aleksandra Niedzwiecki, Soad Al Jaouni, Mona Diab-Assaf, Mohammad Amjad Kamal, Mathias Rath
BACKGROUND: HTLV-1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia by constitutive activation of nuclear factor kappa B. Ascorbic acid (AA) is an essential nutrient that possess anti-proliferative and pro-apoptotic activity against a number of malignant cell lines. This study delineates the effect of AA on Tax protein expression as well as NF-κB and MMP9 activity in two HTLV-1-positive leukemia cells (HuT-102 and C91-PL). METHODS: The cytotoxic and antiproliferative effect of AA were studied by LDH release and MTT tests respectively...
July 25, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28742148/hijacking-of-the-o-glcnaczyme-complex-by-the-htlv-1-tax-oncoprotein-facilitates-viral-transcription
#20
Damien Groussaud, Mostafa Khair, Armelle I Tollenaere, Laetitia Waast, Mei-Shiue Kuo, Marianne Mangeney, Christophe Martella, Yann Fardini, Solène Coste, Mouloud Souidi, Laurence Benit, Claudine Pique, Tarik Issad
The viral Tax oncoprotein plays a key role in both Human T-cell lymphotropic virus type 1 (HTLV-1)-replication and HTLV-1-associated pathologies, notably adult T-cell leukemia. Tax governs the transcription from the viral 5'LTR, enhancing thereby its own expression, via the recruitment of dimers of phosphorylated CREB to cAMP-response elements located within the U3 region (vCRE). In addition to phosphorylation, CREB is also the target of O-GlcNAcylation, another reversible post-translational modification involved in a wide range of diseases, including cancers...
July 2017: PLoS Pathogens
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