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HTLV-1

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https://www.readbyqxmd.com/read/29149590/just-a-spoonful-of-sugar-htlv-1-style
#1
Naomi Taylor
Host cell metabolism regulates viral infection. In this issue of Cell Chemical Biology, Kulkarni et al. (2017) reveal the importance of oxygen concentrations and glycolysis in the reactivation of human T cell leukemia virus (HTLV-1). Identifying the host metabolic networks that regulate infection will foster our understanding of HTLV-1-associated pathologies.
November 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29147642/recurrent-cystoisospora-belli-in-a-patient-with-htlv-1-infection
#2
Mustafa Hasan, Eliahu Bishburg, Sandhya Nagarakanti
No abstract text is available yet for this article.
2017: IDCases
https://www.readbyqxmd.com/read/29147486/a-novel-medium-throughput-biological-assay-system-for-htlv-1-infectivity-and-drug-discovery
#3
Mojtaba Fattahi Abdizadeh, Manoochehr Makvandi, Alireza Samarbafzadeh, Kayhan Azadmanesh
Objectives: Here, a reporter cell line containing two reporter vectors were developed, in order to monitor the Human T-Lymphotropic Virus type1(HTLV-1) infectivity and the cell viability simultaneously. Materials and Methods: The reporter cell line was constructed by stably transfected baby hamster's kidney cell line (BHK-21), with the genomes expressing two different reporters in separate plasmids. The first reporter gene is transactivated by the HTLV-1 tax protein, while the second reporter is continuously expressed when introduced into a mammalian cell...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29144838/human-t-cell-leukemia-virus-type-1-persistence-and-pathogenesis
#4
Charles R M Bangham
Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related lentivirus HIV-1, HTLV-1 causes disease in only 5-10% of infected people, depending on their ethnic origin. But whereas HIV-1 infection and the consequent diseases can be efficiently contained in most cases by antiretroviral drug treatment, there is no satisfactory treatment for the malignant or inflammatory diseases caused by HTLV-1...
November 16, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/29129607/polymorphisms-in-hla-c-and-kir-alleles-are-not-associated-with-ham-tsp-risk-in-htlv-1-infected-subjects
#5
Tatiane Assone, Fernanda M Malta, Sonia Bakkour, Leilani Montalvo, Arthur M Paiva, Jerusa Smid, Augusto César Penalva de Oliveira, Fernanda de Toledo Gonçalves, Olinda do Carmo Luiz, Luiz Augusto M Fonseca, Philip J Norris, Jorge Casseb
INTRODUCTION: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. METHODS: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases "Emilio Ribas" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016...
November 10, 2017: Virus Research
https://www.readbyqxmd.com/read/29099045/gene-editing-in-human-lymphoid-cells-role-for-donor-dna-type-of-genomic-nuclease-and-cell-selection-method
#6
Anastasia Zotova, Elena Lopatukhina, Alexander Filatov, Musa Khaitov, Dmitriy Mazurov
Programmable endonucleases introduce DNA breaks at specific sites, which are repaired by non-homologous end joining (NHEJ) or homology recombination (HDR). Genome editing in human lymphoid cells is challenging as these difficult-to-transfect cells may also inefficiently repair DNA by HDR. Here, we estimated efficiencies and dynamics of knockout (KO) and knockin (KI) generation in human T and B cell lines depending on repair template, target loci and types of genomic endonucleases. Using zinc finger nuclease (ZFN), we have engineered Jurkat and CEM cells with the 8...
November 2, 2017: Viruses
https://www.readbyqxmd.com/read/29095831/ct-chest-and-pulmonary-functional-changes-in-patients-with-htlv-associated-myelopathy-in-the-eastern-brazilian-amazon
#7
Luiz Fábio Magno Falcão, Aline Semblano Carreira Falcão, Rita Catarina Medeiros Sousa, Waldônio de Brito Vieira, Robson Tadachi Moraes de Oliveira, Valéria Marques Ferreira Normando, George Alberto da Silva Dias, Marcio Clementino de Souza Santos, Rodrigo Santiago Barbosa Rocha, Gilberto Toshimitsu Yoshikawa, Roberta Vilela Lopes Koyama, Satomi Fujihara, Víctor Augusto Cavaleiro Corrêa, Hellen Thais Fuzii, Juarez Aantônio Simões Quaresma
The aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 2013 and June 2016, we included 48 patients with HAM/TSP (19 women and 11 men) and without HAM/TSP (12 women and 6 men). We compared CT findings and lung functions of these groups. Patients who had HAM/TSP had abnormal CT findings (P = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29094771/indolent-waxing-and-waning-cutaneous-presentation-of-htlv-1-associated-adult-t-cell-leukemia-lymphoma-in-an-hiv-1-positive-patient
#8
Justin D Richey, Benjamin J Chen, April C Deng
It is well known that patients infected with human immunodeficiency virus type I (HIV-1) are more likely to develop malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma, and anal and cervical carcinomas.
November 2, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29090417/long-term-clinical-remission-maintained-after-cessation-of-zidovudine-and-interferon-%C3%AE-therapy-in-chronic-adult-t-cell-leukemia-lymphoma
#9
Lucy B Cook, Aileen G Rowan, Maria A Demontis, Sophie Sagawe, Nicolas A Gillet, Anat Melamed, Claire Greiller, Aviva Witkover, Charles R M Bangham, Graham P Taylor
Globally, > 5-10 million people are estimated to be infected with Human T-lymphotropic virus type 1 (HTLV-1), of whom ~ 5% develop adult T-cell leukemia/lymphoma (ATL). Despite advances in chemotherapy, overall survival (OS) has not improved in the 35 years since HTLV-1 was first described. In Europe/USA, combination treatment with zidovudine and interferon-α (ZDV/IFN-α) has substantially changed the management of patients with the leukemic subtypes of ATL (acute or unfavorable chronic ATL) and is under clinical trial evaluation in Japan...
October 31, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29090234/altered-expression-of-cell-cycle-regulators-in-adult-t-cell-leukemia-lymphoma-patients
#10
Reza Torshizi, Ehsan Ghayour Karimani, Kobra Etminani, Mohammad Mehdi Akbarin, Khadijeh Jamialahmadi, Abbas Shirdel, Hossein Rahimi, Abolghasem Allahyari, Amin Golabpour, Houshang Rafatpanah
BACKGROUND: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and compare the HTLV-1 proviral load and the gene expression levels of cyclin-dependent kinase-2 (CDK2), CDK4, p53, and retinoblastoma (Rb) in ATLL and carrier groups...
October 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29089548/hla-dmb-restricts-human-t-cell-leukemia-virus-type-1-htlv-1-protein-expression-via-regulation-of-atg7-acetylation
#11
Jie Wang, Di Song, Yanzi Liu, Guangjian Lu, Shuai Yang, Lu Liu, Zhitao Gao, Lingling Ma, Zhixiang Guo, Chenguang Zhang, Hui Wang, Bo Yang
The roles of autophagy in viral infection are complicated. While autophagy has been shown to function in host antiviral defense by eliminating intracellular viruses and regulating adaptive immunity, several viruses have evolved molecular mechanisms to get benefits from it. The deltaretrovirus human T-cell leukemia virus type-1 (HTLV-1) has been reported to profit its replication from enhancing autophagosome accumulation. Here, we reported that HLA-DMB (generally referred to here as DMB), the beta chain of the non-classical MHC-II protein HLA-DM, had strong expression in HTLV-1-transformed T-cell lines and could be induced in Hela, PMA-differentiated THP1 (PMA-THP1) or primary human monocytes by HTLV-1 infection...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29084047/infection-by-htlv-1-is-associated-with-high-levels-of-pro-inflammatory-cytokines-in-hiv-hcv-coinfected-patients
#12
Carlos Brites, Marcos Abrahão, Patrícia Bozza, Eduardo M Netto, André Lyra, Fabianna Bahia
OBJECTIVES: HIV, HCV, and HTLV-1 share the same routes of infection, making coinfection by these viruses a frequent finding in endemic areas. However, there is scarce information on the clinical / immunological consequences of triple infection. Coinfection by HTLV-1 is able to modulate cytokine´s production in HIV patients, but there is no data on the immune response of HIV-HCV-HTLV-1 infected patients METHODS:: we compared the plasma levels of 25 different cytokines in HIV-HCV patients, according to their serostatus to HTLV-1 infection...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29077243/dual-inhibition-of-the-mtorc1-and-mtorc2-signaling-pathways-is-a-promising-therapeutic-target-for-adult-t-cell-leukemia
#13
Takahito Kawata, Kohei Tada, Masayuki Kobayashi, Takashi Sakamoto, Yoko Takiuchi, Fumie Iwai, Maki Sakurada, Masakatsu Hishizawa, Kotaro Shirakawa, Keisuke Shindo, Hironori Sato, Akifumi Takaori-Kondo
ATL has a poor prognosis due to severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Recent integrated-genome analysis has revealed mutations in many genes involved in the T-cell signaling pathway, suggesting that the aberration of this pathway is an important factor in ATL pathogenesis and ATL-cell proliferation. We screened a siRNA library to examine signaling-pathway functionality and found that the PI3K/Akt/mTOR pathway is critical to ATL-cell proliferation...
October 27, 2017: Cancer Science
https://www.readbyqxmd.com/read/29075079/diagnostic-dilemma-in-the-morphological-detection-of-flower-cells-in-lymphomas
#14
Neha Singh, Jatin Gandhi, Narendra Agrawal, Ajit Panaych, Narender Tejwani, Anurag Mehta
"Flower cells" are described typically in HTLV-1 induced adult T cell leukemia. Very few case reports have been published documenting flower cells in B cell lymphomas. We herein present a case of Burkitt lymphoma proven on the basis of immunophenotyping and FISH studies, with "flower cells" morphology.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29074651/full-genome-characterization-of-simian-t-cell-leukemia-virus-type-1-subtype-b-from-a-wild-born-captive-gorilla-gorilla-gorilla-with-t-cell-lymphoma
#15
Ahidjo Ayouba, Annelies Michem, Martine Peeters, Francis Vercammen
There are four lineages of primate T-cell lymphocytic viruses (human T-cell lymphocytic virus [HTLV]/simian T-cell lymphocytic virus [STLV]), which are further divided into subtypes. To date, there is only one full-length HTLV-1 subtype b genome available. Here, we report the genome of a new STLV-1 subtype b from a 43-year-old male gorilla with T-cell lymphoma.
October 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29068084/regional-incidences-of-adult-t-cell-leukemia-lymphoma-with-cutaneous-involvement-in-japan
#16
Toshihisa Hamada, Hayato Nomura, Keiji Iwatsuki
Between 2008 and 2015, 462 newly-diagnosed adult T-cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). The 391 patients comprised 193 (50%) with smoldering type, 52 (13%) with chronic type, 44 (11%) with lymphoma type and 102 (26%) with acute type...
October 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29067784/interpretation-of-low-reactivity-in-the-abbott-architect-rhtlv-i-ii-assay
#17
J H C Tosswill, G P Taylor
OBJECTIVE: The objective of this study is to reduce donor tissue wastage. AIM: The aim of this study is to determine, in the case of the Abbott Architect rHTLV I/II assay, whether a signal/cut-off (S/CO) ratio higher than the manufacturer's recommendation of 1·0 could be applied to diagnose significant HTLV-1 seroreactivity. BACKGROUND: The detection of human T cell leukaemia virus type 1 (HTLV-1) infection is primarily based on serology often utilising random access platforms...
October 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29062917/single-cell-heterogeneity-and-cell-cycle-related-viral-gene-bursts-in-the-human-leukaemia-virus-htlv-1
#18
Martin R Billman, David Rueda, Charles R M Bangham
Background: The human leukaemia virus HTLV-1 expresses essential accessory genes that manipulate the expression, splicing and transport of viral mRNAs.  Two of these genes, tax and hbz, also promote proliferation of the infected cell, and both genes are thought to contribute to oncogenesis in adult T-cell leukaemia/lymphoma.  The regulation of HTLV-1 proviral latency is not understood.  tax, on the proviral plus strand, is usually silent in freshly-isolated cells, whereas the minus-strand-encoded hbz gene is persistently expressed at a low level...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29052136/human-t-cell-leukemia-virus-type-1-infection-and-adult-t-cell-leukemia
#19
Chi-Ping Chan, Kin-Hang Kok, Dong-Yan Jin
Human T-cell leukemia virus type 1 (HTLV-1) is the first retrovirus discovered to cause adult T-cell leukemia (ATL), a highly aggressive blood cancer. HTLV-1 research in the past 35 years has been most revealing in the mechanisms of viral oncogenesis. HTLV-1 establishes a lifelong persistent infection in CD4(+) T lymphocytes. The infection outcome is governed by host immunity. ATL develops in 2-5% of infected individuals 30-50 years after initial exposure. HTLV-1 encodes two oncoproteins Tax and HBZ, which are required for initiation of cellular transformation and maintenance of cell proliferation, respectively...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29050201/htlv-1-viral-oncogene-hbz-induces-osteolytic-bone-disease-in-transgenic-mice
#20
Alison K Esser, Daniel A Rauch, Jingyu Xiang, John C Harding, Nicole A Kohart, Michael H Ross, Xinming Su, Kevin Wu, Devra Huey, Yalin Xu, Kiran Vij, Patrick L Green, Thomas J Rosol, Stefan Niewiesk, Lee Ratner, Katherine N Weilbaecher
Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy that occurs in HTLV-1 infected patients. Most ATL patients develop osteolytic lesions and hypercalcemia of malignancy, causing severe skeletal related complications and reduced overall survival. The HTLV-1 virus encodes 2 viral oncogenes, Tax and HBZ. Tax, a transcriptional activator, is critical to ATL development, and has been implicated in pathologic osteolysis. HBZ, HTLV-1 basic leucine zipper transcription factor, promotes tumor cell proliferation and disrupts Wnt pathway modulators; however, its role in ATL induced osteolytic bone loss is unknown...
September 19, 2017: Oncotarget
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