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https://www.readbyqxmd.com/read/28215175/cd4-t-cell-count-may-not-be-a-useful-strategy-to-monitor-antiretroviral-therapy-response-in-htlv-1-hiv-co-infected-patients
#1
Alain Vandormael, Filipe Rego, Siva Danaviah, Luiz Alcantara, David Boulware, Tulio de Oliveira
BACKGROUND: HTLV-1/HIV co-infection is known to elevate the CD4+ T-cell counts of treatment-naïve persons. We investigated whether HTLV-1/HIV co-infected patients continued to have elevated CD4+ T-cell counts after developing virologic failure on antiretroviral therapy (ART). METHODS: The data comes from a drug resistance study located in the KwaZulu-Natal province of South Africa. All participants (N=383) presented for repeated CD4+ T-cell count and HIV viral load level testing between January 2006 and March 2014...
February 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28212879/flow-cytometric-based-protocols-for-assessing-anti-mt-2-igg1-reactivity-high-dimensional-data-handling-to-define-predictors-for-clinical-follow-up-of-human-t-cell-leukemia-virus-type-1-infection
#2
Jordana Grazziela Coelho-Dos-Reis, Vanessa Peruhype-Magalhães, Marcelo Antônio Pascoal-Xavier, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ludmila Melo Cardoso, Juan Jonathan-Gonçalves, Ágata Lopes Ribeiro, Ana Lúcia Borges Starling, João Gabriel Ribas, Denise Utsch Gonçalves, Anna Bárbara de Freitas Carneiro-Proietti, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho
The present work provides an innovative methodological approach to assess the anti-HTLV-1 IgG1 reactivity with practical application in clinical laboratory. Serum from non-infected healthy controls (NI) and HTLV-1-infected patients, categorized as asymptomatic (AS), putatively progressing to HTLV-1 associated myelopathy/tropical spastic paraparesis - HAM/TSP (pHAM) or with clinical diagnosis of HAM/TSP (HT) were assayed in two-parallel flow cytometry platforms, referred as: Fix and Fix&Perm protocols. Operating-characteristics analysis indicated that a single pair of attributes ("serum dilution/cut-off") for Fix and Fix&Perm protocols presented excellent performance for the diagnosis of HTLV-1 infection...
February 14, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28210503/strongyloidiasis-current-status-with-emphasis-in-diagnosis-and-drug-research
#3
REVIEW
Tiago Mendes, Karen Minori, Marlene Ueta, Danilo Ciccone Miguel, Silmara Marques Allegretti
Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28206670/altered-expression-of-cxcr3-and-ccr6-and-their-ligands-in-htlv-1-carriers-and-ham-tsp-patients
#4
Houshang Rafatpanah, Mehdi Felegari, Mahmoud Reza Azarpazhooh, Rosita Vakili, Taraneh Rajaei, Ian Hampson, Golmahossein Hassanshahi, Narges Valizadeh, Sina Gerayli, Hamid Farjifard, Shadi Zamanian, Farzad MollaHosseini, Seyed Abdolrahim Rezaee
Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were measured in HAM/TSP patients, HTLV-1 asymptomatic carriers (ACs), and healthy controls. The PVL, CCR6 and CXCR3 mRNA expression, and CXCL9 and CXCL10 protein levels were measured in all subjects...
February 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28204810/htlv-1-basic-leucine-zipper-factor-downregulates-cyclin%C3%A2-d1-expression-via-interactions-with-nf-%C3%AE%C2%BAb
#5
Yunyun Ma, Bo Zhang, Dong Wang, Lili Qian, Xianmei Song, Xueyin Wang, Chaokuan Yang, Guoqiang Zhao
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the provirus, is expressed in all cases of ATL and involved in T cell proliferation. However, the exact mechanism underlying its growth-promoting activity is poorly understood. Herein, we demonstrated that HBZ suppressed cyclin D1 expression by inhibiting the nuclear factor (NF)-κB signaling pathway...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28202003/prevalence-and-risk-factors-for-human-t-lymphotropic-virus-type-1-htlv-1-among-maintenance-hemodialysis-patients
#6
Rilma F S Santos, Gildásio C Conceição, Márcia S Martins, Angiolina Kraychete, Maria A C Penalva, Edgar M Carvalho, Antonio Alberto Lopes, Paulo Novis Rocha
BACKGROUND: Infection with the human T-cell lymphotropic virus type 1 (HTLV-1), although asymptomatic in most cases, can lead to potentially grave consequences, such as adult T-cell leukemia-lymphoma and HTLV-1-associated myelopathy / tropical spastic paraparesis. Its prevalence varies widely across different populations and geographic regions. A population-based study in the city of Salvador, located in the Northeast region of Brazil, showed an overall prevalence of HTLV-1 seropositivity of 1...
February 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28193549/identification-of-rare-hiv-1-group-n-hbv-ae-and-htlv-3-strains-in-rural-south-cameroon
#7
M A Rodgers, A S Vallari, B Harris, J Yamaguchi, V Holzmayer, K Forberg, M G Berg, J Kenmenge, C Ngansop, B Awazi, D Mbanya, L Kaptue, C Brennan, G Cloherty, N Ndembi
Surveillance of emerging viral variants is critical to ensuring that blood screening and diagnostic tests detect all infections regardless of strain or geographic location. In this study, we conducted serological and molecular surveillance to monitor the prevalence and diversity of HIV, HBV, and HTLV in South Cameroon. The prevalence of HIV was 8.53%, HBV was 10.45%, and HTLV was 1.04% amongst study participants. Molecular characterization of 555 HIV-1 specimens identified incredible diversity, including 7 subtypes, 12 CRFs, 6 unclassified, 24 Group O and 2 Group N infections...
February 10, 2017: Virology
https://www.readbyqxmd.com/read/28185943/hepatitis-c-virus-hcv-and-human-t-cell-lymphotropic-virus-type-1-htlv-1-coinfection-impact-on-liver-disease-virological-markers-and-neurological-outcome
#8
Otávio M Espíndola, Alexandre G Vizzoni, Elisabeth Lampe, Maria José Andrada-Serpa, Abelardo Q C Araújo, Ana Claudia C Leite
OBJECTIVES: HTLV-1 infection is associated with neurological abnormalities, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and peripheral neuropathy (PN). HCV infection is the leading cause of chronic liver disease worldwide, and causes PN in approximately 9% of patients. Because the interplay between these potentially neuropathogenic viruses in a same individual is still poorly understood we evaluated clinical and laboratory outcomes in coinfected patients and compared them with controls...
February 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28185411/htlv-1-seroprevalance-in-sarcoidosis-a-clinical-and-laboratory-study-in-northeast-of-iran
#9
Massoud Saghafi, Zahra Rezaieyazdi, Shima Nabavi, Zahra Mirfeizi, Maryam Sahebari, Masoumeh Salari
AIM: Sarcoidosis is an autoimmune multiorgan granulomatosis disease with unknown origin. Some environmental factors such as viruses may induce the disease in genetically susceptible individuals. Human T cell lymphotropic virus type 1 (HTLV-1) can dysregulate the human immune system and the role of this virus in the pathogenesis of autoimmune diseases has been investigated and documented, such as in uveitis. In this study, we have focused on the seroprevalence of HTLV-1 in sarcoidosis in comparison to the normal population in the northeast of Iran, an endemic area for HTLV-1...
February 9, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28182361/evaluation-of-line-immunoassay-to-detect-htlv-1-infection-in-an-endemic-area-southwestern-japan-comparison-with-polymerase-chain-reaction-and-western-blot
#10
Kazumi Umeki, Kunihiko Umekita, Yuuki Hashikura, Ikuo Yamamoto, Kazuyoshi Kubo, Yasuhiro Nagatomo, Akihiko Okayama
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) has been recognized as a cause of adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis, and HTLV-1-associated uveitis. HTLV-1 infection is normally detected by screening for HTLV-1 antibodies, and positive samples are confirmed by Western blot (WB). However, WB fails to confirm some samples that were positive for HTLV-1 antibodies on screening. Line immunoassay (LIA) is commonly used in Europe and Brazil, but not in Japan...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28178905/adult-t-cell-leukemia-lymphoma-in-south-and-central-america-and-the-caribbean-systematic-search-and-review
#11
Pedro D Oliveira, Rebeca F de Carvalho, Achiléa L Bittencourt
Adult T-cell leukemia/lymphoma (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1) which is endemic in countries of Caribbean and Central and South America. We performed a systematic search and review to identify publications on ATL in these countries to verify if this disease was getting recognition in these regions as well as the characteristics of the observed cases. The median age of 49.4 years was lower than that referred to in Japan. According to our findings in most Brazilian states and in some other countries, ATL is not being recognized and should be strongly considered in the differential diagnosis of T-cell leukemias/lymphomas...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28178142/treatment-of-rheumatoid-arthritis-with-biologics-may-exacerbate-htlv-1-associated-conditions-a-case-report
#12
Yukiko Terada, Koju Kamoi, Kyoko Ohno-Matsui, Kazunori Miyata, Chinami Yamano, Ariella Coler-Reilly, Yoshihisa Yamano
RATIONALE: There are roughly 5 to 10 million persons infected with human T-lymphotropic virus type 1 (HTLV-1) worldwide, and the safety of treating this population with biologics remains poorly understood. PATIENT CONCERNS AND DIAGNOSIS: An HTLV-1-infected 66-year-old female with HTLV-1 uveitis (HU) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Her HU had been in remission and her HAM/TSP symptoms had been managed effectively with oral steroids for years...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28158226/htlv-1-is-predominantly-sexually-transmitted-in-salvador-the-city-with-the-highest-htlv-1-prevalence-in-brazil
#13
David Nunes, Ney Boa-Sorte, Maria Fernanda Rios Grassi, Graham P Taylor, Maria Gloria Teixeira, Mauricio L Barreto, Inês Dourado, Bernardo Galvão-Castro
BACKGROUND: Salvador is the city with the highest number of HTLV-1 infected individuals in Brazil, yet the main route of HTLV-1 transmission is unknown. OBJECTIVE: To investigate the association of syphilis infection as a proxy for sexual transmission of HTLV-1 infection in the general population of this city. METHODS: A cross sectional population-based study was conducted with 3,451 serum samples obtained by a representative simple random sampling...
2017: PloS One
https://www.readbyqxmd.com/read/28152383/htlv-1-tax-activates-hiv-1-transcription-in-latency-models
#14
Victor Emmanuel Viana Geddes, Diego Pandeló José, Fabio E Leal, Douglas F Nixon, Amilcar Tanuri, Renato Santana Aguiar
HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription. Here, we demonstrate that Tax activates HIV transcription in latent CD4(+) T cells. Tax promotes the activation of P-TEFb, releasing CDK9 and Cyclin T1 from inactive forms, promoting transcription elongation and reactivation of latent HIV-1. Tax mutants lacking interaction with the HIV-1-LTR promoter were not able to activate P-TEFb, with no subsequent activation of latent HIV...
January 30, 2017: Virology
https://www.readbyqxmd.com/read/28150581/a-novel-mother-to-child-htlv-1-transmission-model-for-investigating-the-role-of-maternal-anti-htlv-1-antibodies-using-orally-infected-mother-rats
#15
Yuji Murakami, Atsuhiko Hasegawa, Satomi Ando, Reiko Tanaka, Takao Masuda, Yuetsu Tanaka, Mari Kannagi
Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that is a causative agent of adult T-cell leukemia/lymphoma (ATL) and mainly transmitted from an infected mother to her child via breastfeeding. Such an HTLV-1 infection during childhood is believed to be a risk factor for ATL development. Although it has been suggested that an increased proviral load (PVL), a higher titer of antibody (Ab) in the infected mother, and prolonged breastfeeding are associated with an increased risk of mother-to-child transmission (MTCT), the mechanisms underlying MTCT of HTLV-1 remain largely unknown...
February 1, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28138863/persistent-risk-of-adult-t-cell-leukemia-lymphoma-after-neonatal-htlv-1-infection-through-exchange-transfusion
#16
Eric Oksenhendler, Jocelyn Turpin, Raphael Lhote, Olivier Cassar, Jean-Michel Cayuela, Claire Fieschi, Lionel Galicier, Veronique Meignin, Charles Bangham, Antoine Gessain
A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.
January 30, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28137274/seroprevalence-and-geographical-distribution-of-human-t-lymphotropic-virus-type-1-among-volunteer-blood-donors-in-endemic-areas-of-iran
#17
Gharib Karimi, Maryam Zadsar, Ali Akbar Pourfathollah
BACKGROUND: Human T-cell lymphotrophic virus type 1 (HTLV-1) has a worldwide distribution and it is endemic in some regions of Iran. One of the most important routes of HTLV-1 transmission is via transfusion of contaminated blood components. The risk of transmission through asymptomatic blood donors, particularly in endemic areas should be considered and appropriately managed. The main objective of this study was to determine the seroprevalence and description the geographic distribution of HTLV-1 among voluntary blood donors in Iran...
January 30, 2017: Virology Journal
https://www.readbyqxmd.com/read/28137248/multidisciplinary-insight-into-clonal-expansion-of-htlv-1-infected-cells-in-adult-t-cell-leukemia-via-modeling-by-deterministic-finite-automata-coupled-with-high-throughput-sequencing
#18
Amir Farmanbar, Sanaz Firouzi, Sung-Joon Park, Kenta Nakai, Kaoru Uchimaru, Toshiki Watanabe
BACKGROUND: Clonal expansion of leukemic cells leads to onset of adult T-cell leukemia (ATL), an aggressive lymphoid malignancy with a very poor prognosis. Infection with human T-cell leukemia virus type-1 (HTLV-1) is the direct cause of ATL onset, and integration of HTLV-1 into the human genome is essential for clonal expansion of leukemic cells. Therefore, monitoring clonal expansion of HTLV-1-infected cells via isolation of integration sites assists in analyzing infected individuals from early infection to the final stage of ATL development...
January 31, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28119118/htlv-1-tax-impairs-k63-linked-ubiquitination-of-sting-to-evade-host-innate-immunity
#19
Jie Wang, Shuai Yang, Lu Liu, Hui Wang, Bo Yang
The cellular antiviral innate immune system is essential for host defense and viruses have evolved a variety of strategies to evade the innate immunity. Human T lymphotropic virus type 1 (HTLV-1) belongs to the deltaretrovirus family and it can establish persistent infection in human beings for many years. However, how this virus evades the host innate immune responses remains unclear. Here we report a new strategy used by HTLV-1 to block innate immune responses. We observed that stimulator of interferon genes (STING) limited HTLV-1 protein expression and was critical to HTLV-1 reverse transcription intermediate (RTI) ssDNA90 triggered interferon (IFN)-β production in phorbol12-myristate13-acetate (PMA)-differentiated THP1 (PMA-THP1) cells...
January 22, 2017: Virus Research
https://www.readbyqxmd.com/read/28115366/adult-t-cell-leukemia-atl-molecular-basis-for-clonal-expansion-and-transformation-of-htlv-1-infected-t-cells
#20
Toshiki Watanabe
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process involving five or more genetic events. In this review, we provided a comprehensive overview of recently uncovered information on the molecular basis of leukemogenesis in ATL. Broadly, the landscape of genetic abnormalities in ATL that include alterations highly enriched in genes for T cell receptor-NF-κB signaling such as PLCG1, PRKCB, and CARD11 and gain-of function mutations in CCR4 and CCR7 Conversely, the epigenetic landscape of ATL can be summarized as polycomb repressive complex 2 (PRC2) hyperactivation with genome-wide H3K27 me3 accumulation as the basis of the unique transcriptome of ATL cells...
January 23, 2017: Blood
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