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https://www.readbyqxmd.com/read/28315754/hepatitis-b-and-htlv-1-co-infection-in-the-northern-territory-australia
#1
Ian Marr, Jane Davies, Rob W Baird
OBJECTIVE: To establish the relationship of Hepatitis B and HTLV-1 serological markers in the Northern Territory, Australia. METHODS: A retrospective serological study of patients, presenting to public healthcare facilities, in the Northern Territory between 2008 and 2015, was performed to determine presence and relationships of serological markers of Hepatitis B virus (HBV), and Human T-cell Leukemic virus 1 (HTLV-1). RESULTS: There were 740 individual cases of serological positive HTLV-1 identified over 8 years in the Northern Territory...
March 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28298599/bushmeat-hunting-and-zoonotic-transmission-of-simian-t-lymphotropic-virus-1-in-tropical-west-and-central-africa
#2
Arsène Mossoun, Sébastien Calvignac-Spencer, Augustin E Anoh, Maude S Pauly, Daniel A Driscoll, Adam O Michel, Lavry Grah Nazaire, Stefan Pfister, Pascale Sabwe, Ulla Thiesen, Barbara R Vogler, Lidewij Wiersma, Jean-Jacques Muyembe-Tamfum, Stomy Karhemere, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Barbara Fruth, Roman M Wittig, Fabian H Leendertz, Grit Schubert
Simian T-lymphotropic virus 1 (STLV-1) enters human populations through contact with non-human primate (NHP) bushmeat. We tested whether differences in the extent of contact to STLV-1 infected NHP bushmeat foster regional differences in prevalence of human HTLV-1. Using serological and PCR assays, we screened humans and NHP at two sub-Saharan African sites where subsistence hunting was expected to be less (Taï region, Côte d'Ivoire, CIV) or more developed (Bandundu region, Democratic Republic of the Congo, DRC)...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28295186/skin-lesions-and-cytological-features-in-htlv-1-associated-adult-t-cell-leukaemia-lymphoma
#3
Juan Marquet, Miguel Piris-Villaespesa, Eulalia Rodriguez, Sandra López, Jesús Villarrubia, Jose Antonio García-Vela
No abstract text is available yet for this article.
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28293169/brain-metabolism-changes-in-patients-infected-with-htlv-1
#4
Manuel Schütze, Luiz C F Romanelli, Daniela V Rosa, Anna B F Carneiro-Proietti, Rodrigo Nicolato, Marco A Romano-Silva, Michael Brammer, Débora M de Miranda
The Human T-cell leukemia virus type-I (HTLV-1) is the causal agent of HTLV-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP). HAM/TSP is the result of demyelination and cell death in the spinal cord and disruption of the blood-brain barrier (BBB), mediated by a virus-induced inflammatory response. In this study, we applied Positron Emission Tomography with 18F-fluordeoxyglucose (18F-FDG PET) to evaluate brain metabolism in a group of 47 patients infected with HTLV-1, and 18 healthy controls. Patients were divided into three groups according to their neurological symptoms...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28282508/cardiovascular-risk-profile-in-patients-with-myelopathy-associated-with-htlv-1
#5
Fabio Luís Silva do Prado, Renata Prado de Fuccio Oliveira, Ana Marice Teixeira Ladeia
HAM/TSP (HTLV-1-associated myelopathy/tropical spastic paraparesis) is a slowly progressive disease, characterized by a chronic spastic paraparesis. It is not known if the disease carries an independent risk for cardiovascular disease. The objective of this study was to evaluate the cardiovascular risk profile related to HAM/TSP and compare it with the general population. METHODS: This was a cross-sectional study, with a control group. HAM/TSP patients were evaluated using cardiovascular risk scores (ASCVD RISK, SCORE and Framingham) and inflammatory markers (ultrasensitive CRP and IL-6), and compared with a control group of healthy individuals...
March 7, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28282487/establishment-of-multiplex-solid-phase-strip-pcr-test-for-detection-of-24-ocular-infectious-disease-pathogens
#6
Satoko Nakano, Sunao Sugita, Yasuhiro Tomaru, Ayumi Hono, Takako Nakamuro, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Masayo Takahashi, Norio Shimizu
Purpose: To establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip PCR) for concurrent detection of common ocular infectious disease pathogens. Methods: A new multiplex strip PCR was established to detect 24 common ocular infectious disease pathogens: herpes simplex virus (HSV) 1, HSV2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus (HHV) 6, HHV7, HHV8, human T-cell lymphotropic virus (HTLV)-1, adenovirus, Mycobacterium tuberculosis, Treponema pallidum, Propionibacterium acnes (P...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28269998/htlv-infection-in-hcv-antibody-positive-patients-in-spain
#7
Ana Treviño, Antonio Aguilera, Manuel A Rodríguez-Iglesias, Araceli Hernandez, Rafael Benito, Lourdes Roc, José Manuel Ramos, Raúl Ortíz de Lejarazu, Eva Poveda, Carmen Rodríguez, Jorge Del Romero, Enrique Calderon, Juan García, Silvia Requena, Vincent Soriano, Carmen de Mendoza
Since hepatitis C virus (HCV) and human T-lymphotropic virus (HTLV) share transmission routes, dual infection could be frequent. In Spain, HTLV underdiagnosis is highlighted by the high proportion of patients presenting either with tropical spastic paraparesis (TSP) or adult T-cell leukemia (ATL) at first diagnosis. We examined whether the renewed efforts for expanding HCV testing may provide a sentinel population that might selectively be targeted to unveil asymptomatic HTLV carriers. The presence of anti-HTLV antibodies was examined in 3,838 consecutive individuals with reactive HCV serology attended during the last three years at 13 hospitals distributed across the Spanish geography...
March 7, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28263674/human-t-cell-leukemia-virus-type-1-and-eye-diseases
#8
Yukiko Terada, Koju Kamoi, Takashi Komizo, Kazunori Miyata, Manabu Mochizuki
Human T cell leukemia virus type 1, also known as human T lymphotropic virus type 1 (HTLV-1), is a retrovirus that encodes a reverse transcriptase, which translates viral RNA into a DNA provirus that is integrated into the host genome. The virus was found to be a causative agent of adult T cell leukemia/lymphoma (ATL) in the early 1980s, and was also found to cause the neurological disorder tropical spastic paraparesis (TSP)/HTLV-1-associated myelopathy (HAM) and the inflammatory disorder HTLV-1 uveitis in the mid 1980s and early 1990s, respectively...
March 1, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28261958/rate-of-positive-autoimmune-markers-in-human-t-lymphotropic-virus-type-1-carriers-a-case-control-study-from-iran
#9
Sanaz Ahmadi Ghezeldasht, Mohammad Reza Hedayati-Moghaddam, Meysam Habibi, Farzad Mollahosseini, Houshang Rafatpanah, Rahele Miri, MohammadReza Hatef Fard, Maryam Sahebari
AIM: Human T lymphotropic virus type 1 (HTLV-1) infection with high prevalence in the north-east of Iran, particularly in Mashhad, can lead to adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and a variety of autoimmune diseases. The aim of the study was to examine the presence of autoimmune markers in HTLV carries. METHODS: Serum samples were obtained from blood donors in Mashhad, northeastern Iran. One hundred and five HTLV-1 positive (cases) and 104 age- and sex-matched HTLV-1 negative donors (controls) were assessed for presence of serum autoimmune markers by enzyme-linked immunosorbent assay...
March 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28261198/a-fas-hi-lymphoproliferative-phenotype-reveals-non-apoptotic-fas-signaling-in-htlv-1-associated-neuroinflammation
#10
Soraya Maria Menezes, Fabio E Leal, Tim Dierckx, Ricardo Khouri, Daniele Decanine, Gilvaneia Silva-Santos, Saul V Schnitman, Ramon Kruschewsky, Giovanni López, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Douglas F Nixon, Jurgen Vercauteren, David Brassat, Roland Liblau, Anne Mieke Vandamme, Bernardo Galvão-Castro, Johan Van Weyenbergh
Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been associated to both ATL and HAM/TSP susceptibility. Fas(hi) T stem cell memory (Tscm) cells have been identified as the hierarchical apex of ATL, but have not been investigated in HAM/TSP...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28260789/hbz-mediated-shift-of-jund-from-growth-suppressor-to-tumor-promoter-in-leukemic-cells-by-inhibition-of-ribosomal-protein-s25-expression
#11
M Terol, H Gazon, I Lemasson, M Duc Dodon, B Barbeau, R Césaire, J-M Mesnard, J-M Péloponèse
HTLV-1 bZIP factor (HBZ) is a key player in proliferation and transformation of HTLV-1-infected cells, thus contributing to ATL development. HBZ deregulates gene expression within the host cell by interacting with several cellular partners. Through its C-terminal ZIP domain, HBZ is able to contact and activate JunD, a transcription factor of the AP-1 family. jund mRNA is intronless but can generate two protein isoforms by alternative translation initiation: JunD full-length and ΔJunD, an N-terminal truncated form unresponsive to the tumor suppressor menin...
March 6, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28256531/repression-of-human-t-lymphotropic-virus-type-1-long-terminal-repeat-sense-transcription-by-sp1-recruitment-to-novel-sp1-binding-sites
#12
Sylvain Fauquenoy, Gwenaëlle Robette, Anna Kula, Caroline Vanhulle, Sophie Bouchat, Nadège Delacourt, Anthony Rodari, Céline Marban, Christian Schwartz, Arsène Burny, Olivier Rohr, Benoit Van Driessche, Carine Van Lint
Human T-lymphotropic Virus type 1 (HTLV-1) infection is characterized by viral latency in the majority of infected cells and by the absence of viremia. These features are thought to be due to the repression of viral sense transcription in vivo. Here, our in silico analysis of the HTLV-1 Long Terminal Repeat (LTR) promoter nucleotide sequence revealed, in addition to the four Sp1 binding sites previously identified, the presence of two additional potential Sp1 sites within the R region. We demonstrated that the Sp1 and Sp3 transcription factors bound in vitro to these two sites and compared the binding affinity for Sp1 of all six different HTLV-1 Sp1 sites...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28252206/analysis-of-htlv-1-proviral-load-pvl-and-antibody-detected-with-various-kinds-of-tests-in-japanese-blood-donors-to-understand-the-relationship-between-pvl-and-antibody-level-and-to-gain-insights-towards-better-antibody-testing
#13
Chieko Matsumoto, Yasuko Sagara, Rieko Sobata, Yukiko Inoue, Maiko Morita, Shigeharu Uchida, Hiroyuki Kiyokawa, Masahiro Satake, Kenji Tadokoro
Adult T-cell leukemia/lymphoma (ATL) occurs in approximately 5% of individuals infected with human T-cell leukemia virus type 1 (HTLV-1). A high proviral load (PVL; more than 4 copies per 100 peripheral blood mononuclear cells (PBMCs) or 1.6 copies per 100 blood leukocytes) and being male are risk factors for ATL development. Whether anti-HTLV-1 antibody level is related to such risk is unknown. Here, PVL and antibody levels were examined using real-time PCR and other tests in 600 HTLV-1 positive screened Japanese blood donors to understand the relationship between PVL and antibody level in asymptomatic carriers and to gain insights towards better antibody testing for HTLV-1 infection...
March 2, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28251608/adult-t-cell-leukemia-lymphoma-in-a-peruvian-hospital-in-human-t-lymphotropic-virus-type-1-htlv-1-positive-patients
#14
Milton José Max Rodríguez-Zúñiga, Florencio Cortez-Franco, Eberth Qujiano-Gomero
BACKGROUND: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive neoplasm of T-lymphocytes associated with human T-lymphotropic virus type I (HTLV-1) infection. As HTLV-1 is endemic in native ethnics in South America, and its infection leads to several chronic diseases as ATLL with poor prognosis, we aimed to present three ATLL cases and to review current literature. CASE REPORTS: Two cases were from the mountains of Peru, while one was from an endemic harbor of the country...
March 2, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28243804/erratum-to-evaluation-of-inos-icam-1-and-vcam-1-gene-expression-a-study-of-adult-t-cell-leukemia-malignancy-associated-with-htlv-1
#15
Mahdokht Jafarian, Sayed-Hamidreza Mozhgani, Elham Patrad, Hamidreza Vaziri, Seyed Abdolrahim Rezaee, Mohammad Mehdi Akbarin, Mehdi Norouzi
No abstract text is available yet for this article.
April 2017: Archives of Virology
https://www.readbyqxmd.com/read/28240367/first-description-of-htlv-1-2-seroprevalence-in-hiv-infected-inmates-in-mozambique
#16
Ângelo Augusto, Orvalho Augusto, Atija Taquimo, Carina Nhachigule, Narcisa Siyawadya, Nelson Tembe, Nilesh Bhatt, Francisco Mbofana, Eduardo Samo Gudo
No study has yet been conducted to estimate the burden of co-infection of HIV and HTLV-1/2 in inmates in sub-Saharan Africa. To investigate prevalence of co-infection in inmates in Mozambique, a total of 2140 inmates were screened for HIV, of which 515 were HIV seropositive. All HIV seropositive inmates were further screened for HTLV infection, and 8 (1.55%) were co-infected. Co-infection was higher in females [3.45% (2/58; CI: 0.42-11.91)] as compared to males [1.35% (6/445; CI: 0.55-3.06)]. Early screening of HTLV in prisons is urgently needed in Mozambique in order to improve the care provided to incarcerated individuals, including initiation of ART...
February 27, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28231270/correction-htlv-1-bzip-factor-enhances-t-cell-proliferation-by-impeding-the-suppressive-signaling-of-co-inhibitory-receptors
#17
Haruka Kinosada, Jun-Ichirou Yasunaga, Kazuya Shimura, Paola Miyazato, Chiho Onishi, Tomonori Iyoda, Kayo Inaba, Masao Matsuoka
[This corrects the article DOI: 10.1371/journal.ppat.1006120.].
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28215175/cd4-t-cell-count-may-not-be-a-useful-strategy-to-monitor-antiretroviral-therapy-response-in-htlv-1-hiv-co-infected-patients
#18
Alain Vandormael, Filipe Rego, Siva Danaviah, Luiz Alcantara, David Boulware, Tulio de Oliveira
BACKGROUND: HTLV-1/HIV co-infection is known to elevate the CD4+ T-cell counts of treatment-naïve persons. We investigated whether HTLV-1/HIV co-infected patients continued to have elevated CD4+ T-cell counts after developing virologic failure on antiretroviral therapy (ART). METHODS: The data comes from a drug resistance study located in the KwaZulu-Natal province of South Africa. All participants (N=383) presented for repeated CD4+ T-cell count and HIV viral load level testing between January 2006 and March 2014...
February 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28212879/flow-cytometric-based-protocols-for-assessing-anti-mt-2-igg1-reactivity-high-dimensional-data-handling-to-define-predictors-for-clinical-follow-up-of-human-t-cell-leukemia-virus-type-1-infection
#19
Jordana Grazziela Coelho-Dos-Reis, Vanessa Peruhype-Magalhães, Marcelo Antônio Pascoal-Xavier, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ludmila Melo Cardoso, Juan Jonathan-Gonçalves, Ágata Lopes Ribeiro, Ana Lúcia Borges Starling, João Gabriel Ribas, Denise Utsch Gonçalves, Anna Bárbara de Freitas Carneiro-Proietti, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho
The present work provides an innovative methodological approach to assess the anti-HTLV-1 IgG1 reactivity with practical application in clinical laboratory. Serum from non-infected healthy controls (NI) and HTLV-1-infected patients, categorized as asymptomatic (AS), putatively progressing to HTLV-1 associated myelopathy/tropical spastic paraparesis - HAM/TSP (pHAM) or with clinical diagnosis of HAM/TSP (HT) were assayed in two-parallel flow cytometry platforms, referred as: Fix and Fix&Perm protocols. Operating-characteristics analysis indicated that a single pair of attributes ("serum dilution/cut-off") for Fix and Fix&Perm protocols presented excellent performance for the diagnosis of HTLV-1 infection...
February 16, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28210503/strongyloidiasis-current-status-with-emphasis-in-diagnosis-and-drug-research
#20
REVIEW
Tiago Mendes, Karen Minori, Marlene Ueta, Danilo Ciccone Miguel, Silmara Marques Allegretti
Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives...
2017: Journal of Parasitology Research
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