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https://www.readbyqxmd.com/read/29780367/expression-of-mir-34a-in-t-cells-infected-by-human-t-lymphotropic-virus-1
#1
Varun K Sharma, Vittoria Raimondi, Katia Ruggero, Cynthia A Pise-Masison, Ilaria Cavallari, Micol Silic-Benussi, Vincenzo Ciminale, Donna M D'Agostino
Human T-lymphotropic virus 1 (HTLV-1) immortalizes T-cells and is the causative agent of adult T-cell leukemia/lymphoma (ATLL). HTLV-1 replication and transformation are governed by multiple interactions between viral regulatory proteins and host cell factors that remain to be fully elucidated. The present study investigated the impact of HTLV-1 infection on the expression of miR-34a, a microRNA whose expression is downregulated in many types of cancer. Results of RT-PCR assays showed that five out of six HTLV-1-positive cell lines expressed higher levels of miR-34a compared to normal PBMC or purified CD4+ T-cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29777913/the-tp53-induced-glycolysis-and-apoptosis-regulator-mediates-cooperation-between-htlv-1-p30-ii-and-the-retroviral-oncoproteins-tax-and-hbz-and-is-highly-expressed-in-an-in-vivo-xenograft-model-of-htlv-1-induced-lymphoma
#2
Tetiana Hutchison, Aditi Malu, Laçin Yapindi, Rachel Bergeson, Kendra Peck, Megan Romeo, Carolyn Harrod, Jordan Pope, Louisa Smitherman, Wesleigh Gwinn, Lee Ratner, Courtney Yates, Robert Harrod
The human T-cell leukemia virus type-1 (HTLV-1) is an oncoretrovirus that infects and transforms CD4+ T-cells and causes adult T-cell leukemia/lymphoma (ATLL) -an aggressive lymphoproliferative disease that is highly refractive to most anticancer therapies. The HTLV-1 proviral genome encodes several regulatory products within a conserved 3' nucleotide sequence, known as pX; however, it remains unclear how these factors might cooperate or dynamically interact in virus-infected cells. Here we demonstrate that the HTLV-1 latency-maintenance factor p30II induces the TP53-induced glycolysis and apoptosis regulator (TIGAR) and counters the oxidative stress, mitochondrial damage, and cytotoxicity caused by the viral oncoproteins Tax and HBZ...
May 16, 2018: Virology
https://www.readbyqxmd.com/read/29773807/risk-factors-associated-with-htlv-1-vertical-transmission-in-brazil-longer-breastfeeding-higher-maternal-proviral-load-and-previous-htlv-1-infected-offspring
#3
Arthur M Paiva, Tatiane Assone, Michel E J Haziot, Jerusa Smid, Luiz Augusto M Fonseca, Olinda do Carmo Luiz, Augusto Cesar Penalva de Oliveira, Jorge Casseb
HTLV-1 is transmitted primarily either through sexual intercourse or from mother to child. The mother/child pairs were classified as seroconcordant or serodiscordant. We analyzed mother to child transmission (MTCT) according to sociodemographic, clinical and epidemiological characteristics of the mother, child's gender and duration of breastfeeding. Between June 2006 and August 2016 we followed 192 mothers with HTLV-1 infection (mean age 41 years old), resulting in 499 exposed offspring, 288 (57.7%) of whom were tested for HTLV-1, making up the final sample for the study, along with their 134 respective mothers...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769340/the-htlv-1-basic-leucine-zipper-factor-hbz-attenuates-repair-of-double-stranded-dna-breaks-via-non-homologous-end-joining-nhej
#4
A W Rushing, K Hoang, N Polakowski, I Lemasson
Adult T-cell leukemia (ATL) is a fatal malignancy of CD4+ T-cells infected with human T-cell leukemia virus type I (HTLV-1). ATL cells often exhibit random gross chromosomal rearrangements that are associated with the induction and improper repair of double-stranded DNA breaks (DSBs). The viral oncoprotein Tax has been reported to impair DSB repair, but is not shown to be consistently expressed throughout all phases of infection. The viral oncoprotein HTLV-1 basic leucine zipper factor (HBZ) is consistently expressed prior to and throughout disease progression, but it is unclear whether it also influences DSB repair...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769062/seroprevalence-of-hiv-htlv-cmv-hbv-and-rubella-virus-infections-in-pregnant-adolescents-who-received-care-in-the-city-of-bel%C3%A3-m-par%C3%A3-northern-brazil
#5
Aubaneide Batista Guerra, Leonardo Quintão Siravenha, Rogério Valois Laurentino, Rosimar Neris Martins Feitosa, Vânia Nakauth Azevedo, Antonio Carlos Rosário Vallinoto, Ricardo Ishak, Luiz Fernando Almeida Machado
BACKGROUND: Prenatal tests are important for prevention of vertical transmission of various infectious agents. The objective of this study was to describe the prevalence of human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), cytomegalovirus (CMV), rubella virus and vaccination coverage against HBV in pregnant adolescents who received care in the city of Belém, Pará, Brazil. METHODS: A cross-sectional study was performed with 324 pregnant adolescents from 2009 to 2010...
May 16, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29768555/the-relationship-between-atopy-and-neurological-manifestations-in-htlv-1-infection
#6
Raquel Crisóstomo Lima Verde, José Abraão Carneiro Neto, Silvane Maria Braga Santos, Edgar Marcelino Carvalho, Marcus Miranda Lessa
INTRODUCTION: Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses. METHODS: Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29744126/htlv-1-atll-refractory-hypercalcaemia-and-hiv-1-co-infection
#7
Abdullah E Laher, Feroza Motara, Muhammed Moolla, Osman Ebrahim
Adult T-cell lymphoma/leukemia (ATLL) is a rare tumour of T-lymphocytes that is associated with human T-lymphotrophic virus type 1 (HTLV-1) infection as well as severe/refractory hypercalcaemia. Human immunodefficiency virus type 1 (HIV-1) infected individuals are at increased risk of acquiring co-infection with HTLV-1. We present the case of a 37 -year -old HIV-1 positive and antiretroviral therapy naive woman who was admitted to the ICU with delirium, a generalised maculopapular rash, severe hypercalcaemia of 4...
January 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29737866/plasma-and-cerebrospinal-fluid-levels-of-cytokines-as-disease-markers-of-neurologic-manifestation-in-long-term-htlv-1-infected-individuals
#8
Daniela V Rosa, Luiz A Magno, Nathália Cm Pereira, Luiz C Romanelli, Maicon R Albuquerque, Marina L Martins, Anna B de Freitas Carneiro Proietti, Rodrigo Nicolato, Ana C Simões E Silva, Debora M de Miranda
AIM: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses. MATERIALS & METHODS: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms. RESULTS: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms...
May 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29733405/phylogeny-of-human-t-lymphotropic-virus-1-subtypes-in-guinea-bissau
#9
Bertram Kjerulff, Bo Langhoff Hønge, Jens Steen Olesen, Mads Mose Jensen, Zacharias Jose da Silva, Christian Erikstrup, Mette Christiansen
Background: Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1) was the first human retrovirus discovered and there is an estimate of 15-20 million infected worldwide. Endemic areas are Japan, West Africa, Central Africa, South America, the Caribbean, Middle East, Australia and the Pacific Islands. In Guinea-Bissau, adult HTLV-1 prevalence is 2-3%, and higher among HIV-infected patients. Materials and methods: Blood samples were collected in a recent HIV/HTLV survey in Bissau, the capital of Guinea-Bissau...
May 4, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29727445/the-htlv-1-gp21-fusion-peptide-inhibits-antigen-specific-t-cell-activation-in-vitro-and-in-mice
#10
Etai Rotem, Omri Faingold, Meital Charni, Yoel A Klug, Daniel Harari, Liraz Shmuel-Galia, Alon Nudelman, Varda Rotter, Yechiel Shai
The ability of the Lentivirus HIV-1 to inhibit T-cell activation by its gp41 fusion protein is well documented, yet limited data exists regarding other viral fusion proteins. HIV-1 utilizes membrane binding region of gp41 to inhibit T-cell receptor (TCR) complex activation. Here we examined whether this T-cell suppression strategy is unique to the HIV-1 gp41. We focused on T-cell modulation by the gp21 fusion peptide (FP) of the Human T-lymphotropic Virus 1 (HTLV-1), a Deltaretrovirus that like HIV infects CD4+ T-cells...
May 4, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29723784/detection-of-htlv-1-proviral-dna-in-bm-mononuclear-cells-and-cultured-mesenchymal-stromal-cells-isolated-from-patients-with-htlv-1-infection
#11
Evandra Strazza Rodrigues, Maria do Carmo Favarin, Mayra Dorigan de Macedo, Katia Kaori Otaguiri, Maristela Delgado Orellana, Osvaldo Massaiti Takayanagui, Patrícia Vianna Bonini Palma, Svetoslav Nanev Slavov, Dimas Tadeu Covas, Simone Kashima
The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4+ T-cell lymphocytes in the BM of HTLV-1-infected individuals was observed when compared to healthy controls. The provirus detection in the BM CD4+ T cells confirmed the presence of integrated HTLV DNA. In regard to MSC, we observed that the number of fibroblast progenitor cells was lower in HTLV-1 infected individuals than in healthy controls...
April 30, 2018: Virology
https://www.readbyqxmd.com/read/29722927/nf-%C3%AE%C2%BAb-signaling-mechanisms-in-htlv-1-induced-adult-t-cell-leukemia-lymphoma
#12
REVIEW
Edward William Harhaj, Chou-Zen Giam
The human T-cell leukemia virus type 1 (HTLV-1) is a complex deltaretrovirus linked to adult T-cell leukemia/lymphoma (ATLL), a fatal CD4+ malignancy in 3-5% of infected individuals. The HTLV-1 Tax regulatory protein plays indispensable roles in regulating viral gene expression and activating cellular signaling pathways that drive the proliferation and clonal expansion of T cells bearing HTLV-1 proviral integrations. Tax is a potent activator of NF-κB, a key signaling pathway that is essential for the survival and proliferation of HTLV-1 infected T cells...
May 3, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29721391/a-genetic-ifn-stat1-fas-axis-determines-cd4-t-stem-cell-memory-levels-and-apoptosis-in-healthy-controls-and-adult-t-cell-leukemia-patients
#13
Ricardo Khouri, Gilvanéia Silva-Santos, Tim Dierckx, Soraya Maria Menezes, Daniele Decanine, Kristof Theys, Aline Clara Silva, Lourdes Farré, Achiléa Bittencourt, Massimo Mangino, Mario Roederer, Anne-Mieke Vandamme, Johan Van Weyenbergh
Adult T-cell leukemia (ATL) is an aggressive, chemotherapy-resistant CD4+ CD25+ leukemia caused by HTLV-1 infection, which usually develops in a minority of patients several decades after infection. IFN + AZT combination therapy has shown clinical benefit in ATL, although its mechanism of action remains unclear. We have previously shown that an IFN-responsive FAS promoter polymorphism in a STAT1 binding site (rs1800682) is associated to ATL susceptibility and survival. Recently, CD4 T stem cell memory (TSCM ) Fashi cells have been identified as the hierarchical cellular apex of ATL, but a possible link between FAS, apoptosis, proliferation and IFN response in ATL has not been studied...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29716616/stability-of-the-htlv-1-glycoprotein-46-gp46-gene-in-an-endemic-region-of-the-brazilian-amazon-and-the-presence-of-a-significant-mutation-n93d-in-symptomatic-patients
#14
Maria de Nazaré do Socorro de Almeida Viana, Akim Felipe Santos Nobre, Edivaldo Costa, Ingrid Christiane Silva, Bruna Teles Pinheiro, Cássia Cristine Costa Pereira, Louise de Souza Canto Ferreira, Danilo Souza de Almeida, Marcos William Leão de Araújo, Mariza da Silva Borges, Carlos Araujo da Costa, Edna Aoba Yassui Ishikawa, Stephen Francis Ferrari, Maísa Silva de Sousa
BACKGROUND: The human T-lymphotropic virus type 1 (HTLV-1) affects 2-5 million people worldwide, and is associated with a number of degenerative and infectious diseases. The Envelope glycoproteins (gp) are highly conserved among the different HTLV-1 isolates, although nucleotide substitutions in the region that codifies these proteins may influence both the infectivity and the replication of the virus. The gp46 gene has functional domains which have been associated with the inhibition of the formation of the syncytium, cell-cell transmission, and the production of antibodies...
May 2, 2018: Virology Journal
https://www.readbyqxmd.com/read/29709026/immunophenotypic-characterization-of-csf-b-cells-in-virus-associated-neuroinflammatory-diseases
#15
Yoshimi Enose-Akahata, Shila Azodi, Bryan R Smith, Bridgette Jeanne Billioux, Ashley Vellucci, Nyater Ngouth, Yuetsu Tanaka, Joan Ohayon, Irene Cortese, Avindra Nath, Steven Jacobson
Intrathecal antibody synthesis is a well-documented phenomenon in infectious neurological diseases as well as in demyelinating diseases, but little is known about the role of B cells in the central nervous systems. We examined B cell and T cell immunophenotypes in CSF of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) compared to healthy normal donors and subjects with the other chronic virus infection and/or neuroinflammatory diseases including HIV infection, multiple sclerosis (MS) and progressive multifocal leukoencephalopathy...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29695435/critical-role-of-the-htlv-1-capsid-n-terminal-domain-for-gag-gag-interactions-and-virus-particle-assembly
#16
Jessica L Martin, Luiza Mendonça, Rachel Marusinec, Jennifer Zuczek, Isaac Angert, Ruth J Blower, Joachim D Mueller, Juan R Perilla, Wei Zhang, Louis M Mansky
The retroviral Gag protein is the main structural protein responsible for virus particle assembly and release. Like human immunodeficiency virus type 1 (HIV-1) Gag, human T-cell leukemia virus type 1 (HTLV-1) has a structurally conserved capsid (CA) domain, including a β-hairpin turn and a centralized coiled-coil-like structure of six α helices in the CA amino-terminal domain (NTD) as well as four α-helices in the CA carboxy-terminal domain (CTD). CA drives Gag oligomerization, which is critical for both immature Gag lattice formation and particle production...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29685460/adult-t-cell-leukemia-lymphoma-review-of-the-literature
#17
M J M Rodríguez-Zúñiga, F Cortez-Franco, E Qujiano-Gomero
Adult T-cell Leukemia/Lymphoma (ATLL) is an aggressive neoplasm of T lymphocytes associated with Human T-lymphotropic virus type1 (HTLV-1) infection. HTLV-1 is a public health problem because it is endemic in native groups in Latin America, and its infection leads to several chronic diseases as ATLL. We aimed to review current literature of ATLL in order to consider it as a differential diagnosis in front of patients with compatible symptoms. Prognosis is still poor in aggressive and indolent variants, with survival rates from months to few years...
April 20, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29673190/the-role-of-mirnas-in-virus-mediated-oncogenesis
#18
REVIEW
Zuzana Vojtechova, Ruth Tachezy
To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), human herpesvirus 8 (HHV-8) or polyomaviruses, and transregulating retroviruses such as HIV or HTLV-1. Most of these viruses express short noncoding RNAs called miRNAs to regulate their own gene expression or to influence host gene expression and thus contribute to the carcinogenic processes...
April 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29665857/the-htlv-1-oncoprotein-tax-is-modified-by-the-ubiquitin-related-modifier-1-urm1
#19
Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran, Carine Mouawad, Zeina Dassouki, Marwan El-Sabban, Margret Shirinian, Caroline Grabbe, Ali Bazarbachi
BACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity and subcellular localization of Tax is strongly influenced by posttranslational modifications, among which ubiquitylation and SUMOylation have been identified as key regulators of the nuclear/cytoplasmic shuttling of Tax, as well as its ability to activate NF-κB signaling...
April 17, 2018: Retrovirology
https://www.readbyqxmd.com/read/29663494/phylogenetic-analysis-of-htlv-1-in-iranian-blood-donors-hiv-1-positive-patients-and-patients-with-beta-thalassemia
#20
Leila Pirayeshfard, Zohreh Sharifi, Sedigheh Amini-Kafiabad, Nasrin Haghnazari Sadaghiani
BACKGROUND: Human T-cell leukemia virus (HTLV) has been associated with various disease types. Since the discovery of the virus in 1980, seven subtypes of the virus have been identified. HTLV is widespread and endemic in some regions, such as Japan, Africa, South America, and northeast Iran. This study aimed to identify HTLV-1 genotype and also to analyze the nucleotide sequence of the LTR region in three groups, including blood donors, HIV-1+ patients, and β-thalassemia patients. MATERIALS AND METHODS: In this cross-sectional study, 2200 samples were collected from blood donors in Tehran (2000 samples), HIV-1+ patients (100 samples) and β-thalassemia patients (100 samples)...
April 16, 2018: Journal of Medical Virology
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