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Fructose 1-6 biphosphatase

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https://www.readbyqxmd.com/read/29218237/increased-mir-21a-provides-metabolic-advantages-through-suppression-of-fbp1-expression-in-non-small-cell-lung-cancer-cells
#1
Qingchun Dai, Na Li, Xiaohong Zhou
Lung cancer is the most common solid tumor and the leading cause of cancer-related mortality worldwide. miR-21 is one of the most commonly observed aberrant miRNAs in human cancers. However, the biological roles of miR-21 in glucose metabolism of non-small cell lung cancer (NSCLC) cells remain unknown. In the present study, our findings demonstrated that miR-21 promoted glucose uptake and increased TXNIP expression. miR-21 increased lactate generation and decreased oxygen consumption in NSCLC cells. Moreover, we found that miR-21 promoted glycolysis and decreased OXPHOS...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29061364/inflammatory-microglia-are-glycolytic-and-iron-retentive-and-typify-the-microglia-in-app-ps1-mice
#2
R Holland, A L McIntosh, O M Finucane, V Mela, A Rubio-Araiz, G Timmons, S A McCarthy, Y K Gun'ko, M A Lynch
Microglia, like macrophages, can adopt inflammatory and anti-inflammatory phenotypes depending on the stimulus. In macrophages, the evidence indicates that these phenotypes have different metabolic profiles with lipopolysaccharide (LPS)- or interferon-γ (IFNγ)-stimulated inflammatory cells switching to glycolysis as their main source of ATP and interleukin-4 (IL-4)-stimulated cells utilizing oxidative phosphorylation. There is a paucity of information regarding the metabolic signatures of inflammatory and anti-inflammatory microglia...
October 20, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28492150/selective-screening-for-organic-acidurias-and-amino-acidopathies-in-pakistani-children
#3
Noreen Abbas Sherazi, Aysha Habib Khan, Lena Jafri, Azeema Jamil, Nasir Ali Khan, Bushra Afroze
OBJECTIVE: To determine the frequency of organic acidurais (OA) and amino acidopathies (AA) in selected high-risk patients screened in two years. STUDY DESIGN: Retrospective Observational study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital (AKUH), Karachi, from January 2013 to December 2014. METHODOLOGY: Patients with OA and AA were included in the study and patients with IMDs other than OA and AA were excluded...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28394358/mage-trim28-complex-promotes-the-warburg-effect-and-hepatocellular-carcinoma-progression-by-targeting-fbp1-for-degradation
#4
X Jin, Y Pan, L Wang, L Zhang, R Ravichandran, P R Potts, J Jiang, H Wu, H Huang
Hepatocellular carcinoma (HCC) is one of the leading cause of cancer death in the world. Fructose-1,6-biphosphatase (FBP1), a rate-limiting enzyme in gluconeogenesis, has been identified recently as a tumor suppressor in HCC and other cancer types. In this study, we demonstrated that the tripartite motif-containing protein 28 (TRIM28) binds directly to and promotes FBP1 for ubiquitination and degradation. MAGE-A3 and MAGE-C2, which are known to be overexpressed in HCC, can enhance TRIM28-dependent degradation of FBP1 by forming ubiquitin ligase complexes with TRIM28...
April 10, 2017: Oncogenesis
https://www.readbyqxmd.com/read/27858215/effects-of-amino-acid-supplementations-on-metabolic-and-physiological-parameters-in-atlantic-cod-gadus-morhua-under-stress
#5
Marcelino Herrera, María Antonia Herves, Inmaculada Giráldez, Kristin Skar, Hanne Mogren, Atle Mortensen, Velmurugu Puvanendran
The effects of tryptophan (Trp) and phenylalanine (Phe) diet supplementation on the stress and metabolism of the Atlantic cod have been studied. Fish were fed diet supplemented with Trp or Phe or control diet for 1 week. At the end of the feeding trial, fish were subjected to air exposure or heat shock. Following samples of blood, liver and muscle were taken from the fish and were analyzed for stress and metabolic indicators. After an air exposure, plasma cortisol levels in fish fed with Trp and Phe diets were lower compared to the fish fed the control diet...
April 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27764724/innate-immune-cell-activation-and-epigenetic-remodeling-in-symptomatic-and-asymptomatic-atherosclerosis-in-humans-in%C3%A2-vivo
#6
Siroon Bekkering, Inge van den Munckhof, Tim Nielen, Evert Lamfers, Charles Dinarello, Joost Rutten, Jacqueline de Graaf, Leo A B Joosten, Mihai G Netea, Marc E R Gomes, Niels P Riksen
BACKGROUND AND AIMS: We have recently reported that monocytes can undergo functional and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after brief in vitro exposure to atherogenic stimuli such as oxidized LDL. This process is termed 'trained immunity', and is mediated by epigenetic remodeling and a metabolic switch towards increased aerobic glycolysis. We hypothesize that trained immunity contributes to atherogenesis. Therefore, we investigated the inflammatory phenotype and epigenetic remodeling of monocytes from patients with and without established atherosclerosis...
October 12, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27128560/ablation-of-sirt3-causes-coronary-microvascular-dysfunction-and-impairs-cardiac-recovery-post-myocardial-ischemia
#7
Xiaochen He, Heng Zeng, Jian-Xiong Chen
RATIONALE: Sirtuin (SIRT3), a major nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase in mitochondria, declines with aging and its ablation is associated with accelerated development of cardiovascular diseases. However, the role of SIRT3 in coronary microvascular function and post-MI recovery has not been completely understood. OBJECTIVE: The goal was to investigate whether ablation of SIRT3 causes coronary microvascular dysfunction, exacerbates post-myocardial ischemia (MI) cardiac dysfunction and impairs cardiac recovery...
July 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27105833/increasing-levels-of-dietary-crystalline-methionine-affect-plasma-methionine-profiles-ammonia-excretion-and-the-expression-of-genes-related-to-the-hepatic-intermediary-metabolism-in-rainbow-trout-oncorhynchus-mykiss
#8
Marine Rolland, Peter V Skov, Bodil K Larsen, Jørgen Holm, Pedro Gómez-Requeni, Johanne Dalsgaard
Strictly carnivorous fish with high requirements for dietary protein, such as rainbow trout (Oncorhynchus mykiss) are interesting models for studying the role of amino acids as key regulators of intermediary metabolism. Methionine is an essential amino acid for rainbow trout, and works as a signalling factor in different metabolic pathways. The study investigated the effect of increasing dietary methionine intake on the intermediary metabolism in the liver of juvenile rainbow trout. For this purpose, five diets were formulated with increasing methionine levels from 0...
August 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/26284610/glycolytic-reprogramming-in-myofibroblast-differentiation-and-lung-fibrosis
#9
Na Xie, Zheng Tan, Sami Banerjee, Huachun Cui, Jing Ge, Rui-Ming Liu, Karen Bernard, Victor J Thannickal, Gang Liu
RATIONALE: Dysregulation of cellular metabolism has been shown to participate in several pathologic processes. However, the role of metabolic reprogramming is not well appreciated in the pathogenesis of organ fibrosis. OBJECTIVES: To determine if glycolytic reprogramming participates in the pathogenesis of lung fibrosis and assess the therapeutic potential of glycolytic inhibition in treating lung fibrosis. METHODS: A cell metabolism assay was performed to determine glycolytic flux and mitochondrial respiration...
December 15, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26161595/comparison-of-the-anti-diabetic-effects-of-resveratrol-gliclazide-and-losartan-in-streptozotocin-induced-experimental-diabetes
#10
COMPARATIVE STUDY
Ümit Can Yazgan, Ezel Taşdemir, Hakkı Murat Bilgin, Basra Deniz Obay, Abdurrahman Şermet, Bilal Elbey
AIM: The aim of this study was to compare the effect of the resveratrol with gliclazide and losartan in streptozotocin induced diabetic rats. MATERIALS AND METHODS: Adult male Wistar albino rats were divided into five groups of seven rats each. Diabetes was induced with a single intraperitoneal (i.p.) injection of streptozotocin (55 mg/kg). Rats with blood glucose levels above 250 mg/dl after 48 h of streptozotocin injection were included in the diabetic group...
2015: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/25469630/diet-with-diphenyl-diselenide-mitigates-quinclorac-toxicity-in-silver-catfish-rhamdia-quelen
#11
Charlene Menezes, Ignacio Ruiz-Jarabo, Juan Antonio Martos-Sitcha, Jossiele Leitemperger, Bernardo Baldisserotto, Juan Miguel Mancera, Denis Broock Rosemberg, Vania Lucia Loro
In this study, the protective effects of diphenyl diselenide [(PhSe)2] on quinclorac- induced toxicity were investigated in silver catfish (Rhamdia quelen). The fish were fed for 60 days with a diet in the absence or in the presence of 3.0 mg/Kg (PhSe)2. Animals were further exposed to 1 mg/L quinclorac for 8 days. At the end of experimental period, fish were euthanized and biopsies from liver and gills, as well as blood samples, were collected. The cortisol and metabolic parameters were determined in plasma, and those enzyme activities related to osmoregulation were assayed in the gills...
2014: PloS One
https://www.readbyqxmd.com/read/25403153/stress-response-in-silver-catfish-rhamdia-quelen-exposed-to-the-essential-oil-of-hesperozygis-ringens
#12
Cândida Toni, Juan Antonio Martos-Sitcha, Ignacio Ruiz-Jarabo, Juan Miguel Mancera, Gonzalo Martínez-Rodríguez, Carlos Garrido Pinheiro, Berta Maria Heinzmann, Bernardo Baldisserotto
This study investigated the effects of prolonged exposure of silver catfish (Rhamdia quelen) to the essential oil (EO) of Hesperozygis ringens. Ventilatory rate (VR), stress and metabolic indicators, energy enzyme activities, and mRNA expression of adenohypophyseal hormones were examined in specimens that were exposed for 6 h to 0 (control), 30 or 50 µL L(-1) EO of H. ringens in water. Reduction in VR was observed in response to each treatment, but no differences were found between treatments. Plasma glucose, protein, and osmolality increased in fish exposed to 50 µL L(-1)...
February 2015: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/25359860/laminar-shear-stress-inhibits-endothelial-cell-metabolism-via-klf2-mediated-repression-of-pfkfb3
#13
Anuradha Doddaballapur, Katharina M Michalik, Yosif Manavski, Tina Lucas, Riekelt H Houtkooper, Xintian You, Wei Chen, Andreas M Zeiher, Michael Potente, Stefanie Dimmeler, Reinier A Boon
OBJECTIVE: Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. APPROACH AND RESULTS: Here, we show that laminar flow exposure reduced glucose uptake and mitochondrial content in endothelium. Shear stress-mediated reduction of endothelial metabolism was reversed by silencing the flow-sensitive transcription factor Krüppel-like factor 2 (KLF2)...
January 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/25262735/transient-glycolysis-enables-mitochondrial-fusion-and-stimulates-s-phase-entry-the-role-of-foxo3a
#14
Slavica Tudzarova-Trajkovska, Salvador Moncada
We recently demonstrated that cells arrested by glucose deprivation proceed into S phase when glucose is replenished only in the presence of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3) - an allosteric activator of phosphofructokinase 1 (PFK1), indicating the necessity to upregulate glycolysis at this stage of the cell cycle. PFKFB3 is expressed only transiently in G1, following a decrease in the activity of the ubiquitin ligase APC/C-Cdh1, implicated in PFKFB3 degradation. In the present study we investigate the functional significance of glycolysis in G1 to S transition...
2014: JOP: Journal of the Pancreas
https://www.readbyqxmd.com/read/24283966/annexation-of-a-high-activity-enzyme-in-a-synthetic-three-enzyme-complex-greatly-decreases-the-degree-of-substrate-channeling
#15
Chun You, Y-H Percival Zhang
The self-assembled three-enzyme complex containing triosephosphate isomerase (TIM), aldolase (ALD), and fructose 1,6-biphosphatase (FBP) was constructed via a mini-scaffoldin containing three different cohesins and the three dockerin-containing enzymes. This enzyme complex exhibited 1 order of magnitude higher initial reaction rates than the mixture of noncomplexed three enzymes. In this enzyme cascade reactions, the reaction mediated by ALD was the rate-limiting step. To understand the in-depth role of the rate-limiting enzyme ALD in influencing the substrate channeling effect of synthetic enzyme complexes, low-activity ALD from Thermotoga maritima was replaced with a similar-size ALD isolated from Thermus thermophilus, where the latter had more than 5 times specific activity of the former...
June 20, 2014: ACS Synthetic Biology
https://www.readbyqxmd.com/read/24197077/influence-of-exercise-on-the-distribution-of-enzymes-in-trout-white-muscle-and-kinetic-properties-of-amp-deaminase-from-free-and-bound-fractions
#16
V I Lushchak, K B Storey
Effects of exercise on the distribution of phosphofructokinase (PFK), fructose-1,6-biphosphatase (FBPase), and AMP-deaminase between free and particulate-bound fractions was analyzed in white skeletal muscle of rainbow trout Oncorhynchus mykiss. With a widely used technique for the separation of free and bound enzyme fractions (homogenization in low ionic strength, high sucrose buffer), the data showed that the amount of bound PFK increased from 64 to 95% during burst swimming whereas other enzymes were unaffected...
November 1994: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/24186951/genetic-and-functional-investigation-of-zn-2-cys-6-transcription-factors-rse2-and-rse3-in-podospora-anserina
#17
Elodie Bovier, Carole H Sellem, Adeline Humbert, Annie Sainsard-Chanet
In Podospora anserina, the two zinc cluster proteins RSE2 and RSE3 are essential for the expression of the gene encoding the alternative oxidase (aox) when the mitochondrial electron transport chain is impaired. In parallel, they activated the expression of gluconeogenic genes encoding phosphoenolpyruvate carboxykinase (pck) and fructose-1,6-biphosphatase (fbp). Orthologues of these transcription factors are present in a wide range of filamentous fungi, and no other role than the regulation of these three genes has been evidenced so far...
January 2014: Eukaryotic Cell
https://www.readbyqxmd.com/read/23656373/self-assembly-of-synthetic-metabolons-through-synthetic-protein-scaffolds-one-step-purification-co-immobilization-and-substrate-channeling
#18
Chun You, Y-H Percival Zhang
One-step purification of a multi-enzyme complex was developed based on a mixture of cell extracts containing three dockerin-containing enzymes and one family 3 cellulose-binding module (CBM3)-containing scaffoldin through high-affinity adsorption on low-cost solid regenerated amorphous cellulose (RAC). The three-enzyme complex, called synthetic metabolon, was self-assembled through the high-affinity interaction between the dockerin in each enzyme and three cohesins in the synthetic scaffoldin. The metabolons were either immobilized on the external surface of RAC or free when the scaffoldin contained an intein between the CBM3 and three cohesins...
February 15, 2013: ACS Synthetic Biology
https://www.readbyqxmd.com/read/23453623/loss-of-fbp1-by-snail-mediated-repression-provides-metabolic-advantages-in-basal-like-breast-cancer
#19
Chenfang Dong, Tingting Yuan, Yadi Wu, Yifan Wang, Teresa W M Fan, Sumitra Miriyala, Yiwei Lin, Jun Yao, Jian Shi, Tiebang Kang, Pawel Lorkiewicz, Daret St Clair, Mien-Chie Hung, B Mark Evers, Binhua P Zhou
The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells with cancer stem cell (CSC)-like characteristics. We show that the Snail-G9a-Dnmt1 complex, which is critical for E-cadherin promoter silencing, is also required for the promoter methylation of fructose-1,6-biphosphatase (FBP1) in basal-like breast cancer (BLBC). Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and maintenance of ATP production under hypoxia...
March 18, 2013: Cancer Cell
https://www.readbyqxmd.com/read/23305114/improved-glycemic-control-pancreas-protective-and-hepatoprotective-effect-by-traditional-poly-herbal-formulation-qurs-tabasheer-in-streptozotocin-induced-diabetic-rats
#20
Danish Ahmed, Manju Sharma, Alok Mukerjee, Pramod W Ramteke, Vikas Kumar
BACKGROUND: The present study was undertaken to evaluate the antihyperglycemic, antihyperlipidemic and hepatoprotective effect of a traditional unani formulation "Qurs Tabasheer" in streptozotocin (STZ) induced diabetic wistar rats. Up till now no study was undertaken to appraise the efficacy of "Qurs Tabasheer" in the diabetic rats. Qurs Tabasheer is a unani formulation restraining preparations from five various herbs namely Tukhme Khurfa (Portulaca oleracea seed), Gule Surkh (Rosa damascena flower), Gulnar (Punica granatum flower), Tabasheer (Bambusa arundinasia dried exudate on node), Tukhme Kahu (Lactuca sativa Linn seed)...
2013: BMC Complementary and Alternative Medicine
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