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Plasma exchange

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https://www.readbyqxmd.com/read/29351430/dynamic-changes-in-nitric-oxide-synthase-expression-are-involved-in-seawater-acclimation-of-rainbow-trout-oncorhynchus-mykiss
#1
Lucie Gerber, Frank B Jensen, Steffen S Madsen
Recent research has shown that nitric oxide (NO) produced by nitric oxide synthases (Nos) is an inhibitor of ion transporter activity and a modulator of epithelial ion transport in fish but little is known on changes in the Nos/NO system during osmotic stress. We hypothesized that the Nos/NO system responds to salinity changes as an integrated part of the acclimation process. Expression and localization of nos1/Nos1 and nos2/Nos2 were investigated in gill, kidney and intestine of FW- and SW-transferred trout using qPCR, Western blotting and immunohistochemistry, along with expressional changes of major ion transporters in the gill...
December 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351414/the-murine-choroid-plexus-epithelium-expresses-the-2cl-h-exchanger-clc-7-and-na-h-exchanger-nhe6-in-the-luminal-membrane-domain
#2
Helle H Damkier, Henriette L Christensen, Inga B Christensen, Qi Wu, Robert A Fenton, Jeppe Praetorius
The choroid plexus epithelium within the brain ventricles secretes the majority of the cerebrospinal fluid (CSF). The luminal Na+,K+-ATPase acts in concert with a host of other transport proteins to mediate efficient fluid secretion across the epithelium. The CSF contains little protein buffer, but the pH value seems nonetheless maintained within narrow limits, even when faced with acid/base challenges. The involvement of choroid plexus acid/base transporters in CSF pH regulation is highlighted by the expression of several acid/base transporters in the epithelium...
December 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29349874/assessment-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-of-the-effects-of-preanalytical-variables-on-serum-peptidome-profiles-following-long-term-sample-storage
#3
Sachio Tsuchida, Mamoru Satoh, Hiroshi Umemura, Kazuyuki Sogawa, Masaki Takiwaki, Takayuki Ishige, Yui Miyabayashi, Yuuya Iwasawa, Sohei Kobayashi, Minako Beppu, Motoi Nishimura, Yoshio Kodera, Kazuyuki Matsushita, Fumio Nomura
PURPOSE: Human serum and plasma are often used as clinical specimens in proteomics analyses, and peptidome profiling of human serum is a promising tool for identifying novel disease-associated biomarkers. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used for peptidomic biomarker discovery. Careful sample collection and handling are required as either can have a profound impact on serum peptidome patterns, yet the effects of preanalytical variables on serum peptidome profiles have not been completely elucidated...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29348275/microangiopathies-in-pregnancy
#4
Jailan Elayoubi, Kavitha Donthireddy, Divyesh Reddy Nemakayala
Thrombotic thrombocytopenic purpura (TTP) is a potentially reversible, life-threatening medical emergency. We present a case of a 21-year-old female with evidence of haemolytic anaemia based on the presence of positive markers of haemolysis. Negative Coomb's test, thrombocytopenia and placental infarcts raised suspicion for a thrombotic microangiopathy. She was diagnosed with TTP and managed with emergency plasma exchange. Her recovery was immediate.A presumptive diagnosis of TTP should be based on the presence of microangiopathic haemolytic anaemia with thrombocytopenia and plasma exchange should be initiated while complete work up is pending...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29341897/toxicity-and-toxicokinetics-of-amanita-exitialis-in-beagle-dogs
#5
Jian Sun, Yu-Min Niu, Yu-Tao Zhang, Hai-Jiao Li, Yu Yin, Yi-Zhe Zhang, Pei-Bin Ma, Jing Zhou, Lie Huang, Hong-Shun Zhang, Cheng-Ye Sun
In this study, the toxicology of A. exitialis, a lethal mushroom found in China, and the toxicokinetics of peptide toxins contained in it were evaluated. Beagles were fed A. exitialis powder (20 or 60 mg/kg) in starch capsules, after which they were assessed for signs of toxicity, as well as biochemical and pathological changes. Ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was used to assay the peptide toxins. The total peptide toxins in A. exitialis was 3482.6 ± 124...
January 13, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29341461/effect-of-immediate-and-prolonged-glp-1-receptor-agonist-administration-on-uric-acid-and-its-kidney-clearance-post-hoc-analyses-of-four-clinical-trials
#6
Lennart Tonneijck, Marcel H A Muskiet, Mark M Smits, Petter Bjornstad, Mark H H Kramer, Michaela Diamant, Ewout J Hoorn, Jaap A Joles, Daniël H van Raalte
AIMS: To determine effects of glucagon-like peptide (GLP)-1 receptor agonists (RA) on uric acid (UA)-levels and kidney UA-clearance. MATERIAL AND METHODS: Post-hoc analyses of four controlled clinical trials, which assessed actions of GLP-1RA-administration on kidney physiology. Immediate effects of GLP-1RA exenatide-infusion versus placebo was determined in 9 healthy overweight males (Study-A) and in 52 overweight T2DM-patients (Study-B). Effects were also examined of 12-week long-acting GLP-1RA liraglutide versus placebo in 36 overweight T2DM-patients (Study-C) and of 8-week short-acting GLP-1RA lixisenatide versus once-daily titrated insulin-glulisine in 35 overweight T2DM-patients (Study-D)...
January 17, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29339798/shedding-light-on-the-cell-biology-of-extracellular-vesicles
#7
REVIEW
Guillaume van Niel, Gisela D'Angelo, Graça Raposo
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple physiological and pathological processes. Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material. Knowledge of the cellular processes that govern extracellular vesicle biology is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/or analysis...
January 17, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29339226/model-and-methods-to-assess-hepatic-function-from-indocyanine-green-fluorescence-dynamical-measurements-of-liver-tissue
#8
Chloe Audebert, Irene E Vignon-Clementel
The indocyanine green (ICG) clearance, presented as plasma disappearance rate is, presently, a reliable method to estimate the hepatic "function". However, this technique is not instantaneously available and thus cannot been used intra-operatively (during liver surgery). Near-infrared spectroscopy enables to assess hepatic ICG concentration over time in the liver tissue. This article proposes to extract more information from the liver intensity dynamics by interpreting it through a dedicated pharmacokinetics model...
January 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29338584/effect-of-acute-ingestion-of-%C3%AE-hydroxybutyrate-salts-on-the-response-to-graded-exercise-in-trained-cyclists
#9
Mark Evans, Ella Patchett, Rickard Nally, Rachel Kearns, Matthew Larney, Brendan Egan
Acute ingestion of ketone salts induces nutritional ketosis by elevating β-hydroxybutyrate (βHB), but few studies have examined the metabolic effects of ingestion prior to exercise. Nineteen trained cyclists (12 male, 7 female) undertook graded exercise (8 min each at ∼30%, 40%, 50%, 60%, 70%, and 80% VO2peak) on a cycle ergometer on two occasions separated by either 7 or 14 days. Trials included ingestion of boluses of either (i) plain water (3.8 mL kg body mass-1) (CON) or (ii) βHB salts (0.38 g kg body mass-1) in plain water (3...
January 16, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29338180/hollow-echinus-like-pdcuco-alloy-for-superior-efficient-catalysis-of-ethanol
#10
Yalan Shu, Xiaoqin Shi, Yuanyuan Ji, Ying Wen, Xiaoyu Guo, Ye Ying, Yiping Wu, Hai-Feng Yang
Large-scale preparation of hollow echinus-like PdCuCo alloy nanostructures with high surface area-to-volume ratio, rich active sites and relatively efficient catalytic activity have attracted considerable research interest. Herein, we present an economic and facile approach to synthesize hollow echinus-like PdCuCo alloy nanostructures (HENSs) by galvanic exchange reactions using Co nanospheres as sacrificial templates. Moreover, the catalytic activity could be adjusted via changing the composition of catalyst...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29337869/aquaporin-expression-and-water-transport-pathways-inside-leaves-are-affected-by-nitrogen-supply-through-transpiration-in-rice-plants
#11
Lei Ding, Yingrui Li, Limin Gao, Zhifeng Lu, Min Wang, Ning Ling, Qirong Shen, Shiwei Guo
The photosynthetic rate increases under high-N supply, resulting in a large CO₂ transport conductance in mesophyll cells. It is less known that water movement is affected by nitrogen supply in leaves. This study investigated whether the expression of aquaporin and water transport were affected by low-N (0.7 mM) and high-N (7 mM) concentrations in the hydroponic culture of four rice varieties: (1) Shanyou 63 (SY63), a hybrid variant of the indica species; (2) Yangdao 6 (YD6), a variant of indica species; (3) Zhendao 11 (ZD11), a hybrid variant of japonica species; and (4) Jiuyou 418 (JY418), another hybrid of the japonica species...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29334938/therapeutic-plasma-exchange-in-a-tertiary-care-center-185-patients-undergoing-912-treatments-a-one-year-retrospective-analysis
#12
Julius J Schmidt, Firas Asper, Gunilla Einecke, Gabriele Eden, Carsten Hafer, Jan T Kielstein
BACKGROUND: Therapeutic plasma exchange (TPE) is increasingly used throughout the world. Although the procedure itself is fairly standardized, it is yet unknown how the underlying disease entities influence the key coordinates of the treatment. METHODS: Retrospective chart review. The treatment indications were clustered into four categories. Data are presented as median and interquartile (25-75%) range [IQR]. RESULTS: Within 1 year, 912 TPE treatments were performed in 185 patients (90 female, 48...
January 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29334853/therapeutic-plasma-exchange-use-in-pediatric-neurologic-disorders-at-a-tertiary-care-center-a-10-year-review
#13
Sonika Agarwal, Jake R Keller, Chloe E Nunneley, Eyal Muscal, Michael C Braun, Poyyapakkam Srivaths, Timothy E Lotze
Pediatric neurologic conditions requiring therapeutic plasma exchange are rare in children and literature is sparse. The study aims to determine the outcomes, safety, and feasibility of therapeutic plasma exchange treatment in pediatric neurologic disorders. This retrospective analysis looked at the outcomes and safety of therapeutic plasma exchange in children (n = 50) with neurologic conditions. Patient age ranged <1 to 19 years old with a mean of 10.35 years. Of the 50 children treated with plasmapheresis, 26 patients received inpatient rehabilitation...
February 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29331508/compartmentalized-crosstalk-of-cftr-and-tmem16a-ano1-through-epac1-and-adcy1
#14
Joana Lérias, Madalena Pinto, Roberta Benedetto, Rainer Schreiber, Margarida Amaral, Massimo Aureli, Karl Kunzelmann
Airway epithelial cells express both Ca2+ activated TMEM16A/ANO1 and cAMP activated CFTR anion channels. Previous work suggested a significant crosstalk of intracellular Ca2+ and cAMP signaling pathways, leading to activation of both chloride channels. We demonstrate that in airway epithelial cells, stimulation of purinergic or muscarinic G-protein coupled receptors (GPCRs) activates TMEM16A and CFTR. Additional expression of Gq/11 and phospholipase C coupled GPCRs strongly enhanced the crosstalk between Ca2+- and cAMP-dependent signaling...
January 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29321928/lung-cancer-development-in-the-patient-with-granulomatosis-with-polyangiitis-during-long-term-treatment-with-cyclophosphamide-first-documented-case
#15
Midori Toriyama, Etsuko Tagaya, Tomoko Yamamoto, Mitsuko Kondo, Yoji Nagashima, Jun Tamaoki
A 65-year-old man was diagnosed with granulomatosis with polyangiitis (GPA) at the age of 47, when cytoplasmic anti-neutrophil cytoplasmic antibody (C-ANCA) serology was positive, and he had multiple nodular shadows in both lungs. He had been treated with prednisolone, cyclophosphamide (CPA) and plasma exchange. At the age of 64, a nodular shadow was newly detected in the right lower lung field and serum tumour marker increased. Subsequent positron emission tomography/computed tomography scan demonstrated accumulations of fluorodexyglucose (FDG) in the same area, mediastinum lymph nodes, thoracic wall, right iliac bone, and right retroperitoneum...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29321925/lupus-pneumonitis-presenting-with-high-titre-of-anti-ro-antibody
#16
Mei-Chuan Chen, Yueh-Lin Wu, Kai-Ling Lee, Kevin S Lai, Chi-Li Chung
Lupus pneumonitis carries high mortality and is a rare manifestation of systemic lupus erythematosus (SLE). However, it is difficult to diagnose and is often mistaken as pneumonia, alveolar haemorrhage, or organizing pneumonia. Previous studies demonstrated that serum anti-Ro antibodies are elevated more frequently in SLE patients with pneumonitis than in those without. We report a 21-year-old female who was newly diagnosed as having SLE with nephritis and who suddenly developed right lung opacity and rapidly progressed to severe hypoxaemia despite the use of broad-spectrum antibiotics...
January 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29321467/importance-of-regular-and-maintenance-therapy-adherence-in-neuromyelitis-optica-nmo-lessons-from-a-repeating-relapse-case
#17
Jing Miao, Doreen E Aboagye, Boris Chulpayev, Lin Liu, Gary Ishkanian, Bangaruraju Kolanuvada, Dariush Alaie, Richard L Petrillo
BACKGROUND Neuromyelitis optica (NMO) is a rare demyelinating disease of the central nervous system; NMO predominantly affects the spinal cord and optic nerves. The diagnosis is based on history, clinical presentation, seropositive NMO-IgG antibody, and notably, exclusion of other diseases. Despite the absence of definitive therapeutic strategies for NMO, methylprednisolone pulse therapy and plasma exchange are used for acute phase treatment, while immunosuppressive agent(s) are recommended to prevent relapses and improve prognosis...
January 11, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29321424/a-case-of-anti-musk-antibody-positive-myasthenia-gravis-successfully-treated-with-outpatient-periodic-weekly-blood-purification-therapy
#18
Kentaro Deguchi, Kosuke Matsuzono, Yumiko Nakano, Syoichiro Kono, Kota Sato, Shoko Deguchi, Katsuyuki Tanabe, Nozomi Hishikawa, Yasuyuki Ota, Toru Yamashita, Kiyoe Ohta, Masakatsu Motomura, Koji Abe
A 37-year-old man with anti-muscle-specific tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) presented with subacute progressive dysphagia and muscle weakness of the neck and bilateral upper extremities. Conventional immune-suppressive treatments and high-dose intravenous immunoglobulin were ineffective. He then displayed repeated exacerbations and remissions over the course of two years, despite two to four sessions of plasma exchange (PE) every two months. The patient was successfully treated with outpatient periodic weekly blood purification therapy with alternative PE and double-filtration plasmapheresis using an internal shunt...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29318981/magnesium-homeostasis-in-cattle-absorption-and-excretion
#19
Holger Martens, Sabine Leonhard-Marek, Monika Röntgen, Friederike Stumpff
Magnesium (Mg2+) is an essential mineral without known specific regulatory mechanisms. In ruminants, plasma Mg2+ concentration depends primarily on the balance between Mg2+ absorption and Mg2+ excretion. The primary site of Mg2+ absorption is the rumen, where Mg2+ is apically absorbed by both potential-dependent and potential-independent uptake mechanisms, reflecting involvement of ion channels and electroneutral transporters, respectively. Transport is energised in a secondary active manner by a basolateral Na+/Mg2+ exchanger...
January 10, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29317197/structural-determinants-of-phorbol-ester-binding-activity-of-the-c1a-and-c1b-domains-of-protein-kinase-c-theta
#20
Agnes Czikora, Satyabrata Pany, Youngki You, Amandeep S Saini, Nancy E Lewin, Gary A Mitchell, Adelle Abramovitz, Noemi Kedei, Peter M Blumberg, Joydip Das
The PKC isozymes represent the most prominent family of signaling proteins mediating response to the ubiquitous second messenger diacylglycerol. Among them, PKCθ is critically involved in T-cell activation. Whereas all the other conventional and novel PKC isoforms have twin C1 domains with potent binding activity for phorbol esters, in PKCθ only the C1b domain possesses potent binding activity, with little or no activity reported for the C1a domain. In order to better understand the structural basis accounting for the very weak ligand binding of the PKCθ C1a domain, we assessed the effect on ligand binding of twelve amino acid residues which differed between the C1a and C1b domains of PKCθ...
January 6, 2018: Biochimica et Biophysica Acta
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