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Clinical informatics

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https://www.readbyqxmd.com/read/28100277/stress-echo-2020-the-international-stress-echo-study-in-ischemic-and-non-ischemic-heart-disease
#1
Eugenio Picano, Quirino Ciampi, Rodolfo Citro, Antonello D'Andrea, Maria Chiara Scali, Lauro Cortigiani, Iacopo Olivotto, Fabio Mori, Maurizio Galderisi, Marco Fabio Costantino, Lorenza Pratali, Giovanni Di Salvo, Eduardo Bossone, Francesco Ferrara, Luna Gargani, Fausto Rigo, Nicola Gaibazzi, Giuseppe Limongelli, Giuseppe Pacileo, Maria Grazia Andreassi, Bruno Pinamonti, Laura Massa, Marco A R Torres, Marcelo H Miglioranza, Clarissa Borguezan Daros, José Luis de Castro E Silva Pretto, Branko Beleslin, Ana Djordjevic-Dikic, Albert Varga, Attila Palinkas, Gergely Agoston, Dario Gregori, Paolo Trambaiolo, Sergio Severino, Ayana Arystan, Marco Paterni, Clara Carpeggiani, Paolo Colonna
BACKGROUND: Stress echocardiography (SE) has an established role in evidence-based guidelines, but recently its breadth and variety of applications have extended well beyond coronary artery disease (CAD). We lack a prospective research study of SE applications, in and beyond CAD, also considering a variety of signs in addition to regional wall motion abnormalities. METHODS: In a prospective, multicenter, international, observational study design, > 100 certified high-volume SE labs (initially from Italy, Brazil, Hungary, and Serbia) will be networked with an organized system of clinical, laboratory and imaging data collection at the time of physical or pharmacological SE, with structured follow-up information...
January 18, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28090649/-the-pharmacogenomics-research-network-translational-pharmacogenetics-program-outcomes-and-metrics-of-pharmacogenetic-implementations-across-diverse-healthcare-systems
#2
Jasmine A Luzum, Ruth E Pakyz, Amanda R Elsey, Cyrine E Haidar, Josh F Peterson, Michelle Whirl-Carrillo, Samuel K Handelman, Kathleen Palmer, Jill M Pulley, Marc Beller, Jonathan S Schildcrout, Julie R Field, Kristin W Weitzel, Rhonda M Cooper-DeHoff, Larisa H Cavallari, Peter H O'Donnell, Russ B Altman, Naveen Pereira, Mark J Ratain, Dan M Roden, Peter J Embi, Wolfgang Sadee, Teri E Klein, Julie A Johnson, Mary V Relling, Liewei Wang, Richard M Weinshilboum, Alan R Shuldiner, Robert R Freimuth
Numerous pharmacogenetic clinical guidelines and recommendations have been published, but barriers have hindered the clinical implementation of pharmacogenetics. The Translational Pharmacogenetics Program (TPP) of the NIH Pharmacogenomics Research Network was established in 2011 to catalog and contribute to the development of pharmacogenetic implementations at eight US healthcare systems, with the goal to disseminate real-world solutions for the barriers to clinical pharmacogenetic implementation. The TPP collected and normalized pharmacogenetic implementation metrics through June 2015, including gene-drug pairs implemented, interpretations of alleles and diplotypes, numbers of tests performed and actionable results, and workflow diagrams...
January 16, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28077885/designing-and-implementation-of-retina-image-drawing-system-and-automatic-report-generation-from-retina-examinations
#3
Reza Safdari, Mehrshad Mokhtaran, Shahram Tahmasebian
INTRODUCTION: Electronic medical records as one of major parts of electronic health records is an important application of Medical Informatics. EMR includes different types of data, Graphical items being one of these data types. To this end, a standard structure for storing and recovering and finally exchanging this data type is required. In order to standardize information items in this research, UMLS standard is used. In this research, graphical information from fondues designing in retina surgery forms is used for the task of implementation...
October 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28067027/high-density-lipoproteins-in-high-resolution-will-proteomics-solve-the-paradox-for-cardiovascular-risk
#4
Ferheen Baig, Abhishek Joshi, Manuel Mayr
While lipid abnormalities continue to account for over 60% of the population attributable for myocardial infarction, the well-known inverse correlation between plasma high-density lipoprotein cholesterol and cardiovascular risk has failed to deliver clinically useful therapeutic interventions. Thus, there is an unmet need to better understand the functionality of different high-density lipoprotein particles. Targeted high resolution lipoproteomics provides an innovative approach to studying the kinetics of high-density lipoprotein particles...
January 9, 2017: Proteomics
https://www.readbyqxmd.com/read/28059689/an-integrated-health-neighbourhood-framework-to-optimise-the-use-of-ehr-data
#5
Siaw-Teng Liaw, Simon De Lusignan
 General practice should become the hub of integrated health neighbourhoods (IHNs), which involves sharing of information to ensure that medical homes are also part of learning organisations that use electronic health record (EHR) data for care, decision making, teaching and learning, quality improvement and research. The IHN is defined as the primary and ambulatory care services in a locality that relates largely to a single hospital-based secondary care service provider and is the logical denominator and unit of comparison for the optimal use of EHR data and health information exchange (HIE) to facilitate integration and coordination of care...
October 4, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28057607/the-value-of-electronic-medical-record-implementation-in-mental-health-care-a-case-study
#6
Sanaz Riahi, Ilan Fischler, Melanie I Stuckey, Philip E Klassen, John Chen
BACKGROUND: Electronic medical records (EMR) have been implemented in many organizations to improve the quality of care. Evidence supporting the value added to a recovery-oriented mental health facility is lacking. OBJECTIVE: The goal of this project was to implement and customize a fully integrated EMR system in a specialized, recovery-oriented mental health care facility. This evaluation examined the outcomes of quality improvement initiatives driven by the EMR to determine the value that the EMR brought to the organization...
January 5, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28050715/workflow-lexicons-in-healthcare-validation-of-the-swim-lexicon
#7
Chris Meenan, Bradley Erickson, Nancy Knight, Jewel Fossett, Elizabeth Olsen, Prerna Mohod, Joseph Chen, Steve G Langer
For clinical departments seeking to successfully navigate the challenges of modern health reform, obtaining access to operational and clinical data to establish and sustain goals for improving quality is essential. More broadly, health delivery organizations are also seeking to understand performance across multiple facilities and often across multiple electronic medical record (EMR) systems. Interpreting operational data across multiple vendor systems can be challenging, as various manufacturers may describe different departmental workflow steps in different ways and sometimes even within a single vendor's installed customer base...
January 3, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28048918/su-f-r-11-designing-quality-and-safety-informatics-through-implementation-of-a-ct-radiation-dose-monitoring-program
#8
J M Wilson, E Samei
PURPOSE: Recent legislative and accreditation requirements have driven rapid development and implementation of CT radiation dose monitoring solutions. Institutions must determine how to improve quality, safety, and consistency of their clinical performance. The purpose of this work was to design a strategy and meaningful characterization of results from an in-house, clinically-deployed dose monitoring solution. METHODS: A dose monitoring platform was designed by our imaging physics group that focused on extracting protocol parameters, dose metrics, and patient demographics and size...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048762/su-f-t-130-18f-fdg-uptake-dose-response-in-lung-correlates-linearly-with-proton-therapy-dose
#9
D Kim, U Titt, D Mirkovic
PURPOSE: Analysis of clinical outcomes in lung cancer patients treated with protons using 18F-FDG uptake in lung as a measure of dose response. METHODS: A test case lung cancer patient was selected in an unbiased way. The test patient's treatment planning and post treatment positron emission tomography (PET) were collected from picture archiving and communication system at the UT M.D. Anderson Cancer Center. Average computerized tomography scan was registered with post PET/CT through both rigid and deformable registrations for selected region of interest (ROI) via VelocityAI imaging informatics software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048685/tu-d-201-08-experience-complying-with-the-joint-commission-element-of-performance-on-radiation-dose-index-monitoring
#10
M P Supanich
PURPOSE: A new Joint Commission element of performance effective July 2015 requires incidents where the radiation dose index exceeds a defined level be reviewed, analyzed and compared to external benchmarks. This work offers a comprehensive review of the CT exams in which the notification level was exceeded and the reason at one academic medical center. This review may help other institutions set reference levels at clinically relevant values. METHODS: Radiation Dose Structured Reports from each of the 5 diagnostic CT scanners at our institution are automatically sent to our radiation dose index monitoring software platform, Radimetrics from Bayer Healthcare...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047995/tu-fg-206-00-imaging-informatics
#11
Paul Nagy
The field of imaging informatics is a subfield of biomedical informatics that combines medical physics with computer, clinical, and cognitive sciences. In this session jointly sponsored with the Society of Imaging Informatics in Medicine, we will provide an overview of the field starting with the highly applied role of information technology working with imaging modalities to research areas in computer vision, annotation markup, and semantic ontologies that can leverage machine encoded reasoning systems. We will highlight new technologies that are beneficial to medical physicists conducting research as well as translating research into clinical practice...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047914/tu-fg-206-03-imaging-informatics-for-the-medical-physicist
#12
P Nagy
The field of imaging informatics is a subfield of biomedical informatics that combines medical physics with computer, clinical, and cognitive sciences. In this session jointly sponsored with the Society of Imaging Informatics in Medicine, we will provide an overview of the field starting with the highly applied role of information technology working with imaging modalities to research areas in computer vision, annotation markup, and semantic ontologies that can leverage machine encoded reasoning systems. We will highlight new technologies that are beneficial to medical physicists conducting research as well as translating research into clinical practice...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047330/tu-fg-206-01-standards-support-for-color-in-medical-imaging
#13
M Flynn
The field of imaging informatics is a subfield of biomedical informatics that combines medical physics with computer, clinical, and cognitive sciences. In this session jointly sponsored with the Society of Imaging Informatics in Medicine, we will provide an overview of the field starting with the highly applied role of information technology working with imaging modalities to research areas in computer vision, annotation markup, and semantic ontologies that can leverage machine encoded reasoning systems. We will highlight new technologies that are beneficial to medical physicists conducting research as well as translating research into clinical practice...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046662/tu-fg-206-02-medical-physics-imaging-informatics-in-the-classroom-and-in-practice
#14
W Sensakovic
The field of imaging informatics is a subfield of biomedical informatics that combines medical physics with computer, clinical, and cognitive sciences. In this session jointly sponsored with the Society of Imaging Informatics in Medicine, we will provide an overview of the field starting with the highly applied role of information technology working with imaging modalities to research areas in computer vision, annotation markup, and semantic ontologies that can leverage machine encoded reasoning systems. We will highlight new technologies that are beneficial to medical physicists conducting research as well as translating research into clinical practice...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28028203/development-of-a-pediatric-adverse-events-terminology
#15
Debbie S Gipson, Eric S Kirkendall, Brenda Gumbs-Petty, Theresa Quinn, A Steen, Amanda Hicks, Ann McMahon, Savian Nicholas, Anna Zhao-Wong, Perdita Taylor-Zapata, Mark Turner, Emily Herreshoff, Charlotte Jones, Jonathan M Davis, Margaret Haber, Steven Hirschfeld
In 2009, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Pediatric Terminology Harmonization Initiative to establish a core library of terms to facilitate the acquisition and sharing of knowledge between pediatric clinical research, practice, and safety reporting. A coalition of partners established a Pediatric Terminology Adverse Event Working Group in 2013 to develop a specific terminology relevant to international pediatric adverse event (AE) reporting...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/28018897/patient-centered-tablet-application-for-improving-medication-adherence-after-a-drug-eluting-stent
#16
Vicki Shah, Anandu Dileep, Carolyn Dickens, Vicki Groo, Betty Welland, Jerry Field, Matthew Baumann, Jose D Flores, Adhir Shroff, Zhongsheng Zhao, Yingwei Yao, Diana J Wilkie, Andrew D Boyd
BACKGROUND/AIMS: This study's objective was to evaluate a patient-centered educational electronic tablet application, "My Interventional Drug-Eluting Stent Educational App" (MyIDEA) to see if there was an increase in patient knowledge about dual antiplatelet therapy (DAPT) and medication possession ratio (MPR) compared to treatment as usual. METHODS: In a pilot project, 24 elderly (≥50 years old) research participants were recruited after a drug-eluting stent...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/28011593/an-informatics-based-approach-to-reducing-heart-failure-all-cause-readmissions-the-stanford-heart-failure-dashboard
#17
Dipanjan Banerjee, Christine Thompson, Charlene Kell, Rajesh Shetty, Yohan Vetteth, Helene Grossman, Aria DiBiase, Michael Fowler
BACKGROUND: Reduction of 30-day all-cause readmissions for heart failure (HF) has become an important quality-of-care metric for health care systems. Many hospitals have implemented quality improvement programs designed to reduce 30-day all-cause readmissions for HF. Electronic medical record (EMR)-based measures have been employed to aid in these efforts, but their use has been largely adjunctive to, rather than integrated with, the overall effort. OBJECTIVES: We hypothesized that a comprehensive EMR-based approach utilizing an HF dashboard in addition to an established HF readmission reduction program would further reduce 30-day all-cause index hospital readmission rates for HF...
December 23, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28005393/multiplexed-single-cell-imaging-past-present-and-future
#18
Jia-Ren Lin
Jia-Ren Lin from the Laboratory of Systems Pharmacology at Harvard Medical School was awarded best poster at the annual Society of Biomolecular Imaging and Informatics meeting held in Boston, September 2016. His work focuses on single-cell imaging, especially on developing new methods for simultaneously detecting many antigens, named cyclic immunofluorescence (CycIF). This method could be applied in different stages of drug development, from discovery phase, preclinical research to clinical research. The current works and future directions of CycIF method are summarized in the following overview...
January 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/27995389/equipping-physiologists-with-an-informatics-tool-chest-toward-an-integerated-mitochondrial-phenome
#19
Anders Olav Garlid, Jennifer S Polson, Keith D Garlid, Henning Hermjakob, Peipei Ping
Understanding the complex involvement of mitochondrial biology in disease development often requires the acquisition, analysis, and integration of large-scale molecular and phenotypic data. An increasing number of bioinformatics tools are currently employed to aid in mitochondrial investigations, most notably in predicting or corroborating the spatial and temporal dynamics of mitochondrial molecules, in retrieving structural data of mitochondrial components, and in aggregating as well as transforming mitochondrial centric biomedical knowledge...
December 20, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27975217/top-down-mass-spectrometry-proteomics-to-proteoforms
#20
Steven M Patrie
This chapter highlights many of the fundamental concepts and technologies in the field of top-down mass spectrometry (TDMS), and provides numerous examples of contributions that TD is making in biology, biophysics, and clinical investigations. TD workflows include variegated steps that may include non-specific or targeted preparative strategies, orthogonal liquid chromatography techniques, analyte ionization, mass analysis, tandem mass spectrometry (MS/MS) and informatics procedures. This diversity of experimental designs has evolved to manage the large dynamic range of protein expression and diverse physiochemical properties of proteins in proteome investigations, tackle proteoform microheterogeneity, as well as determine structure and composition of gas-phase proteins and protein assemblies...
2016: Advances in Experimental Medicine and Biology
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