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https://www.readbyqxmd.com/read/29777740/rapid-response-systems
#1
REVIEW
Patrick G Lyons, Dana P Edelson, Matthew M Churpek
INTRODUCTION: Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems. AIMS: We aimed to review the current state of the rapid response literature, including evolving aspects of afferent (risk detection) and efferent (intervention) arms, outcome measurement, process improvement, and implementation. DATA SOURCES: Articles written in English and published in PubMed...
May 16, 2018: Resuscitation
https://www.readbyqxmd.com/read/29774072/twist-promotes-tumor-metastasis-in-basal-like-breast-cancer-by-transcriptionally-upregulating-ror1
#2
Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P Zhou, Jian Shi, Tiebang Kang
Rationale: Twist is a key transcription factor for induction of epithelial-mesenchymal transition (EMT), which promotes cell migration, invasion, and cancer metastasis, confers cancer cells with stem cell-like characteristics, and provides therapeutic resistance. However, the functional roles and targeted genes of Twist in EMT and cancer progression remain elusive. Methods: The potential targeted genes of Twist were identified from the global transcriptomes of T47D/Twist cells by microarray analysis. EMT phenotype was detected by western blotting and immunofluorescence of marker proteins...
2018: Theranostics
https://www.readbyqxmd.com/read/29768633/evaluating-the-efficiency-and-safety-of-speech-recognition-within-a-commercial-electronic-health-record-system-a-replication-study
#3
Tobias Hodgson, Farah Magrabi, Enrico Coiera
OBJECTIVE:  To conduct a replication study to validate previously identified significant risks and inefficiencies associated with the use of speech recognition (SR) for documentation within an electronic health record (EHR) system. METHODS:  Thirty-five emergency department clinicians undertook randomly allocated clinical documentation tasks using keyboard and mouse (KBM) or SR using a commercial EHR system. The experiment design, setting, and tasks (E2) replicated an earlier study (E1), while technical integration issues that may have led to poorer SR performance were addressed...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29766677/sleeping-child-neuroendocrine-cell-hyperplasia-of-infancy-and-polysomnography
#4
Deborah R Liptzin, Stephen M M Hawkins, Brandie D Wagner, Robin R Deterding
OBJECTIVES: Neuroendocrine cell hyperplasia of infancy (NEHI) is a children's interstitial and diffuse lung disease of unknown etiology that presents in infancy with characteristic findings of tachypnea, retractions, crackles, and hypoxemia. At the present, the mainstay of treatment is oxygen supplementation to normalize oxygen saturations and decrease work of breathing. There are characteristic pulmonary function, radiographic, and histologic findings, but polysomnography (PSG) data has not been reported...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29759958/data-access-and-usage-practices-across-a-cohort-of-researchers-at-a-large-tertiary-pediatric-hospital-qualitative-survey-study
#5
Hoi Ki Kiki Ho, Matthias Görges, Elodie Portales-Casamar
BACKGROUND: Health and health-related data collected as part of clinical care is a foundational component of quality improvement and research. While the importance of these data is widely recognized, there are many challenges faced by researchers attempting to use such data. It is crucial to acknowledge and identify barriers to improve data sharing and access practices and ultimately optimize research capacity. OBJECTIVE: To better understand the current state, explore opportunities, and identify barriers, an environmental scan of investigators at BC Children's Hospital Research Institute (BCCHR) was conducted to elucidate current local practices around data access and usage...
May 14, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29751857/residency-mini-fellowships-in-the-pgy-5-year-is-there-added-value
#6
Anuradha S Shenoy-Bhangle, Ronald L Eisenberg, Tabitha Fineberg, Priscilla J Slanetz
RATIONALE AND OBJECTIVES: With the restructuring of radiology board certification, many residencies created PGY-5 "mini-fellowships," during which residents spend focused time pursuing advanced subspecialty training or developing nonclinical skills in leadership, health policy and health-care economics, education, quality improvement, informatics, research, or global health. We surveyed graduates of an academic diagnostic radiology residency to assess the relative value and impact of PGY-5 mini-fellowships on career satisfaction and success...
June 2018: Academic Radiology
https://www.readbyqxmd.com/read/29748851/a-platform-for-innovation-and-standards-evaluation-a-case-study-from-the-openmrs-open-source-radiology-information-system
#7
Judy W Gichoya, Marc Kohli, Larry Ivange, Teri S Schmidt, Saptarshi Purkayastha
Open-source development can provide a platform for innovation by seeking feedback from community members as well as providing tools and infrastructure to test new standards. Vendors of proprietary systems may delay adoption of new standards until there are sufficient incentives such as legal mandates or financial incentives to encourage/mandate adoption. Moreover, open-source systems in healthcare have been widely adopted in low- and middle-income countries and can be used to bridge gaps that exist in global health radiology...
May 10, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29741272/proton-pump-inhibitor-and-histamine-2-receptor-antagonist-use-and-risk-of-liver-cancer-in-two-population-based-studies
#8
K T Tran, Ú C McMenamin, B Hicks, P Murchie, A P Thrift, H G Coleman, L Iversen, B T Johnston, A J Lee, C R Cardwell
BACKGROUND: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are commonly used. PPIs have been shown to promote liver cancer in rats; however, only one study has examined the association in humans. AIMS: To investigate PPIs and H2RAs and risk of primary liver cancer in two large independent study populations. METHODS: We conducted a nested case-control study within the Primary Care Clinical Informatics Unit (PCCIU) database in which up to five controls were matched to cases with primary liver cancer, recorded by General Practitioners...
May 9, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29727589/genome-sequencing-in-the-clinic-the-past-present-and-future-of-genomic-medicine
#9
Jeremy W Prokop, Thomas May, Kim Strong, Stephanie M Bilinovich, Caleb Bupp, Surender Rajasekaran, Elizabeth A Worthey, Jozef Lazar
Genomic sequencing has undergone massive expansion in the past ten years, opening the door from being a rarely used research tool into an approach that has broad applications in a clinical setting. From rare disease to cancer, genomics is transforming our knowledge of biology. The transition from targeted gene sequencing, to whole exome sequencing, to whole genome sequencing has only been made possible due to rapid advancements in technologies and informatics that have plummeted the cost per base of DNA sequencing and analysis...
May 4, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29726441/how-to-measure-physical-motion-and-the-impact-of-individualized-feedback-in-the-field-of-rehabilitation-of-geriatric-trauma-patients
#10
Amelie Altenbuchner, Sonja Haug, Rainer Kretschmer, Karsten Weber
BACKGROUND: This preparatory study accelerates an implementation of individualized monitoring and feedback of physical motion using conventional motion trackers in the rehabilitation process of geriatric trauma patients. Regaining mobility is accompanied with improved quality of life in persons of very advanced age recovering from fragility fractures. OBJECTIVES: Quantitative survey of regaining physical mobility provides recommendations for action on how to use motion trackers effectively in a clinical geriatric setting...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29725963/patient-centered-radiology-with-fhir-an-introduction-to-the-use-of-fhir-to-offer-radiology-a-clinically-integrated-platform
#11
Peter I Kamel, Paul G Nagy
Fast Healthcare Interoperability Resources (FHIR) is an open interoperability standard that allows external software to quickly search for and access clinical information from the electronic medical record (EMR) in a method that is developer-friendly, using current internet technology standards. In this article, we highlight the new FHIR standard and illustrate how FHIR can be used to offer the field of radiology a more clinically integrated and patient-centered system, opening the EMR to external radiology software in ways unfeasible with traditional standards...
May 3, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29724442/informatics-solutions-for-application-of-decision-making-skills
#12
REVIEW
Christine W Nibbelink, Janay R Young, Jane M Carrington, Barbara B Brewer
Critical care nurses practice in a challenging environment that requires responses to patients with complex, often unstable health conditions. The electronic health record, access to clinical data, and Clinical Decision Support Systems informed by data from clinical databases are informatics tools designed to work together to facilitate decision-making in nursing practice. The complex decision-making environment of critical care requires informatics tools that support nursing practice through integration of current evidence with clinical data...
June 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29721362/career-paths-of-pathology-informatics-fellowship-alumni
#13
Joseph W Rudolf, Christopher A Garcia, Matthew G Hanna, Christopher L Williams, Ulysses G Balis, Liron Pantanowitz, J Mark Tuthill, John R Gilbertson
Background: The alumni of today's Pathology Informatics and Clinical Informatics fellowships fill diverse roles in academia, large health systems, and industry. The evolving training tracks and curriculum of Pathology Informatics fellowships have been well documented. However, less attention has been given to the posttraining experiences of graduates from informatics training programs. Here, we examine the career paths of subspecialty fellowship-trained pathology informaticians. Methods: Alumni from four Pathology Informatics fellowship training programs were contacted for their voluntary participation in the study...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29717934/understanding-leishmania-parasites-through-proteomics-and-implications-for-the-clinic
#14
Shyam Sundar, Bhawana Singh
Leishmania spp. are causative agents of leishmaniasis, a broad-spectrum neglected vector-borne disease. Genomic and transcriptional studies are not capable of solving intricate biological mysteries, leading to the emergence of proteomics, which can provide insights into the field of parasite biology and its interactions with the host. Areas covered: The combination of genomics and informatics with high throughput proteomics may improve our understanding of parasite biology and pathogenesis. This review analyses the roles of diverse proteomic technologies that facilitate our understanding of global protein profiles and definition of parasite development, survival, virulence and drug resistance mechanisms for disease intervention...
May 2, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29710185/accuracy-and-reliability-of-eye-based-vs-quadrant-based-diagnosis-of-plus-disease-in-retinopathy-of-prematurity
#15
Sang Jin Kim, J Peter Campbell, Jayashree Kalpathy-Cramer, Susan Ostmo, Karyn E Jonas, Dongseok Choi, R V Paul Chan, Michael F Chiang
Importance: Presence of plus disease in retinopathy of prematurity is the most critical element in identifying treatment-requiring disease. However, there is significant variability in plus disease diagnosis. In particular, plus disease has been defined as 2 or more quadrants of vascular abnormality, and it is not clear whether it is more reliably and accurately diagnosed by eye-based assessment of overall retinal appearance or by quadrant-based assessment combining grades of 4 individual quadrants...
April 26, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29701384/endothelial-function-and-vascular-properties-in-severe-aortic-stenosis-before-and-after-aortic-valve-replacement-surgery
#16
Renata Melo, Francisca A Saraiva, Ana Filipa Ferreira, Soraia Moreira, Raquel Moreira, Rui J Cerqueira, Mário J Amorim, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: The degenerative process that results in aortic valve stenosis (AS) has pathophysiological features similar to the atherosclerotic process. We therefore hypothesized that, as in atherosclerosis, endothelial and vascular dysfunction could be a pathophysiologic feature of AS. AIM: To evaluate endothelial function before and after aortic valve replacement (AVR) surgery in patients with severe AS. To correlate endothelial function with severity of AS and clinical profile...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701361/postoperative-atrial-fibrillation-after-coronary-artery-bypass-grafting-surgery
#17
Ana Filipa Ferreira, Francisca A Saraiva, Raquel Moreira, Rui J Cerqueira, Mário J Amorim, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: Postoperative atrial fibrillation (PoAF) is the most common arrhythmia following cardiac surgery, which increase the patient's morbidity and mortality. PURPOSE: The aim of this study was to evaluate new onset of atrial fibrillation (AF) after isolated coronary artery bypass grafting (CABG) surgery, its clinical and surgical predictors, and its impact in immediate and long-term outcomes. METHODS: Retrospective study including all CABG surgeries performed in a tertiary centre, between 2004 and 2011...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701359/cardiac-catheterization-after-cabg-with-bima-grafting-independent-predictors-and-mid-term-bypass-viability
#18
Francisca A Saraiva, Marta Tavares-Silva, Rui J Cerqueira, Mário J Amorim, Ana Filipa Ferreira, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: Coronary artery bypass graft (CABG) patency is an important variable, but rarely studied as the main outcome. The best use of bilateral internal mammary artery (BIMA) grafting regarding configuration type or combination with saphenous vein graft (SVG) is still debated. PURPOSE: To find independent predictors for need of cardiac catheterization and for significant lesions in CABG follow-up. METHODS: Retrospective cohort including all patients who underwent isolated CABG with BIMA grafts between 2004 and 2013 in a tertiary center...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29698836/system-for-informatics-in-the-molecular-pathology-laboratory-simpl-an-open-source-end-to-end-solution-for-next-generation-sequencing-clinical-data-management
#19
Wenjun Kang, Sabah Kadri, Rutika Puranik, Michelle N Wurst, Sushant A Patil, Ibro Mujacic, Sonia Benhamed, Nifang Niu, Chao Jie Zhen, Bekim Ameti, Bradley C Long, Filipo Galbo, David Montes, Crystal Iracheta, Venessa L Gamboa, Daisy Lopez, Michael Yourshaw, Carolyn A Lawrence, Dara L Aisner, Carrie Fitzpatrick, Megan E McNerney, Y Lynn Wang, Jorge Andrade, Samuel L Volchenboum, Larissa V Furtado, Lauren L Ritterhouse, Jeremy P Segal
Next-generation sequencing (NGS) diagnostic assays are increasingly becoming the standard of care in oncology practice. As the scale of an NGS laboratory grows, management of these assays requires organizing large amounts of information, including patient data, laboratory processes, genomic data, as well as variant interpretation and reporting. Although several Laboratory Information Systems (LIS) and/or Laboratory Information Management Systems (LIMS) are commercially available, they may not meet all of the needs of a given laboratory, in addition to being frequently cost prohibitive...
April 23, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29691211/developing-a-third-party-analytics-application-using-australia-s-national-personal-health-records-system-case-study
#20
Niranjan Bidargaddi, Yasmin van Kasteren, Peter Musiat, Michael Kidd
BACKGROUND: My Health Record (MyHR) is Australia's national electronic health record (EHR) system. Poor usability and functionality have resulted in low utility, affecting enrollment and participation rates by both patients and clinicians alike. Similar to apps on mobile phone app stores, innovative third-party applications of MyHR platform data can enhance the usefulness of the platform, but there is a paucity of research into the processes involved in developing third-party applications that integrate and use data from EHR systems...
April 24, 2018: JMIR Medical Informatics
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