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https://www.readbyqxmd.com/read/28431368/correlates-of-perceived-stigma-for-people-living-with-epilepsy-a-meta-analysis
#1
REVIEW
Ying Shi, Shouqi Wang, Jie Ying, Meiling Zhang, Pengcheng Liu, Huanhuan Zhang, Jiao Sun
OBJECTIVE: Epilepsy, one of the most common, serious chronic neurological diseases, is accompanied by different levels of perceived stigma that affects people in almost all age groups. This stigma can negatively impact the physical and mental health of people living with epilepsy (PLWE). Good knowledge of perceived stigma for PLWE is important. In this study, we conducted a meta-analysis to identify the correlates of perceived stigma for PLWE. METHODS: Studies on factors associated with perceived stigma for PLWE, including sociodemographic, psychosocial, and disease-related variables, were searched in PubMed, PsychINFO, EMBASE, and Web of Science...
April 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28426918/advanced-cancer-caregiving-as-a-risk-for-major-depressive-episodes-and-generalized-anxiety-disorder
#2
Kelly M Trevino, Holly G Prigerson, Paul K Maciejewski
OBJECTIVE: Caregivers of advanced cancer patients provide extensive care associated with high levels of caregiver distress. The degree to which cancer caregiving increases caregivers' risk for a psychiatric disorder is unknown. The current study examines whether advanced cancer caregiving poses distinct risks for initial and recurrent major depressive episodes (MDEs) and generalized anxiety disorder (GAD) relative to the general population. METHODS: Caregivers of advanced cancer patients (N = 540) from Coping with Cancer were compared to general population controls (N = 9,282) from the National Comorbidity Survey Replication...
April 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28426375/united-states-population-based-estimates-of-patient-reported-outcomes-measurement-information-system-symptom-and-functional-status-reference-values-for-individuals-with-cancer
#3
Roxanne E Jensen, Arnold L Potosky, Carol M Moinpour, Tania Lobo, David Cella, Elizabeth A Hahn, David Thissen, Ashley Wilder Smith, Jaeil Ahn, George Luta, Bryce B Reeve
Purpose To estimate cancer population-based reference values in the United States for eight PROMIS (Patient-Reported Outcomes Measurement Information System) domains by age and stage of disease. Patients and Methods For the Measuring Your Health (MY-Health) study, persons newly diagnosed with cancer (prostate, colorectal, non-small-cell lung, non-Hodgkin lymphoma, breast, uterine, or cervical) from 2010 to 2012 (N = 5,284) were recruited through the National Cancer Institute's SEER Program. Participants were mailed surveys 6 to 13 months after diagnosis...
April 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28421796/effect-of-satiety-on-body-composition-and-anxiety-in-university-athletes-cohort-study
#4
Alejandro Martínez-Rodríguez, Enrique Roche
BACKGROUND: Satiety is a determining parameter in nutrient intake control, which in the long run impacts on body weight. Many athletes need strict control on their weight to achieve their aims of the season. AIM: The aim of this study is to analyse the influence of satiety on body weight control and competitive anxiety in a university athletes population when they ingest ad libitum foods (SATIETY), or follow a nutritional dietary programme (DIET). METHODS: The present study was a cohort study, in which 40 male university athletes participated...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28412873/%C3%AE-3-adrenergic-receptors-adipokines-and-neuroendocrine-activation-during-stress-induced-by-repeated-immune-challenge-in-male-and-female-rats
#5
Agnesa Csanova, Natasa Hlavacova, Malgorzata Hasiec, Michal Pokusa, Barbora Prokopova, Daniela Jezova
The main hypothesis of the study is that stress associated with repeated immune challenge has an impact on β3-adrenergic receptor gene expression in the brain. Sprague-Dawley rats were intraperitoneally injected with increasing doses of lipopolysaccharide (LPS) for 5 consecutive days. LPS treatment was associated with body weight loss and increased anxiety-like behavior. In LPS-treated animals of both sexes, β3-receptor gene expression was increased in the prefrontal cortex but not the hippocampus. LPS treatment decreased β3-receptor gene expression in white adipose tissue with higher values in males compared to females...
April 16, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28412607/effect-of-early-postnatal-exposure-to-valproate-on-neurobehavioral-development-and-regional-bdnf-expression-in-two-strains-of-mice
#6
Kevin G Bath, Tiare Pimentel
Valproate has been used for over 30years as a first-line treatment for epilepsy. In recent years, prenatal exposure to valproate has been associated with teratogenic effects, limiting its use in women that are pregnant or of childbearing age. However, despite its potential detrimental effects on development, valproate continues to be prescribed at high rates in pediatric populations in some countries. Animal models allow us to test hypotheses regarding the potential effects of postnatal valproate exposure on neurobehavioral development, as well as identify potential mechanisms mediating observed effects...
April 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28411068/protective-effect-of-dapsone-on-cognitive-impairment-induced-by-propofol-involves-hippocampal-autophagy
#7
Ning Yang, Lunxu Li, Zhengqian Li, Cheng Ni, Yiyun Cao, Taotao Liu, Miao Tian, Dehua Chui, Xiangyang Guo
Post-operative cognitive dysfunction (POCD) is a commonly seen postoperative complication in elderly patients and its underlying mechanisms are still unclear. Autophagy, a degradation mechanism of cellular components, is required for cell survival and many physiological processes. Although propofol is one of the most commonly used intravenous anesthetics, investigations into its mechanisms and effects on cognition in aged rodents are relatively scarce. In this study, we evaluate the influence of propofol on learning and memory, and identify the potential role of hippocampal autophagy in propofol-induced cognitive alterations in aged rats...
April 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28410467/examination-of-the-interpersonal-model-of-loss-of-control-eating-in-the-laboratory
#8
Lisa M Shank, Ross D Crosby, Anne Claire Grammer, Lauren B Shomaker, Anna Vannucci, Natasha L Burke, Monika Stojek, Sheila M Brady, Merel Kozlosky, James C Reynolds, Jack A Yanovski, Marian Tanofsky-Kraff
BACKGROUND: The interpersonal model of loss of control (LOC) eating proposes that interpersonal problems lead to negative affect, which in turn contributes to the onset and/or persistence of LOC eating. Despite preliminary support, there are no data examining the construct validity of the interpersonal model of LOC eating using temporally sensitive reports of social stress, distinct negative affective states, and laboratory energy intake. METHOD: 117 healthy adolescent girls (BMI: 75th-97th %ile) were recruited for a prevention trial targeting excess weight gain in adolescent girls who reported LOC eating...
April 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28408072/nonmedical-use-of-prescription-opioids-among-pregnant-u-s-women
#9
Katy B Kozhimannil, Amy J Graves, Robert Levy, Stephen W Patrick
OBJECTIVES: Nonmedical use of opioids during pregnancy is associated with adverse outcomes for women and infants, making it a prominent target for prevention and identification. Using a nationally representative sample, we determined characteristics of U.S. pregnant women who reported prescription opioid misuse in the past year or during the past month. METHODS: We used data from the National Survey on Drug Use and Health (2005-2014) in a retrospective analysis...
March 31, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28404200/symptoms-and-patient-factors-associated-with-diagnostic-intervals-for-pancreatic-cancer-symptom-pancreatic-study-a-prospective-cohort-study
#10
Fiona M Walter, Katie Mills, Silvia C Mendonça, Gary A Abel, Bristi Basu, Nick Carroll, Sue Ballard, John Lancaster, William Hamilton, Greg P Rubin, Jon D Emery
BACKGROUND: Pancreatic cancer is the tenth most common cancer in the UK; however, outcomes are poor, in part due to late diagnosis. We aimed to identify symptoms and other clinical and sociodemographic factors associated with pancreatic cancer diagnosis and diagnostic intervals. METHODS: We did this prospective cohort study at seven hospitals in two regions in England. We recruited participants aged 40 years or older who were referred for suspicion of pancreatic cancer...
December 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28404069/patient-reported-outcomes-with-sofosbuvir-and-velpatasvir-with-or-without-ribavirin-for-hepatitis-c-virus-related-decompensated-cirrhosis-an-exploratory-analysis-from-the-randomised-open-label-astral-4-phase-3-trial
#11
Zobair M Younossi, Maria Stepanova, Michael Charlton, Michael P Curry, Jacqueline G O'Leary, Robert S Brown, Sharon Hunt
BACKGROUND: Hepatitis C virus (HCV) treatment regimens with direct-acting antivirals have not been extensively studied in patients with decompensated cirrhosis. We assessed patient-reported outcomes (PROs) in patients with decompensated cirrhosis given a fixed-dose combination of sofosbuvir and velpatasvir with and without ribavirin. METHODS: This study was an exploratory analysis of data collected in a randomised, open-label phase 3 trial (ASTRAL-4) in which patients with HCV-related decompensated cirrhosis were randomly assigned to an all-oral fixed-dose combination of sofosbuvir (400 mg) and velpatasvir (100 mg) once daily for 12 weeks, sofosbuvir and velpatasvir plus oral ribavirin (weight-based 1000 mg or 1200 mg) for 12 weeks, or sofosbuvir and velpatasvir for 24 weeks...
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403933/knocking-down-amygdalar-ptp1b-in-diet-induced-obese-rats-improves-insulin-signaling-action-decreases-adiposity-and-may-alter-anxiety-behavior
#12
Natalia Ferreira Mendes, Gisele Castro, Dioze Guadagnini, Natalia Tobar, Susana Quiros Cognuck, Lucila Leico Kagohara Elias, Patricia Aline Boer, Patricia Oliveira Prada
OBJECTIVE: Protein tyrosine phosphatase 1B (PTP1B) has been extensively implicated in the regulation of body weight, food intake, and energy expenditure. The role of PTP1B appears to be cell and brain region dependent. RESULTS: Herein, we demonstrated that chronic high-fat feeding enhanced PTP1B expression in the central nucleus of the amygdala (CeA) of rats compared to rats on chow. Knocking down PTP1B with oligonucleotide antisense (ASO) decreased its expression and was sufficient to improve the anorexigenic effect of insulin through IR/Akt signaling in the CeA...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28402986/no-small-matter-pediatric-resuscitation
#13
Taylor McCormick, Kevin McVaney, Paul E Pepe
PURPOSE OF REVIEW: To present advancements in pediatric cardiac arrest research, highlighting articles most relevant to clinical practice published since the latest international guidelines for cardiopulmonary resuscitation (CPR). RECENT FINDINGS: Clinical trials examining targeted temperature management in children support avoidance of hyperthermia for both pediatric in-hospital cardiac arrest (PIHCA) and out-of-hospital cardiac arrest (POHCA), but no statistically significant outcome differences were confirmed comparing 33 and 36 °C in the limited populations studied...
April 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28401689/progressive-resistance-training-prt-improves-rheumatoid-arthritis-outcomes-a-district-general-hospital-dgh-model
#14
Klara Morsley, Berna Berntzen, Lisa Erwood, Toby Bellerby, Lyn Williamson
OBJECTIVE: Rheumatoid cachexia is common in rheumatoid arthritis (RA) patients and develops soon after diagnosis, despite adequate drug therapy. It is associated with multiple adverse effects on body composition, function and mortality. Progressive resistance training (PRT) improves these outcomes but is not widely prescribed outside of a research setting. The aim of the present study was to explore the practicality and effectiveness of providing PRT to patients in a district general hospital within the constraints of existing resources...
April 12, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28399791/highly-palatable-food-access-during-adolescence-increased-anxiety-depression-like-behaviors-in-male-but-not-in-female-rats
#15
Jin Young Kim, Doyun Kim, Kyungpyo Park, Jong-Ho Lee, Jeong Won Jahng
OBJECTIVES: This study was conducted to examine the sexual dimorphic effects of highly palatable food (HPF) access during adolescence on the neurochemistry and depression-/anxiety-like behaviors of rats. METHODS: Male and female Sprague-Dawley pups had free access to chocolate cookie rich in fat (HPF) from postnatal day 28 in addition to ad libitum chow, and the control groups received only chow. The food conditions were continued throughout the entire experimental period, and the neurochemical and behavioral measurements were performed during young adulthood...
April 11, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28394647/creating-an-opportunity-to-reflect-ear-acupuncture-in-anorexia-nervosa-inpatients-experiences
#16
Siiri Hedlund, Kajsa Landgren
The aim of this study was to elucidate the meaning of receiving acupuncture as a complement in the treatment of anorexia nervosa at a specialist unit. Nine inpatients were interviewed, one to three times. The sixteen interviews were analysed with a phenomenological hermeneutic method. The main theme found was "Creating a pause, a framework for rest and reflection." The participants described acupuncture to be an attractive part of the treatment, offering a pause in a very stressful situation. The relaxing effect was palpable...
April 10, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28390969/environmental-enrichment-reduces-chronic-psychosocial-stress-induced-anxiety-and-ethanol-related-behaviors-in-mice
#17
Amine Bahi
Previous research from our laboratory has shown that exposure to chronic psychosocial stress increased voluntary ethanol consumption and preference as well as acquisition of ethanol-induced conditioned place preference (CPP) in mice. This study was done to determine whether an enriched environment could have "curative" effects on chronic psychosocial stress-induced ethanol intake and CPP. For this purpose, experimental mice "intruders" were exposed to the chronic subordinate colony (CSC) housing for 19 consecutive days in the presence of an aggressive "resident" mouse...
April 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28390006/psychometric-properties-of-the-weight-self-stigma-questionnaire-wssq-among-a-sample-of-overweight-obese-french-speaking-adolescents
#18
Christophe Maïano, Annie Aimé, Geneviève Lepage, Alexandre J S Morin
PURPOSE: The Weight Self-Stigma Questionnaire (WSSQ) was recently developed to assess the internalization of weight stigma among English-speaking overweight and obese adults. The objective of the present study was to develop and examine the psychometric properties of a French version of the WSSQ, as well as its applicability to adolescents. METHODS: The sample comprised 156 overweight and obese adolescents (81 boys, 75 girls, M age = 16.31). The factor validity and the convergent validity of the French version of the WSSQ were examined using a confirmatory factor analysis and a structural equation model, respectively...
April 7, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28389340/genetic-predisposition-to-obesity-affects-behavioural-traits-including-food-reward-and-anxiety-like-behaviour-in-rats
#19
Heike Vogel, Maria Kraemer, Cristina Rabasa, Kaisa Askevik, Roger A H Adan, Suzanne L Dickson
Here we sought to define behavioural traits linked to anxiety, reward, and exploration in different strains of rats commonly used in obesity research. We hypothesized that genetic variance may contribute not only to their metabolic phenotype (that is well documented) but also to the expression of these behavioural traits. Rat strains that differ in their susceptibility to develop an obese phenotype (Sprague-Dawley, Obese Prone, Obese Resistant, and Zucker rats) were exposed to a number of behavioural tests starting at the age of 8 weeks...
April 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28386912/neuropsychiatric-safety-with-liraglutide-3-0%C3%A2-mg-for-weight-management-results-from-randomized-controlled-phase-2-and-3a-trials
#20
P M O'Neil, V R Aroda, A Astrup, R Kushner, D C W Lau, T A Wadden, J Brett, A Cancino, J P H Wilding
AIMS: Liraglutide, a GLP-1 receptor agonist, regulates appetite via receptors in the brain. Due to concerns over the potential of centrally-acting anti-obesity medications to affect mental health, pooled neuropsychiatric safety data from all phase 2 and 3a randomized, double-blind trials with liraglutide 3.0 mg were evaluated post hoc. METHODS: Data from the liraglutide weight-management programme were pooled. Across trials, individuals with a body mass index ≥30 kg/m(2) or ≥27 kg/m(2) with weight-related comorbidities were randomized to once-daily subcutaneous liraglutide 3...
April 6, 2017: Diabetes, Obesity & Metabolism
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