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https://www.readbyqxmd.com/read/29138656/-hyperthyroidism-in-children-at-the-university-hospital-in-dakar-senegal
#1
Djibril Boiro, Demba Diédhiou, Babacar Niang, Djiby Sow, Mandiaye Mbodj, Anna Sarr, Aliou Abdoulaye Ndongo, Aliou Thiongane, Modou Guèye, Lamine Thiam, Ndiogou Seck, Yaay Joor Dieng, Abou Ba, Idrissa Demba Ba, Ibrahima Mané Diallo, Ousmane Ndiaye, Said Nourou Diop
Introduction: Hyperthyroidism in children is rare and constitutes a problem because of its psychosomatic impact. This study aimed to present an overview of the state of knowledge on these aspects in children from Dakar. Methods: We conducted a multicenter, descriptive study over a period of 15 years. We evaluated the epidemiological, clinical and etiologic aspects of hyperthyroidism in children. Results: 239 patients were included in the study with a prevalence of 2...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29133383/structured-education-programme-for-women-with-polycystic-ovary-syndrome-a-randomised-controlled-trial
#2
Hamidreza Mani, Yogini Chudasama, Michelle Hadjiconstantinou, Daniel H Bodicoat, Charlotte Edwardson, Miles Levy, Laura J Gray, Janette Barnett, Heather Daly, Trevor A Howlett, Kamlesh Khunti, Melanie J Davies
OBJECTIVE: To evaluate the effectiveness of a structured education programmes in women with polycystic ovary syndrome (PCOS). METHODS: Single centre, randomised controlled trial, testing a single exposure to a group-based, face-to-face, structured education programme. Inclusion criteria were women with PCOS, aged 18-49 years inclusive and Body Mass Index ≥ 23 kg/m2 for Black and Minority Ethnicities or ≥ 25 kg/m2 for White Europeans. Primary outcome was step count/day at 12 months...
November 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29130290/parent-patient-and-health-professional-perspectives-regarding-enteral-nutrition-in-paediatric-oncology
#3
Jennifer Cohen, Claire E Wakefield, Linda C Tapsell, Karen Walton, Richard J Cohn
AIM: Enteral tube feeding (ETF) is an important part of treatment for paediatric cancer patients. Without nutritional therapy, the prevalence of under-nutrition during treatment for childhood cancer may be as high as 50%. To ensure that the appropriate initiation of ETF is optimised, information on the views of key stakeholders regarding ETF is needed. METHODS: In total, 48 interviews were conducted with parents of paediatric cancer patients (n = 20), patients (n = 10) and members of the paediatric oncology health-care team (n = 18)...
November 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29127577/predictors-of-success-in-bariatric-surgery-the-role-of-bmi-and-pre-operative-comorbidities
#4
Magda Rosa Ramos da Cruz, Alcides José Branco-Filho, Marília Rizzon Zaparolli, Nathalia Farinha Wagner, José Simão de Paula Pinto, Antônio Carlos Ligocki Campos, Cesar Augusto Taconeli
BACKGROUND: This is a retrospective review of 204 patients who underwent bariatric surgery. The impact of weight regain (WR), pre-operative comorbidities and BMI values on the recurrence of comorbidities was evaluated, and an equation was elaborated to estimate BMI at 5 years of bariatric surgery. METHODS: Pre-operative data, after 1 year and after 5 years, was collected from the medical records. Descriptive analyses and bivariate hypothesis tests were performed first, and then, a generalised linear regression model with Tweedie distribution was adjusted...
November 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29125223/perinatal-nutrition-interacts-with-genetic-background-to-alter-behavior-in-a-parent-of-origin-dependent-manner-in-adult-collaborative-cross-mice
#5
S A Schoenrock, D Oreper, J Farrington, R C McMullan, R Ervin, D R Miller, F Pardo-Manuel de Villena, W Valdar, L M Tarantino
Previous studies in animal models and humans have shown that exposure to nutritional deficiencies in the perinatal period increases the risk of psychiatric disease. Less well understood is how such effects are modulated by the combination of genetic background and parent-of-origin. To explore this, we exposed female mice from 20 Collaborative Cross (CC) strains to either protein deficient, vitamin D deficient, methyl donor enriched or standard diet during the perinatal period. These CC females were then crossed to a male from a different CC strain to produce reciprocal F1 hybrid females comprising 10 distinct genetic backgrounds...
November 10, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29124972/perinatal-and-familial-risk-factors-for-irritable-bowel-syndrome-in-a-swedish-national-cohort
#6
Rasmus Waehrens, Xinjun Li, Jan Sundquist, Kristina Sundquist, Bengt Zöller
OBJECTIVE: Studies of the importance of perinatal factors for the development of irritable bowel syndrome (IBS) are sparse. We conducted a large national cohort study to examine perinatal and familial risk factors for IBS. MATERIAL AND METHODS: A national cohort of 1,963,685 persons who were born in Sweden in 1973-1992 (identified from the Swedish Birth Registry) were followed up for adult (18 years and older) IBS incidence in the Swedish Patient Register through 2010 (maximum age 38 years)...
November 10, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29124398/patient-perceptions-of-glucocorticoids-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#7
Joanna C Robson, Jill Dawson, Peter F Cronholm, Susan Ashdown, Ebony Easley, Katherine S Kellom, Don Gebhart, Georgia Lanier, Nataliya Milman, Jacqueline Peck, Raashid A Luqmani, Judy A Shea, Gunnar Tomasson, Peter A Merkel
Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) are multisystem diseases of small blood vessels, collectively known as the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). This study explores the patient's perspective on the use of glucocorticoids, which are still a mainstay of treatment in AAV. Patients with AAV from the UK, USA, and Canada were interviewed, using purposive sampling to include a range of disease manifestations and demographics...
November 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29119931/extend-pathomechanism-and-clinical-consequences-of-brain-volume-changes-in-anorexia-nervosa
#8
Jochen Seitz, Kerstin Konrad, Beate Herpertz-Dahlmann
INTRODUCTION: Brain volume deficits of grey (GM) and white matter (WM) are often found in patients with anorexia nervosa (AN). However, until recently, little was known about the influencing factors of these brain volume alterations, nor their exact quantification and rehabilitation. METHODS: This review addresses these open questions and further explores what is now known about the underlying pathobiology and the clinical consequences including human studies as well as animal studies mimicking anorexia nervosa in rodents...
November 9, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29118713/corticotropin-releasing-factor-in-the-bed-nucleus-of-the-stria-terminalis-in-socially-defeated-and-non-stressed-mice-with-a-history-of-chronic-alcohol-intake
#9
Lucas Albrechet-Souza, Thiago W Viola, Rodrigo Grassi-Oliveira, Klaus A Miczek, Rosa M M de Almeida
Stress exposure has been identified as one risk factor for alcohol abuse that may facilitate the transition from social or regulated use to the development of alcohol dependence. Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption. The bed nucleus of the stria terminalis (BNST) contains CRF-producing neurons which seem to be sensitive to stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29114198/depression-led-pitting-edema-a-rarest-case-presentation
#10
Niraj Khatri Sapkota
Pitting edema is the clinical manifestation generally presented due to long standing, especially during summer in the sun, heavy weight bearing, vasodilatation, or cardio-hepatorenal disease or in rare hypothyroidism, but in atypical case may demonstrates depression with progressive stress, that also shows indication of mild pitting edema. We present a case of a non-alcoholic 42 years divorced male under anti-anxiety medication for 10 years who complained of weight gain almost 10 kg in 30 days duration, less attentive to his work, and always feel sleepiness during day (once get to sleep, slept more than 5 h during day) and also late up to morning if not called to wake-up, also with diminished memory, more specific event was before 60 days of these symptoms he unexpectedly suffered family tragedy suggesting depression led progressive stress pitting edema that got managed after appropriate counseling along with changes in his life style...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29112884/appearance-based-rejection-sensitivity-as-a-mediator-of-the-relationship-between-symptoms-of-social-anxiety-and-disordered-eating-cognitions-and-behaviors
#11
Jake Linardon, Rachel Braithwaite, Rachel Cousins, Leah Brennan
Previous research has established a robust relationship between symptoms of social anxiety and disordered eating. However, the mechanisms that may underpin this relationship are unclear. Appearance-based rejection sensitivity (ABRS)-the tendency to anxiously expect and overreact to signs of appearance-based rejection-may be a crucial explanatory mechanism, as ABRS has been shown to maintain social anxiety symptoms and predict disordered eating. We therefore tested whether ABRS mediated the relationship between social anxiety symptoms and various indices of disordered eating (over-evaluation of weight/shape, restraint, binge eating, compulsive exercise, and vomiting)...
October 31, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29109060/cannabinoid-1-receptor-neutral-antagonist-reduces-binge-like-alcohol-consumption-and-alcohol-induced-accumbal-dopaminergic-signaling
#12
Andrea Balla, Bin Dong, Borehalli M Shilpa, Kiran Vemuri, Alexandros Makriyannis, Subhash C Pandey, Henry Sershen, Raymond F Suckow, K Yaragudri Vinod
Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously shown to be effective for nicotine cessation and obesity. However, studies using rimonabant were discontinued as it was associated with an increased risk of depression and anxiety. In the present study, we examined the pharmacokinetics and effects of AM4113, a novel CB1 receptor neutral antagonist on binge-like ethanol drinking in C57BL/6J mice using a two-bottle choice drinking-in-dark (DID) paradigm...
November 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29107289/disruption-of-the-homeodomain-transcription-factor-orthopedia-homeobox-otp-is-associated-with-obesity-and-anxiety
#13
Lee Moir, Elena G Bochukova, Rebecca Dumbell, Gareth Banks, Rasneer S Bains, Patrick M Nolan, Cheryl Scudamore, Michelle Simon, Kimberly A Watson, Julia Keogh, Elana Henning, Audrey Hendricks, Stephen O'Rahilly, Inês Barroso, Adrienne E Sullivan, David C Bersten, Murray L Whitelaw, Susan Kirsch, Elizabeth Bentley, I Sadaf Farooqi, Roger D Cox
OBJECTIVE: Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. METHODS: In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part of a dominant N-ethyl-N-nitrosourea (ENU) mutagenesis screen. We characterized the metabolic and behavioral phenotype of obese mutant mice and examined changes in hypothalamic gene expression...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29096284/psychosocial-predictors-of-gestational-weight-gain-and-the-role-of-mindfulness
#14
Jeni Matthews, Jennifer Huberty, Jenn Leiferman, Matthew Buman
OBJECTIVE: To identify the psychosocial factors (i.e., stress, anxiety, depression, social support) that are associated with gestational weight gain (GWG) and the relationship of mindfulness with GWG during each trimester of pregnancy. DESIGN: In this cross-sectional study, an online survey that assessed physical and mental health and wellness practices was administered to pregnant women. PARTICIPANTS: Pregnant women ≥8 weeks gestation, ≥18 years old, and could read and write in English...
October 16, 2017: Midwifery
https://www.readbyqxmd.com/read/29093454/a-novel-peptide-that-improves-metabolic-parameters-without-adverse-central-nervous-system-effects
#15
Patrícia Reckziegel, William T Festuccia, Luiz R G Britto, Karen L Lopes Jang, Carolina M Romão, Joel C Heimann, Manoela V Fogaça, Naielly S Rodrigues, Nicole R Silva, Francisco S Guimarães, Rosangela A S Eichler, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Andrea S Heimann, Emer S Ferro
Intracellular peptides generated by limited proteolysis are likely to function inside and outside cells and could represent new possibilities for drug development. Here, we used several conformational-sensitive antibodies targeting G-protein coupled receptors to screen for novel pharmacological active peptides. We find that one of these peptides, DITADDEPLT activates cannabinoid type 1 receptors. Single amino acid modifications identified a novel peptide, DIIADDEPLT (Pep19), with slightly better inverse agonist activity at cannabinoid type 1 receptors...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093280/satisfaction-and-efficacy-of-switching-from-daily-dipeptidyl-peptidase-4-inhibitors-to-weekly-trelagliptin-in-patients-with-type-2-diabetes-randomized-controlled-study
#16
Mayuko Oita, Hideaki Miyoshi, Kota Ono, Akinobu Nakamura, Kyu Yong Cho, Hiroshi Nomoto, Kohei Yamamoto, Kazuno Omori, Naoki Manda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi
We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4 inhibitors for more than 3 months. Patients were randomly assigned to a treatment cohort: (1) a group that continued taking daily DPP-4 inhibitors (daily group); or (2) a group that switched from daily DPP-4 inhibitors to a weekly DPP-4 inhibitor, trelagliptin (weekly group)...
October 31, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29092785/effects-of-cb1-receptor-antagonism-and-stress-exposures-in-adolescence-on-socioemotional-behaviours-neuroendocrine-stress-responses-and-expression-of-relevant-proteins-in-the-hippocampus-and-prefrontal-cortex-in-rats
#17
Jonathan J Simone, Jennet L Baumbach, Cheryl M McCormick
Little is known about the consequences of altered endocannabinoid signalling in adolescence. We hypothesized that CB1 receptor antagonism (AM251, 1 mg/kg) and stress exposures (1 h confinement stress) in adolescence (daily, postnatal days 30-44) would interact to increase neuroendocrine stress responses and anxiety when investigated a minimum of 24 h after drug and stress treatments; these treatment effects were independent of each other. Changes in homecage behaviour and in weight gain confirmed that both males and females were sensitive to the treatments...
October 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29091282/correlation-between-maternal-anxiety-reactivity-of-fetal-cerebral-circulation-to-auditory-stimulation-and-birth-outcome-in-normotensive-and-gestational-hypertensive-women
#18
Marina Vujović, Mirjana Sovilj, Ljiljana Jeličić, Miodrag Stokić, Darko Plećaš, Snežana Plešinac, Nadežda Nedeljković
This study investigated the correlation between maternal anxiety and blood flow changes through the fetal middle cerebral artery (MCA) after defined acoustic stimulation in 43 normotensive (C) and 40 gestational hypertensive (GH) subjects. Neonatal outcomes (gestational age at birth, Apgar score, birth weight) in the C and GH groups were analyzed. State (STAI-S) and trait (STAI-T) anxiety was assessed using Spielberger's questionnaire. The MCA blood flow was assessed once between 28 and 41 weeks of gestation using color Doppler ultrasound before and after application of defined acoustic stimulus...
November 1, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29090684/neuroactive-steroids-and-affective-symptoms-in-women-across-the-weight-spectrum
#19
Laura E Dichtel, Elizabeth A Lawson, Melanie Schorr, Erinne Meenaghan, Margaret Lederfine Paskal, Kamryn T Eddy, Graziano Pinna, Marianela Nelson, Ann M Rasmusson, Anne Klibanski, Karen K Miller
3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABAA receptor allosteric modulators. Both anorexia nervosa (AN) and obesity are complicated by affective co-morbidities and hypothalamic-pituitary-gonadal dysregulation. However, it is not known whether neuroactive steroid levels are abnormal at the extremes of the weight spectrum. We hypothesized that serum allopregnanolone and 3α-androstanediol levels would be decreased in AN compared to healthy controls (HC) and negatively associated with affective symptoms throughout the weight spectrum, independent of body mass index (BMI)...
November 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29082026/prevalence-of-anxiety-depression-and-post-traumatic-stress-disorder-in-the-kashmir-valley
#20
Tambri Housen, Annick Lenglet, Cono Ariti, Showkat Shah, Helal Shah, Shabnum Ara, Kerri Viney, Simon Janes, Giovanni Pintaldi
BACKGROUND: Following the partition of India in 1947, the Kashmir Valley has been subject to continual political insecurity and ongoing conflict, the region remains highly militarised. We conducted a representative cross-sectional population-based survey of adults to estimate the prevalence and predictors of anxiety, depression and post-traumatic stress disorder (PTSD) in the 10 districts of the Kashmir Valley. METHODS: Between October and December 2015, we interviewed 5519 out of 5600 invited participants, ≥18 years of age, randomly sampled using a probability proportional to size cluster sampling design...
2017: BMJ Global Health
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