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https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#1
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944574/a-novel-approach-for-intra-operative-shape-acquisition-of-the-tibio-femoral-joints-using-3d-laser-scanning-in-computer-assisted-orthopaedic-surgery
#2
Shailesh V Joshi, Philip J Rowe
BACKGROUND: Image registration (IR) is an important process of developing a spatial relationship between pre-operative data and the physical patient in the operation theatre. Current IR techniques for Computer Assisted Orthopaedic Surgery (CAOS) are time consuming and costly. There is a need to automate and accelerate this process. METHODS: Bespoke quick, cost effective, contactless and automated 3D laser scanning techniques based on the DAVID Laserscanner method were designed...
September 24, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28944404/differential-expression-of-genes-and-differentially-perturbed-pathways-associated-with-very-high-evening-fatigue-in-oncology-patients-receiving-chemotherapy
#3
Elena Flowers, Christine Miaskowski, Yvette Conley, Marilyn J Hammer, Jon Levine, Judy Mastick, Steven Paul, Fay Wright, Kord Kober
PURPOSE: Fatigue is the most common symptom associated with cancer and its treatment. Investigation of molecular mechanisms associated with fatigue in oncology patients may identify new therapeutic targets. The objectives of this study were to evaluate the relationships between gene expression and perturbations in biological pathways and evening fatigue severity in oncology patients who received chemotherapy (CTX). METHODS: The Lee Fatigue Scale (LFS) and latent class analysis were used to identify evening fatigue phenotypes...
September 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28943219/hyperhomocysteinemia-as-a-risk-factor-for-saccular-intracranial-aneurysm-a-cohort-study-in-a-chinese-han-population
#4
Jin-Rui Ren, Shao-Hua Ren, Bo Ning, Jun Wu, Yong Cao, Xin-Min Ding, Zi-Gang Zhen, Xu-Dong Hao, Shuo Wang
BACKGROUND: We evaluated the possible relationships between serum total homocysteine and folate and Vitamin B12 in patients with intracranial aneurysm. METHODS: We enrolled consecutive patients with intracranial aneurysm from the Han population who were admitted to the hospital, as well as control subjects who received medical examination on an outpatient basis. The serum total homocysteine, folate, and Vitamin B12 levels were measured in patients with intracranial aneurysm and the control group, and the associations between those factors were analyzed using multivariate logistic analysis...
September 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28942774/evaluation-of-patient-and-family-outpatient-complaints-as-a-strategy-to-prioritize-efforts-to-improve-cancer-care-delivery
#5
Jennifer W Mack, Joseph Jacobson, David Frank, Angel M Cronin, Kathleen Horvath, Victoria Allen, Jennifer Wind, Deborah Schrag
BACKGROUND: Limited systematic data about complaints related to cancer care are available. Patient complaints related to ambulatory care at a large academic cancer center were examined to better understand patient experiences of care and prioritize opportunities for quality improvement. METHODS: Content analysis of outpatient complaints made to the Patient/Family Relations Office at Dana-Farber Cancer Institute, Boston, in a two-year period (January 2013-December 2014) were conducted...
October 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28942704/why-people-who-inject-drugs-voluntarily-transition-off-methadone-in-ukraine
#6
Julia Rozanova, Ruthanne Marcus, Faye S Taxman, Martha J Bojko, Lynn Madden, Scott O Farnum, Alyona Mazhnaya, Sergii Dvoriak, Frederick L Altice
Methadone maintenance therapy (MMT) treats opioid use disorder among people who inject drugs (PWID). To understand why PWID may voluntarily discontinue MMT, we analyzed data from 25 focus groups conducted in five Ukrainian cities from February to April 2013 with 199 participants who were currently, previously, or never on MMT. Using constant comparison method, we uncovered three themes explaining why PWID transition off MMT: (a) purposeful resistance to rigid social control associated with how MMT is delivered and to power asymmetries in provider-patient relationships, (b) self-management of a PWID's "wounded identity" that is common in socially stigmatized and physically sick persons-MMT serves as a reminder of their illness, and (c) the quest for a "normal life" uninterrupted by daily MMT site visits, harassment, and time inefficiencies, resources, and social capital...
September 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28942481/high-resolution-vessel-wall-mri-for-the-evaluation-of-intracranial-atherosclerotic-disease
#7
REVIEW
Adam de Havenon, Mahmud Mossa-Basha, Lubdha Shah, Seong-Eun Kim, Min Park, Dennis Parker, J Scott McNally
High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology...
September 23, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28942390/imaging-for-structural-heart-procedures-focus-on-computed-tomography
#8
John Mooney, Stephanie L Sellers, Mickaël Ohana, João L Cavalcante, Chesnal D Arepalli, Rominder Grover, Ung Kim, Kapilan Selvakumar, Philipp Blanke, Jonathon A Leipsic
The success and continued rapid clinical integration of transcatheter valve technologies relies on imaging modalities to guide safe and effective device deployment. In particular, cardiac imaging, using both echocardiography and CT, is an integral resource for the multidisciplinary team. These modalities can provide valuable insight for the proceduralist at each stage of transcatheter-based valve insertion, as they can be used reliably to define the anatomy of interest and its relationship to surrounding structures, determine accurate device sizing, assess patients for valve-in-valve procedures, and screen for adverse features or procedural contraindications...
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28942041/quality-of-life-following-road-traffic-injury-a-systematic-literature-review
#9
Ritva Rissanen, Hans-Yngve Berg, Marie Hasselberg
PURPOSE: To assess and provide a systematic overview of current knowledge about the relationship between quality of life (QoL) and road traffic injury, and to appraise how QoL is affected by road traffic injury. METHODS: A systematic review of the literature published since 1990 on QoL after a road traffic injury, including adult and paediatric populations, from three databases (Pubmed, PsychInfo and SafetyLit) was undertaken. The methodological quality was assessed according to the Newcastle-Ottawa Quality Assessment Scale...
September 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28942011/end-tidal-carbon-dioxide-and-defibrillation-success-in-out-of-hospital-cardiac-arrest
#10
Simone Savastano, Enrico Baldi, Maurizio Raimondi, Alessandra Palo, Mirko Belliato, Elisa Cacciatore, Valentina Corazza, Simone Molinari, Fabrizio Canevari, Aurora I Danza, Giorgio Antonio Iotti, Luigi Oltrona Visconti
PURPOSE: Basing on the relationship between the quality of cardiopulmonary resuscitation (CPR) and the responsiveness of VF to the defibrillation we aimed to assess whether the values of ETCO2 in the minute before defibrillation could predict the effectiveness of the shock. MATERIALS AND METHODS: We retrospectively evaluated the reports generated by the manual monitor/defibrillator (Corpuls by GS Elektromedizinische Geräte G. Stemple GmbH, Germany) used for cases of VF cardiac arrest from January 2015 to December 2016...
September 20, 2017: Resuscitation
https://www.readbyqxmd.com/read/28941768/lateralization-effects-on-functional-connectivity-of-the-auditory-network-in-patients-with-unilateral-pulsatile-tinnitus-as-detected-by-functional-mri
#11
Han Lv, Pengfei Zhao, Zhaohui Liu, Xuehuan Liu, Heyu Ding, Liheng Liu, Guopeng Wang, Jing Xie, Rong Zeng, Yuchen Chen, Zhenghan Yang, Shusheng Gong, Zhenchang Wang
Unilateral pulsatile tinnitus (PT) was proved to be a kind of disease with brain functional abnormalities within and beyond the auditory network (AN). However, changes in patterns of the lateralization effects of PT are yet to be established. Relationship between the AN and other brain networks in PT patients is also a scientific question need to be answered. In this study, we recruited 23 left-sided, 23 right-sided PT (LSPT, RSPT) patients and 23 normal controls (NC). We combined applied independent component analysis and seed-based functional connectivity (FC) analysis to investigate alteration feature of the FC of the AN by using resting-state functional magnetic resonance imaging (rs-fMRI)...
September 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28941749/efficacy-of-a-transition-clinic-on-hospital-readmissions
#12
Vidya Chakravarthy, Mary J Ryan, Amir Jaffer, Robyn Golden, Regina McClenton, Jisu Kim, Irwin Press, Tricia Johnson
BACKGROUND: A primary care staffed transition clinic is one potential strategy for reducing thirty-day readmissions for patients without an established primary care physician, but the effectiveness has not been studied. The objective was to test whether patients who completed a post-discharge transition clinic appointment were less likely to be readmitted within thirty days. METHODS: This retrospective cross-sectional study included adults with Medicare and Medicaid coverage who were discharged from general medicine units at Rush University Medical Center between October 2013 and October 2014...
September 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28941623/post-licensure-safety-surveillance-study-of-routine-use-of-quadrivalent-meningococcal-diphtheria-toxoid-conjugate-vaccine
#13
J Hansen, L Zhang, N P Klein, C A Robertson, M D Decker, D P Greenberg, E Bassily, R Baxter
BACKGROUND: Menactra® vaccine (MenACWY-D) was licensed in the United States in 2005 for persons 11-55years of age. The aim of this study was to assess the safety of MenACWY-D administered as part of routine clinical care to patients at Kaiser Permanente Northern California (KPNC). METHODS: This was an observational, retrospective study that included all KPNC members who received MenACWY-D during the study period. We monitored all vaccine recipients for non-elective hospitalizations, emergency department visits, and selected outcomes captured in the clinic setting (Bell's palsy, seizures, neuritis, Guillain-Barré syndrome, encephalopathy, encephalitis, epilepsy, transverse myelitis, multiple sclerosis, hypersensitivity reactions, idiopathic thrombocytopenic purpura, diabetes, arthritis, hemolytic anemia, collagen-vascular disease) through 6months after vaccination...
September 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28941512/eyelid-and-periorbital-soft-tissue-trauma
#14
REVIEW
Audrey C Ko, Kellie R Satterfield, Bobby S Korn, Don O Kikkawa
Facial trauma often involves injuries to the eyelid and periorbital region. Management of these injuries can be challenging due to the involvement of multiple complex anatomic structures that are in close proximity. Restoration of normal anatomic relationships of the eyelids and periocular structures is essential for optimum functional and aesthetic outcome after trauma. This review provides an overview of the current literature involving soft tissue trauma of the eyelid and periorbital tissue, and highlights key steps in patient evaluation and management with various types of injuries...
November 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28940998/more-than-just-side-effects-the-role-of-clinical-and-psychosocial-factors-in-non-adherence-to-tamoxifen
#15
Zoe Moon, Rona Moss-Morris, Myra S Hunter, Lyndsay D Hughes
OBJECTIVES: Tamoxifen non-adherence is apparent in up to half of breast cancer survivors and is associated with increased risk of recurrence and reduced quality of life. However, factors contributing to non-adherence in this population are currently poorly understood. This study explored the relationship between key components of the Common Sense Model of Illness Representations (CSM)/the Theory of Planned Behaviour (TPB) and intentional and unintentional non-adherence in a large sample of women prescribed tamoxifen following primary breast cancer...
September 22, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28939432/characterizing-dynamic-amplitude-of-low-frequency-fluctuation-and-its-relationship-with-dynamic-functional-connectivity-an-application-to-schizophrenia
#16
REVIEW
Zening Fu, Yiheng Tu, Xin Di, Yuhui Du, G D Pearlson, J A Turner, Bharat B Biswal, Zhiguo Zhang, V D Calhoun
The human brain is a highly dynamic system with non-stationary neural activity and rapidly-changing neural interaction. Resting-state dynamic functional connectivity (dFC) has been widely studied during recent years, and the emerging aberrant dFC patterns have been identified as important features of many mental disorders such as schizophrenia (SZ). However, only focusing on the time-varying patterns in FC is not enough, since the local neural activity itself (in contrast to the inter-connectivity) is also found to be highly fluctuating from research using high-temporal-resolution imaging techniques...
September 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28939410/human-cd40l-expressing-type-3-innate-lymphoid-cells-induce-il-10-producing-immature-transitional-regulatory-b-cells
#17
Zsolt István Komlósi, Nóra Kovács, Willem van de Veen, Anna Kirsch, Heinz Benedikt Fahrner, Marcin Wawrzyniak, Ana Rebane, Barbara Stanic, Oscar Palomares, Beate Rückert, Günter Menz, Mübeccel Akdis, György Losonczy, Cezmi A Akdis
BACKGROUND: Type 3 innate lymphoid cells (ILC3s) are involved in the maintenance of mucosal homeostasis; however, their role in immunoregulation has been unknown. Immature transitional regulatory B (itBreg) cells are innate-like B cells with immunosuppressive properties, and the in vivo mechanisms by which they are induced have not been fully clarified. OBJECTIVE: We aimed to investigate the ILC3-B cell interaction that probably takes place in human tonsils. METHODS: ILC3s were isolated from peripheral blood and palatine tonsils, expanded and cocultured with naïve B cells...
September 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28939127/urinary-melamine-excretion-and-increased-markers-of-renal-tubular-injury-in-patients-with-calcium-urolithiasis-a-cross-sectional-study
#18
Chia-Chu Liu, Tusty-Jiuan Hsieh, Chia-Fang Wu, Yi-Chun Tsai, Shu-Pin Huang, Yung-Chin Lee, Tsung-Yi Huang, Jung-Tsung Shen, Yii-Her Chou, Chun-Nung Huang, Wen-Jeng Wu, Ming-Tsang Wu
Environmental low-dose melamine exposure has been associated with urolithiasis risk in adults, but it is unclear if this exposure can cause early renal damage. This cross-sectional study investigated the association of this exposure and early renal damage in patients with calcium urolithiasis. We recruited patients diagnosed with upper urinary tract calcium urolithiasis from three hospitals in southwestern Taiwan between November 2010 and January 2015. All patients completed a structured questionnaire and provided one-spot urine samples for the measurement of melamine level and markers of early renal injury, including N-acetyl b-d-glucosaminidase (NAG), β2-microglobulin (β2-MG), and microalbumin...
September 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28938748/random-start-ovarian-stimulation-for-fertility-preservation-appears-unlikely-to-delay-initiation-of-neoadjuvant-chemotherapy-for-breast-cancer
#19
Joseph M Letourneau, Nikita Sinha, Kaitlyn Wald, Eve Harris, Molly Quinn, Tal Imbar, Evelyn Mok-Lin, A Jo Chien, Mitchell Rosen
STUDY QUESTION: Is random start ovarian stimulation associated with delays in initiation of neoadjuvant chemotherapy for breast cancer? SUMMARY ANSWER: Among women who complete fertility preservation (FP) consultation, random start ovarian stimulation is unlikely to delay time to initiation of neoadjuvant chemotherapy start. WHAT IS KNOWN ALREADY: Neoadjuvant chemotherapy is now a widely accepted treatment modality for operable breast cancer and random start ovarian stimulation is an increasingly-utilized modality for FP...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938652/correlation-between-apparent-diffusion-coefficient-adc-and-cellularity-is-different-in-several-tumors-a-meta-analysis
#20
Alexey Surov, Hans Jonas Meyer, Andreas Wienke
The purpose of this meta-analysis was to provide clinical evidence regarding relationship between ADC and cellularity in different tumors based on large patient data. Medline library was screened for associations between ADC and cell count in different tumors up to September 2016. Only publications in English were extracted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) was used for the research. Overall, 39 publications with 1530 patients were included into the analysis...
August 29, 2017: Oncotarget
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