Sunny Goon, Chinky Shiu Chen Liu, Uddipta Ghosh Dastidar, Barnali Paul, Suravi Mukherjee, Himadri Sekhar Sarkar, Milie Desai, Rituparna Jana, Sourav Pal, Namala Venkata Sreedevi, Dipyaman Ganguly, Arindam Talukdar
Piezo1, a mechano-activated ion channel, has wide-ranging physiological and therapeutic implications, with the ongoing development of specific agonists unveiling cellular responses to mechanical stimuli. In our study, we systematically analyzed the chemical subunits in Piezo1 protein agonist Yoda1 to comprehend the structure-activity relationship and push forward next-generation agonist development. Preliminary screening assays for Piezo1 agonism were performed using the Piezo1-mCherry-transfected HEK293A cell line, keeping Yoda1 as a positive control...
May 8, 2024: Journal of Medicinal Chemistry