keyword
MENU ▼
Read by QxMD icon Read
search

Stoke

keyword
https://www.readbyqxmd.com/read/28334154/ethical-issues-of-crispr-technology-and-gene-editing-through-the-lens-of-solidarity
#1
John J Mulvihill, Benjamin Capps, Yann Joly, Tamra Lysaght, Hub A E Zwart, Ruth Chadwick
Background: The avalanche of commentaries on CRISPR-Cas9 technology, a bacterial immune system modified to recognize any short DNA sequence, cut it out, and insert a new one, has rekindled hopes for gene therapy and other applications and raised criticisms of engineering genes in future generations. Sources of data: This discussion draws on articles that emphasize ethics, identified partly through PubMed and Google, 2014-2016. Areas of agreement: CRISPR-Cas9 has taken the pace and prospects for genetic discovery and applications to a high level, stoking anticipation for somatic gene engineering to help patients...
February 23, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28328542/an-excited-state-intramolecular-photon-transfer-fluorescence-probe-for-localizable-live-cell-imaging-of-cysteine
#2
Wei Liu, Wen Chen, Si-Jia Liu, Jian-Hui Jiang
Small molecule probes suitable for selective and specific fluorescence imaging of some important but low-concentration intracellular reactive sulfur species such as cysteine (Cys) pose a challenge in chemical biology. We present a readily available, fast-response fluorescence probe CHCQ-Ac, with 2-(5'-chloro-2-hydroxyl-phenyl)-6-chloro-4(3 H)-quinazolinone (CHCQ) as the fluorophore and acrylate group as the functional moiety, that enables high-selectivity and high-sensitivity for detecting Cys in both solution and biological system...
March 22, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28326631/group-treatment-for-substance-abuse-a-stages-of-change-therapy-manual-2nd-edn-mary-velasquez-cathy-crouch-nanette-stokes-stephens-carlo-c-diclemente-new-york-usa-the-guildford-press-2016-isbn-978-1-4625-2340-5-308%C3%A2-pp-paperback-price-75-00-available-to-purchase
#3
https://www.readbyqxmd.com/read/28324708/removal-of-haloacetic-acids-from-swimming-pool-water-by-reverse-osmosis-and-nanofiltration
#4
Linyan Yang, Qianhong She, Man Pun Wan, Rong Wang, Victor W-C Chang, Chuyang Y Tang
Recent studies report high concentrations of haloacetic acids (HAAs), a prevalent class of toxic disinfection by-products, in swimming pool water (SPW). We investigated the removal of 9 HAAs by four commercial reverse osmosis (RO) and nanofiltration (NF) membranes. Under typical SPW conditions (pH 7.5 and 50 mM ionic strength), HAA rejections were >60% for NF270 with molecular weight cut-off (MWCO) equal to 266 Da and equal or higher than 90% for XLE, NF90 and SB50 with MWCOs of 96, 118 and 152 Da, respectively, as a result of the combined effects of size exclusion and charge repulsion...
March 10, 2017: Water Research
https://www.readbyqxmd.com/read/28322944/new-insights-into-non-enzymatic-glycation-of-human-serum-albumin-biopolymer-a-study-to-unveil-its-impaired-structure-and-function
#5
Alok Raghav, Jamal Ahmad, Khursheed Alam, Asad U Khan
Albumin glycation and subsequent formation of advanced glycation end products (AGEs) correlate with diabetes and associated complications. Human Serum Albumin (HSA) was modified with d-glucose for a 40day period under sterile conditions at 37°C. Modified samples along with native HSA (unmodified) were analyzed for impairment in biochemical characteristics ((fructosamine, carbonyl, thiol, lysine, arginine, hydroxymethyl furfural [HMF] content), electrochemical (electrical conductance), simulated gastric fluid assay, simulated intestinal fluid assay, spectroscopic properties (UV, fluorescence), optical (surface contact angle) and fluid dynamics (viscosity and Stokes radius)...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28322219/two-dimensional-turbulence-in-symmetric-binary-fluid-mixtures-coarsening-arrest-by-the-inverse-cascade
#6
Prasad Perlekar, Nairita Pal, Rahul Pandit
We study two-dimensional (2D) binary-fluid turbulence by carrying out an extensive direct numerical simulation (DNS) of the forced, statistically steady turbulence in the coupled Cahn-Hilliard and Navier-Stokes equations. In the absence of any coupling, we choose parameters that lead (a) to spinodal decomposition and domain growth, which is characterized by the spatiotemporal evolution of the Cahn-Hilliard order parameter ϕ, and (b) the formation of an inverse-energy-cascade regime in the energy spectrum E(k), in which energy cascades towards wave numbers k that are smaller than the energy-injection scale kin j in the turbulent fluid...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28319388/visualizing-intramolecular-vibrational-redistribution-in-cyclotrimethylene-trinitramine-rdx-crystal-by-multiplex-coherent-anti-stokes-raman-scattering
#7
Guoyang Yu, Yangyang Zeng, Wencan Guo, Honglin Wu, Gangbei Zhu, Zhaoyang Zheng, Xianxu Zheng, Yunfei Song, Yanqiang Yang
The femtosecond time-resolved multiplex coherent anti-Stokes Raman scattering (CARS) technique has been performed to investigate the intramolecular vibrational redistribution (IVR) through vibrational couplings in RDX molecules. In the multiplex CARS experiment, the supercontinuum (SC) was used as broadband Stokes light to coherently and collectively excite multiple vibrational modes, and quantum beats arising from vibrational couplings among these modes were observed. The IVR of RDX is visualized by a topological graph of these vibrational couplings...
March 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28314626/cerebral-hemodynamic-effects-of-cheyne-stokes-respiration-in-a-patient-with-stroke
#8
R C Nogueira, R B Panerai, M J Teixeira, T G Robinson, E Bor-Seng-Shu
INTRODUCTION: Cheyne-Stokes respiration (CSR) and central sleep apnea (CSA) are common in patients with heart failure and/or stroke. We aim to describe the cerebrovascular effects of CSR during the acute phase of stroke in a heart failure patient. CASE REPORT: A 74-year-old male with previous dilated cardiomyopathy had sudden onset of right hemiparesis and aphasia. A transcranial Doppler was performed with continuous measurement of blood pressure (BP) (Finometer) and end-tidal CO2 (nasal capnography)...
March 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28314048/modeling-electrokinetics-in-ionic-liquids
#9
Chao Wang, Jie Bao, Wenxiao Pan, Xin Sun
Using direct numerical simulations, we provide a thorough study regarding the electrokinetics of ionic liquids. In particular, modified Poisson-Nernst-Planck (MPNP) equations are solved to capture the crowding and overscreening effects characteristic of an ionic liquid. For modeling electrokinetic flows in an ionic liquid, the MPNP equations are coupled with Navier-Stokes equations to study the coupling of ion transport, hydrodynamics, and electrostatic forces. Specifically, we consider the ion transport between two parallel charged surfaces, charging dynamics in a nanopore, capacitance of electric double-layer capacitors, electro-osmotic flow in a nanochannel, electroconvective instability on a plane ion-selective surface, and electroconvective flow on a curved ion-selective surface...
March 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28306248/temperature-sensing-using-thermal-population-of-low-lying-energy-levels-with-sm0-01gd0-99-vo4
#10
Jiajia Cai, Lu Zhao, Fangfang Hu, Xiantao Wei, Yonghu Chen, Min Yin, Chang-Kui Duan
A temperature sensing scheme is proposed that is based on the dramatic temperature dependence of the photoluminescence when Sm(3+) dopants are excited from thermally populated (6)H7/2,9/2 levels, rather than the ground level (6)H5/2, to the (4)G5/2 luminescent level. The scheme has the advantage of eliminating laser heating and background Stokes-type scattering noise. Experimental realization was carried out on a (Sm0.01Gd0.99)VO4 sample by detecting the intensities at 550-580 nm using excitation wavelengths of 601...
March 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28306169/economic-burden-of-relapsed-or-refractory-multiple-myeloma-results-from-an-international-trial
#11
Don Robinson, Robert Z Orlowski, Michael Stokes, Jianming He, Samuel Huse, Abhishek Chitnis, Britte Kranenburg, Annette Lam
OBJECTIVE: The direct cost of relapsed or refractory multiple myeloma (RRMM) is documented; indirect costs are being explored. Healthcare payers seek cost offsets from therapies that improve clinical outcomes but challenge budgets; employers seek lower absenteeism and better productivity. Study goals were to: 1) Identify direct and indirect economic factors of RRMM and, 2) Explore longitudinal relationships between clinical, economic, and health-related quality of life (HRQoL) assessments...
March 17, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28304304/raman-spectrometric-detection-methods-for-early-and-non-invasive-diagnosis-of%C3%A2-alzheimer-s-disease
#12
Chia-Chi Huang, Ciro Isidoro
The continuous increasing rate of patients suffering of Alzheimer's disease (AD) worldwide requires the adoption of novel techniques for non-invasive early diagnosis and monitoring of the disease. Here we review the various Raman spectroscopic techniques, including Fourier Transform-Raman spectroscopy, surface-enhanced Raman scattering spectroscopy, coherent anti-Stokes Raman scattering spectroscopy, and confocal Raman microspectroscopy, that could be used for the diagnosis of AD. These techniques have shown the potential to detect AD biomarkers, such as the amyloid-β peptide and the tau protein, or the neurotransmitters involved in the disease (e...
March 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28304116/diagnostic-accuracy-of-computed-tomography-guided-biopsy-in-pathological-fractures
#13
Christopher M Stokes, Osama Elsewaisy, Grant Pang, John L Slavin, Stephen M Schlicht, Peter F M Choong
BACKGROUND: Obtaining a histological diagnosis is essential for appropriate management of pathological fractures. Computed tomography (CT) is an accurate method of obtaining diagnosis for musculoskeletal tumours. We analysed whether diagnostic accuracy was maintained in the evaluation of pathological fractures. METHODS: A retrospective review of 101 consecutive patients presenting to our tertiary musculoskeletal tumour centre with pathological fracture was performed...
March 17, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28303752/bone-morphogenetic-proteins-and-dickkopf-1-in-ankylosing-spondylitis
#14
H-T Liao, Y-F Lin, C-Y Tsai, T-C Chou
OBJECTIVES: To determine bone morphogenetic proteins (BMPs) and Dickkopf homologue-1 (Dkk-1) levels in ankylosing spondylitis (AS). METHOD: Serum BMPs and Dkk-1 were measured in 72 AS patients and 30 healthy controls. For AS patients, we recorded the demographic data, disease activity, functional index, and global assessment with questionnaires, and image changes with roentgenography. We also measured human leucocyte antigen-B27 and systemic inflammatory reactants...
March 17, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28303488/photophysics-of-dihydroquinazolinone-derivatives-experimental-and-theoretical-studies
#15
Mehboobali Pannipara, Abdullah G Al-Sehemi, Abul Kalam, T N Mohammed Musthafa
Herein, we report the synthesis of two dihydroquinazolinone derivative 2-(2-Hydroxy-naphthalen-1-yl)-2, 3-dihydro-1H-quinazolin-4-one (1) and 2-(3-Methyl-thiophen-2-yl)-2,3-dihydro-1H-quinazolin-4-one (2) by using 2-aminobenzamide, 2-hydroxybenzaldehyde and 3-methyl thiophene-2-carboxaldehyde. The synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR and its spectral, photophysical, intramolecular charge transfer characteristics were studied by absorption and emission spectroscopy. The synthesized compound exhibits significant changes in their photophysical properties depending on the solvent polarity...
March 17, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28301079/survival-impact-of-induction-chemotherapy-in-advanced-head-and-neck-cancer-a-national-cancer-database-analysis
#16
William A Stokes, Arya Amini, Bernard L Jones, Jessica D McDermott, David Raben, Debashis Ghosh, Julie A Goddard, Daniel W Bowles, Sana D Karam
BACKGROUND: Adding induction chemotherapy to concurrent chemotherapy and radiotherapy (RT) has generally not improved the overall survival (OS) in randomized trials of patients with head and neck cancer. This failure may stem from inadequate power or inappropriate patient selection, prompting this National Cancer Data Base analysis. METHODS: 8031 patients with T4 or N2b to N3 disease undergoing RT and chemotherapy were divided into induction chemotherapy and concurrent chemotherapy cohorts...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28300629/insights-into-caco-2-cell-culture-structure-using-coherent-anti-stokes-raman-scattering-cars-microscopy
#17
Jukka Saarinen, Erkan Sözeri, Sara J Fraser-Miller, Leena Peltonen, Hélder A Santos, Antti Isomäki, Clare J Strachan
We have used coherent anti-Stokes Raman scattering (CARS) microscopy as a novel and rapid, label-free and non-destructive imaging method to gain structural insights into live intestinal epithelial cell cultures used for drug permeability testing. Specifically we have imaged live Caco-2 cells in (bio)pharmaceutically relevant conditions grown on membrane inserts. Imaging conditions were optimized, including evaluation of suitable membrane materials and media solutions, as well as tolerable laser powers for non-destructive imaging of the live cells...
March 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28298566/ultrasound-evaluation-of-the-entheses-in-daily-clinical-practice-during-tumor-necrosis-factor-%C3%AE-blocking-therapy-in-patients-with-ankylosing-spondylitis
#18
Fréke Wink, George A Bruyn, Fiona Maas, Ed N Griep, Eveline van der Veer, Hendrika Bootsma, Elisabeth Brouwer, Suzanne Arends, Anneke Spoorenberg
OBJECTIVE: To assess structural and inflammatory ultrasound (US) lesions of entheses in ankylosing spondylitis (AS) patients with active disease and to evaluate inflammatory lesions after 6 months of tumor necrosis factor (TNF-α) blocking therapy, in daily clinical practice. METHODS: Consecutive patients with AS were clinically evaluated and underwent US examination of 9 bilateral entheses before and after 6 months of TNF-α blocking therapy. US examination included the following as inflammatory lesions: bone erosions/cortical irregularities, enthesophytes, calcifications as structural lesions; adjacent bursitis, effusion, increased tendon hypoechogenicity or thickness; and positive power Doppler (PD) signal...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28297972/instabilities-of-a-rotating-helical-rod-in-a-viscous-fluid
#19
Yunyoung Park, Yongsam Kim, William Ko, Sookkyung Lim
Bacteria such as Vibrio alginolyticus swim through a fluid by utilizing the rotational motion of their helical flagellum driven by a rotary motor. The flagellar motor is embedded in the cell body and turns either clockwise (CW) or counterclockwise (CCW), which may lead to straight forward or backward swimming, or reorientation of the cell. In this paper we investigate the dynamics of the helical flagellum by adopting the Kirchhoff rod theory in which the flagellum is described as a space curve associated with orthonormal triads that measure the degree of bending and twisting of the rod...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297968/lattice-boltzmann-simulations-of-microswimmer-tracer-interactions
#20
Joost de Graaf, Joakim Stenhammar
Hydrodynamic interactions in systems composed of self-propelled particles, such as swimming microorganisms and passive tracers, have a significant impact on the tracer dynamics compared to the equivalent "dry" sample. However, such interactions are often difficult to take into account in simulations due to their computational cost. Here, we perform a systematic investigation of swimmer-tracer interaction using an efficient force-counterforce-based lattice-Boltzmann (LB) algorithm [De Graaf et al., J. Chem...
February 2017: Physical Review. E
keyword
keyword
27261
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"