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Andres Carrion, Drucy S Borowitz, Steven D Freedman, Christopher M Siracusa, Jennifer L Goralski, Denis Hadjiladis, Saumini Srinivasan, Dennis C Stokes
The effect of ivacaftor in cystic fibrosis (CF) patients with recurrent pancreatitis is unknown. We conducted a multicenter retrospective study of CF patients taking ivacaftor who had a history of recurrent pancreatitis. During the first three months of therapy, only one of the six patients had an episode of pancreatitis, which was managed on an outpatient basis. Between three and twelve months on ivacaftor therapy, none of the patients had recurrence of pancreatitis or required hospitalization. The use of ivacaftor was associated with a reduced frequency and recurrence rate of pancreatitis in CF patients...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
Robert G Lockie, Matthew R Moreno, Ashley J Orjalo, Adrina Lazar, Tricia M Liu, Alyssa A Stage, Samantha A Birmingham-Babauta, John J Stokes, Dominic V Giuliano, Fabrice G Risso, DeShaun L Davis, Samuel J Callaghan
The study investigated relationships between arm (AL) and leg length (LL) and conventional deadlift (CD) and high-handle hexagonal bar deadlift (HHBD) mechanics. Twenty-three resistance-trained subjects (14 males, 9 females) completed a one-repetition maximum (1RM) CD and HHBD. A linear position transducer was used to measure: lift distance and duration; peak and mean power, velocity, and force; time to peak power and velocity; and work. Right AL and LL were measured, and AL-to-LL ratio (AL:LL) was also calculated...
October 16, 2017: Journal of Strength and Conditioning Research
Robert G Lockie, Matthew R Moreno, Ashley J Orjalo, Alyssa A Stage, Tricia M Liu, Samantha A Birmingham-Babauta, Jillian M Hurley, Ibett A Torne, Megan D Beiley, Fabrice G Risso, DeShaun L Davis, Adrina Lazar, John J Stokes, Dominic V Giuliano
Repeated-sprint ability (RSA) in essential for soccer. Important considerations when assessing RSA is whether there are differences between positions (defenders, midfielders, forwards), and what physiological characteristics may contribute to RSA. This has not been assessed in collegiate male players. Eighteen Division I male field players from one school performed several performance tests. The RSA test involved 7 x 30-m sprints completed on 20-s cycles. Measurements included total time (TT), and performance decrement (percent change in time from the first to last sprint; PD)...
October 16, 2017: Journal of Strength and Conditioning Research
Minakshi Ghate, H K Dahule, N Thejo Kalyani, S J Dhoble
A novel blue luminescent 6-chloro-2-(4-cynophenyl) substituted diphenyl quinoline (Cl-CN DPQ) organic phosphor has been synthesized by the acid-catalyzed Friedlander reaction and then characterized to confirm structural, optical and thermal properties. Structural properties of Cl-CN-DPQ were analyzed by Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) spectroscopy, X-ray diffraction technique (XRD) and scanning electron microscopy (SEM) and energy dispersive analysis of X-ray (EDAX) spectroscopy...
October 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
Przemysław Krawczyk, Beata Jędrzejewska, Piotr Cysewski, Tomasz Janek
In this study, a new oxazolone derivative 4-{N,N-bis[2-phenyl-4-benzylidene-1,3-oxazol-5(4H)-one]amino}benzaldehyde (PB3) was synthesized and investigated as a fluorescent dye. The spectroscopic properties in different solvents were thoroughly studied. The experimental data were supported by quantum-chemical calculations using density functional theory. Measurements and theoretical calculations showed that the PB3 dye is characterized by non-monotonic solvatochromism, a strongly polar charge transfer excited state, a large Stokes' shift, a high fluorescence quantum yield and a high fluorescence lifetime...
October 18, 2017: Organic & Biomolecular Chemistry
Ji Heun Jeong, Jong Hoon An, Hui Yang, Do-Kyung Kim, Nam-Seob Lee, Young-Gil Jeong, Chun Soo Na, Dae Seung Na, Mi-Sook Dong, Seung Yun Han
Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor-binding affinities...
September 2017: Anatomy & Cell Biology
MaryAnn Noonan, Ben Crittenden, Ole Jensen, Mark Stokes
We review a series of studies exploring distractor suppression. It is often assumed that preparatory distractor suppression is controlled via top-down mechanisms of attention akin to those that prepare brain areas for target enhancement. Here, we consider two alternative mechanisms: secondary inhibition and expectation suppression within a predictive coding framework. We draw on behavioural studies, evidence from neuroimaging and some animal studies. We conclude that there is very limited evidence for selective top-down control of preparatory inhibition...
October 14, 2017: Behavioural Brain Research
Xin Wen, Yashuai Han, Jinyu Liu, Jun He, Junmin Wang
A 2.8-dB polarization squeezing of the Stokes operatorS^2for the rubidium D1 line (795 nm) is achieved, with the lowest squeezing band at an audio frequency of 2.6 kHz. It is synthetized by a bright coherent beam and a squeezed vacuum, which are orthogonally polarized and share same frequency. Two methods are applied to support the optical parametric oscillator: an orthogonally-polarized locking beam that precludes residual unwanted interference and quantum noise locking method that locks the squeezing phase...
August 21, 2017: Optics Express
Qin Liu, Caixun Bai, Jie Liu, Jiale He, Jianxin Li
A time-division Fourier transform imaging spectropolarimeter (FTISP) for acquiring spatial, spectral, and polarized information is presented. The FTISP employs two ferroelectric liquid crystals (FLCs) and a Wollaston interferometer. The fast axes of the FLCs are controlled to switch quickly without mechanical movement, enabling the polarization state analyzer (PSA) to modulate the full set of Stokes parameters rapidly. The interferometer combines a Wollaston prism with a retroreflector, enabling high interference modulation and facilitating optical alignment...
August 21, 2017: Optics Express
Gangi Reddy Salla, Vijay Kumar, Yoko Miyamoto, R P Singh
Polarization speckle is a fine granular light pattern having spatially varying random polarization profile. We generate these speckle patterns by using the scattering of Poincaré beams, a special class of vector vortex beams, through a ground glass plate. Here, the Poincaré beams are generated using a polarization sensitive spatial light modulator displaying an on-axis hologram corresponding to an optical vortex phase profile. The different inhomogeneities of the rough surface experience different polarizations, which control the ability for scattered waves to interfere at the detection plane and causes a spatially varying polarization profile...
August 21, 2017: Optics Express
Congwen Zha, Wanjing Peng, Xiaojun Wang, Yanshan Wang, Tenglong Li, Yi Ma, Kai Zhang, Yujun Feng, Jue Peng, Yinhong Sun
The self-pulsing phenomenon in kilowatt level narrow-linewidth fiber amplifiers with white noise source (WNS) phase-modulation is observed experimentally. It possesses the obvious threshold of the pump power and prevents the narrow-linewidth fiber lasers from further power scaling. The experimental study shows that known explanations are not applicable here and indicates that occurrence of self-pulsing is closely related to Stimulated Brillouin Scattering (SBS) process. The theoretical discussion reveals that the spikes in the modulated spectrum are the critical factor that SBS threshold is lower than the theoretical estimation...
August 21, 2017: Optics Express
Z L Liu, Y X Liu, Y Tang, N Zhang, F P Wu, B Zhang
A double-tapered optical fiber tweezers (DOFTs) was fabricated by a chemical etching called interfacial layer etching. In this method, the second taper angle (STA) of DOFTs can be controlled easily by the interfacial layer etching time. Application of the DOFTs to the optical trapping of the yeast cells was presented. Effects of the STA on the axile trapping efficiency and the trapping position were investigated experimentally and theoretically. The experimental results are good agreement with the theoretical ones...
September 18, 2017: Optics Express
Kevin J Mitchell, Neal Radwell, Sonja Franke-Arnold, Miles J Padgett, David B Phillips
Spatial structuring of the intensity, phase and polarisation of light is useful in a wide variety of modern applications, from microscopy to optical communications. This shaping is most commonly achieved using liquid crystal spatial light modulators (LC-SLMs). However, the inherent chromatic dispersion of LC-SLMs when used as diffractive elements presents a challenge to the extension of such techniques from monochromatic to broadband light. In this work we demonstrate a method of generating broadband vector beams with dynamically tunable intensity, phase and polarisation over a bandwidth of 100 nm...
October 16, 2017: Optics Express
A W Al-Alimi, N A Cholan, M H Yaacob, A F Abas, M T Alresheedi, M A Mahdi
A wide bandwidth and flat multiwavelength Brillouin-erbium fiber laser is demonstrated experimentally. In the proposed laser setup, the combination of a Brillouin mirror with feedback and a ring cavity with four-wave mixing assistance is realized. The efficiency of Brillouin Stokes lines generation is enhanced by the feedback-based Brillouin mirror structure. The effect of four-wave mixing in highly nonlinear fiber increases the generation of Brillouin Stokes lines in a wider bandwidth. The laser lines over 16 nm bandwidth (i...
August 7, 2017: Optics Express
Mo Chen, Chenyu Wang, Jianfei Wang, Hong Luo, Zhou Meng
We demonstrate 53-dB phase noise reduction in a compact Brillouin/erbium fiber laser (BEFL), which uses 4-m erbium-doped-fiber (EDF) providing both the Brillouin gain and linear gain. A 360-kHz-linewidth laser diode is used as the Brillouin pump (BP) and excites the Brillouin Stokes light. The linewidth of the BEFL is estimated 1.8-Hz based on the correlation between the linewidth and phase noise. Experimental result demonstrates 6-Hz linewidth by beating the emission of two compact BEFLs. This fiber laser provides a simple and effective method to reduce laser phase noise and realize ultra-narrow-linewidth light...
August 7, 2017: Optics Express
Alla Yankouskaya, Glyn Humphreys, Moritz Stolte, Mark Stokes, Zargol Moradi, Jie Sui
Although theoretical discourse and experimental studies on the self and reward biases have a long tradition, currently we have only a limited understanding of how the biases are represented in the brain and, more importantly, how they relate to each other. We used multi-voxel pattern analysis to test for common representations of self and reward in perceptual matching in healthy human subjects. Voxels across an anterior-posterior axis in ventromedial prefrontal cortex (vmPFC) distinguished (i) self-others and (ii) high-low reward, but cross generalization between these dimensions decreased from anterior to posterior vmPFC...
October 10, 2017: Social Cognitive and Affective Neuroscience
Marc E Rothenberg, Hirohisa Saito, R Stokes Peebles
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH2 lymphocytes; eicosanoid regulation of inflammation; extracellular vesicles in allergic responses; IL-33; microbiome properties, especially as they relate to mucosal barrier function; and a series of findings concerning the allergic inflammatory cells eosinophils, basophils, and mast cells. During the last year, mechanistic advances occurred in understanding type 2 innate lymphoid cells, particularly related to their response to ozone, involvement with experimental food allergy responses, and regulation by IL-33...
October 13, 2017: Journal of Allergy and Clinical Immunology
Julia P Dark, Arnold D Kim
We establish a quantitative theory of circular polarization memory, which is the unexpected persistence of the incident circular polarization state in a strongly scattering medium. Using an asymptotic analysis of the three-dimensional vector radiative transfer equation (VRTE) in the limit of strong scattering, we find that circular polarization memory must occur in a boundary layer near the portion of the boundary on which polarized light is incident. The boundary layer solution satisfies a one-dimensional conservative scattering VRTE...
September 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Noé Ortega-Quijano, Julien Fade, Muriel Roche, François Parnet, Mehdi Alouini
For J. Opt. Soc. Am. A33, 434 (2016)JOAOD60740-323210.1364/JOSAA.33.000434, a corrected version of Eq. (9) is provided owing to typographical errors in the original article. The original full article text and calculations are unchanged. Another typo is corrected in Eq. (A5) of Appendix A.
August 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Colin J R Sheppard, Marco Castello, Giorgio Tortarolo, Giuseppe Vicidomini, Alberto Diaspro
The effect of combining the image scanning microscopy (ISM) technique with two-photon fluorescence microscopy is analyzed. The effective spatial frequency cutoff can be doubled, as compared with conventional two-photon fluorescence microscopy, and the magnitude of the optical transfer function near the cutoff of conventional two-photon microscopy is increased by orders of magnitude. For the two-photon case, it is found that the optimum pixel reassignment factor in ISM is not equal to one half, as is often assumed in single-photon fluoresence image scanning microscopy, because the excitation and detection point spread functions are different...
August 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
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