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Daniel Jaeger, Christian Pilger, Henning Hachmeister, Elina Oberländer, Robin Wördenweber, Julian Wichmann, Jan H Mussgnug, Thomas Huser, Olaf Kruse
Oleaginous photosynthetic microalgae hold great promise as non-food feedstocks for the sustainable production of bio-commodities. The algal lipid quality can be analysed by Raman micro-spectroscopy, and the lipid content can be imaged in vivo in a label-free and non-destructive manner by coherent anti-Stokes Raman scattering (CARS) microscopy. In this study, both techniques were applied to the oleaginous microalga Monoraphidium neglectum, a biotechnologically promising microalga resistant to commonly applied lipid staining techniques...
October 21, 2016: Scientific Reports
Nikolaos Tsamandouras, Tomasz Kostrzewski, Cynthia L Stokes, Linda G Griffith, David J Hughes, Murat Cirit
In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from 5 different donors cultured in a perfused 3D human liver microphysiological system and then show how the resulting data can be integrated with a modeling and simulation framework to accomplish in vitro-in vivo translation. For each donor, metabolic depletion profiles of 6 compounds (phenacetin, diclofenac, lidocaine, ibuprofen, propranolol and prednisolone) were measured, along with metabolite formation, mRNA levels of 90 metabolism-related genes, and markers of functional viability (LDH release, albumin and urea production)...
October 19, 2016: Journal of Pharmacology and Experimental Therapeutics
Rajiv Singh, Saurabh Sinha, Alan Bill, Lynne Turner-Stokes
OBJECTIVE: To identify the needs for specialised rehabilitation provision in a cohort of neurosurgical patients; to determine if these were met, and to estimate the potential cost implications and cost-benefits of meeting any unmet rehabilitation needs. METHODS: A prospective study of in-patient admissions to a regional neurosurgical ward. Assessment of needs for specialised rehabilitation (Category A or B needs) was made with the Patient Categorisation Tool. The number of patients who were referred and admitted for specialised rehabilitation was calculated...
October 19, 2016: British Journal of Neurosurgery
Alexandra Louise Webb, Elizabeth O'Sullivan, Maria Stokes, Sarah Mottram
The serratus anterior is portrayed as a homogeneous muscle in textbooks and during functional activities and rehabilitation exercises. It is unclear whether the serratus anterior is composed of subdivisions with distinctive morphology and functions. The purpose of this study was to determine whether the serratus anterior could be subdivided into different structural parts on the basis of its segmental architectural parameters. Eight formalin-embalmed serratus anterior muscles were dissected and the attachments of each fascicle documented...
October 18, 2016: Anatomical Science International
Anna L Calkins, Jennifer Yin, Jacenda L Rangel, Madeleine R Landry, Amelia A Fuller, Grace Y Stokes
The first report of a water-soluble peptoid adsorbed to silica monitored by second harmonic generation (SHG) at the liquid/solid interface is presented here. The molecular insights gained from these studies will inform the design and preparation of novel peptoid coatings. Simple 6- and 15-residue peptoids were dissolved in phosphate buffered saline and adsorbed to bare silica surfaces. Equilibrium binding constants and relative surface concentrations of adsorbed peptoids were determined from fits to the Langmuir model...
October 18, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Yohei Okada, Masae Sugai, Kazuhiro Chiba
Fluorophores with emission wavelengths that shift depending on their hydrogen-bonding microenvironment in water would be fascinating tools for the study of biological events. Herein, we describe the design and synthesis of a series of water-soluble solvatochromic fluorophores, 2,5-bis(oligoethylene glycol)oxybenzaldehydes (8-11) and 2,5-bis(oligoethylene glycol)oxy-1,4-dibenzaldehydes (14-17), based on a push-pull strategy. Unlike typical examples in this class of fluorophores, the fluorescence properties of these compounds are independent of solvent polarity and become fluorescent upon intermolecular hydrogen-bonding, exhibiting high quantum yields (up to φ = 0...
October 18, 2016: Journal of Organic Chemistry
Atanu Acharya, Alexey M Bogdanov, Bella L Grigorenko, Ksenia B Bravaya, Alexander V Nemukhin, Konstantin A Lukyanov, Anna I Krylov
Photoinduced reactions play an important role in the photocycle of fluorescent proteins from the green fluorescent protein (GFP) family. Among such processes are photoisomerization, photooxidation/photoreduction, breaking and making of covalent bonds, and excited-state proton transfer (ESPT). Many of these transformations are initiated by electron transfer (ET). The quantum yields of these processes vary significantly, from nearly 1 for ESPT to 10(-4)-10(-6) for ET. Importantly, even when quantum yields are relatively small, at the conditions of repeated illumination the overall effect is significant...
October 18, 2016: Chemical Reviews
Boran Lee, Byung Gyu Park, Wansang Cho, Ho Yong Lee, András Olasz, Chun-Hsing Chen, Seung Bum Park, Dongwhan Lee
A series of air-stable boron complexes 1-5 were prepared by using N-aryl iminopyrrolide ligands. Designed as minimalist structural mimics of the privileged BODIPY motif, these new BOIMPY (BOron complexes of IMinoPYrrolide ligands) fluorophores feature low molecular symmetry that promotes emission from CT-type excited states with large Stokes shifts and little self-quenching. Through comparative studies on the homologous set of compounds 1-4, we have confirmed that a delicate interplay between conformational twisting and donor-acceptor interaction dictates the mechanism of de-excitation, which responds sensitively to solvent polarity as well as protonation states...
October 18, 2016: Chemistry: a European Journal
Trefor Morgan
Central Systolic Blood Pressure is lower than brachial artery blood Pressure due to reflected waves and greater augmentation at the periphery. The relationship is not consistent during life and alters with aging of the blood vessels. Increasing stiffness means that a greater component of the reflected waves returns to the central aorta during systolic contraction causing more amplification and a higher systolic blood pressure. Diastolic blood pressure on the other hand is always higher in the aorta than at the periphery allowing blood flow...
September 2016: Journal of Hypertension
Michael Weber
: Age is the most powerful cardiovascular risk factor. Based on a meta-analysis of a million control patients in hypertension trials, the Clinical Trialists Collaboration has estimated that doubling of major cardiac and stroke events occurs with age increments of < 10 years (1). Data from the ACCOMPLISH trial, which will be presented at this ISH meeting for the first time, show that patients aged > 70 (mean: 75.2), compared with those < 70 (mean: 63.7), had a 2.82-fold greater event rate for cardiovascular death and a 2...
September 2016: Journal of Hypertension
Wen Wang, Liyuan Ma, Hui Sui, Lisheng Liu
OBJECTIVE: Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-center randomized controlled clinical trial. The objective is to evaluate the collective effects of antihypertensive therapy, lipid lowering treatment and lifestyle modification in patients with hypertension. This paper merely present blood pressure lowering effect of intensive lifestyle intervention compared with standard lifestyle intervention. CLINICAL TRIAL REGISTRATION: Clinical Trials...
September 2016: Journal of Hypertension
Alisha V DSouza, Kayla Marra, Jason R Gunn, Kimberley S Samkoe, Brian W Pogue
No abstract text is available yet for this article.
October 1, 2016: Journal of Biomedical Optics
Ashley M Stokes, Charles P Hart, C Chad Quarles
High-grade gliomas are often characterized by hypoxia, which is associated with both poor long-term prognosis and therapy resistance. The adverse role hypoxia plays in treatment resistance and disease progression has led to the development of hypoxia imaging methods and hypoxia-targeted treatments. Here, we determined the tumor hypoxia and vascular perfusion characteristics of 2 rat orthotopic glioma models using 18-fluoromisonidozole positron emission tomography. In addition, we determined tumor response to the hypoxia-activated prodrug evofosfamide (TH-302) in these rat glioma models...
September 2016: Tomography: a Journal for Imaging Research
Lei Zhang, Zhisong Huang, Dongdong Dai, Yansheng Xiao, Kecheng Lei, Shaoying Tan, Jiagao Cheng, Yufang Xu, Jianwen Liu, Xuhong Qian
By structure transformation of benzo[k,l]thioxanthene-naphthalimide derivatives (ND-S), a novel series of nonplanar thio-heterocyclic bisnaphthalimide derivatives are designed and synthesized. They display high molar absorptivity and large Stokes shifts. They are also heavy-atom-free photosensitizers with high singlet oxygen quantum yields of 0.75 and 0.82. Thus, these new structures based on the naphthalimide skeleton have great potential for singlet oxygen applications.
October 18, 2016: Organic Letters
Irene Estévez, Victor Sopo, Angel Lizana, Alex Turpin, Juan Campos
We propose a new complete snapshot Stokes polarimeter based on a single biaxial crystal. It presents different strengths (snapshot, complete polarimetric measurements, large data redundancy, and high sensitivity) in a simple and compact optical arrangement. The polarimeter is experimentally implemented and analyzed in terms of accuracy and repeatability.
October 1, 2016: Optics Letters
Shanmugam Karthik, Joseph Ajantha, C M Nagaraja, Shanmugam Easwaramoorthi, Thirumanavelan Gandhi
The synthesis of π-extended 10-aryl-pyrenoimidazoles having different substituents was realised via Ru(ii)-catalyzed oxidative annulation of 10-aryl-pyrenoimidazole with diphenylacetylene. The single crystal X-ray structure of trifluoromethyl and carboxylate substituted annulated-10-aryl-pyrenoimidazoles confirms the near coplanarity of the pyrene and imidazole moieties and the presence of twisted conformation resulting in intermolecular C-Hπ interactions. The lowest energy absorption maximum becomes red-shifted characteristic to the nature of the substituent owing to the extended π-conjugation, and specifically the nitro substituent shows intense absorption in the visible region with the maximum at 440 nm...
October 17, 2016: Organic & Biomolecular Chemistry
Leandro P Ravaro, Tiago R Almeida, Rodrigo Q Albuquerque, Andrea S S de Camargo
The polynuclear complex Cu4I4py4 has been largely studied in solution and in the powder form due to its interesting luminescent properties, which are largely dependent on temperature and pressure. In this work, we present the synthesis of the complex and its wet impregnation in a mesoporous silica host obtained by sol-gel methodology. For optimized loadings, the well-dispersed guest molecules exhibit strong interaction with molecular oxygen, resulting in a significant quenching of the luminescence. The process is highly reversible with a Stern-Volmer constant of Ksv = 33...
October 17, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Santosh Kumar, Daizy Bharti, Pablo Quintela-Alonso, Mann Kyoon Shin, Antonietta La Terza
The morphology and morphogenesis of two stylonychid ciliates, Stylonychia ammermanniGupta et al., 2001 and Tetmemena bifaria (Stokes, 1887) Berger, 2001, isolated from soil samples of Lombardia region, Northern Italy, and water samples from Cheonggancheon stream, South Korea, were investigated. The Italian population of S. ammermanni was found to be very similar in morphology to the Indian type population and the junior synonym S. harbinensisShi and Ammermann, 2004 since most of the morphometric data overlapped...
September 23, 2016: European Journal of Protistology
Lauren M Nentwich
Acute ischemic stroke is a challenging and time-sensitive diagnosis. Diagnosis begins with rapid detection of acute stroke symptoms by the patient, their family or caregivers, or bystanders. If acute stroke is suspected, EMS providers should be called for rapid assessment. EMS providers will utilize prehospital stroke tools to diagnose and determine potential stroke severity. Once at the hospital, the stroke team works rapidly to solidify the patient history, perform a focused neurologic examination and obtain necessary laboratory tests and brain imaging to accurately diagnose acute ischemic stroke and properly treat the patient...
November 2016: Emergency Medicine Clinics of North America
Eric Lauga, Sébastien Michelin
Active particles disturb the fluid around them as force dipoles, or stresslets, which govern their collective dynamics. Unlike swimming speeds, the stresslets of active particles are rarely determined due to the lack of a suitable theoretical framework for arbitrary geometry. We propose a general method, based on the reciprocal theorem of Stokes flows, to compute stresslets as integrals of the velocities on the particle's surface, which we illustrate for spheroidal chemically active particles. Our method will allow tuning the stresslet of artificial swimmers and tailoring their collective motion in complex environments...
September 30, 2016: Physical Review Letters
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