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https://www.readbyqxmd.com/read/28814064/electrical-properties-assessed-by-bioelectrical-impedance-spectroscopy-as-biomarkers-of-age-related-loss-of-skeletal-muscle-quantity-and-quality
#1
Yosuke Yamada, Bjoern Buehring, Diane Krueger, Rozalyn M Anderson, Dale A Schoeller, Neil Binkley
Skeletal muscle, in addition to being comprised of a heterogeneous muscle fiber population, also includes extracellular components that do not contribute to positive tensional force production. Here we test segmental bioelectrical impedance spectroscopy (S-BIS) to assess muscle intracellular mass and composition. S-BIS can evaluate electrical properties that may be related to muscle force production. Muscle fiber membranes separate the intracellular components from the extracellular environment and consist of lipid bilayers which act as an electrical capacitor...
September 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28813675/cd44-interacts-with-hif-2%C3%AE-to-modulate-the-hypoxic-phenotype-of-perinecrotic-and-perivascular-glioma-cells
#2
Elinn Johansson, Elisa S Grassi, Vasiliki Pantazopoulou, Bei Tong, David Lindgren, Tracy J Berg, Elin J Pietras, Håkan Axelson, Alexander Pietras
Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. Still, little is known about differential HIF regulation in stem versus bulk glioma cells. We show that the intracellular domain of stem cell marker CD44 (CD44ICD) is released at hypoxia, binds HIF-2α (but not HIF-1α), enhances HIF target gene activation, and is required for hypoxia-induced stemness in glioma. In a glioma mouse model, CD44 was restricted to hypoxic and perivascular tumor regions, and in human glioma, a hypoxia signature correlated with CD44...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28813609/co-assembly-kinetics-of-graphene-oxide-and-block-copolymers-at-the-water-oil-interface
#3
Dayong Chen, Zhiwei Sun, Thomas P Russell, Lihua Jin
The co-assembly kinetics of graphene oxide (GO) nanosheets and diblock copolymers at the water/toluene interface is probed by tracking the dynamic interfacial tension using pendant drop tensiometry. The diblock copolymer significantly enhances the surfactancy of the GO nanosheets at the interface. It is found that diblock copolymers rapidly adsorb to the water/toluene interface and enhance the adsorption affinity of GO nanosheets to the interface. The continuous adsorption of GO at the interface leads to a random loose packing state, at which the adsorbed GO and diblock copolymers start to form an elastic film...
August 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28813590/understanding-the-elementary-steps-in-dna-tile-based-self-assembly
#4
Shuoxing Jiang, Fan Hong, Huiyu Hu, Hao Yan, Yan Liu
Although many models have been developed to guide the design and implementation of DNA tile-based self-assembly systems with increasing complexity, the fundamental assumptions of the models have not been thoroughly tested. To expand the quantitative understanding of DNA tile-based self-assembly and to test the fundamental assumptions of self-assembly models, we investigated DNA tile attachment to preformed "multi-tile" arrays in real time, and obtained the thermodynamic and kinetic parameters of single tile attachment in various sticky end association scenarios...
August 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28813190/under-pressure-the-tension-between-access-and-abuse-of-opioids-in-cancer-pain-management
#5
Judith A Paice
No abstract text is available yet for this article.
August 16, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28813174/depressive-symptoms-and-drinking-outcomes-the-mediating-role-of-drinking-motives-and-protective-behavioral-strategies-among-college-students
#6
Margo C Villarosa, Mary Anne Messer, Michael B Madson, Virgil Zeigler-Hill
BACKGROUND: College students with depressive symptoms tend to engage in more hazardous drinking and experience more alcohol-related consequences to cope with their symptoms. Given the perceived tension reducing effects of alcohol among these students, it is important to explore how protective factors, such as protective behavioral strategies, account for the relationships among depressive symptoms, drinking motives, and alcohol-related outcomes. OBJECTIVE: To examine the mediating role of drinking motives and protective behavioral strategies on the associations that depressive symptoms have with typical weekly alcohol consumption, hazardous drinking, and alcohol-related negative consequences in a sample of college student drinkers...
August 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28813110/trait-vs-state-anxiety-in-different-threatening-situations
#7
Pollyana Caldeira Leal, Tiago Costa Goes, Luiz Carlos Ferreira da Silva, Flavia Teixeira-Silva
Objective: Anxiety as a uni- or multidimensional construct has been under discussion. The unidimensional approach assumes that there is a general trait anxiety, which predisposes the individuals to increases in state anxiety in various threatening situations. In this case, there should be a correlation between state and trait anxiety in any situation of threat. Therefore, the aim of this study was to investigate the correlation between trait and state anxiety in participants exposed to two different anxiogenic situations: interpersonal threat (Video-Monitored Stroop Test - VMST) and physical threat (third molar extraction - TME)...
August 14, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28812821/-re-making-the-procrustean-bed-standardization-and-customization-as-competing-logics-in-healthcare
#8
EDITORIAL
Russell Mannion, Mark Exworthy
Recent years have witnessed a parallel and seemingly contradictory trend towards both the standardization and the customization of healthcare and medical treatment. Here, we explore what is meant by 'standardization' and 'customization' in healthcare settings and explore the implications of these changes for healthcare delivery. We frame the paradox of these divergent and opposing factors in terms of institutional logics - the socially constructed rules, practices and beliefs which perpetuate institutional behaviour...
March 28, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812091/influence-of-surface-tension-in-the-surfactant-driven-fracture-of-closely-packed-particulate-monolayers
#9
Christian Peco, Wei Chen, Yingjie Liu, M M Bandi, John E Dolbow, Eliot Fried
A phase-field model is used to capture the surfactant-driven formation of fracture patterns in particulate monolayers. The model is intended for the regime of closely-packed systems in which the mechanical response of the monolayer can be approximated as that of a linearly elastic solid. The model approximates the loss in tensile strength of the monolayer with increasing surfactant concentration through the evolution of a damage field. Initial-boundary value problems are constructed and spatially discretized with finite element approximations to the displacement and surfactant damage fields...
August 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/28812014/surgical-approach-may-influence-survival-of-large-diameter-head-metal-on-metal-total-hip-arthroplasty-a-6-to-10-year-follow-up-study
#10
Chih-Chien Hu, Tsan-Wen Huang, Shih-Jie Lin, Po-Chun Lin, Feng-Chih Kuo, Kuo-Ti Peng, Kuo-Chin Huang, Hsin-Nung Shih, Mel S Lee
Large-diameter head (LDH) metal-on-metal (MoM) total hip arthroplasty (THA) has lost popularity because of metal allergy or ALTRs (adverse local tissue reactions) in the past decade. Whether the surgical approach may influence the survival of LDH-MoM-THA has not been reported. From 2006 to 2009, we performed 96 LDH-MoM-THAs on 80 patients using an in situ head-neck assembly technique through a modified Watson-Jones approach. With a mean follow-up of 8.4 years (range, 6.3-10.1 years), the implant survival rate was 100%...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811798/an-experience-with-mesh-versus-darn-repair-in-inguinal-hernias
#11
Gulshan Ali Memon, Syed Kashif Ali Shah, Habib-Ur-Rehman
BACKGROUND & OBJECTIVE: The inguinal hernia accounts for 50 percent in old age males. A Lichtenstein type of operation has now become the method of choice in most developed countries but in the developing world traditional simple suture repair is still in common practice in resource limited hospitals due to the scarcity and expensive nature of the commercial prosthetic mesh. Our objective was to compare the rates of complications in Lichtenstein repair to tension free Darn repair. METHODS: Ninety two male patients from 20-60 years of age reported for direct or indirect inguinal hernia with open Mesh/Lichtenstein or darn repair in emergency or electively from January 2014 to December 2015 were enrolled in this prospective randomized control trial (RCT)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811566/injectable-phosphorescence-based-oxygen-biosensors-identify-post-ischemic-reactive-hyperoxia
#12
Jennifer S Chien, Mahmoud Mohammed, Hysem Eldik, Mohamed M Ibrahim, Jeremy Martinez, Scott P Nichols, Natalie Wisniewski, Bruce Klitzman
Novel injectable biosensors were used to measure interstitial oxygenation before, during, and after transient ischemia. It is well known that reactive hyperemia occurs following a period of ischemia. However, increased blood flow does not necessarily mean increased oxygen tension in the tissue. Therefore, the purpose of this study was to test the hypothesis that tissue reactive hyperoxia occurs following release of hind-limb tourniquet occlusions. Rats were injected with bilateral hind-limb biosensors and were simultaneously subjected to a unilateral femoral vessel ligation...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811304/selectin-catch-bonds-mechanotransduce-integrin-activation-and-neutrophil-arrest-on-inflamed-endothelium-under-shear-flow
#13
Vasilios A Morikis, Shannon Chase, Ted Wun, Elliot L Chaikof, John L Magnani, Scott I Simon
E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolling under shear stress. Its ligands are glycosylated with the tetrasaccharide sialyl Lewis(x) (sLe(x)), which contributes to bond affinity and specificity. E-selectin mediated rolling transmits signals into neutrophils that triggers activation of high-affinity β2-integrins necessary for transition to shear resistant adhesion and transendothelial migration...
August 15, 2017: Blood
https://www.readbyqxmd.com/read/28810996/rhabdomyolysis-after-crawling-military-training
#14
Danit Atias-Varon, Haggai Sherman, Ran Yanovich, Yuval Heled
INTRODUCTION: Rhabdomyolysis is a syndrome characterized by muscle necrosis followed by release of intracellular muscle contents into the circulation. Exertional rhabdomyolysis (ER) occurs in response to nonfamiliar and/or excessive, prolonged, or repetitive exercises, with eccentric characteristics. In military populations, due to the type of intense, all out physical loads, ER is a significant threat, particularly when training under heat stress. However, many other etiologies exist, and clinical presentations vary greatly...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810921/the-role-of-whole-body-computed-tomography-in-the-diagnosis-of-thoracic-injuries-in-severely-injured-patients-a-retrospective-multi-centre-study-based-on-the-trauma-registry-of-the-german-trauma-society-traumaregister-dgu-%C3%A2
#15
Patricia Lang, Martin Kulla, Fabian Kerwagen, Rolf Lefering, Benedikt Friemert, Hans-Georg Palm
BACKGROUND: Thoracic injuries are a leading cause of death in polytrauma patients. Early diagnosis and treatment are of paramount importance. Whole-body computed tomography (WBCT) has largely replaced traditional imaging techniques such as conventional radiographs and focused computed tomography (CT) as diagnostic tools in severely injured patients. It is still unclear whether WBCT has led to higher rates of diagnosis of thoracic injuries and thus to a change in outcomes. METHODS: In a retrospective study based on the trauma registry of the German Trauma Society (TraumaRegister DGU(®)), we analysed data from 16,545 patients who underwent treatment in 59 hospitals between 2002 and 2012 (ISS ≥ 9)...
August 15, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28810784/molecular-simulation-of-homogeneous-crystal-nucleation-of-ab2-solid-phase-from-a-binary-hard-sphere-mixture
#16
Praveen Kumar Bommineni, Sudeep N Punnathanam
Co-crystal formation from fluid-mixtures is quite common in a large number of systems. The simplest systems that show co-crystal (also called substitutionally ordered solids) formation are binary hard sphere mixtures. In this work, we study the nucleation of AB2 type solid compounds using Monte Carlo molecular simulations in binary hard sphere mixtures with the size ratio of 0.55. The conditions chosen for the study lie in the region where nucleation of an AB2 type solid competes with that of a pure A solid with a face-centered-cubic structure...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810752/rupturing-the-hemi-fission-intermediate-in-membrane-fission-under-tension-reaction-coordinates-kinetic-pathways-and-free-energy-barriers
#17
Guojie Zhang, Marcus Müller
Membrane fission is a fundamental process in cells, involved inter alia in endocytosis, intracellular trafficking, and virus infection. Its underlying molecular mechanism, however, is only incompletely understood. Recently, experiments and computer simulation studies have revealed that dynamin-mediated membrane fission is a two-step process that proceeds via a metastable hemi-fission intermediate (or wormlike micelle) formed by dynamin's constriction. Importantly, this hemi-fission intermediate is remarkably metastable, i...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810623/evaluation-of-heat-shock-protein-hsp-72-expression-in-retinal-ganglion-cells-of-rats-with-glaucoma
#18
Guo-Hua Wang, Yi-Qiao Xing
The present study was planned to observe the expression of heat shock protein 72 (HSP72) in retina of rats in a glaucoma model. A total of 50 Wistar rats were randomly divided into the high intraocular tension group (glaucoma model) and the sham control (sham operation) group. Glaucoma rat models were created by application of electrocoagulation on at least three groups of veins, reduction of venous return of aqueous humor and by enhancement of intraocular tension at the same time; 1, 2, 3, 4 and 8 weeks after operation, the intraocular tension of rats was observed respectively, and the expression/distribution of HSP72 in retina was assessed by immunohistochemical detection...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810472/the-rapid-expansion-of-mainstream-health-psychology-in-france-historical-foundations
#19
Marie Santiago-Delefosse, Maria Del Rio Carral
This article traces the historical evolution of ongoing theoretical debates in psychology in France from the 1940s until today. Its aim is to show how the conjunction of certain conditions was determinant for a rapid expansion of American-derived mainstream health psychology during the 1980s. The authors describe the French context in the post-World War II period that made possible the introduction of psychology courses at the university, which included the tensions between two epistemological orientations: experimental psychology and clinical psychology, the latter partly inspired by Politzer's concrete psychology...
June 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810470/representations-and-experiences-of-well-being-among-diabetic-adolescents-relational-normative-and-identity-tensions-in-diabetes-self-management
#20
David Fonte, Sébastien Colson, José Côté, Rachel Reynaud, Marie-Claude Lagouanelle-Simeoni, Thémis Apostolidis
We explore representations of well-being in adolescents with Type 1 diabetes in order to better understand their expectations and needs in therapeutic patient education. In total, 28 interviews were performed and then submitted to thematic content analysis and lexicometric analysis. Results show the intervention of psychosocial processes in the relationship that adolescents maintain with well-being and self-management. More specifically, we observed that well-being is impacted by areas of tension between the expectations of adolescents and the therapeutic objectives expressed by health professionals...
June 1, 2017: Journal of Health Psychology
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