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Gabriel Olaiya Omotoso, Ismail Temitayo Gbadamosi, Olayemi Joseph Olajide, Shakirat Opeyemi Dada-Habeeb, Tolulope Timothy Arogundade, Emmanuel Olusola Yawson
Nicotine is a neuro-stimulant that has been implicated in the pathophysiology of many brain diseases. The need to prevent or alleviate the resulting dysfunction is therefore paramount, which has also given way to the use of medicinal plants in the management of brain conditions. This study was designed to determine the histomorphological and neurobehavioural changes in the cerebellum of Wistar rats following nicotine insult and how such injuries respond to Moringa intervention. Twenty-four adult male Wistar rats were divided into 4 groups...
January 4, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Alain Oliveira Dos Santos, Danielle Rocha do Val, Felipe Dantas da Silveira, Francisco Isaac Fernandes Gomes, Hermany Capistrano Freitas, Ellen Lima de Assis, Diana Kelly Castro de Almeida, Igor Iuco Castro da Silva, Francisco Geraldo Barbosa, Jair Mafezoli, Marcos Reinaldo da Silva, Gerly Anne de Castro Brito, Juliana Trindade Clemente-Napimoga, Vicente de Paulo Teixeira de Paulo Teixera Pinto, Gerardo Cristino Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves
Inflammation is a key component of many clinical conditions that affect the temporomandibular joint (TMJ) and Moringa oleifera Lam. has been used to treat inflammatory diseases. Here, we evaluated the toxicological effects on mice of a naturally-occurring isothiocyanate from M. oleifera and its seven analogue molecules. Further, the anti-nociceptive and anti-inflammatory effects on a rat model of TMJ inflammatory hypernociception were assessed. The systemic toxicological profile was determined in mice over a 14-day period: MC-1 1 μg/kg; MC-D1 1 μg/kg, MC-D3 100 μg/kg, MC-D6 1 μg/kg, MC-D7 1 μg/kg, MC-D8 1 μg/kg, MC-D9 10 μg/kg, and MC-H 1 μg/kg...
December 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Oluwadara Oluwaseun Alegbeleye
Moringa oleifera is an important tropical food plant that seems to have great nutritional, therapeutic, industrial, agricultural, and socioeconomic values. Dietary consumption of its parts and preparations is encouraged by several organizations, health food enthusiasts, and other specialists as a strategy of personal health preservation and self-medication in the treatment of various diseases. Studies extoling its ability to mitigate various degenerative ailments now exist in both the scientific and the popular literature...
January 1, 2017: Food and Nutrition Bulletin
Heba N Gad El-Hak, Abdel Raouf A Moustafa, Samira R Mansour
Moringa is multipurpose promising tree particularly for medicinal use. With its high nutritive and pharmaceutical values, every part of the tree is suitable for human consumptions. The use of vegetate parts, seeds or extracts requires toxicological evaluations to prove and verify safety uses before being added to pharmaceutical medicine, or any other products related to human diet. In this study, Moringa peregrina seeds, grown in high elevation mountain in Saint Catherin area, were investigated and evaluated for their toxicity with respect to its topological potential through histological and biochemical studies in Albino rats...
2018: Toxicology Reports
Ismail Ishola, Charles Anunobi, Kayode Yemitan, Olasunmbo Afolayan, Tobi Durojaiye
OBJECTIVE: This study sought to evaluate the protective effect of ethanolic leaf extract of Moringa Oleifera (M. oleifera ) on testosterone-induced benign prostatic hyperplasia (BPH) in male Sprague-Dawley rats. MATERIALS AND METHODS: BPH was induced in rats by administration of testosterone propionate (3 mg/kg, s.c., in olive oil) for 4 weeks. M. oleifera (50, 100 or 200 mg/kg), celecoxib (20 mg/kg) or M. oleifera (50 mg/kg) + celecoxib (20 mg/kg) were orally administered daily 15 min before testosterone...
December 17, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Cristhyane M Freita, Lidyane A Freita, Leticia F Tralli, Aline F Silva, Franciele Q Mendes, Vitor Teixeira, Marcia J R Mutton
One of the most important steps is to clarify the juice, which are added synthetic polymer acrylamide base, aiming the fast settling of impurities present in the juice. However, this input is expensive and may have carcinogenic and neurotoxic actions to humans. The search for new natural flocculants that have similarity with the commercial product is of great value. A bioextract that may be promising and has coagulant action is the Moringa oleifera Lam. In this context, the objective of the research was to evaluate the consequences of the use of moringa seed extracts and various concentrations of commercial polymer, such as sedimentation aids in clarifying sugarcane juice in the ethanol production, comparing the efficiency of the bioextract moringa...
December 11, 2017: Anais da Academia Brasileira de Ciências
Karim Raafat, Fadi Hdaib
OBJECTIVES: To explore the phytotherapeutic-activities of Moringa oleifera (MO) seeds on painful diabetic neuropathy in alloxan-induced diabetic mice. METHODS: The bio-guided fractionation of MO utilizing column chromatography aided with GC-MS was used to detect the most active constituent of MO. Hyperalgesia, using tail-flick and hot-plate latency experiments, and mechanical-allodynia, utilizing von-Frey filaments, were evaluated before and after 8 weeks of intraperitoneal alloxan administration (180 mg/kg)...
December 12, 2017: Chinese Journal of Integrative Medicine
Baljit Singh, Ajay Kumar
The present article is an attempt to explore the potential of the Moringa oleifera gum polysaccharides in network formation with poly(acrylic acid) by radiation induced crosslinking to develop the hydrogel for slow drug delivery applications. Polymers were characterized by Cryo-SEM, AFM and 13C NMR techniques. Furthermore, drug delivery, network formation and some biomedical properties like blood compatibility, antioxidant activity, mucoadhesion and gel strength of the hydrogels were also determined. The release of ciprofloxacin occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas kinetic model...
December 7, 2017: International Journal of Biological Macromolecules
Frances E Williams, Andrew K Lee, Sanaz Orandi, Sarah K Sims, David M Lewis
Moringa oleifera seeds are well known for their ability to cause flocculation in turbid water and facilitate bacterial inhibition. These effects are due to the cationic polypeptide MO2.1, which affects the surface charge of suspended particles and causes lysis of bacterial cells. However, the attachment of bacteria to MO2.1 prevents further bacterial attachment, reducing the effectiveness of the seeds. This research investigated the effect of surfactants on functionality and reuse of Moringa seeds to develop a sustainable water treatment technique...
October 2017: Journal of Water and Health
Sina Feustel, Fabiola Ayón-Pérez, Ana Sandoval-Rodriguez, Roberto Rodríguez-Echevarría, Homero Contreras-Salinas, Juan Armendáriz-Borunda, L V Sánchez-Orozco
Chronic hepatitis B infection treatment implicates a long-lasting treatment. M. oleifera extracts contain compounds with antiviral, antioxidant, and antifibrotic properties. In this study, the effect of M. oleifera was evaluated in Huh7 cells expressing either HBV genotypes C or H for the antiviral, antifibrotic, anti-inflammatory, and antioxidative responses. Huh7 cells were treated with an aqueous extract of M. oleifera (leaves) at doses of 0, 30, 45, or 60 μg/mL. The replicative virus and TGF-β1, CTGF, CAT, IFN-β1, and pgRNA expressions were measured by real time...
2017: Journal of Immunology Research
Ibrahim Salameh Al-Majali, Sawsan Atallah Al-Oran, Mona Rushdie Hassuneh, Haitham Naief Al-Qaralleh, Walid Abu Rayyan, Osama Yosef Al-Thunibat, Eyad Mallah, Ahmed Abu-Rayyan, Shadi Salem
This study was conducted to assess the in vivo and ex vivo immunomodulatory effect of the ethanol leaves extract of Moringa peregrina in Balb/c mice. For this study, five groups of 5 Balb/c mice were given a single acute subtoxic oral dose of the ethanolic extract at 1.13, 11.30, 23.40 and 113.4 mg/kg and the immunomodulatory effect was assessed on the 6th day following the ingestion. In the (non-functional) assessment, the effect of the extract on the body weight, relative lymphoid organ weight, splenic cellularity and peripheral blood hematologic parameters were evaluated...
2017: Central-European Journal of Immunology
Nancy Gisela González Garza, Janice Azucena Chuc Koyoc, Jorge Ariel Torres Castillo, Eduardo Alejandro García Zambrano, David Betancur Ancona, Luis Chel Guerrero, Sugey Ramona Sinagawa García
Moringa oleifera (Moringaceae) is a specie of significant importance because of its multiple nutraceutical properties, that has led to increase in its consumption. The seeds contain a high percentage of protein (37.48%). However, little is known about the bioactive properties of these proteins and peptides, especially those generated by enzymatic hydrolysis. The objective of this study was to evaluate the biofunctional properties of total hydrolysates (TH) and peptide fractions from protein isolates of moringa seeds...
December 2017: Journal of Food Science and Technology
W M Dimuthu Nilmini Wijeyaratne, Suvendran Subanky
Chunnakam and Vadamaradchi are two major aquifer systems in Jaffna Peninsula, Sri Lanka. This study was performed to compare water quality in the domestic wells in these aquifers and to assess the efficacy of household water treatments for treating contaminated water. Replicate well water samples were collected from each aquifer and pH, dissolved oxygen (DO), conductivity, total dissolved solids (TDS), salinity, temperature, total solids (TS), total hardness (TH), chemical oxygen demand (COD), oil and grease (OG), nitrate N (N), and total phosphate (TP) were measured...
2017: Scientifica
Adepoju-Bello Aa, Jolayemi Om, Ehianeta Ts, Ayoola Ga
Moringa oleifera plant has been widely used for a vast number of folkloric medicinal purposes. The research aimed to investigate the antioxidant and antihyperglycaemic activity of Moringa oleifera leaf extracts obtained using different solvent systems for extraction. The solvent extracts of Moringa oleifera were: water extract (100% MoWE), 50% Methanolic extract (50% MoME), 100% Methanolic extract (100% MoME), 50% Ethanolic extract (50% MoEE), and 100% Ethanolic extract (100% MoEE). The in vitro antioxidant activity was evaluated by the use of the 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging assay which showed the hydro-alcoholic extracts to have the highest reducing power, though lower than that of the standard, vitamin C...
November 2017: Pakistan Journal of Pharmaceutical Sciences
Ishrat Younus, Muhammad Ashraf, Anab Fatima, Imran Altaf, Aqeel Javeed
Cytotoxic and antiviral activity of aqueous leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus (FMDV) were determined using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Eight different concentrations of each plant were evaluated. Cytotoxic and antiviral activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. From the tested plant extracts, Azadirachta indica & Moringa oleifera exhibited cytotoxicity at 200 & 100 μ/ml respectively...
November 2017: Pakistan Journal of Pharmaceutical Sciences
Maher Mahmoud Al-Dabbas
The antioxidant activities of methanol (M), ethyl acetate (E) and hexane (H) extracts from leaves (L) and seeds (S) of Moringa (Moringa peregrina) were evaluated using different model systems in vitro. Free radical scavenging activities were assessed by measuring the scavenging activities of leaves and seeds different polar extracts separately using ABTS, Hydroxyl (OH) and DPPH radicals. Effect of extracts on ferrous ions chelating ability and total antioxidant capacity were also investigated for each extract...
November 2017: Pakistan Journal of Pharmaceutical Sciences
Sunanda Panda, Anand Kar, Sagarika Biswas
An iridoid glycoside, agnucastoside C (ACC) was isolated from the leaves of Moringa oliefera and its cardio protective potential was investigated in adult rats by examining the effects of this test compound, ACC at 30 mg/kg for 14 days in isoproterenol (100 mg/kg)-induced myocardial injury. Isoproterenol (ISO) administration induced the myocardial injury as evidenced by the altered ECG pattern with ST-segment elevation and an increase in the levels of cardiac injury markers including troponin-I, creatine kinase-MB, alanine transaminase, aspartate transaminase, lactate dehydrogenase; inflammatory markers, interleukine-6 and tumor necrosis factor...
November 23, 2017: Scientific Reports
Wudan Yan
Water on Earth-in our oceans, rivers, lakes, and wetlands-might seem plentiful, but water that is clean and safe enough to drink actually isn't so abundant. Nearly one in ten people still lacks access to safe water worldwide, according to the World Health Organization. In some of the world's most remote and impoverished communities, people live with no taps, showers, flushing toilets, or nearby springs, making it difficult to keep water supplies safe from bacteria, chemicals, and particulates. Moreover, access to clean drinking water isn't just a problem in the developing world; groundwater in developed countries is typically used far more quickly than it is being replenished...
November 2017: IEEE Pulse
Kaleab Taye Haile, Asnakew Achaw Ayele, Abebe Basazn Mekuria, Chilot Abiyu Demeke, Begashaw Melaku Gebresillassie, Daniel Asfaw Erku
BACKGROUND: People living with HIV/AIDS (PLWHA) are increasingly using herbal remedies due to the chronic nature of the disease, the complexities of treatment modalities and the difficulty in adhering to the therapeutic regimens. Yet, research on herbal medicine use in this patient population is scarce in Ethiopia. The present study aimed at investigating the prevalence and factors associated with the use of traditional herbal medicine among PLWHA in Gondar, Ethiopia. METHODS: A cross sectional survey was conducted on 360 PLWHA attending the outpatient clinic of University of Gondar referral and teaching hospital from September 1 to 30, 2016...
December 2017: Complementary Therapies in Medicine
Jegannathan Kenthorai Raman, Catarina M Alves, Edgard Gnansounou
Plants and derivatives have been explored for unlimited purposes by mankind, from crop cultivation for providing food and animal feed, to the use for cosmetics, therapeutics and energy. Moringa tree and vetiver grass features, capabilities and applications were explored through a literature review. The suitability of these plants for the bioenergy industry products is evidenced, namely for bioethanol, biogas and biodiesel, given the lignocellulosic biomass content of these plants and characteristics of moringa seed oil...
October 31, 2017: Bioresource Technology
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