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https://www.readbyqxmd.com/read/27897229/global-gene-regulation-during-activation-of-immunoglobulin-class-switching-in-human-b-cells
#1
Youming Zhang, David J Fear, Saffron A G Willis-Owen, William O Cookson, Miriam F Moffatt
Immunoglobulin class switch recombination (CSR) to IgE is a tightly regulated process central to atopic disease. To profile the B-cell transcriptional responses underlying the activation of the germinal centre activities leading to the generation of IgE, naïve human B-cells were stimulated with IL-4 and anti-CD40. Gene expression and alternative splicing were profiled over 12 days using the Affymetrix Human Exon 1.0 ST Array. A total of 1,399 genes, forming 13 temporal profiles were differentially expressed...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890087/molecular-phylogeny-diversity-community-structure-and-plant-growth-promoting-properties-of-fungal-endophytes-associated-with-the-corms-of-saffron-plant-an-insight-into-the-microbiome-of-crocus-sativus-linn
#2
Zahoor Ahmed Wani, Dania Nazir Mirza, Palak Arora, Syed Riyaz-Ul-Hassan
A total of 294 fungal endophytes were isolated from the corms of Crocus sativus at two stages of crocus life cycle collected from 14 different saffron growing sites in Jammu and Kashmir (J & K) State, India. Molecular phylogeny assigned them into 36 distinct internal transcribed spacer (ITS) genotypes which spread over 19 genera. The diversity of endophytes was higher at the dormant than at the vegetative stage. The Saffron microbiome was dominated by Phialophora mustea and Cadophora malorum, both are dark septate endophytes (DSEs)...
December 2016: Fungal Biology
https://www.readbyqxmd.com/read/27889767/crocetin-inhibits-lipopolysaccharide-induced-inflammatory-response-in-human-umbilical-vein-endothelial-cells
#3
Lei Song, Chen Kang, Yuan Sun, Wenrui Huang, Wei Liu, Zhiyu Qian
BACKGROUND/AIM: Crocetin is a readily bioavailable and bioactive compound extracted from Saffron. Previous studies indicated its various biomedical properties including antioxidant and anti-coagulation potencies. However, its effect on inflammation, notably within the cardiovascular system, has not been investigated yet. In the present study, we utilized human umbilical vein endothelial cell (HUVEC) to elucidate the effect of Crocetin on vascular inflammation. METHODS: Cell viability and toxicity were evaluated by MTT and Lactate dehydrogenase (LDH) assay, respectively...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#4
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27878253/development-of-a-therapeutic-model-of-precancerous-liver-using-crocin-coated-magnetite-nanoparticles
#5
Rkia El-Kharrag, Amr Amin, Soleiman Hisaindee, Yaser Greish, Sherif M Karam
Despite considerable advances in understanding hepatocellular carcinoma, it is one of the common and deadliest cancers worldwide. Hence, increasing efforts are needed for early diagnosis and effective treatments. Saffron has been recently found to inhibit growth of liver cancer in rats. The aim of this study was to develop an effective method for treatment of liver cancer using magnetite nanoparticles (MNPs) coated with crocin, the main active component of saffron. MNPs were prepared and initially coated with dextran and a cross-linker to enhance conjugation of crocin using a modified coprecipitation method...
November 15, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27865956/safranal-and-its-analogs-inhibit-escherichia-coli-atp-synthase-and-cell-growth
#6
Mason Liu, Amon Amini, Zulfiqar Ahmad
Safranal, a dominant component of saffron, is known to have antitumor, cytotoxic, and antibacterial properties. In this study, we examined safranal and its structural analogs-thymol, carvacrol, damascenone, cuminol, 2,6,6-trimethyl-2-cyclohexene-1,4-dione (TMCHD), 4-isopropylbenzyl bromide (IPBB), and 4-tert-butylphenol (TBP) induced inhibition of Escherichia coli membrane bound F1Fo ATP synthase. Safranal and its analogs inhibited wild-type enzyme to variable degrees. While safranal caused 100% inhibition of wild-type F1Fo ATP synthase, only about 50% inhibition occurred for αR283D mutant ATP synthase...
November 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27865556/trans-crocetin-improves-amyloid-%C3%AE-degradation-in-monocytes-from-alzheimer-s-disease-patients
#7
Roberto Tiribuzi, Lucia Crispoltoni, Valerio Chiurchiù, Antonella Casella, Celeste Montecchiani, Alberto Marco Del Pino, Mauro Maccarrone, Carlo Alberto Palmerini, Carlo Caltagirone, Toshitaka Kawarai, Aldo Orlacchio, Antonio Orlacchio
Herbal medicines have been recently employed in research and clinical studies for the potential treatment of behavioral and psychological symptoms associated with Alzheimer's Disease (AD) and other types of dementia. The present study investigates the effect of trans-crocetin, an active constituent of Crocus sativus L., to restore in vitro the reduced ability of AD patients' monocytes to degrade amyloid-β(1-42) (Aβ42). CD14(+) monocytes from 22 sporadic AD patients with moderate cognitive impairment were isolated; then, the role of trans-crocetin, purified from saffron extracts, was evaluated in terms of Aβ42 degradation rate through flow cytometry, as well as expression of cathepsin B by Western blotting...
November 6, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27861946/saffron-a-promising-natural-medicine-in-the-treatment-of-metabolic-syndrome
#8
REVIEW
Bibi Marjan Razavi, Hossein Hosseinzadeh
Metabolic syndrome is a disorder which encompasses with obesity, high blood glucose, high cholesterol levels and high blood pressure. Moreover metabolic syndrome is considered as the most important risk factor for cardiovascular disease (CVD). CVD is the leading cause of mortality in the world for both men and women. Although several chemical drugs are available to treat metabolic risk factors, however, because of the safety, efficacy, cultural acceptability and lesser side effects, nowadays herbal therapy has a critical role in the treatment of these CVD risk factors...
November 12, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27861558/modulation-of-type-1-and-type-2-cannabinoid-receptors-by-saffron-in-a-rat-model-of-retinal-neurodegeneration
#9
Rita Maccarone, Cinzia Rapino, Darin Zerti, Monia di Tommaso, Natalia Battista, Stefano Di Marco, Silvia Bisti, Mauro Maccarrone
Experimental studies demonstrated that saffron (Crocus sativus) given as a dietary supplement counteracts the effects of bright continuous light (BCL) exposure in the albino rat retina, preserving both morphology and function and probably acting as a regulator of programmed cell death [1]. The purpose of this study was to ascertain whether the neuroprotective effect of saffron on rat retina exposed to BCL is associated with a modulation of the endocannabinoid system (ECS). To this aim, we used eight experimental groups of Sprague-Dawley rats, of which six were exposed to BCL for 24 hours...
2016: PloS One
https://www.readbyqxmd.com/read/27842483/patents-on-therapeutic-and-cosmetic-applications-of-bioactives-of-crocus-sativus-l-and-their-production-through-synthetic-biology-methods-a-review
#10
Mitali Nitin Dawalbhakta, Manasi Alok Telang
BACKGROUND: Saffron (Crocus sativus L.) has a long history of use as a food additive and a traditional medicine for treating a number of disorders. Prominent bioactives of saffron are crocin, crocetin and safranal. OBJECTIVE: The aim of this study was to carry out an extensive patent search to collect information on saffron bioactives and their derivatives as therapeutic and cosmeceutical agents. All patents related to the area of interest published globally till date have been reviewed...
November 14, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27811707/taxonomic-revision-of-saffron-billed-sparrow-arremon-flavirostris-swainson-1838-aves-passerellidae-with-comments-on-its-holotype-and-type-locality
#11
Nelson Buainain, Guilherme Renzo Rocha Brito, Daniel Honorato Firme, Daniel Monteiro Figueira, Marcos A Raposo, Claydson Pinto De Assis
The Saffron-billed Sparrow (Arremon flavirostris) complex occurs in the undergrowth of deciduous woodlands and forests from the Andes of Bolivia and northern Argentina to Paraguay and southern, mid-western and interior eastern Brazil. Currently four subspecies are recognized: A. f. flavirostris, A. f. polionotus, A. f. devillii and A. f. dorbignii. We review the taxonomy of this complex by analyzing coloration and morphometrics of a series of 234 skins, and by comparing 101 sound recordings. Our results suggest that under both the Phylogenetic and Biological Species Concept, three species should be recognized in this complex: A...
October 26, 2016: Zootaxa
https://www.readbyqxmd.com/read/27792130/vitamin-e-turmeric-and-saffron-in-treatment-of-alzheimer-s-disease
#12
REVIEW
Nur Adalier, Heath Parker
Alzheimer's disease (AD) is a growing epidemic and currently there is no cure for the disease. The disease has a detrimental effect on families and will strain the economy and health care systems of countries worldwide. The paper provides a literature review on a few ongoing possible antioxidant therapy treatments for the disease. The paper highlights use of vitamin E, turmeric and saffron for an alternative antioxidant therapy approach. Clinical studies report their therapeutic abilities as protective agents for nerve cells against free radical damage, moderating acetylcholinesterase (AChE) activity and reducing neurodegeneration, which are found as key factors in Alzheimer's...
October 25, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27770798/protective-effects-of-saffron-extract-and-crocin-supplementation-on-fatty-liver-tissue-of-high-fat-diet-induced-obese-rats
#13
Maryam Mashmoul, Azrina Azlan, Norhafizah Mohtarrudin, Barakatun Nisak Mohd Yusof, Huzwah Khaza'ai, Hock Eng Khoo, Mehdi Farzadnia, Mohammad Taher Boroushaki
BACKGROUND: Saffron is the dried stigma of Crocus sativus L. flower which commonly used as a natural remedy to enhance health and even fights disease in the Middle-East and Southeast Asian countries. METHODS: This study was aimed to investigate protective effect of saffron extract and crocin in fatty liver tissue of high-fat diet induced obese rats. A total of 36 healthy male Sprague Dawley rats were divided into six groups. Two groups served as controls, a normal diet (ND) and a high-fat diet (HFD)...
October 22, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27769229/herbal-remedies-and-functional-foods-used-by-cancer-patients-attending-specialty-oncology-clinics-in-trinidad
#14
Yuri N Clement, Varune Mahase, Annelise Jagroop, Kelly Kissoon, Aarti Maharaj, Prashant Mathura, Chrys Mc Quan, Divya Ramadhin, Cherrista Mohammed
BACKGROUND: Cancer is a major disease worldwide, and many patients use complementary and alternative treatments. The purpose of this study was to identify the herbal remedies and functional foods used as complementary medicine by prostate, breast and colorectal cancer patients at speciality care facilities in Trinidad. We also sought to determine how patients rated the efficacy of these modalities compared with conventional treatment. METHODS: A descriptive, cross-sectional survey was conducted using an interviewer-administered pilot-tested de novo questionnaire during the period June to August 2012 at two speciality treatment centres on the island...
October 21, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27765245/geographical-identification-of-saffron-crocus-sativus-l-by-linear-discriminant-analysis-applied-to-the-uv-visible-spectra-of-aqueous-extracts
#15
Angelo Antonio D'Archivio, Maria Anna Maggi
We attempted geographical classification of saffron using UV-visible spectroscopy, conventionally adopted for quality grading according to the ISO Normative 3632. We investigated 81 saffron samples produced in L'Aquila, Città della Pieve, Cascia, and Sardinia (Italy) and commercial products purchased in various supermarkets. Exploratory principal component analysis applied to the UV-vis spectra of saffron aqueous extracts revealed a clear differentiation of the samples belonging to different quality categories, but a poor separation according to the geographical origin of the spices...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27723543/efficacy-of-curcumin-and-a-saffron-curcumin-combination-for-the-treatment-of-major-depression-a-randomised-double-blind-placebo-controlled-study
#16
Adrian L Lopresti, Peter D Drummond
BACKGROUND: Several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. However, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. Furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown. METHODS: In a randomised, double-blind, placebo-controlled study, 123 individuals with major depressive disorder were allocated to one of four treatment conditions, comprising placebo, low-dose curcumin extract (250mg b...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27701683/crocus-sativus-l-versus-citalopram-in-the-treatment-of-major-depressive-disorder-with-anxious-distress-a-double-blind-controlled-clinical-trial
#17
A Ghajar, S M Neishabouri, N Velayati, L Jahangard, N Matinnia, M Haghighi, A Ghaleiha, M Afarideh, S Salimi, A Meysamie, S Akhondzadeh
Introduction: Saffron (Crocus sativus L.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. Methods: 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. Results: 60 participants finished the study...
October 4, 2016: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27696408/widespread-brain-transcriptome-alterations-underlie-the-neuroprotective-actions-of-dietary-saffron
#18
Nicholas V Skladnev, Varshika Ganeshan, Ji Yeon Kim, Thomas J Burton, John Mitrofanis, Jonathan Stone, Daniel M Johnstone
Dietary saffron has shown promise as a neuroprotective intervention in clinical trials of retinal degeneration and dementia and in animal models of multiple CNS disorders, including Parkinson's disease. This therapeutic potential makes it important to define the relationship between dose and protection and the mechanisms involved. To explore these two issues, mice were pre-conditioned by providing an aqueous extract of saffron (0.01% w/v) as their drinking water for 2, 5 or 10 days before administration of the parkinsonian neurotoxin MPTP (50 mg/kg)...
October 1, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27680892/crocin-protects-human-erythrocytes-from-nitrite-induced-methemoglobin-formation-and-oxidative-damage
#19
Fariheen Aisha Ansari, Shaikh Nisar Ali, Riaz Mahmood
Sodium nitrite (NaNO2 ) is a common contaminant of drinking water and food and feed chain. Nitrite induces oxidative damage in humans and animals. In this work, we studied the protective effect of crocin, the active constituent of Crocus sativus (saffron), on NaNO2 -induced oxidative damage in human erythrocytes. Changes in oxidative stress parameters following NaNO2 incubation of erythrocytes in presence and absence of crocin were determined. It was found that crocin pre-treatment significantly attenuated NaNO2 -induced oxidative damage of proteins, lipids, and plasma membrane...
September 28, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27664699/corrigendum-to-saffron-authentication-based-on-liquid-chromatography-high-resolution-tandem-mass-spectrometry-and-multivariate-data-analysis-food-chem-204-2016-201-209
#20
Josep Rubert, Ondrej Lacina, Milena Zachariasova, Jana Hajslova
No abstract text is available yet for this article.
February 15, 2017: Food Chemistry
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