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https://www.readbyqxmd.com/read/28643510/characterization-of-the-saffron-derivative-crocetin-as-an-inhibitor-of-human-lactate-dehydrogenase-5-in-the-antiglycolytic-approach-against-cancer
#1
Carlotta Granchi, Serena Fortunato, Serena Meini, Flavio Rizzolio, Isabella Caligiuri, Tiziano Tuccinardi, Hyang Yeon Lee, Paul J Hergenrother, Filippo Minutolo
Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 µM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC50 = 114...
June 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28637418/anti-inflammatory-effect-of-crocus-sativus-on-the-serum-cytokines-levels-in-subjects-with-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-trial
#2
Tayebe Kermani, Maedeh Zebarjadi, Hassan Mehrad-Majd, Seyed-Reza Mirhafez, Maryam Shemshian, Faezeh Ghasemi, Elham Mohammadzadeh, Seyed Hadi Mousavi, Abdolreza Norouzy, Toktam Moghiman, Akram Sadeghi, Gordon Ferns, Amir Avan, Elaheh Mahdipour, Majid Ghayour-Mobarhan
BACKGROUND/AIMS: A growing body of evidence supports an important role of inflammatory-cytokines in development and progression of metabolic-syndrome (MetS), which explain, at least in part, its relationship with an increased cardiovascular-risk. Several studies have reported the therapeutic-impact of crocus-sativus in preclinical/clinical setting. Here we have explored the effects of crocus-sativus, saffron, on the modulation of twelve serum cytokines in subjects with MetS in a randomized control trial...
June 21, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28629221/extracted-apocarotenoids-from-saffron-stigmas-and-evaluated-the-quality-of-saffron
#3
Feng Xiaobin, Qian Xiaodong, Han Shuwen, Yao Chong, Yuan Yumei, Zhou Guifen
Saffron is a kind of expensive spice and therapeutic agent. In order to establish a set of methods to evaluate the quality of saffron, High Performance Liquid Chromatography/Mass Spectrometry (HPLC/MS) were used to identify the apocarotenoids extracted from saffron stigmas. TOPSIS method was applied to evaluate the qualities of saffron. The conditions of HPLC/MS and chemical fingerprints of saffron had been established. The 14 chromatographic peaks and 13 main apocarotenoids of saffron with high reproducibility, stability and specificity were confirmed...
June 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28627891/effect-of-deep-eutectic-solvent-nanostructure-on-phospholipid-bilayer-phases
#4
Saffron Jade Bryant, Rob Atkin, Gregory G Warr
Phospholipids are shown by solvent penetration experiments to form lamellar phases and spontaneously spawn vesicles in a wide range of deep eutectic solvents (DESs) composed of alkylammonium halide salts and glycerol or ethylene glycol, which are shown to be nanostructured by X-ray scattering. In contrast with molecular solvents, the chain melting temperature of each phospholipid, which determines the stability of the swellable bilayer phase, depends on the structure of the cation, anion and molecular H-bond donor that constitute the DES...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28625892/consumers-acceptance-of-medicinal-herbs-an-application-of-the-technology-acceptance-model-tam
#5
Nargesh Khatun Jokar, Seyyed Ali Noorhosseini, Mohammad Sadegh Allahyari, Christos A Damalas
ETHNOPHARMACOLOGICAL RELEVANCE: The shift in consumers' preferences from synthetic to 'natural' products has led to a resurgence of interest in medicinal plants, particularly in developing countries. However, research data about consumers' preferences for particular products is hard to find. AIMS AND OBJECTIVES: The main objective of this study was to contribute to the general understanding of consumers' intention for selecting medicinal herbs for consumption. MATERIALS AND METHODS: Factors underpinning consumers' acceptance of medicinal herbs were studied with the technology acceptance model (TAM) in Rasht City of Iran using a structured questionnaire...
June 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28602167/mechanism-behind-the-anti-tumour-potential-of-saffron-crocus-sativus-l-the-molecular-perspective
#6
REVIEW
Sweta Patel, Maryam Sarwat, Tajdar H Khan
Cancer is a disorder which has noted a significant rise in incidence worldwide and continues to be the largest cause of mortality. It has a dramatic impact on human life expectancy and quality of life in spite of the increase in technology and the treatments available for cancer patients. These new therapeutic options being chemotherapy, radiotherapy, photolytic therapy and catalytic therapy are known to have many adverse reactions and also no better positive outcomes than before. Hence, research is now focused more on utilizing the vast repertoire of traditional medicinal knowledge i...
July 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28577148/assessing-energy-efficiencies-economy-and-global-warming-potential-gwp-effects-of-major-crop-production-systems-in-iran-a-case-study-in-east-azerbaijan-province
#7
Arash Mohammadzadeh, Abdolmajid Mahdavi Damghani, Javad Vafabakhsh, Reza Deihimfard
Efficient use of energy in farming systems is one of the most important implications for decreasing greenhouse gas (GHG) emissions and mitigating global warming (GW). This paper describes the energy use patterns, analyze the economics, and report global warming potential effects of major crop production systems in East Azerbaijan province, Iran. For this purpose, 110 farmers whose main activity was major crop production in the region, including wheat, barley, carrot, tomato, onion, potato, alfalfa, corn silage, canola, and saffron, were surveyed...
June 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28570542/expression-purification-and-antimicrobial-activity-of-s100a12
#8
Emmanuel Jackson, Saffron Little, Dana S Franklin, Jennifer A Gaddy, Steven M Damo
Calgranulin proteins are important mediators of innate immunity and are members of the S100 class of the EF-hand family of calcium binding proteins. Some S100 proteins have the capacity to bind transition metals with high affinity and effectively sequester them away from invading microbial pathogens in a process that is termed "nutritional immunity". S100A12 (EN-RAGE) binds both zinc and copper and is highly abundant in innate immune cells such as macrophages and neutrophils. We report a refined method for the expression, enrichment and purification of S100A12 in its active, metal-binding configuration...
May 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28554638/effect-of-cold-plasma-on-crocin-esters-and-volatile-compounds-of-saffron
#9
Maryam Amini, Mahmood Ghoranneviss, Sara Abdijadid
The effect of cold plasma on crocin esters and volatile oils of saffron was studied for the first time. After the treatments, (Ar, Ar/5% O2 and Ar/10% O2 at 8 and 12kV of voltage), a decrease in crocin esters and saffranal and an increase in isophorone and 4-ketoisophorone was observed. After 4min, the saffron samples treated with Ar/20% O2 had blackened and the treatment was discontinued. The results show that increasing the input voltage and increasing the amount of added oxygen to Argon gas increased the changes in the safranal and crocin esters...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28552059/the-role-of-saffron-in-attenuating-age-related-oxidative-damage-in-rat-hippocampus
#10
Saeed Samarghandian, Mohsen Azimi Nezhad, Fariborz Samini, Tahereh Farkhondeh
BACKGROUND: Using antioxidant diets may be a good strategy for the inhibition of oxidative stress connected to age-related disease. Saffron is a dried stigmas of with antioxidant properties. This investigation was done to study the effects of saffron administration on lipid peroxidation and antioxidant status in hippocampus of male aged rats. The rats were treated with the ethanolic extract of saffron for 4 weeks. At the end of our investigation, the hippocampi of rats were removed. The homogenate was used for evaluation of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxides (GPx), catalase (CAT) and glutathione (GSH)...
May 28, 2017: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/28550283/high-resolution-bioelectrical-imaging-of-a%C3%AE-induced-network-dysfunction-on-cmos-meas-for-neurotoxicity-and-rescue-studies
#11
Hayder Amin, Thierry Nieus, Davide Lonardoni, Alessandro Maccione, Luca Berdondini
Neurotoxicity and the accumulation of extracellular amyloid-beta1-42 (Aβ) peptides are associated with the development of Alzheimer's disease (AD) and correlate with neuronal activity and network dysfunctions, ultimately leading to cellular death. However, research on neurodegenerative diseases is hampered by the paucity of reliable readouts and experimental models to study such functional decline from an early onset and to test rescue strategies within networks at cellular resolution. To overcome this important obstacle, we demonstrate a simple yet powerful in vitro AD model based on a rat hippocampal cell culture system that exploits large-scale neuronal recordings from 4096-electrodes on CMOS-chips for electrophysiological quantifications...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546803/effect-of-tribulus-terrestris-ginger-saffron-and-cinnamomum-on-menopausal-symptoms-a-randomised-placebo-controlled-clinical-trial
#12
Simin Taavoni, Neda Nazem Ekbatani, Hamid Haghani
Menopausal symptoms experienced by women vary widely, and while many women transition through menopause with manageable symptoms, others experience severe symptoms, which may impair their quality of life. The purpose of this study was to determine the effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms. A randomised, triple-blind, controlled trial design was used for this study. The participants were 80 postmenopausal women aged 50-60 years. A demographic data form and the Menopause Rating Scale were used to collect data...
March 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28537197/saffron-carotenoids-crocin-and-crocetin-binding-to-human-serum-albumin-as-investigated-by-different-spectroscopic-methods-and-molecular-docking
#13
Moslem Jafarisani, S Zahra Bathaie, Mir F Mousavi
Therapeutic effects of saffron ingredients were studied in some diseases. The pharmacokinetics and pharmacodynamics of these ingredients were also studied, but their transport mechanism is not clearly known. Serum albumin has been known as the most important transporter of many drugs in the body that affects their disposition, transportation, and bioavailability. Here, we investigated the interaction of crocin (Cro) with HSA, for the first time, and compared with the crocetin (Crt)-HSA interaction. UV and fluorescence spectroscopy, circular dichroism (CD), and molecular docking was applied to investigate the possibility and mechanism of binding of HSA with these natural carotenoids...
June 8, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28529733/metabolic-effects-of-crocus-sativus-and-protective-action-against-non-alcoholic-fatty-liver-disease-in-diabetic-rats
#14
Panagiotis Konstantopoulos, Ilias P Doulamis, Aspasia Tzani, Maria-Laskarina Korou, Emmanouil Agapitos, Ioannis S Vlachos, Vasilios Pergialiotis, Christos Verikokos, George Mastorakos, Nicholas L Katsilambros, Despina N Perrea
Non-alcoholic fatty liver disease (NAFLD) is the result of the accumulation of adipose tissue deposits in the liver and it is associated with type 2 diabetes. Crocus sativus (saffron) is known for its antioxidant and its potential hypoglycemic effects. We investigated the role of saffron on NAFLD in diabetic rats. Thirty adult male rats were allocated into three groups; control (n=10), which received normal diet; streptozotocin (STZ) group (n=10), which received normal chow diet, 10% fructose in their drinking water and STZ (40 mg/kg body weight; STZ-saffron group (n=10), which followed the same dietary and pharmacological pattern as STZ group and were additionally supplemented with saffron (100 mg/kg/day)...
May 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28511420/effect-of-intraperitoneal-injection-of-saffron-on-the-treatment-of-experimental-endotoxin-induced-uveitis-in-the-rabbit
#15
Mohammad Reza Talebnejad, Kazem Soltanzadeh, Eghtedari Masoomeh, Masoud Yasemi, Mohammad Reza Khalili, Sherafat Maryam
INTRODUCTION: Saffron with scientific name of "Crocus sativus" from the family "Iridaceae" is a plant without stem and root. Antioxidative and immunomodulatory effects of saffron has been demonstrated in different studies. AIM: To assess the effects of saffron in the treatment on Lipopolysaccharide (LPS) induced uveitis in the rabbit. MATERIALS AND METHODS: Thirty healthy female New Zealand white rabbits were prepared. LPS induced uveitis was confirmed via slit lamp examination 24 hours after intravitreal injection of Salmonella typhimurium LPS endotoxin in the right eye of all rabbits...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506128/a-review-of-curcumin-as-a-biological-stain-and-as-a-self-visualizing-pharmaceutical-agent
#16
M Hope-Roberts, R W Horobin
Curcumin has been widely used to color textiles but, unlike other natural dyes such as hematoxylin or saffron, it rarely has been discussed as a biological stain. Aspects of the physicochemistry of curcumin relevant to biological staining and self-visualization, i.e., its acidic properties, lipophilicity, metal and pseudometal complexes, and optical properties, are summarized briefly here. Reports of staining of non-living biological specimens in sections and smears, both fixed and unfixed, including specimens embedded in resin, are summarized here...
May 16, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28503046/reflections-about-osteoarthritis-and-curcuma-longa
#17
REVIEW
Marina Cristina Akuri, Sandra Maria Barbalho, Raíssa Meira Val, Elen Landgraf Guiguer
Osteoarthritis (OA) is a chronic inflammatory degenerative process that affects joints such as the hands, hips, shoulders, feet, spine, and especially knees in millions of people worldwide. Some authors have shown that Curcuma longa components may exhibit benefic effects in the treatment of degenerative diseases as OA. This plant belongs to the family Zingiberaceae and it is popularly known as turmeric or saffron. This review intended to perform a retrospective search to identify studies involving humans and animal models...
January 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28496478/study-of-crocin-radiotherapy-induced-cytotoxicity-and-apoptosis-in-the-head-and-neck-cancer-hn-5-cell-line
#18
Vahid Vazifedan, Seyed Hadi Mousavi, Javad Sargolzaei, Shokouhozaman Soleymanifard, Azar Fani Pakdel
Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. Chemo radiotherapy is the standard treatment for head and neck cancer. In the present study, the cytotoxic effects, inducing apoptosis and the radiation sensitivity of crocin were evaluated in the head and neck cancer cell line (HN-5)...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28496474/enhancement-of-antinociceptive-effect-by-co-administration-of-amitriptyline-and-crocus-sativus-in-a-rat-model-of-neuropathic-pain
#19
Bahareh Amin, Samira Hosseini, Hossein Hosseinzadeh
The aim of this study was to evaluate the anti-nociceptive effects of a low, sub-effective dose of amitriptyline, in combination with the different doses of ethanolic and aqueous extracts of Crocus sativus following sciatic nerve chronic constriction injury (CCI) in rats. Amitriptyline (3, 10 and 30 mg/Kg, i.p.) and the extracts (25, 50 and 100 mg/Kg, i.p.), were separately administered at the time of CCI for 7 consecutive days. In combination therapy, the sub-antinociceptive dose of amitriptyline (3 mg/Kg) was given with the three different doses of extracts for seven days...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28496464/using-%C3%A3-cyclodextrin-and-arabic-gum-as-wall-materials-for-encapsulation-of-saffron-essential-oil
#20
Mohsen Atefi, Kooshan Nayebzadeh, Abdorreza Mohammadi, Amir Mohammad Mortazavian
Saffron essential oil has a pleasant aroma and medicinal activities. However, it is sensible into the environmental condition. Therefore, it should be protected against unwanted changes during storage or processing. Encapsulation is introduced as a process by which liable materials are protected from unwanted changes. In the present study, different ratios (0:100, 25:75, 50:50, 75:25, and 100:0) of ß-cyclodextrin (ß-CD) and arabic gum (GA) were used as wall martial for encapsulation saffron essential oil...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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