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Vitamin B6

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https://www.readbyqxmd.com/read/28100326/-feeding-difficulty-and-developmental-delay-for-8-months-and-nystagmus-for-4-months-in-an-infant
#1
Jie Zhu, Fei Yu
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive hereditary disease and is a congenital metabolic disorder of neurotransmitter biosynthesis. It is mainly manifested as hypotonia, oculogyric crisis, autonomic dysfunction, and developmental delay. This article reports a boy manifested as delayed motor development, hypotonia, and oculogyric crisis. Gene screening for metabolic disorders revealed new compound heterozygous mutations, c.1063dupA (p.I355fs) and c.250A>C (p.S84R), in the exon of DDC gene...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099184/efficacy-of-vitamin-b6-in-lithium-associated-tremor-a-case-series
#2
Manuel Dias Alves, Laure Varin, Laura M Fiori, Bruno Etain, Jean-Michel Azorin, Raoul Belzeaux
No abstract text is available yet for this article.
January 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28098048/folate-and-vitamin-b12-concentrations-are-associated-with-plasma-dha-and-epa-fatty-acids-in-european-adolescents-the-healthy-lifestyle-in-europe-by-nutrition-in-adolescence-helena-study
#3
I Iglesia, I Huybrechts, M González-Gross, T Mouratidou, J Santabárbara, V Chajès, E M González-Gil, J Y Park, S Bel-Serrat, M Cuenca-García, M Castillo, M Kersting, K Widhalm, S De Henauw, M Sjöström, F Gottrand, D Molnár, Y Manios, A Kafatos, M Ferrari, P Stehle, A Marcos, F J Sánchez-Muniz, L A Moreno
This study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses...
January 18, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28095734/entrapment-efficiency-of-pyridoxine-hydrochloride-in-unilamellar-liposomes-experimental-versus-model-generated-data
#4
Heba Abd-El-Azim, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah
The present study investigates the effect of the preparation method (four methods) and formulation additives (propylene glycol (PG) and cholesterol (CH)) on the entrapment efficiency (EE) of pyridoxine hydrochloride (vitamin B6 (VB6)), representing hydrophilic water-soluble low permeable vitamins, in unilamellar liposomes. The main aim is to compare determined EE with predicted values generated using a web-published, computational model. Results showed that among the different preparation methods, modified film hydration showed significantly higher EE (p < 0...
January 18, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28092359/lysine-relay-mechanism-coordinates-intermediate-transfer-in-vitamin-b6-biosynthesis
#5
Matthew J Rodrigues, Volker Windeisen, Yang Zhang, Gabriela Guédez, Stefan Weber, Marco Strohmeier, Jeremiah W Hanes, Antoine Royant, Gwyndaf Evans, Irmgard Sinning, Steven E Ealick, Tadhg P Begley, Ivo Tews
Substrate channeling has emerged as a common mechanism for enzymatic intermediate transfer. A conspicuous gap in knowledge concerns the use of covalent lysine imines in the transfer of carbonyl-group-containing intermediates, despite their wideuse in enzymatic catalysis. Here we show how imine chemistry operates in the transfer of covalent intermediates in pyridoxal 5'-phosphate biosynthesis by the Arabidopsis thaliana enzyme Pdx1. An initial ribose 5-phosphate lysine imine is converted to the chromophoric I320 intermediate, simultaneously bound to two lysine residues and partially vacating the active site, which creates space for glyceraldehyde 3-phosphate to bind...
January 16, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28089883/identification-and-characterization-of-a-pyridoxal-5-phosphate-phosphatase-in-the-silkworm-bombyx-mori
#6
ShuoHao Huang, CaiYun Han, ZhenQiao Ma, Jie Zhou, JianYun Zhang, LongQuan Huang
Vitamin B6 comprises six interconvertible pyridine compounds, among which pyridoxal 5'-phosphate (PLP) is a coenzyme for over 140 enzymes. PLP is also a very reactive aldehyde. The most well established mechanism for maintaining low levels of free PLP is its dephosphorylation by phosphatases. A human PLP-specific phosphatase has been identified and characterized. However, very little is known about the phosphatase in other living organisms. In this study, a cDNA clone of putative PLP phosphatase was identified from B...
January 10, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28081293/role-of-pyridoxal-5-phosphate-at-the-titanium-implant-interface-in-vivo-increased-hemophilicity-inactive-platelet-adhesion-and-osteointegration
#7
Jung Seung Lee, Kyuri Kim, Joseph P Park, Seung-Woo Cho, Haeshin Lee
Titanium is the most biocompatible inorganic biomaterial with a long history of use in orthopedic and dental implants. However, promoting rapid and effective bone formation and integration onto etched, rough TiO2 surfaces has been a challenging topic. Here, 21 commercially available molecules are examined that met the following criteria: (1) contain phosphonic acid for stable immobilization onto TiO2 surfaces and (2) have a molecular weight less than 500 Da for negligible coating thickness. Of these molecules, the surface immobilization of pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 , dramatically increases the hemophilic property of the surface and accelerated osteointegration in vivo...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28075382/b-vitamin-intake-and-biomarker-status-in-relation-to-cognitive-decline-in-healthy-older-adults-in-a-4-year-follow-up-study
#8
Catherine F Hughes, Mary Ward, Fergal Tracey, Leane Hoey, Anne M Molloy, Kristina Pentieva, Helene McNulty
Advancing age can be associated with an increase in cognitive dysfunction, a spectrum of disability that ranges in severity from mild cognitive impairment to dementia. Folate and the other B-vitamins involved in one-carbon metabolism are associated with cognition in ageing but the evidence is not entirely clear. The hypothesis addressed in this study was that lower dietary intake or biomarker status of folate and/or the metabolically related B-vitamins would be associated with a greater than expected rate of cognitive decline over a 4-year follow-up period in healthy older adults...
January 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28075090/carpal-tunnel-syndrome-diagnosis-and-management
#9
Jennifer Wipperman, Kyle Goerl
Carpal tunnel syndrome, the most common entrapment neuropathy of the upper extremity, is caused by compression of the median nerve as it travels through the carpal tunnel. Classically, patients with the condition experience pain and paresthesias in the distribution of the median nerve, which includes the palmar aspect of the thumb, index and middle fingers, and radial half of the ring finger. Additional clues include positive physical examination findings, such as the flick sign, Phalen maneuver, and median nerve compression test...
December 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/28058725/urinary-metabolomics-of-complete-freund-s-adjuvant-induced-hyperalgesia-in-rats
#10
Yang Liu, Hui Chen, Jun Lu, Youshui Jiang, Rui Yang, Songyan Gao, Xin Dong, Wei Chen
The aim of this study was to demonstrate the differences of metabolomics changes in a hyperalgesia model and find potent biomarkers of hyperalgesia. Seven rats were placed in metabolic cages. An emulsion containing 500 μg of Complete Freund's adjuvant (CFA) was used to induce hyperalgesia. Urine samples were collected prior to the injection of CFA and on post-injection days 1, 3 and 7. Ultraperformance liquid chromatography, coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS), was used for a quantitative analysis of urinary metabolic changes in the CFA-induced hyperalgesia model...
November 5, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28056273/-study-on-the-contribution-rate-of-follow-up-formula-to-the-nutrient-intake-of-infants-and-young-children-aged-7-24-months-in-china
#11
H Z Li, H X Jia, D Liang, T T Deng, L T Niu, J H Han
Objective: To determine the contribution of follow-up formula (FUF) to the nutrient intake of 7-24-month-old infants and young children. Methods: The cluster random sampling method and the convenience sampling method were used in combination, and geographic and economic factors were taken into consideration. Four areas of China (Beijing, Hebei, Guangxi, Guangdong) were selected, with 120 infants chosen from each of these areas (half of which were 7-12 months old, and half were 13-24 months old). A dietary survey was completed by a continuous 24-hour weighing method over two days...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28042413/association-between-nutritional-status-with-spontaneous-abortion
#12
Rahimeh Ahmadi, Saeideh Ziaei, Sosan Parsay
BACKGROUND: Spontaneous abortion is the most common adverse pregnancy outcome. We aimed to investigate a possible link between nutrient deficiencies and the risk of spontaneous abortion. MATERIALS AND METHODS: This case-control study included the case group (n=331) experiencing a spontaneous abortion before 14 weeks of pregnancy and the control group (n=331) who were healthy pregnant women over 14 weeks of pregnancy. The participants filled out Food Frequency Questionnaire (FFQ), in which they reported their frequency of consumption for a given serving of each food item during the past three months, on a daily, weekly or monthly basis...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28007489/proposal-for-a-breakfast-quality-index-for-brazilian-population-rationale-and-application-in-the-brazilian-national-dietary-survey
#13
Jaqueline Lopes Pereira, Michelle Alessandra de Castro, Sinead Hopkins, Carolyn Gugger, Regina Mara Fisberg, Mauro Fisberg
Breakfast has been related to positive nutrition and health outcomes, but criteria for an optimal composition of this meal are not well established. The aim of this study was to propose a breakfast quality index (BQI) for the Brazilian population, and to describe the relationship between breakfast quality, socio-demographic factors, dietary intake at breakfast and for the total day. BQI was constructed based on individual dietary data of 22,279 breakfast consumers, aged 20+ years from the Brazilian National Dietary Survey, a population-based cross-sectional study...
December 19, 2016: Appetite
https://www.readbyqxmd.com/read/28004269/erratum-to-foods-contributing-to-vitamin-b6-folate-and-vitamin-b12-intakes-and-biomarkers-status-in-european-adolescents-the-helena-study
#14
Iris Iglesia, Theodora Mouratidou, Marcela González-Gross, Inge Huybrechts, Christina Breidenassel, Javier Santabárbara, Ligia-Esperanza Díaz, Lena Hällström, Stefaan De Henauw, Frédéric Gottrand, Anthony Kafatos, Kurt Widhalm, Yannis Manios, Denes Molnar, Peter Stehle, Luis A Moreno
No abstract text is available yet for this article.
December 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/28004152/comparative-transcriptomes-reveal-novel-evolutionary-strategies-adopted-by-saccharomyces-cerevisiae-with-improved-xylose-utilization-capability
#15
Wei-Yi Zeng, Yue-Qin Tang, Min Gou, Zhao-Yong Sun, Zi-Yuan Xia, Kenji Kida
Production of ethanol from xylose by recombinant Saccharomyces cerevisiae is suboptimal with slow fermentation rate, compared with that from glucose. In this study, a strain-expressing Scheffersomyces stipitis xylose reductase-xylitol dehydrogenase (XR-XDH) pathway was subjected to adaptive evolution on xylose; this approach generated populations with the significantly improved cell growth and ethanol production rate. Mutants were isolated, and the best one was used for sporulation to generate eight stable mutant strains with improved xylose fermentation ability...
December 21, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27990293/vitamin-levels-in-adults-with-adhd
#16
Elisabeth Toverud Landaas, Tore Ivar Malmei Aarsland, Arve Ulvik, Anne Halmøy, Per Magne Ueland, Jan Haavik
BACKGROUND: Micronutrients containing vitamins are reported to reduce symptom levels in persons with attention-deficit hyperactivity disorder (ADHD), but data on vitamin levels in ADHD are sparse. AIMS: To examine the relationship between vitamin concentrations, ADHD diagnosis and psychiatric symptoms in young adult ADHD patients and controls. METHOD: Eight vitamins and the nicotine metabolite cotinine were analysed in serum samples from 133 ADHD patients and 131 controls aged between 18 and 40, who also reported ADHD symptoms and comorbid conditions...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/27987384/salmonella-typhimurium-ptsj-is-a-novel-mocr-like-transcriptional-repressor-involved-in-regulating-the-vitamin-b6-salvage-pathway
#17
Angela Tramonti, Teresa Milano, Caterina Nardella, Martino L di Salvo, Stefano Pascarella, Roberto Contestabile
The vitamin B6 salvage pathway, involving pyridoxine 5'-phosphate oxidase (PNPOx) and pyridoxal kinase (PLK), recycles B6 vitamers from nutrients and protein turnover to produce pyridoxal 5'-phosphate (PLP), the catalytically active form of the vitamin. Regulation of this pathway, widespread in living organisms including humans and many bacteria, is very important to vitamin B6 homeostasis but poorly understood. Although some information is available on the enzymatic regulation of PNPOx and PLK, little is known on their regulation at the transcriptional level...
December 17, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27982479/hypermethylation-causes-and-consequences-in-skeletal-muscle-myopathy
#18
Avisek Majumder, JyotirmayaBehera, Navena Jeremic, Suresh C Tyagi
A detrimental consequence of hypermethylation is hyperhomocysteinemia (HHcy), that causes oxidative stress, inflammation and matrix degradation, which leads to multi-pathology in different organs. Although, it is well known that hypermethylation leads to overall gene silencing and hypomethylation leads to overall gene activation, the role of such process in skeletal muscle dysfunction during HHcy condition is unclear. In this study, we emphasized the multiple mechanisms including epigenetic alteration by which HHcy causes skeletal muscle myopathy...
December 16, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27981257/assessing-the-efficacy-of-vaginal-hyoscine-butyl-bromide-on-cervical-ripening-prior-to-intrauterine-procedures-a-double-blinded-clinical-trial
#19
Shiva Hadadian, Masoumeh Fallahian
BACKGROUND: Unripe cervix prevents entering the endometrial cavity during intrauterine procedures. Mechanical dilatation of cervical canal might cause undesirable complications. OBJECTIVE: To investigate the substitute of mechanical intervention with chemical treatment by administering hyoscine to patients. MATERIALS AND METHODS: Sixty non-pregnant women, 20-70 years of age, with a closed cervix who were scheduled for an intrauterine procedure, were randomly divided into two groups...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27980224/influence-of-aging-on-the-activity-of-mice-sca-1-cd31-cardiac-stem-cells
#20
Qiong Wu, Jinxi Zhan, Shiming Pu, Liu Qin, Yun Li, Zuping Zhou
Therapeutic application of cardiac resident stem/progenitor cells (CSC/CPCs) is limited due to decline of their regenerative potential with donor age. A variety of studies have shown that the cardiac aging was the problem of the stem cells, but little is known about the impact of age on the subgroups CSC/CPCs, the relationship between subgroups CSC/CPCs ageing and age-related dysfunction. Here, we studied Sca-1+CD31- subgroups of CSCs from younger(2~3months) and older(22~24months) age mice, biological differentiation was realized using specific mediums for 14 days to induce cardiomyocyte, smooth muscle cells or endothelial cells and immunostain analysis of differentiated cell resulting were done...
December 14, 2016: Oncotarget
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