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Vitamin B6

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https://www.readbyqxmd.com/read/28643618/heat-stabilised-rice-bran-consumption-by-colorectal-cancer-survivors-modulates-stool-metabolite-profiles-and-metabolic-networks-a-randomised-controlled-trial
#1
Dustin G Brown, Erica C Borresen, Regina J Brown, Elizabeth P Ryan
Rice bran (RB) consumption has been shown to reduce colorectal cancer (CRC) growth in mice and modify the human stool microbiome. Changes in host and microbial metabolism induced by RB consumption was hypothesised to modulate the stool metabolite profile in favour of promoting gut health and inhibiting CRC growth. The objective was to integrate gut microbial metabolite profiles and identify metabolic pathway networks for CRC chemoprevention using non-targeted metabolomics. In all, nineteen CRC survivors participated in a parallel randomised controlled dietary intervention trial that included daily consumption of study-provided foods with heat-stabilised RB (30 g/d) or no additional ingredient (control)...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28631509/comparison-of-quince-with-vitamin-b6-for-treatment-of-nausea-and-vomiting-in-pregnancy-a-randomised-clinical-trial
#2
Effat Jafari-Dehkordi, Fataneh Hashem-Dabaghian, Fatemeh Aliasl, Jaleh Aliasl, Maryam Taghavi-Shirazi, Omid Sadeghpour, Farnaz Sohrabvand, Bagher Minaei, Roshanak Ghods
This trial was performed to compare quince (Cydonia oblonga) fruit with vitamin B6 on 76 pregnant women with a gestational age of 6-14 weeks and mild-to-moderate nausea and vomiting (NVP) (40 in the quince and 36 in the B6 group). The 'Pregnancy-Unique Quantification of Emesis' (PUQE-24) scale was used to examine the severity of NVP. The quince syrup (1 tablespoon/TDS) or vitamin B6 tablets (20 mg/TDS) were used as intervention for 1 week. The mean (±SD) age was 27.5 (±5.2) years. The score of the PUQE was decreased from 9...
June 20, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28629250/a-comparison-between-the-effects-of-ginger-pyridoxine-vitamin-b6-and-placebo-for-the-treatment-of-the-first-trimester-nausea-and-vomiting-of-pregnancy-nvp
#3
Fatemeh Sharifzadeh, Maryam Kashanian, Jalil Kouhpayehzadeh, Fatemeh Rezaian, Narges Sheikhansari, Nooshin Eshraghi
INTRODUCTION: Nausea and vomiting of pregnancy (NVP) are one of the most common complains of the early pregnancy period and are bothersome for pregnant women. Some prefer to use herbal medicine instead of chemical agents. OBJECTIVE: The purpose of the present study was to compare the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of NVP. METHOD: The study was performed as a triple blind clinical trial on pregnant women suffering mild to moderate NVP between 6-16 weeks of pregnancy...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28627191/-associations-between-insulin-resistance-and-three-b-vitamins-in-european-adolescents-the-helena-study
#4
Iris Iglesia, Marcela González-Gross, Inge Huybrechts, Pilar De Miguel-Etayo, Denes Molnar, Yannis Manios, Kurt Widhalm, Frédéric Gottrand, Anthony Kafatos, Asensión Marcos, Alejandro De la O Puerta, Catherine Leclercq, Stefaan De Henauw, Peter Stehle, Mathilde Kersting, Theodora Mouratidou, Luis Alberto Moreno
OBJECTIVE: To assess whether adolescents with high body mass index (BMI), or fat mass index (FMI), in combination with insulin resistance (assessed with the Homeostatic Model Assessment [HOMA] index), had also lower blood vitamin B6, folate and vitamin B12 concentrations. METHODS AND MATERIALS: Six hundred and fifteen adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, with data on B-vitamins (both intakes and status), and BMI, FMI, HOMA, were selected...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28620818/effects-of-atorvastatin-and-simvastatin-on-oxidative-stress-in-diet-induced-hyperhomocysteinemia-in-wistar-albino-rats-a-comparative-study
#5
T Nikolic, V Zivkovic, I Srejovic, I Stojic, N Jeremic, J Jeremic, K Radonjic, S Stankovic, R Obrenovic, D Djuric, V Jakovljevic
Considering the well-known antioxidant properties of statins, it seems important to assess their impact on major markers of oxidative stress (superoxide anion radical, nitric oxide, and index of lipid peroxidation) to compare the antioxidative potentials of atorvastatin and simvastatin during the different degrees of hyperhomocysteinemia (HHcy) in rats. This study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 ± 15 g body mass) in which HHcy was achieved by dietary manipulation...
June 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28620200/urinary-metabolomics-reveals-the-therapeutic-effect-of-huangqi-injections-in-cisplatin-induced-nephrotoxic-rats
#6
Chang-Yin Li, Hui-Ting Song, Xiao-Xiao Wang, Yao-Yao Wan, Xuan-Sheng Ding, Shi-Jia Liu, Guo-Liang Dai, Yue-Heng Liu, Wen-Zheng Ju
The side effects of cisplatin (CDDP), notably nephrotoxicity, greatly limited its use in clinical chemotherapy. HuangQi Injections (HI), a commonly used preparation of the well-known Chinese herbal medicine Astragali radix, appeared to be promising treatment for nephrotoxicity without compromising the anti-tumor activity of CDDP. In this study, the urinary metabolomics approach using liquid chromatography time of flight mass spectrometry (LC-TOF/MS) was developed to assess the toxicity-attenuation effects and corresponding mechanisms of HI on CDDP-exposed rats...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614956/interventions-for-treating-hyperemesis-gravidarum-a-cochrane-systematic-review-and-meta-analysis
#7
Rupsa C Boelig, Samantha J Barton, Gabriele Saccone, Anthony J Kelly, Steven J Edwards, Vincenzo Berghella
INTRODUCTION: While nausea and vomiting in early pregnancy are very common, affecting approximately 80% of pregnancies, hyperemesis gravidarum is a severe form affecting 0.3-1.0% of pregnancies. Although hyperemesis gravidarum is rarely a source of mortality, it is a significant source of morbidity. It is one of the most common indications for hospitalization in pregnancy. Beyond the maternal and fetal consequences of malnutrition, the severity of hyperemesis symptoms causes a major psychosocial burden leading to depression, anxiety, and even pregnancy termination...
June 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28606218/dietary-supplement-use-in-the-older-population-of-iceland-and-association-with-mortality
#8
Birta Ólafsdóttir, Ingibjörg Gunnarsdóttir, Hjálmfríður Nikulásdóttir, Guðný Eiríksdóttir, Tamara B Harris, Lenore J Launer, Vilmundur Guðnason, Thórhallur I Halldórsson, Kristjana Einarsdóttir
Dietary supplements are often used by the elderly to improve their nutritional status. However, intake above the recommended dietary levels may be detrimental, and uncertainty exists on the potential health benefits of supplementation in this population. The aim of this study was to describe supplement use among Icelandic older adults and to assess its association with total mortality and CVD-related mortality. This study used data from the Age Gene/Environment Susceptibility-Reykjavik study, which recruited 5764 participants aged 66-98 years in 2002-2006...
June 13, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28604131/micronutrient-intake-and-the-contribution-of-dietary-supplements-in-hispanic-infants
#9
Kiara Amaro-Rivera, Andrea López-Cepero, Beatriz Diaz, Jae Eun Lee, Cristina Palacios
To calculate micronutrient adequacy among infants and toddlers and to determine the contribution of dietary supplements to this adequacy, micronutrient intake was assessed using two nonconsecutive 24-hour recalls in a sample of 296 infants aged 0-24 months. Micronutrient intake was calculated from foods and beverages and from supplements and compared between nonusers and users of supplements. Percentages of children below the Dietary Reference Intake (DRI) and above the tolerable upper limit intake (UL) were also compared between groups...
June 12, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28602467/intake-of-b-vitamins-and-impairment-in-physical-function-in-older-adults
#10
Ellen A Struijk, Alberto Lana, Pilar Guallar-Castillón, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
BACKGROUND: The effect of vitamin B intake on physical function is not well known. OBJECTIVE: To examine the prospective association of the intake of vitamins B6, B12 and folate with physical function impairment in older adults. METHODS: We performed a prospective cohort study with 1630 participants from the Seniors-ENRICA study, a cohort of community-dwelling adults aged ≥60 years who were free of physical function impairment at baseline...
May 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28598562/genetic-polymorphisms-and-folate-status
#11
REVIEW
Mami Hiraoka, Yasuo Kagawa
Moderate hyperhomocysteinemia-induced low folate status is an independent risk factor for cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one-carbon metabolism pathway and is necessary in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. In the folate cycle and homocysteine metabolism, folate, vitamin B12, vitamin B6, and vitamin B2 are important cofactors. Many enzymes are involved in folate transport and uptake, the folate pathway, and homocysteine (Hcy) metabolism, and various polymorphisms have been documented in these enzymes...
June 9, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28587059/selected-risk-nutritional-factors-for-chemotherapy-induced-polyneuropathy
#12
Jiri Grim, Alena Ticha, Radomir Hyspler, Martin Valis, Zdenek Zadak
The present study seeks to identify the nutritional risk factors involved in the development of neuropathies induced by chemotherapeutic treatments. Unlike the gastrointestinal or hematological adverse effects of chemotherapy there is no protective treatment strategy for polyneuropathy. The aim of this study was to find possible deficiencies in nutritional factors, which can be used for supplementation in the future for prevention of chemotherapy-induced neuropathy development. We analyzed 70 patients undergoing paclitaxel chemotherapy and evaluated the risk factors involved in chemotherapy-induced peripheral neuropathy (CIPN)...
May 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28580391/case-series-odontohypophosphatasia-or-missed-diagnosis-of-childhood-adult-onset-hypophosphatasia-call-for-a-long-term-follow-up-of-premature-loss-of-primary-teeth
#13
Mari Mori, Stephanie L DeArmey, Thomas J Weber, Priya S Kishnani
INTRODUCTION: Hypophosphatasia, a metabolic bone disease caused by a tissue-nonspecific alkaline phosphatase deficiency, leads to undermineralization of bone and/or teeth, impaired vitamin B6 metabolism, and a spectrum of disease presentation. At the mild end of the spectrum, it presents as pathologic fractures in later adulthood. Patients with isolated dental manifestations, typically presenting as premature loss of primary teeth, are classified as having odontohypophosphatasia (odontoHPP)...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28574605/b-vitamins-and-hip-fracture-secondary-analyses-and-extended-follow-up-of-two-large-randomized-controlled-trials
#14
M Garcia Lopez, K H Bønaa, M Ebbing, E F Eriksen, C G Gjesdal, O Nygård, G S Tell, P M Ueland, H E Meyer
Elevated plasma homocysteine levels are associated with increased risk of fractures in observational studies. However, it is unsettled if homocysteine-lowering treatment affects fracture risk. The aim of this study was to investigate the effect of an intervention with B-vitamins on the risk of hip fracture in a secondary analysis of combined data from two large randomized controlled trials originally designed to study cardiovascular diseases. Both trials had identical design, intervention and primary objective...
June 2, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28569561/vitamin-b6-intake-and-the-risk-of-colorectal-cancer-a-meta-analysis-of-prospective-cohort-studies
#15
Kai Jia, Rong Wang, Jingfeng Tian
OBJECTIVES: We performed this meta-analysis to estimate the association between vitamin B6 intake and colorectal cancer risk. METHODS: Prospective cohort studies on vitamin B6 intake and colorectal cancer risk were identified by searching databases from the period of 1960 to 2016. Results from individual studies were synthetically combined using Stata 13.0 software. RESULTS: A total of 10 prospective cohort studies including 13 data sets were included in our meta-analysis, containing 7,817 cases and 784,550 subjects...
June 1, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28568053/low-vitamin-b12-increases-risk-of-gastric-cancer-a-prospective-study-of-one-carbon-metabolism-nutrients-and-risk-of-upper-gastrointestinal-tract-cancer
#16
Eugenia H Miranti, Rachael Stolzenberg-Solomon, Stephanie J Weinstein, Jacob Selhub, Satu Männistö, Philip R Taylor, Neal D Freedman, Demetrius Albanes, Christian C Abnet, Gwen Murphy
Previous studies have found associations between one-carbon metabolism nutrients and risk of several cancers, but little is known regarding upper gastrointestinal tract (UGI) cancer. We analyzed prediagnostic serum concentrations of several one-carbon metabolism nutrients (vitamin B12, folate, vitamin B6, riboflavin and homocysteine) in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers, which was undertaken in Finland between 1985 and 1988...
May 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28556429/acute-nutritional-axonal-neuropathy
#17
Johanna Hamel, Eric L Logigian
INTRODUCTION: This study describes clinical, laboratory, and electrodiagnostic features of a severe acute axonal polyneuropathy common to patients with acute nutritional deficiency in the setting of alcoholism, bariatric surgery (BS), or anorexia. METHODS: Retrospective analysis of clinical, electrodiagnostic, and laboratory data of patients with acute axonal neuropathy. RESULTS: Thirteen patients were identified with a severe, painful, sensory or sensorimotor axonal polyneuropathy that developed over 2-12 weeks with sensory ataxia, areflexia, variable muscle weakness, poor nutritional status, and weight loss, often with prolonged vomiting and normal cerebrospinal fluid protein...
May 26, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28552877/gluten-free-flours-from-different-raw-materials-as-the-source-of-vitamin-b1-b2-b3-and-b6
#18
Iga Rybicka, Anna Gliszczynska-Swiglo
Gluten-free (GF) products are those with a natural absence or acceptable level (<20 mg/kg) of gluten. They should be a part of a diet for people with gluten-related disorders, like celiac disease. Recently the popularity of a gluten-free diet (GFD) has risen extremely, because a lot of healthy individuals exclude gluten from their menus. According to the literature data on nutritional deficiencies in the GFD, this trend seems to be risky. This paper describes the nutritional value of 14 flours from different GF raw materials from the aspect of B-group vitamin content (B1, B2, B3, B6)...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28550206/the-pseudoenzyme-pdx1-2-sustains-vitamin-b6-biosynthesis-as-a-function-of-heat-stress
#19
Elisa Dell'Aglio, Svetlana Boycheva, Teresa B Fitzpatrick
Plants sense temperature changes and respond by altering growth and metabolic activity to acclimate to the altered environmental conditions. The B vitamins give rise to vital coenzymes that are indispensable for growth and development but their inherent reactive nature renders them prone to destruction especially under stress conditions. Therefore, plant survival strategies would be expected to include mechanisms to sustain B vitamin supply under demanding circumstances. Here, using the example of vitamin B6, we investigate the regulation of biosynthesis across eudicot and monocot species under heat stress...
May 26, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28549143/bile-acids-and-tryptophan-metabolism-are-novel-pathways-involved-in-metabolic-abnormalities-in-bpa-exposed-pregnant-mice-and-male-offspring
#20
Martha Susiarjo, Frances Xin, Martha Stefaniak, Clementina Mesaros, Rebecca A Simmons, Marisa S Bartolomei
Increasing evidence has demonstrated that exposure to endocrine disrupting chemicals (EDCs) impacts maternal and fetal health, but the underlying mechanisms are still unclear. We have previously shown that dietary exposure to 10 µg/kg bw/day and 10 mg/kg bw/day bisphenol A (BPA) during pregnancy induced metabolic abnormalities in F1 male offspring and gestational glucose intolerance in F0 pregnant mice. The aim of this study is to elucidate the underlying etiologies of BPA exposure-induced metabolic disease by analyzing male fetal liver metabolome...
May 25, 2017: Endocrinology
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