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Vitamin B6

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https://www.readbyqxmd.com/read/29764693/prospective-cohort-studies-of-dietary-vitamin-b6-intake-and-risk-of-cause-specific-mortality
#1
Long-Gang Zhao, Xiao-Ou Shu, Hong-Lan Li, Jing Gao, Li-Hua Han, Jing Wang, Jie Fang, Yu-Tang Gao, Wei Zheng, Yong-Bing Xiang
BACKGROUND & AIMS: Vitamin B6 has been postulated to play an important role in determining chronic diseases. However, few studies have evaluated associations between dietary vitamin B6 and cause-specific mortality comprehensively. METHODS: We investigated the associations between vitamin B6 from diet and risk of all-cause, and cause-specific mortality in 134,480 participants from the Shanghai Men's Health Study (2002-2014) and Shanghai Women's Health Study (1997-2014)...
May 4, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29757052/multimodal-characterization-of-a-novel-mutation-causing-vitamin-b6-responsive-gyrate-atrophy
#2
Xuan Cui, Ruben Jauregui, Karen Sophia Park, Stephen H Tsang
PURPOSE: Gyrate atrophy (GA) is a rare chorioretinal degeneration that results in the deterioration of night and peripheral vision, eventually leading to blindness. The disorder is caused by mutations in the gene encoding ornithine aminotransferase (OAT), causing increased levels of plasma ornithine. Treatment revolves around lowering plasma ornithine levels, with vitamin B6 supplementation being the preferred treatment. Nevertheless, most patients do not respond to this therapy. Here, we report a rare case of vitamin B6-responsive GA caused by a novel mutation in OAT and characterize the presentation with multimodal imaging...
May 14, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29756721/-pseudotumor-cerebri-associated-with-hypovitaminosis-a-b6-and-d-about-two-cases
#3
Ana M Silva, José Méndez, Marisol Toma, Alejandra González, Federico Bois
Idiopathic endocranial hypertension is infrequently associated with hypovitaminosis A and D. The case of an 8-year-old female with 24-hour blurred vision and bilateral papilledema is presented. Nuclear magnetic resonance was normal. Opening pressure of cerebrospinal fluid: 260 mmH2O. She presented vitamin A and D deficiency and started replacement therapy. The second case corresponds to a 12-year-old male with fever and odynophagia of 3 days. History of glomerulonephritis and overweight. He had bipalpebral edema and papilledema...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29754386/nutritional-deficiencies-in-chinese-patients-undergoing-gastric-bypass-and-sleeve-gastrectomy-prevalence-and-predictors
#4
Bingsheng Guan, Jingge Yang, Yanya Chen, Wah Yang, Cunchuan Wang
BACKGROUND: Nutritional deficiencies have been reported in bariatric surgery patients with inconsistent results. However, scarce data exist for Chinese patients. We aimed to assess nutritional deficiencies in Chinese patients undergoing Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), and to identify predictors of postoperative nutritional status. METHODS: A retrospective review of a prospectively collected database was conducted in the patients undergoing RYGB and SG in our hospital between June 2013 and January 2017...
May 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29752770/one-carbon-cycle-support-rescues-sperm-damages-in-experimentally-induced-varicocele-in-rats
#5
Parisa Mohammadi, Hassan Hassani Bafrani, Marziyeh Tavalaee, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani
OBJECTIVES: To demonstrate that micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage following surgical varicocele in rats and that this effect is achieved without suffering a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS: Surgical varicocele was induced in adult male Wistar rats and resulted in significant damage to testis and sperm cells measured 2 and 4 months post-surgery...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29738862/vitamin-b6-biosynthetic-genes-expression-and-antioxidant-enzyme-properties-in-tomato-against-erwinia-carotovora-subsp-carotovora
#6
Murugesan Chandrasekaran, Se Chul Chun
Vitamin B6 (VitB6) is an essential cofactor for >140 biochemical reactions. Also, VitB6 is a potent antioxidant and helps plants cope with both biotic and abiotic stress conditions. However, the role of VitB6 in plant disease resistance has yet to be confirmed using molecular biology approaches. Here, we analyzed the expression patterns of VitB6 biosynthetic genes, including the de novo (PDX1 [PDX1.2 and 1.3] and PDX2) and the salvage (SOS4) pathways during the response to Erwinia carotovora subsp. carotovora...
May 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29737502/vitamin-b-6-in-health-supplements-and-neuropathy-case-series-assessment-of-spontaneously-reported-cases
#7
Florence van Hunsel, Sonja van de Koppel, Eugène van Puijenbroek, Agnes Kant
INTRODUCTION: In the literature, vitamin B6 has been linked to the development of polyneuropathy. Most often, these complaints were seen when taking high doses of vitamin B6 for a long time. Evidence as to whether a lower dosage range of vitamin B6 (< 50 mg/day) can also induce neuropathy is scarce. OBJECTIVE: We aim to comprehensively describe the cases of neuropathy associated with vitamin B6 received by the Netherlands Pharmacovigilance Centre Lareb and to assess the case series concerning the use of vitamin B6 and neuropathic complaints...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29737293/effect-of-sedative-drugs-with-vitamin-b6-combined-with-other-b-vitamins-in-the-anti-stress-of-captive-amur-tiger
#8
Qiao Zhenglei, Ma Jianzhang
In order to reduce the stress response of animals in animal transportation, it is often used to feed the animals with sedative drugs combined with compound vitamin B. In this article, we will randomly divide 16 amur tiger into the control group and the experimental group. The drug intervention is carried out in the experimental group. The sedative is mainly dexmedetomidine, combined with compound vitamin B, while control group did not feed the drug. The urine of two groups of individuals was collected before and after transportation and the cortisol content in urine was determined by radioimmunoassay as an indication of stress...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29736096/potential-anti-inflammatory-treatment-of-ischemic-heart-disease
#9
Enisa Hodzic
Introduction: Ischemic heart disease (IHD) is clinical manifestation of chronic inflammatory progressive pathological process of atherosclerosis in coronary arteries. IHD is the leading cause of morbidity and mortality in the world. The question is whether it is possible to improve and direct the therapeutic treatment of IHD patients in the treatment of the inflammatory process in the atherosclerotic leasions. Material and Methods: A prospective, comparative, analytica,clinically applicable, open-type study was performed...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29735460/effect-of-sedative-drugs-with-vitamin-b6-combined-with-other-b-vitamins-in-the-anti-stress-of-captive-amur-tiger
#10
Qiao Zhenglei, Ma Jianzhang
In order to reduce the stress response of animals in animal transportation, it is often used to feed the animals with sedative drugs combined with compound vitamin B. In this article, we will randomly divide 16 amur tiger into the control group and the experimental group. The drug intervention is carried out in the experimental group. The sedative is mainly dexmedetomidine, combined with compound vitamin B, while control group did not feed the drug. The urine of two groups of individuals was collected before and after transportation and the cortisol content in urine was determined by radioimmunoassay as an indication of stress...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29734388/a-prospective-evaluation-of-serum-kynurenine-metabolites-and-risk-of-pancreatic-cancer
#11
Joyce Y Huang, Lesley M Butler, Øivind Midttun, Arve Ulvik, Renwei Wang, Aizhen Jin, Yu-Tang Gao, Per M Ueland, Woon-Puay Koh, Jian-Min Yuan
BACKGROUND: Serum pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, is associated with reduced risk of pancreatic cancer. Data on functional measures of vitamin B6 status and risk of pancreatic cancer is lacking. METHODS: A nested case-control study involving 187 incident cases of pancreatic cancer and 362 individually matched controls were conducted within two prospective cohorts to evaluate the associations between kynurenine metabolites in pre-diagnostic serum samples and risk of pancreatic cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29731400/treatment-of-infantile-spasms-by-pediatric-neurologists-in-japan
#12
Shin-Ichiro Hamano, Toshisaburo Nagai, Ryuki Matsuura, Yuko Hirata, Satoru Ikemoto, Atsuko Oba, Erika Hiwatari
OBJECTIVE: To clarify changes in clinical practice for infantile spasms, including West syndrome, in Japan over the past two decades. METHODS: We investigated common treatment strategies for infantile spasms among 157 pediatric neurologists from a designated training facility for pediatric neurology and/or a designated training facility for epilepsy in Japan. A questionnaire was used to investigate use of adrenocorticotropic hormone (ACTH) therapy including daily dose, treatment duration, and tapering off period, and preferred first to fifth-line treatment choices...
May 3, 2018: Brain & Development
https://www.readbyqxmd.com/read/29724193/chronophin-regulates-active-vitamin-b6-levels-and-transcriptomic-features-of-glioblastoma-cell-lines-cultured-under-non-adherent-serum-free-conditions
#13
Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Floßbach, Camelia Monoranu, Markus J Riemenschneider
BACKGROUND: The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin binding protein cofilin, and pyridoxal 5'-phosphate, the active form of vitamin B6. Phosphoregulation of cofilin, among other functions, plays an important role in cell migration, whereas active vitamin B6 is a cofactor for more than one hundred enzymatic reactions. The role of CIN has yet only been examined in glioblastoma cell line models derived under serum culture conditions...
May 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29721678/what-is-the-relationship-between-physical-fitness-level-and-macro-and-micronutrient-intake-in-spanish-older-adults
#14
R Aparicio-Ugarriza, R Luzardo-Socorro, G Palacios, M M Bibiloni, E Argelich, J A Tur, Marcela González-Gross
PURPOSE: The aim of this study was to assess the association between physical fitness (PF) and energy and nutrient intake in Spanish older adults. METHODS: Three hundred and twenty-four participants (59.9% females, aged over 55 years) performed a battery of four validated PF tests and participants were divided into three: low, medium, and high PF. Dietary intake was assessed by two non-consecutive 24 h dietary recalls. Energy and nutrient intake was calculated using the ALIMENTA software...
May 2, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29713147/effects-of-oral-amino-acid-supplementation-on-multidimensional-prognostic-index-in-hospitalized-older-patients-a-multicenter-randomized-double-blind-placebo-controlled-pilot-study
#15
Stefano Volpato, Romina Custureri, Matteo Puntoni, Lara Bianchi, Julia Daragjati, Sara Garaboldi, Matteo Simonato, Antonio Greco, Emanuele Rizzo, Pierluigi Dal Santo, Antonio Mangiacotti, Ekaterini Zigoura, Giacomo Siri, Alberto Pilotto
Background: It is not known whether amino acid supplementations may influence health status in hospitalized older acutely ill patients. Aim: The aim of this study was to determine whether nutritional supplementation with amino acids (Aminoglutam® ) is associated with multidimensional improvement assessed with the Multidimensional Prognostic Index (MPI). Methods: In this randomized, double-blind, placebo-controlled pilot clinical trial, 126 patients aged ≥65 years were enrolled from 6 Italian geriatric wards...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29712719/dietary-intake-and-age-at-natural-menopause-results-from-the-uk-women-s-cohort-study
#16
Yashvee Dunneram, Darren Charles Greenwood, Victoria J Burley, Janet E Cade
BACKGROUND: Age at natural menopause is a matter of concern for women of reproductive age as both an early or late menopause may have implications for health outcomes. METHODS: Study participants were women aged 40-65 years who had experienced a natural menopause from the UK Women's Cohort Study between baseline and first follow-up. Natural menopause was defined as the permanent cessation of menstrual periods for at least 12 consecutive months. A food frequency questionnaire was used to estimate diet at baseline...
April 30, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29710037/organ-co-relationship-in-tryptophan-metabolism-and-factors-that-govern-the-biosynthesis-of-nicotinamide-from-tryptophan
#17
Katsumi Shibata
The pathway of tryptophan (Trp)-nicotinamide is very important nutritionally because a vitamin nicotinamide is biosynthesized from an amino acid Trp. Until we started studying the factors that affect the Trp-nicotinamide conversion rate, little data existed. Data obtained from TDO (Trp 2,3-dioxygenase)-KO (knock-out) mice have revealed that mice can biosynthesize a necessary amount of nicotinamide from Trp by indoleamine 2,3-dioxygenase (IDO) even when TDO is lacking. It has also been shown that 3-hydroxyanthranilic acid is a key intermediate...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29710029/gender-difference-and-dietary-supplemental-vitamin-b-6-impact-on-colon-luminal-environment
#18
Dwi Eva Nirmagustina, Yongshou Yang, Thanutchaporn Kumrungsee, Noriyuki Yanaka, Norihisa Kato
Colon diseases can be affected by several factors such as gender difference and dietary supplemental vitamin B6 (B6 ). The nutritional status of B6 is affected by gender difference, leading us to hypothesize that gender difference affects colon luminal environment, which is dependent on B6 status. To investigate this hypothesis, we fed male and female rats a diet containing 1 mg, 7 mg, or 35 mg pyridoxine HCl/kg diet for 6 wk. We found significantly higher fecal mucin levels in female rats compared to those in male rats...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29701137/impact-of-food-pantry-donations-on-diet-of-a-low-income-population
#19
Tamara Y Mousa, Jean H Freeland-Graves
OBJECTIVE: This cross-sectional study assessed the effect of food donations on total nutrient intake of clients of a food pantry in Central Texas. METHODS: Nutrient intakes of total, base and food donation diets were estimated for 112 food pantry recipients using specific questionnaires; and then compared to the dietary reference intakes (DRI) and 2015-2020 US Dietary Guidelines. RESULTS: Food donations accounted for more than half of the client's daily intake of energy, carbohydrates, vitamin B6 , phosphorus, copper and selenium...
April 27, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29690963/carbamazepine-verses-valproic-acid-as-monotherapy-in-epileptic-patients
#20
Shakirullah Shakir, Niaz Ali, Haleema Nazish
OBJECTIVE: To evaluate the effectiveness of carbamazepine and valproic acid as monotherapy in epileptic patients of Pakhtun population. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: The outpatient Neurology Department, Lady Reading Hospital, Peshawar, from August 2014 to April 2016. METHODOLOGY: Epileptic patients placed on carbamazepine and volproic acid were inducted. Carbamazepine and valproic acid plasma levels were determined using reverse phase high performance liquid chromatography...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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